                         б

<110>  Ϻͨѧ
 
<120>  һǶϿԭ弰Ӧ

<130>  0104-PA-002

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  266
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv T120

<400>  1

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Thr Arg Asn Gly Asn Tyr Val Asp Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265     


<210>  2
<211>  798
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  scFv T120 (ᣩ

<400>  2
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

accggtgata tccagatgac ccagtccccg agctccctgt ccgcctctgt gggcgatagg      120

gtcactatca cctgcaaagc cagtcaggat gtgagcactg ctgtagcctg gtatcaacag      180

aaacccggac aggccccgcg tctgctgatt tactgggcat ccacccgtca taccggagtc      240

ccttctcgct tctctggttc cggctctggg acggatttca ctctgaccat cagctccctg      300

cagccggaag acttcgcact gtattactgt cagcaacact atagcactcc gtggacgttc      360

ggacagggta ccaagctgga gatcaaaggc ggaggcggat caggcggcgg tggatctggg      420

ggtggcggat ctgaagtaca gctggtggag tctggaggag gcttggtgca acctggagga      480

tccctgcgtc tctcctgtgt tgcctctgga ttcactttca gtaactactg gatgaactgg      540

gtccgccagg cgccaggtaa ggggcttgag tgggttgctg aaattagatt gaaatctaat      600

aattatgcaa cacattatgc ggagtctgtg aaagggaggt tcaccatctc aagagatgat      660

tccaaaaata ccgtctacct gcaaatgaac agcttaagag ctgaagacac tgcggtttat      720

tactgtaccc ggaacggtaa ttacgtggat tatgctatgg actactgggg tcaaggaacc      780

ctggtcaccg tctcctca                                                    798


<210>  3
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR1

<400>  3

Gln Asp Val Ser Thr Ala 
1               5       


<210>  4
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR2

<400>  4

Trp Ala Ser 
1           


<210>  5
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR3

<400>  5

Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  6
<211>  18
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR1ᣩ

<400>  6
caggatgtga gcactgct                                                     18


<210>  7
<211>  9
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR2ᣩ

<400>  7
tgggcatcc                                                                9


<210>  8
<211>  27
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 LCDR3ᣩ

<400>  8
cagcaacact atagcactcc gtggacg                                           27


<210>  9
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 VLᣩ

<400>  10
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcact       60

atcacctgca aagccagtca ggatgtgagc actgctgtag cctggtatca acagaaaccc      120

ggacaggccc cgcgtctgct gatttactgg gcatccaccc gtcataccgg agtcccttct      180

cgcttctctg gttccggctc tgggacggat ttcactctga ccatcagctc cctgcagccg      240

gaagacttcg cactgtatta ctgtcagcaa cactatagca ctccgtggac gttcggacag      300

ggtaccaagc tggagatcaa a                                                321


<210>  11
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR1

<400>  11

Gly Phe Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR2

<400>  12

Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  13
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR3

<400>  13

Thr Arg Asn Gly Asn Tyr Val Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  14
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR1ᣩ

<400>  14
ggattcactt tcagtaacta ctgg                                              24


<210>  15
<211>  30
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR2ᣩ

<400>  15
attagattga aatctaataa ttatgcaaca                                        30


<210>  16
<211>  39
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 HCDR3ᣩ

<400>  16
acccggaacg gtaattacgt ggattatgct atggactac                              39


<210>  17
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T120 VH

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asn Gly Asn Tyr Val Asp Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  366
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T120 VHᣩ

<400>  18
gaagtacagc tggtggagtc tggaggaggc ttggtgcaac ctggaggatc cctgcgtctc       60

tcctgtgttg cctctggatt cactttcagt aactactgga tgaactgggt ccgccaggcg      120

ccaggtaagg ggcttgagtg ggttgctgaa attagattga aatctaataa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaaatacc      240

gtctacctgc aaatgaacag cttaagagct gaagacactg cggtttatta ctgtacccgg      300

aacggtaatt acgtggatta tgctatggac tactggggtc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  19
<211>  269
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv F231

<400>  19

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe 
            20                  25                  30          


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Ile Val Arg Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln 
            100                 105                 110         


His Trp Asn Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Trp Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Tyr Ile Asn Pro Thr Thr Gly Tyr Thr Glu Tyr Thr Gln Lys Phe 
        195                 200                 205             


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ser Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Gly Ser Pro Tyr Tyr Asp Ser Thr Tyr Ser Tyr Trp Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 


<210>  20
<211>  807
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  scFv F231 ᣩ

<400>  20
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

accggtgata tcgtgatgac ccagagccag aagttcatga gcacatccgt gggcgacaga      120

gtgagcatca cctgtaaggc cagccagatc gtgaggaccg ccgtggcctg gtaccagcag      180

aaacccggac aaagccccaa ggccctgatc tacctggcca gcaacagaca taccggcgtg      240

cccgatagat tcaccggcag cggcagcggc accgacttta ccctcaccat ctccaacgtg      300

cagtccgagg atctggccga ctacttctgc ctccagcact ggaactaccc ctttaccttc      360

ggcagcggca ccaagctgga gattaaaggc ggcggcggca gcggcggagg cggaagcgga      420

ggaggcggaa gccaagtgca gctccagcag agcggagccg aactggctaa gcccggcgct      480

agcgtgaaga tgagctgcaa ggccagcggc tacaccttca cctcctactg gatgtactgg      540

ctgaagcaga gacctggcca gggcctggag tggatcggct acatcaaccc caccaccggc      600

tacaccgagt acacccagaa gttcaaggat aaggccaccc tgaccgctga caccagcagc      660

aacagcgctt atatgcagct gtccagcctg accagcgagg actccgccgt gtactactgc      720

gctaggggca gcccttacta cgactccacc tactcctact ggtacttcga cgtgtggggc      780

gccggcacca cagtgacagt gagctcc                                          807


<210>  21
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR1

<400>  21

Gln Ile Val Arg Thr Ala 
1               5       


<210>  22
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR2

<400>  22

Leu Ala Ser 
1           


<210>  23
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR3

<400>  23

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  18
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR1ᣩ

<400>  24
cagatcgtga ggaccgcc                                                     18


<210>  25
<211>  9
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR2ᣩ

<400>  25
ctggccagc                                                                9


<210>  26
<211>  27
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 LCDR3ᣩ

<400>  26
ctccagcact ggaactaccc ctttacc                                           27


<210>  27
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 VL

<400>  27

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ile Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 VLᣩ

<400>  28
gatatcgtga tgacccagag ccagaagttc atgagcacat ccgtgggcga cagagtgagc       60

atcacctgta aggccagcca gatcgtgagg accgccgtgg cctggtacca gcagaaaccc      120

ggacaaagcc ccaaggccct gatctacctg gccagcaaca gacataccgg cgtgcccgat      180

agattcaccg gcagcggcag cggcaccgac tttaccctca ccatctccaa cgtgcagtcc      240

gaggatctgg ccgactactt ctgcctccag cactggaact acccctttac cttcggcagc      300

ggcaccaagc tggagattaa a                                                321


<210>  29
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR1

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR2

<400>  30

Ile Asn Pro Thr Thr Gly Tyr Thr 
1               5               


<210>  31
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR3

<400>  31

Ala Arg Gly Ser Pro Tyr Tyr Asp Ser Thr Tyr Ser Tyr Trp Tyr Phe 
1               5                   10                  15      


Asp Val 
        


<210>  32
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR1ᣩ

<400>  32
ggctacacct tcacctccta ctgg                                              24


<210>  33
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR2ᣩ

<400>  33
atcaacccca ccaccggcta cacc                                              24


<210>  34
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 HCDR3ᣩ

<400>  34
gctaggggca gcccttacta cgactccacc tactcctact ggtacttcga cgtg             54


<210>  35
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F231 VH

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Thr Thr Gly Tyr Thr Glu Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ser Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Pro Tyr Tyr Asp Ser Thr Tyr Ser Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  375
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F231 VHᣩ

<400>  36
caagtgcagc tccagcagag cggagccgaa ctggctaagc ccggcgctag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc tcctactgga tgtactggct gaagcagaga      120

cctggccagg gcctggagtg gatcggctac atcaacccca ccaccggcta caccgagtac      180

acccagaagt tcaaggataa ggccaccctg accgctgaca ccagcagcaa cagcgcttat      240

atgcagctgt ccagcctgac cagcgaggac tccgccgtgt actactgcgc taggggcagc      300

ccttactacg actccaccta ctcctactgg tacttcgacg tgtggggcgc cggcaccaca      360

gtgacagtga gctcc                                                       375


<210>  37
<211>  264
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv 20

<400>  37

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
                165                 170                 175     


Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ala 
            260                 


<210>  38
<211>  45
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  38

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  39
<211>  135
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ᣩ

<400>  39
actacaactc cagctccacg accaccaaca cctgctccaa ccatcgcttc gcagcctctg       60

tccctgcgcc cagaggcatg ccggccagct gcaggaggtg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  40
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ĥ

<400>  40

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  41
<211>  72
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ĥᣩ

<400>  41
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  42
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼ṹ

<400>  42

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  43
<211>  126
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼ṹ򣨺ᣩ

<400>  43
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  44
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ

<400>  44

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  45
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ򣨺ᣩ

<400>  45
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgg                                336


<210>  46
<211>  492
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR T120BBZ

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Thr Arg Asn Gly Asn Tyr Val Asp Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  47
<211>  1479
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR T120BBZ ᣩ

<400>  47
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

accggtgata tccagatgac ccagtccccg agctccctgt ccgcctctgt gggcgatagg      120

gtcactatca cctgcaaagc cagtcaggat gtgagcactg ctgtagcctg gtatcaacag      180

aaacccggac aggccccgcg tctgctgatt tactgggcat ccacccgtca taccggagtc      240

ccttctcgct tctctggttc cggctctggg acggatttca ctctgaccat cagctccctg      300

cagccggaag acttcgcact gtattactgt cagcaacact atagcactcc gtggacgttc      360

ggacagggta ccaagctgga gatcaaaggc ggaggcggat caggcggcgg tggatctggg      420

ggtggcggat ctgaagtaca gctggtggag tctggaggag gcttggtgca acctggagga      480

tccctgcgtc tctcctgtgt tgcctctgga ttcactttca gtaactactg gatgaactgg      540

gtccgccagg cgccaggtaa ggggcttgag tgggttgctg aaattagatt gaaatctaat      600

aattatgcaa cacattatgc ggagtctgtg aaagggaggt tcaccatctc aagagatgat      660

tccaaaaata ccgtctacct gcaaatgaac agcttaagag ctgaagacac tgcggtttat      720

tactgtaccc ggaacggtaa ttacgtggat tatgctatgg actactgggg tcaaggaacc      780

ctggtcaccg tctcctcagc ggccgcaact acaactccag ctccacgacc accaacacct      840

gctccaacca tcgcttcgca gcctctgtcc ctgcgcccag aggcatgccg gccagctgca      900

ggaggtgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcggtaa                            1479


<210>  48
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR 20BBZ

<400>  48

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
                165                 170                 175     


Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ala Ala Ala Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  49
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR 20BBZ ᣩ

<400>  49
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

accggtcaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag      120

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tccactggtt ccagcagaag      180

ccaggctctt cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      240

gttcgcttca gtggcagtgg gtctgggact tcttactctc tcacaatcag cagagtggag      300

gctgaagatg ctgccactta ttactgccag cagtggacta gtaacccacc cacgttcgga      360

ggggggacca agctggaaat caaaggcgga ggcggatcag gcggcggtgg atctgggggt      420

ggcggatctc aggtacaact gcagcagcct ggggctgagc tggtgaagcc tggggcctca      480

gtgaagatgt cctgcaaggc ttctggctac acatttacca gttacaatat gcactgggta      540

aaacagacac ctggtcgggg cctggaatgg attggagcta tttatcccgg aaatggtgat      600

acttcctaca atcagaagtt caaaggcaag gccacattga ctgcagacaa atcctccagc      660

acagcctaca tgcagctcag cagcctgaca tctgaggact ctgcggtcta ttactgtgca      720

agatcgactt actacggcgg tgactggtac ttcaatgtct ggggcgcagg gaccacggtc      780

accgtttctg cagcggccgc aactacaact ccagctccac gaccaccaac acctgctcca      840

accatcgctt cgcagcctct gtccctgcgc ccagaggcat gccggccagc tgcaggaggt      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgg taa                                  1473


<210>  50
<211>  497
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR F231mBBZ

<400>  50

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe 
            20                  25                  30          


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Ile Val Arg Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln 
            100                 105                 110         


His Trp Asn Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Trp Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Tyr Ile Asn Pro Thr Thr Gly Tyr Thr Glu Tyr Thr Gln Lys Phe 
        195                 200                 205             


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ser Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Gly Ser Pro Tyr Tyr Asp Ser Thr Tyr Ser Tyr Trp Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
        275                 280                 285             


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
    290                 295                 300                 


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
                325                 330                 335     


Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
        355                 360                 365             


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
    370                 375                 380                 


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
385                 390                 395                 400 


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
                485                 490                 495     


Arg 
    


<210>  51
<211>  1494
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR F231mBBZ (ᣩ

<400>  51
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

accggtgata tcgtgatgac ccagagccag aagttcatga gcacatccgt gggcgacaga      120

gtgagcatca cctgtaaggc cagccagatc gtgaggaccg ccgtggcctg gtaccagcag      180

aaacccggac aaagccccaa ggccctgatc tacctggcca gcaacagaca taccggcgtg      240

cccgatagat tcaccggcag cggcagcggc accgacttta ccctcaccat ctccaacgtg      300

cagtccgagg atctggccga ctacttctgc ctccagcact ggaactaccc ctttaccttc      360

ggcagcggca ccaagctgga gattaaaggc ggcggcggca gcggcggagg cggaagcgga      420

ggaggcggaa gccaagtgca gctccagcag agcggagccg aactggctaa gcccggcgct      480

agcgtgaaga tgagctgcaa ggccagcggc tacaccttca cctcctactg gatgtactgg      540

ctgaagcaga gacctggcca gggcctggag tggatcggct acatcaaccc caccaccggc      600

tacaccgagt acacccagaa gttcaaggat aaggccaccc tgaccgctga caccagcagc      660

aacagcgctt atatgcagct gtccagcctg accagcgagg actccgccgt gtactactgc      720

gctaggggca gcccttacta cgactccacc tactcctact ggtacttcga cgtgtggggc      780

gccggcacca cagtgacagt gagctccgcg gccgcaacta ctaccaagcc agtgctgcga      840

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      900

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      960

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgcaaa     1020

tggatcagga aaaaattccc ccacatattc aagcaaccat ttaagaagac cactggagca     1080

gctcaagagg aagatgcttg tagctgccga tgtccacagg aagaagaagg aggaggagga     1140

ggctatgagc tgagagcaaa attcagcagg agtgcagaga ctgctgccaa cctgcaggac     1200

cccaaccagc tctacaatga gctcaatcta gggcgaagag aggaatatga cgtcttggag     1260

aagaagcggg ctcgcgaccc agagatggga ggcaaacagc agaggaggag gaacccccag     1320

gaaggcgtat acaatgcact gcagaaagac aagatggcag aagcctacag tgagatcggc     1380

acaaaaggcg agaggcggag aggcaagggg cacgatggcc tttaccaggg tctcagcact     1440

gccaccaagg acacctatga tgccctgcat atgcagaccc tggcccctcg ctaa           1494


<210>  52
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-VH 

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  53
<211>  45
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  (VL-VH)ᣩ

<400>  53
ggcggaggcg gatcaggcgg cggtggatct gggggtggcg gatct                       45


<210>  54
<211>  223
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BBZ

<400>  54

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             


<210>  55
<211>  672
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BBZᣩ

<400>  55
actacaactc cagctccacg accaccaaca cctgctccaa ccatcgcttc gcagcctctg       60

tccctgcgcc cagaggcatg ccggccagct gcaggaggtg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      240

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      300

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      360

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      420

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      480

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      540

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      600

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      660

ccccctcggt aa                                                          672


<210>  56
<211>  225
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mBBZ

<400>  56

Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
1               5                   10                  15      


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
            20                  25                  30          


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
        35                  40                  45              


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
    50                  55                  60                  


Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
65                  70                  75                  80  


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
                85                  90                  95      


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
            100                 105                 110         


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
        115                 120                 125             


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    130                 135                 140                 


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
145                 150                 155                 160 


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
                165                 170                 175     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
            180                 185                 190         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        195                 200                 205             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
    210                 215                 220                 


Arg 
225 


<210>  57
<211>  678
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mBBZᣩ

<400>  57
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag       60

ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc      120

gcctgtgata tttacatctg ggcacccttg gccggaatct gcgtggccct tctgctgtcc      180

ttgatcatca ctctcatctg caaatggatc aggaaaaaat tcccccacat attcaagcaa      240

ccatttaaga agaccactgg agcagctcaa gaggaagatg cttgtagctg ccgatgtcca      300

caggaagaag aaggaggagg aggaggctat gagctgagag caaaattcag caggagtgca      360

gagactgctg ccaacctgca ggaccccaac cagctctaca atgagctcaa tctagggcga      420

agagaggaat atgacgtctt ggagaagaag cgggctcgcg acccagagat gggaggcaaa      480

cagcagagga ggaggaaccc ccaggaaggc gtatacaatg cactgcagaa agacaagatg      540

gcagaagcct acagtgagat cggcacaaaa ggcgagaggc ggagaggcaa ggggcacgat      600

ggcctttacc agggtctcag cactgccacc aaggacacct atgatgccct gcatatgcag      660

accctggccc ctcgctaa                                                    678


<210>  58
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  J18ˣ

<400>  58

Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu 
1               5                   10                  15      


Thr Val Trp Pro Phe 
            20      


<210>  59
<211>  135
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  V24J18ˣ

<400>  59

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly 
        115                 120                 125             


Thr Gln Leu Thr Val Trp Pro 
    130                 135 


<210>  60
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  V8

<400>  60

Glu Ala Ala Val Thr Gln Ser Pro Arg Asn Lys Val Ala Val Thr Gly 
1               5                   10                  15      


Gly Lys Val Thr Leu Ser Cys Asn Gln Thr Asn Asn His Asn Asn Met 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Tyr Gly Ala Gly Ser Thr Glu Lys Gly Asp Ile Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu Glu Leu 
65                  70                  75                  80  


Ala Thr Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Gly Asp Trp 
                85                  90                  95      


Phe Ser Gln Asn Thr Leu Tyr Phe Gly Ala Gly Thr Arg Leu Ser Val 
            100                 105                 110         


Leu 
    


<210>  61
<211>  96
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  V8ˣ

<400>  61

Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
1               5                   10                  15      


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
            20                  25                  30          


Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
        35                  40                  45              


Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
    50                  55                  60                  


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Leu 
                85                  90                  95      


<210>  62
<211>  264
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1168scFv  

<400>  62

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Ser Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


His Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                165                 170                 175     


Met His Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe Leu 
    210                 215                 220                 


Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Arg Pro Met Gly Gly Ala Gly Gly Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser 
            260                 


<210>  63
<211>  792
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  1168scFv 

<400>  63
atggagaccg acaccctctt attatgggtg ctgttattat gggtccccgg aagcaccgga       60

accggtcaga ttgtgctgac ccagagcccc gctatcatga gcgcctcccc cggcgagaag      120

gtgaccatca gctgctccgc cagcagcagc gtgagctaca tctactggta ccagcagaag      180

cctggaagca gccccaagcc ttggatctat agaacatcca atctggccag cggcgtgccc      240

gccagattta gcggctccgg cagcggcaca tcctactctc tgacaatcag ctccatggag      300

gctgaagatg ccgccgccta ctattgccag cagtaccaca cctaccctct gacatttggc      360

gccggcacca agctggagct caaaggcggc ggaggaagcg gaggaggagg cagcggagga      420

ggcggaagcg atgtgcagct ggtggaatcc ggaggcggac tggtgcaacc cggcggctct      480

aggaagctga gctgcgctgc cagcggcttc accttctcct ccttcggcat gcactgggtg      540

agacaagtgc ccgagaaagg actggagtgg gtggcctaca tctcctccgg cagctccacc      600

atctactacg ccgacaccgt caagggaaga ttcaccatct ctagggacaa ccccaagaac      660

acactgtttc tgcagatgac atctctgaga agcgaggaca cagccatgta ctactgcgcc      720

agaagaccta tgggcggagc tggcggcgcc atggattact ggggacaagg cacctccgtg      780

accgtgtcca gc                                                          792

<210>  64
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 LCDR1

<400>  64

Ser Ala Ser Ser Ser Val Ser Tyr Ile Tyr 
1               5                   10  


<210>  65
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 LCDR2

<400>  65

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SCFV1168 LCDR3

<400>  66

Gln Gln Tyr His Thr Tyr Pro Leu Thr 
1               5                   


<210>  67
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 HCDR1

<400>  67

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  68
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 HCDR2

<400>  68

Ser Ser Gly Ser Ser Thr 
1               5       


<210>  69
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 HCDR3

<400>  69

Arg Pro Met Gly Gly Ala Gly Gly Ala Met Asp Tyr 
1               5                   10          


<210>  70
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 ɱ

<400>  70

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ala Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  71
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv1168 ɱ

<400>  71

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Pro Met Gly Gly Ala Gly Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  72
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR 1168BBZȫ

<400>  72

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Ser Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


His Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                165                 170                 175     


Met His Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe Leu 
    210                 215                 220                 


Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Arg Pro Met Gly Gly Ala Gly Gly Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  73
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR 1168BBZȫ

<400>  73
atggagaccg acaccctctt attatgggtg ctgttattat gggtccccgg aagcaccgga       60

accggtcaga ttgtgctgac ccagagcccc gctatcatga gcgcctcccc cggcgagaag      120

gtgaccatca gctgctccgc cagcagcagc gtgagctaca tctactggta ccagcagaag      180

cctggaagca gccccaagcc ttggatctat agaacatcca atctggccag cggcgtgccc      240

gccagattta gcggctccgg cagcggcaca tcctactctc tgacaatcag ctccatggag      300

gctgaagatg ccgccgccta ctattgccag cagtaccaca cctaccctct gacatttggc      360

gccggcacca agctggagct caaaggcggc ggaggaagcg gaggaggagg cagcggagga      420

ggcggaagcg atgtgcagct ggtggaatcc ggaggcggac tggtgcaacc cggcggctct      480

aggaagctga gctgcgctgc cagcggcttc accttctcct ccttcggcat gcactgggtg      540

agacaagtgc ccgagaaagg actggagtgg gtggcctaca tctcctccgg cagctccacc      600

atctactacg ccgacaccgt caagggaaga ttcaccatct ctagggacaa ccccaagaac      660

acactgtttc tgcagatgac atctctgaga agcgaggaca cagccatgta ctactgcgcc      720

agaagaccta tgggcggagc tggcggcgcc atggattact ggggacaagg cacctccgtg      780

accgtgtcca gcgcggccgc aactacaact ccagctccac gaccaccaac acctgctcca      840

accatcgctt cgcagcctct gtccctgcgc ccagaggcat gccggccagc tgcaggaggt      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgg taa                                  1473
