                         SEQUENCE LISTING

<110>  Council of Scientific and Industrial Research
 
<120>  Novel DNA repair protein and biomarker for  melanoma

<130>  0186NF2018

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  3790
<212>  DNA
<213>  Homo sapiens

<400>  1
agggagggga gggatggggg gaaagcaagc tggaggacag gtgagacagc aggacaggtg       60

aggcgggccc tgaggggggg gcgggtggga gccaggtgaa tgtacggctc ttggcggccg      120

agggggggcg ggcggcagga ggaggcagag ggcggcggag gaggagcccc ccagcagcga      180

gcggcgagca actgaccgcg gccttctgac caggaccgga gcagggcccc aagcccccgg      240

gcctggtggg ggacgcgctt cttcccacac tgtgagcctc agcagctcca gccagcggac      300

ccgacggctg agaggagaag atggggagcc ccgaggatga cctgattggg attccattcc      360

cggaccacag cagtgagctc ctgagctgcc tcaatgagca gcgccagctg ggccacctat      420

gtgacctcac catccggacg cagggccttg aataccgcac ccacagggct gtgctagctg      480

cctgtagcca ctacttcaag aagcttttca ctgagggcgg tggcggagct gtcatggggg      540

ccgggggtag cgggacggcc actgggggag caggggccgg tgtgtgtgag ctggactttg      600

tagggccaga ggcactaggc gccctccttg aatttgccta tacagccaca ctgaccacca      660

gcagcgccaa catgccagct gtgctccagg ctgcccgcct gctggagatc ccgtgtgtca      720

tcgctgcttg catggagatt ctgcagggca gtgggctaga agctcccagc ccggacgagg      780

atgactgtga gcgagcccgc cagtatctgg aggcctttgc cacagccacg gcctctggag      840

ttcccaatgg tgaagacagt cctccacagg tgcccctccc accacctccg ccaccgccac      900

ctcggcctgt tgcccgccgc agccgcaagc cccggaaagc tttcctgcaa accaaggggg      960

ccagagcaaa ccacctagtc cctgaggtgc ccacagtgcc cgcccatccc ttgacctatg     1020

aggaggagga ggtggcgggc agagtgggca gcagtggggg cagtgggccg ggggacagct     1080

acagccctcc cacaggaact gcctcccctc ctgagggtcc ccagagctac gaaccctatg     1140

agggtgagga agaagaagag gagctggtat atcccccagc ctatgggctg gcgcagggtg     1200

gcgggccccc gctgtcccca gaggagctgg gctcagatga ggatgccatc gatcctgacc     1260

tgatggccta cctaagctcc ctgcaccagg acaacctggc accaggcctg gacagccaag     1320

acaagctggt gcgcaaacgc cgctcccaga tgcctcagga gtgccctgtc tgccacaaga     1380

tcatccatgg ggcaggcaaa ctgcctcgcc acatgaggac ccacacaggc gagaagccct     1440

ttgcctgcga ggtctgcggt gttcgattca ccaggaacga caagctgaag atccacatgc     1500

ggaagcacac gggagagcgc ccctactcat gcccgcactg cccagcccgc ttcctgcaca     1560

gctacgacct caagaaccac atgcacctgc acacagggga ccggccctat gagtgccacc     1620

tgtgccacaa ggctttcgcc aaggaggacc acctgcagcg ccacctcaaa ggccagaact     1680

gcctggaggt gcgcacccga cggcgccgca aggacgatgc accaccccac tacccaccac     1740

cctctaccgc tgctgcatcc cccgctggcc tcgacctctc caatggccac ctggacacct     1800

tccgcctctc tctagctcga ttctgggagc agtcagcccc cactgggccc ccggtctcta     1860

ccccagggcc ccctgatgac gatgaggagg aaggggcacc caccacaccc caggctgaag     1920

gtgccatgga gtcctcttaa agagggacga gggccagact gaagcagcac aaggccgggg     1980

acacccatgc caagcagtgg gagcacgcag gacagacaca gcaggggtct ggggcacgga     2040

gccttgctgg catcagcatc agcccttcct cccagagccc tcattccaat tccaagctaa     2100

gaaggtattg gggcagaggc tccccaaatt ggggtgatcc cccaaggagt gatacatata     2160

ttgtgtatat atttacagct gtattgtaaa agtggggtcc ctgtccccag ctgctcctgg     2220

ggagtagaag caataatgta tttctaattt gtgggtccca cttcggctat gcgggtttct     2280

agggggtggg ggcttgggac caaagccttg ccccgcccct atgccccttg ggggttttgg     2340

ctgtgtaagg gggtgaagga ctgcccctcc ctttcgagac ccctccttcc tggtttctgt     2400

tcctttttcc tggcagtgaa ttatgcaaag ggggccggca aaggaagggt aggtggggga     2460

aagccaggtg gaagcttgaa agactggggg actgggcctg taaggaagga gccatcccag     2520

tccccctccg ccctgctccc ggcgctgagt catggggtcg tggagaaggg ggcggggtgg     2580

cctgattggc tcgcctgccc ctgggggcag tagaggggcc ccgcccagct aggggagccg     2640

ctccgttcca ctcccctccc tagccctccc tccccacggc cctgggcagg gaatgtcttg     2700

ttcccgccgc tccctccccg gggccagagg gcagggcggg ccgggcggcg tcctaccctc     2760

ttctcctcct ccccatctcc tccccgccca ggtgcgagcc ggagccgccg ccaccgctgc     2820

cgcccctgac tcacgccgcc cccgggctgg cgcagcgaag ggtgtgggac agggtaaggg     2880

gttggaagag ccttgtggag agcgggcgag ccggcgccat ctggcggcca tgctctgagt     2940

gggcgagcgc cccccgcggc cactggagcg agctgtcttc acgctcctca tccaccccag     3000

ctggtgagcg gcgccccctt gccaaggcag tgggcacaga acttctcgct tggccgcagg     3060

ggaaggggct gcggacctgt gggaaagtga tccccttccc agatccttgc cagccgggct     3120

tcctgtcagg caggggagaa taatccccac tctgctctta ggattgaatc cacccccatt     3180

ctgtacatag cctcttctgt tggtcttgtt gaaatctagt ttcagatttt taactaccca     3240

attctgctgg gggtggggga caccccccct tcctcgctgg gtgctggacc ccttttgcag     3300

cctgggctct gccttgcact atttcccctt cctggcctga cggctcctcc ccctccttaa     3360

aaggggcagg ttcaggggcc cggtgctctt cctcccttcc atgcaccccc atgcccattt     3420

gcacagctgc ccaggtaccc ctaacagtgg ggaggggtca cagggagggg gtagcgggac     3480

cagtccctgt tatctattta aaaagtgatg atgtaatata ttggggtggc ggggagatcg     3540

ggttgtcctg ggcctcatct tagcatttca ggtgatgggg ggagcccagg gctggggaga     3600

cctggggccc agccccagaa agtggggaca atgtggcctc ccttctccct actttcggct     3660

ttcccagtca gtgccttagg gggagaggca ctccccccct cctattccct tccccccacc     3720

ccaactcccc cacctcgggt gtaagcgaca ggaagaaata ataataattt aagattcaca     3780

aaaaaaaaaa                                                            3790


<210>  2
<211>  1620
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggagcc ccgaggatga cctgattggg attccattcc cggaccacag cagtgagctc       60

ctgagctgcc tcaatgagca gcgccagctg ggccacctat gtgacctcac catccggacg      120

cagggccttg aataccgcac ccacagggct gtgctagctg cctgtagcca ctacttcaag      180

aagcttttca ctgagggcgg tggcggagct gtcatggggg ccgggggtag cgggacggcc      240

actgggggag caggggccgg tgtgtgtgag ctggactttg tagggccaga ggcactaggc      300

gccctccttg aatttgccta tacagccaca ctgaccacca gcagcgccaa catgccagct      360

gtgctccagg ctgcccgcct gctggagatc ccgtgtgtca tcgctgcttg catggagatt      420

ctgcagggca gtgggctaga agctcccagc ccggacgagg atgactgtga gcgagcccgc      480

cagtatctgg aggcctttgc cacagccacg gcctctggag ttcccaatgg tgaagacagt      540

cctccacagg tgcccctccc accacctccg ccaccgccac ctcggcctgt tgcccgccgc      600

agccgcaagc cccggaaagc tttcctgcaa accaaggggg ccagagcaaa ccacctagtc      660

cctgaggtgc ccacagtgcc cgcccatccc ttgacctatg aggaggagga ggtggcgggc      720

agagtgggca gcagtggggg cagtgggccg ggggacagct acagccctcc cacaggaact      780

gcctcccctc ctgagggtcc ccagagctac gaaccctatg agggtgagga agaagaagag      840

gagctggtat atcccccagc ctatgggctg gcgcagggtg gcgggccccc gctgtcccca      900

gaggagctgg gctcagatga ggatgccatc gatcctgacc tgatggccta cctaagctcc      960

ctgcaccagg acaacctggc accaggcctg gacagccaag acaagctggt gcgcaaacgc     1020

cgctcccaga tgcctcagga gtgccctgtc tgccacaaga tcatccatgg ggcaggcaaa     1080

ctgcctcgcc acatgaggac ccacacaggc gagaagccct ttgcctgcga ggtctgcggt     1140

gttcgattca ccaggaacga caagctgaag atccacatgc ggaagcacac gggagagcgc     1200

ccctactcat gcccgcactg cccagcccgc ttcctgcaca gctacgacct caagaaccac     1260

atgcacctgc acacagggga ccggccctat gagtgccacc tgtgccacaa ggctttcgcc     1320

aaggaggacc acctgcagcg ccacctcaaa ggccagaact gcctggaggt gcgcacccga     1380

cggcgccgca aggacgatgc accaccccac tacccaccac cctctaccgc tgctgcatcc     1440

cccgctggcc tcgacctctc caatggccac ctggacacct tccgcctctc tctagctcga     1500

ttctgggagc agtcagcccc cactgggccc ccggtctcta ccccagggcc ccctgatgac     1560

gatgaggagg aaggggcacc caccacaccc caggctgaag gtgccatgga gtcctcttaa     1620


<210>  3
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ser Pro Glu Asp Asp Leu Ile Gly Ile Pro Phe Pro Asp His 
1               5                   10                  15      


Ser Ser Glu Leu Leu Ser Cys Leu Asn Glu Gln Arg Gln Leu Gly His 
            20                  25                  30          


Leu Cys Asp Leu Thr Ile Arg Thr Gln Gly Leu Glu Tyr Arg Thr His 
        35                  40                  45              


Arg Ala Val Leu Ala Ala Cys Ser His Tyr Phe Lys Lys Leu Phe Thr 
    50                  55                  60                  


Glu Gly Gly Gly Gly Ala Val Met Gly Ala Gly Gly Ser Gly Thr Ala 
65                  70                  75                  80  


Thr Gly Gly Ala Gly Ala Gly Val Cys Glu Leu Asp Phe Val Gly Pro 
                85                  90                  95      


Glu Ala Leu Gly Ala Leu Leu Glu Phe Ala Tyr Thr Ala Thr Leu Thr 
            100                 105                 110         


Thr Ser Ser Ala Asn Met Pro Ala Val Leu Gln Ala Ala Arg Leu Leu 
        115                 120                 125             


Glu Ile Pro Cys Val Ile Ala Ala Cys Met Glu Ile Leu Gln Gly Ser 
    130                 135                 140                 


Gly Leu Glu Ala Pro Ser Pro Asp Glu Asp Asp Cys Glu Arg Ala Arg 
145                 150                 155                 160 


Gln Tyr Leu Glu Ala Phe Ala Thr Ala Thr Ala Ser Gly Val Pro Asn 
                165                 170                 175     


Gly Glu Asp Ser Pro Pro Gln Val Pro Leu Pro Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Arg Pro Val Ala Arg Arg Ser Arg Lys Pro Arg Lys Ala Phe 
        195                 200                 205             


Leu Gln Thr Lys Gly Ala Arg Ala Asn His Leu Val Pro Glu Val Pro 
    210                 215                 220                 


Thr Val Pro Ala His Pro Leu Thr Tyr Glu Glu Glu Glu Val Ala Gly 
225                 230                 235                 240 


Arg Val Gly Ser Ser Gly Gly Ser Gly Pro Gly Asp Ser Tyr Ser Pro 
                245                 250                 255     


Pro Thr Gly Thr Ala Ser Pro Pro Glu Gly Pro Gln Ser Tyr Glu Pro 
            260                 265                 270         


Tyr Glu Gly Glu Glu Glu Glu Glu Glu Leu Val Tyr Pro Pro Ala Tyr 
        275                 280                 285             


Gly Leu Ala Gln Gly Gly Gly Pro Pro Leu Ser Pro Glu Glu Leu Gly 
    290                 295                 300                 


Ser Asp Glu Asp Ala Ile Asp Pro Asp Leu Met Ala Tyr Leu Ser Ser 
305                 310                 315                 320 


Leu His Gln Asp Asn Leu Ala Pro Gly Leu Asp Ser Gln Asp Lys Leu 
                325                 330                 335     


Val Arg Lys Arg Arg Ser Gln Met Pro Gln Glu Cys Pro Val Cys His 
            340                 345                 350         


Lys Ile Ile His Gly Ala Gly Lys Leu Pro Arg His Met Arg Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Phe Ala Cys Glu Val Cys Gly Val Arg Phe Thr 
    370                 375                 380                 


Arg Asn Asp Lys Leu Lys Ile His Met Arg Lys His Thr Gly Glu Arg 
385                 390                 395                 400 


Pro Tyr Ser Cys Pro His Cys Pro Ala Arg Phe Leu His Ser Tyr Asp 
                405                 410                 415     


Leu Lys Asn His Met His Leu His Thr Gly Asp Arg Pro Tyr Glu Cys 
            420                 425                 430         


His Leu Cys His Lys Ala Phe Ala Lys Glu Asp His Leu Gln Arg His 
        435                 440                 445             


Leu Lys Gly Gln Asn Cys Leu Glu Val Arg Thr Arg Arg Arg Arg Lys 
    450                 455                 460                 


Asp Asp Ala Pro Pro His Tyr Pro Pro Pro Ser Thr Ala Ala Ala Ser 
465                 470                 475                 480 


Pro Ala Gly Leu Asp Leu Ser Asn Gly His Leu Asp Thr Phe Arg Leu 
                485                 490                 495     


Ser Leu Ala Arg Phe Trp Glu Gln Ser Ala Pro Thr Gly Pro Pro Val 
            500                 505                 510         


Ser Thr Pro Gly Pro Pro Asp Asp Asp Glu Glu Glu Gly Ala Pro Thr 
        515                 520                 525             


Thr Pro Gln Ala Glu Gly Ala Met Glu Ser Ser 
    530                 535                 


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vGAF fwd primer

<400>  4
cggtgttcga ttcaccagga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vGAF rev primer

<400>  5
gcaggtgcat gtggttcttg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hist1H3A fwd primer

<400>  6
ggctcgcact aagcaaactg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hist1H3A rev primer

<400>  7
ctgccttagt ggccaactgt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Col1A1 fwd primer

<400>  8
agtggtttgg atggtgccaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Col1A1 rev primer

<400>  9
gcaccatcat ttccacgagc                                                   20


