                         SEQUENCE LISTING

<110>  Qualus Research SpA
 
<120>  METHOD FOR PRODUCING ARTIFICIAL HISTONE H1 SEQUENCES FOR THE 
       ANALYSIS, DIAGNOSIS, TREATMENT, AND/OR PREVENTION OF SENESCENCE, 
       AND/OR AGE RELATED HEALTH CONDITIONS AND USES THEREOF

<130>  ALBA2019-085.FV.P.US

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  H. sapiens

<400>  1

Lys Tyr Ser Asp Met Ile Val Ala Ala Ile Gln Ala Glu 
1               5                   10              


<210>  2
<211>  12
<212>  PRT
<213>  H. sapiens

<400>  2

Arg Gln Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr 
1               5                   10          


<210>  3
<211>  16
<212>  PRT
<213>  H. sapiens

<400>  3

Asn Ala Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr 
1               5                   10                  15      


<210>  4
<211>  13
<212>  PRT
<213>  H. sapiens

<400>  4

Lys Tyr Ser Gln Leu Val Val Glu Thr Ile Arg Arg Leu 
1               5                   10              


<210>  5
<211>  12
<212>  PRT
<213>  H. sapiens

<400>  5

Leu Ala Lys Ile Tyr Thr Glu Ala Lys Lys Val Pro 
1               5                   10          


<210>  6
<211>  16
<212>  PRT
<213>  H. sapiens

<400>  6

Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Lys Ala Leu Val Gln Asn 
1               5                   10                  15      


<210>  7
<211>  232
<212>  PRT
<213>  Caenorhabditis elegans

<400>  7

Met Thr Thr Ser Leu Ile His Met Ala Asn His Leu Asp Ala Ser Thr 
1               5                   10                  15      


Glu Glu Ile Ser Leu Asn Tyr Val Leu Leu Gly His Pro His His Glu 
            20                  25                  30          


Arg Ala Gln His His Pro Ser Tyr Met Asp Met Ile Lys Gly Ala Ile 
        35                  40                  45              


Gln Ala Ile Asp Asn Gly Thr Gly Ser Ser Lys Ala Ala Ile Leu Lys 
    50                  55                  60                  


Tyr Ile Ala Gln Asn Tyr His Val Gly Glu Asn Leu Pro Lys Val Asn 
65                  70                  75                  80  


Asn His Leu Arg Ser Val Leu Lys Lys Ala Val Asp Ser Gly Asp Ile 
                85                  90                  95      


Glu Gln Thr Arg Gly His Gly Ala Thr Gly Ser Phe Arg Met Gly Lys 
            100                 105                 110         


Glu Cys Glu Lys Asn Leu Gln Val Gly Ile Pro Val Gln Thr Lys Pro 
        115                 120                 125             


Met Leu Met Leu Lys Glu Val Arg Gln Lys Leu Glu Asn Ile Ser Lys 
    130                 135                 140                 


Ala Glu Lys Thr Lys Pro Ser Thr Ser Ser Met Ser Thr Asn Lys Lys 
145                 150                 155                 160 


Gly Lys Pro Ile Ser Thr Met Lys Lys Arg Gly Val Met Ser Lys Lys 
                165                 170                 175     


Arg Ser Ser Lys Asn Lys Met Ala Pro Lys Ala Lys Ser His Gly Leu 
            180                 185                 190         


Lys Lys Lys Gly Pro Ala Thr Lys Ser Ser Gly Leu Val His Lys Ala 
        195                 200                 205             


Ala Gly Ala Lys Asn Glu Ala Ala Pro Thr Thr Lys Met Glu Leu Arg 
    210                 215                 220                 


Thr Gly Thr Arg Lys Ser Tyr Cys 
225                 230         


<210>  8
<211>  232
<212>  PRT
<213>  C. elegans

<400>  8

Met Thr Thr Ser Leu Ile His Met Ala Asn His Leu Asp Ala Ser Thr 
1               5                   10                  15      


Glu Glu Ile Ser Leu Asn Tyr Val Leu Leu Gly His Pro His His Glu 
            20                  25                  30          


Arg Ala Gln His His Pro Pro Tyr Met Asp Met Ile Lys Gly Ala Ile 
        35                  40                  45              


Gln Ala Ile Asp Asn Gly Thr Gly Ser Ser Arg Ala Ala Ile Leu Lys 
    50                  55                  60                  


Tyr Ile Ala Gln Asn Tyr His Val Gly Glu Asn Leu Pro Lys Val Asn 
65                  70                  75                  80  


Asn His Leu Arg Ser Val Leu Lys Arg Ala Val Asp Ser Gly Asp Ile 
                85                  90                  95      


Glu Gln Thr Arg Gly His Gly Ala Thr Gly Ser Phe Arg Met Gly Lys 
            100                 105                 110         


Glu Cys Glu Lys Asn Leu Gln Val Gly Ile Pro Val Gln Thr Lys Pro 
        115                 120                 125             


Met Leu Met Leu Lys Glu Val Arg Gln Lys Leu Glu Asn Ile Ser Lys 
    130                 135                 140                 


Ala Glu Lys Thr Lys Pro Ser Thr Ser Ser Met Ser Thr Asn Lys Lys 
145                 150                 155                 160 


Gly Lys Pro Ile Ser Thr Met Lys Lys Arg Gly Val Met Ser Lys Lys 
                165                 170                 175     


Arg Ser Ser Lys Asn Lys Met Ala Pro Lys Ala Lys Ser His Gly Leu 
            180                 185                 190         


Lys Lys Lys Gly Pro Ala Thr Lys Ser Ser Gly Leu Val His Lys Ala 
        195                 200                 205             


Ala Gly Ala Lys Asn Glu Ala Ala Pro Thr Thr Lys Met Glu Leu Arg 
    210                 215                 220                 


Thr Gly Thr Arg Lys Ser Tyr Cys 
225                 230         


<210>  9
<211>  194
<212>  PRT
<213>  Mus musculus

<400>  9

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Val Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Thr Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys 
            180                 185                 190         


Lys Lys 
        


<210>  10
<211>  194
<212>  PRT
<213>  M. musculus

<400>  10

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Arg Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Val Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Thr Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys 
            180                 185                 190         


Lys Lys 
        


<210>  11
<211>  194
<212>  PRT
<213>  M. musculus

<400>  11

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ala Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asn Ser Gln Ile Lys Leu Ser Ile Lys Arg Arg Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Val Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Thr Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys 
            180                 185                 190         


Lys Lys 
        


<210>  12
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys 
            180                 185                 190         


Lys Lys 
        


<210>  13
<211>  194
<212>  PRT
<213>  H. sapiens

<400>  13

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Arg Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys 
            180                 185                 190         


Lys Lys 
        


<210>  14
<211>  213
<212>  PRT
<213>  H. sapiens

<400>  14

Met Ser Val Glu Leu Glu Glu Ala Leu Pro Val Thr Thr Ala Glu Gly 
1               5                   10                  15      


Met Ala Lys Lys Val Thr Lys Ala Gly Gly Ser Ala Ala Leu Ser Pro 
            20                  25                  30          


Ser Lys Lys Arg Lys Asn Ser Lys Lys Lys Asn Gln Pro Gly Lys Tyr 
        35                  40                  45              


Ser Gln Leu Val Val Glu Thr Ile Arg Arg Leu Gly Glu Arg Asn Gly 
    50                  55                  60                  


Ser Ser Leu Ala Lys Ile Tyr Thr Glu Ala Lys Lys Val Pro Trp Phe 
65                  70                  75                  80  


Asp Gln Gln Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Lys Ala Leu 
                85                  90                  95      


Val Gln Asn Asp Thr Leu Leu Gln Val Lys Gly Thr Gly Ala Asn Gly 
            100                 105                 110         


Ser Phe Lys Leu Asn Arg Lys Lys Leu Glu Gly Gly Gly Glu Arg Arg 
        115                 120                 125             


Gly Ala Pro Ala Ala Ala Thr Ala Pro Ala Pro Thr Ala His Lys Ala 
    130                 135                 140                 


Lys Lys Ala Ala Pro Gly Ala Ala Gly Ser Arg Arg Ala Asp Lys Lys 
145                 150                 155                 160 


Pro Ala Arg Gly Gln Lys Pro Glu Gln Arg Ser His Lys Lys Gly Ala 
                165                 170                 175     


Gly Ala Lys Lys Asp Lys Gly Gly Lys Ala Lys Lys Thr Ala Ala Ala 
            180                 185                 190         


Gly Gly Lys Lys Val Lys Lys Ala Ala Lys Pro Ser Val Pro Lys Val 
        195                 200                 205             


Pro Lys Gly Arg Lys 
    210             


<210>  15
<211>  213
<212>  PRT
<213>  H. sapiens

<400>  15

Met Ser Val Glu Leu Glu Glu Ala Leu Pro Val Thr Thr Ala Glu Gly 
1               5                   10                  15      


Met Ala Lys Lys Val Thr Lys Ala Gly Gly Ser Ala Ala Leu Ser Pro 
            20                  25                  30          


Ser Lys Lys Arg Lys Asn Ser Lys Lys Lys Asn Gln Pro Gly Lys Tyr 
        35                  40                  45              


Ser Gln Leu Val Val Glu Thr Ile Arg Arg Leu Gly Glu Arg Asn Gly 
    50                  55                  60                  


Ser Ser Leu Ala Lys Ile Tyr Thr Glu Ala Lys Lys Val Pro Trp Phe 
65                  70                  75                  80  


Asp Gln Gln Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Lys Arg Arg 
                85                  90                  95      


Val Gln Asn Asp Thr Leu Leu Gln Val Lys Gly Thr Gly Ala Asn Gly 
            100                 105                 110         


Ser Phe Lys Leu Asn Arg Lys Lys Leu Glu Gly Gly Gly Glu Arg Arg 
        115                 120                 125             


Gly Ala Pro Ala Ala Ala Thr Ala Pro Ala Pro Thr Ala His Lys Ala 
    130                 135                 140                 


Lys Lys Ala Ala Pro Gly Ala Ala Gly Ser Arg Arg Ala Asp Lys Lys 
145                 150                 155                 160 


Pro Ala Arg Gly Gln Lys Pro Glu Gln Arg Ser His Lys Lys Gly Ala 
                165                 170                 175     


Gly Ala Lys Lys Asp Lys Gly Gly Lys Ala Lys Lys Thr Ala Ala Ala 
            180                 185                 190         


Gly Gly Lys Lys Val Lys Lys Ala Ala Lys Pro Ser Val Pro Lys Val 
        195                 200                 205             


Pro Lys Gly Arg Lys 
    210             


<210>  16
<211>  194
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Thr Glu Asn Ser Thr Ser Thr Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ala Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Ile Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys 
            180                 185                 190         


Lys Lys 
        


<210>  17
<211>  194
<212>  PRT
<213>  R. norvegicus

<400>  17

Met Thr Glu Asn Ser Thr Ser Thr Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ala Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Arg Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Ile Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys 
            180                 185                 190         


Lys Lys 
        


<210>  18
<211>  192
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Ser Val Glu Leu Glu Glu Ala Leu Pro Pro Thr Ser Ala Asp Gly 
1               5                   10                  15      


Thr Ala Arg Lys Thr Ala Lys Ala Ser Gly Ser Ala Ala Pro Thr Gln 
            20                  25                  30          


Pro Lys Arg Arg Lys Asn Arg Lys Lys Asn Gln Pro Gly Lys Tyr Ser 
        35                  40                  45              


Gln Leu Val Val Glu Thr Ile Arg Lys Leu Gly Glu Arg Gly Gly Ser 
    50                  55                  60                  


Ser Leu Ala Arg Ile Tyr Ala Glu Ala Arg Lys Val Ala Trp Phe Asp 
65                  70                  75                  80  


Gln Gln Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Arg Ala Leu Val 
                85                  90                  95      


Gln Asn Asp Thr Leu Leu Gln Val Lys Gly Thr Gly Ala Asn Gly Ser 
            100                 105                 110         


Phe Lys Leu Asn Arg Lys Lys Leu Glu Gly Ser Ala Glu Lys Arg Gly 
        115                 120                 125             


Ala Ser Ala Ala Ser Ser Pro Ala Pro Lys Ala Arg Thr Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Asp Arg Thr Pro Ala Arg Pro Gln Pro Glu Arg Arg Ala 
145                 150                 155                 160 


Gln Lys Ser Lys Lys Ala Ala Ala Ala Ala Ala Ser Thr Lys Lys Val 
                165                 170                 175     


Lys Lys Ala Ala Lys Pro Ser Val Pro Lys Val Pro Lys Gly Arg Lys 
            180                 185                 190         


<210>  19
<211>  192
<212>  PRT
<213>  R. norvegicus

<400>  19

Met Ser Val Glu Leu Glu Glu Ala Leu Pro Pro Thr Ser Ala Asp Gly 
1               5                   10                  15      


Thr Ala Arg Lys Thr Ala Lys Ala Ser Gly Ser Ala Ala Pro Thr Gln 
            20                  25                  30          


Pro Lys Arg Arg Lys Asn Arg Lys Lys Asn Gln Pro Gly Lys Tyr Ser 
        35                  40                  45              


Gln Leu Val Val Glu Thr Ile Arg Lys Leu Gly Glu Arg Gly Gly Ser 
    50                  55                  60                  


Ser Leu Ala Arg Ile Tyr Ala Glu Ala Arg Lys Val Ala Trp Phe Asp 
65                  70                  75                  80  


Gln Gln Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Arg Arg Arg Val 
                85                  90                  95      


Gln Asn Asp Thr Leu Leu Gln Val Lys Gly Thr Gly Ala Asn Gly Ser 
            100                 105                 110         


Phe Lys Leu Asn Arg Lys Lys Leu Glu Gly Ser Ala Glu Lys Arg Gly 
        115                 120                 125             


Ala Ser Ala Ala Ser Ser Pro Ala Pro Lys Ala Arg Thr Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Asp Arg Thr Pro Ala Arg Pro Gln Pro Glu Arg Arg Ala 
145                 150                 155                 160 


Gln Lys Ser Lys Lys Ala Ala Ala Ala Ala Ala Ser Thr Lys Lys Val 
                165                 170                 175     


Lys Lys Ala Ala Lys Pro Ser Val Pro Lys Val Pro Lys Gly Arg Lys 
            180                 185                 190         


<210>  20
<211>  194
<212>  PRT
<213>  Nothobranchius furzeri

<400>  20

Met Ala Glu Thr Ser Gly Ala Pro Ala Lys Ala Lys Lys Ala Ser Lys 
1               5                   10                  15      


Pro Lys Lys Pro Ala Ser His Pro Lys Tyr Ser Asp Met Ile Lys Ala 
            20                  25                  30          


Ala Ile Val His Asp Ala Ser Arg Ser Gly Ala Ser Arg Gln Ser Ile 
        35                  40                  45              


Gln Lys Tyr Val Arg Lys Thr Tyr Lys Val Gly Asp Asn Ala Asp Val 
    50                  55                  60                  


Gln Ile Lys Met Ala Leu Lys Arg Leu Val Ala Ser Gly Met Leu Arg 
65                  70                  75                  80  


His Thr Lys Gly Ile Gly Ala Ser Gly Ser Phe Arg Leu Thr Lys Pro 
                85                  90                  95      


Glu Asp Ser Lys Lys Pro Ala Lys Ala Ala Ala Ser Ala Lys Pro Lys 
            100                 105                 110         


Lys Val Ala Lys Pro Lys Pro Lys Lys Ala Ala Lys Pro Lys Lys Val 
        115                 120                 125             


Pro Lys Thr Pro Glu Lys Pro Lys Lys Ala Ala Ala Lys Lys Val Lys 
    130                 135                 140                 


Lys Val Ala Lys Lys Ala Thr Pro Ala Lys Ala Lys Lys Ala Pro Ala 
145                 150                 155                 160 


Lys Lys Ser Lys Ala Ala Lys Pro Lys Ala Lys Pro Ala Lys Lys Ala 
                165                 170                 175     


Ala Lys Pro Lys Ala Lys Thr Pro Lys Lys Ala Ala Lys Ser Ala Lys 
            180                 185                 190         


Lys Lys 
        


<210>  21
<211>  194
<212>  PRT
<213>  N. furzeri

<400>  21

Met Ala Glu Thr Ser Gly Ala Pro Ala Lys Ala Lys Lys Ala Ser Lys 
1               5                   10                  15      


Pro Lys Lys Pro Ala Ser His Pro Lys Tyr Ser Asp Met Ile Lys Ala 
            20                  25                  30          


Ala Ile Val His Asp Ala Ser Arg Ser Gly Ala Ser Arg Gln Ala Ile 
        35                  40                  45              


Gln Lys Tyr Val Arg Lys Thr Tyr Lys Val Gly Asp Asn Ala Asn Val 
    50                  55                  60                  


Gln Ile Lys Met Ala Leu Lys Arg Arg Val Ala Ser Gly Met Leu Arg 
65                  70                  75                  80  


His Thr Lys Gly Ile Gly Ala Ser Gly Ser Phe Arg Leu Thr Lys Pro 
                85                  90                  95      


Glu Asp Ser Lys Lys Pro Ala Lys Ala Ala Ala Ser Ala Lys Pro Lys 
            100                 105                 110         


Lys Val Ala Lys Pro Lys Pro Lys Lys Ala Ala Lys Pro Lys Lys Val 
        115                 120                 125             


Pro Lys Thr Pro Glu Lys Pro Lys Lys Ala Ala Ala Lys Lys Val Lys 
    130                 135                 140                 


Lys Val Ala Lys Lys Ala Thr Pro Ala Lys Ala Lys Lys Ala Pro Ala 
145                 150                 155                 160 


Lys Lys Ser Lys Ala Ala Lys Pro Lys Ala Lys Pro Ala Lys Lys Ala 
                165                 170                 175     


Ala Lys Pro Lys Ala Lys Thr Pro Lys Lys Ala Ala Lys Ser Ala Lys 
            180                 185                 190         


Lys Lys 
        


<210>  22
<211>  256
<212>  PRT
<213>  Drosophila melanogaster

<400>  22

Met Ser Asp Ser Ala Val Ala Thr Ser Ala Ser Pro Val Ala Ala Pro 
1               5                   10                  15      


Pro Ala Thr Val Glu Lys Lys Val Val Gln Lys Lys Ala Ser Gly Ser 
            20                  25                  30          


Ala Gly Thr Lys Ala Lys Lys Ala Ser Ala Thr Pro Ser His Pro Pro 
        35                  40                  45              


Thr Gln Gln Met Val Asp Ala Ser Ile Lys Asn Leu Lys Glu Arg Gly 
    50                  55                  60                  


Gly Ser Ser Leu Leu Ala Ile Lys Lys Tyr Ile Thr Ala Thr Tyr Lys 
65                  70                  75                  80  


Cys Asp Ala Gln Lys Leu Ala Pro Phe Ile Lys Lys Tyr Leu Lys Ser 
                85                  90                  95      


Ala Val Val Asn Gly Lys Leu Ile Gln Thr Lys Gly Lys Gly Ala Ser 
            100                 105                 110         


Gly Ser Phe Lys Leu Ser Ala Ser Ala Lys Lys Glu Lys Asp Pro Lys 
        115                 120                 125             


Ala Lys Ser Lys Val Leu Ser Ala Glu Lys Lys Val Gln Ser Lys Lys 
    130                 135                 140                 


Val Ala Ser Lys Lys Ile Gly Val Ser Ser Lys Lys Thr Ala Val Gly 
145                 150                 155                 160 


Ala Ala Asp Lys Lys Pro Lys Ala Lys Lys Ala Val Ala Thr Lys Lys 
                165                 170                 175     


Thr Ala Glu Asn Lys Lys Thr Glu Lys Ala Lys Ala Lys Asp Ala Lys 
            180                 185                 190         


Lys Thr Gly Ile Ile Lys Ser Lys Pro Ala Ala Thr Lys Ala Lys Val 
        195                 200                 205             


Thr Ala Ala Lys Pro Lys Ala Val Val Ala Lys Ala Ser Lys Ala Lys 
    210                 215                 220                 


Pro Ala Val Ser Ala Lys Pro Lys Lys Thr Val Lys Lys Ala Ser Val 
225                 230                 235                 240 


Ser Ala Thr Ala Lys Lys Pro Lys Ala Lys Thr Thr Ala Ala Lys Lys 
                245                 250                 255     


<210>  23
<211>  256
<212>  PRT
<213>  D. melanogaster

<400>  23

Met Ser Asp Ser Ala Val Ala Thr Ser Ala Ser Pro Val Ala Ala Pro 
1               5                   10                  15      


Pro Ala Thr Val Glu Lys Lys Val Val Gln Lys Lys Ala Ser Gly Ser 
            20                  25                  30          


Ala Gly Thr Lys Ala Lys Lys Ala Ser Ala Thr Pro Ser His Pro Pro 
        35                  40                  45              


Thr Gln Gln Met Val Asp Ala Ser Ile Lys Asn Leu Lys Glu Arg Gly 
    50                  55                  60                  


Gly Ser Ser Arg Leu Ala Ile Lys Lys Tyr Ile Thr Ala Thr Tyr Lys 
65                  70                  75                  80  


Cys Asp Ala Gln Met Leu Ala Pro Phe Ile Lys Lys Tyr Leu Lys Arg 
                85                  90                  95      


Ala Val Val Asn Gly Lys Leu Ile Gln Thr Lys Gly Lys Gly Ala Ser 
            100                 105                 110         


Gly Ser Phe Lys Leu Ser Ala Ser Ala Lys Lys Glu Lys Asp Pro Lys 
        115                 120                 125             


Ala Lys Ser Lys Val Leu Ser Ala Glu Lys Lys Val Gln Ser Lys Lys 
    130                 135                 140                 


Val Ala Ser Lys Lys Ile Gly Val Ser Ser Lys Lys Thr Ala Val Gly 
145                 150                 155                 160 


Ala Ala Asp Lys Lys Pro Lys Ala Lys Lys Ala Val Ala Thr Lys Lys 
                165                 170                 175     


Thr Ala Glu Asn Lys Lys Thr Glu Lys Ala Lys Ala Lys Asp Ala Lys 
            180                 185                 190         


Lys Thr Gly Ile Ile Lys Ser Lys Pro Ala Ala Thr Lys Ala Lys Val 
        195                 200                 205             


Thr Ala Ala Lys Pro Lys Ala Val Val Ala Lys Ala Ser Lys Ala Lys 
    210                 215                 220                 


Pro Ala Val Ser Ala Lys Pro Lys Lys Thr Val Lys Lys Ala Ser Val 
225                 230                 235                 240 


Ser Ala Thr Ala Lys Lys Pro Lys Ala Lys Thr Thr Ala Ala Lys Lys 
                245                 250                 255     


<210>  24
<211>  167
<212>  PRT
<213>  Arabidopsis thaliana

<400>  24

Met Ala Glu Asp Lys Ile Leu Lys Lys Thr Pro Ala Ala Lys Lys Pro 
1               5                   10                  15      


Arg Lys Pro Lys Thr Thr Thr His Pro Pro Tyr Phe Gln Met Ile Lys 
            20                  25                  30          


Glu Ala Leu Met Val Leu Lys Glu Lys Asn Gly Ser Ser Pro Tyr Ala 
        35                  40                  45              


Ile Ala Lys Lys Ile Glu Glu Lys His Lys Ser Leu Leu Pro Glu Ser 
    50                  55                  60                  


Phe Arg Lys Thr Leu Ser Leu Gln Leu Lys Asn Ser Val Ala Lys Gly 
65                  70                  75                  80  


Lys Leu Val Lys Ile Arg Ala Ser Tyr Lys Leu Ser Asp Thr Thr Lys 
                85                  90                  95      


Met Ile Thr Arg Gln Gln Asp Lys Lys Asn Lys Lys Asn Met Lys Gln 
            100                 105                 110         


Glu Asp Lys Glu Ile Thr Lys Arg Thr Arg Ser Ser Ser Thr Arg Pro 
        115                 120                 125             


Lys Lys Thr Val Ser Val Asn Lys Gln Glu Lys Lys Arg Lys Val Lys 
    130                 135                 140                 


Lys Ala Arg Gln Pro Lys Ser Ile Lys Ser Ser Val Gly Lys Lys Lys 
145                 150                 155                 160 


Ala Met Lys Ala Ser Ala Ala 
                165         


<210>  25
<211>  167
<212>  PRT
<213>  A. thaliana

<400>  25

Met Ala Glu Asp Lys Ile Leu Lys Lys Thr Pro Ala Ala Lys Lys Pro 
1               5                   10                  15      


Arg Lys Pro Lys Thr Thr Thr His Pro Pro Tyr Phe Gln Met Ile Lys 
            20                  25                  30          


Glu Ala Leu Met Val Leu Lys Glu Lys Asn Gly Ser Ser Pro Arg Ala 
        35                  40                  45              


Ile Ala Lys Lys Ile Glu Glu Lys His Lys Ser Leu Leu Pro Glu Asn 
    50                  55                  60                  


Phe Arg Lys Arg Leu Ser Leu Gln Leu Lys Asn Arg Val Ala Lys Gly 
65                  70                  75                  80  


Lys Leu Val Lys Ile Arg Ala Ser Tyr Lys Leu Ser Asp Thr Thr Lys 
                85                  90                  95      


Met Ile Thr Arg Gln Gln Asp Lys Lys Asn Lys Lys Asn Met Lys Gln 
            100                 105                 110         


Glu Asp Lys Glu Ile Thr Lys Arg Thr Arg Ser Ser Ser Thr Arg Pro 
        115                 120                 125             


Lys Lys Thr Val Ser Val Asn Lys Gln Glu Lys Lys Arg Lys Val Lys 
    130                 135                 140                 


Lys Ala Arg Gln Pro Lys Ser Ile Lys Ser Ser Val Gly Lys Lys Lys 
145                 150                 155                 160 


Ala Met Lys Ala Ser Ala Ala 
                165         


