
                                SEQUENCE LISTING

<110> Pittendrigh, Barry Robert
      Board of Trustees of Michigan State University

<120> INHIBITING INSECTICIDE RESISTANCE AND MAKING SUSCEPTIBLE
      INSECTS HYPER-SUSCEPTIBLE TO PESTICIDES
  

<130> 3000.188WO1

<140> PCT/US2020/017351   
<141> 2020-02-07  

<150> US 62/802,305       
<151> 2019-02-07  

<160> 36

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 1
ctttggattg gctcgtattg c                                                21

<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 2
atcgggtagc aacgtattct g                                                21

<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 3
attcttcaac caaatgctgc g                                                21

<210> 4
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 4
ccggatggcc tcctcaa                                                     17

<210> 5
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 5
ggctatactc aacgatacca ctg                                              23

<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 6
ccacattctc aacatcttca acg                                              23

<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 7
cagtagcggt gattccaaaa tg                                               22

<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 8
ggatggagtt gagcagctg                                                   19

<210> 9
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 9
atcaacacca agggcgag                                                    18

<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 10
cgggaacagt tgatcgacg                                                   19

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 11
agatccaaac ccgtccaatc                                                  20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 12
ggagttgtga ttggtgttgc                                                  20

<210> 13
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 13
cctcacatcc acaaatcctc tg                                               22

<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 14
gatacccatc accgtacact c                                                21

<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 15
ccaagaccta ccagaaccaa g                                                21

<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 16
gctccactcc ccaaatctc                                                   19

<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 17
gatgacgaag ccctctataa cg                                               22

<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 18
attatgaggc ccacatcgg                                                   19

<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 19
cctcagcgat gtgatacaga ag                                               22

<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 20
cagcacaaat cggttacgtt c                                                21

<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 21
actatgtgcg tccgaatgg                                                   19

<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 22
gggcgggata gtcattaaag tc                                               22

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 23
gacagaaggt ccatcgagtt c                                                21

<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 24
ttcggctgat gtagtgatgc                                                  20

<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 25
attcttcaac caaatgctgc g                                                21

<210> 26
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 26
ccggatggcc tcctcaa                                                     17

<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 27
cgcttcctct ccattcagta tg                                               22

<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 28
gcacttttcc acgtactgtt tg                                               22

<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 29
gtcatcttcg tataagcaaa ccg                                              23

<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic primer

<400> 30
atcgtctgct tgatctcctt g                                                21

<210> 31
<211> 640
<212> PRT
<213> D. melanogaster

<400> 31
Met Leu Leu Lys Gly Ala Ala Gln Leu Leu Arg Cys Gly Leu Val Ser
 1               5                  10                  15
Pro His Arg Asn Ser Asn Phe Arg Leu Thr Cys Arg Phe Leu Ser Ile
            20                  25                  30
Gln Tyr Gly Asp Ala Lys Ile Leu Thr Pro Ala Val Lys Gln Tyr Val
        35                  40                  45
Glu Lys Cys Val Glu Leu Cys Gln Pro Glu Arg Val His Ile Cys Asp
    50                  55                  60
Gly Thr Glu Val Glu Ser Lys Leu Leu Gln Gly Ile Met Leu Lys Lys
65                  70                  75                  80
Gly Thr Ile Ile Pro Leu Pro Lys Tyr Glu Asn Cys Trp Leu Ala Arg
                85                  90                  95
Thr Asn Pro Ala Asp Val Ala Arg Val Glu Gly Lys Thr Phe Ile Ser
            100                 105                 110
Thr Asp Ser Lys Glu Gln Thr Val Pro Val Thr Glu Lys Ala Thr Pro
        115                 120                 125
Gly Met Leu Gly Asn Trp Ile Ala Glu Lys Asp Met Gln Ala Ala Ile
    130                 135                 140
Lys Glu Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile
145                 150                 155                 160
Pro Phe Ser Met Gly Pro Val Gly Ser Pro Leu Ser Lys Ile Gly Ile
                165                 170                 175
Glu Ile Thr Asp Ser Pro Tyr Val Val Glu Ser Met Lys Ile Met Thr
            180                 185                 190
Arg Ala Gly Asn Pro Val Leu Asn Tyr Leu Gln Ser Gly Asp Gly Gln
        195                 200                 205
Phe Val Lys Cys Leu His Ser Val Gly Thr Pro Lys Ser Gly Val Gln
    210                 215                 220
Ala Met Pro Ser Trp Pro Cys Asp Pro Glu Arg Thr Ile Val Leu His
225                 230                 235                 240
Lys Pro Ala Glu Asn Glu Ile Val Ser Tyr Gly Ser Gly Tyr Gly Gly
                245                 250                 255
Asn Ser Leu Leu Gly Lys Lys Cys Leu Ala Leu Arg Ile Gly Ser Thr
            260                 265                 270
Ile Ala Lys Arg Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly
        275                 280                 285
Ile Thr Asn Pro Gln Gly Lys Lys Ile Tyr Ile Ala Ala Ala Phe Pro
    290                 295                 300
Ser Ala Cys Gly Lys Thr Asn Leu Ala Met Met Thr Pro Thr Leu Pro
305                 310                 315                 320
Gly Tyr Lys Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe
                325                 330                 335
Asp Asn Lys Gly Val Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe
            340                 345                 350
Gly Val Ala Pro Gly Thr Ser Arg Ala Thr Asn Pro Ile Ala Met Asp
        355                 360                 365
Thr Ile Phe Arg Asn Ser Val Phe Thr Asn Val Ala Ser Thr Ser Asp
    370                 375                 380
Gly Gly Val Tyr Trp Glu Gly Met Glu Lys Asp Gln Leu Lys Gly Val
385                 390                 395                 400
Thr Val Thr Asp Trp Leu Gly Lys Leu Trp Ser Gln Glu Ser Gly Lys
                405                 410                 415
Pro Ala Ala His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys
            420                 425                 430
Pro Ile Ile Asp Pro Ala Trp Glu Asp Ser Glu Gly Val Pro Ile Ser
        435                 440                 445
Ala Ile Leu Phe Gly Gly Arg Arg Pro Ser Gly Val Pro Leu Val Tyr
    450                 455                 460
Glu Ala Arg Asp Trp Lys His Gly Val Phe Ile Gly Ala Ala Met Arg
465                 470                 475                 480
Ser Glu Ala Thr Ala Ala Ala Glu Phe Lys Gly Lys Val Ile Met His
                485                 490                 495
Asp Pro Phe Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Asp Tyr
            500                 505                 510
Leu Gly His Trp Leu Ser Met Glu Gln Arg Gly Gln Val Pro Lys Ile
        515                 520                 525
Phe His Val Asn Trp Phe Arg Lys Ser Ser Glu Gly Lys Phe Leu Trp
    530                 535                 540
Pro Gly Phe Gly Glu Asn Ser Arg Val Leu Asp Trp Ile Phe Arg Arg
545                 550                 555                 560
Val Glu Gly Glu Gln Cys Phe Glu Asp Ser Pro Ile Gly Arg Leu Pro
                565                 570                 575
Ser Lys Asn Ser Leu Asn Leu Asp Ser Leu Glu Asn Ile Asp Leu Asp
            580                 585                 590
Gln Leu Phe Asp Leu Pro Lys Asp Phe Trp Glu Gln Glu Val Ala Ala
        595                 600                 605
Ile Glu Arg Arg Tyr Phe Glu Glu Gln Val Gly His His Leu Pro Gly
    610                 615                 620
Ala Val Ala Glu Glu Leu Arg Glu Leu Lys Ala Arg Val Ala Asp Met
625                 630                 635                 640

<210> 32
<211> 640
<212> PRT
<213> D. melanogaster

<400> 32
Met Leu Leu Lys Gly Ala Ala Gln Leu Leu Arg Cys Gly Leu Val Ser
 1               5                  10                  15
Pro His Arg Asn Ser Asn Phe Arg Leu Thr Cys Arg Phe Leu Ser Ile
            20                  25                  30
Gln Tyr Gly Asp Ala Lys Ile Leu Thr Pro Ala Val Lys Gln Tyr Val
        35                  40                  45
Glu Lys Cys Val Glu Leu Cys Gln Pro Glu Arg Val His Ile Cys Asp
    50                  55                  60
Gly Thr Glu Val Glu Ser Lys Leu Leu Gln Gly Ile Met Leu Lys Lys
65                  70                  75                  80
Gly Thr Ile Ile Pro Leu Pro Lys Tyr Glu Asn Cys Trp Leu Ala Arg
                85                  90                  95
Thr Asn Pro Ala Asp Val Ala Arg Val Glu Gly Lys Thr Phe Ile Ser
            100                 105                 110
Thr Asp Ser Lys Glu Gln Thr Val Pro Val Thr Glu Lys Ala Thr Pro
        115                 120                 125
Gly Met Leu Gly Asn Trp Ile Ala Glu Lys Asp Met Gln Ala Ala Ile
    130                 135                 140
Lys Glu Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile
145                 150                 155                 160
Pro Phe Ser Met Gly Pro Val Gly Ser Pro Leu Ser Lys Ile Gly Ile
                165                 170                 175
Glu Ile Thr Asp Ser Pro Tyr Val Val Glu Ser Met Lys Ile Met Thr
            180                 185                 190
Arg Ala Gly Asn Pro Val Leu Asn Tyr Leu Gln Ser Gly Asp Gly Gln
        195                 200                 205
Phe Val Lys Cys Leu His Ser Val Gly Thr Pro Lys Ser Gly Val Gln
    210                 215                 220
Ala Met Pro Ser Trp Pro Cys Asp Pro Glu Arg Thr Ile Val Leu His
225                 230                 235                 240
Lys Pro Ala Glu Asn Glu Ile Val Ser Tyr Gly Ser Gly Tyr Gly Gly
                245                 250                 255
Asn Ser Leu Leu Gly Lys Lys Cys Phe Ala Leu Arg Ile Gly Ser Thr
            260                 265                 270
Ile Ala Lys Gln Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly
        275                 280                 285
Ile Thr Asn Pro Gln Gly Lys Lys Ile Tyr Ile Thr Ala Ala Phe Pro
    290                 295                 300
Ser Ala Cys Gly Lys Thr Asn Leu Ala Met Leu Asn Pro Thr Leu Pro
305                 310                 315                 320
Gly Tyr Lys Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe
                325                 330                 335
Asp Arg Lys Gly Val Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe
            340                 345                 350
Gly Val Ala Pro Gly Thr Ser Met Glu Thr Asn Pro Ile Ala Met Asp
        355                 360                 365
Thr Ile Phe Arg Asn Ser Val Phe Thr Asn Val Ala Ser Thr Ser Asp
    370                 375                 380
Gly Gly Val Tyr Trp Glu Gly Met Glu Lys Asp Gln Leu Lys Gly Val
385                 390                 395                 400
Thr Val Thr Asp Trp Leu Gly Lys Leu Trp Thr Lys Asp Ser Gly Lys
                405                 410                 415
Pro Ala Ala His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys
            420                 425                 430
Pro Ile Ile Asp Glu Ala Trp Glu Asp Pro Glu Gly Val Pro Ile Ser
        435                 440                 445
Ala Met Leu Phe Gly Gly Arg Arg Pro Ala Gly Val Pro Leu Ile Tyr
    450                 455                 460
Glu Ala Arg Asp Trp Thr His Gly Val Phe Ile Gly Ala Ala Met Arg
465                 470                 475                 480
Ser Glu Ala Thr Ala Ala Ala Glu Phe Lys Gly Lys Val Ile Met His
                485                 490                 495
Asp Pro Phe Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Asp Tyr
            500                 505                 510
Val Ala His Trp Leu Ser Met Glu Lys Arg Gly Gln Val Pro Lys Ile
        515                 520                 525
Phe His Val Asn Trp Phe Arg Lys Ser Ala Glu Gly Lys Phe Met Trp
    530                 535                 540
Pro Gly Tyr Gly Glu Asn Ser Arg Val Leu Glu Trp Ile Phe Arg Arg
545                 550                 555                 560
Val Glu Gly Glu Gln Cys Phe Glu Asp Ser Pro Ile Gly Arg Leu Pro
                565                 570                 575
Ser Lys Asn Ser Leu Asn Leu Asp Ser Leu Glu Asn Ile Asp Leu Asp
            580                 585                 590
Gln Leu Phe Asp Leu Pro Lys Asp Phe Trp Glu Gln Glu Val Ala Ala
        595                 600                 605
Ile Glu Arg Arg Tyr Phe Glu Glu Gln Val Gly His His Leu Pro Gly
    610                 615                 620
Ala Val Ala Glu Glu Leu Arg Glu Leu Lys Ala Arg Val Ala Asp Met
625                 630                 635                 640

<210> 33
<211> 641
<212> PRT
<213> D. melanogaster

<400> 33
Met Leu Leu Lys Gly Ala Ala Gln Leu Leu Arg Cys Gly Leu Val Ser
 1               5                  10                  15
Pro His Arg Asn Ser Asn Phe Arg Leu Thr Cys Arg Phe Leu Ser Ile
            20                  25                  30
Gln Tyr Gly Asp Ala Lys Ile Leu Thr Pro Ala Val Lys Gln Tyr Val
        35                  40                  45
Glu Lys Cys Val Glu Leu Cys Gln Pro Glu Arg Val His Ile Cys Asp
    50                  55                  60
Gly Thr Glu Gly Glu Ser Lys Leu Leu Gln Gly Ile Met Leu Lys Lys
65                  70                  75                  80
Gly Thr Ile Ile Pro Leu Pro Lys Tyr Glu Asn Cys Trp Leu Ala Arg
                85                  90                  95
Thr Asn Pro Ala Asp Val Ala Arg Val Glu Gly Lys Thr Phe Ile Ser
            100                 105                 110
Thr Asp Ser Lys Glu Gln Thr Val Pro Val Thr Glu Lys Ala Thr Pro
        115                 120                 125
Gly Met Leu Gly Asn Trp Ile Ala Glu Lys Asp Leu Gln Ala Ala Ile
    130                 135                 140
Lys Glu Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile
145                 150                 155                 160
Pro Phe Ser Met Gly Pro Val Gly Ser Pro Leu Ser Lys Ile Gly Ile
                165                 170                 175
Glu Ile Thr Asp Ser Pro Tyr Val Val Glu Ser Met Lys Ile Met Thr
            180                 185                 190
Arg Ala Gly Asn Pro Val Leu Asn Tyr Leu Gln Ser Gly Asp Gly Gln
        195                 200                 205
Phe Val Lys Cys Leu His Ser Val Gly Thr Pro Lys Ser Gly Val Gln
    210                 215                 220
Ala Met Pro Ser Trp Pro Cys Asp Pro Glu Arg Thr Ile Val Leu His
225                 230                 235                 240
Lys Pro Ala Glu Asn Glu Ile Val Ser Tyr Gly Ser Gly Tyr Gly Gly
                245                 250                 255
Asn Ser Leu Leu Gly Lys Lys Cys Phe Ala Leu Arg Ile Gly Ser Thr
            260                 265                 270
Ile Ala Lys Gln Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly
        275                 280                 285
Ile Thr Asn Pro Gln Gly Lys Lys Ile Tyr Ile Thr Ala Ala Phe Pro
    290                 295                 300
Ser Ala Cys Gly Lys Thr Asn Leu Ala Met Leu Asn Pro Thr Leu Pro
305                 310                 315                 320
Gly Tyr Lys Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe
                325                 330                 335
Asp Lys Lys Gly Val Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe
            340                 345                 350
Gly Val Ala Pro Gly Thr Ser Met Glu Thr Asn Pro Ile Ala Met Asp
        355                 360                 365
Thr Ile Phe Arg Asn Ser Val Phe Thr Asn Val Ala Ser Thr Ser Asp
    370                 375                 380
Gly Gly Val Tyr Trp Glu Gly Met Glu Lys Asp Gln Leu Lys Gly Val
385                 390                 395                 400
Thr Val Thr Asp Trp Leu Gly Lys Leu Trp Thr Lys Asp Ser Gly Lys
                405                 410                 415
Pro Ala Ala His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys
            420                 425                 430
Pro Ile Ile Asp Glu Ala Trp Glu Asp Pro Glu Gly Val Pro Ile Ser
        435                 440                 445
Ala Met Leu Phe Gly Gly Arg Arg Pro Ala Gly Val Pro Leu Ile Tyr
    450                 455                 460
Glu Ala Arg Asp Trp Thr His Gly Val Phe Ile Gly Ala Ala Met Arg
465                 470                 475                 480
Ser Glu Ala Thr Ala Ala Ala Glu Phe Lys Gly Lys Val Ile Met His
                485                 490                 495
Asp Pro Phe Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Asp Tyr
            500                 505                 510
Val Ala His Trp Leu Ser Met Glu Lys Arg Gly Gln Val Pro Lys Ile
        515                 520                 525
Phe His Val Asn Trp Phe Arg Lys Ser Ala Lys Gly Lys Phe Met Trp
    530                 535                 540
Pro Gly Tyr Gly Glu Asn Ser Arg Val Leu Glu Trp Ile Phe Arg Arg
545                 550                 555                 560
Val Glu Gly Glu Gln Cys Phe Glu Asp Ser Pro Ile Gly Arg Leu Pro
                565                 570                 575
Ser Lys Asn Ser Leu Asn Leu Asp Ser Leu Lys Glu Asn Ile Asp Leu
            580                 585                 590
Asp Gln Leu Phe Asp Leu Pro Lys Asp Phe Trp Glu Gln Glu Val Ala
        595                 600                 605
Ala Ile Glu Arg Arg Tyr Phe Glu Glu Gln Val Gly His His Leu Pro
    610                 615                 620
Gly Pro Val Ala Glu Glu Leu Arg Glu Leu Lys Ala Arg Val Ala Asp
625                 630                 635                 640
Met


<210> 34
<211> 772
<212> PRT
<213> D. melanogaster

<400> 34
Met Ile Gln Glu Thr Ser Gly Gly Gln Tyr Ser Thr Leu Lys Val Asp
 1               5                  10                  15
Lys Ser Gln Val Val Pro Val Ala Val Pro Arg Gly Val Arg Lys Val
            20                  25                  30
Val Arg Val Val Arg Lys Lys Lys Leu Ala Pro Gly Ser Gly Ser Val
        35                  40                  45
Asn Glu Ala Ser Glu Ser Asp Gly Ala Gly Ser Gly Thr Thr Thr Ser
    50                  55                  60
Gly Arg Gln Asn Ser Ile Asp Ala Ser Lys Pro Pro Ala Lys Val Ile
65                  70                  75                  80
Lys Asn Lys Arg Gly Ser Leu Gly Gly Gly Gly Ala Ala Pro Pro Ile
                85                  90                  95
Pro Leu Val Thr Lys Lys Lys Asn Lys Arg Arg Ser Ser Ser Glu Glu
            100                 105                 110
Glu Ala Ser Thr Gly Asn Glu Ser Pro Ile Glu Ser Glu Pro Glu Ser
        115                 120                 125
Gly Ser Gly Ser Ser Ser Ser Ser Ala Gly Ser Glu Ser Asp Thr Asp
    130                 135                 140
Ser Glu Thr Thr Ser Ser Ser Ser Ser Thr Thr Glu Ser Ser Asn Ala
145                 150                 155                 160
Asp Arg Lys Ser Lys Ala Asn Gly Lys His Lys Pro Leu Ser Ala Ala
                165                 170                 175
Ala Lys Ala Ala Gln Ser Ala Cys Ser Ser Ser Leu Val Val Ala Ala
            180                 185                 190
Ala Leu Lys Lys Ser Lys Pro Pro Asn Arg Ser Gly Ser Gly Ala Ser
        195                 200                 205
Ile Ala Ser Ala Gly Gly Gly Gly Lys Gln Tyr Lys Asp Pro Ser Met
    210                 215                 220
Lys Gln Leu Ile Gly Lys Leu Asn Asp Leu Trp Pro Glu His Ser Val
225                 230                 235                 240
Ala Leu Ser Ile Pro Lys Glu Val Asp Arg Ser Lys Glu Lys Leu Glu
                245                 250                 255
Gly Ala Trp Glu Thr Thr Gly Arg Asp Gly Ser Lys Ile Thr Thr Val
            260                 265                 270
Val Ala Thr Pro Gly Gln Gly Thr Asp Arg Val Gln Glu Val Ser Tyr
        275                 280                 285
Thr Asp Thr Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Phe Gln
    290                 295                 300
Ala Lys Leu Cys Asp Thr Gly Glu Leu Val Ala Ile Lys Lys Val Leu
305                 310                 315                 320
Gln Asp Arg Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys Leu
                325                 330                 335
Glu His Cys Asn Ile Val Lys Leu Leu Tyr Phe Phe Tyr Ser Ser Gly
            340                 345                 350
Glu Lys Leu Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His
        355                 360                 365
Ser Leu Gly Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu
    370                 375                 380
Asp Pro Glu Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys
385                 390                 395                 400
Gln Leu Leu His Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr
                405                 410                 415
Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala Ile Asn Tyr Thr Thr Lys
            420                 425                 430
Ile Asp Val Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly
        435                 440                 445
Gln Pro Ile Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Val
    450                 455                 460
Ile Lys Val Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn
465                 470                 475                 480
Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln Ile Lys Ser His Pro Trp
                485                 490                 495
Gln Lys Val Phe Arg Ile Arg Thr Pro Thr Glu Ala Ile Asn Leu Val
            500                 505                 510
Ser Leu Leu Leu Glu Tyr Thr Pro Ser Ala Arg Ile Thr Pro Leu Lys
        515                 520                 525
Ala Cys Ala His Pro Phe Phe Asp Glu Leu Arg Met Glu Gly Asn His
    530                 535                 540
Thr Leu Pro Asn Gly Arg Asp Met Pro Pro Leu Phe Asn Phe Thr Glu
545                 550                 555                 560
His Glu Leu Ser Ile Gln Pro Ser Leu Val Pro Gln Leu Leu Pro Lys
                565                 570                 575
His Leu Gln Asn Ala Ser Gly Pro Gly Gly Asn Arg Pro Ser Ala Gly
            580                 585                 590
Gly Ala Ala Ser Ile Ala Ala Ser Gly Ser Thr Ser Val Ser Ser Thr
        595                 600                 605
Gly Ser Gly Ala Ser Val Glu Gly Ser Ala Gln Pro Gln Ser Gln Gly
    610                 615                 620
Thr Ala Ala Ala Ala Gly Ser Gly Ser Gly Gly Ala Thr Ala Gly Thr
625                 630                 635                 640
Gly Gly Ala Ser Ala Gly Gly Pro Gly Ser Gly Asn Asn Ser Ser Ser
                645                 650                 655
Gly Gly Ala Ser Gly Ala Pro Ser Ala Val Ala Ala Gly Gly Ala Asn
            660                 665                 670
Ala Ala Val Ala Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Ala Ala
        675                 680                 685
Thr Ala Ala Ala Thr Ala Thr Gly Ala Ile Gly Ala Thr Asn Ala Gly
    690                 695                 700
Gly Ala Asn Val Thr Gly Ser Gln Ser Asn Ser Ala Leu Asn Ser Ser
705                 710                 715                 720
Gly Ser Gly Gly Ser Gly Asn Gly Glu Ala Ala Gly Ser Gly Ser Gly
                725                 730                 735
Ser Gly Ser Gly Ser Gly Gly Gly Asn Gly Gly Asp Asn Asp Ala Gly
            740                 745                 750
Asp Ser Gly Ala Ile Ala Ser Gly Gly Gly Ala Ala Glu Thr Glu Ala
        755                 760                 765
Ala Ala Ser Gly
    770

<210> 35
<211> 773
<212> PRT
<213> D. melanogaster

<400> 35
Val Ile Gln Glu Thr Ser Gly Gly Gln Tyr Ser Thr Leu Lys Val Asp
 1               5                  10                  15
Lys Ser Gln Val Val Pro Val Ala Val Pro Arg Gly Val Arg Lys Val
            20                  25                  30
Val Arg Val Val Arg Lys Lys Lys Leu Ala Pro Gly Ser Gly Ser Val
        35                  40                  45
Asn Glu Ala Ser Glu Ser Asp Gly Ala Gly Ser Gly Thr Thr Thr Ser
    50                  55                  60
Gly Arg Gln Asn Ser Ile Asp Ala Ser Lys Pro Pro Ala Ala Lys Val
65                  70                  75                  80
Ile Lys Asn Lys Arg Gly Ser Leu Gly Gly Gly Gly Ala Ala Pro Pro
                85                  90                  95
Ile Pro Leu Val Thr Lys Lys Lys Asn Lys Pro Arg Ser Ser Ser Glu
            100                 105                 110
Glu Glu Ala Ser Thr Gly Asn Glu Ser Pro Ile Glu Ser Glu Pro Glu
        115                 120                 125
Ser Gly Ser Gly Ser Ser Ser Ser Ser Ala Gly Ser Asp Ser Asp Ser
    130                 135                 140
Asp Ser Glu Thr Thr Ser Ser Ser Ser Ser Thr Thr Glu Ser Ser Asn
145                 150                 155                 160
Ala Asp Arg Lys Ser Lys Ala Asn Gly Lys His Lys Pro Leu Ser Ala
                165                 170                 175
Ala Thr Lys Ala Ala Gln Ser Ala Cys Ser Ser Ser Leu Val Val Ala
            180                 185                 190
Ala Ala Leu Lys Lys Ser Lys Pro Pro Asn Arg Ser Gly Ser Gly Ala
        195                 200                 205
Ser Ile Ala Ser Ala Gly Gly Gly Gly Lys Gln Tyr Lys Asp Pro Ser
    210                 215                 220
Met Lys Gln Leu Ile Gly Lys Leu Asn Asp Leu Trp Pro Glu His Ser
225                 230                 235                 240
Val Ala Leu Ser Ile Pro Lys Glu Val Asp Arg Ser Lys Glu Lys Leu
                245                 250                 255
Glu Gly Ala Trp Glu Thr Thr Gly Arg Asp Gly Ser Lys Ile Thr Thr
            260                 265                 270
Val Val Ala Thr Pro Gly Gln Gly Thr Asp Arg Val Gln Glu Val Ser
        275                 280                 285
Tyr Thr Asp Thr Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Phe
    290                 295                 300
Gln Ala Lys Leu Cys Asp Thr Gly Glu Leu Val Ala Ile Lys Lys Val
305                 310                 315                 320
Leu Gln Asp Arg Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys
                325                 330                 335
Leu Glu His Cys Asn Ile Val Lys Leu Leu Tyr Phe Phe Tyr Ser Ser
            340                 345                 350
Gly Glu Lys Leu Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile
        355                 360                 365
His Ser Leu Gly Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu
    370                 375                 380
Leu Asp Pro Glu Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala
385                 390                 395                 400
Lys Gln Leu Leu His Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg
                405                 410                 415
Tyr Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala Ile Asn Tyr Thr Thr
            420                 425                 430
Lys Ile Asp Val Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu
        435                 440                 445
Gly Gln Pro Ile Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu
    450                 455                 460
Val Ile Lys Val Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met
465                 470                 475                 480
Asn Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln Ile Lys Ser His Pro
                485                 490                 495
Trp Gln Lys Val Phe Arg Ile Arg Thr Pro Thr Glu Ala Ile Asn Leu
            500                 505                 510
Val Ser Leu Leu Leu Glu Tyr Thr Pro Ser Ala Arg Ile Thr Pro Leu
        515                 520                 525
Lys Ala Cys Ala His Pro Phe Phe Asp Glu Leu Arg Met Glu Gly Asn
    530                 535                 540
His Thr Leu Pro Asn Gly Arg Asp Met Pro Pro Leu Phe Asn Phe Thr
545                 550                 555                 560
Glu His Glu Leu Ser Ile Gln Pro Ser Leu Val Pro Gln Leu Leu Pro
                565                 570                 575
Lys His Leu Gln Asn Ala Ser Gly Pro Gly Gly Asn Arg Pro Ser Ala
            580                 585                 590
Gly Gly Ala Ala Ser Ile Ala Ala Ser Gly Ser Thr Ser Val Ser Ser
        595                 600                 605
Thr Gly Ser Gly Ala Ser Val Glu Gly Ser Ala Gln Pro Gln Ser Gln
    610                 615                 620
Gly Thr Ala Ala Ala Ala Gly Ser Gly Ser Gly Gly Ala Thr Ala Gly
625                 630                 635                 640
Thr Gly Gly Ala Ser Ala Gly Gly Pro Gly Ser Gly Asn Asn Ser Ser
                645                 650                 655
Ser Gly Gly Ala Ser Gly Ala Pro Ser Ala Val Ala Ala Gly Gly Ala
            660                 665                 670
Asn Ala Ala Val Ala Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Ala
        675                 680                 685
Ala Thr Ala Ala Ala Thr Ala Thr Gly Ala Ile Gly Ala Thr Asn Ala
    690                 695                 700
Gly Gly Ala Asn Val Thr Gly Ser Gln Ser Asn Ser Ala Leu Asn Ser
705                 710                 715                 720
Ser Gly Ser Gly Gly Ser Gly Asn Gly Glu Ala Ala Gly Ser Gly Ser
                725                 730                 735
Gly Ser Gly Ser Gly Ser Gly Gly Gly Asn Gly Gly Asp Asn Asp Ala
            740                 745                 750
Gly Asp Ser Gly Ala Ile Ala Ser Gly Gly Gly Ala Ala Glu Thr Glu
        755                 760                 765
Ala Ala Ala Ser Gly
    770

<210> 36
<211> 772
<212> PRT
<213> D. melanogaster

<400> 36
Val Ile Gln Glu Thr Ser Gly Gly Gln Tyr Ser Thr Leu Lys Val Asp
 1               5                  10                  15
Lys Ser Gln Val Val Pro Val Ala Val Pro Arg Gly Val Arg Lys Val
            20                  25                  30
Val Arg Val Val Arg Lys Lys Lys Leu Ala Pro Gly Ser Gly Ser Val
        35                  40                  45
Asn Glu Ala Ser Glu Ser Asp Gly Ala Gly Ser Gly Thr Thr Thr Ser
    50                  55                  60
Gly Arg Gln Asn Ser Ile Asp Ala Ser Lys Pro Pro Ala Lys Val Ile
65                  70                  75                  80
Lys Asn Lys Arg Gly Ser Leu Gly Gly Gly Gly Ala Ala Pro Pro Ile
                85                  90                  95
Pro Leu Val Thr Lys Lys Lys Asn Lys Arg Arg Ser Ser Ser Glu Glu
            100                 105                 110
Glu Ala Ser Thr Gly Asn Glu Ser Pro Ile Glu Ser Glu Pro Glu Ser
        115                 120                 125
Gly Ser Gly Ser Ser Ser Ser Ser Ala Gly Ser Glu Ser Asp Thr Asp
    130                 135                 140
Ser Glu Thr Thr Ser Ser Ser Ser Ser Thr Thr Glu Ser Ser Asn Ala
145                 150                 155                 160
Asp Arg Lys Ser Lys Ala Asn Gly Lys His Lys Pro Leu Ser Ala Ala
                165                 170                 175
Ala Lys Ala Ala Gln Ser Ala Cys Ser Ser Ser Leu Val Val Ala Ala
            180                 185                 190
Ala Leu Lys Lys Ser Lys Pro Pro Asn Arg Ser Gly Ser Gly Ala Ser
        195                 200                 205
Ile Ala Ser Ala Gly Gly Gly Gly Lys Gln Tyr Lys Asp Pro Ser Met
    210                 215                 220
Lys Gln Leu Ile Gly Lys Leu Asn Asp Leu Trp Pro Glu His Ser Val
225                 230                 235                 240
Ala Leu Ser Ile Pro Lys Glu Val Asp Arg Ser Lys Glu Lys Leu Glu
                245                 250                 255
Gly Ala Trp Glu Thr Thr Gly Arg Asp Gly Ser Lys Ile Thr Thr Val
            260                 265                 270
Val Ala Thr Pro Gly Gln Gly Thr Asp Arg Val Gln Glu Val Ser Tyr
        275                 280                 285
Thr Asp Thr Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Phe Gln
    290                 295                 300
Ala Lys Leu Cys Asp Thr Gly Glu Leu Val Ala Ile Lys Lys Val Leu
305                 310                 315                 320
Gln Asp Arg Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys Leu
                325                 330                 335
Glu His Cys Asn Ile Val Lys Leu Leu Tyr Phe Phe Tyr Ser Ser Gly
            340                 345                 350
Glu Lys Leu Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His
        355                 360                 365
Ser Leu Gly Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu
    370                 375                 380
Asp Pro Glu Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys
385                 390                 395                 400
Gln Leu Leu His Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr
                405                 410                 415
Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala Ile Asn Tyr Thr Thr Lys
            420                 425                 430
Ile Asp Val Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly
        435                 440                 445
Gln Pro Ile Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Val
    450                 455                 460
Ile Lys Val Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn
465                 470                 475                 480
Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln Ile Lys Ser His Pro Trp
                485                 490                 495
Gln Lys Val Phe Arg Ile Arg Thr Pro Thr Glu Ala Ile Asn Leu Val
            500                 505                 510
Ser Leu Leu Leu Glu Tyr Thr Pro Ser Ala Arg Ile Thr Pro Leu Lys
        515                 520                 525
Ala Cys Ala His Pro Phe Phe Asp Glu Leu Arg Met Glu Gly Asn His
    530                 535                 540
Thr Leu Pro Asn Gly Arg Asp Met Pro Pro Leu Phe Asn Phe Thr Glu
545                 550                 555                 560
His Glu Leu Ser Ile Gln Pro Ser Leu Val Pro Gln Leu Leu Pro Lys
                565                 570                 575
His Leu Gln Asn Ala Ser Gly Pro Gly Gly Asn Arg Pro Ser Ala Gly
            580                 585                 590
Gly Ala Ala Ser Ile Ala Ala Ser Gly Ser Ala Ser Val Ser Ser Thr
        595                 600                 605
Gly Ser Gly Ala Ser Val Glu Gly Ser Ala Gln Pro Gln Ser Gln Gly
    610                 615                 620
Thr Ala Ala Ala Ala Gly Ser Gly Ser Gly Gly Ala Thr Ala Gly Thr
625                 630                 635                 640
Gly Gly Ala Ser Ala Gly Gly Pro Gly Ser Gly Asn Asn Ser Ser Ser
                645                 650                 655
Gly Gly Ala Ser Gly Ala Pro Ser Ala Val Ala Ala Gly Gly Ala Asn
            660                 665                 670
Ala Ala Val Ala Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Ala Ala
        675                 680                 685
Thr Ala Ala Ala Thr Ala Thr Gly Ala Ile Gly Ala Thr Asn Ala Gly
    690                 695                 700
Gly Ala Asn Val Thr Gly Ser Gln Ser Asn Ser Ala Leu Asn Ser Ser
705                 710                 715                 720
Gly Ser Gly Gly Ser Gly Asn Gly Glu Ala Ala Gly Ser Gly Ser Gly
                725                 730                 735
Ser Gly Ser Gly Ser Gly Gly Gly Asn Gly Gly Asp Asn Asp Ala Gly
            740                 745                 750
Asp Ser Gly Ala Ile Ala Ser Gly Gly Gly Ala Ala Glu Thr Glu Ala
        755                 760                 765
Ala Ala Ser Gly
    770
