                               SEQUENCE LISTING

<110> BAYLOR COLLEGE OF MEDICINE
 
<120> PERIOSTEAL SKELETAL STEM CELLS IN BONE REPAIR

<130> BAYM.P0264WO-1001108708

<140> PCT/US2020/017301
<141> 2020-02-07

<150> 62/802,616
<151> 2019-02-07

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 1319
<212> DNA
<213> Homo sapiens

<400> 1
gctgcagagg attcctgcag aggatcaaga cagcacgtgg acctcgcaca gcctctccca       60

caggtaccat gaaggtctcc gcggcagccc tcgctgtcat cctcattgct actgccctct      120

gcgctcctgc atctgcctcc ccatattcct cggacaccac accctgctgc tttgcctaca      180

ttgcccgccc actgccccgt gcccacatca aggagtattt ctacaccagt ggcaagtgct      240

ccaacccagc agtcgtccac aggtcaagga tgccaaagag agagggacag caagtctggc      300

aggatttcct gtatgactcc cggctgaaca agggcaagct ttgtcacccg aaagaaccgc      360

caagtgtgtg ccaacccaga gaagaaatgg gttcgggagt acatcaactc tttggagatg      420

agctaggatg gagagtcctt gaacctgaac ttacacaaat ttgcctgttt ctgcttgctc      480

ttgtcctagc ttgggaggct tcccctcact atcctacccc acccgctcct tgaagggccc      540

agattctacc acacagcagc agttacaaaa accttcccca ggctggacgt ggtggctcac      600

gcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttgagg tcaggagttc      660

gagaccagcc tggccaacat gatgaaaccc catctctact aaaaatacaa aaaattagcc      720

gggcgtggta gcgggcgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc      780

gtgaacccgg gaggcggagc ttgcagtgag ccgagatcgc gccactgcac tccagcctgg      840

gcgacagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc      900

gggcgtggtg gcccacgcct gtaatcccag ctactcggga ggctaaggca ggaaaattgt      960

ttgaacccag gaggtggagg ctgcagtgag ctgagattgt gccacttcac tccagcctgg     1020

gtgacaaagt gagactccgt cacaacaaca acaacaaaaa gcttccccaa ctaaagccta     1080

gaagagcttc tgaggcgctg ctttgtcaaa aggaagtctc taggttctga gctctggctt     1140

tgccttggct ttgccagggc tctgtgacca ggaaggaagt cagcatgcct ctagaggcaa     1200

ggaggggagg aacactgcac tcttaagctt ccgccgtctc aacccctcac aggagcttac     1260

tggcaaacat gaaaaatcgg cttaccatta aagttctcaa tgcaaccata aaaaaaaaa      1319


<210> 2
<211> 1237
<212> DNA
<213> Homo sapiens

<400> 2
gctgcagagg attcctgcag aggatcaaga cagcacgtgg acctcgcaca gcctctccca       60

caggtaccat gaaggtctcc gcggcagccc tcgctgtcat cctcattgct actgccctct      120

gcgctcctgc atctgcctcc ccatattcct cggacaccac accctgctgc tttgcctaca      180

ttgcccgccc actgccccgt gcccacatca aggagtattt ctacaccagt ggcaagtgct      240

ccaacccagc agtcgtcttt gtcacccgaa agaaccgcca agtgtgtgcc aacccagaga      300

agaaatgggt tcgggagtac atcaactctt tggagatgag ctaggatgga gagtccttga      360

acctgaactt acacaaattt gcctgtttct gcttgctctt gtcctagctt gggaggcttc      420

ccctcactat cctaccccac ccgctccttg aagggcccag attctaccac acagcagcag      480

ttacaaaaac cttccccagg ctggacgtgg tggctcacgc ctgtaatccc agcactttgg      540

gaggccaagg tgggtggatc acttgaggtc aggagttcga gaccagcctg gccaacatga      600

tgaaacccca tctctactaa aaatacaaaa aattagccgg gcgtggtagc gggcgcctgt      660

agtcccagct actcgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt      720

gcagtgagcc gagatcgcgc cactgcactc cagcctgggc gacagagcga gactccgtct      780

caaaaaaaaa aaaaaaaaaa aaaatacaaa aattagccgg gcgtggtggc ccacgcctgt      840

aatcccagct actcgggagg ctaaggcagg aaaattgttt gaacccagga ggtggaggct      900

gcagtgagct gagattgtgc cacttcactc cagcctgggt gacaaagtga gactccgtca      960

caacaacaac aacaaaaagc ttccccaact aaagcctaga agagcttctg aggcgctgct     1020

ttgtcaaaag gaagtctcta ggttctgagc tctggctttg ccttggcttt gccagggctc     1080

tgtgaccagg aaggaagtca gcatgcctct agaggcaagg aggggaggaa cactgcactc     1140

ttaagcttcc gccgtctcaa cccctcacag gagcttactg gcaaacatga aaaatcggct     1200

taccattaaa gttctcaatg caaccataaa aaaaaaa                              1237


<210> 3
<211> 154
<212> PRT
<213> Homo sapiens

<400> 3
Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val His 
    50                  55                  60                  


Arg Ser Arg Met Pro Lys Arg Glu Gly Gln Gln Val Trp Gln Asp Phe 
65                  70                  75                  80  


Leu Tyr Asp Ser Arg Leu Asn Lys Gly Lys Leu Cys His Pro Lys Glu 
                85                  90                  95      


Pro Pro Ser Val Cys Gln Pro Arg Glu Glu Met Gly Ser Gly Val His 
            100                 105                 110         


Gln Leu Phe Gly Asp Glu Leu Gly Trp Arg Val Leu Glu Pro Glu Leu 
        115                 120                 125             


Thr Gln Ile Cys Leu Phe Leu Leu Ala Leu Val Leu Ala Trp Glu Ala 
    130                 135                 140                 


Ser Pro His Tyr Pro Thr Pro Pro Ala Pro 
145                 150                 


<210> 4
<211> 91
<212> PRT
<213> Homo sapiens

<400> 4
Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210> 5
<211> 1686
<212> DNA
<213> Homo sapiens

<400> 5
cagacgctcc ctcagcaagg acagcagagg accagctaag agggagagaa gcaactacag       60

accccccctg aaaacaaccc tcagacgcca catcccctga caagctgcca ggcaggttct      120

cttcctctca catactgacc cacggctcca ccctctctcc cctggaaagg acaccatgag      180

cactgaaagc atgatccggg acgtggagct ggccgaggag gcgctcccca agaagacagg      240

ggggccccag ggctccaggc ggtgcttgtt cctcagcctc ttctccttcc tgatcgtggc      300

aggcgccacc acgctcttct gcctgctgca ctttggagtg atcggccccc agagggaaga      360

gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagat catcttctcg      420

aaccccgagt gacaagcctg tagcccatgt tgtagcaaac cctcaagctg aggggcagct      480

ccagtggctg aaccgccggg ccaatgccct cctggccaat ggcgtggagc tgagagataa      540

ccagctggtg gtgccatcag agggcctgta cctcatctac tcccaggtcc tcttcaaggg      600

ccaaggctgc ccctccaccc atgtgctcct cacccacacc atcagccgca tcgccgtctc      660

ctaccagacc aaggtcaacc tcctctctgc catcaagagc ccctgccaga gggagacccc      720

agagggggct gaggccaagc cctggtatga gcccatctat ctgggagggg tcttccagct      780

ggagaagggt gaccgactca gcgctgagat caatcggccc gactatctcg actttgccga      840

gtctgggcag gtctactttg ggatcattgc cctgtgagga ggacgaacat ccaaccttcc      900

caaacgcctc ccctgcccca atccctttat taccccctcc ttcagacacc ctcaacctct      960

tctggctcaa aaagagaatt gggggcttag ggtcggaacc caagcttaga actttaagca     1020

acaagaccac cacttcgaaa cctgggattc aggaatgtgt ggcctgcaca gtgaagtgct     1080

ggcaaccact aagaattcaa actggggcct ccagaactca ctggggccta cagctttgat     1140

ccctgacatc tggaatctgg agaccaggga gcctttggtt ctggccagaa tgctgcagga     1200

cttgagaaga cctcacctag aaattgacac aagtggacct taggccttcc tctctccaga     1260

tgtttccaga cttccttgag acacggagcc cagccctccc catggagcca gctccctcta     1320

tttatgtttg cacttgtgat tatttattat ttatttatta tttatttatt tacagatgaa     1380

tgtatttatt tgggagaccg gggtatcctg ggggacccaa tgtaggagct gccttggctc     1440

agacatgttt tccgtgaaaa cggagctgaa caataggctg ttcccatgta gccccctggc     1500

ctctgtgcct tcttttgatt atgtttttta aaatatttat ctgattaagt tgtctaaaca     1560

atgctgattt ggtgaccaac tgtcactcat tgctgagcct ctgctcccca ggggagttgt     1620

gtctgtaatc gccctactat tcagtggcga gaaataaagt ttgcttagaa aagaaaaaaa     1680

aaaaaa                                                                1686


<210> 6
<211> 1686
<212> DNA
<213> Homo sapiens

<400> 6
cagacgctcc ctcagcaagg acagcagagg accagctaag agggagagaa gcaactacag       60

accccccctg aaaacaaccc tcagacgcca catcccctga caagctgcca ggcaggttct      120

cttcctctca catactgacc cacggctcca ccctctctcc cctggaaagg acaccatgag      180

cactgaaagc atgatccggg acgtggagct ggccgaggag gcgctcccca agaagacagg      240

ggggccccag ggctccaggc ggtgcttgtt cctcagcctc ttctccttcc tgatcgtggc      300

aggcgccacc acgctcttct gcctgctgca ctttggagtg atcggccccc agagggaaga      360

gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagat catcttctcg      420

aaccccgagt gacaagcctg tagcccatgt tgtagcaaac cctcaagctg aggggcagct      480

ccagtggctg aaccgccggg ccaatgccct cctggccaat ggcgtggagc tgagagataa      540

ccagctggtg gtgccatcag agggcctgta cctcatctac tcccaggtcc tcttcaaggg      600

ccaaggctgc ccctccaccc atgtgctcct cacccacacc atcagccgca tcgccgtctc      660

ctaccagacc aaggtcaacc tcctctctgc catcaagagc ccctgccaga gggagacccc      720

agagggggct gaggccaagc cctggtatga gcccatctat ctgggagggg tcttccagct      780

ggagaagggt gaccgactca gcgctgagat caatcggccc gactatctcg actttgccga      840

gtctgggcag gtctactttg ggatcattgc cctgtgagga ggacgaacat ccaaccttcc      900

caaacgcctc ccctgcccca atccctttat taccccctcc ttcagacacc ctcaacctct      960

tctggctcaa aaagagaatt gggggcttag ggtcggaacc caagcttaga actttaagca     1020

acaagaccac cacttcgaaa cctgggattc aggaatgtgt ggcctgcaca gtgaagtgct     1080

ggcaaccact aagaattcaa actggggcct ccagaactca ctggggccta cagctttgat     1140

ccctgacatc tggaatctgg agaccaggga gcctttggtt ctggccagaa tgctgcagga     1200

cttgagaaga cctcacctag aaattgacac aagtggacct taggccttcc tctctccaga     1260

tgtttccaga cttccttgag acacggagcc cagccctccc catggagcca gctccctcta     1320

tttatgtttg cacttgtgat tatttattat ttatttatta tttatttatt tacagatgaa     1380

tgtatttatt tgggagaccg gggtatcctg ggggacccaa tgtaggagct gccttggctc     1440

agacatgttt tccgtgaaaa cggagctgaa caataggctg ttcccatgta gccccctggc     1500

ctctgtgcct tcttttgatt atgtttttta aaatatttat ctgattaagt tgtctaaaca     1560

atgctgattt ggtgaccaac tgtcactcat tgctgagcct ctgctcccca ggggagttgt     1620

gtctgtaatc gccctactat tcagtggcga gaaataaagt ttgcttagaa aagaaaaaaa     1680

aaaaaa                                                                1686


<210> 7
<211> 3191
<212> DNA
<213> Homo sapiens

<400> 7
ccacaaaggg cacttggccc cagggctagg agagcgaggg gagagcacag ccacccgcct       60

cggcggcccg ggactcggct cgactcgccg gagaatgcgc ccgaggacga cggggcgcca      120

gagccgcggt gctttcaact ggcgagcgcg aatgggggtg cactggagta aggcagagtg      180

atgcgggggg gcaactcgcc tggcaccgag atcgccgccg tgcccttccc tggacccggc      240

gtcgcccagg atggctgccc cgagccatgg gccgcggcgg agctagcgcg gagcgcccga      300

ccctcgaccc ccgagtcccg gagccggccc cgcgcggggc cacgcgtccc tcgggcgctg      360

gttcctaagg aggacgacag caccagcttc tcctttctcc cttcccttcc ctgccccgca      420

ctcctccccc tgctcgctgt tgttgtgtgt cagcacttgg ctggggactt cttgaacttg      480

cagggagaat aacttgcgca ccccactttg cgccggtgcc tttgccccag cggagcctgc      540

ttcgccatct ccgagcccca ccgcccctcc actcctcggc cttgcccgac actgagacgc      600

tgttcccagc gtgaaaagag agactgcgcg gccggcaccc gggagaagga ggaggcaaag      660

aaaaggaacg gacattcggt ccttgcgcca ggtcctttga ccagagtttt tccatgtgga      720

cgctctttca atggacgtgt ccccgcgtgc ttcttagacg gactgcggtc tcctaaaggt      780

cgaccatggt ggccgggacc cgctgtcttc tagcgttgct gcttccccag gtcctcctgg      840

gcggcgcggc tggcctcgtt ccggagctgg gccgcaggaa gttcgcggcg gcgtcgtcgg      900

gccgcccctc atcccagccc tctgacgagg tcctgagcga gttcgagttg cggctgctca      960

gcatgttcgg cctgaaacag agacccaccc ccagcaggga cgccgtggtg cccccctaca     1020

tgctagacct gtatcgcagg cactcaggtc agccgggctc acccgcccca gaccaccggt     1080

tggagagggc agccagccga gccaacactg tgcgcagctt ccaccatgaa gaatctttgg     1140

aagaactacc agaaacgagt gggaaaacaa cccggagatt cttctttaat ttaagttcta     1200

tccccacgga ggagtttatc acctcagcag agcttcaggt tttccgagaa cagatgcaag     1260

atgctttagg aaacaatagc agtttccatc accgaattaa tatttatgaa atcataaaac     1320

ctgcaacagc caactcgaaa ttccccgtga ccagactttt ggacaccagg ttggtgaatc     1380

agaatgcaag caggtgggaa agttttgatg tcacccccgc tgtgatgcgg tggactgcac     1440

agggacacgc caaccatgga ttcgtggtgg aagtggccca cttggaggag aaacaaggtg     1500

tctccaagag acatgttagg ataagcaggt ctttgcacca agatgaacac agctggtcac     1560

agataaggcc attgctagta acttttggcc atgatggaaa agggcatcct ctccacaaaa     1620

gagaaaaacg tcaagccaaa cacaaacagc ggaaacgcct taagtccagc tgtaagagac     1680

accctttgta cgtggacttc agtgacgtgg ggtggaatga ctggattgtg gctcccccgg     1740

ggtatcacgc cttttactgc cacggagaat gcccttttcc tctggctgat catctgaact     1800

ccactaatca tgccattgtt cagacgttgg tcaactctgt taactctaag attcctaagg     1860

catgctgtgt cccgacagaa ctcagtgcta tctcgatgct gtaccttgac gagaatgaaa     1920

aggttgtatt aaagaactat caggacatgg ttgtggaggg ttgtgggtgt cgctagtaca     1980

gcaaaattaa atacataaat atatatatat atatatattt tagaaaaaag aaaaaaacaa     2040

acaaacaaaa aaaccccacc ccagttgaca ctttaatatt tcccaatgaa gactttattt     2100

atggaatgga atggaaaaaa aaacagctat tttgaaaata tatttatatc tacgaaaaga     2160

agttgggaaa acaaatattt taatcagaga attattcctt aaagatttaa aatgtattta     2220

gttgtacatt ttatatgggt tcaaccccag cacatgaagt ataatggtca gatttatttt     2280

gtatttattt actattataa ccacttttta ggaaaaaaat agctaatttg tatttatatg     2340

taatcaaaag aagtatcggg tttgtacata attttccaaa aattgtagtt gttttcagtt     2400

gtgtgtattt aagatgaaaa gtctacatgg aaggttactc tggcaaagtg cttagcacgt     2460

ttgctttttt gcagtgctac tgttgagttc acaagttcaa gtccagaaaa aaaaagtgga     2520

taatccactc tgctgacttt caagattatt atattattca attctcagga atgttgcaga     2580

gtgattgtcc aatccatgag aatttacatc cttattaggt ggaatatttg gataagaacc     2640

agacattgct gatctattat agaaactctc ctcctgcccc ttaatttaca gaaagaataa     2700

agcaggatcc atagaaataa ttaggaaaac gatgaacctg caggaaagtg aatgatggtt     2760

tgttgttctt ctttcctaaa ttagtgatcc cttcaaaggg gctgatctgg ccaaagtatt     2820

caataaaacg taagatttct tcattattga tattgtggtc atatatattt aaaattgata     2880

tctcgtggcc ctcatcaagg gttggaaatt tatttgtgtt ttacctttac ctcatctgag     2940

agctctttat tctccaaaga acccagtttt ctaacttttt gcccaacacg cagcaaaatt     3000

atgcacatcg tgttttctgc ccaccctctg ttctctgacc tatcagcttg cttttctttc     3060

caaggttgtg tgtttgaaca catttctcca aatgttaaac ctatttcaga taataaatat     3120

caaatctctg gcatttcatt ctataaagtc caacctgtaa gagaaaaaaa aaaaaaaaaa     3180

aaaaaaaaaa a                                                          3191


<210> 8
<211> 396
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


