                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Foerderung der Wissenschaften 
       e.V.
 
<120>  Method of identifying patients with bortezomib resistant multiple
        myeloma and other blood diseases

<130>  GAR-P04151WO

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  792
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(792)

<220>
<221>  gene
<222>  (1)..(792)
<223>  human PSMB5 nucleic acid

<400>  1
taccgcgaac ggtcgcacaa cctctctggc gatggccact tggtcgcgcc caaaaagcct       60

gaacccccag cacgtctaga cgacctagat ccaggtccct cagagtcact accagactcg      120

gaccggcgcg gtccgacccc acagggtctt ctcggtcctt agctttacga agtaccttgt      180

tggtgggacc ggaagttcaa ggcggtacct cagtatcaac gtcgactgag gtcccgatgt      240

cgcccacgaa tgtaacggag ggtctgccac ttcttccact atctctagtt gggtatggac      300

gatccgtggt accgaccccc gcgtcgccta acgtcgaaga cccttgccga caaccgagcc      360

gttacagctt agatactcga agctttattc cttgcgtaga gacatcgtcg acggaggttt      420

gacgaacggt tgtaccacat agtcatgttt ccgtaccccg acaggtaccc gtggtactag      480

acaccgaccc tattctctcc gggaccggag atgatgcacc tgtcacttcc cttggcctaa      540

agtccccggt ggaagagaca tccaagaccg agacacatac gtatacccca gtacctagcc      600

ccgataagga tactggacct tcacctcgtc cggatactag accgggcagc tcggtagatg      660

gttcggtgga tgtctctacg gatgagtcct ccacgtcagt tggagatggt gcacgccctc      720

ctaccgacct aggctcagag gtcactgtta caccgactag atgtactctt catatcaccg      780

agatggggga ct                                                          792


<210>  2
<211>  18678
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(18678)
<223>  huPSMB5 gene NC_000014.9

<400>  2
atggccgacc tcacttccct tacgcaacat ggacgttttc agtcacttcc tgtgattttg       60

aggttattct gatccaggac tacttgcatg accaaagcca agatggcagg tacgtccttt      120

tagaatttaa ggttagtgaa gccatctatt tccccgaccc ccttcagtga aaatggtctt      180

tcgcatctgg ctcttctttt tggaggcgtg cttgccagca gtcaaaatgg ctccattccg      240

gaatagattt aataggaagt gaagctgtga cggcgaggcg ttgcccggcc tatctttgct      300

aggcgttctc agaattagtt ctttctgccc acactagaca tggcgcttgc cagcgtgttg      360

gagagaccgc taccggtgaa ccagcgcggg tttttcggac ttgggggtcg tgcagatctg      420

ctggatctag gtccagggag tctcagtgat ggtctgagcc tggccgcgcc aggctggggt      480

gtcccagaag agccaggaat cgaaatgctt catggaacaa ccaccctggc cttcaaggtg      540

tggagccagc ccccttgcca ggctgagtac tgaacgcccg cgacttgcct ggcctcccag      600

cctgaccgga gtttgcggtg gccttggcca ccaacccagg cggaggctgg gtcctctcgt      660

tcggaccgca gcagttttgc tgtctcattg gcccaggagg cccctgtctt tgctctggtt      720

ggaaagggtg gcggtggggc cgggggtaag tcgggggagg aaggtgaggc ctcttgggtt      780

gattcctagg cgaccccagg ttgctgctgt tcaggatctt ctagctggga aaggccgcaa      840

caacaatgaa tcttggccga gggaaggcta ttgtaaacgt ttaccaaagt tttggaaact      900

gggcggcccc tcaaggcagg ggtaactgaa actggcatga aggggaagcg tggtgagggt      960

aagcattgta ctaagaatca gacatttggg gttccttgcc cagctctgca ataactagct     1020

ctagattgag aaatcatttg atttcattga acctgtttcc tcatctataa aatgatttgt     1080

tttttttttt tttttgaaac agggcttttc gctgtcgctc aggctggagt gcagtggctc     1140

cagcgcctca gcctccagag tagctgacac tataggcaca caccaccacg acaggctaag     1200

tttttttact ttttgtagag atggatctcc ctgtgttgcc caggctggtc tccagcacct     1260

ggcctcaagc ggtcctcccg ccttggtctc ccaaaatgcc tgggttacag gagtgagcca     1320

ccacgcccat cctataaaat gaatttaata tgggttatat ccatgtcaag ggattgatgt     1380

gaagctcggg tgacattaat atatggtgaa gtatagaagt atactgtgaa gtataaaagg     1440

acggagaaag agatgtgctg ggtttggatt gatgcaaaaa gaagtatgta ggagtgtttt     1500

tgtggtctta tgtggcctgt tttgtgtttt cctctgatct taacagttcc gccatggagt     1560

catagttgca gctgactcca gggctacagc gggtgcttac attgcctccc agacggtgaa     1620

gaaggtgata gagatcaacc catacctgct aggcaccatg gctgggggcg cagcggattg     1680

cagcttctgg gaacggctgt tggctcggca atgtcgaatc tatgagcttc gaaataagga     1740

acgcatctct gtagcagctg cctccaaact gcttgccaac atggtgtatc agtacaaagg     1800

catggggctg tccatgggca ccatgatctg tggctgggat aagagaggcc ctggtgagtt     1860

aagctgcaac cacatgatcc ttgggctgac actacagtga ggaggggttg gatggacaga     1920

tgaattaaag ggcttggtgt caatgctgaa gaagtgtaat taggtcctta gcccttcctt     1980

ctctcttttt ttttttcctg tttttttaga ctgtgtctca ttctgtcgct caggctggag     2040

tgcagtggca tgatctcagc tcactgcagc ctccgccccc aggttcagga attcaagacc     2100

agcctggcca acatggcgaa accccatctc tactaaaaat acaaaaatta gcccggcgtg     2160

gtggcgggcg cctgtaatac cagctgctca ggaggctgag gcatgagaat tgcttgaacc     2220

caggaggtgg atgttgcagt gagcagagat cgcgccactg cactccagcc tgggcgacag     2280

agtgagactc tgtctcaaaa aaaagaattt aagaattcgt tgaaggccgg gcgtggtggc     2340

tcactcctgt aatcccagca ctttgggagg ctgagacagt ggatcacgag gtcaggagat     2400

cgagaccatc ctggctaaca aggtgaaacc ccgtctctac caaaaataca aaaaattagc     2460

caggcgtggt ggcaggcgcc tgtagtccca gctactcagg aggctgaggc aggagaatag     2520

tgtgaaccca ggaggcggag cttgcagtga gtcgagatgg tgccactgca ctccagcctg     2580

ggcaacagag cgagactctg tctcaaaaaa aaaaacaaaa aaaagaattc gttgaatccc     2640

acatgtggca gtagtgctat ttcaagtgtt cattgaccat gtgtggcttg tggctactgt     2700

attggactct aatatatggt tgtccctcaa aagttagtca tttctcttct gtttttttct     2760

ttttttcttt ttttgagatg caaagtttca ctccgatcgt ccagtctggc gtgtaatggc     2820

attgtttcag ctcactacaa cctctgcctc ctgggttcaa gtgattctcc tgccgcagtc     2880

tcccaagtac ctgggattac aagcgcccac cagcatgccc agctaatttt atatttttag     2940

tagagatggg gtttcaccat gttggccagg ctggtctcga aatcctgacc tcaggtgatt     3000

cacccgcctc agcctcccaa agtgccagga ttaaaggcgt gagccgctgc acccggcctc     3060

ttctcttttt ttctttagag agtctttggc ctagaagggg ccttttgggc tcctctcttt     3120

tttgaggggg tggggatgga gtctcgctct gtcgccccga ctggagtgca gcggcgggat     3180

ctcagctcac tgcaatctct gcctcccagg ttcaagtgat tctcctgcct caaccttcca     3240

tgtagctgag actacaggca tatgccacca tgcgcgtcta atttttgtat ttttagtaga     3300

gacagggttt caccatgttg gccaggctgg tcttgaactc ctgacctcag gtgatctgcc     3360

cacctcagcc tgccaaagtg ttgagattac aggagtgagc cattgcgcct agtcctgggc     3420

tcatttcttt tatttctttg ctggttataa tcacccttac aatcatgcta ggtccggttc     3480

tatcatctct gaaaataagt tccttagcct gtttttcctt tccagcattt aagaaacttg     3540

ccagacagtt caactttgta tttaatgtca tttcctcatc agccagtttt gaattgcccg     3600

tttagtaaag ttggagtata gctagtcacc ttctaatttt cccttccata tgcttaaaaa     3660

taattattct ttcctccttt tgattttgct tcattcattt acctgcttac taaataccta     3720

gttatcttat agaacaatta tagggtacct accacttttt cacttgcttt caaacgagaa     3780

tagaaagggc tgtagggagt atccacttac tacccaatgg aggatgaaag gaaattaaaa     3840

accggatgtg agagaggagc tcactttgtt actttggaaa ttgagatgct tttctctgaa     3900

aggtgggaaa agacagttcc atacatttta cgtgatccag ggaagcattt tggaaatgtt     3960

gctttgaacc tttagctggc ggatttgttc taggtgatgg aaacagtgta aaagagtaca     4020

gggaccgggt aacaaggaaa atccagggag actgagcatc atttaaacag tgccttcttc     4080

aagaggcctt cctgatgacc ctgtcccatt cattgtgagt cagccccttg cctcatatta     4140

cagttggccc ttgagcaaca tgggtttgaa tcactcaggt ccacttatac gcaggtattt     4200

ttcaacctaa ttctgattga aaatacacat tcccagaatt tgaaacccaa atatacagag     4260

gaccaattta tttatttatt tatttattta tttttgagat ggagttttcc tcttgtcacc     4320

catgctggag tgcaatggcg cgatctcagt tcattgcaac ctccacctcc tgggttcaag     4380

tgatctcctg cctcagcctc ccgagtagct gggattacag acacccgcca ccctgccagc     4440

taacttttgt atttttagta gagacagggt ttcaccatgt tggccaggct ggtcttaaac     4500

tcctgacctc gggtgatcca cctgcctcag cctcccaaag tgctgggtgg cgtgagccac     4560

catatctggc caacttttca tatatgcagg ttctgcaggg ccaactttgg gacttgagtg     4620

tgcatagatt ttggtatatg caggggtctt gggacaaatc cccttcatat accaaaggat     4680

gactagttaa cccaaggctg aataagataa ataacctttt ttttttttta ttgagacgga     4740

gtctcgctct gtcgcccagg ctggagtgca gtggtgccat ctctgctcac tgcaagctcc     4800

gcctcccgga ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggtg     4860

cccgccacca cgcccggcta attttttgta tttttagtag agacggggtt tcactgtgtt     4920

agccaggatg gtctcaatct cctgacctca tgatccaccc gcctcggcct cccaaagtgc     4980

tgggattgca ggcgtgagcc acagctcctg gcctgataaa taccgttttt aaaagaacca     5040

gttggctggg catggtggct catgcctgta atctcagcac tttgggaggc cgagatgggt     5100

ggatcaccgg agatcaggag ttcgagacca gcctgaccaa catggtggaa ccttgtctct     5160

actaaaaata caaaattatt gggaggccga ggcgggcgga tcacgaggcc aggagatcga     5220

gaccatcctg gctaacacgg tgaaacccca tctctactaa aaatacaaaa aattagctgg     5280

gcgtggtggt ggtcgcctgt agtcccagct acttgggagg ctgaggcagg agaatggcgt     5340

gaacccagga ggtggagctt gcagtgagct gagatcgtgc cactgcactc cagactgggc     5400

aacagagcaa gactccatct caaaaaaaaa aaatacaaaa ttagccggct gtggtggcac     5460

atgcctgtaa tcccagctac tcagggagat gaggcaggag aatctcttga accctggagg     5520

tgcatgcctg taatcccagc tactcaggag gctgaggcag gagaatcaat cacttgaacc     5580

tgggaggcag aggttgcagt aagctgagat tgtgccattg cactccagct tgggaaacaa     5640

gaaagaaact ttgtctcaaa aatcagtcag tcaatcaata aataaaaaga accagtcaaa     5700

tgcggaagga gttttgagga ggaagagatt acttatgatg ggaggaattg gggaagactt     5760

catggattgg tggtggttgt cctggatgta aaaaagggaa agggaacata acaaagaaag     5820

ggaggaaaga agcatgagct tttgaggagt aactgaaagt ccagtttaat tggaactaag     5880

tgggtgaagg ggaatagtga gccataaagc cagaagggta ctttggaacc agatgatgac     5940

ccccctctag gcaagagagc atggcactgg ggctgaggag gggccagaga aaggagtaag     6000

gtagacatca gaatcacctg aacctgaaaa ccaataaggg cagaggtgct caagctggct     6060

tgcattaaaa tcacctgggg gacttaaaaa acaagttcca tacctgtttc ccaccccaca     6120

ccagttataa aaaataccta gggtaagtcc tgtgcatttt tgaaaaaaat ctttgttaga     6180

tgactctagt gcacagtgag atgtgagaat cactgaaaca ggaaaaagag tagtgatgct     6240

attggcagaa tttcagaaga caggaggaag cgtgggtttg tggcgcacaa gagagatgag     6300

tgtggtaggt aatggagaac cactggtatc taagtttagg aagtttgaat ctgtacatga     6360

tgacaaagac atccagctgg agggatccag taggcagttg ggattgaaca ctttgtctaa     6420

attttcatct gtaccaaaag tcagctagtt ttttcataaa gggccaaata gtaaatattt     6480

taggtctgca ggcctaaatc tttgtctcaa atacttaact ctgccggtgt tgcacaaaac     6540

aaccatagac agtatggaaa cagtggctct gttccaataa cattttaatt acaaaaataa     6600

aggcagttgg cctggccaaa ccctggtcta taccagcaat agaaatataa tgtgagccat     6660

atatgtaatt ttacatttta tactagctac gcttttaaaa ttaaaaaaaa ttaatttcaa     6720

tatattttgt ttaacctaat aaatccaaaa tattatgtta gcaggtagta ctagttcatt     6780

tcaaatgctc aactagtcct gtgtggctag tggctaccat atggacagtg caggtcttta     6840

caatgtgatt acaaactcta ggctttatta tcctcctgtg taaagtatgt cttgttctcc     6900

agatagtcta aactctttga gttctggcat tatggagttt gtttttctgt cacacaggct     6960

gcagtgcagt ggcataatca cagctcactg tagcctcaac ctcctgggct caagtgactg     7020

ggattatggg gtcttttgat gggggagtgg ggattatgtt ttgtttgttt gttttttgag     7080

acagagtttc actcttgttg cccaggctgg agtgcagtgg tgcgatctcg gctcactgca     7140

aactccacct cccaggttca agtgattctc ctgcctccgc ctcctgagta gctgggatta     7200

caggcatgcg ccaccacgcc tggctaattt tgtattttta gtagagacag ggtttctcca     7260

tgttggtcag gcttgtcttg aactcctgac ctcaggtgac ccacctgcct cggcctccca     7320

aagtgctggg attacgggtt tgagccactg cgcctggccg gggattatgt tttaaatgtt     7380

atctttcaca gtgtctgaag ttctgtgctt gaaacctaag tcatttggaa tgtacttgtt     7440

ttgtgggtgt gctgagagga tcggcaacat ggcaaggtag ttattataat ataaggtgag     7500

atggggtggt atgttgtaga atcctggagt cttaatatta aattttattc cttcaggttt     7560

tttttttttc ctgaagacag catctcagtc tgttgcccaa gctggagtgt ggtggtgtga     7620

ttatagctta ctgcagcctg caagtcctga gctcaaacaa tcctcctgtt tcaacctccc     7680

acagacatgc accaccacac tcagctagct tttaaaaaaa taataataat tttatagaag     7740

tcctatcttg tatttatgtt ggcttccctg ggtttctctt ttatatatat atatattatt     7800

ttatttattt attattatta ttattatttt tttttttttt gagacaaagt cttgctctgt     7860

ctcccaggct ggagtgcagt ggcgcgatct cggctcaccg caagctccgc ctcccgggtt     7920

tacgccattc tcctgcctca gcctcctgag tagctgggac tgcaggcgac cgcaaccaca     7980

cctggctaat tttttgtttt ttagtagaga cggggtttca ccgtgttagc caggatgatc     8040

tcgatctcct gacctcgtga tccacccgcc tcggcctccc aaagtgctgg gattacaggc     8100

gttagccacc gcgcctggcc tatttattat attattttga gacagcgttt cactcttgtt     8160

gcccaggctg gagtgcaatg gcgcgatctt ggcttaccgc aacctttgcc tcccaggttc     8220

aagtgattct cctgcatcag cctcctgagt agctgggatt ataggcatgt gccaccacgc     8280

ctggcaaatt ttgtattttt agtagagatg gggtttcttc atgttggtca ggctggtctc     8340

aaacgcctga cctcaggtga tctgcccacc tcagcctccc aaagtgctgg gattacaggc     8400

atgagccacc gcgcccggcc tattttttta tttttttaaa ttttattcta ggttttaaga     8460

gaactactgc tggccgggcg aggtggctca cgcctgtaat cccagcactt tgggagtccg     8520

agaagggcag atccccagag gtcaggagtt caagaccagc ctgaccaaca tggtgaaacc     8580

ccgtctctac taaaaataca aaaattagct gggcgtggtt acgagcgctt gtaatcctag     8640

ctacctggga aactgaggca ggagaatcac tttaacccag gaggcggagg ttgtggtgag     8700

ccgagattgc gccattgcac tctagcttgg gcaacaagag caaaactcca tctcaaaaaa     8760

aaagaactac tgccttggca tatgaattag atatcaaaag gggtgatctt tttttttttc     8820

ctgctaacct catctccctt tccaggcctc tactacgtgg acagtgaagg gaaccggatt     8880

tcaggggcca ccttctctgt aggttctggc tctgtgtatg catatggggt catggatcgg     8940

ggctattcct atgacctgga agtggagcag gcctatgatc tggcccgtcg agccatctac     9000

caagccacct acagagatgc ctactcagga ggtgcagtca acctctacca cgtgcgggag     9060

gatggctgga tccgagtctc cagtgacaat gtggctgatc tacatgagaa gtatagtggc     9120

tctaccccct gaaagagggt ggatgcagct gcttgtgttt cttggggtga ctgtcattgg     9180

taatacggac acagtgaccc atcctccatc ctatttatag tggaagggcc ttcaattgta     9240

tcagtacttt tttttaagct ctggcacatt gacctctatg tgttaccagt cattaatgag     9300

ctgctgcaga ggtgactatt tgttttactt tcttggatgt taacattaca ctactcacta     9360

ctcaatctca gcctgtgttg catcttttgt ccacactgtc cctcctccaa gcacttttca     9420

gtcaaataag ccaggacagt ggaagggaag tgactgtaat tacaggaaac agtggtgtga     9480

agacattgtc tagtgaatac attaatgtcc ccactcatga agctaataac ggagaaggag     9540

agagaggcag ggaggaggga gacacttctc gatttggttt acaaagagat gaaaagttga     9600

tgaggtggaa agatgcacag ggctgtacca ggcagggctc cagcggaaaa ggctgtcacc     9660

ctgtggtggg ggaagggagg ctgaggctac atgcagagcg gaagggtgaa gagggtaaat     9720

cttgactctt aaaccaactg ggaagggaag gcttggaccc tgggaagggg aggacaaaga     9780

agtggctgtg aaagcagtag taaccacaag cttggtgacc cttgtccttt tggtcctcca     9840

gtgcatatgt gtggagggga gagggtagtg atggtgattt tatagcctcc tggtcaggaa     9900

gcagcactaa attgtcactg gaatgtgtgg gtggggaaga ggccctgctg agagcagaga     9960

gatggctgat ttatcacacc cagcactgtt ggggctgggg ggagttccca agctatggtg    10020

gcagcagatg gcaaggcctt ctgttaaaga gaagacaggg gatagaggag gttgatggga    10080

gaaaccttta aaaaatggga gcggaggaca caaacaatac caccttgtat ttagtcagaa    10140

ggcagaaagt ggttggtgaa ggtgacaacc cagtgtcatg ttttgagact gagaggtttg    10200

gagaagtcat tcacagaaga agagggggta aaccctcctc tcctgtactg cagctacctt    10260

cccttccccc tcagccttgt gcagtcttcg tattgattga tgagggctgt cggccaggaa    10320

ctgatcgagg cttgttaatt gcatttgtca aatgcaggga aattgggaat tagtgaaatc    10380

ggagaagggg gtttggaaaa caaatgactc gtgcctaagg aaattttttg caggaaagta    10440

tctcaggagc ccctgcagtc agggagctgc tggtgtggac tcagactaca tggttgaaat    10500

aggcaggagc tgggcggggc acagtggctc aggcttgtaa tcccagcacc agcactttgg    10560

gagacggagg caggcagatc acttgatgcc aggagtttga gaccagtctg gccaacatgg    10620

tgaaacctgt ctctactaaa aatacgaaaa attagctggg tgtggtggca ggcacctgta    10680

atcccagcta cttgggaggc tgaggcagag gttgcagtga gccgagatgg tgccattgca    10740

ctccagcctg ggcaacaaaa gcaaaactcc atctaaaaaa aaaaagaaag aaagaaatag    10800

gcaggaccca agctacatct tccttctcgt agactgttgg gaaatggtta gctgcgtgag    10860

aagcacaggt aggtcatctt cctcccactt aggacattgg tttgcagatc ttaaaaaaaa    10920

aaaagaaaaa aaaaaaagca ctcttaggag aaatcccaat gcctgaaaaa aaaatcagag    10980

gttgaaattg agctgagagg tccagagcct ccactattga gcttccccat ccagccactc    11040

cccgcagcac cctttgttag ccccatacac atacacagtc cctggcactt cttggaacct    11100

caaggaacac aatttgaaca cctcttccct gggaaatagc cttaaggata gaaagagaat    11160

tgaagattgg aatttcctta catgacccca gagagcataa gaccccagct ttggtccatg    11220

aacagaaaat tcattctgga gagaagagat gatcgtgaaa caatgcaacc ctttgccctg    11280

tttctgtctc acactttgct ttggcagtgg tttagctgtt taacggaaac acctattctg    11340

cactggcaga gtccttatgt tagaagagaa aatgcatgtt ctgttctggc atatccctgt    11400

tgatctacct tcctgggtct tgggtaaaag actcatttaa tggaagagct cgatttgtgg    11460

taggtttttc tgggaagaaa gtagagcaga ggtagggaaa aactgcaagt ctgtaggcta    11520

gtggtatcca ccctgtgcat ttgtgatttc ttgctgatgg ttactggggg gaaattggct    11580

ttgcagcgat gtgtgtctcc gcttgtgtgg gaatgatgga tgccgcatag gattggagag    11640

atgtttttga gtggagtgta ccagttcagg gactcccatc agattcattt cccagtacag    11700

tcctcttgac aaaggatgat ggaaaagaaa tcgccttaaa tagctggaag attaatttct    11760

ctcagcagtt cccaggcgtc caagggactg ggctctttaa gtgatgtctg acaacttctc    11820

ttccctcaac agataactca gtaacaccaa aatctggctc ctcggggtag gtgatgggac    11880

taatctgatt aaatagggag caaatactcc tggaggcccc ttgctttctc ttgctagcct    11940

tccagcatct gcacaccagg caagggaggg ctgtggggag tagcagtgca ctgtggggtg    12000

agtagaatgt tcatgaagga aggtgaaaag gtaggtgagg atgtggggga ggagggagga    12060

agggcacagt taacgcaaat caaagactga aggataatag ttactgagtg ttcctcttta    12120

ggcaaaacca gaaggtcagt gtctcttgat atcctcctca gctagcaaat gagaaaactg    12180

tcagagccat ttggggagtg gaaggtcaca tcctccgagg ggaaataaaa taactgattt    12240

attctggccc acggattcta tgtggtctgt taggggaagg aagaaagagg tgggatgaaa    12300

agagaataaa gtagaaaaaa aaaggtggat ggaaattttg aggggagcat ttcccttgtg    12360

tcaggagtaa caaggatagg atgattgggt taggagagaa tctacatgac catatctaat    12420

tttcggtgga tacatttagg tttttaattt tcttttattt ttgtttcttt tgttagatct    12480

tcccctgacc tgctcccagg gctataacag atacggactt tgaaactgta tggagtatag    12540

agcagtgctc tataatttaa aatatacata tattgcaacc aagcacctct gctgttttgc    12600

gtttgtttct tgtttgtttt tataaattct agtttccctt caggaagcca gaatcatact    12660

gggaatgctt taattatagt gggcaagagg gagctcaaac agcaatcaga actgccctga    12720

tcagcagctg ctgccacctt ctacctgacc tgggccaccc ctctttttcc ccccaagtca    12780

gcctcccgtg ctccccaggc gtggcttcag agccaagttc tggtttccag gagctctgcc    12840

cccactgaag catttcaata aaaaacattt ctaaaatgtc ccctttgcag ttgttagtgg    12900

gtcaagcaga agaaattcta cccacgtcag cttcttgggc ttatttgacc caactcattt    12960

ctcccagaag cttttgcctc tgagttaggt gccaagctta agctggtatt taactcttta    13020

tggtccagat taagctgtca tcagccataa agatatgacc cagtttattt gaaaagaaat    13080

aagacaccat gggttcgaca cgttctgatg cttcccatta cttatccccg gccccatctt    13140

aggctgttcc tccctttgcc tcgttccatg ttttctctct gctctctcac tttataaaaa    13200

ttctctttcc tttgcagagt ttaaataaaa accaatcaat caataaacca agggctgctt    13260

ataggcttta ctgtaacaag aaaaggttat cattaactgc agggtaccca aaaagctggt    13320

attatagagg aaaacagatg gaatggcaga aagtgaacta gagagaacaa gagacaaacc    13380

agagacaaac aaaagcgact cccagacagc aagcgcgaga ttgagcaaag tgcagaggga    13440

gatgtgaacg tggcagagaa agatggatgg agatattgac aggcagagct ggactgtgaa    13500

tgggggcaga cagggagtgg gaaaggagac taagaaggac agtgatagag agagtgggca    13560

gaaaaacagg gaggaaggaa gcggctcgaa gctaatgcac agtgaaacat gtccccctgg    13620

agacagataa tttctccagc catacgtaat gaacacgtgc ctctctgtgt gttgcccctg    13680

tactgtcaca gtcacttaaa ttctgcaaga atctctccat gtctacacca cttatgcgag    13740

gttggaaaga aggtttgggc tctcacaacc cccatctcaa tccagccagg ccgaagacag    13800

aaaattagaa acctgtgtcg taaaagtaac agggtgagtg aggcaggatc acagatccag    13860

taccttcgaa aatttgtttt taggttcact aagaagcctt ctctccccac acctccatac    13920

tccctggcaa cacacatcat acacacataa ctcatcctct tttctgcaaa catgcctgca    13980

gatcagggcc tagggtgcct aagtcaggag agggaagcca ctacctccca ggaagactga    14040

ggaatagcac atgtcaggta agacgagaaa taagtaggtc caaatagaag taggtgtagc    14100

ctacaaggca ccaaggtaga ggggatgttt ttgcacgacc gcagctcttt tctcattcta    14160

gcctcaacac catcactatc ccagagacac ctatgcactc taagcctccc catgcataca    14220

gagtttcaca caatacacag gctttttttc acagcagctt atctccagcg gtgatgtgtg    14280

gtattgtctg attagaggga atcctctgag caccatggtt atgtgggagg gctcataatc    14340

accatgtctc ccttgagtct tgagtttgcg ctcatagctt agtctttaga aaagaaagca    14400

atggagcatt ttaaaccaac acaacatatt cagcatagtc ctgcatttcc aagcacctcc    14460

taaagaggaa aaatgcataa aggtggatca atccaagtgc ggtccttggc taggggtcag    14520

cactgttcta catctcattt aaacagcctt agggccaggt gccatggttc acacctataa    14580

tcccaacact ttgggaggcc aaggtgggag gatcacttga gctcaggagt tcaagaccat    14640

ctgggcaaaa taatgagacc cccatctcta caaaagatat taaaatttag ccaggtgtgg    14700

tggtacatac ctctagtacc agctcctcag gaggctgaag caaaaggatc acttgaacct    14760

gggacatgag gctgcaggga gctgtgatcg caccactgca ctccagcctg ggtgacagag    14820

ttagaccctg tctcaaacaa aacaaaacaa atcaaaaaac agccttaggc atgtgccaca    14880

tcaaacagca tctatgtagt gtctctggtt gtttcctggc atgtctgcct gctttttcag    14940

ttaagcacta tagtgtagtt tttacttgtt cccccacagt gtctagcatg ctgttggcta    15000

ctcaggaaag atatataata aatgtacttt taataaatga attaatgagg ctaggtgcat    15060

tagctgacgc ctgtaatcct aacactttgg gaggccgagg tgggtggatc acttgaggtc    15120

aggagttcga ggccagcctg gccaacgtgg tgaaactctg tctctactaa aatacaaaaa    15180

ttagctgggt gtggtggtgt gcacccgtaa tcccagctac ttgggaggct gaggcaagag    15240

aatcacttga actgcagcgc aggctgcact gagcagagat tccactagcc actatactcc    15300

agcctgggca acagagcaag actccactac aaaaaaaaaa aaaatacaga attaatgaat    15360

gattgccagg cgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcaggc    15420

ggatcacctg aggtcaggag atcgagacca gcctggctaa cacagtgaaa ccccatctct    15480

actaaaaata caaaaaaaaa ttagccgggc atggtggcag gcgcctgtag tcccagctac    15540

tcgggaggct gaggcaggag aatggcgaga acccgggagg cggaggttgc agtaagcaga    15600

gatagcgcca ctgcagtctg gcctggacga cagcgagact ccgtctcaaa aaaaaaaaaa    15660

aaaaaaaaag accagcctgg ccaacacggt gaaacctcgt ctctactaaa aatacaaaaa    15720

ttagccaggc gtggtggcag gcacctgtag tcccagctac tcgggagcct gaggcaggag    15780

aatcgcttga acctgggatg tggaggttgc agtgagccga gattgcgcca ttgcactcca    15840

gcctggggaa caagagcgag acttcatctc aaaaaaaaaa aaaaaaaaaa aaattaatga    15900

atgatttcac tatggtgtca ttttgccagt ggttcctacc cttcttagca ctgtgactcc    15960

catattgttt aattttaaga tgccctttgc tgctcttaaa catactatgg gccaggcacg    16020

gtggctcatg gctataatcc tagtgctttg ggaggccaag gcaggtggat cacctaaatt    16080

caggagttaa aaccagcctg gccaatatgg tgatgaaact ctgtctctat taaaaataca    16140

aaaatcagcc aggtgtggtg gcatgcgcct gtaatcccag ctactcagag gctgaggcag    16200

gagaatcact taaacctagg gggcagaggt tgcagtgaac caagattgta ccacttcgtt    16260

ccagcctggg tgaaagagtg aaactctgtc tcaaaaaaac aaaaaaacaa aaacaaaaac    16320

aaaaaaacta tgaaacgtat attaattttt aaaattaaga caaattaaaa ttacttgttt    16380

tgtgaatttc tttttttttt ttttgagaca gagtctcgct ctgtcgccca ggcaacattg    16440

gcgcaatctc ggctcactgc aatctctgcc tcccaggttc acgccattct cctgcctcag    16500

ccttcccagt agctggggct acaggcgccc gccaccatgc ccgctaattt ttgttttttt    16560

tgtatttttt agtagagacg gggtttcacc gtgttagcca ggatggtctt ttttgttttt    16620

ttgggacttt ttttttttct ttttgacacc actgcactct agcctgggcg acagagcgac    16680

actccatctc aaaaaaaaag aaataacata aatgtaaaga agataatgaa gaaggcaaag    16740

aggagaaaaa tgagtagata gatgccagct attatatgta gaagaaataa cagaatttga    16800

aaaatcacca tttggcaaac cccaatgcaa aaataggaag gtgcaaggtt gtggaagaac    16860

aggatattca cattatctaa gataatcact gtattagttt gctaaggctg ctataacaaa    16920

acaccatagt ctgagtggct taaacaacag aaattacttt ctcccagttc tggaggctgt    16980

aggtccaaga tcaaagtatc agcagtgttg atttcttctg aagcctcagt ccccttggct    17040

tgcagagagc tgccttctca ctgtatcctc acatggtctt tcctctgtgc accacaggta    17100

tctctttgtg tccaaattcc ctcttcttat aaggacacca gtcagactgg ctctacccta    17160

agtgcctcat ttaacttaat cacttcttta aagactcagt ctccaaatac agtcgaatcc    17220

tgaggtactg gaggttaggg cttcagtata taagttttag gggaacacat ttcagcccat    17280

aacaatcact ctatttatta ttagtttact aattaattac aaatggcaaa tatacttcta    17340

caacagagac gtctagcaga catgaataaa cttgcagtca ccaataatag aacaaactga    17400

cattatatgc ctcttgatgt gatacaataa gaagtatata aaattaccta agtaatattc    17460

tcgctaaaaa tgtttaacct tggccctgat gtggtggctc atgcctataa ttccagcatt    17520

tggggaggcc aaggcaggag gatcccttga gcccaggagt ttgagaccag ccggggcaac    17580

atagggggat cttgtctcta ccaagtaata actttttaaa attagcaggg catggtggca    17640

tgcacttgta gtcccaagct actcaggagg ctgaggcagg aggatggcat gagctttgga    17700

tgtcaaggct gcagtgaact gtgattacat cactgcactc cagcctgggt gacagagcaa    17760

gaccctgtat caaaaaagaa aaaaaaaaaa aagcttaacc tgaacctaat cacaagaaaa    17820

cagataaatc agattgcaaa taatgtcctg actcttccag tagaaacacc acgaaaaatt    17880

cacacacacc cacatggcaa aggagcacag cacttaggtg cagtgctgca gaatcctgtc    17940

ccacgcattg caaatgagct tgttctcggt cttgggacac ttgtggatgt accctgtatc    18000

ttcacagtac ttgattttca cagtaactgg ttgccaagga gaaaaaccat aaaggcacct    18060

ataatcccag cactttggga ggccgaggtg ggtggatcat ctgaggccag gagttcgaga    18120

ccagcctggc caacatggtg agaccccgtc tctactaaaa atgcaaaaat tagccgggac    18180

tggtggtgca tgcctgtaat cccagctact caggaggctg aggcaggaga atcgcttgaa    18240

cccaggagac agaggttgca gtaagccgag atagtgccac tgcactccag cctgggtgac    18300

agagcaagat tcagtctaaa aaaaaaaaaa aattagttgg gcgtggtgac gggtgcctgt    18360

aatcccagct actcaggagg ctgaggcagg agaattgctt gaacctggga gggagaggtt    18420

gcagagccaa gaccatgcca ctgcactcca gggtgggcaa gagactctat ctcacaacaa    18480

acaaacaaat agaaaacata aggggtacaa tttcacaaaa tcattaggtt ttaagatgag    18540

tgtgtgtatt tgaaagtttt gtgatgattg tttcttttct tgtaggttga aagaagctca    18600

aaggcaagaa tgttactttt gaattcccaa agtttcaatt gtaaacaaaa atgactaaat    18660

aaaatatcat tcacagtt                                                  18678


<210>  3
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  huPSMB5exon2_fwd

<400>  3
acggagaaag agatgtgctg g                                                 21


<210>  4
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  huPSMB5exon2_rev

<400>  4
agcattgaca ccaagccctt                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  huPSMB5exon3_fwd

<400>  5
tcctgctaac ctcatctccc t                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  huPSMB5exon3_rev

<400>  6
cttcccttcc actgtcctgg                                                   20


<210>  7
<211>  204
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(204)
<223>  human mature beta-5

<400>  7

Thr Thr Thr Leu Ala Phe Lys Phe Arg His Gly Val Ile Val Ala Ala 
1               5                   10                  15      


Asp Ser Arg Ala Thr Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys 
            20                  25                  30          


Lys Val Ile Glu Ile Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly 
        35                  40                  45              


Ala Ala Asp Cys Ser Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg 
    50                  55                  60                  


Ile Tyr Glu Leu Arg Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser 
65                  70                  75                  80  


Lys Leu Leu Ala Asn Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser 
                85                  90                  95      


Met Gly Thr Met Ile Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr 
            100                 105                 110         


Tyr Val Asp Ser Glu Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val 
        115                 120                 125             


Gly Ser Gly Ser Val Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser 
    130                 135                 140                 


Tyr Asp Leu Glu Val Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile 
145                 150                 155                 160 


Tyr Gln Ala Thr Tyr Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu 
                165                 170                 175     


Tyr His Val Arg Glu Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val 
            180                 185                 190         


Ala Asp Leu His Glu Lys Tyr Ser Gly Ser Thr Pro 
        195                 200                 


<210>  8
<211>  263
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PROPEP
<222>  (1)..(263)
<223>  human beta-5 propolypeptide

<400>  8

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 
                85                  90                  95      


Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 
            100                 105                 110         


Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 
        115                 120                 125             


Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 
    130                 135                 140                 


Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 
145                 150                 155                 160 


Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu 
                165                 170                 175     


Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val 
            180                 185                 190         


Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val 
        195                 200                 205             


Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr 
    210                 215                 220                 


Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu 
225                 230                 235                 240 


Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu 
                245                 250                 255     


Lys Tyr Ser Gly Ser Thr Pro 
            260             


<210>  9
<211>  3876
<212>  DNA
<213>  Mus musculus


<220>
<221>  gene
<222>  (1)..(3876)
<223>  mouse PSMB5 gene ID19173

<400>  9
aaacatggcg ctggctagcg tgttgcagcg gccgatgccg gtgaatcagc acgggttttt       60

tgggctcgga ggtggtgcag atctgctgga cttgggtccg gggagtcctg gtgatgggct      120

gagcctagcc gcgccgagct ggggcgtccc ggaggagccg cgaatcgaaa tgcttcacgg      180

aaccaccacc ctggccttca aggtgctcag acagctcgcg cttctccggc atcccagccg      240

gaaccgggtc gggcggaggt tcggtcccct cctcccgacc cttggcgggt tcactgtctc      300

gtagccttaa gaaaggagag gtgggcggag atagggggcg gtgagggaag gagacggaca      360

gcgtgggttg gctcctaggc gaccccagtt tgcccctttt caggagccct acctgggaac      420

agcggaccgt ggcggagggt gcggggggga agccattgtc gccgttcacc aaagtttgta      480

taaactgagc ttgatgaagt ccaggggcta ctgaagtggg taccgaacag ttagggtccc      540

tgttccagcc ctacaataac tagctctgga tcttaggcta gtctttaaag atttattctt      600

attttttgta tatacaccac gtgtgtagtg ctcgcaggcg ccaaaagagg gcgtcgtgtt      660

ccttgggact ggagttacag acctttgtga gcactgggaa ccgaacctct gaagagcagc      720

cagtgctctt aaccactgag ctctctctcc agtcccctta gggtgtcttt atctcattaa      780

acttgctact tcatatttaa agtgagtaaa agggctattc ataaatcagg aactgctgtt      840

aaacccgaat gacatttaac ataagaagtc gattacgccg ggtggtggtg gctcacgcct      900

ttagtcccag cacatgggag gcagaggcag gtggatttct gagttcgagg ccagcctggt      960

ctacaaagtg agttccagga cagccaggac tatacagaga aaccctgtct cgaaaaacaa     1020

aaacaaaccc caaacccccc aaaaaagaag tcgattccaa aatcccaaaa gatgcaaagc     1080

caggttatct ttctgtattt atacaaaaat aaagtatggg gagtatttgt ggtcttacgg     1140

ggcctctctt tttgttttct ctgaccttaa ctagtttctc catggagtca ttgttgcagc     1200

ggattcccgg gccacagcag gtgcttatat tgcttcccag acggtgaaga aagtaataga     1260

gatcaacccg taccttctgg gcaccatggc tgggggtgca gcggattgca gcttctggga     1320

gcggttgttg gctcggcagt gtcgaatcta tgagcttcgc aataaggaac gcatctcggt     1380

cgcagcagcc tccaaactgc tcgctaacat ggtgtatcag tacaaaggca tggggctgtc     1440

tatgggcacc atgatctgtg gctgggataa gagaggccct ggtgagttgt gtcctgtgag     1500

ccatggtggg aaggggttaa atgggtggga gaattgaggg cttttaacag gtgctgggaa     1560

tggatgcgat attaggttct cagctcttcc ttccctttcc aaggaaggcc ttgtacggaa     1620

taggaaagag catagagtta gacttgctgt gtcactcact gcttagtcat ttgaccttag     1680

cctatttctt catctgggaa ctggttaagt gaaccattga agcggttaag tgtggtgcac     1740

atagagcaat tggtacaatg tctggcacaa cagctctcct tctttcccat gcaataatga     1800

ctagaaaaca tttgtactgg ggaattgtaa actttaaaaa ttgtgttcta ttctagccag     1860

gtgtggtggc acatgccttt aatcccaaca cttgggaggc agaggcaggc ggatttctga     1920

gttcgaggcc agcctggtct acaaagtgag ttccaggaca gccagggcta tacagagaaa     1980

ccctgtctca aaaaaccaaa agaaaaaaaa ttgtgttctt ttctatgctt gggtgttttg     2040

tctgcatgta tgactgtgca ccacagtgca ttcatggtgc ctgaagaggc cagagagggg     2100

attggatcct ctagaatgca gttactgatg gttgtgagcc acatgtgggt gctcagagct     2160

aaacccaggt ccttggcaag agtggcccgt ccttcttccc cctgccctgg gggccatctc     2220

cccagccccc cccccacttt taaattttaa gttaaattat ttatttgtgt gtgtatgtgt     2280

gaacaaacac atcctacagc atatctgcag ttcagaggat aacttgttca agttggttct     2340

cttgttctgt gggccgggct caggacatca ggcctggtgg taagcaacag ttatatgctg     2400

actcacctca ctggccctca ttgtaaaaaa taaataagcc aagtgataca cagctgtgac     2460

cctagagcac tagggagggt caagagttcg aggccagcct aagctgtatg gcagaaggac     2520

agcctggagc acacagaaac attgtatctc agaagtcagt aaaactagtg gagttggtgt     2580

atagttaatt ttatataaaa tgcccaaatt atttctcagt acctggcggt agtaccattt     2640

caagtgttga agtcagtttc atgcagtctc tagccactgt gttgcatgac aacgataggc     2700

tacagagttg tcatttaagc gttatctccc accattcctg agtcctgtgc ttgacttggc     2760

cagcatgctt gccttttgga gttgccgaga gagcaggagg gatggttaac atactgtgag     2820

gagagatggg tggtatggtg ctctggaatc tggaaatctc aagataaatt tgactctgtc     2880

tttctctgat ttcttgaaaa tttgtttctt tatgagtttc tgtatgggta tgtgagtgtt     2940

tgcatgtgta tatgtgtgta taccacttgc atgcctggtg cccacagagg acagaagaag     3000

gtattgcatc cccagagact ggagttacag acagttgcga gccaccccgt gtatattggg     3060

aactgaacct gggtcctaga caagagcaac aagcactctt aactgccgag gaagctttct     3120

agcccgtttt gttttgagac agggttttat gtagcccagg ctgacctcaa acttaataca     3180

tagtcaagcc tagcctttaa ctcctgatcc tcctgccttc acctcccaag tgtgctgaga     3240

tttgtttttg ttttgtttgt ttgtttgttt ggttggttgg ttggttggtt ttttgttttt     3300

tcgagacagg gtttctctgt gtagccctgg ctgtcctgga cctcactttg tagaccaggc     3360

tggcctcgta ctcagaaatc ctcctgtctc tgcctcccaa ggagatccta tttttgtcgg     3420

ggtggggcgg ggtggtgtgt gtgagagaga gagagaggga ggggtgttaa aatgacgtct     3480

tttttctcgt tccctgctca cctcatcccc tcaggcctct actacgtaga cagcgagggg     3540

aacaggatct ctgggaccgc cttctcagtg ggctctggct ccgtgtatgc ttacggcgtt     3600

atggatcgag gctactccta tgacctgaaa gtggaggagg cctatgatct ggcccgccga     3660

gccatctacc aagccaccta cagagatgcc tactccggag gggcagtcaa cctctaccac     3720

gtgcgggagg atggctggat ccgggtgtcc agtgacaatg tagctgactt acatgacaag     3780

tacagtagtg tatctgtccc ctgagggaag gtggatgcgg ttgtctgcat ctctaggtgg     3840

gtctccatgg ctataataaa taatagtacc tctttc                               3876


<210>  10
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  msPSMB5exon2_fwd

<400>  10
gtatttgtgg tcttacgggg c                                                 21


<210>  11
<211>  22
<212>  DNA
<213>  Mus musculus


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  msPSMB5exon2_rev

<400>  11
aaccagttcc cagatgaaga aa                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Mus musculus


<220>
<221>  gene
<222>  (1)..(20)
<223>  msPSMB5exon3_fwd

<400>  12
gggtggtgtg tgtgagagag                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Mus musculus


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  msPSMB5exon3_rev

<400>  13
ccagggttcg ggggagatat                                                   20


<210>  14
<211>  205
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(205)
<223>  mouse beta-5 peptide

<400>  14

Thr Thr Thr Leu Ala Phe Lys Phe Leu His Gly Val Ile Val Ala Ala 
1               5                   10                  15      


Asp Ser Arg Ala Thr Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys 
            20                  25                  30          


Lys Val Ile Glu Ile Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly 
        35                  40                  45              


Ala Ala Asp Cys Ser Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg 
    50                  55                  60                  


Ile Tyr Glu Leu Arg Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser 
65                  70                  75                  80  


Lys Leu Leu Ala Asn Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser 
                85                  90                  95      


Met Gly Thr Met Ile Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr 
            100                 105                 110         


Tyr Val Asp Ser Glu Gly Asn Arg Ile Ser Gly Thr Ala Phe Ser Val 
        115                 120                 125             


Gly Ser Gly Ser Val Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser 
    130                 135                 140                 


Tyr Asp Leu Lys Val Glu Glu Ala Tyr Asp Leu Ala Arg Arg Ala Ile 
145                 150                 155                 160 


Tyr Gln Ala Thr Tyr Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu 
                165                 170                 175     


Tyr His Val Arg Glu Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val 
            180                 185                 190         


Ala Asp Leu His Asp Lys Tyr Ser Ser Val Ser Val Pro 
        195                 200                 205 


<210>  15
<211>  264
<212>  PRT
<213>  Mus musculus


<220>
<221>  PROPEP
<222>  (1)..(264)
<223>  mouse beta-5 propolypeptide

<400>  15

Met Ala Leu Ala Ser Val Leu Gln Arg Pro Met Pro Val Asn Gln His 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Gly Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Pro Gly Asp Gly Leu Ser Leu Ala Ala Pro Ser Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Arg Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Phe Leu His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 
                85                  90                  95      


Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 
            100                 105                 110         


Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 
        115                 120                 125             


Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 
    130                 135                 140                 


Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 
145                 150                 155                 160 


Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu 
                165                 170                 175     


Gly Asn Arg Ile Ser Gly Thr Ala Phe Ser Val Gly Ser Gly Ser Val 
            180                 185                 190         


Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Lys Val 
        195                 200                 205             


Glu Glu Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr 
    210                 215                 220                 


Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu 
225                 230                 235                 240 


Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Asp 
                245                 250                 255     


Lys Tyr Ser Ser Val Ser Val Pro 
            260                 


<210>  16
<211>  507
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(507)
<223>  Human PSMB5 Exon 2 Sequence shown in Figure 2A

<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  Binding site for huPSMB5exon2_rev

<220>
<221>  primer_bind
<222>  (487)..(507)
<223>  Binding site for huPSMB5exon2_fwd

<400>  16
agcattgaca ccaagccctt taattcatct gtccatccaa cccctcctca ctgtagtgtc       60

agcccaagga tcatgtggtt gcagcttaac tcaccagggc ctctcttatc ccagccacag      120

atcatggtgc ccatggacag ccccatgcct ttgtactgat acaccatgtt ggcaagcagt      180

ttggaggcag ctgctacaga gatgcgttcc ttatttcgaa gctcatagat tcgacattgc      240

cgagccaaca gccgttccca gaagctgcaa tccgctgcgc ccccagccat ggtgcctagc      300

aggtatgggt tgatctctat caccttcttc accgtctggg aggcaatgta agcacccgct      360

gtagccctgg agtcagctgc aactatgact ccatggcgga actgttaaga tcagaggaaa      420

acacaaaaca ggccacataa gaccacaaaa acactcctac atacttcttt ttgcatcaat      480

ccaaacccag cacatctctt tctccgt                                          507


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Leu Met Ser Val Leu Gly Lys Leu Glu Asp Thr Trp Gly Val Gly Gly 
1               5                   10                  15      


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gln Leu Thr Leu Gly Leu Ile Met His Asn Cys Ser Leu Glu Gly Pro 
1               5                   10                  15      


Gly Arg Lys Asp Trp Gly Cys Ile Met Thr Gly Met Ser Leu Gly Met 
            20                  25                  30          


Gly Lys Tyr Gln Tyr Val Met Asn Ala Leu Leu Lys Ser Ala Ala Ala 
        35                  40                  45              


Val Ser Ile Arg Glu Lys Asn Arg Leu Glu Tyr Ile Arg Cys Gln Arg 
    50                  55                  60                  


Ala Leu Leu Arg Glu Trp Phe Ser Cys Asp Ala Ala Gly Gly Ala Met 
65                  70                  75                  80  


Thr Gly Leu Leu Tyr Pro Asn Ile Glu Ile Val Lys Lys Val Thr Gln 
                85                  90                  95      


Ser Ala Ile Tyr Ala Gly Ala Thr Ala Arg Ser Asp Ala Ala Val Ile 
            100                 105                 110         


Val Gly His Arg Phe Gln 
        115             


<210>  19
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Leu Phe Val Cys Phe Leu Gly Cys Leu Val Val Phe Val Ser Arg Cys 
1               5                   10                  15      


Val Glu Lys Gln Met Leu Gly Phe Gly Ala Cys Arg Lys Arg Arg 
            20                  25                  30      


<210>  20
<211>  632
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(632)
<223>  Human PSMB5 Exon 3 Sequence shown in Figure 2B.

<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  Binding site for huPSMB5exon3_rev

<220>
<221>  primer_bind
<222>  (612)..(632)
<223>  Binding site for huPSMB5exon3_fwd

<400>  20
cttcccttcc actgtcctgg cttatttgac tgaaaagtgc ttggaggagg gacagtgtgg       60

acaaaagatg caacacaggc tgagattgag tagtgagtag tgtaatgtta acatccaaga      120

aagtaaaaca aatagtcacc tctgcagcag ctcattaatg actggtaaca catagaggtc      180

aatgtgccag agcttaaaaa aaagtactga tacaattgaa ggcccttcca ctataaatag      240

gatggaggat gggtcactgt gtccgtatta ccaatgacag tcaccccaag aaacacaagc      300

agctgcatcc accctctttc agggggtaga gccactatac ttctcatgta gatcagccac      360

attgtcactg gagactcgga tccagccatc ctcccgcacg tggtagaggt tgactgcacc      420

tcctgagtag gcatctctgt aggtggcttg gtagatggct cgacgggcca gatcataggc      480

ctgctccact tccaggtcat aggaatagcc ccgatccatg accccatatg catacacaga      540

gccagaacct acagagaagg tggcccctga aatccggttc ccttcactgt ccacgtagta      600

gaggcctgga aagggagatg aggttagcag ga                                    632


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Lys Gly Glu Val Thr Arg Ala 
1               5           


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Lys Val Ser Phe His Lys Ser Ser Pro Cys His Pro Cys Phe Ile Cys 
1               5                   10                  15      


Cys Leu Ser Leu Asn Leu Leu Ser Tyr His Leu Thr Leu Met Trp Ser 
            20                  25                  30          


Leu Leu Val Phe Leu 
        35          


<210>  23
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Arg Gln Leu Leu Glu Asn Ile Val Pro Leu Val Tyr Leu Asp Ile His 
1               5                   10                  15      


Trp Leu Lys Phe Phe Leu Val Ser Val Ile Ser Pro Gly Glu Val Ile 
            20                  25                  30          


Phe Leu Ile Ser Ser Pro Asp Ser His Gly Tyr 
        35                  40              


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Trp His Cys Asp Gly Trp Ser Val Cys Ala Ala Ala Asp Val Arg Lys 
1               5                   10                  15      


<210>  25
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Pro Thr Ser Gly Ser Tyr Lys Glu His Leu Asp Ala Val Asn Asp Ser 
1               5                   10                  15      


Ser Val Arg Ile Trp Gly Asp Glu Arg Val His Tyr Leu Asn Val Ala 
            20                  25                  30          


Gly Gly Ser Tyr Ala Asp Arg Tyr Thr Ala Gln Tyr Ile Ala Arg Arg 
        35                  40                  45              


Ala Leu Asp Tyr Ala Gln Glu Val Glu Leu Asp Tyr Ser Tyr Gly Arg 
    50                  55                  60                  


Asp Met Val Gly Tyr Ala Tyr Val Ser Gly Ser Gly Val Ser Phe Thr 
65                  70                  75                  80  


Ala Gly Ser Ile Arg Asn Gly Glu Ser Asp Val Tyr Tyr Leu Gly Pro 
                85                  90                  95      


Phe Pro Ser Ser Thr Leu Leu Val 
            100                 


<210>  26
<211>  584
<212>  DNA
<213>  Mus musculus


<220>
<221>  gene
<222>  (1)..(584)
<223>  Mouse PSMB5 Exon 2 Sequence shown in Figure 3A

<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  Binding site for msPSMB5exon2_rev

<220>
<221>  primer_bind
<222>  (564)..(584)
<223>  Binding site for msPSMB5exon2_fwd

<400>  26
aaccagttcc cagatgaaga aataggctaa ggtcaaatga ctaagcagtg agtgacacag       60

caagtctaac tctatgctct ttcctattcc gtacaaggcc ttccttggaa agggaaggaa      120

gagctgagaa cctaatatcg catccattcc cagcacctgt taaaagccct caattctccc      180

acccatttaa ccccttccca ccatggctca caggacacaa ctcaccaggg cctctcttat      240

cccagccaca gatcatggtg cccatagaca gccccatgcc tttgtactga tacaccatgt      300

tagcgagcag tttggaggct gctgcgaccg agatgcgttc cttattgcga agctcataga      360

ttcgacactg ccgagccaac aaccgctccc agaagctgca atccgctgca cccccagcca      420

tggtgcccag aaggtacggg ttgatctcta ttactttctt caccgtctgg gaagcaatat      480

aagcacctgc tgtggcccgg gaatccgctg caacaatgac tccatggaga aactagttaa      540

ggtcagagaa aacaaaaaga gaggccccgt aagaccacaa atac                       584


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Gly Thr Gly Leu His Leu Phe Leu Ser Leu Asp Phe Ser 
1               5                   10              


<210>  28
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Ala Thr Leu Ser Val Ala Leu Arg Val Arg His Glu Lys Arg Asn Arg 
1               5                   10                  15      


Val Leu Gly Glu Lys Ser Leu Ser Pro Leu Ala Ser Phe Arg Ile Asp 
            20                  25                  30          


Cys Gly Asn Gly Ala Gly Thr Leu Leu Gly 
        35                  40          


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Asn Glu Trp Gly Asn Leu Gly Lys Gly Gly His Ser Val Pro Cys Leu 
1               5                   10                  15      


Glu Gly Pro Gly Arg Lys Asp Trp Gly Cys Ile Met Thr Gly Met Ser 
            20                  25                  30          


Leu Gly Met Gly Lys Tyr Gln Tyr Val Met Asn Ala Leu Leu Lys Ser 
        35                  40                  45              


Ala Ala Ala Val Ser Ile Arg Glu Lys Asn Arg Leu Glu Tyr Ile Arg 
    50                  55                  60                  


Cys Gln Arg Ala Leu Leu Arg Glu Trp Phe Ser Cys Asp Ala Ala Gly 
65                  70                  75                  80  


Gly Ala Met Thr Gly Leu Leu Tyr Pro Asn Ile Glu Ile Val Lys Lys 
                85                  90                  95      


Val Thr Gln Ser Ala Ile Tyr Ala Gly Ala Thr Ala Arg Ser Asp Ala 
            100                 105                 110         


Ala Val Ile Val Gly His Leu Phe 
        115                 120 


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Asn Leu Asp Ser Phe Val Phe Leu Ser Ala Gly Tyr Ser Trp Leu Tyr 
1               5                   10                  15      


<210>  31
<211>  585
<212>  DNA
<213>  Mus musculus


<220>
<221>  gene
<222>  (1)..(585)
<223>  Mouse PSMB5 Exon 3 Sequence shown in Figure 3B.

<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  Binding site for msPSMB5exon3_rev

<220>
<221>  primer_bind
<222>  (566)..(585)
<223>  Binding site for msPSMB5exon3_fwd

<400>  31
ccagggttcg ggggagatat aaacaagaag aatcaggact gaataaactg ctgttagaag       60

gactggtggt cgcgtcgttc ttgctggtcg agagcgggcg cgacacaaag gcactgaaat      120

aactgtggac tccactctga aagaggtact attatttatt atagccatgg agacccacct      180

agagatgcag acaaccgcat ccaccttccc tcaggggaca gatacactac tgtacttgtc      240

atgtaagtca gctacattgt cactggacac ccggatccag ccatcctccc gcacgtggta      300

gaggttgact gcccctccgg agtaggcatc tctgtaggtg gcttggtaga tggctcggcg      360

ggccagatca taggcctcct ccactttcag gtcataggag tagcctcgat ccataacgcc      420

gtaagcatac acggagccag agcccactga gaaggcggtc ccagagatcc tgttcccctc      480

gctgtctacg tagtagaggc ctgaggggat gaggtgagca gggaacgaga aaaaagacgt      540

cattttaaca cccctccctc tctctctctc tcacacacac caccc                      585


<210>  32
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Trp Pro Glu Pro Ser Ile Tyr Val Leu Leu Ile Leu Val Ser Tyr Val 
1               5                   10                  15      


Ala Thr Leu Leu Val Pro Pro Arg Thr Thr Arg Ala Pro Arg Ser Arg 
            20                  25                  30          


Ala Arg Cys Leu Pro Val Ser Ile Val Thr Ser Glu Val Arg Phe Ser 
        35                  40                  45              


Thr Ser Asn Asn Ile Ile Ala Met Ser Val Trp Arg Ser Ile Cys Val 
    50                  55                  60                  


Val Ala Asp Val Lys Gly 
65                  70  


<210>  33
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Pro Val Ser Val Ser Ser Tyr Lys Asp His Leu Asp Ala Val Asn Asp 
1               5                   10                  15      


Ser Ser Val Arg Ile Trp Gly Asp Glu Arg Val His Tyr Leu Asn Val 
            20                  25                  30          


Ala Gly Gly Ser Tyr Ala Asp Arg Tyr Thr Ala Gln Tyr Ile Ala Arg 
        35                  40                  45              


Arg Ala Leu Asp Tyr Ala Glu Glu Val Lys Leu Asp Tyr Ser Tyr Gly 
    50                  55                  60                  


Arg Asp Met Val Gly Tyr Ala Tyr Val Ser Gly Ser Gly Val Ser Phe 
65                  70                  75                  80  


Ala Thr Gly Ser Ile Arg Asn Gly Glu Ser Asp Val Tyr Tyr Leu Gly 
                85                  90                  95      


Ser Pro Ile Leu His Ala Pro Phe Ser Phe Phe Ser Thr Met Lys Val 
            100                 105                 110         


Gly Arg Gly Arg Glu Arg Glu 
        115                 


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Val Cys Trp Gly 
1               


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 1

<400>  35
gaccttaact agtttctcca                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 2

<400>  36
gagagatcaa cccgtacctt c                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 3

<400>  37
gccatggtgc ccagaaggta                                                   20


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 4

<400>  38
gcagcttctg ggagcggttg t                                                 21


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 5

<400>  39
catgttagcg agcagtttgg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 6

<400>  40
gtctacgtag tagaggcctg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 7

<400>  41
cgtgtatgct tacggcgtta                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 8

<400>  42
ggctcggcgg gccagatcat                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Guide 9

<400>  43
tccagccatc ctcccgcacg                                                   20


<210>  44
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A20T

<400>  44
catcgtgccg aggaggtacg ggtttatctc tattactttc ttcaccgtct gggaagcaat       60

ataagcacct gctgtggtcc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  45
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A20V

<400>  45
catcgtgccg aggaggtacg ggtttatctc tattactttc ttcaccgtct gggaagcaat       60

ataagcacct gctgtgaccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  46
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template T21A

<400>  46
catcgtgccg aggaggtacg ggtttatctc tattactttc ttcaccgtct gggaagcaat       60

ataagcacct gctgcggccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  47
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template T21I

<400>  47
gctgcaatcc gctgcacccc cagccatcgt gccgaggagg tacgggttta tctctattac       60

tttcttcacc gtctgggaag caatataagc acctgctatg gcccgggaat ccgctgcaac      120

aatgactcca tgcaggaact agttgaggtc agagaaaaca aaaagagagg ccccgtaaga      180

ccac                                                                   184


<210>  48
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template V31L

<400>  48
catcgtgccg aggaggtacg ggtttatctc tattactttc ttcaacgtct gggaagcaat       60

ataagcacct gctgtggccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  49
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template V31E

<400>  49
catcgtgccg aggaggtacg ggtttatctc tattactttc ttctccgtct gggaagcaat       60

ataagcacct gctgtggccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  50
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template V31G

<400>  50
catcgtgccg aggaggtacg ggtttatctc tattactttc ttccccgtct gggaagcaat       60

ataagcacct gctgtggccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  51
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template M45V

<400>  51
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccgctgca       60

cccccagcca cggtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  52
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template M45I

<400>  52
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccgctgca       60

cccccagcaa tggtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  53
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A49E

<400>  53
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccgcttca       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  54
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A49T

<400>  54
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccgctgta       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  55
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template C63F

<400>  55
tgatacacca tattagcgag cagcttggat gctgctgcga ccgagatgcg ttccttattg       60

cgaagctcat agattcgaaa ctgccgagct aacaatcgct cccagaaact gcaatccgct      120


<210>  56
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template C63Y

<400>  56
tgatacacca tattagcgag cagcttggat gctgctgcga ccgagatgcg ttccttattg       60

cgaagctcat agattcgata ctgccgagct aacaatcgct cccagaaact gcaatccgct      120


<210>  57
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template S130A

<400>  57
agtagcctcg atccattacg ccataagcat agacggagcc agcgcccact gagaaggcgg       60

tcccagagat cctgttcccc tcgctatcta catagtacag gcctgagggg atgaggtgag      120


<210>  58
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template Y169D

<400>  58
tggacacccg gatccatcca tcctcccgga cgtgatagag gttgactgcc cctccggagt       60

cggcatctct gtaggtggct tggtagatgg cgcggcgggc caggtcataa gcctcctcca      120


<210>  59
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template Y169N

<400>  59
tggacacccg gatccatcca tcctcccgga cgtgatagag gttgactgcc cctccggagt       60

tggcatctct gtaggtggct tggtagatgg cgcggcgggc caggtcataa gcctcctcca      120


<210>  60
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A27V

<400>  60
gctgcaatcc gctgcacccc cagccatcgt gccgaggagg tacgggttta tctctattac       60

tttcttcacc gtctgggaaa caatataagc acctgctgtg gcccgggaat ccgctgcaac      120

aatgactcca tgcaggaact agttgaggtc agagaaaaca aaaagagagg ccccgtaaga      180

ccac                                                                   184


<210>  61
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template V31L

<400>  61
catcgtgccg aggaggtacg ggtttatctc tattactttc ttcaacgtct gggaagcaat       60

ataagcacct gctgtggccc gggaatccgc tgcaacaatg actccatgca ggaacta         117


<210>  62
<211>  163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A49V

<400>  62
gagatgcgtt ccttattgcg aagctcatag attcgacact gccgagctaa caagcgctcc       60

cagaaactgc aatccgctac acccccagcc atcgtgccga ggaggtacgg gtttatctct      120

attactttct tcaccgtctg ggaagcaata taagcacctg ctg                        163


<210>  63
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A49S

<400>  63
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccgctgaa       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  64
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A50E

<400>  64
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atcctctgca       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  65
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template A50V

<400>  65
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgca atccactgca       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  66
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template C52F

<400>  66
agctcataga ttcgacactg ccgagctaac aagcgctccc agaaactgaa atccgctgca       60

cccccagcca tcgtgccgag gaggtacggg tttatctcta ttactttctt caccgtctgg      120


<210>  67
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template C63W

<400>  67
tgatacacca tattagcgag cagcttggat gctgctgcga ccgagatgcg ttccttattg       60

cgaagctcat agattcgcca ctgccgagct aacaatcgct cccagaaact gcaatccgct      120


<210>  68
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template Y169H

<400>  68
tggacacccg gatccatcca tcctcccgga cgtgatagag gttgactgcc cctccggagt       60

gggcatctct gtaggtggct tggtagatgg cgcggcgggc caggtcataa gcctcctcca      120


<210>  69
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR/Cas9_Repair template G183D

<400>  69
gacagataca ctactgtact tgtcatgtaa atcagctaca ttatcactag acacccggat       60

ccagtcatcc tcccggacgt gatagaggtt gactgcccct ccggagtagg catctctgta      120


