                         SEQUENCE LISTING

<110>  Ŵҩݣ޹˾
 
<120>  PD-L1Ϳ弰;

<130>  PF 190802PCT

<160>  45    

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  1

Ala Tyr Thr Ile Ser Arg Asn Ser Met Gly 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2

Ala Asp Pro Met Ser Arg Asn Ser Met Gly 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3

Asp Asn Pro Met Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  4

Ala Ile Glu Ser Asp Gly Ser Thr Ser 
1               5                   


<210>  5
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5

Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala Phe 
1               5                   10                  15      


Met Thr Leu Pro Ala Leu Asn Tyr 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6

Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala Phe 
1               5                   10                  15      


Met Thr Leu Gln Asp Leu Asn Asp 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7

Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala Phe 
1               5                   10                  15      


Met Ile Leu Gln Asp Leu Asn Tyr 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8

Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala Phe 
1               5                   10                  15      


Met Ile Leu Ala Asp Leu Asn Asp 
            20                  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala 
1               5                   10                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  11

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  12

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  13
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  14
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Asp Pro Met Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  15
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Asn Pro Met Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  16
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Gln Asp Leu Asn Asp Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  17
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Ile Leu Gln Asp Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  18
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Ile Leu Ala Asp Leu Asn Asp Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  19
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  20
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Asp Pro Met Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  21
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Asn Pro Met Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Pro Ala Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  22
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Thr Leu Gln Asp Leu Asn Asp Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  23
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Ile Leu Gln Asp Leu Asn Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  24
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Ile Ser Arg Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu Ala 
            100                 105                 110         


Phe Met Ile Leu Ala Asp Leu Asn Asp Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  25
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  25

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  26
<211>  4827
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  26
acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt     60

cctcgtcttc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga    120

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac    180

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga    240

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat    300

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc    360

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac    420

ctctatactt taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac    480

gactcactat agggaatatt aagctaattc cctacttcat acattttcaa ttaagatgca    540

gttacttcgc tgtttttcaa tattttctgt tattgcttca gttttagcag gatcctgaca    600

tagtagggat tataaggagg cggtggatcc gattacaagg atgacgatga caagggcgga    660

ggaggctccc aggaactgac aactatatgc gagcaaatcc cctcaccaac tttagaatcg    720

acgccgtact ctttgtcaac gactactatt ttggccaacg ggaaggcaat gcaaggagtt    780

tttgaatatt acaaatcagt aacgtttgtc agtaattgcg gttctcaccc ctcaacgact    840

agcaaaggca gccccataaa cacacagtat gttttttaat gagtttaaac ccgctgatct    900

gataacaaca gtgtagatgt aacaaaatcg actttgttcc cactgtactt ttagctcgta    960

caaaatacaa tatacttttc atttctccgt aaacaacatg ttttcccatg taatatcctt   1020

ttctattttt cgttccgtta ccaactttac acatacttta tatagctatt cacttctata   1080

cactaaaaaa ctaagacaat tttaattttg ctgcctgcca tatttcaatt tgttataaat   1140

tcctataatt tatcctatta gtagctaaaa aaagatgaat gtgaatcgaa tcctaagaga   1200

attgggcaag tgcacaaaca atacttaaat aaatactact cagtaataac ctatttctta   1260

gcatttttga cgaaatttgc tattttgtta gagtctttta caccatttgt ctccacacct   1320

ccgcttacat caacaccaat aacgccattt aatctaagcg catcaccaac attttctggc   1380

gtcagtccac cagctaacat aaaatgtaag ctctcggggc tctcttgcct tccaacccag   1440

tcagaaatcg agttccaatc caaaagttca cctgtcccac ctgcttctga atcaaacaag   1500

ggaataaacg aatgaggttt ctgtgaagct gcactgagta gtatgttgca gtcttttgga   1560

aatacgagtc ttttaataac tggcaaaccg aggaactctt ggtattcttg ccacgactca   1620

tctccgtgca gttggacgat atcaatgccg taatcattga ccagagccaa aacatcctcc   1680

ttaggttgat tacgaaacac gccaaccaag tatttcggag tgcctgaact atttttatat   1740

gcttttacaa gacttgaaat tttccttgca ataaccgggt caattgttct ctttctattg   1800

ggcacacata taatacccag caagtcagca tcggaatcta gagcacattc tgcggcctct   1860

gtgctctgca agccgcaaac tttcaccaat ggaccagaac tacctgtgaa attaataaca   1920

gacatactcc aagctgcctt tgtgtgctta atcacgtata ctcacgtgct caatagtcac   1980

caatgccctc cctcttggcc ctctcctttt cttttttcga ccgaatttct tgaagacgaa   2040

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttagg   2100

acggatcgct tgcctgtaac ttacacgcgc ctcgtatctt ttaatgatgg aataatttgg   2160

gaatttactc tgtgtttatt tatttttatg ttttgtattt ggattttaga aagtaaataa   2220

agaaggtaga agagttacgg aatgaagaaa aaaaaataaa caaaggttta aaaaatttca   2280

acaaaaagcg tactttacat atatatttat tagacaagaa aagcagatta aatagatata   2340

cattcgatta acgataagta aaatgtaaaa tcacaggatt ttcgtgtgtg gtcttctaca   2400

cagacaagat gaaacaattc ggcattaata cctgagagca ggaagagcaa gataaaaggt   2460

agtatttgtt ggcgatcccc ctagagtctt ttacatcttc ggaaaacaaa aactattttt   2520

tctttaattt ctttttttac tttctatttt taatttatat atttatatta aaaaatttaa   2580

attataatta tttttatagc acgtgatgaa aaggacccag gtggcacttt tcggggaaat   2640

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg   2700

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa   2760

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac   2820

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac   2880

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt   2940

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc   3000

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca   3060

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc   3120

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag   3180

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa   3240

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg   3300

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa   3360

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg   3420

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt   3480

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacgggcagt   3540

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag   3600

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat   3660

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct   3720

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct   3780

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca   3840

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc   3900

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc   3960

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct   4020

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag   4080

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc   4140

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg   4200

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag   4260

cttccagggg ggaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt   4320

gagcgtcgat ttttgtgatg ctcgtcaggg gggccgagcc tatggaaaaa cgccagcaac   4380

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg   4440

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc   4500

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata   4560

cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt   4620

cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttacct cactcattag   4680

gcaccccagg ctttacactt tatgcttccg gctcctatgt tgtgtggaat tgtgagcgga   4740

taacaatttc acacaggaaa cagctatgac catgattacg ccaagctcgg aattaaccct   4800

cactaaaggg aacaaaagct ggctagt                                       4827


<210>  27
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  27
catgttgttt acggagaaat gaaaagtata ttgtattttg tacgagc                   47


<210>  28
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  28
cggtttgtat tacttcttat tcaaatg                                         27


<210>  29
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  29
gttattgctt cagttttagc acaggtgcag ctgcaggaat cag                       43


<210>  30
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  30
gtcatcgtca tccttgtaat cggatccacc gcctccgcta gacactgtca cgagggttc      59


<210>  31
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<400>  31
gagactgtct tgcgccgcca gcnnknnknn knnknnknnk nnknnknnkg gttggttcag     60

acaggcccca gg                                                         72


<210>  32
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n is a, c, g, or t

<400>  32
gactggaagg agtggcagct nnknnknnkn nknnknnknn kagctacagc gatagcgtga     60

agg                                                                   63


<210>  33
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n is a, c, g, or t

<400>  33
ccgtgtacta ttgcgccgct nnknnknnkn nknnknnknn knnkaccgct ctgggacatc     60

tggc                                                                  64


<210>  34
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<400>  34
caaagtggga ctgggaccta gannknnknn knnknnknnk nnknnkatga ccctgccagc     60

actgaac                                                               67


<210>  35
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<400>  35
gctctgggac atctggcctt cnnknnknnk nnknnknnkn nknnktgggg ccagggaacc     60

ctcgtg                                                                66


<210>  36
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  36
gctggcggcg caagacagtc tc                                              22


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  37
agctgccact ccttccagtc                                                 20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  38
agcggcgcaa tagtacacgg                                                 20


<210>  39
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  39
tctaggtccc agtcccactt tg                                              22


<210>  40
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  40
gaaggccaga tgtcccagag c                                               21


<210>  41
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  41

Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asp Ser Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Gly Trp Tyr Ala Ala Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  42
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Leu Pro Ala Phe 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  43

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly 
1               5                   10                  15                           20    
  

Gly Ser Thr Gly 
            20  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)
<223>  Xaa can be A or D

<220>
<221>  misc_feature
<222>  (2)
<223>  Xaa can be Y or D

<220>
<221>  misc_feature
<222>  ()
<223>  Xaa can be T or P

<220>
<221>  misc_feature
<222>  (4)
<223>  Xaa can be I or M

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be M or A

<400>  44

Xaa Xaa Xaa Xaa Ser Arg Asn Ser Xaa Gly 
1               5                   10  


<210>  45
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be T or I

<220>
<221>  misc_feature
<222>  (22)
<223>  Xaa can be P, Q or A

<220>
<221>  misc_feature
<222>  (23)
<223>  Xaa can be A or D

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be Y or D

<400>  45

Ala Ala Pro Lys Val Gly Leu Gly Pro Arg Thr Ala Leu Gly His Leu 
1               5                   10                  15      


Ala Phe Met Xaa Leu Xaa Xaa Leu Asn Xaa 
            20                  25      


