                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HIGH AFFINITY MONOCLONAL ANTIBODIES TARGETING GLYPICAN-1 AND 
       METHODS OF USE

<130>  4239-101892-02

<150>  US 62/795,415
<151>  2019-01-22

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gcctcgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtac tcgtagctcc      300

gtaggctact ggggccaagg caccactctc acagtctcct ca                         342


<210>  2
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (HM2 VH)

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Ser Val Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  3
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cttatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagaac acatgttccg      300

tacacgttcg gaggggggac caagctggag ataaaa                                336


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (HM2 VL)

<400>  4

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Arg 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ccggggggtc tctgagactc       60

tcctgtgtag cctctggata cagctacagt attggttaca tggcctggtt ccgccaggcc      120

ccaggaaagg agcgcgcgtg ggtcgcgtct cgatatactg gtgacggtgg cgcagtcttt      180

gacgacgccg tgaagggccg attcaccacc tcccaagaga gtgccgggaa cacgttcgat      240

ttgcaaatgg acagcctgaa acctgaggac actgccatgt actattgcgc agcgaaaggg      300

cccggtttcg ggcggtggga gtactggggc cgggggaccc aggtcaccgt ctcctca         357


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (D4 mAb)

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile Gly 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp Val 
        35                  40                  45              


Ala Ser Arg Tyr Thr Gly Asp Gly Gly Ala Val Phe Asp Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe Asp 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Gly Pro Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  8
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  9
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  11
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  13
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  14
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
atgcaggtgc agctggtgga gtctggggga ggcttggtgc agcccggggg gtctctgaga       60

ctctcctgtg tagcctctgg atacagctac agtattggtt acatggcctg gttccgccag      120

gccccaggaa aggagcgcgc gtgggtcgcg tctcgatata ctggtgacgg tggcgcagtc      180

tttgacgacg ccgtgaaggg ccgattcacc acctcccaag agagtgccgg gaacacgttc      240

gatttgcaaa tggacagcct gaaacctgag gacactgcca tgtactattg cgcagcgaaa      300

gggcccggtt tcgggcggtg ggagtactgg ggccggggga cccaggtcac cgtctcctca      360

aagcttaaag caagcggcgg tcgccatcgc cagccgcgcg gctgggaaca gctgggcggt      420

ggcggtggca gccccaccgg tgccgagttc ctgggcgacg gtggcgatgt gtcctttagc      480

acccgtggta cccagaactg gacggtagag cgcctgctgc aggcacatcg tcagctggaa      540

gagcgtggct atgtattcgt tggctaccac ggcacttttc tggaagcagc tcagtccatc      600

gtgtttggtg gtgtccgtgc ccgttctcaa gacctggatg cgatttggcg tggtttctac      660

attgcaggcg atccagcgct ggcatacggt tatgcgcagg accaggaacc ggatgctcgt      720

ggtcgcattc gtaatggtgc gctgctgcgc gtatatgtgc cgcgttccag cctgccgggc      780

ttctaccgca ctagcctgac cctggccgcg ccggaggcgg cgggtgaagt ggaacgtctg      840

attggtcatc ctctgcctct gcgcctggat gccatcaccg gcccagagga ggagggcggt      900

cgtctggaaa ccattctggg ctggccgctg gctgaacgta cggtcgttat tccgagcgcg      960

attcctaccg atcctcgtaa cgttggcggc gatctggacc catcttctat tccagataag     1020

gagcaggcaa tctccgcgct gccggattat gcaagccaac cgggtaaacc acctcgtgaa     1080

gatctgaaat aa                                                         1092


<210>  15
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile 
            20                  25                  30          


Gly Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp 
        35                  40                  45              


Val Ala Ser Arg Tyr Thr Gly Asp Gly Gly Ala Val Phe Asp Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe 
65                  70                  75                  80  


Asp Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Gly Pro Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Lys Leu Lys Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Gln Pro Arg Gly Trp Glu Gln Leu Gly Gly Gly Gly Gly Ser 
    130                 135                 140                 


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
145                 150                 155                 160 


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
                165                 170                 175     


Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
            180                 185                 190         


Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg 
        195                 200                 205             


Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp 
    210                 215                 220                 


Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg 
225                 230                 235                 240 


Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser 
                245                 250                 255     


Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu 
            260                 265                 270         


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg 
        275                 280                 285             


Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr 
    290                 295                 300                 


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
305                 310                 315                 320 


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
                325                 330                 335     


Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
            340                 345                 350         


Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
        355                 360             


<210>  16
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
atggaggttc agctgcagca gtctggggct gagcttgtga ggccaggggc ctcagtcaag       60

ttgtcctgca cagcttctgg ctttaacatt aaagacgact atatgcactg ggtgaagcag      120

aggcctgaac agggcctgga gtggattgga tggattgatc ctgagaatgg tgatactgaa      180

tatgcctcga agttccaggg caaggccact ataacagcag acacatcctc caacacagcc      240

tacctgcagc tcagcagcct gacatctgag gacactgccg tctattactg tactcgtagc      300

tccgtaggct actggggcca aggcaccact ctcacagtct cctcaggcgg aggcggatca      360

ggtggtggcg gatctggagg tggcggaagc gatgttgtga tgacccaaac tccactctcc      420

ctgcctgtca gtcttggaga tcaagcctcc atctcttgca gatctagtca gagccttgta      480

cacagtaatg gaaacaccta tttacattgg tacctgcaga agccaggcca gtctccaaag      540

ctcctgatct acaaagtttc caaccgattt tctggggtcc cagacaggtt cagtggcagt      600

ggatcaggga cttatttcac actcaagatc agcagagtgg aggctgagga tctgggagtt      660

tatttctgct ctcaaagaac acatgttccg tacacgttcg gaggggggac caagctggag      720

ataaaaaagc ttaaagcaag cggcggtcgc catcgccagc cgcgcggctg ggaacagctg      780

ggcggtggcg gtggcagccc caccggtgcc gagttcctgg gcgacggtgg cgatgtgtcc      840

tttagcaccc gtggtaccca gaactggacg gtagagcgcc tgctgcaggc acatcgtcag      900

ctggaagagc gtggctatgt attcgttggc taccacggca cttttctgga agcagctcag      960

tccatcgtgt ttggtggtgt ccgtgcccgt tctcaagacc tggatgcgat ttggcgtggt     1020

ttctacattg caggcgatcc agcgctggca tacggttatg cgcaggacca ggaaccggat     1080

gctcgtggtc gcattcgtaa tggtgcgctg ctgcgcgtat atgtgccgcg ttccagcctg     1140

ccgggcttct accgcactag cctgaccctg gccgcgccgg aggcggcggg tgaagtggaa     1200

cgtctgattg gtcatcctct gcctctgcgc ctggatgcca tcaccggccc agaggaggag     1260

ggcggtcgtc tggaaaccat tctgggctgg ccgctggctg aacgtacggt cgttattccg     1320

agcgcgattc ctaccgatcc tcgtaacgtt ggcggcgatc tggacccatc ttctattcca     1380

gataaggagc aggcaatctc cgcgctgccg gattatgcaa gccaaccggg taaaccacct     1440

cgtgaagatc tgaaataa                                                   1458


<210>  17
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp 
            20                  25                  30          


Asp Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys 
    50                  55                  60                  


Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ser Ser Val Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Arg Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Lys Leu Lys Ala Ser Gly Gly Arg His Arg Gln Pro Arg Gly 
                245                 250                 255     


Trp Glu Gln Leu Gly Gly Gly Gly Gly Ser Pro Thr Gly Ala Glu Phe 
            260                 265                 270         


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
        275                 280                 285             


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
    290                 295                 300                 


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
305                 310                 315                 320 


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
                325                 330                 335     


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
            340                 345                 350         


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
        355                 360                 365             


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
    370                 375                 380                 


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
385                 390                 395                 400 


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
                405                 410                 415     


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
            420                 425                 430         


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
        435                 440                 445             


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
    450                 455                 460                 


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
465                 470                 475                 480 


Arg Glu Asp Leu Lys 
                485 


<210>  18
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
atgcaggtgc agctggtgga gtctggggga ggcttggtgc agcccggggg gtctctgaga       60

ctctcctgtg tagcctctgg atacagctac agtattggtt acatggcctg gttccgccag      120

gccccaggaa aggagcgcgc gtgggtcgcg tctcgatata ctggtgacgg tggcgcagtc      180

tttgacgacg ccgtgaaggg ccgattcacc acctcccaag agagtgccgg gaacacgttc      240

gatttgcaaa tggacagcct gaaacctgag gacactgcca tgtactattg cgcagcgaaa      300

gggcccggtt tcgggcggtg ggagtactgg ggccggggga cccaggtcac cgtctcctca      360

gcggcggcgc aggtgcagct ggtggagtct gggggaggct tggtgcagcc cggggggtct      420

ctgagactct cctgtgtagc ctctggatac agctacagta ttggttacat ggcctggttc      480

cgccaggccc caggaaagga gcgcgcgtgg gtcgcgtctc gatatactgg tgacggtggc      540

gcagtctttg acgacgccgt gaagggccga ttcaccacct cccaagagag tgccgggaac      600

acgttcgatt tgcaaatgga cagcctgaaa cctgaggaca ctgccatgta ctattgcgca      660

gcgaaagggc ccggtttcgg gcggtgggag tactggggcc gggggaccca ggtcaccgtc      720

tcctcaaagc ttaaagcaag cggcggtcgc catcgccagc cgcgcggctg ggaacagctg      780

ggcggtggcg gtggcagccc caccggtgcc gagttcctgg gcgacggtgg cgatgtgtcc      840

tttagcaccc gtggtaccca gaactggacg gtagagcgcc tgctgcaggc acatcgtcag      900

ctggaagagc gtggctatgt attcgttggc taccacggca cttttctgga agcagctcag      960

tccatcgtgt ttggtggtgt ccgtgcccgt tctcaagacc tggatgcgat ttggcgtggt     1020

ttctacattg caggcgatcc agcgctggca tacggttatg cgcaggacca ggaaccggat     1080

gctcgtggtc gcattcgtaa tggtgcgctg ctgcgcgtat atgtgccgcg ttccagcctg     1140

ccgggcttct accgcactag cctgaccctg gccgcgccgg aggcggcggg tgaagtggaa     1200

cgtctgattg gtcatcctct gcctctgcgc ctggatgcca tcaccggccc agaggaggag     1260

ggcggtcgtc tggaaaccat tctgggctgg ccgctggctg aacgtacggt cgttattccg     1320

agcgcgattc ctaccgatcc tcgtaacgtt ggcggcgatc tggacccatc ttctattcca     1380

gataaggagc aggcaatctc cgcgctgccg gattatgcaa gccaaccggg taaaccacct     1440

cgtgaagatc tgaaataa                                                   1458


<210>  19
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile 
            20                  25                  30          


Gly Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp 
        35                  40                  45              


Val Ala Ser Arg Tyr Thr Gly Asp Gly Gly Ala Val Phe Asp Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe 
65                  70                  75                  80  


Asp Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Gly Pro Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile Gly Tyr Met Ala Trp Phe 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp Val Ala Ser Arg Tyr Thr 
                165                 170                 175     


Gly Asp Gly Gly Ala Val Phe Asp Asp Ala Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe Asp Leu Gln Met Asp Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Lys Gly Pro 
    210                 215                 220                 


Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg Gly Thr Gln Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Leu Lys Ala Ser Gly Gly Arg His Arg Gln Pro Arg Gly 
                245                 250                 255     


Trp Glu Gln Leu Gly Gly Gly Gly Gly Ser Pro Thr Gly Ala Glu Phe 
            260                 265                 270         


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
        275                 280                 285             


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
    290                 295                 300                 


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
305                 310                 315                 320 


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
                325                 330                 335     


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
            340                 345                 350         


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
        355                 360                 365             


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
    370                 375                 380                 


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
385                 390                 395                 400 


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
                405                 410                 415     


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
            420                 425                 430         


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
        435                 440                 445             


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
    450                 455                 460                 


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
465                 470                 475                 480 


Arg Glu Asp Leu Lys 
                485 


<210>  20
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
atgcaggtgc agctggtgga gtctggggga ggcttggtgc agcccggggg gtctctgaga       60

ctctcctgtg tagcctctgg atacagctac agtattggtt acatggcctg gttccgccag      120

gccccaggaa aggagcgcgc gtgggtcgcg tctcgatata ctggtgacgg tggcgcagtc      180

tttgacgacg ccgtgaaggg ccgattcacc acctcccaag agagtgccgg gaacacgttc      240

gatttgcaaa tggacagcct gaaacctgag gacactgcca tgtactattg cgcagcgaaa      300

gggcccggtt tcgggcggtg ggagtactgg ggccggggga cccaggtcac cgtctcctca      360

ggcggcagcc aggtgcagct ggtggagtct gggggaggct tggtgcagcc cggggggtct      420

ctgagactct cctgtgtagc ctctggatac agctacagta ttggttacat ggcctggttc      480

cgccaggccc caggaaagga gcgcgcgtgg gtcgcgtctc gatatactgg tgacggtggc      540

gcagtctttg acgacgccgt gaagggccga ttcaccacct cccaagagag tgccgggaac      600

acgttcgatt tgcaaatgga cagcctgaaa cctgaggaca ctgccatgta ctattgcgca      660

gcgaaagggc ccggtttcgg gcggtgggag tactggggcc gggggaccca ggtcaccgtc      720

tcctcaaagc ttaaagcaag cggcggtcgc catcgccagc cgcgcggctg ggaacagctg      780

ggcggtggcg gtggcagccc caccggtgcc gagttcctgg gcgacggtgg cgatgtgtcc      840

tttagcaccc gtggtaccca gaactggacg gtagagcgcc tgctgcaggc acatcgtcag      900

ctggaagagc gtggctatgt attcgttggc taccacggca cttttctgga agcagctcag      960

tccatcgtgt ttggtggtgt ccgtgcccgt tctcaagacc tggatgcgat ttggcgtggt     1020

ttctacattg caggcgatcc agcgctggca tacggttatg cgcaggacca ggaaccggat     1080

gctcgtggtc gcattcgtaa tggtgcgctg ctgcgcgtat atgtgccgcg ttccagcctg     1140

ccgggcttct accgcactag cctgaccctg gccgcgccgg aggcggcggg tgaagtggaa     1200

cgtctgattg gtcatcctct gcctctgcgc ctggatgcca tcaccggccc agaggaggag     1260

ggcggtcgtc tggaaaccat tctgggctgg ccgctggctg aacgtacggt cgttattccg     1320

agcgcgattc ctaccgatcc tcgtaacgtt ggcggcgatc tggacccatc ttctattcca     1380

gataaggagc aggcaatctc cgcgctgccg gattatgcaa gccaaccggg taaaccacct     1440

cgtgaagatc tgaaataa                                                   1458


<210>  21
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile 
            20                  25                  30          


Gly Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp 
        35                  40                  45              


Val Ala Ser Arg Tyr Thr Gly Asp Gly Gly Ala Val Phe Asp Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe 
65                  70                  75                  80  


Asp Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Gly Pro Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Val Ala Ser Gly Tyr Ser Tyr Ser Ile Gly Tyr Met Ala Trp Phe 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Glu Arg Ala Trp Val Ala Ser Arg Tyr Thr 
                165                 170                 175     


Gly Asp Gly Gly Ala Val Phe Asp Asp Ala Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Thr Ser Gln Glu Ser Ala Gly Asn Thr Phe Asp Leu Gln Met Asp Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Lys Gly Pro 
    210                 215                 220                 


Gly Phe Gly Arg Trp Glu Tyr Trp Gly Arg Gly Thr Gln Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Leu Lys Ala Ser Gly Gly Arg His Arg Gln Pro Arg Gly 
                245                 250                 255     


Trp Glu Gln Leu Gly Gly Gly Gly Gly Ser Pro Thr Gly Ala Glu Phe 
            260                 265                 270         


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
        275                 280                 285             


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
    290                 295                 300                 


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
305                 310                 315                 320 


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
                325                 330                 335     


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
            340                 345                 350         


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
        355                 360                 365             


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
    370                 375                 380                 


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
385                 390                 395                 400 


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
                405                 410                 415     


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
            420                 425                 430         


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
        435                 440                 445             


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
    450                 455                 460                 


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
465                 470                 475                 480 


Arg Glu Asp Leu Lys 
                485 


