                               SEQUENCE LISTING

<110> CELL RESPONSE, INC.
 
<120> METHODS FOR TREATING MAP3K8 POSITIVE CANCERS

<130> 104016-1180110-000110PC

<140> PCT/US2020/020004
<141> 2020-02-26

<150> 62/810,520
<151> 2019-02-26

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 467
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Tyr Met Ser Thr Gly Ser Asp Asn Lys Glu Glu Ile Asp Leu 
1               5                   10                  15      


Leu Ile Lys His Leu Asn Val Ser Asp Val Ile Asp Ile Met Glu Asn 
            20                  25                  30          


Leu Tyr Ala Ser Glu Glu Pro Ala Val Tyr Glu Pro Ser Leu Met Thr 
        35                  40                  45              


Met Cys Gln Asp Ser Asn Gln Asn Asp Glu Arg Ser Lys Ser Leu Leu 
    50                  55                  60                  


Leu Ser Gly Gln Glu Val Pro Trp Leu Ser Ser Val Arg Tyr Gly Thr 
65                  70                  75                  80  


Val Glu Asp Leu Leu Ala Phe Ala Asn His Ile Ser Asn Thr Ala Lys 
                85                  90                  95      


His Phe Tyr Gly Gln Arg Pro Gln Glu Ser Gly Ile Leu Leu Asn Met 
            100                 105                 110         


Val Ile Thr Pro Gln Asn Gly Arg Tyr Gln Ile Asp Ser Asp Val Leu 
        115                 120                 125             


Leu Ile Pro Trp Lys Leu Thr Tyr Arg Asn Ile Gly Ser Asp Phe Ile 
    130                 135                 140                 


Pro Arg Gly Ala Phe Gly Lys Val Tyr Leu Ala Gln Asp Ile Lys Thr 
145                 150                 155                 160 


Lys Lys Arg Met Ala Cys Lys Leu Ile Pro Val Asp Gln Phe Lys Pro 
                165                 170                 175     


Ser Asp Val Glu Ile Gln Ala Cys Phe Arg His Glu Asn Ile Ala Glu 
            180                 185                 190         


Leu Tyr Gly Ala Val Leu Trp Gly Glu Thr Val His Leu Phe Met Glu 
        195                 200                 205             


Ala Gly Glu Gly Gly Ser Val Leu Glu Lys Leu Glu Ser Cys Gly Pro 
    210                 215                 220                 


Met Arg Glu Phe Glu Ile Ile Trp Val Thr Lys His Val Leu Lys Gly 
225                 230                 235                 240 


Leu Asp Phe Leu His Ser Lys Lys Val Ile His His Asp Ile Lys Pro 
                245                 250                 255     


Ser Asn Ile Val Phe Met Ser Thr Lys Ala Val Leu Val Asp Phe Gly 
            260                 265                 270         


Leu Ser Val Gln Met Thr Glu Asp Val Tyr Phe Pro Lys Asp Leu Arg 
        275                 280                 285             


Gly Thr Glu Ile Tyr Met Ser Pro Glu Val Ile Leu Cys Arg Gly His 
    290                 295                 300                 


Ser Thr Lys Ala Asp Ile Tyr Ser Leu Gly Ala Thr Leu Ile His Met 
305                 310                 315                 320 


Gln Thr Gly Thr Pro Pro Trp Val Lys Arg Tyr Pro Arg Ser Ala Tyr 
                325                 330                 335     


Pro Ser Tyr Leu Tyr Ile Ile His Lys Gln Ala Pro Pro Leu Glu Asp 
            340                 345                 350         


Ile Ala Asp Asp Cys Ser Pro Gly Met Arg Glu Leu Ile Glu Ala Ser 
        355                 360                 365             


Leu Glu Arg Asn Pro Asn His Arg Pro Arg Ala Ala Asp Leu Leu Lys 
    370                 375                 380                 


His Glu Ala Leu Asn Pro Pro Arg Glu Asp Gln Pro Arg Cys Thr Ser 
385                 390                 395                 400 


Leu Asp Ser Ala Leu Leu Glu Arg Lys Arg Leu Leu Ser Arg Lys Glu 
                405                 410                 415     


Leu Glu Leu Pro Glu Asn Ile Ala Asp Ser Ser Cys Thr Gly Ser Thr 
            420                 425                 430         


Glu Glu Ser Glu Met Leu Lys Arg Gln Arg Ser Leu Tyr Ile Asp Leu 
        435                 440                 445             


Gly Ala Leu Ala Gly Tyr Phe Asn Leu Val Arg Gly Pro Pro Thr Leu 
    450                 455                 460                 


Glu Tyr Gly 
465         


<210> 2
<211> 2763
<212> DNA
<213> Homo sapiens

<400> 2
ggatcccagt ggcccggcgt gctcggctcc cacaggcctg cagccagcat cgcaccgaac       60

cttcgggggg ccgcggctgg agcgctcggc cggcgtggga gcgcaaggcc gcagatgcaa      120

tcttcttacc gcgaagaagc caggggaata ggtagccaca tcttgtttgc agataagaaa      180

ggaagctaac gcagtatctg caaagccagg agtctgactc agtacttttc tcactcatgc      240

atacaagcag ctaaaaatga cacagcttat ttaccatgcc cctgacactg cactgagcac      300

tttatgagct tgaactctgt taatctcacg accacctcat gagactctcc agaaagagca      360

acagtaatgg agtacatgag cactggaagt gacaataaag aagagattga tttattaatt      420

aaacatttaa atgtgtctga tgtaatagac attatggaaa atctttatgc aagtgaagag      480

ccagcagttt atgaacccag tctaatgacc atgtgtcaag acagtaatca aaacgatgag      540

cgttctaagt ctctgctgct tagtggccaa gaggtaccat ggttgtcatc agtcagatat      600

ggaactgtgg aggatttgct tgcttttgca aaccatatat ccaacactgc aaagcatttt      660

tatggacaac gaccacagga atctggaatt ttattaaaca tggtcatcac tccccaaaat      720

ggacgttacc aaatagattc cgatgttctc ctgatcccct ggaagctgac ttacaggaat      780

attggttctg attttattcc tcggggcgcc tttggaaagg tatacttggc tcaagatata      840

aagacgaaga aaagaatggc gtgtaaactg atcccagtag atcaatttaa gccatctgat      900

gtggaaattc aggcttgctt ccggcacgag aacatcgcag agctgtatgg cgcagtcctg      960

tggggtgaaa ctgtccatct ctttatggaa gcaggcgagg gagggtctgt tctggagaaa     1020

ctggagagct gtggaccaat gagagaattt gaaattattt gggtgacaaa gcatgttctc     1080

aagggacttg attttctaca ctcaaagaaa gtgatccatc atgatattaa acctagcaac     1140

attgttttca tgtccacaaa agctgttttg gtggattttg gcctaagtgt tcaaatgacc     1200

gaagatgtct attttcctaa ggacctccga ggaacagaga tttacatgag cccagaggtc     1260

atcctgtgca ggggccattc aaccaaagca gacatctaca gcctgggggc cacgctcatc     1320

cacatgcaga cgggcacccc accctgggtg aagcgctacc ctcgctcagc ctatccctcc     1380

tacctgtaca taatccacaa gcaagcacct ccactggaag acattgcaga tgactgcagt     1440

ccagggatga gagagctgat agaagcttcc ctggagagaa accccaatca ccgcccaaga     1500

gccgcagacc tactaaaaca tgaggccctg aacccgccca gagaggatca gccacgctgt     1560

acgagtctgg actctgccct cttggagcgc aagaggctgc tgagtaggaa ggagctggaa     1620

cttcctgaga acattgctga ttcttcgtgc acaggaagca ccgaggaatc tgagatgctc     1680

aagaggcaac gctctctcta catcgacctc ggcgctctgg ctggctactt caatcttgtt     1740

cggggaccac caacgcttga atatggctga aggatgccat gtttgcctct aaattaagac     1800

agcattgatc tcctggaggc tggttctgct gcctctacac aggggcccgt tacagtgaat     1860

ggtgccattt tcgaaggagc agtgtgacct cctgtgaccc atgaatgtgc ctccaagcgg     1920

ccctgtgtgt ttgacatgtg aagctatttg atatgcacca ggtctcaagg ttctcatttc     1980

tcaggtgacg tgattctaag gcaggaattt gagagttcac agaaggatcg tgtctgctga     2040

ctgtttcatt cactgtgcac tttgctcaaa attttaaaaa taccaatcac aaggataata     2100

gagtagccta aaattactat tcttggttct tatttaagta tggaatattc attttactca     2160

gaatagcctg ttttgtgtat attggtgtat attatataac tctttgagcc tttattggta     2220

aattctggta tacattgaat tcattataat ttgggtgact agaacaactt gaagattgta     2280

gcaataagct ggactagtgt cctaaaaatg gctaactgat gaattagaag ccatctgaca     2340

gacggccact agtgacagtt tcttttgtgt tcctatggaa acattttata ctgtacatgc     2400

tatgctgaag acattcaaaa cgtgatgttt tgaatgtgga taaaactgtg taaaccacat     2460

aattttgtac atccaaggat gaggtgtgac ctttaagaaa aatgaaaact tttgtaaatt     2520

attgatgatt ttgtaattct tatgactaaa ttttctttta agcatttgta tattaaaata     2580

gcatactgtg tatgttttat atcaaatgcc ttcatgaatc tttcatacat atatatattt     2640

gtaacatgta aagtatgtga gtagtcttat gtaaagtatg tttttacatt atgcaaataa     2700

aacccaatac ttttgtccaa tgtggttggt caaatcaact gaataaattc agtattttgc     2760

ctt                                                                   2763


