                               SEQUENCE LISTING

<110> BERG LLC
      THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
      MILITARY MEDICINE, INC.
 
<120> MARKERS FOR THE DIAGNOSIS OF BIOCHEMICAL RECURRENCE IN PROSTATE 
      CANCER

<130> 119992-19220

<140>
<141>

<150> 62/801,963
<151> 2019-02-06

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 2201
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210> 2
<211> 396
<212> PRT
<213> Homo sapiens

<400> 2
Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Ser Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210> 3
<211> 372
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Thr Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser 
            340                 345                 350         


Tyr Ser Ala Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr 
        355                 360                 365             


Glu Gly Thr Arg 
    370         


<210> 4
<211> 732
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Glu Thr Ser Arg Thr Ala Phe Gly Gly Arg Arg Ala Val Pro 
1               5                   10                  15      


Pro Asn Asn Ser Asn Ala Ala Glu Asp Asp Leu Pro Thr Val Glu Leu 
            20                  25                  30          


Gln Gly Val Val Pro Arg Gly Val Asn Leu Gln Glu Phe Leu Asn Val 
        35                  40                  45              


Thr Ser Val His Leu Phe Lys Glu Arg Trp Asp Thr Asn Lys Val Asp 
    50                  55                  60                  


His His Thr Asp Lys Tyr Glu Asn Asn Lys Leu Ile Val Arg Arg Gly 
65                  70                  75                  80  


Gln Ser Phe Tyr Val Gln Ile Asp Phe Ser Arg Pro Tyr Asp Pro Arg 
                85                  90                  95      


Arg Asp Leu Phe Arg Val Glu Tyr Val Ile Gly Arg Tyr Pro Gln Glu 
            100                 105                 110         


Asn Lys Gly Thr Tyr Ile Pro Val Pro Ile Val Ser Glu Leu Gln Ser 
        115                 120                 125             


Gly Lys Trp Gly Ala Lys Ile Val Met Arg Glu Asp Arg Ser Val Arg 
    130                 135                 140                 


Leu Ser Ile Gln Ser Ser Pro Lys Cys Ile Val Gly Lys Phe Arg Met 
145                 150                 155                 160 


Tyr Val Ala Val Trp Thr Pro Tyr Gly Val Leu Arg Thr Ser Arg Asn 
                165                 170                 175     


Pro Glu Thr Asp Thr Tyr Ile Leu Phe Asn Pro Trp Cys Glu Asp Asp 
            180                 185                 190         


Ala Val Tyr Leu Asp Asn Glu Lys Glu Arg Glu Glu Tyr Val Leu Asn 
        195                 200                 205             


Asp Ile Gly Val Ile Phe Tyr Gly Glu Val Asn Asp Ile Lys Thr Arg 
    210                 215                 220                 


Ser Trp Ser Tyr Gly Gln Phe Glu Asp Gly Ile Leu Asp Thr Cys Leu 
225                 230                 235                 240 


Tyr Val Met Asp Arg Ala Gln Met Asp Leu Ser Gly Arg Gly Asn Pro 
                245                 250                 255     


Ile Lys Val Ser Arg Val Gly Ser Ala Met Val Asn Ala Lys Asp Asp 
            260                 265                 270         


Glu Gly Val Leu Val Gly Ser Trp Asp Asn Ile Tyr Ala Tyr Gly Val 
        275                 280                 285             


Pro Pro Ser Ala Trp Thr Gly Ser Val Asp Ile Leu Leu Glu Tyr Arg 
    290                 295                 300                 


Ser Ser Glu Asn Pro Val Arg Tyr Gly Gln Cys Trp Val Phe Ala Gly 
305                 310                 315                 320 


Val Phe Asn Thr Phe Leu Arg Cys Leu Gly Ile Pro Ala Arg Ile Val 
                325                 330                 335     


Thr Asn Tyr Phe Ser Ala His Asp Asn Asp Ala Asn Leu Gln Met Asp 
            340                 345                 350         


Ile Phe Leu Glu Glu Asp Gly Asn Val Asn Ser Lys Leu Thr Lys Asp 
        355                 360                 365             


Ser Val Trp Asn Tyr His Cys Trp Asn Glu Ala Trp Met Thr Arg Pro 
    370                 375                 380                 


Asp Leu Pro Val Gly Phe Gly Gly Trp Gln Ala Val Asp Ser Thr Pro 
385                 390                 395                 400 


Gln Glu Asn Ser Asp Gly Met Tyr Arg Cys Gly Pro Ala Ser Val Gln 
                405                 410                 415     


Ala Ile Lys His Gly His Val Cys Phe Gln Phe Asp Ala Pro Phe Val 
            420                 425                 430         


Phe Ala Glu Val Asn Ser Asp Leu Ile Tyr Ile Thr Ala Lys Lys Asp 
        435                 440                 445             


Gly Thr His Val Val Glu Asn Val Asp Ala Thr His Ile Gly Lys Leu 
    450                 455                 460                 


Ile Val Thr Lys Gln Ile Gly Gly Asp Gly Met Met Asp Ile Thr Asp 
465                 470                 475                 480 


Thr Tyr Lys Phe Gln Glu Gly Gln Glu Glu Glu Arg Leu Ala Leu Glu 
                485                 490                 495     


Thr Ala Leu Met Tyr Gly Ala Lys Lys Pro Leu Asn Thr Glu Gly Val 
            500                 505                 510         


Met Lys Ser Arg Ser Asn Val Asp Met Asp Phe Glu Val Glu Asn Ala 
        515                 520                 525             


Val Leu Gly Lys Asp Phe Lys Leu Ser Ile Thr Phe Arg Asn Asn Ser 
    530                 535                 540                 


His Asn Arg Tyr Thr Ile Thr Ala Tyr Leu Ser Ala Asn Ile Thr Phe 
545                 550                 555                 560 


Tyr Thr Gly Val Pro Lys Ala Glu Phe Lys Lys Glu Thr Phe Asp Val 
                565                 570                 575     


Thr Leu Glu Pro Leu Ser Phe Lys Lys Glu Ala Val Leu Ile Gln Ala 
            580                 585                 590         


Gly Glu Tyr Met Gly Gln Leu Leu Glu Gln Ala Ser Leu His Phe Phe 
        595                 600                 605             


Val Thr Ala Arg Ile Asn Glu Thr Arg Asp Val Leu Ala Lys Gln Lys 
    610                 615                 620                 


Ser Thr Val Leu Thr Ile Pro Glu Ile Ile Ile Lys Val Arg Gly Thr 
625                 630                 635                 640 


Gln Val Val Gly Ser Asp Met Thr Val Thr Val Glu Phe Thr Asn Pro 
                645                 650                 655     


Leu Lys Glu Thr Leu Arg Asn Val Trp Val His Leu Asp Gly Pro Gly 
            660                 665                 670         


Val Thr Arg Pro Met Lys Lys Met Phe Arg Glu Ile Arg Pro Asn Ser 
        675                 680                 685             


Thr Val Gln Trp Glu Glu Val Cys Arg Pro Trp Val Ser Gly His Arg 
    690                 695                 700                 


Lys Leu Ile Ala Ser Met Ser Ser Asp Ser Leu Arg His Val Tyr Gly 
705                 710                 715                 720 


Glu Leu Asp Val Gln Ile Gln Arg Arg Pro Ser Met 
                725                 730         


<210> 5
<211> 326
<212> PRT
<213> Homo sapiens

<400> 5
Met Thr Gly Leu Cys Gly Tyr Ser Ala Pro Asp Met Arg Gly Leu Arg 
1               5                   10                  15      


Leu Ile Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His 
            20                  25                  30          


Pro Val Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His 
        35                  40                  45              


Phe Pro Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser 
    50                  55                  60                  


Cys Gln Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala 
65                  70                  75                  80  


Pro Leu Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu 
                85                  90                  95      


Glu Ala Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr 
            100                 105                 110         


Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg 
        115                 120                 125             


Gly Leu Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala 
    130                 135                 140                 


Leu Ala Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly 
145                 150                 155                 160 


Arg Val Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu 
                165                 170                 175     


Gln Ala Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe 
            180                 185                 190         


Tyr Asn Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly 
        195                 200                 205             


Lys Ala Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp 
    210                 215                 220                 


Leu Leu Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala 
225                 230                 235                 240 


Ile Ser Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu 
                245                 250                 255     


Ile Gln Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu 
            260                 265                 270         


Thr Thr Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu 
        275                 280                 285             


Glu Thr Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala 
    290                 295                 300                 


Pro Tyr Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly 
305                 310                 315                 320 


Ala Gly Ser Leu Glu Ile 
                325     


<210> 6
<211> 870
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Arg Leu Asn Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly 
1               5                   10                  15      


Lys Val His Leu Val Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg 
            20                  25                  30          


Arg His Arg Ile Leu Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly 
        35                  40                  45              


Ser Leu Glu Leu Tyr Leu Asp Cys Ile Gln Val Asp Ser Val His Asn 
    50                  55                  60                  


Leu Pro Arg Ala Phe Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu 
65                  70                  75                  80  


Leu Arg Thr Phe Gln Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys 
                85                  90                  95      


Leu Val Val Arg Gly Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys 
            100                 105                 110         


Phe Leu Gln Gln Ser Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe 
        115                 120                 125             


Asn Arg Gln Phe Leu Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly 
    130                 135                 140                 


Glu Val Lys Asp Leu Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu 
145                 150                 155                 160 


Arg Asn Thr Ile Ala Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln 
                165                 170                 175     


Ser Pro Thr Pro Ser Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro 
            180                 185                 190         


Thr Arg Pro Pro Arg Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val 
        195                 200                 205             


Gln Cys Thr Asp Ser Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu 
    210                 215                 220                 


Gly Tyr Thr Gly Asn Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys 
225                 230                 235                 240 


Tyr His Pro Cys Tyr Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly 
                245                 250                 255     


Phe Arg Cys Asp Ala Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln 
            260                 265                 270         


Gly Val Gly Ile Ser Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp 
        275                 280                 285             


Ile Asp Glu Cys Arg Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val 
    290                 295                 300                 


Asn Thr Leu Gly Ser Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr 
305                 310                 315                 320 


Gly Asp Gln Ile Arg Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro 
                325                 330                 335     


Glu Leu Asn Pro Cys Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln 
            340                 345                 350         


Gly Asp Val Thr Cys Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr 
        355                 360                 365             


Ile Cys Gly Lys Asp Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu 
    370                 375                 380                 


Pro Cys Ser Ala Arg Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro 
385                 390                 395                 400 


Asn Ser Gly Gln Glu Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys 
                405                 410                 415     


Asp Glu Asp Ala Asp Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys 
            420                 425                 430         


Val Leu Ile His Asn Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe 
        435                 440                 445             


Gly Asp Ala Cys Asp Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys 
    450                 455                 460                 


Asp Thr Asp Gly Asp Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp 
465                 470                 475                 480 


Gly Asp Gly Ile Lys Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn 
                485                 490                 495     


Arg Asp Gln Arg Asp Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp 
            500                 505                 510         


Ser Cys Pro Asp Val Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp 
        515                 520                 525             


Leu Val Gly Asp Ser Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly 
    530                 535                 540                 


His Gln Asp Ser Thr Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln 
545                 550                 555                 560 


Leu Asp Thr Asp Lys Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp 
                565                 570                 575     


Asp Asn Asp Gly Ile Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys 
            580                 585                 590         


Arg Leu Val Pro Asn Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val 
        595                 600                 605             


Gly Asp Ile Cys Glu Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg 
    610                 615                 620                 


Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg 
625                 630                 635                 640 


Ala Tyr Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp 
                645                 650                 655     


Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met 
            660                 665                 670         


Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val 
        675                 680                 685             


Asp Phe Glu Gly Thr Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr 
    690                 695                 700                 


Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val 
705                 710                 715                 720 


Met Trp Lys Gln Thr Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg 
                725                 730                 735     


Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr 
            740                 745                 750         


Gly Pro Gly Glu His Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr 
        755                 760                 765             


Ser Asp Gln Val Arg Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp 
    770                 775                 780                 


Lys Asp Lys Val Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val 
785                 790                 795                 800 


Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp 
                805                 810                 815     


Ser Gly Val Thr Ile Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val 
            820                 825                 830         


Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg 
        835                 840                 845             


Cys Asn Asp Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn 
    850                 855                 860                 


Phe Asp Arg Phe Asp Asn 
865                 870 


<210> 7
<211> 220
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210> 8
<211> 298
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Thr Leu Gln Ser Thr Leu Leu Leu Leu Leu Leu Val Pro Leu 
1               5                   10                  15      


Ile Lys Pro Ala Pro Pro Thr Gln Gln Asp Ser Arg Ile Ile Tyr Asp 
            20                  25                  30          


Tyr Gly Thr Asp Asn Phe Glu Glu Ser Ile Phe Ser Gln Asp Tyr Glu 
        35                  40                  45              


Asp Lys Tyr Leu Asp Gly Lys Asn Ile Lys Glu Lys Glu Thr Val Ile 
    50                  55                  60                  


Ile Pro Asn Glu Lys Ser Leu Gln Leu Gln Lys Asp Glu Ala Ile Thr 
65                  70                  75                  80  


Pro Leu Pro Pro Lys Lys Glu Asn Asp Glu Met Pro Thr Cys Leu Leu 
                85                  90                  95      


Cys Val Cys Leu Ser Gly Ser Val Tyr Cys Glu Glu Val Asp Ile Asp 
            100                 105                 110         


Ala Val Pro Pro Leu Pro Lys Glu Ser Ala Tyr Leu Tyr Ala Arg Phe 
        115                 120                 125             


Asn Lys Ile Lys Lys Leu Thr Ala Lys Asp Phe Ala Asp Ile Pro Asn 
    130                 135                 140                 


Leu Arg Arg Leu Asp Phe Thr Gly Asn Leu Ile Glu Asp Ile Glu Asp 
145                 150                 155                 160 


Gly Thr Phe Ser Lys Leu Ser Leu Leu Glu Glu Leu Ser Leu Ala Glu 
                165                 170                 175     


Asn Gln Leu Leu Lys Leu Pro Val Leu Pro Pro Lys Leu Thr Leu Phe 
            180                 185                 190         


Asn Ala Lys Tyr Asn Lys Ile Lys Ser Arg Gly Ile Lys Ala Asn Ala 
        195                 200                 205             


Phe Lys Lys Leu Asn Asn Leu Thr Phe Leu Tyr Leu Asp His Asn Ala 
    210                 215                 220                 


Leu Glu Ser Val Pro Leu Asn Leu Pro Glu Ser Leu Arg Val Ile His 
225                 230                 235                 240 


Leu Gln Phe Asn Asn Ile Ala Ser Ile Thr Asp Asp Thr Phe Cys Lys 
                245                 250                 255     


Ala Asn Asp Thr Ser Tyr Ile Arg Asp Arg Ile Glu Glu Ile Arg Leu 
            260                 265                 270         


Glu Gly Asn Pro Ile Val Leu Gly Lys His Pro Asn Ser Phe Ile Cys 
        275                 280                 285             


Leu Lys Arg Leu Pro Ile Gly Ser Tyr Phe 
    290                 295             


<210> 9
<211> 999
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210> 10
<211> 194
<212> PRT
<213> Homo sapiens

<400> 10
Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210> 11
<211> 466
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr 
            20                  25                  30          


Arg Asp Met Pro Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln 
        35                  40                  45              


Glu Glu Ala His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe 
    50                  55                  60                  


Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu 
65                  70                  75                  80  


Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg 
                85                  90                  95      


Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser 
            100                 105                 110         


Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr 
        115                 120                 125             


Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His 
    130                 135                 140                 


Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 
145                 150                 155                 160 


Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu 
                165                 170                 175     


Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu 
            180                 185                 190         


Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys 
        195                 200                 205             


Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys 
    210                 215                 220                 


Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly 
225                 230                 235                 240 


Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp 
                245                 250                 255     


Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp 
            260                 265                 270         


Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val 
        275                 280                 285             


Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala 
    290                 295                 300                 


Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro 
305                 310                 315                 320 


Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val 
                325                 330                 335     


Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala 
            340                 345                 350         


Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln 
        355                 360                 365             


Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr 
    370                 375                 380                 


Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys 
385                 390                 395                 400 


Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp 
                405                 410                 415     


Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly 
            420                 425                 430         


His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln 
        435                 440                 445             


Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro 
    450                 455                 460                 


Phe Pro 
465     


<210> 12
<211> 432
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile 
    50                  55                  60                  


Arg Asn Ser Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln 
65                  70                  75                  80  


Thr Ser Ser Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp 
                85                  90                  95      


Gln Lys Arg Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu 
            100                 105                 110         


Tyr Ser Ser Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val 
        115                 120                 125             


Asn Ser Asn Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu 
    130                 135                 140                 


Asn Leu Arg Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln 
145                 150                 155                 160 


Met Glu Tyr Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val 
                165                 170                 175     


Val Ser Gly Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr 
            180                 185                 190         


Ser Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg 
        195                 200                 205             


Val Tyr Cys Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln 
    210                 215                 220                 


Asn Arg Gln Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr 
225                 230                 235                 240 


Lys Gln Gly Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr 
                245                 250                 255     


Cys Gly Leu Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln 
            260                 265                 270         


Leu Thr Arg Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp 
        275                 280                 285             


Lys Gly Asp Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn 
    290                 295                 300                 


Glu Ala Asn Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala 
305                 310                 315                 320 


Gly Asn Ala Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg 
                325                 330                 335     


Thr Met Thr Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp 
            340                 345                 350         


Asn Asp Gly Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu 
        355                 360                 365             


Asp Gly Gly Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn 
    370                 375                 380                 


Gly Arg Tyr Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His 
385                 390                 395                 400 


Gly Thr Asp Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr 
                405                 410                 415     


Ser Met Arg Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
            420                 425                 430         


<210> 13
<211> 93
<212> PRT
<213> Homo sapiens

<400> 13
Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210> 14
<211> 381
<212> PRT
<213> Homo sapiens

<400> 14
Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro 
1               5                   10                  15      


Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His 
            100                 105                 110         


Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu 
145                 150                 155                 160 


Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly 
                245                 250                 255     


Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met 
            260                 265                 270         


Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys 
    290                 295                 300                 


His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu 
        355                 360                 365             


Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys 
    370                 375                 380     


<210> 15
<211> 308
<212> PRT
<213> Homo sapiens

<400> 15
Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210> 16
<211> 1428
<212> PRT
<213> Homo sapiens

<400> 16
Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala 
        355                 360                 365             


Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp 
705                 710                 715                 720 


Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr 
                725                 730                 735     


Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln 
    930                 935                 940                 


Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Thr Tyr Thr  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Thr Leu Thr Ala  Tyr Ile Val 
    1040                 1045                 1050             


Thr Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Thr Leu Ala  Leu Ile Thr Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Thr Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Thr 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Thr Gln Asp Thr Thr  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Thr  Glu Arg Thr 
    1190                 1195                 1200             


Asn Ile  Gln Val Thr Val Thr  Gly Pro Ser Ser Pro  Ser Pro Leu 
    1205                 1210                 1215             


Ala Val  Val Gln Pro Thr Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1220                 1225                 1230             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1235                 1240                 1245             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1250                 1255                 1260             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1265                 1270                 1275             


His Val  Asp Leu Asn Val Cys  Thr Ser Phe Ser Gly  Pro Gly Arg 
    1280                 1285                 1290             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1295                 1300                 1305             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Thr Val  Lys Lys Val 
    1310                 1315                 1320             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1325                 1330                 1335             


Glu Thr  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1340                 1345                 1350             


Val Ser  Asn Thr Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1355                 1360                 1365             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1370                 1375                 1380             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1385                 1390                 1395             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1400                 1405                 1410             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1415                 1420                 1425             


<210> 17
<211> 279
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210> 18
<211> 135
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Thr Pro Ser 
            20                  25                  30          


Thr Cys Gly Val Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu 
        35                  40                  45              


Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys 
    50                  55                  60                  


Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Asn Thr 
65                  70                  75                  80  


Asp Leu Arg Phe Gln Ser Ala Ala Val Gly Ala Leu Gln Glu Ala Ser 
                85                  90                  95      


Glu Ala Tyr Leu Val Gly Leu Leu Glu Asp Thr Asn Leu Cys Ala Ile 
            100                 105                 110         


His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg 
        115                 120                 125             


Arg Ile Arg Gly Glu Arg Ala 
    130                 135 


<210> 19
<211> 843
<212> PRT
<213> Homo sapiens

<400> 19
Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210> 20
<211> 654
<212> PRT
<213> Homo sapiens

<400> 20
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210> 21
<211> 1906
<212> DNA
<213> Homo sapiens

<400> 21
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gtgggtcatt ctgatcaccg aactgaccat gccagccctg ccgatggtcc      720

tccatggctc cctagtgccc tggagaggag gtgtctagtc agagagtagt cctggaaggt      780

ggcctctgtg aggagccacg gggacagcat cctgcagatg gtcctggccc ttgtcccacc      840

gacctgtcta caaggactgt cctcgtggac cctcccctct gcacaggagc tggaccctga      900

agtcccttcc ccaccggcca ggactggagc ccctacccct ctgttggaat ccctgcccac      960

cttcttctgg aagtcggctc tggagacatt tctctcttct tccaaagctg ggaactgcta     1020

tctgttatct gcctgtccag gtctgaaaga taggattgcc caggcagaaa ctgggactga     1080

cctatctcac tctctccctg cttttaccct tagggtgatt ctgggggccc acttgtctgt     1140

aatggtgtgc ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg     1200

ccttccctgt acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc     1260

aacccctgag cacccctatc aaccccctat tgtagtaaac ttggaacctt ggaaatgacc     1320

aggccaagac tcaagcctcc ccagttctac tgacctttgt ccttaggtgt gaggtccagg     1380

gttgctagga aaagaaatca gcagacacag gtgtagacca gagtgtttct taaatggtgt     1440

aattttgtcc tctctgtgtc ctggggaata ctggccatgc ctggagacat atcactcaat     1500

ttctctgagg acacagatag gatggggtgt ctgtgttatt tgtggggtac agagatgaaa     1560

gaggggtggg atccacactg agagagtgga gagtgacatg tgctggacac tgtccatgaa     1620

gcactgagca gaagctggag gcacaacgca ccagacactc acagcaagga tggagctgaa     1680

aacataaccc actctgtcct ggaggcactg ggaagcctag agaaggctgt gagccaagga     1740

gggagggtct tcctttggca tgggatgggg atgaagtaag gagagggact ggaccccctg     1800

gaagctgatt cactatgggg ggaggtgtat tgaagtcctc cagacaaccc tcagatttga     1860

tgatttccta gtagaactca cagaaataaa gagctgttat actgtg                    1906


<210> 22
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 22
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaagcc aggtgatgac tccagccacg acctcatgct gctccgcctg tcagagcctg      300

ccgagctcac ggatgctgtg aaggtcatgg acctgcccac ccaggagcca gcactgggga      360

ccacctgcta cgcctcaggc tggggcagca ttgaaccaga ggagttcttg accccaaaga      420

aacttcagtg tgtggacctc catgttattt ccaatgacgt gtgtgcgcaa gttcaccctc      480

agaaggtgac caagttcatg ctgtgtgctg gacgctggac agggggcaaa agcacctgct      540

cgggtgattc tgggggccca cttgtctgta atggtgtgct tcaaggtatc acgtcatggg      600

gcagtgaacc atgtgccctg cccgaaaggc cttccctgta caccaaggtg gtgcattacc      660

ggaagtggat caaggacacc atcgtggcca acccctgagc acccctatca accccctatt      720

gtagtaaact tggaaccttg gaaatgacca ggccaagact caagcctccc cagttctact      780

gacctttgtc cttaggtgtg aggtccaggg ttgctaggaa aagaaatcag cagacacagg      840

tgtagaccag agtgtttctt aaatggtgta attttgtcct ctctgtgtcc tggggaatac      900

tggccatgcc tggagacata tcactcaatt tctctgagga cacagatagg atggggtgtc      960

tgtgttattt gtggggtaca gagatgaaag aggggtggga tccacactga gagagtggag     1020

agtgacatgt gctggacact gtccatgaag cactgagcag aagctggagg cacaacgcac     1080

cagacactca cagcaaggat ggagctgaaa acataaccca ctctgtcctg gaggcactgg     1140

gaagcctaga gaaggctgtg agccaaggag ggagggtctt cctttggcat gggatgggga     1200

tgaagtaagg agagggactg gaccccctgg aagctgattc actatggggg gaggtgtatt     1260

gaagtcctcc agacaaccct cagatttgat gatttcctag tagaactcac agaaataaag     1320

agctgttata ctgtg                                                      1335


<210> 23
<211> 1464
<212> DNA
<213> Homo sapiens

<400> 23
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gggtgattct gggggcccac ttgtctgtaa tggtgtgctt caaggtatca      720

cgtcatgggg cagtgaacca tgtgccctgc ccgaaaggcc ttccctgtac accaaggtgg      780

tgcattaccg gaagtggatc aaggacacca tcgtggccaa cccctgagca cccctatcaa      840

ccccctattg tagtaaactt ggaaccttgg aaatgaccag gccaagactc aagcctcccc      900

agttctactg acctttgtcc ttaggtgtga ggtccagggt tgctaggaaa agaaatcagc      960

agacacaggt gtagaccaga gtgtttctta aatggtgtaa ttttgtcctc tctgtgtcct     1020

ggggaatact ggccatgcct ggagacatat cactcaattt ctctgaggac acagatagga     1080

tggggtgtct gtgttatttg tggggtacag agatgaaaga ggggtgggat ccacactgag     1140

agagtggaga gtgacatgtg ctggacactg tccatgaagc actgagcaga agctggaggc     1200

acaacgcacc agacactcac agcaaggatg gagctgaaaa cataacccac tctgtcctgg     1260

aggcactggg aagcctagag aaggctgtga gccaaggagg gagggtcttc ctttggcatg     1320

ggatggggat gaagtaagga gagggactgg accccctgga agctgattca ctatgggggg     1380

aggtgtattg aagtcctcca gacaaccctc agatttgatg atttcctagt agaactcaca     1440

gaaataaaga gctgttatac tgtg                                            1464


