                         SEQUENCE LISTING

<110>  The State of Israel, Ministry of Agriculture & Rural 
       Development, Agricultural Research Organization (ARO) (Volcani 
       Center)
       CINNAMON, Yuval
       BEN-TAL COHEN, Enbal
 
<120>  GENOME-EDITED BIRDS

<130>  P-585110-PC

<150>  62/814,162
<151>  2019-03-05

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA1-CRISPER-HA2

<400>  1
aacacagctt atatacattt ttacctacaa aatcgtgctg tcatgtccca ctctgattgg       60

ttcataccag ataacgtgcc ttatttggcc gtttccacat tcttttctca tccttcttct      120

cctgttttct ctgcatcaag gtcagcacg                                        149


<210>  2
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPER WT Sequence

<400>  2
ataccagata acgtgcctta tttggccgtt                                        30


<210>  3
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPER Mutant Sequence

<400>  3
ataccagata acgtaatcct tatttggccg tt                                     32


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 1

<400>  4
ttttgaatga agggcctgag                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  5
ggttggttca ctgttgtctg                                                   20


<210>  6
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 3

<400>  6
gtccctcttc tcttatggag atcgccgttt ccacattctt ttctc                       45


<210>  7
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 4

<400>  7
ggtggcactt ttcggggaaa tgtgtgaacc aatcagagtg ggacatgac                   49


<210>  8
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 5

<400>  8
gtcatgtccc actctgattg gttcacacat ttccccgaaa agtgccacc                   49


<210>  9
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 6

<400>  9
gagaaaagaa tgtggaaacg gcgatctcca taagagaaga gggac                       45


<210>  10
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 7

<400>  10
gaagtgtgct gctaacctg                                                    19


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 8

<400>  11
gctatgaact aatgaccccg                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 9

<400>  12
ttttcctcct ctcctgacta c                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 10

<400>  13
ggcctggatg ataagagtct tc                                                22


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 11

<400>  14
gctattcggc tatgactggg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 12

<400>  15
gaaggcgata gaaggcgatg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 13

<400>  16
gtggaacaca gcttttccag                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 14

<400>  17
gctcttcaac ttgccatttg                                                   20


<210>  18
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 15

<400>  18
tcaacagcac gtaagcaac                                                    19


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 16

<400>  19
cctgactcca tttttgagcc                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 17

<400>  20
cccaaatata acacgcttca ct                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 18

<400>  21
gaaatgaatt attttctggc gac                                               23


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 19

<400>  22
agctctttct cgattccgtg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 20

<400>  23
gggtagacac aagctgagcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 21

<400>  24
caactatcag gctccaccac                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 22

<400>  25
ctcagacggt tttcagggtt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 23

<400>  26
aggctatggg atgatgcaag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 24

<400>  27
gtaggtaggc gatccgttca                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 25

<400>  28
cgagaccaac gtgaagggaa                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 26

<400>  29
cagacccgga caacgtcttt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 27

<400>  30
ctctggggct cacctacaag                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 28

<400>  31
agccctggtg aaatgtaggg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 29

<400>  32
agctctcatc tcaaggcaca                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 30

<400>  33
ggaaagatcc actgcttcca                                                   20


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 31

<400>  34
agcacaggtg gtgaacgaac ca                                                22


<210>  35
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 32

<400>  35
tccaggcctc ttgatgctac cga                                               23


<210>  36
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 34

<400>  36
caccgccaaa taaggcacgt tatc                                              24


<210>  37
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 35

<400>  37
aaacgataac gtgccttatt tggc                                              24


<210>  38
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 36

<400>  38
caccgaccag ataacgtgcc ttatt                                             25


<210>  39
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 37

<400>  39
aaacaataag gcacgttatc tggt                                              24


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 38

<400>  40
ttgcagtggt taccgttcg                                                    19


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 39

<400>  41
tagtaggcat cttgtggggg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 40

<400>  42
atgaatggag ctataggagg                                                   20


<210>  43
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 41

<400>  43
ccacgtctcc tgcttgcttt aacagagaga agttcgtggc atcgccatct tccagcaggc       60

g                                                                       61


<210>  44
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 42

<400>  44
tgttaaagca agcaggagac gtggaagaaa accccggtcc tatgaagatg gacaaaaaga       60

c                                                                       61


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 43

<400>  45
ttacagcccg gaccgacgat g                                                 21


<210>  46
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 44

<400>  46
atctgacccg ggatgaatgg agctatagga gg                                     32


<210>  47
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 45

<400>  47
gtagctgcta gcttacagcc cggaccgacg atg                                    33


<210>  48
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 46

<400>  48
caggtccccg ggatggatcc tgatgatgtt g                                      31


<210>  49
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer 47

<400>  49
gcatgtgcta gcttagagct ttaaatctct g                                      31


<210>  50
<211>  9289
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pX330-GFP

<400>  50
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ggtcttcgag aagacctgtt ttagagctag aaatagcaag ttaaaataag      300

gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttg ttttagagct      360

agaaatagca agttaaaata aggctagtcc gtttttagcg cgtgcgccaa ttctgcagac      420

aaatggctct agaggtaccc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      480

ccaacgaccc ccgcccattg acgtcaatag taacgccaat agggactttc cattgacgtc      540

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      600

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tgtgcccagt      660

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      720

ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      780

ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg      840

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      900

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc      960

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgacgc     1020

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg     1080

accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg ctgtaattag     1140

ctgagcaaga ggtaagggtt taagggatgg ttggttggtg gggtattaat gtttaattac     1200

ctggagcacc tgcctgaaat cacttttttt caggttggac cggtgccacc atggactata     1260

aggaccacga cggagactac aaggatcatg atattgatta caaagacgat gacgataaga     1320

tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc gacaagaagt     1380

acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc accgacgagt     1440

acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac agcatcaaga     1500

agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc acccggctga     1560

agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat ctgcaagaga     1620

tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg gaagagtcct     1680

tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac atcgtggacg     1740

aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa ctggtggaca     1800

gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg atcaagttcc     1860

ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg gacaagctgt     1920

tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc aacgccagcg     1980

gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg ctggaaaatc     2040

tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg attgccctga     2100

gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat gccaaactgc     2160

agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag atcggcgacc     2220

agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg ctgagcgaca     2280

tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg atcaagagat     2340

acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag cagctgcctg     2400

agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc tacattgacg     2460

gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa aagatggacg     2520

gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag cagcggacct     2580

tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc attctgcggc     2640

ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag aagatcctga     2700

ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga ttcgcctgga     2760

tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg gtggacaagg     2820

gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac ctgcccaacg     2880

agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat aacgagctga     2940

ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc ggcgagcaga     3000

aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg aagcagctga     3060

aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc ggcgtggaag     3120

atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc aaggacaagg     3180

acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg accctgacac     3240

tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac ctgttcgacg     3300

acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg ctgagccgga     3360

agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat ttcctgaagt     3420

ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc ctgaccttta     3480

aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac gagcacattg     3540

ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg aaggtggtgg     3600

acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc gaaatggcca     3660

gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg aagcggatcg     3720

aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg gaaaacaccc     3780

agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat atgtacgtgg     3840

accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc gtgcctcaga     3900

gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac aagaaccggg     3960

gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac tactggcggc     4020

agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc aaggccgaga     4080

gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg gtggaaaccc     4140

ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact aagtacgacg     4200

agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag ctggtgtccg     4260

atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac caccacgccc     4320

acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac cctaagctgg     4380

aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg atcgccaaga     4440

gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac atcatgaact     4500

ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct ctgatcgaga     4560

caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc accgtgcgga     4620

aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag acaggcggct     4680

tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc agaaagaagg     4740

actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat tctgtgctgg     4800

tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa gagctgctgg     4860

ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt ctggaagcca     4920

agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac tccctgttcg     4980

agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag aagggaaacg     5040

aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac tatgagaagc     5100

tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag cacaagcact     5160

acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc ctggccgacg     5220

ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc atcagagagc     5280

aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct gccgccttca     5340

agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag gtgctggacg     5400

ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac ctgtctcagc     5460

tgggaggcga caaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     5520

aattcggcag tggagagggc agaggaagtc tgctaacatg cggtgacgtc gaggagaatc     5580

ctggcccagt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc     5640

tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca     5700

cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc     5760

ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca     5820

tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca     5880

tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca     5940

ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg     6000

ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga     6060

agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc     6120

tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca     6180

accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca     6240

tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca     6300

aggaattcta actagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc     6360

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     6420

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     6480

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gagaatagca ggcatgctgg     6540

ggagcggccg caggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     6600

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     6660

agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt ttctccttac     6720

gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc gccctgtagc     6780

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     6840

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     6900

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     6960

ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc gccctgatag     7020

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     7080

actggaacaa cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg     7140

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac     7200

aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc tgatgccgca     7260

tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     7320

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     7380

ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta     7440

taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat     7500

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     7560

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa     7620

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac     7680

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac     7740

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt     7800

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc     7860

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca     7920

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc     7980

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     8040

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     8100

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     8160

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     8220

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     8280

gctggctggt ttattgctga taaatctgga gccggtgagc gtggaagccg cggtatcatt     8340

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     8400

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     8460

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     8520

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     8580

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     8640

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     8700

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     8760

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     8820

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     8880

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     8940

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     9000

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     9060

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     9120

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     9180

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     9240

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgt                 9289


<210>  51
<211>  9291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR1

<400>  51
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ccaaataagg cacgttatcg ttttagagct agaaatagca agttaaaata      300

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt tgttttagag      360

ctagaaatag caagttaaaa taaggctagt ccgtttttag cgcgtgcgcc aattctgcag      420

acaaatggct ctagaggtac ccgttacata acttacggta aatggcccgc ctggctgacc      480

gcccaacgac ccccgcccat tgacgtcaat agtaacgcca atagggactt tccattgacg      540

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      600

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attgtgccca      660

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      720

taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc      780

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg      840

gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg      900

gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag      960

gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgac     1020

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac     1080

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt     1140

agctgagcaa gaggtaaggg tttaagggat ggttggttgg tggggtatta atgtttaatt     1200

acctggagca cctgcctgaa atcacttttt ttcaggttgg accggtgcca ccatggacta     1260

taaggaccac gacggagact acaaggatca tgatattgat tacaaagacg atgacgataa     1320

gatggcccca aagaagaagc ggaaggtcgg tatccacgga gtcccagcag ccgacaagaa     1380

gtacagcatc ggcctggaca tcggcaccaa ctctgtgggc tgggccgtga tcaccgacga     1440

gtacaaggtg cccagcaaga aattcaaggt gctgggcaac accgaccggc acagcatcaa     1500

gaagaacctg atcggagccc tgctgttcga cagcggcgaa acagccgagg ccacccggct     1560

gaagagaacc gccagaagaa gatacaccag acggaagaac cggatctgct atctgcaaga     1620

gatcttcagc aacgagatgg ccaaggtgga cgacagcttc ttccacagac tggaagagtc     1680

cttcctggtg gaagaggata agaagcacga gcggcacccc atcttcggca acatcgtgga     1740

cgaggtggcc taccacgaga agtaccccac catctaccac ctgagaaaga aactggtgga     1800

cagcaccgac aaggccgacc tgcggctgat ctatctggcc ctggcccaca tgatcaagtt     1860

ccggggccac ttcctgatcg agggcgacct gaaccccgac aacagcgacg tggacaagct     1920

gttcatccag ctggtgcaga cctacaacca gctgttcgag gaaaacccca tcaacgccag     1980

cggcgtggac gccaaggcca tcctgtctgc cagactgagc aagagcagac ggctggaaaa     2040

tctgatcgcc cagctgcccg gcgagaagaa gaatggcctg ttcggaaacc tgattgccct     2100

gagcctgggc ctgaccccca acttcaagag caacttcgac ctggccgagg atgccaaact     2160

gcagctgagc aaggacacct acgacgacga cctggacaac ctgctggccc agatcggcga     2220

ccagtacgcc gacctgtttc tggccgccaa gaacctgtcc gacgccatcc tgctgagcga     2280

catcctgaga gtgaacaccg agatcaccaa ggcccccctg agcgcctcta tgatcaagag     2340

atacgacgag caccaccagg acctgaccct gctgaaagct ctcgtgcggc agcagctgcc     2400

tgagaagtac aaagagattt tcttcgacca gagcaagaac ggctacgccg gctacattga     2460

cggcggagcc agccaggaag agttctacaa gttcatcaag cccatcctgg aaaagatgga     2520

cggcaccgag gaactgctcg tgaagctgaa cagagaggac ctgctgcgga agcagcggac     2580

cttcgacaac ggcagcatcc cccaccagat ccacctggga gagctgcacg ccattctgcg     2640

gcggcaggaa gatttttacc cattcctgaa ggacaaccgg gaaaagatcg agaagatcct     2700

gaccttccgc atcccctact acgtgggccc tctggccagg ggaaacagca gattcgcctg     2760

gatgaccaga aagagcgagg aaaccatcac cccctggaac ttcgaggaag tggtggacaa     2820

gggcgcttcc gcccagagct tcatcgagcg gatgaccaac ttcgataaga acctgcccaa     2880

cgagaaggtg ctgcccaagc acagcctgct gtacgagtac ttcaccgtgt ataacgagct     2940

gaccaaagtg aaatacgtga ccgagggaat gagaaagccc gccttcctga gcggcgagca     3000

gaaaaaggcc atcgtggacc tgctgttcaa gaccaaccgg aaagtgaccg tgaagcagct     3060

gaaagaggac tacttcaaga aaatcgagtg cttcgactcc gtggaaatct ccggcgtgga     3120

agatcggttc aacgcctccc tgggcacata ccacgatctg ctgaaaatta tcaaggacaa     3180

ggacttcctg gacaatgagg aaaacgagga cattctggaa gatatcgtgc tgaccctgac     3240

actgtttgag gacagagaga tgatcgagga acggctgaaa acctatgccc acctgttcga     3300

cgacaaagtg atgaagcagc tgaagcggcg gagatacacc ggctggggca ggctgagccg     3360

gaagctgatc aacggcatcc gggacaagca gtccggcaag acaatcctgg atttcctgaa     3420

gtccgacggc ttcgccaaca gaaacttcat gcagctgatc cacgacgaca gcctgacctt     3480

taaagaggac atccagaaag cccaggtgtc cggccagggc gatagcctgc acgagcacat     3540

tgccaatctg gccggcagcc ccgccattaa gaagggcatc ctgcagacag tgaaggtggt     3600

ggacgagctc gtgaaagtga tgggccggca caagcccgag aacatcgtga tcgaaatggc     3660

cagagagaac cagaccaccc agaagggaca gaagaacagc cgcgagagaa tgaagcggat     3720

cgaagagggc atcaaagagc tgggcagcca gatcctgaaa gaacaccccg tggaaaacac     3780

ccagctgcag aacgagaagc tgtacctgta ctacctgcag aatgggcggg atatgtacgt     3840

ggaccaggaa ctggacatca accggctgtc cgactacgat gtggaccata tcgtgcctca     3900

gagctttctg aaggacgact ccatcgacaa caaggtgctg accagaagcg acaagaaccg     3960

gggcaagagc gacaacgtgc cctccgaaga ggtcgtgaag aagatgaaga actactggcg     4020

gcagctgctg aacgccaagc tgattaccca gagaaagttc gacaatctga ccaaggccga     4080

gagaggcggc ctgagcgaac tggataaggc cggcttcatc aagagacagc tggtggaaac     4140

ccggcagatc acaaagcacg tggcacagat cctggactcc cggatgaaca ctaagtacga     4200

cgagaatgac aagctgatcc gggaagtgaa agtgatcacc ctgaagtcca agctggtgtc     4260

cgatttccgg aaggatttcc agttttacaa agtgcgcgag atcaacaact accaccacgc     4320

ccacgacgcc tacctgaacg ccgtcgtggg aaccgccctg atcaaaaagt accctaagct     4380

ggaaagcgag ttcgtgtacg gcgactacaa ggtgtacgac gtgcggaaga tgatcgccaa     4440

gagcgagcag gaaatcggca aggctaccgc caagtacttc ttctacagca acatcatgaa     4500

ctttttcaag accgagatta ccctggccaa cggcgagatc cggaagcggc ctctgatcga     4560

gacaaacggc gaaaccgggg agatcgtgtg ggataagggc cgggattttg ccaccgtgcg     4620

gaaagtgctg agcatgcccc aagtgaatat cgtgaaaaag accgaggtgc agacaggcgg     4680

cttcagcaaa gagtctatcc tgcccaagag gaacagcgat aagctgatcg ccagaaagaa     4740

ggactgggac cctaagaagt acggcggctt cgacagcccc accgtggcct attctgtgct     4800

ggtggtggcc aaagtggaaa agggcaagtc caagaaactg aagagtgtga aagagctgct     4860

ggggatcacc atcatggaaa gaagcagctt cgagaagaat cccatcgact ttctggaagc     4920

caagggctac aaagaagtga aaaaggacct gatcatcaag ctgcctaagt actccctgtt     4980

cgagctggaa aacggccgga agagaatgct ggcctctgcc ggcgaactgc agaagggaaa     5040

cgaactggcc ctgccctcca aatatgtgaa cttcctgtac ctggccagcc actatgagaa     5100

gctgaagggc tcccccgagg ataatgagca gaaacagctg tttgtggaac agcacaagca     5160

ctacctggac gagatcatcg agcagatcag cgagttctcc aagagagtga tcctggccga     5220

cgctaatctg gacaaagtgc tgtccgccta caacaagcac cgggataagc ccatcagaga     5280

gcaggccgag aatatcatcc acctgtttac cctgaccaat ctgggagccc ctgccgcctt     5340

caagtacttt gacaccacca tcgaccggaa gaggtacacc agcaccaaag aggtgctgga     5400

cgccaccctg atccaccaga gcatcaccgg cctgtacgag acacggatcg acctgtctca     5460

gctgggaggc gacaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa     5520

ggaattcggc agtggagagg gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa     5580

tcctggccca gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga     5640

gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc     5700

cacctacggc aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg     5760

gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca     5820

catgaagcag cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac     5880

catcttcttc aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga     5940

caccctggtg aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct     6000

ggggcacaag ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca     6060

gaagaacggc atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca     6120

gctcgccgac cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga     6180

caaccactac ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca     6240

catggtcctg ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta     6300

caaggaattc taactagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca     6360

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     6420

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     6480

gggggtgggg tggggcagga cagcaagggg gaggattggg aagagaatag caggcatgct     6540

ggggagcggc cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     6600

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     6660

tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt     6720

acgcatctgt gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta     6780

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     6840

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     6900

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     6960

acctcgaccc caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat     7020

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     7080

aaactggaac aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc     7140

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     7200

acaaaatatt aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg     7260

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     7320

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     7380

ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt     7440

tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa     7500

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     7560

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     7620

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     7680

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     7740

acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt     7800

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     7860

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     7920

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     7980

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     8040

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     8100

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa     8160

tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     8220

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     8280

cggctggctg gtttattgct gataaatctg gagccggtga gcgtggaagc cgcggtatca     8340

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     8400

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     8460

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     8520

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     8580

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     8640

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     8700

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     8760

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     8820

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     8880

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     8940

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     9000

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     9060

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     9120

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     9180

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     9240

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg t              9291


<210>  52
<211>  9292
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR3

<400>  52
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg accagataac gtgccttatt gttttagagc tagaaatagc aagttaaaat      300

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga      360

gctagaaata gcaagttaaa ataaggctag tccgttttta gcgcgtgcgc caattctgca      420

gacaaatggc tctagaggta cccgttacat aacttacggt aaatggcccg cctggctgac      480

cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact ttccattgac      540

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      600

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc      660

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      720

ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      780

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      840

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc      900

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga      960

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga     1020

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga     1080

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat     1140

tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt aatgtttaat     1200

tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc accatggact     1260

ataaggacca cgacggagac tacaaggatc atgatattga ttacaaagac gatgacgata     1320

agatggcccc aaagaagaag cggaaggtcg gtatccacgg agtcccagca gccgacaaga     1380

agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg atcaccgacg     1440

agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg cacagcatca     1500

agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag gccacccggc     1560

tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc tatctgcaag     1620

agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga ctggaagagt     1680

ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc aacatcgtgg     1740

acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag aaactggtgg     1800

acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac atgatcaagt     1860

tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac gtggacaagc     1920

tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc atcaacgcca     1980

gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga cggctggaaa     2040

atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac ctgattgccc     2100

tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag gatgccaaac     2160

tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc cagatcggcg     2220

accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc ctgctgagcg     2280

acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct atgatcaaga     2340

gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg cagcagctgc     2400

ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc ggctacattg     2460

acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg gaaaagatgg     2520

acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg aagcagcgga     2580

ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac gccattctgc     2640

ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc gagaagatcc     2700

tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc agattcgcct     2760

ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa gtggtggaca     2820

agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag aacctgccca     2880

acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg tataacgagc     2940

tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg agcggcgagc     3000

agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc gtgaagcagc     3060

tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc tccggcgtgg     3120

aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt atcaaggaca     3180

aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg ctgaccctga     3240

cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc cacctgttcg     3300

acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc aggctgagcc     3360

ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg gatttcctga     3420

agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac agcctgacct     3480

ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg cacgagcaca     3540

ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca gtgaaggtgg     3600

tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg atcgaaatgg     3660

ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga atgaagcgga     3720

tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc gtggaaaaca     3780

cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg gatatgtacg     3840

tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat atcgtgcctc     3900

agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc gacaagaacc     3960

ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag aactactggc     4020

ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg accaaggccg     4080

agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag ctggtggaaa     4140

cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac actaagtacg     4200

acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc aagctggtgt     4260

ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac taccaccacg     4320

cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag taccctaagc     4380

tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag atgatcgcca     4440

agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc aacatcatga     4500

actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg cctctgatcg     4560

agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt gccaccgtgc     4620

ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg cagacaggcg     4680

gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc gccagaaaga     4740

aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc tattctgtgc     4800

tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg aaagagctgc     4860

tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac tttctggaag     4920

ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag tactccctgt     4980

tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg cagaagggaa     5040

acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc cactatgaga     5100

agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa cagcacaagc     5160

actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg atcctggccg     5220

acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag cccatcagag     5280

agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc cctgccgcct     5340

tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa gaggtgctgg     5400

acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc gacctgtctc     5460

agctgggagg cgacaaaagg ccggcggcca cgaaaaaggc cggccaggca aaaaagaaaa     5520

aggaattcgg cagtggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga     5580

atcctggccc agtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     5640

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     5700

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     5760

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     5820

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     5880

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     5940

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     6000

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     6060

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     6120

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     6180

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     6240

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     6300

acaaggaatt ctaactagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     6360

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     6420

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     6480

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagagaata gcaggcatgc     6540

tggggagcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     6600

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     6660

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     6720

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     6780

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     6840

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     6900

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     6960

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     7020

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     7080

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     7140

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     7200

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     7260

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     7320

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     7380

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     7440

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     7500

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     7560

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     7620

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     7680

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     7740

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     7800

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     7860

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     7920

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     7980

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     8040

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     8100

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     8160

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     8220

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     8280

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtggaag ccgcggtatc     8340

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     8400

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     8460

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     8520

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     8580

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     8640

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     8700

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     8760

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     8820

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     8880

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     8940

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     9000

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     9060

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     9120

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     9180

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     9240

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             9292


<210>  53
<211>  6061
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pJet-Has

<400>  53
gcccctgcag ccgaattata ttatttttgc caaataattt ttaacaaaag ctctgaagtc       60

ttcttcattt aaattcttag atgatacttc atctggaaaa ttgtcccaat tagtagcatc      120

acgctgtgag taagttctaa accatttttt tattgttgta ttatctctaa tcttactact      180

cgatgagttt tcggtattat ctctattttt aacttggagc aggttccatt cattgttttt      240

ttcatcatag tgaataaaat caactgcttt aacacttgtg cctgaacacc atatccatcc      300

ggcgtaatac gactcactat agggagagcg gccgccagat cttccggatg gctcgagttt      360

ttcagcaaga tttttgaatg aagggcctga gggtgggcag tctgtctatc atgtacatct      420

ccatattctg ggaggtcgtc agttgggctg gcctcctggc taagattttt gcaccacaag      480

agatgctgca tgtgtacaaa tcactagcaa atagatttgt ttcccatcaa cttagccact      540

gttaatgtaa attgttcttg gatatgtgtc tttggagggc aataaatgct ctgaacagca      600

cttgcacaat aaagatacag catgtgggaa tgatctgtct catgtgtctt actgatggta      660

ttggttctgt aagataaaat attgtgtctg ggatgtgttt ggctctacta ttaatggtgc      720

tctattgatt gtgatttgtc atttgaaacc tgaggatgcg actgtatagc agtctttcat      780

gcatttttgg aaaaaaactt aagctttttg aaagctgctg ctacaacttt ttgtattgtt      840

ataaagtttt gtattgtttt tttaattgtg aaattataaa gatgccgtgc agggactgtt      900

tgaagcaaag tgcattgttt tagaaaccta caactctagt tcaagcactc catcagtatc      960

tgcttaatct ttgtcatcct ttgctatgag aaaatattaa gcagtagtct aaaggtacta     1020

tgaaactata acatagctga cattgtattt ataactacgt catgattttg atagaattga     1080

ggacttgaaa atgttaaact attcatgtag ggcctcttaa gatgcttaag ttgtttagta     1140

atgtaagtgt gcatttaatt gagattttat tgggcataat ttgtccatca gtatgacact     1200

ccttgtcagt gttgccttat acttgatgtt gttaccggat ctctgcaagg cagttattct     1260

tgaattaggc tcattgaagt gtctgccagt ataaatatat agcaactgtt ctttgtgtta     1320

aaattgagaa gctaaccagt ttttagtgct tctgactgtt ggaattcttt aagcagatgc     1380

cataagaaaa ttgtatttgt gatcaccact tctccagagt ggttttaaca ccaagggcat     1440

tagagaaaga aaggcaggcg tgtagagaat agtggacaga caaaagctgt gagttacgtt     1500

atgtttttca gctgaaaagc tgtgtttggt aaaagcatat gaaatcactc aacttggaag     1560

cattctctta gttctctgat agttctgagc agcagaactc ttcacctaag aggttacttc     1620

aactggaaga ctacctagtg cttctgatgg caactatatt taagatgaga ataagaggtg     1680

tttccagtgt ggtagcctca catctgttgc agtggttacc gttcgtcctc ctccgaggga     1740

cacagcttgg ccattcactg tggtgacacc aatatgatga tcagcaaatg gtgtttattc     1800

actactaaac acagcttata tacattttta cctacaaaat cgtgctgtca tgtcccactc     1860

tgattggttc ataccagata acgtgcctta tttggccgtt tccacattct tttctcatcc     1920

ttcttctcct gttttctctg catcaaggtc agcacgatag cactgtctct ctatgcttag     1980

ggagaggcct gtcctgtaca tcccgtgccc ccacaagatg cctactacaa caacatcttc     2040

tgcatgtcct gcatagcagt gttgggagaa tgtgcactac ttccactctt ctgatttcta     2100

ttttatgtgt ttgctttata ccagtgttgc catttgggaa ttaatacatg gttgatcaaa     2160

tcaattgcat cacagctgta tcctgtatca gaggaacatt atcaaagctt ttgttgctgt     2220

atttggtatc tgacctgcag ataaacatgt tttaggaagg ttttgcaaaa gtagctgtga     2280

aatgagctgg tgttgtgatt taacctgaca ggcagctaaa cagtatacca cagagctatt     2340

cacctacttt ccctcagtgg gaaaagggaa gagaactgag ggggggggga ataaataagt     2400

aaataacaaa ataaaactca tggattaaga aaaagacttt gtactggaat ggatgagaag     2460

aataatagta atgataataa tatgtcactc tgaaagtaat gcctcttatt tctgtggaga     2520

ctacaaacat acaaagagca caacattcca tagagcaaat tctcagttac agaatgctat     2580

tttttttttc aacacagtca aaatcattaa tttttttttg cctgcaatgg acaagagctt     2640

tgaagctgtt ctcgtaaaaa tctgtactag cagaagtgac ctgcaatcac tactgctgaa     2700

atgcacaacc caccacatca ttgtgctcac attcactgtt tggtttctgt aaatgtacag     2760

gaattgtctg aaattagata tgattttttt tttctccatg aaggaattca attacacacc     2820

tttgcctcat gcacttcttt gtcatttttg tcagactgct tctctcctgc aatttgtctc     2880

atggcaacaa aatataatgg agttctgctg ggaacttccc tactgccata ccactatcat     2940

ctgcctctga cattttggac aaatgtaata aaataggagg tattactttc agagcagacc     3000

ttgtatgtat ttacaaaaca agtggtacac aaaaaaaatt gttcatccca ccaaccaatg     3060

cccatcctgt ccctgaatag tagctgtccc ccacagcctt gaccagttta ggtcaacagt     3120

tctgcttctg tcccctccca gctccttgta acccctcagc cccccttgct ggcaggacag     3180

tatgagaagc tgaaaaacta gaatgtccta gttctttgca gtgctgctaa tcaacaacca     3240

aaacagtggt gtgttaccaa tattgttgat atcacagcat cataccatta tgaaggaagt     3300

aacccagcca aaatcaggtc agcttgctaa caagagaact gtgcataagt ttaagatgtg     3360

tgtgttcctc agtaccttaa aaaataagta gtaacgttca aatgagtaga agagtagaac     3420

tgagcttaaa acatctgtca gacaacagtg aaccaaccat ctttctagaa gatctcctac     3480

aatattctca gctgccatgg aaaatcgatg ttcttctttt attctctcaa gattttcagg     3540

ctgtatatta aaacttatat taagaactat gctaaccacc tcatcaggaa ccgttgtagg     3600

tggcgtgggt tttcttggca atcgactctc atgaaaacta cgagctaaat attcaatatg     3660

ttcctcttga ccaactttat tctgcatttt ttttgaacga ggtttagagc aagcttcagg     3720

aaactgagac aggaatttta ttaaaaattt aaattttgaa gaaagttcag ggttaatagc     3780

atccattttt tgctttgcaa gttcctcagc attcttaaca aaagacgtct cttttgacat     3840

gtttaaagtt taaacctcct gtgtgaaatt attatccgct cataattcca cacattatac     3900

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     3960

ttgcgttgcg ctcactgcca attgctttcc agtcgggaaa cctgtcgtgc cagctgcatt     4020

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4080

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4140

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4200

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4260

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4320

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4380

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4440

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4500

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4560

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4620

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4680

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     4740

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     4800

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     4860

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     4920

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     4980

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5040

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5100

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5160

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5220

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5280

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5340

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5400

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5460

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5520

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5580

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5640

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     5700

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     5760

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     5820

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     5880

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     5940

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6000

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6060

c                                                                     6061


<210>  54
<211>  6929
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAGG-Neo-IRES-GFP

<400>  54
tcgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtcgaggt gagccccacg ttctgcttca ctctccccat      420

ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat tttgtgcagc      480

gatgggggcg gggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

ggggagtcgc tgcgacgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc      720

ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct      780

cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct gtggctgcgt      840

gaaagccttg aggggctccg ggagggccct ttgtgcgggg ggagcggctc ggggggtgcg      900

tgcgtgtgtg tgtgcgtggg gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag      960

cgctgcgggc gcggcgcggg gctttgtgcg ctccgcagtg tgcgcgaggg gagcgcggcc     1020

gggggcggtg ccccgcggtg cggggggggc tgcgagggga acaaaggctg cgtgcggggt     1080

gtgtgcgtgg gggggtgagc agggggtgtg ggcgcgtcgg tcgggctgca accccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc aggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag     1680

ctcctgggca acgtgctggt tattgtgctg tctcatcatt ttggcaaaga attgatggga     1740

tcggccattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     1800

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     1860

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     1920

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     1980

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     2040

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     2100

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     2160

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     2220

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc     2280

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     2340

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     2400

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     2460

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     2520

cttgacgagt tcttctgatc tagcctccgc ccctctccct cccccccccc taacgttact     2580

ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata     2640

ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt     2700

cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa     2760

gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag     2820

cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca     2880

cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc     2940

aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat     3000

tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta     3060

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga     3120

taatatggcc acaaccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat     3180

cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga     3240

gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc     3300

cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta     3360

ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca     3420

ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt     3480

cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg     3540

caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc     3600

cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg     3660

cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct     3720

gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa     3780

gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga     3840

cgagctgtac aagtaaagcg gccgccaatt cactcctcag gtgcaggctg cctatcagaa     3900

ggtggtggct ggtgtggcca atgccctggc tcacaaatac cactgagatc tttttccctc     3960

tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag     4020

gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac     4080

atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac     4140

atatgcccat atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat     4200

gaaacagccc cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat     4260

tttttttata ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca     4320

tgttttacta gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct     4380

tctcttatgg agatccctcg acctgcagcc caagcttggc gtaatcatgg tcatagctgt     4440

ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa     4500

agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac     4560

tgcccgcttt ccagtcggga aacctgtcgt gccagcggat ccgcatctca attagtcagc     4620

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     4680

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc     4740

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa     4800

gctaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     4860

acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta     4920

tcttatcatg tctggatccg ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     4980

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     5040

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     5100

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5160

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5220

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5280

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     5340

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     5400

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     5460

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     5520

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     5580

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     5640

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     5700

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     5760

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     5820

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     5880

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     5940

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     6000

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     6060

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     6120

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     6180

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     6240

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     6300

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     6360

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     6420

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     6480

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     6540

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     6600

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     6660

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     6720

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     6780

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt     6840

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     6900

gcacatttcc ccgaaaagtg ccacctggg                                       6929


<210>  55
<211>  10461
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Targeting Vector

<400>  55
gcccctgcag ccgaattata ttatttttgc caaataattt ttaacaaaag ctctgaagtc       60

ttcttcattt aaattcttag atgatacttc atctggaaaa ttgtcccaat tagtagcatc      120

acgctgtgag taagttctaa accatttttt tattgttgta ttatctctaa tcttactact      180

cgatgagttt tcggtattat ctctattttt aacttggagc aggttccatt cattgttttt      240

ttcatcatag tgaataaaat caactgcttt aacacttgtg cctgaacacc atatccatcc      300

ggcgtaatac gactcactat agggagagcg gccgccagat cttccggatg gctcgagttt      360

ttcagcaaga tttttgaatg aagggcctga gggtgggcag tctgtctatc atgtacatct      420

ccatattctg ggaggtcgtc agttgggctg gcctcctggc taagattttt gcaccacaag      480

agatgctgca tgtgtacaaa tcactagcaa atagatttgt ttcccatcaa cttagccact      540

gttaatgtaa attgttcttg gatatgtgtc tttggagggc aataaatgct ctgaacagca      600

cttgcacaat aaagatacag catgtgggaa tgatctgtct catgtgtctt actgatggta      660

ttggttctgt aagataaaat attgtgtctg ggatgtgttt ggctctacta ttaatggtgc      720

tctattgatt gtgatttgtc atttgaaacc tgaggatgcg actgtatagc agtctttcat      780

gcatttttgg aaaaaaactt aagctttttg aaagctgctg ctacaacttt ttgtattgtt      840

ataaagtttt gtattgtttt tttaattgtg aaattataaa gatgccgtgc agggactgtt      900

tgaagcaaag tgcattgttt tagaaaccta caactctagt tcaagcactc catcagtatc      960

tgcttaatct ttgtcatcct ttgctatgag aaaatattaa gcagtagtct aaaggtacta     1020

tgaaactata acatagctga cattgtattt ataactacgt catgattttg atagaattga     1080

ggacttgaaa atgttaaact attcatgtag ggcctcttaa gatgcttaag ttgtttagta     1140

atgtaagtgt gcatttaatt gagattttat tgggcataat ttgtccatca gtatgacact     1200

ccttgtcagt gttgccttat acttgatgtt gttaccggat ctctgcaagg cagttattct     1260

tgaattaggc tcattgaagt gtctgccagt ataaatatat agcaactgtt ctttgtgtta     1320

aaattgagaa gctaaccagt ttttagtgct tctgactgtt ggaattcttt aagcagatgc     1380

cataagaaaa ttgtatttgt gatcaccact tctccagagt ggttttaaca ccaagggcat     1440

tagagaaaga aaggcaggcg tgtagagaat agtggacaga caaaagctgt gagttacgtt     1500

atgtttttca gctgaaaagc tgtgtttggt aaaagcatat gaaatcactc aacttggaag     1560

cattctctta gttctctgat agttctgagc agcagaactc ttcacctaag aggttacttc     1620

aactggaaga ctacctagtg cttctgatgg caactatatt taagatgaga ataagaggtg     1680

tttccagtgt ggtagcctca catctgttgc agtggttacc gttcgtcctc ctccgaggga     1740

cacagcttgg ccattcactg tggtgacacc aatatgatga tcagcaaatg gtgtttattc     1800

actactaaac acagcttata tacattttta cctacaaaat cgtgctgtca tgtcccactc     1860

tgattggttc acacatttcc ccgaaaagtg ccacctgggt cgacattgat tattgactag     1920

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt     1980

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac     2040

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg     2100

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag     2160

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat     2220

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat     2280

ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc     2340

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg     2400

ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg     2460

tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg     2520

gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg gggagtcgct gcgacgctgc     2580

cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc     2640

gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc     2700

ttggtttaat gacggcttgt ttcttttctg tggctgcgtg aaagccttga ggggctccgg     2760

gagggccctt tgtgcggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     2820

agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg     2880

ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc     2940

ggggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca     3000

gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc acccccctcc ccgagttgct     3060

gagcacggcc cggcttcggg tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg     3120

ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg     3180

gagggctcgg gggaggggcg cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg     3240

agccgcagcc attgcctttt atggtaatcg tgcgagaggg cgcagggact tcctttgtcc     3300

caaatctgtg cggagccgaa atctgggagg cgccgccgca ccccctctag cgggcgcggg     3360

gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg agggccttcg tgcgtcgccg     3420

cgccgccgtc cccttctccc tctccagcct cggggctgtc cgcgggggga cggctgcctt     3480

cgggggggac ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc     3540

tctgctaacc atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt     3600

attgtgctgt ctcatcattt tggcaaagaa ttgatgggat cggccattga acaagatgga     3660

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     3720

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     3780

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg     3840

ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     3900

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     3960

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     4020

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     4080

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     4140

ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg     4200

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     4260

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     4320

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     4380

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgatct     4440

agcctccgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa     4500

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg     4560

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc     4620

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct     4680

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac     4740

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc     4800

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta     4860

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg     4920

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg     4980

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggt     5040

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga     5100

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa     5160

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt     5220

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca     5280

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     5340

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     5400

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     5460

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat     5520

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca     5580

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     5640

gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     5700

ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca agtaaagcgg     5760

ccgccaattc actcctcagg tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa     5820

tgccctggct cacaaatacc actgagatct ttttccctct gccaaaaatt atggggacat     5880

catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt tcattgcaat     5940

agtgtgttgg aattttttgt gtctctcact cggaaggaca tatgggaggg caaatcattt     6000

aaaacatcag aatgagtatt tggtttagag tttggcaaca tatgcccata tgctggctgc     6060

catgaacaaa ggttggctat aaagaggtca tcagtatatg aaacagcccc ctgctgtcca     6120

ttccttattc catagaaaag ccttgacttg aggttagatt ttttttatat tttgttttgt     6180

gttatttttt tctttaacat ccctaaaatt ttccttacat gttttactag ccagattttt     6240

cctcctctcc tgactactcc cagtcatagc tgtccctctt ctcttatgga gatcgccgtt     6300

tccacattct tttctcatcc ttcttctcct gttttctctg catcaaggtc agcacgatag     6360

cactgtctct ctatgcttag ggagaggcct gtcctgtaca tcccgtgccc ccacaagatg     6420

cctactacaa caacatcttc tgcatgtcct gcatagcagt gttgggagaa tgtgcactac     6480

ttccactctt ctgatttcta ttttatgtgt ttgctttata ccagtgttgc catttgggaa     6540

ttaatacatg gttgatcaaa tcaattgcat cacagctgta tcctgtatca gaggaacatt     6600

atcaaagctt ttgttgctgt atttggtatc tgacctgcag ataaacatgt tttaggaagg     6660

ttttgcaaaa gtagctgtga aatgagctgg tgttgtgatt taacctgaca ggcagctaaa     6720

cagtatacca cagagctatt cacctacttt ccctcagtgg gaaaagggaa gagaactgag     6780

ggggggggga ataaataagt aaataacaaa ataaaactca tggattaaga aaaagacttt     6840

gtactggaat ggatgagaag aataatagta atgataataa tatgtcactc tgaaagtaat     6900

gcctcttatt tctgtggaga ctacaaacat acaaagagca caacattcca tagagcaaat     6960

tctcagttac agaatgctat tttttttttc aacacagtca aaatcattaa tttttttttg     7020

cctgcaatgg acaagagctt tgaagctgtt ctcgtaaaaa tctgtactag cagaagtgac     7080

ctgcaatcac tactgctgaa atgcacaacc caccacatca ttgtgctcac attcactgtt     7140

tggtttctgt aaatgtacag gaattgtctg aaattagata tgattttttt tttctccatg     7200

aaggaattca attacacacc tttgcctcat gcacttcttt gtcatttttg tcagactgct     7260

tctctcctgc aatttgtctc atggcaacaa aatataatgg agttctgctg ggaacttccc     7320

tactgccata ccactatcat ctgcctctga cattttggac aaatgtaata aaataggagg     7380

tattactttc agagcagacc ttgtatgtat ttacaaaaca agtggtacac aaaaaaaatt     7440

gttcatccca ccaaccaatg cccatcctgt ccctgaatag tagctgtccc ccacagcctt     7500

gaccagttta ggtcaacagt tctgcttctg tcccctccca gctccttgta acccctcagc     7560

cccccttgct ggcaggacag tatgagaagc tgaaaaacta gaatgtccta gttctttgca     7620

gtgctgctaa tcaacaacca aaacagtggt gtgttaccaa tattgttgat atcacagcat     7680

cataccatta tgaaggaagt aacccagcca aaatcaggtc agcttgctaa caagagaact     7740

gtgcataagt ttaagatgtg tgtgttcctc agtaccttaa aaaataagta gtaacgttca     7800

aatgagtaga agagtagaac tgagcttaaa acatctgtca gacaacagtg aaccaaccat     7860

ctttctagaa gatctcctac aatattctca gctgccatgg aaaatcgatg ttcttctttt     7920

attctctcaa gattttcagg ctgtatatta aaacttatat taagaactat gctaaccacc     7980

tcatcaggaa ccgttgtagg tggcgtgggt tttcttggca atcgactctc atgaaaacta     8040

cgagctaaat attcaatatg ttcctcttga ccaactttat tctgcatttt ttttgaacga     8100

ggtttagagc aagcttcagg aaactgagac aggaatttta ttaaaaattt aaattttgaa     8160

gaaagttcag ggttaatagc atccattttt tgctttgcaa gttcctcagc attcttaaca     8220

aaagacgtct cttttgacat gtttaaagtt taaacctcct gtgtgaaatt attatccgct     8280

cataattcca cacattatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg     8340

agtgagctaa ctcacattaa ttgcgttgcg ctcactgcca attgctttcc agtcgggaaa     8400

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     8460

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     8520

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     8580

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     8640

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     8700

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     8760

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     8820

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     8880

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     8940

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     9000

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     9060

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa     9120

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     9180

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     9240

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     9300

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     9360

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     9420

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     9480

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     9540

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     9600

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     9660

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     9720

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     9780

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     9840

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     9900

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     9960

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc    10020

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa    10080

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta    10140

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg    10200

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg    10260

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat    10320

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt    10380

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa    10440

aaataggcgt atcacgaggc c                                              10461


<210>  56
<211>  7679
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pmCherry-Cry2-CreN

<400>  56
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagcgcta      600

ccggtcgcca ccatggtgag caagggcgag gaggataaca tggccatcat caaggagttc      660

atgcgcttca aggtgcacat ggagggctcc gtgaacggcc acgagttcga gatcgagggc      720

gagggcgagg gccgccccta cgagggcacc cagaccgcca agctgaaggt gaccaagggt      780

ggccccctgc ccttcgcctg ggacatcctg tcccctcagt tcatgtacgg ctccaaggcc      840

tacgtgaagc accccgccga catccccgac tacttgaagc tgtccttccc cgagggcttc      900

aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc      960

tccctgcagg acggcgagtt catctacaag gtgaagctgc gcggcaccaa cttcccctcc     1020

gacggccccg taatgcagaa gaagaccatg ggctgggagg cctcctccga gcggatgtac     1080

cccgaggacg gcgccctgaa gggcgagatc aagcagaggc tgaagctgaa ggacggcggc     1140

cactacgacg ctgaggtcaa gaccacctac aaggccaaga agcccgtgca gctgcccggc     1200

gcctacaacg tcaacatcaa gttggacatc acctcccaca acgaggacta caccatcgtg     1260

gaacagtacg aacgcgccga gggccgccac tccaccggcg gcatggacga gctgtacaag     1320

tgtggcggct agtactccgg tattgcggta cccttgtacg cctgttttat actcccttcc     1380

cgtaacttag acgcacaaaa ccaagttcaa tagaaggggg tacaaaccag taccaccacg     1440

aacaagcact tctgtttccc cggtgatgtc gtatagactg cttgcgtggt tgaaagcgac     1500

ggatccgtta tccgcttatg tacttcgaga agcccagtac cacctcggaa tcttcgatgc     1560

gttgcgctca gcactcaacc ccagagtgta gcttaggctg atgagtctgg acatccctca     1620

ccggtgacgg tggtccaggc tgcgttggcg gcctacctat ggctaacgcc atgggacgct     1680

agttgtgaac aaggtgtgaa gagcctattg agctacataa gaatcctccg gcccctgaat     1740

gcggctaatc ccaacctcgg agcaggtggt cacaaaccag tgattggcct gtcgtaacgc     1800

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttccttttat tttattgtgg     1860

ctgcttatgg tgacaatcac agattgttat cataaagcga attggatagg atcaagctta     1920

tcgataccgt cgacctcgag ctcgccacca tgaagatgga caaaaagact atagtttggt     1980

ttagaagaga cctaaggatt gaggataatc ctgcattagc agcagctgct cacgaaggat     2040

ctgtttttcc tgtcttcatt tggtgtcctg aagaagaagg acagttttat cctggaagag     2100

cttcaagatg gtggatgaaa caatcacttg ctcacttatc tcaatccttg aaggctcttg     2160

gatctgacct cactttaatc aaaacccaca acacgatttc agcgatcttg gattgtatcc     2220

gcgttaccgg tgctacaaaa gtcgtcttta accacctcta tgatcctgtt tcgttagttc     2280

gggaccatac cgtaaaggag aagctggtgg aacgtgggat ctctgtgcaa agctacaatg     2340

gagatctatt gtatgaaccg tgggagatat actgcgaaaa gggcaaacct tttacgagtt     2400

tcaattctta ctggaagaaa tgcttagata tgtcgattga atccgttatg cttcctcctc     2460

cttggcggtt gatgccaata actgcagcgg ctgaagcgat ttgggcgtgt tcgattgaag     2520

aactagggct ggagaatgag gccgagaaac cgagcaatgc gttgttaact agagcttggt     2580

ctccaggatg gagcaatgct gataagttac taaatgagtt catcgagaag cagttgatag     2640

attatgcaaa gaacagcaag aaagttgttg ggaattctac ttcactactt tctccgtatc     2700

tccatttcgg ggaaataagc gtcagacacg ttttccagtg tgcccggatg aaacaaatta     2760

tatgggcaag agataagaac agtgaaggag aagaaagtgc agatcttttt cttaggggaa     2820

tcggtttaag agagtattct cggtatatat gtttcaactt cccgtttact cacgagcaat     2880

cgttgttgag tcatcttcgg tttttccctt gggatgctga tgttgataag ttcaaggcct     2940

ggagacaagg caggaccggt tatccgttgg tggatgccgg aatgagagag ctttgggcta     3000

ccggatggat gcataacaga ataagagtga ttgtttcaag ctttgctgtg aagtttcttc     3060

tccttccatg gaaatgggga atgaagtatt tctgggatac acttttggat gctgatttgg     3120

aatgtgacat ccttggctgg cagtatatct ctgggagtat ccccgatggc cacgagcttg     3180

atcgcttgga caatcccgcg ttacaaggcg ccaaatatga cccagaaggt gagtacataa     3240

ggcaatggct tcccgagctt gcgagattgc caactgaatg gatccatcat ccatgggacg     3300

ctcctttaac cgtactcaaa gcttctggtg tggaactcgg aacaaactat gcgaaaccca     3360

ttgtagacat cgacacagct cgtgagctac tagctaaagc tatttcaaga acccgtgaag     3420

cacagatcat gatcggagca gcacctgatg agattgtagc agatagcttc gaggccttag     3480

gggctaatac cattaaagaa cctggtcttt gcccatctgt gtcttctaat gaccaacaag     3540

taccttcggc tgttcgttac aacgggtcaa agagagtgaa acctgaggaa gaagaagaga     3600

gagacatgaa gaaatctagg ggattcgatg aaagggagtt gttttcgact gctgaatctt     3660

cttcttcttc gagtgtgttt ttcgtttcgc agtcttgctc gttggcatca gaagggaaga     3720

atctggaagg tattcaagat tcatctgatc agattactac aagtttggga aaaaatggtt     3780

gcaaaggtgg cggtggctct ggaggtggtg ggtccggagg aggcggccgc acgagtgatg     3840

aggttcgcaa gaacctgatg gacatgttca gggatcgcca ggcgttttct gagcatacct     3900

ggaaaatgct tctgtccgtt tgccggtcgt gggcggcatg gtgcaagttg aataaccgga     3960

aatggtttcc cgcagaacct gaagatgttc gcgattatct tctatatctt caggcgcgcg     4020

gtctggcagt aaaaactatc cagcaacatt tgggccagct aaacatgctt catcgtcggt     4080

ccgggctgta acccgggatc caccggatct agataactga tcataatcag ccataccaca     4140

tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat     4200

aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa     4260

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     4320

ttgtccaaac tcatcaatgt atcttaacgc gtaaattgta agcgttaata ttttgttaaa     4380

attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg aaatcggcaa     4440

aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc cagtttggaa     4500

caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca     4560

gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt cgaggtgccg     4620

taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac ggggaaagcc     4680

ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta gggcgctggc     4740

aagtgtagcg gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca     4800

gggcgcgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt     4860

ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata     4920

atattgaaaa aggaagagtc ctgaggcgga aagaaccagc tgtggaatgt gtgtcagtta     4980

gggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5040

tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc     5100

atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta     5160

actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca     5220

gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga     5280

ggcctaggct tttgcaaaga tcgatcaaga gacaggatga ggatcgtttc gcatgattga     5340

acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga     5400

ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg     5460

gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga     5520

ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt     5580

tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct     5640

gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct     5700

gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg     5760

agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca     5820

ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg agcatgcccg acggcgagga     5880

tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt     5940

ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt     6000

ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct     6060

ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt     6120

cttctgagcg ggactctggg gttcgaaatg accgaccaag cgacgcccaa cctgccatca     6180

cgagatttcg attccaccgc cgccttctat gaaaggttgg gcttcggaat cgttttccgg     6240

gacgccggct ggatgatcct ccagcgcggg gatctcatgc tggagttctt cgcccaccct     6300

agggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg cgctatgacg     6360

gcaataaaaa gacagaataa aacgcacggt gttgggtcgt ttgttcataa acgcggggtt     6420

cggtcccagg gctggcactc tgtcgatacc ccaccgagac cccattgggg ccaatacgcc     6480

cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca     6540

gccaacgtcg gggcggcagg ccctgccata gcctcaggtt actcatatat actttagatt     6600

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     6660

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     6720

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     6780

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     6840

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     6900

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6960

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     7020

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     7080

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     7140

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     7200

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     7260

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     7320

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     7380

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc catgcattag     7440

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     7500

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     7560

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     7620

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggac      7679


<210>  57
<211>  6655
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pmCherry-CIBN-CreC


<220>
<221>  misc_feature
<222>  (1717)..(1717)
<223>  n is a, c, g, or t

<400>  57
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagcgcta      600

ccggtcgcca ccatggtgag caagggcgag gaggataaca tggccatcat caaggagttc      660

atgcgcttca aggtgcacat ggagggctcc gtgaacggcc acgagttcga gatcgagggc      720

gagggcgagg gccgccccta cgagggcacc cagaccgcca agctgaaggt gaccaagggt      780

ggccccctgc ccttcgcctg ggacatcctg tcccctcagt tcatgtacgg ctccaaggcc      840

tacgtgaagc accccgccga catccccgac tacttgaagc tgtccttccc cgagggcttc      900

aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc      960

tccctgcagg acggcgagtt catctacaag gtgaagctgc gcggcaccaa cttcccctcc     1020

gacggccccg taatgcagaa gaagaccatg ggctgggagg cctcctccga gcggatgtac     1080

cccgaggacg gcgccctgaa gggcgagatc aagcagaggc tgaagctgaa ggacggcggc     1140

cactacgacg ctgaggtcaa gaccacctac aaggccaaga agcccgtgca gctgcccggc     1200

gcctacaacg tcaacatcaa gttggacatc acctcccaca acgaggacta caccatcgtg     1260

gaacagtacg aacgcgccga gggccgccac tccaccggcg gcatggacga gctgtacaag     1320

tgtggcggct agtactccgg tattgcggta cccttgtacg cctgttttat actcccttcc     1380

cgtaacttag acgcacaaaa ccaagttcaa tagaaggggg tacaaaccag taccaccacg     1440

aacaagcact tctgtttccc cggtgatgtc gtatagactg cttgcgtggt tgaaagcgac     1500

ggatccgtta tccgcttatg tacttcgaga agcccagtac cacctcggaa tcttcgatgc     1560

gttgcgctca gcactcaacc ccagagtgta gcttaggctg atgagtctgg acatccctca     1620

ccggtgacgg tggtccaggc tgcgttggcg gcctacctat ggctaacgcc atgggacgct     1680

agttgtgaac aaggtgtgaa gagcctattg agctacntaa gaatcctccg gcccctgaat     1740

gcggctaatc ccaacctcgg agcaggtggt cacaaaccag tgattggcct gtcgtaacgc     1800

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttccttttat tttattgtgg     1860

ctgcttatgg tgacaatcac agattgttat cataaagcga attggatagg atcaagctta     1920

tcgataccgt cgacctcgag ctcgccacca tgaatggagc tataggaggt gaccttttgc     1980

tcaattttcc tgacatgtcg gtcctagagc gccaaagggc tcacctcaag tacctcaatc     2040

ccacctttga ttctcctctc gccggcttct ttgccgattc ttcaatgatt accggcggcg     2100

agatggacag ctatctttcg actgccggtt tgaatcttcc gatgatgtac ggtgagacga     2160

cggtggaagg tgattcaaga ctctcaattt cgccggaaac gacgcttggg actggaaatt     2220

tcaagaaacg gaagtttgat acagagacta aggattgtaa tgagaagaag aagaagatga     2280

cgatgaacag agatgaccta gtagaagaag gagaagaaga gaagtcgaaa ataacagagc     2340

aaaacaatgg gagcacaaaa agcatcaaga agatgaaaca caaagccaag aaagaagaga     2400

acaatttctc taatgattca tctaaagtga cgaaggaatt ggagaaaacg gattatattc     2460

atggtggcgg tggctctgga ggtggtgggt ccggaggagg cggccgccga ccaagtgaca     2520

gcaatgctgt ttcactggtt atgcggcgga tccgaaaaga aaacgttgat gccggtgaac     2580

gtgcaaaaca ggctctagcg ttcgaacgca ctgatttcga ccaggttcgt tcactcatgg     2640

aaaatagcga tcgctgccag gatatacgta atctggcatt tctggggatt gcttataaca     2700

ccctgttacg tatagccgaa attgccagga tcagggttaa agatatctca cgtactgacg     2760

gtgggagaat gttaatccat attggcagaa cgaaaacgct ggttagcacc gcaggtgtag     2820

agaaggcact tagcctgggg gtaactaaac tggtcgagcg atggatttcc gtctctggtg     2880

tagctgatga tccgaataac tacctgtttt gccgggtcag aaaaaatggt gttgccgcgc     2940

catctgccac cagccagcta tcaactcgcg ccctggaagg gatttttgaa gcaactcatc     3000

gattgattta cggcgctaag gatgactctg gtcagagata cctggcctgg tctggacaca     3060

gtgcccgtgt cggagccgcg cgagatatgg cccgcgctgg agtttcaata ccggagatca     3120

tgcaagctgg tggctggacc aatgtaaata ttgtcatgaa ctatatccgt aacctggata     3180

gtgaaacagg ggcaatggtg cgcctgctgg aagatggcga ttagcccggg atccaccgga     3240

tctagataac tgatcataat cagccatacc acatttgtag aggttttact tgctttaaaa     3300

aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac     3360

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat     3420

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttaa     3480

cgcgtaaatt gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag     3540

ctcatttttt aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac     3600

cgagataggg ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga     3660

ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc     3720

accctaatca agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg     3780

gagcccccga tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa     3840

gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac     3900

caccacaccc gccgcgctta atgcgccgct acagggcgcg tcaggtggca cttttcgggg     3960

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     4020

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtcctgaggc     4080

ggaaagaacc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     4140

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     4200

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     4260

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     4320

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     4380

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa agatcgatca     4440

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     4500

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     4560

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     4620

cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac     4680

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     4740

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     4800

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     4860

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     4920

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     4980

caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     5040

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     5100

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     5160

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     5220

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct ggggttcgaa     5280

atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac cgccgccttc     5340

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     5400

ggggatctca tgctggagtt cttcgcccac cctaggggga ggctaactga aacacggaag     5460

gagacaatac cggaaggaac ccgcgctatg acggcaataa aaagacagaa taaaacgcac     5520

ggtgttgggt cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat     5580

accccaccga gaccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac     5640

cccccaagtt cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc     5700

atagcctcag gttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     5760

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     5820

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     5880

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     5940

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     6000

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     6060

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     6120

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     6180

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     6240

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     6300

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     6360

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     6420

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     6480

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     6540

tctgtggata accgtattac cgccatgcat tagcaccgcc tacatacctc gctctgctaa     6600

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttgga          6655


<210>  58
<211>  8968
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pB-RAGE-GFP

<400>  58
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagct cggaattaac cctcactaaa gggaacaaaa gctggctcgc gcgacttggt     2220

ttgccattct ttagcgcgcg tcgcgtcaca cagcttggcc acaatgtggt ttttgtcaaa     2280

cgaagattct atgacgtgtt taaagtttag gtcgagtaaa gcgcaaatct tttttaaccc     2340

tagaaagata gtctgcgtaa aattgacgca tgcattcttg aaatattgct ctctctttct     2400

aaatagcgcg aatccgtcgc tgtgcattta ggacatctca gtcgccgctt ggagctcccg     2460

tgaggcgtgc ttgtcaatgc ggtaagtgtc actgattttg aactataacg accgcgtgag     2520

tcaaaatgac gcatgattat cttttacgtg acttttaaga tttaactcat acgataatta     2580

tattgttatt tcatgttcta cttacgtgat aacttattat atatatattt tcttgttata     2640

gatatcgtga ctaatatata ataaaatggg tagttcttta gacgatgagc atatcctctc     2700

tgctcttctg caaagcgatg acgagcttgt tggctagtta ttaatagtaa tcaattacgg     2760

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     2820

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     2880

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     2940

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     3000

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     3060

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc cccacgttct     3120

gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta tttatttttt     3180

aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg     3240

ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg     3300

gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc tataaaaagc     3360

gaagcgcgcg gcgggcgggg agtcgctgcg acgctgcctt cgccccgtgc cccgctccgc     3420

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg     3480

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc     3540

ttttctgtgg ctgcgtgaaa gccttgaggg gctccgggag ggccctttgt gcggggggag     3600

cggctcgggg ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct     3660

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg     3720

cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa     3780

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg     3840

gctgcaaccc cccctgcacc cccctccccg agttgctgag cacggcccgg cttcgggtgc     3900

ggggctccgt acggggcgtg gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt     3960

gggggtgccg ggcggggcgg ggccgcctcg ggccggggag ggctcggggg aggggcgcgg     4020

cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     4080

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctgtgcgg agccgaaatc     4140

tgggaggcgc cgccgcaccc cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag     4200

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct     4260

ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg     4320

gttcggcttc tggcgtgtga ccggcggctc tagagcctct gctaaccatg ttcatgcctt     4380

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     4440

caaagaattc catcaagctt aggatccgga acccttaata taacttcgta taatgtatgc     4500

tatacgaagt tattaggtcc ctcgacctgc agcccaagct tacttaccat gtcagatcca     4560

gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa     4620

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     4680

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     4740

gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta tgatctctag     4800

tcaaggcact atacatcaaa tattccttat taaccccttt acaaattaaa aagctaaagg     4860

tacacaattt ttgagcatag ttattaatag cagacactct atgcctgtgt ggagtaagaa     4920

aaaacagtat gttatgatta taactgttat gcctacttat aaaggttaca gaatattttt     4980

ccataatttt cttgtatagc agtgcagctt tttcctttgt ggtgtaaata gcaaagcaag     5040

caagagttct attactaaac acagcatgac tcaaaaaact tagcaattct gaaggaaagt     5100

ccttggggtc ttctaccttt ctcttctttt ttggaggagt agaatgttga gagtcagcag     5160

tagcctcatc atcactagat ggcatttctt ctgagcaaaa caggttttcc tcattaaagg     5220

cattccacca ctgctcccat tcatcagttc cataggttgg aatctaaaat acacaaacaa     5280

ttagaatcag tagtttaaca cattatacac ttaaaaattt tatatttacc ttagagcttt     5340

aaatctctgt aggtagtttg tccaattatg tcacaccaca gaagtaaggt tccttcacaa     5400

agatccctcg agaaaaaaaa tataaaagag atggaggaac gggaaaaagt tagttgtggt     5460

gataggtggc aagtggtatt ccgtaagaac aacaagaaaa gcatttcata ttatggctga     5520

actgagcgaa caagtgcaaa atttaagcat caacgacaac aacgagaatg gttatgttcc     5580

tcctcactta agaggaaaac caagaagtgc cagaaataac atgagcaact acaataacaa     5640

caacggcggc tacaacggtg gccgtggcgg tggcagcttc tttagcaaca accgtcgtgg     5700

tggttacggc aacggtggtt tcttcggtgg aaacaacggt ggcagcagat ctaacggccg     5760

ttctggtggt agatggatcg atggcaaaca tgtcccagct ccaagaaacg aaaaggccga     5820

gatcgccata tttggtgtcc ccgaggatcc ggaaccctta atataacttc gtataatgta     5880

tgctatacga agttattagg tccctcgaag aggttcacta gggctagcat ggtgagcaag     5940

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac     6000

ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc     6060

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc     6120

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc     6180

ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac     6240

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc     6300

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac     6360

aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg     6420

aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag     6480

cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc     6540

cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc     6600

gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaaag cggccgccaa     6660

ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg ctggtgtggc caatgccctg     6720

gctcacaaat accactgaga tctttttccc tctgccaaaa attatgggga catcatgaag     6780

ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc aatagtgtgt     6840

tggaattttt tgtgtctctc actcggaagg acatatggga gggcaaatca tttaaaacat     6900

cagaatgagt atttggttta gagtttggca acatatgccc atatgctggc tgccatgaac     6960

aaaggttggc tataaagagg tcatcagtat atgaaacagc cccctgctgt ccattcctta     7020

ttccatagaa aagccttgac ttgaggttag atttttttta tattttgttt tgtgttattt     7080

ttttctttaa catccctaaa attttcctta catgttttac tagccagatt tttcctcctc     7140

tcctgactac tcccagtcat agctgtccct cttctcttat ggagatccct cgacctgcag     7200

cccaagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac     7260

aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt     7320

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc     7380

gtgccagcgg atccgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     7440

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     7500

tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga     7560

ggcttttttg gaggcctagg gccgctgatc agcctcgact gtgccttcta gttgccagcc     7620

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     7680

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     7740

ggggagtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     7800

tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg gcttaattaa     7860

cgagagcata atattgatat gtgccaaagt tgtttctgac tgactaataa gtataatttg     7920

tttctattat gtataggtta agctaattac ttattttata atacaacatg actgttttta     7980

aagtacaaaa taagtttatt tttgtaaaag agagaatgtt taaaagtttt gttactttat     8040

agaagaaatt ttgagttttt gttttttttt aataaataaa taaacataaa taaattgttt     8100

gttgaattta ttattagtat gtaagtgtaa atataataaa acttaatatc tattcaaatt     8160

aataaataaa cctcgatata cagaccgata aaacacatgc gtcaatttta cgcatgatta     8220

tctttaacgt acgtcacaat atgattatct ttctagggtt aaataatagt ttctaatttt     8280

tttattattc agcctgctgt cgtgaatacc gagctccaat tcgccctata gtgagtcgta     8340

ttacaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     8400

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     8460

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcg acgcgccctg     8520

tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc     8580

cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg     8640

ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg     8700

gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg     8760

atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt     8820

ccaaactgga acaacactca accctatctc ggtctattct tttgatttat aagggatttt     8880

gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt     8940

taacaaaata ttaacgttta caatttcc                                        8968


<210>  59
<211>  6188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAGG-IRES-GFP

<400>  59
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggttattgt gctgtctcat cattttggca aagaattcag cacctgcaca tgggacgtcg     1740

acctgaggta attataaccc gggccctata tatggatcgg ctagccgatc cgcccctctc     1800

cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgtttg     1860

tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg     1920

gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag     1980

gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt     2040

ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc     2100

aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga     2160

gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga     2220

aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct     2280

ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg     2340

ttttcctttg aaaaacacga tgataatatg gccacaacca tggtgagcaa gggcgaggag     2400

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     2460

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     2520

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac     2580

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     2640

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     2700

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     2760

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     2820

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     2880

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     2940

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     3000

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     3060

gccgggatca ctctcggcat ggacgagctg tacaagtaaa gcggccgcca attcactcct     3120

caggtgcagg ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa     3180

taccactgag atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     3240

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     3300

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag     3360

tatttggttt agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg     3420

ctataaagag gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga     3480

aaagccttga cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta     3540

acatccctaa aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta     3600

ctcccagtca tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctt     3660

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca     3720

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact     3780

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagcg     3840

gatccgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     3900

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     3960

gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt     4020

ggaggcctag gcttttgcaa aaagctaact tgtttattgc agcttataat ggttacaaat     4080

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     4140

gtttgtccaa actcatcaat gtatcttatc atgtctggat ccgctgcatt aatgaatcgg     4200

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     4260

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     4320

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     4380

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     4440

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     4500

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     4560

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     4620

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     4680

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     4740

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     4800

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     4860

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     4920

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     4980

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     5040

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     5100

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     5160

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     5220

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     5280

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     5340

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     5400

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     5460

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     5520

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     5580

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     5640

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     5700

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     5760

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     5820

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     5880

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     5940

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     6000

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta     6060

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     6120

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg ggtcgacatt     6180

gattattg                                                              6188


<210>  60
<211>  9644
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAGG-Optogenes

<400>  60
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggttattgt gctgtctcat cattttggca aagaattcag cacctgcaca tgggacgtcg     1740

acctgaggta attataaccc cccgggatga atggagctat aggaggtgac cttttgctca     1800

attttcctga catgtcggtc ctagagcgcc aaagggctca cctcaagtac ctcaatccca     1860

cctttgattc tcctctcgcc ggcttctttg ccgattcttc aatgattacc ggcggcgaga     1920

tggacagcta tctttcgact gccggtttga atcttccgat gatgtacggt gagacgacgg     1980

tggaaggtga ttcaagactc tcaatttcgc cggaaacgac gcttgggact ggaaatttca     2040

agaaacggaa gtttgataca gagactaagg attgtaatga gaagaagaag aagatgacga     2100

tgaacagaga tgacctagta gaagaaggag aagaagagaa gtcgaaaata acagagcaaa     2160

acaatgggag cacaaaaagc atcaagaaga tgaaacacaa agccaagaaa gaagagaaca     2220

atttctctaa tgattcatct aaagtgacga aggaattgga gaaaacggat tatattcatg     2280

gtggcggtgg ctctggaggt ggtgggtccg gaggaggcgg ccgccgacca agtgacagca     2340

atgctgtttc actggttatg cggcggatcc gaaaagaaaa cgttgatgcc ggtgaacgtg     2400

caaaacaggc tctagcgttc gaacgcactg atttcgacca ggttcgttca ctcatggaaa     2460

atagcgatcg ctgccaggat atacgtaatc tggcatttct ggggattgct tataacaccc     2520

tgttacgtat agccgaaatt gccaggatca gggttaaaga tatctcacgt actgacggtg     2580

ggagaatgtt aatccatatt ggcagaacga aaacgctggt tagcaccgca ggtgtagaga     2640

aggcacttag cctgggggta actaaactgg tcgagcgatg gatttccgtc tctggtgtag     2700

ctgatgatcc gaataactac ctgttttgcc gggtcagaaa aaatggtgtt gccgcgccat     2760

ctgccaccag ccagctatca actcgcgccc tggaagggat ttttgaagca actcatcgat     2820

tgatttacgg cgctaaggat gactctggtc agagatacct ggcctggtct ggacacagtg     2880

cccgtgtcgg agccgcgcga gatatggccc gcgctggagt ttcaataccg gagatcatgc     2940

aagctggtgg ctggaccaat gtaaatattg tcatgaacta tatccgtaac ctggatagtg     3000

aaacaggggc aatggtgcgc ctgctggaag atggcgatgc cacgaacttc tctctgttaa     3060

agcaagcagg agacgtggaa gaaaaccccg gtcctatgaa gatggacaaa aagactatag     3120

tttggtttag aagagaccta aggattgagg ataatcctgc attagcagca gctgctcacg     3180

aaggatctgt ttttcctgtc ttcatttggt gtcctgaaga agaaggacag ttttatcctg     3240

gaagagcttc aagatggtgg atgaaacaat cacttgctca cttatctcaa tccttgaagg     3300

ctcttggatc tgacctcact ttaatcaaaa cccacaacac gatttcagcg atcttggatt     3360

gtatccgcgt taccggtgct acaaaagtcg tctttaacca cctctatgat cctgtttcgt     3420

tagttcggga ccataccgta aaggagaagc tggtggaacg tgggatctct gtgcaaagct     3480

acaatggaga tctattgtat gaaccgtggg agatatactg cgaaaagggc aaacctttta     3540

cgagtttcaa ttcttactgg aagaaatgct tagatatgtc gattgaatcc gttatgcttc     3600

ctcctccttg gcggttgatg ccaataactg cagcggctga agcgatttgg gcgtgttcga     3660

ttgaagaact agggctggag aatgaggccg agaaaccgag caatgcgttg ttaactagag     3720

cttggtctcc aggatggagc aatgctgata agttactaaa tgagttcatc gagaagcagt     3780

tgatagatta tgcaaagaac agcaagaaag ttgttgggaa ttctacttca ctactttctc     3840

cgtatctcca tttcggggaa ataagcgtca gacacgtttt ccagtgtgcc cggatgaaac     3900

aaattatatg ggcaagagat aagaacagtg aaggagaaga aagtgcagat ctttttctta     3960

ggggaatcgg tttaagagag tattctcggt atatatgttt caacttcccg tttactcacg     4020

agcaatcgtt gttgagtcat cttcggtttt tcccttggga tgctgatgtt gataagttca     4080

aggcctggag acaaggcagg accggttatc cgttggtgga tgccggaatg agagagcttt     4140

gggctaccgg atggatgcat aacagaataa gagtgattgt ttcaagcttt gctgtgaagt     4200

ttcttctcct tccatggaaa tggggaatga agtatttctg ggatacactt ttggatgctg     4260

atttggaatg tgacatcctt ggctggcagt atatctctgg gagtatcccc gatggccacg     4320

agcttgatcg cttggacaat cccgcgttac aaggcgccaa atatgaccca gaaggtgagt     4380

acataaggca atggcttccc gagcttgcga gattgccaac tgaatggatc catcatccat     4440

gggacgctcc tttaaccgta ctcaaagctt ctggtgtgga actcggaaca aactatgcga     4500

aacccattgt agacatcgac acagctcgtg agctactagc taaagctatt tcaagaaccc     4560

gtgaagcaca gatcatgatc ggagcagcac ctgatgagat tgtagcagat agcttcgagg     4620

ccttaggggc taataccatt aaagaacctg gtctttgccc atctgtgtct tctaatgacc     4680

aacaagtacc ttcggctgtt cgttacaacg ggtcaaagag agtgaaacct gaggaagaag     4740

aagagagaga catgaagaaa tctaggggat tcgatgaaag ggagttgttt tcgactgctg     4800

aatcttcttc ttcttcgagt gtgtttttcg tttcgcagtc ttgctcgttg gcatcagaag     4860

ggaagaatct ggaaggtatt caagattcat ctgatcagat tactacaagt ttgggaaaaa     4920

atggttgcaa aggtggcggt ggctctggag gtggtgggtc cggaggaggc ggccgcacga     4980

gtgatgaggt tcgcaagaac ctgatggaca tgttcaggga tcgccaggcg ttttctgagc     5040

atacctggaa aatgcttctg tccgtttgcc ggtcgtgggc ggcatggtgc aagttgaata     5100

accggaaatg gtttcccgca gaacctgaag atgttcgcga ttatcttcta tatcttcagg     5160

cgcgcggtct ggcagtaaaa actatccagc aacatttggg ccagctaaac atgcttcatc     5220

gtcggtccgg gctgtaagct agcctccgcc cctctccctc ccccccccct aacgttactg     5280

gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgttattt tccaccatat     5340

tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc     5400

ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag     5460

cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc     5520

ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac     5580

ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca     5640

aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt     5700

gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa     5760

aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgatgat     5820

aatatggcca caaccatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc     5880

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag     5940

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc     6000

gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac     6060

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag     6120

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc     6180

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc     6240

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc     6300

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc     6360

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg     6420

ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag     6480

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac     6540

gagctgtaca agtaaagcgg ccgccaattc actcctcagg tgcaggctgc ctatcagaag     6600

gtggtggctg gtgtggccaa tgccctggct cacaaatacc actgagatct ttttccctct     6660

gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg     6720

aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact cggaaggaca     6780

tatgggaggg caaatcattt aaaacatcag aatgagtatt tggtttagag tttggcaaca     6840

tatgcccata tgctggctgc catgaacaaa ggttggctat aaagaggtca tcagtatatg     6900

aaacagcccc ctgctgtcca ttccttattc catagaaaag ccttgacttg aggttagatt     6960

ttttttatat tttgttttgt gttatttttt tctttaacat ccctaaaatt ttccttacat     7020

gttttactag ccagattttt cctcctctcc tgactactcc cagtcatagc tgtccctctt     7080

ctcttatgga gatccctcga cctgcagccc aagcttggcg taatcatggt catagctgtt     7140

tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa     7200

gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact     7260

gcccgctttc cagtcgggaa acctgtcgtg ccagcggatc cgcatctcaa ttagtcagca     7320

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     7380

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc     7440

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     7500

ctaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7560

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7620

cttatcatgt ctggatccgc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     7680

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     7740

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     7800

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     7860

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     7920

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     7980

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     8040

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     8100

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     8160

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     8220

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     8280

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     8340

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     8400

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     8460

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     8520

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     8580

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     8640

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     8700

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     8760

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     8820

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     8880

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     8940

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     9000

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     9060

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     9120

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     9180

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     9240

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     9300

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     9360

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     9420

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     9480

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     9540

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     9600

cacatttccc cgaaaagtgc cacctgggtc gacattgatt attg                      9644


<210>  61
<211>  9166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pB-RAGE-mCherry

<400>  61
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagct cggaattaac cctcactaaa gggaacaaaa gctggctcgc gcgacttggt     2220

ttgccattct ttagcgcgcg tcgcgtcaca cagcttggcc acaatgtggt ttttgtcaaa     2280

cgaagattct atgacgtgtt taaagtttag gtcgagtaaa gcgcaaatct tttttaaccc     2340

tagaaagata gtctgcgtaa aattgacgca tgcattcttg aaatattgct ctctctttct     2400

aaatagcgcg aatccgtcgc tgtgcattta ggacatctca gtcgccgctt ggagctcccg     2460

tgaggcgtgc ttgtcaatgc ggtaagtgtc actgattttg aactataacg accgcgtgag     2520

tcaaaatgac gcatgattat cttttacgtg acttttaaga tttaactcat acgataatta     2580

tattgttatt tcatgttcta cttacgtgat aacttattat atatatattt tcttgttata     2640

gatatcgtga ctaatatata ataaaatggg tagttcttta gacgatgagc atatcctctc     2700

tgctcttctg caaagcgatg acgagcttgt tggctagtta ttaatagtaa tcaattacgg     2760

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     2820

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     2880

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     2940

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     3000

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     3060

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc cccacgttct     3120

gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta tttatttttt     3180

aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg     3240

ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg     3300

gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc tataaaaagc     3360

gaagcgcgcg gcgggcgggg agtcgctgcg acgctgcctt cgccccgtgc cccgctccgc     3420

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg     3480

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc     3540

ttttctgtgg ctgcgtgaaa gccttgaggg gctccgggag ggccctttgt gcggggggag     3600

cggctcgggg ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct     3660

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg     3720

cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa     3780

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg     3840

gctgcaaccc cccctgcacc cccctccccg agttgctgag cacggcccgg cttcgggtgc     3900

ggggctccgt acggggcgtg gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt     3960

gggggtgccg ggcggggcgg ggccgcctcg ggccggggag ggctcggggg aggggcgcgg     4020

cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     4080

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctgtgcgg agccgaaatc     4140

tgggaggcgc cgccgcaccc cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag     4200

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct     4260

ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg     4320

gttcggcttc tggcgtgtga ccggcggctc tagagcctct gctaaccatg ttcatgcctt     4380

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     4440

caaagaattc catcaagctt aggatccgga acccttaata taacttcgta taatgtatgc     4500

tatacgaagt tattaggtcc ctcgacctgc agcccaagct tacttaccat gtcagatcca     4560

gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa     4620

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     4680

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     4740

gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta tgatctctag     4800

tcaaggcact atacatcaaa tattccttat taaccccttt acaaattaaa aagctaaagg     4860

tacacaattt ttgagcatag ttattaatag cagacactct atgcctgtgt ggagtaagaa     4920

aaaacagtat gttatgatta taactgttat gcctacttat aaaggttaca gaatattttt     4980

ccataatttt cttgtatagc agtgcagctt tttcctttgt ggtgtaaata gcaaagcaag     5040

caagagttct attactaaac acagcatgac tcaaaaaact tagcaattct gaaggaaagt     5100

ccttggggtc ttctaccttt ctcttctttt ttggaggagt agaatgttga gagtcagcag     5160

tagcctcatc atcactagat ggcatttctt ctgagcaaaa caggttttcc tcattaaagg     5220

cattccacca ctgctcccat tcatcagttc cataggttgg aatctaaaat acacaaacaa     5280

ttagaatcag tagtttaaca cattatacac ttaaaaattt tatatttacc ttagagcttt     5340

aaatctctgt aggtagtttg tccaattatg tcacaccaca gaagtaaggt tccttcacaa     5400

agatccctcg agaaaaaaaa tataaaagag atggaggaac gggaaaaagt tagttgtggt     5460

gataggtggc aagtggtatt ccgtaagaac aacaagaaaa gcatttcata ttatggctga     5520

actgagcgaa caagtgcaaa atttaagcat caacgacaac aacgagaatg gttatgttcc     5580

tcctcactta agaggaaaac caagaagtgc cagaaataac atgagcaact acaataacaa     5640

caacggcggc tacaacggtg gccgtggcgg tggcagcttc tttagcaaca accgtcgtgg     5700

tggttacggc aacggtggtt tcttcggtgg aaacaacggt ggcagcagat ctaacggccg     5760

ttctggtggt agatggatcg atggcaaaca tgtcccagct ccaagaaacg aaaaggccga     5820

gatcgccata tttggtgtcc ccgaggatcc ggaaccctta atataacttc gtataatgta     5880

tgctatacga agttattagg tccctcgaag aggttcacta gggctagcag ttataggatc     5940

tccgccacca tgctgtgctg catcagaaga actaaaccgg ttgagaagaa tgaagaggcc     6000

gatcaggagc tgcagtcgac ggtaccgcgg gcccgggatc caccggtagc atccgccacc     6060

atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag     6120

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc     6180

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc     6240

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac     6300

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc     6360

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac     6420

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta     6480

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc     6540

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct     6600

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc     6660

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa     6720

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaaggg cagtggagag     6780

ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggccc aactagtgtt     6840

taaacgcggc cgcggcaatt cactcctcag gtgcaggctg cctatcagaa ggtggtggct     6900

ggtgtggcca atgccctggc tcacaaatac cactgagatc tttttccctc tgccaaaaat     6960

tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt     7020

ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg     7080

gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat     7140

atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc     7200

cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata     7260

ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta     7320

gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg     7380

agatccctcg acctgcagcc caagcttggc gtaatcatgg tcatagctgt ttcctgtgtg     7440

aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc     7500

ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt     7560

ccagtcggga aacctgtcgt gccagcggat ccgcatctca attagtcagc aaccatagtc     7620

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     7680

catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta     7740

ttccagaagt agtgaggagg cttttttgga ggcctagggc cgctgatcag cctcgactgt     7800

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     7860

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     7920

taggtgtcat tctattctgg ggagtggggt ggggcaggac agcaaggggg aggattggga     7980

agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac     8040

cagctggggc ttaattaacg agagcataat attgatatgt gccaaagttg tttctgactg     8100

actaataagt ataatttgtt tctattatgt ataggttaag ctaattactt attttataat     8160

acaacatgac tgtttttaaa gtacaaaata agtttatttt tgtaaaagag agaatgttta     8220

aaagttttgt tactttatag aagaaatttt gagtttttgt ttttttttaa taaataaata     8280

aacataaata aattgtttgt tgaatttatt attagtatgt aagtgtaaat ataataaaac     8340

ttaatatcta ttcaaattaa taaataaacc tcgatataca gaccgataaa acacatgcgt     8400

caattttacg catgattatc tttaacgtac gtcacaatat gattatcttt ctagggttaa     8460

ataatagttt ctaatttttt tattattcag cctgctgtcg tgaataccga gctccaattc     8520

gccctatagt gagtcgtatt acaattcact ggccgtcgtt ttacaacgtc gtgactggga     8580

aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg     8640

taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga     8700

atggcgcgac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     8760

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt     8820

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     8880

ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg     8940

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     9000

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt     9060

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca     9120

aaaatttaac gcgaatttta acaaaatatt aacgtttaca atttcc                    9166


<210>  62
<211>  4526
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pSK BS-PGK-DTA

<400>  62
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt       60

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa      120

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt      180

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt      240

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt      300

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg      360

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga      420

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa      480

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga      540

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa      600

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca      660

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta      720

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac      780

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc      840

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag      900

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga      960

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     1020

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     1080

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     1140

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     1200

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     1260

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     1320

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     1380

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     1440

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     1500

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     1560

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     1620

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     1680

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     1740

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     1800

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     1860

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     1920

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     1980

gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg     2040

tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt     2100

tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg     2160

ccaagcgcgc aattaaccct cactaaaggg aacaaaagct ggagctccac cgcggtggcg     2220

gccgctctag aactagtgga tccccaattc taccgggtag gggaggcgct tttcccaagg     2280

cagtctggag catgcgcttt agcagccccg ctgggcactt ggcgctacac aagtggcctc     2340

tggcctcgca cacattccac atccaccggt aggcgccaac cggctccgtt ctttggtggc     2400

cccttcgcgc caccttctac tcctccccta gtcaggaagt tcccccccgc cccgcagctc     2460

gcgtcgtgca ggacgtgaca aatggaagta gcacgtctca ctagtctcgt gcagatggac     2520

agcaccgctg agcaatggaa gcgggtaggc ctttggggca gcggccaata gcagctttgc     2580

tccttcgctt tctgggctca gaggctggga aggggtgggt ccgggggcgg gctcaggggc     2640

gggctcaggg gcggggcggg cgcccgaagg tcctccggag gcccggcatt ctgcacgctt     2700

caaaagcgca cgtctgccgc gctgttctcc tcttcctcat ctccgggcct ttcgacctgc     2760

aggtcctcgc catggatcct gatgatgttg ttgattcttc taaatctttt gtgatggaaa     2820

acttttcttc gtaccacggg actaaacctg gttatgtaga ttccattcaa aaaggtatac     2880

aaaagccaaa atctggtaca caaggaaatt atgacgatga ttggaaaggg ttttatagta     2940

ccgacaataa atacgacgct gcgggatact ctgtagataa tgaaaacccg ctctctggaa     3000

aagctggagg cgtggtcaaa gtgacgtatc caggactgac gaaggttctc gcactaaaag     3060

tggataatgc cgaaactatt aagaaagagt taggtttaag tctcactgaa ccgttgatgg     3120

agcaagtcgg aacggaagag tttatcaaaa ggttcggtga tggtgcttcg cgtgtagtgc     3180

tcagccttcc cttcgctgag gggagttcta gcgttgaata tattaataac tgggaacagg     3240

cgaaagcgtt aagcgtagaa cttgagatta attttgaaac ccgtggaaaa cgtggccaag     3300

atgcgatgta tgagtatatg gctcaagcct gtgcaggaaa tcgtgtcagg cgatctcttt     3360

gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa     3420

agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt     3480

gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgca     3540

gatcctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     3600

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     3660

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     3720

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     3780

gtgggctcta tggcttctga ggcggaaaga accagctggg gctcgagata tcaagcttat     3840

cgataccgtc gacctcgagg gggggcccgg tacccaattc gccctatagt gagtcgtatt     3900

acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc     3960

aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc     4020

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggaaa ttgtaagcgt     4080

taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata     4140

ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt     4200

tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg     4260

aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt     4320

ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc     4380

ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg     4440

cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct     4500

taatgcgccg ctacagggcg cgtcag                                          4526


<210>  63
<211>  4929
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGK-IRES-GFP

<400>  63
tcgacaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc       60

cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac      120

cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc      180

cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga      240

agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt      300

aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct      360

gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg      420

aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt      480

ctcctcttcc tcatctccgg gcctttcgac ctgccccggg ccctatatat ggatcggcta      540

gccgatccgc ccctctccct cccccccccc taacgttact ggccgaagcc gcttggaata      600

aggccggtgt gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt      660

gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct      720

cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc      780

ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga      840

caggtgcctc tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc      900

ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt      960

attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg     1020

gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc     1080

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg     1140

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     1200

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     1260

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     1320

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     1380

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     1440

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     1500

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     1560

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     1620

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     1680

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     1740

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     1800

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaagcg     1860

gccgccaatt cactcctcag gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca     1920

atgccctggc tcacaaatac cactgagatc tttttccctc tgccaaaaat tatggggaca     1980

tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa     2040

tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt     2100

taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat atgctggctg     2160

ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc cctgctgtcc     2220

attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata ttttgttttg     2280

tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta gccagatttt     2340

tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg agatccctcg     2400

acctgcagcc caagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     2460

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     2520

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     2580

aacctgtcgt gccagcggat ccgcatctca attagtcagc aaccatagtc ccgcccctaa     2640

ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc catggctgac     2700

taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt     2760

agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctaacttgt ttattgcagc     2820

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     2880

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatccg     2940

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     3000

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     3060

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3120

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3180

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3240

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3300

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3360

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3420

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3480

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3540

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3600

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3660

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3720

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3780

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     3840

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     3900

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     3960

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     4020

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     4080

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     4140

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     4200

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     4260

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     4320

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     4380

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     4440

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     4500

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     4560

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     4620

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     4680

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     4740

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     4800

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     4860

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     4920

ccacctggg                                                             4929


<210>  64
<211>  5568
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGK-DTA-IRES-GFP

<400>  64
tcgacaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc       60

cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac      120

cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc      180

cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga      240

agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt      300

aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct      360

gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg      420

aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt      480

ctcctcttcc tcatctccgg gcctttcgac ctgccccggg atggatcctg atgatgttgt      540

tgattcttct aaatcttttg tgatggaaaa cttttcttcg taccacggga ctaaacctgg      600

ttatgtagat tccattcaaa aaggtataca aaagccaaaa tctggtacac aaggaaatta      660

tgacgatgat tggaaagggt tttatagtac cgacaataaa tacgacgctg cgggatactc      720

tgtagataat gaaaacccgc tctctggaaa agctggaggc gtggtcaaag tgacgtatcc      780

aggactgacg aaggttctcg cactaaaagt ggataatgcc gaaactatta agaaagagtt      840

aggtttaagt ctcactgaac cgttgatgga gcaagtcgga acggaagagt ttatcaaaag      900

gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc ttcgctgagg ggagttctag      960

cgttgaatat attaataact gggaacaggc gaaagcgtta agcgtagaac ttgagattaa     1020

ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat gagtatatgg ctcaagcctg     1080

tgcaggaaat cgtgtcaggc gatctctttg tgaaggaacc ttacttctgt ggtgtgacat     1140

aattggacaa actacctaca gagatttaaa gctctaagct agcctccgcc cctctccctc     1200

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     1260

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     1320

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     1380

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     1440

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     1500

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     1560

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     1620

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca catgctttac     1680

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     1740

cctttgaaaa acacgatgat aatatggcca caaccatggt gagcaagggc gaggagctgt     1800

tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca     1860

gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct     1920

gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg     1980

tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca     2040

tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga     2100

cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca     2160

tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac tacaacagcc     2220

acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac ttcaagatcc     2280

gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca     2340

tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag tccgccctga     2400

gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg     2460

ggatcactct cggcatggac gagctgtaca agtaaagcgg ccgccaattc actcctcagg     2520

tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct cacaaatacc     2580

actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     2640

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     2700

gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt     2760

tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat     2820

aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag     2880

ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat     2940

ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc     3000

cagtcatagc tgtccctctt ctcttatgga gatccctcga cctgcagccc aagcttggcg     3060

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     3120

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     3180

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagcggatc     3240

cgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     3300

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     3360

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag     3420

gcctaggctt ttgcaaaaag ctaacttgtt tattgcagct tataatggtt acaaataaag     3480

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     3540

gtccaaactc atcaatgtat cttatcatgt ctggatccgc tgcattaatg aatcggccaa     3600

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     3660

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     3720

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     3780

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     3840

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     3900

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     3960

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4020

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4080

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4140

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4200

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4260

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     4320

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     4380

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     4440

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     4500

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     4560

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     4620

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     4680

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     4740

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     4800

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     4860

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     4920

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     4980

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     5040

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     5100

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     5160

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     5220

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     5280

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     5340

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     5400

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     5460

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     5520

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctggg                  5568


<210>  65
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Negative Mag recombinase

<400>  65
catactcttt atgcccccgg tggatatgac attatgggat atctggacca gatcggcaac       60

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt      120

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca      180

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc      240

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc      300

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga      360

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga      420

tactctatgg gattccagtg cgaaacagaa                                       450


<210>  66
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1

<400>  66
gccaaataag gcacgttatc                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 2

<400>  67
aatgtggaaa cggccaaata                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 3

<400>  68
accagataac gtgccttatt                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 4

<400>  69
acatgacagc acgattttgt                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 5

<400>  70
ctggtatgaa ccaatcagag                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 6

<400>  71
tggtatgaac caatcagagt                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 7

<400>  72
gaccttgatg cagagaaaac                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 8

<400>  73
ctcctgtttt ctctgcatca                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 9

<400>  74
gcagagaaaa caggagaaga                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 10

<400>  75
agaaggatga gaaaagaatg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 11

<400>  76
ctgtcatgtc ccactctgat                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 12

<400>  77
atgagaaaag aatgtggaaa                                                   20


<210>  78
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  78
ccaacagaag gcacgttatc cag                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  79
tcaaaataaa gtacgttatc tag                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  80
ggcatataaa gcacgttata cag                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  81
gcataataat gtacgttatc tgg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  82
actaaatcag gcacgtgatc tgg                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  83
gctaaattaa gctcgttatc ggg                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  84
gtcaaatgag gcatgttatc agg                                               23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  85
ttcaaataag ccacgttatt cag                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  86
gtcaaacaag gcatgttatc agg                                               23


<210>  87
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide 1 potential off target

<400>  87
ccctaataaa gcacgttttc agg                                               23


<210>  88
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FWD primer

<400>  88
accatcttcg ggaagattat cc                                                22


<210>  89
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  REV primer

<400>  89
cttctgcttc agataacctg ac                                                22


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GAPDH primers: Forward

<400>  90
actgtcaagg ctgagaacgg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GAPDH primers: Reverse

<400>  91
acctgcatct gcccatttga                                                   20


<210>  92
<211>  657
<212>  DNA
<213>  Corynebacterium diphtheriae

<400>  92
atggatcctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatctctttg tgaaggaacc      600

ttacttctgt ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaa         657


<210>  93
<211>  218
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  93

Met Asp Pro Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Leu Cys Glu Gly Thr Leu Leu Leu Trp Cys Asp Ile Ile 
        195                 200                 205             


Gly Gln Thr Thr Tyr Arg Asp Leu Lys Leu 
    210                 215             


<210>  94
<211>  852
<212>  DNA
<213>  Gallus gallus domesticus

<400>  94
atgatgacag acataaaaga tggaccacgc tcaggggaag atgtatcaga tgcaagatct       60

ttccctggtt ccaaaggaat gaacttacct gctagcaagt ctgtggactc tggaattctg      120

cctgatgaca gttacagaat ggattatcca gagataggag tatgtgttat aataaacaat      180

aagaacttcc accgagatac cggactgtca tctcgttcag gcacggatgc agatgctgca      240

agtgtcagag aagtttttat gaagctggga tataaagtca agcttaacaa tgatctgtca      300

agcagagata tttttaagct attgaaaaat gtttctgaag aagatcacag caagcgaagc      360

agttttgttt gtgtgttgct aagccatggc gatgaaggac tcttctatgg tacagatggc      420

cctcttgaac tgaaagtact aaccagcctt ttcagaggtg acaagtgcag aagtctagca      480

gggaaaccca aactcttttt cattcaggcc tgtagaggaa cagaattaga ttctggtatt      540

gaagcagaca gtggaccaga tgaaacagtg tgtcaaaaaa tacctgtaga agcagacttc      600

ctgtatgcat attctactgc tccaggctac tactcctgga ggaacgcagc tgaaggctcc      660

tggtttattc agtctctgtg taggatgctg aaggaacacg ccaggaaact tgaactcatg      720

cagattttaa ctcgtgtaaa tcgcagagtg gcagaatatg aatcctgctc cactcgacag      780

gatttcaatg caaagaaaca gattccatgc attgtgtcta tgcttaccaa agaattctac      840

tttccttgct aa                                                          852


<210>  95
<211>  283
<212>  PRT
<213>  Gallus gallus domesticus

<400>  95

Met Met Thr Asp Ile Lys Asp Gly Pro Arg Ser Gly Glu Asp Val Ser 
1               5                   10                  15      


Asp Ala Arg Ser Phe Pro Gly Ser Lys Gly Met Asn Leu Pro Ala Ser 
            20                  25                  30          


Lys Ser Val Asp Ser Gly Ile Leu Pro Asp Asp Ser Tyr Arg Met Asp 
        35                  40                  45              


Tyr Pro Glu Ile Gly Val Cys Val Ile Ile Asn Asn Lys Asn Phe His 
    50                  55                  60                  


Arg Asp Thr Gly Leu Ser Ser Arg Ser Gly Thr Asp Ala Asp Ala Ala 
65                  70                  75                  80  


Ser Val Arg Glu Val Phe Met Lys Leu Gly Tyr Lys Val Lys Leu Asn 
                85                  90                  95      


Asn Asp Leu Ser Ser Arg Asp Ile Phe Lys Leu Leu Lys Asn Val Ser 
            100                 105                 110         


Glu Glu Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser 
        115                 120                 125             


His Gly Asp Glu Gly Leu Phe Tyr Gly Thr Asp Gly Pro Leu Glu Leu 
    130                 135                 140                 


Lys Val Leu Thr Ser Leu Phe Arg Gly Asp Lys Cys Arg Ser Leu Ala 
145                 150                 155                 160 


Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu 
                165                 170                 175     


Asp Ser Gly Ile Glu Ala Asp Ser Gly Pro Asp Glu Thr Val Cys Gln 
            180                 185                 190         


Lys Ile Pro Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro 
        195                 200                 205             


Gly Tyr Tyr Ser Trp Arg Asn Ala Ala Glu Gly Ser Trp Phe Ile Gln 
    210                 215                 220                 


Ser Leu Cys Arg Met Leu Lys Glu His Ala Arg Lys Leu Glu Leu Met 
225                 230                 235                 240 


Gln Ile Leu Thr Arg Val Asn Arg Arg Val Ala Glu Tyr Glu Ser Cys 
                245                 250                 255     


Ser Thr Arg Gln Asp Phe Asn Ala Lys Lys Gln Ile Pro Cys Ile Val 
            260                 265                 270         


Ser Met Leu Thr Lys Glu Phe Tyr Phe Pro Cys 
        275                 280             


<210>  96
<211>  852
<212>  DNA
<213>  Gallus gallus domesticus

<400>  96
atgatgacag acataaaaga tggaccacgc tcaggggaag atgtatcagc tgcaagatct       60

ttccctggtt ccaaaggaat gaacttacct gctagcaagt ctgtggcctc tggaattctg      120

cctgatgaca gttacagaat ggattatcca gagataggag tatgtgttat aataaacaat      180

aagaacttcc accgagatac cggactgtca tctcgttcag gcacggatgc agatgctgca      240

agtgtcagag aagtttttat gaagctggga tataaagtca agcttaacaa tgatctgtca      300

agcagagata tttttaagct attgaaaaat gtttctgaag aagatcacag caagcgaagc      360

agttttgttt gtgtgttgct aagccatggc gatgaaggac tcttctatgg tacagatggc      420

cctcttgaac tgaaagtact aaccagcctt ttcagaggtg acaagtgcag aagtctagca      480

gggaaaccca aactcttttt cattcaggcc tgtagaggaa cagaattaga ttctggtatt      540

gaagcagcca gtggaccaga tgaaacagtg tgtcaaaaaa tacctgtaga agcagacttc      600

ctgtatgcat attctactgc tccaggctac tactcctgga ggaacgcagc tgaaggctcc      660

tggtttattc agtctctgtg taggatgctg aaggaacacg ccaggaaact tgaactcatg      720

cagattttaa ctcgtgtaaa tcgcagagtg gcagaatatg aatcctgctc cactcgacag      780

gatttcaatg caaagaaaca gattccatgc attgagtcta tgcttaccaa agaattctac      840

tttccttgct aa                                                          852


<210>  97
<211>  283
<212>  PRT
<213>  Gallus gallus domesticus

<400>  97

Met Met Thr Asp Ile Lys Asp Gly Pro Arg Ser Gly Glu Asp Val Ser 
1               5                   10                  15      


Ala Ala Arg Ser Phe Pro Gly Ser Lys Gly Met Asn Leu Pro Ala Ser 
            20                  25                  30          


Lys Ser Val Ala Ser Gly Ile Leu Pro Asp Asp Ser Tyr Arg Met Asp 
        35                  40                  45              


Tyr Pro Glu Ile Gly Val Cys Val Ile Ile Asn Asn Lys Asn Phe His 
    50                  55                  60                  


Arg Asp Thr Gly Leu Ser Ser Arg Ser Gly Thr Asp Ala Asp Ala Ala 
65                  70                  75                  80  


Ser Val Arg Glu Val Phe Met Lys Leu Gly Tyr Lys Val Lys Leu Asn 
                85                  90                  95      


Asn Asp Leu Ser Ser Arg Asp Ile Phe Lys Leu Leu Lys Asn Val Ser 
            100                 105                 110         


Glu Glu Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser 
        115                 120                 125             


His Gly Asp Glu Gly Leu Phe Tyr Gly Thr Asp Gly Pro Leu Glu Leu 
    130                 135                 140                 


Lys Val Leu Thr Ser Leu Phe Arg Gly Asp Lys Cys Arg Ser Leu Ala 
145                 150                 155                 160 


Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu 
                165                 170                 175     


Asp Ser Gly Ile Glu Ala Ala Ser Gly Pro Asp Glu Thr Val Cys Gln 
            180                 185                 190         


Lys Ile Pro Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro 
        195                 200                 205             


Gly Tyr Tyr Ser Trp Arg Asn Ala Ala Glu Gly Ser Trp Phe Ile Gln 
    210                 215                 220                 


Ser Leu Cys Arg Met Leu Lys Glu His Ala Arg Lys Leu Glu Leu Met 
225                 230                 235                 240 


Gln Ile Leu Thr Arg Val Asn Arg Arg Val Ala Glu Tyr Glu Ser Cys 
                245                 250                 255     


Ser Thr Arg Gln Asp Phe Asn Ala Lys Lys Gln Ile Pro Cys Ile Glu 
            260                 265                 270         


Ser Met Leu Thr Lys Glu Phe Tyr Phe Pro Cys 
        275                 280             


<210>  98
<211>  672
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Noggin Nucleotide

<400>  98
atggatcatt cccagtgcct tgtgactata tacgccgcgg cggtgctgct ggggctccgg       60

ctgcagcagg gctcctgcca gcactacctg cacatccgcc cggctcccag cgacaacctg      120

cccctggtgg atctaatcga gcacccggac cctatctttg accccaagga gaaggatctt      180

aacgagacct tgctaaggag cctcatggga ggacacttcg accctaactt tatggctatg      240

tccctgcccg aggaccggct cggggtagac gatctggccg agctggactt gctgctgcgg      300

cagagaccct cgggagcgat gcccggcgaa atcaaggggc tggagttcta cgacgggctg      360

cagccgggca agaagcacag gctgagcaag aagctgcgca ggaagctgca gatgtggctc      420

tggtcccaga ccttctgccc ggtcctatac acgtggaacg atctcggcag ccgcttttgg      480

ccccggtacg tcaaagtggg cagctgctac agtaaaaggt cttgctctgt cccagaaggc      540

atggtctgca aacctgccaa gtccgtgcat ttaacgatcc tgaggtggcg gtgccagcgg      600

cggggcgggc agcggtgcac gtggatcccc atccagtacc ccatcatcgc ggagtgcaag      660

tgctcctgct ag                                                          672


<210>  99
<211>  223
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Noggin Aminoacid

<400>  99

Met Asp His Ser Gln Cys Leu Val Thr Ile Tyr Ala Ala Ala Val Leu 
1               5                   10                  15      


Leu Gly Leu Arg Leu Gln Gln Gly Ser Cys Gln His Tyr Leu His Ile 
            20                  25                  30          


Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu His 
        35                  40                  45              


Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr Leu 
    50                  55                  60                  


Leu Arg Ser Leu Met Gly Gly His Phe Asp Pro Asn Phe Met Ala Met 
65                  70                  75                  80  


Ser Leu Pro Glu Asp Arg Leu Gly Val Asp Asp Leu Ala Glu Leu Asp 
                85                  90                  95      


Leu Leu Leu Arg Gln Arg Pro Ser Gly Ala Met Pro Gly Glu Ile Lys 
            100                 105                 110         


Gly Leu Glu Phe Tyr Asp Gly Leu Gln Pro Gly Lys Lys His Arg Leu 
        115                 120                 125             


Ser Lys Lys Leu Arg Arg Lys Leu Gln Met Trp Leu Trp Ser Gln Thr 
    130                 135                 140                 


Phe Cys Pro Val Leu Tyr Thr Trp Asn Asp Leu Gly Ser Arg Phe Trp 
145                 150                 155                 160 


Pro Arg Tyr Val Lys Val Gly Ser Cys Tyr Ser Lys Arg Ser Cys Ser 
                165                 170                 175     


Val Pro Glu Gly Met Val Cys Lys Pro Ala Lys Ser Val His Leu Thr 
            180                 185                 190         


Ile Leu Arg Trp Arg Cys Gln Arg Arg Gly Gly Gln Arg Cys Thr Trp 
        195                 200                 205             


Ile Pro Ile Gln Tyr Pro Ile Ile Ala Glu Cys Lys Cys Ser Cys 
    210                 215                 220             


<210>  100
<211>  1686
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAGG promotor

<400>  100
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggtta                                                                1686


<210>  101
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optogen 1 - NLS-Cry2-delta535-L348F-Cre-N (AA 19-104)

<400>  101
atgcctaaaa agaagcgtaa agtcatgaag atgaagatgg acaaaaagac tatagtttgg       60

tttagaagag acctaaggat tgaggataat cctgcattag cagcagctgc tcacgaagga      120

tctgtttttc ctgtcttcat ttggtgtcct gaagaagaag gacagtttta tcctggaaga      180

gcttcaagat ggtggatgaa acaatcactt gctcacttat ctcaatcctt gaaggctctt      240

ggatctgacc tcactttaat caaaacccac aacacgattt cagcgatctt ggattgtatc      300

cgcgttaccg gtgctacaaa agtcgtcttt aaccacctct atgatcctgt ttcgttagtt      360

cgggaccata ccgtaaagga gaagctggtg gaacgtggga tctctgtgca aagctacaat      420

ggagatctat tgtatgaacc gtgggagata tactgcgaaa agggcaaacc ttttacgagt      480

ttcaattctt actggaagaa atgcttagat atgtcgattg aatccgttat gcttcctcct      540

ccttggcggt tgatgccaat aactgcagcg gctgaagcga tttgggcgtg ttcgattgaa      600

gaactagggc tggagaatga ggccgagaaa ccgagcaatg cgttgttaac tagagcttgg      660

tctccaggat ggagcaatgc tgataagtta ctaaatgagt tcatcgagaa gcagttgata      720

gattatgcaa agaacagcaa gaaagttgtt gggaattcta cttcactact ttctccgtat      780

ctccatttcg gggaaataag cgtcagacac gttttccagt gtgcccggat gaaacaaatt      840

atatgggcaa gagataagaa cagtgaagga gaagaaagtg cagatctttt tcttagggga      900

atcggtttaa gagagtattc tcggtatata tgtttcaact tcccgtttac tcacgagcaa      960

tcgttgttga gtcatcttcg gtttttccct tgggatgctg atgttgataa gttcaaggcc     1020

tggagacaag gcaggaccgg ttatccgttg gtggatgccg gaatgagaga gttttgggct     1080

accggatgga tgcataacag aataagagtg attgtttcaa gctttgctgt gaagtttctt     1140

ctccttccat ggaaatgggg aatgaagtat ttctgggata cacttttgga tgctgatttg     1200

gaatgtgaca tccttggctg gcagtatatc tctgggagta tccccgatgg ccacgagctt     1260

gatcgcttgg acaatcccgc gttacaaggc gccaaatatg acccagaagg tgagtacata     1320

aggcaatggc ttcccgagct tgcgagattg ccaactgaat ggatccatca tccatgggac     1380

gctcctttaa ccgtactcaa agcttctggt gtggaactcg gaacaaacta tgcgaaaccc     1440

attgtagaca tcgacacagc tcgtgagcta ctagctaaag ctatttcaag aacccgtgaa     1500

gcacagatca tgatcggagc agcacctgat gagattgtag cagatagctt cgaggcctta     1560

ggggctaata ccattaaaga acctggtctt tgcccatctg tgtcttctaa tgaccaacaa     1620

gtaccttcgg ctgttggtgg cggtggctct ggaggtggtg ggtccggagg aggcggccgc     1680

acgagtgatg aggttcgcaa gaacctgatg gacatgttca gggatcgcca ggcgttttct     1740

gagcatacct ggaaaatgct tctgtccgtt tgccggtcgt gggcggcatg gtgcaagttg     1800

aataaccgga aatggtttcc cgcagaacct gaagatgttc gcgattatct tctatatctt     1860

caggcgcgcg gtctggcagt aaaaactatc cagcaacatt tgggccagct aaacatgctt     1920

catcgtcggt ccgggctgta a                                               1941


<210>  102
<211>  1275
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Optogen 2 - CIBN(aa1-170)-NLS-Cre-C(aa106-343)

<400>  102
atgaatggag ctataggagg tgaccttttg ctcaattttc ctgacatgtc ggtcctagag       60

cgccaaaggg ctcacctcaa gtacctcaat cccacctttg attctcctct cgccggcttc      120

tttgccgatt cttcaatgat taccggcggc gagatggaca gctatctttc gactgccggt      180

ttgaatcttc cgatgatgta cggtgagacg acggtggaag gtgattcaag actctcaatt      240

tcgccggaaa cgacgcttgg gactggaaat ttcaagaaac ggaagtttga tacagagact      300

aaggattgta atgagaagaa gaagaagatg acgatgaaca gagatgacct agtagaagaa      360

ggagaagaag agaagtcgaa aataacagag caaaacaatg ggagcacaaa aagcatcaag      420

aagatgaaac acaaagccaa gaaagaagag aacaatttct ctaatgattc atctaaagtg      480

acgaaggaat tggagaaaac ggattatatt catggtggcg gtggctctgg aggtggtggg      540

tccggaggag gcggccgccg accaagtgac agcaatgctg tttcactggt tatgcggcgg      600

atccgaaaag aaaacgttga tgccggtgaa cgtgcaaaac aggctctagc gttcgaacgc      660

actgatttcg accaggttcg ttcactcatg gaaaatagcg atcgctgcca ggatatacgt      720

aatctggcat ttctggggat tgcttataac accctgttac gtatagccga aattgccagg      780

atcagggtta aagatatctc acgtactgac ggtgggagaa tgttaatcca tattggcaga      840

acgaaaacgc tggttagcac cgcaggtgta gagaaggcac ttagcctggg ggtaactaaa      900

ctggtcgagc gatggatttc cgtctctggt gtagctgatg atccgaataa ctacctgttt      960

tgccgggtca gaaaaaatgg tgttgccgcg ccatctgcca ccagccagct atcaactcgc     1020

gccctggaag ggatttttga agcaactcat cgattgattt acggcgctaa ggatgactct     1080

ggtcagagat acctggcctg gtctggacac agtgcccgtg tcggagccgc gcgagatatg     1140

gcccgcgctg gagtttcaat accggagatc atgcaagctg gtggctggac caatgtaaat     1200

attgtcatga actatatccg taacctggat agtgaaacag gggcaatggt gcgcctgctg     1260

gaagatggcg attag                                                      1275


<210>  103
<211>  585
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IRES sequence

<400>  103
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccaca                      585


<210>  104
<211>  524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polyadenylation site sequence (Rabbit beta-globin)

<400>  104
actcctcagg tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct       60

cacaaatacc actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc      120

cttgagcatc tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg      180

aattttttgt gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag      240

aatgagtatt tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa      300

ggttggctat aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc      360

catagaaaag ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt      420

tctttaacat ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc      480

tgactactcc cagtcatagc tgtccctctt ctcttatgga gatc                       524


<210>  105
<211>  1496
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5 homology arm

<400>  105
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttca         1496


<210>  106
<211>  1564
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3 homology arm

<400>  106
gccgtttcca cattcttttc tcatccttct tctcctgttt tctctgcatc aaggtcagca       60

cgatagcact gtctctctat gcttagggag aggcctgtcc tgtacatccc gtgcccccac      120

aagatgccta ctacaacaac atcttctgca tgtcctgcat agcagtgttg ggagaatgtg      180

cactacttcc actcttctga tttctatttt atgtgtttgc tttataccag tgttgccatt      240

tgggaattaa tacatggttg atcaaatcaa ttgcatcaca gctgtatcct gtatcagagg      300

aacattatca aagcttttgt tgctgtattt ggtatctgac ctgcagataa acatgtttta      360

ggaaggtttt gcaaaagtag ctgtgaaatg agctggtgtt gtgatttaac ctgacaggca      420

gctaaacagt ataccacaga gctattcacc tactttccct cagtgggaaa agggaagaga      480

actgaggggg gggggaataa ataagtaaat aacaaaataa aactcatgga ttaagaaaaa      540

gactttgtac tggaatggat gagaagaata atagtaatga taataatatg tcactctgaa      600

agtaatgcct cttatttctg tggagactac aaacatacaa agagcacaac attccataga      660

gcaaattctc agttacagaa tgctattttt tttttcaaca cagtcaaaat cattaatttt      720

tttttgcctg caatggacaa gagctttgaa gctgttctcg taaaaatctg tactagcaga      780

agtgacctgc aatcactact gctgaaatgc acaacccacc acatcattgt gctcacattc      840

actgtttggt ttctgtaaat gtacaggaat tgtctgaaat tagatatgat tttttttttc      900

tccatgaagg aattcaatta cacacctttg cctcatgcac ttctttgtca tttttgtcag      960

actgcttctc tcctgcaatt tgtctcatgg caacaaaata taatggagtt ctgctgggaa     1020

cttccctact gccataccac tatcatctgc ctctgacatt ttggacaaat gtaataaaat     1080

aggaggtatt actttcagag cagaccttgt atgtatttac aaaacaagtg gtacacaaaa     1140

aaaattgttc atcccaccaa ccaatgccca tcctgtccct gaatagtagc tgtcccccac     1200

agccttgacc agtttaggtc aacagttctg cttctgtccc ctcccagctc cttgtaaccc     1260

ctcagccccc cttgctggca ggacagtatg agaagctgaa aaactagaat gtcctagttc     1320

tttgcagtgc tgctaatcaa caaccaaaac agtggtgtgt taccaatatt gttgatatca     1380

cagcatcata ccattatgaa ggaagtaacc cagccaaaat caggtcagct tgctaacaag     1440

agaactgtgc ataagtttaa gatgtgtgtg ttcctcagta ccttaaaaaa taagtagtaa     1500

cgttcaaatg agtagaagag tagaactgag cttaaaacat ctgtcagaca acagtgaacc     1560

aacc                                                                  1564


<210>  107
<211>  627
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cre-N(aa18-59)_N-Mag_NLS

<400>  107
atggccacct ctgatgaagt caggaagaac ctgatggaca tgttcaggga caggcaggcc       60

ttctctgaac acacctggaa gatgctcctg tctgtgtgca gatcctgggc tgcctggtgc      120

aagctgaacg gtacccatac tctttatgcc cccggtggat atgacattat gggatatctg      180

gaccagatcg gcaaccggcc aaacccgcag gtggaactgg gccccgtgga tacatcctgc      240

gccttgattc tttgtgacct gaaacagaaa gacaccccga tagtttacgc gagtgaagcc      300

ttcctctaca tgacaggtta cagcaacgca gaggtgctgg gccggaattg ccggtttctg      360

caaagccctg acggcatggt gaagcccaag agcacccgga agtacgtgga tagtaacaca      420

atcaatacta tgcgcaaggc aatcgacagg aatgccgagg tgcaggttga agtagtcaat      480

tttaaaaaga atggacagcg atttgttaat ttcctgacta tgatacctgt tagggacgaa      540

acaggcgagt atcgatactc tatgggattc cagtgcgaaa cagaaggcgg aagcggtggc      600

gtgcccaaga agaagaggaa agtctag                                          627


<210>  108
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NLS_P-Mag_Cre-C(aa60-237)

<400>  108
atggtgccca agaagaagag gaaagtcggc ggacatactc tttatgcccc cggtggatat       60

gacattatgg gatatctgag gcagatcagg aaccggccaa acccgcaggt ggaactgggc      120

cccgtggata catcctgcgc cttgattctt tgtgacctga aacagaaaga caccccgata      180

gtttacgcga gtgaagcctt cctctacatg acaggttaca gcaacgcaga ggtgctgggc      240

cggaattgcc ggtttctgca aagccctgac ggcatggtga agcccaagag cacccggaag      300

tacgtggata gtaacacaat caatactatg cgcaaggcaa tcgacaggaa tgccgaggtg      360

caggttgaag tagtcaattt taaaaagaat ggacagcgat ttgttaattt cctgactatg      420

atacctgtta gggacgaaac aggcgagtat cgatactcta tgggattcca gtgcgaaaca      480

gaaggtacca acaggaaatg gttccctgct gaacctgagg atgtgaggga ctacctcctg      540

tacctgcaag ccagaggcct ggctgtgaag accatccaac agcacctggg ccagctcaac      600

atgctgcaca ggagatctgg cctgcctcgc ccttctgact ccaatgctgt gtccctggtg      660

atgaggagaa tcagaaagga gaatgtggat gctggggaga gagccaagca ggccctggcc      720

tttgaacgca ctgactttga ccaagtcaga tccctgatgg agaactctga cagatgccag      780

gacatcagga acctggcctt cctgggcatt gcctacaaca ccctgctgcg cattgccgaa      840

attgccagaa tcagagtgaa ggacatctcc cgcaccgatg gtgggagaat gctgatccac      900

attggcagga ccaagaccct ggtgtccaca gctggtgtgg agaaggccct gtccctgggg      960

gttaccaagc tggtggagag atggatctct gtgtctggtg tggctgatga ccccaacaac     1020

tacctgttct gccgggtcag aaagaatggt gtggctgccc cttctgccac ctcccaactg     1080

tccacccggg ccctggaagg gatctttgag gccacccacc gcctgatcta tggtgccaag     1140

gatgactctg ggcagagata cctggcctgg tctggccact ctgccagagt gggtgctgcc     1200

agggacatgg ccagggctgg tgtgtccatc cctgaaatca tgcaggctgg tggctggacc     1260

aatgtgaaca ttgtgatgaa ctacatcaga aacctggact ctgagactgg ggccatggtg     1320

aggctgctcg aagatgggga ctag                                            1344


<210>  109
<211>  509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGK promotor

<400>  109
accgggtagg ggaggcgctt ttcccaaggc agtctggagc atgcgcttta gcagccccgc       60

tgggcacttg gcgctacaca agtggcctct ggcctcgcac acattccaca tccaccggta      120

ggcgccaacc ggctccgttc tttggtggcc ccttcgcgcc accttctact cctcccctag      180

tcaggaagtt cccccccgcc ccgcagctcg cgtcgtgcag gacgtgacaa atggaagtag      240

cacgtctcac tagtctcgtg cagatggaca gcaccgctga gcaatggaag cgggtaggcc      300

tttggggcag cggccaatag cagctttgct ccttcgcttt ctgggctcag aggctgggaa      360

ggggtgggtc cgggggcggg ctcaggggcg ggctcagggg cggggcgggc gcccgaaggt      420

cctccggagg cccggcattc tgcacgcttc aaaagcgcac gtctgccgcg ctgttctcct      480

cttcctcatc tccgggcctt tcgacctgc                                        509


<210>  110
<211>  508
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCMV promotor

<400>  110
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  111
<211>  448
<212>  DNA
<213>  Artificial sequence

<220>
<223>  phSyn promotor

<400>  111
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  112
<211>  1189
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pEFl-a promotor

<400>  112
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacgcccctg gctgcagtac gtgattcttg atcccgagct tcgggttgga      360

agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt      420

gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt      480

ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt      540

tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt      600

tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg      660

ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct      720

ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg      780

tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca      840

aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg      900

gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg      960

cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt     1020

tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac     1080

ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag     1140

cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgag                 1189


<210>  113
<211>  1056
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cre recombinase

<400>  113
atggcaccca agaagaagag gaaggtgtcc aatttactga ccgtacacca aaatttgcct       60

gcattaccgg tcgatgcaac gagtgatgag gttcgcaaga acctgatgga catgttcagg      120

gatcgccagg cgttttctga gcatacctgg aaaatgcttc tgtccgtttg ccggtcgtgg      180

gcggcatggt gcaagttgaa taaccggaaa tggtttcccg cagaacctga agatgttcgc      240

gattatcttc tatatcttca ggcgcgcggt ctggcagtaa aaactatcca gcaacatttg      300

ggccagctaa acatgcttca tcgtcggtcc gggctgccac gaccaagtga cagcaatgct      360

gtttcactgg ttatgcggcg gatccgaaaa gaaaacgttg atgccggtga acgtgcaaaa      420

caggctctag cgttcgaacg cactgatttc gaccaggttc gttcactcat ggaaaatagc      480

gatcgctgcc aggatatacg taatctggca tttctgggga ttgcttataa caccctgtta      540

cgtatagccg aaattgccag gatcagggtt aaagatatct cacgtactga cggtgggaga      600

atgttaatcc atattggcag aacgaaaacg ctggttagca ccgcaggtgt agagaaggca      660

cttagcctgg gggtaactaa actggtcgag cgatggattt ccgtctctgg tgtagctgat      720

gatccgaata actacctgtt ttgccgggtc agaaaaaatg gtgttgccgc gccatctgcc      780

accagccagc tatcaactcg cgccctggaa gggatttttg aagcaactca tcgattgatt      840

tacggcgcta aggatgactc tggtcagaga tacctggcct ggtctggaca cagtgcccgt      900

gtcggagccg cgcgagatat ggcccgcgct ggagtttcaa taccggagat catgcaagct      960

ggtggctgga ccaatgtaaa tattgtcatg aactatatcc gtaacctgga tagtgaaaca     1020

ggggcaatgg tgcgcctgct ggaagatggc gattag                               1056


<210>  114
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Positive Mag recombinase

<400>  114
catactcttt atgcccccgg tggatatgac attatgggat atctgaggca gatcaggaac       60

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt      120

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca      180

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc      240

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc      300

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga      360

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga      420

tactctatgg gattccagtg cgaaacagaa                                       450


<210>  115
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  green fluorescence protein (GFP)

<400>  115
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  116
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Lox site

<400>  116
ataacttcgt ataatgtatg ctatacgaag ttat                                   34


<210>  117
<211>  258
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CreN (AA 19-104)

<400>  117
acgagtgatg aggttcgcaa gaacctgatg gacatgttca gggatcgcca ggcgttttct       60

gagcatacct ggaaaatgct tctgtccgtt tgccggtcgt gggcggcatg gtgcaagttg      120

aataaccgga aatggtttcc cgcagaacct gaagatgttc gcgattatct tctatatctt      180

caggcgcgcg gtctggcagt aaaaactatc cagcaacatt tgggccagct aaacatgctt      240

catcgtcggt ccgggctg                                                    258


<210>  118
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CreC (AA 106-343)

<400>  118
cgaccaagtg acagcaatgc tgtttcactg gttatgcggc ggatccgaaa agaaaacgtt       60

gatgccggtg aacgtgcaaa acaggctcta gcgttcgaac gcactgattt cgaccaggtt      120

cgttcactca tggaaaatag cgatcgctgc caggatatac gtaatctggc atttctgggg      180

attgcttata acaccctgtt acgtatagcc gaaattgcca ggatcagggt taaagatatc      240

tcacgtactg acggtgggag aatgttaatc catattggca gaacgaaaac gctggttagc      300

accgcaggtg tagagaaggc acttagcctg ggggtaacta aactggtcga gcgatggatt      360

tccgtctctg gtgtagctga tgatccgaat aactacctgt tttgccgggt cagaaaaaat      420

ggtgttgccg cgccatctgc caccagccag ctatcaactc gcgccctgga agggattttt      480

gaagcaactc atcgattgat ttacggcgct aaggatgact ctggtcagag atacctggcc      540

tggtctggac acagtgcccg tgtcggagcc gcgcgagata tggcccgcgc tggagtttca      600

ataccggaga tcatgcaagc tggtggctgg accaatgtaa atattgtcat gaactatatc      660

cgtaacctgg atagtgaaac aggggcaatg gtgcgcctgc tggaagatgg cgattag         717


<210>  119
<211>  711
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCherry/RFP

<400>  119
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta a               711


<210>  120
<211>  9811
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV1

<400>  120
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatggc cacctctgat     4440

gaagtcagga agaacctgat ggacatgttc agggacaggc aggccttctc tgaacacacc     4500

tggaagatgc tcctgtctgt gtgcagatcc tgggctgcct ggtgcaagct gaacggtacc     4560

catactcttt atgcccccgg tggatatgac attatgggat atctggacca gatcggcaac     4620

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt     4680

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca     4740

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc     4800

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc     4860

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga     4920

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga     4980

tactctatgg gattccagtg cgaaacagaa ggcggaagcg gtggcgtgcc caagaagaag     5040

aggaaagtct tcgaaggcag cggcgccacc aacttcagcc tgctgaagca ggccggcgac     5100

gtggaggaga accccggccc cttcgaagtg cccaagaaga agaggaaagt cggcggacat     5160

actctttatg cccccggtgg atatgacatt atgggatatc tgaggcagat caggaaccgg     5220

ccaaacccgc aggtggaact gggccccgtg gatacatcct gcgccttgat tctttgtgac     5280

ctgaaacaga aagacacccc gatagtttac gcgagtgaag ccttcctcta catgacaggt     5340

tacagcaacg cagaggtgct gggccggaat tgccggtttc tgcaaagccc tgacggcatg     5400

gtgaagccca agagcacccg gaagtacgtg gatagtaaca caatcaatac tatgcgcaag     5460

gcaatcgaca ggaatgccga ggtgcaggtt gaagtagtca attttaaaaa gaatggacag     5520

cgatttgtta atttcctgac tatgatacct gttagggacg aaacaggcga gtatcgatac     5580

tctatgggat tccagtgcga aacagaaggt accaacagga aatggttccc tgctgaacct     5640

gaggatgtga gggactacct cctgtacctg caagccagag gcctggctgt gaagaccatc     5700

caacagcacc tgggccagct caacatgctg cacaggagat ctggcctgcc tcgcccttct     5760

gactccaatg ctgtgtccct ggtgatgagg agaatcagaa aggagaatgt ggatgctggg     5820

gagagagcca agcaggccct ggcctttgaa cgcactgact ttgaccaagt cagatccctg     5880

atggagaact ctgacagatg ccaggacatc aggaacctgg ccttcctggg cattgcctac     5940

aacaccctgc tgcgcattgc cgaaattgcc agaatcagag tgaaggacat ctcccgcacc     6000

gatggtggga gaatgctgat ccacattggc aggaccaaga ccctggtgtc cacagctggt     6060

gtggagaagg ccctgtccct gggggttacc aagctggtgg agagatggat ctctgtgtct     6120

ggtgtggctg atgaccccaa caactacctg ttctgccggg tcagaaagaa tggtgtggct     6180

gccccttctg ccacctccca actgtccacc cgggccctgg aagggatctt tgaggccacc     6240

caccgcctga tctatggtgc caaggatgac tctgggcaga gatacctggc ctggtctggc     6300

cactctgcca gagtgggtgc tgccagggac atggccaggg ctggtgtgtc catccctgaa     6360

atcatgcagg ctggtggctg gaccaatgtg aacattgtga tgaactacat cagaaacctg     6420

gactctgaga ctggggccat ggtgaggctg ctcgaagatg gggactaatt aattaactcc     6480

tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg gccaatgccc tggctcacaa     6540

ataccactga gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     6600

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     6660

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     6720

gtatttggtt tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg     6780

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     6840

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     6900

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     6960

actcccagtc atagctgtcc ctcttctctt atggagatca taacttcgta taatgtatgc     7020

tatacgaagt tatacgcgtg ccaccatgga tcattcccag tgccttgtga ctatatacgc     7080

cgcggcggtg ctgctggggc tccggctgca gcagggctcc tgccagcact acctgcacat     7140

ccgcccggct cccagcgaca acctgcccct ggtggatcta atcgagcacc cggaccctat     7200

ctttgacccc aaggagaagg atcttaacga gaccttgcta aggagcctca tgggaggaca     7260

cttcgaccct aactttatgg ctatgtccct gcccgaggac cggctcgggg tagacgatct     7320

ggccgagctg gacttgctgc tgcggcagag accctcggga gcgatgcccg gcgaaatcaa     7380

ggggctggag ttctacgacg ggctgcagcc gggcaagaag cacaggctga gcaagaagct     7440

gcgcaggaag ctgcagatgt ggctctggtc ccagaccttc tgcccggtcc tatacacgtg     7500

gaacgatctc ggcagccgct tttggccccg gtacgtcaaa gtgggcagct gctacagtaa     7560

aaggtcttgc tctgtcccag aaggcatggt ctgcaaacct gccaagtccg tgcatttaac     7620

gatcctgagg tggcggtgcc agcggcgggg cgggcagcgg tgcacgtgga tccccatcca     7680

gtaccccatc atcgcggagt gcaagtgctc ctgctagacg cgtactcctc aggtgcaggc     7740

tgcctatcag aaggtggtgg ctggtgtggc caatgccctg gctcacaaat accactgaga     7800

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     7860

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     7920

actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta     7980

gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg     8040

tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac     8100

ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa     8160

attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat     8220

agctgtccct cttctcttat ggagatcgcc gtttccacat tcttttctca tccttcttct     8280

cctgttttct ctgcatcaag gtcagcacga tagcactgtc tctctatgct tagggagagg     8340

cctgtcctgt acatcccgtg cccccacaag atgcctacta caacaacatc ttctgcatgt     8400

cctgcatagc agtgttggga gaatgtgcac tacttccact cttctgattt ctattttatg     8460

tgtttgcttt ataccagtgt tgccatttgg gaattaatac atggttgatc aaatcaattg     8520

catcacagct gtatcctgta tcagaggaac attatcaaag cttttgttgc tgtatttggt     8580

atctgacctg cagataaaca tgttttagga aggttttgca aaagtagctg tgaaatgagc     8640

tggtgttgtg atttaacctg acaggcagct aaacagtata ccacagagct attcacctac     8700

tttccctcag tgggaaaagg gaagagaact gagggggggg ggaataaata agtaaataac     8760

aaaataaaac tcatggatta agaaaaagac tttgtactgg aatggatgag aagaataata     8820

gtaatgataa taatatgtca ctctgaaagt aatgcctctt atttctgtgg agactacaaa     8880

catacaaaga gcacaacatt ccatagagca aattctcagt tacagaatgc tatttttttt     8940

ttcaacacag tcaaaatcat taattttttt ttgcctgcaa tggacaagag ctttgaagct     9000

gttctcgtaa aaatctgtac tagcagaagt gacctgcaat cactactgct gaaatgcaca     9060

acccaccaca tcattgtgct cacattcact gtttggtttc tgtaaatgta caggaattgt     9120

ctgaaattag atatgatttt ttttttctcc atgaaggaat tcaattacac acctttgcct     9180

catgcacttc tttgtcattt ttgtcagact gcttctctcc tgcaatttgt ctcatggcaa     9240

caaaatataa tggagttctg ctgggaactt ccctactgcc ataccactat catctgcctc     9300

tgacattttg gacaaatgta ataaaatagg aggtattact ttcagagcag accttgtatg     9360

tatttacaaa acaagtggta cacaaaaaaa attgttcatc ccaccaacca atgcccatcc     9420

tgtccctgaa tagtagctgt cccccacagc cttgaccagt ttaggtcaac agttctgctt     9480

ctgtcccctc ccagctcctt gtaacccctc agcccccctt gctggcagga cagtatgaga     9540

agctgaaaaa ctagaatgtc ctagttcttt gcagtgctgc taatcaacaa ccaaaacagt     9600

ggtgtgttac caatattgtt gatatcacag catcatacca ttatgaagga agtaacccag     9660

ccaaaatcag gtcagcttgc taacaagaga actgtgcata agtttaagat gtgtgtgttc     9720

ctcagtacct taaaaaataa gtagtaacgt tcaaatgagt agaagagtag aactgagctt     9780

aaaacatctg tcagacaaca gtgaaccaac c                                    9811


<210>  121
<211>  9796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV2

<400>  121
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatggc cacctctgat     4440

gaagtcagga agaacctgat ggacatgttc agggacaggc aggccttctc tgaacacacc     4500

tggaagatgc tcctgtctgt gtgcagatcc tgggctgcct ggtgcaagct gaacggtacc     4560

catactcttt atgcccccgg tggatatgac attatgggat atctggacca gatcggcaac     4620

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt     4680

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca     4740

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc     4800

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc     4860

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga     4920

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga     4980

tactctatgg gattccagtg cgaaacagaa ggcggaagcg gtggcgtgcc caagaagaag     5040

aggaaagtct tcgaaggcag cggcgccacc aacttcagcc tgctgaagca ggccggcgac     5100

gtggaggaga accccggccc cttcgaagtg cccaagaaga agaggaaagt cggcggacat     5160

actctttatg cccccggtgg atatgacatt atgggatatc tgaggcagat caggaaccgg     5220

ccaaacccgc aggtggaact gggccccgtg gatacatcct gcgccttgat tctttgtgac     5280

ctgaaacaga aagacacccc gatagtttac gcgagtgaag ccttcctcta catgacaggt     5340

tacagcaacg cagaggtgct gggccggaat tgccggtttc tgcaaagccc tgacggcatg     5400

gtgaagccca agagcacccg gaagtacgtg gatagtaaca caatcaatac tatgcgcaag     5460

gcaatcgaca ggaatgccga ggtgcaggtt gaagtagtca attttaaaaa gaatggacag     5520

cgatttgtta atttcctgac tatgatacct gttagggacg aaacaggcga gtatcgatac     5580

tctatgggat tccagtgcga aacagaaggt accaacagga aatggttccc tgctgaacct     5640

gaggatgtga gggactacct cctgtacctg caagccagag gcctggctgt gaagaccatc     5700

caacagcacc tgggccagct caacatgctg cacaggagat ctggcctgcc tcgcccttct     5760

gactccaatg ctgtgtccct ggtgatgagg agaatcagaa aggagaatgt ggatgctggg     5820

gagagagcca agcaggccct ggcctttgaa cgcactgact ttgaccaagt cagatccctg     5880

atggagaact ctgacagatg ccaggacatc aggaacctgg ccttcctggg cattgcctac     5940

aacaccctgc tgcgcattgc cgaaattgcc agaatcagag tgaaggacat ctcccgcacc     6000

gatggtggga gaatgctgat ccacattggc aggaccaaga ccctggtgtc cacagctggt     6060

gtggagaagg ccctgtccct gggggttacc aagctggtgg agagatggat ctctgtgtct     6120

ggtgtggctg atgaccccaa caactacctg ttctgccggg tcagaaagaa tggtgtggct     6180

gccccttctg ccacctccca actgtccacc cgggccctgg aagggatctt tgaggccacc     6240

caccgcctga tctatggtgc caaggatgac tctgggcaga gatacctggc ctggtctggc     6300

cactctgcca gagtgggtgc tgccagggac atggccaggg ctggtgtgtc catccctgaa     6360

atcatgcagg ctggtggctg gaccaatgtg aacattgtga tgaactacat cagaaacctg     6420

gactctgaga ctggggccat ggtgaggctg ctcgaagatg gggactaatt aattaactcc     6480

tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg gccaatgccc tggctcacaa     6540

ataccactga gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     6600

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     6660

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     6720

gtatttggtt tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg     6780

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     6840

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     6900

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     6960

actcccagtc atagctgtcc ctcttctctt atggagatca taacttcgta taatgtatgc     7020

tatacgaagt tatacgcgtg ccaccatgga tcctgatgat gttgttgatt cttctaaatc     7080

ttttgtgatg gaaaactttt cttcgtacca cgggactaaa cctggttatg tagattccat     7140

tcaaaaaggt atacaaaagc caaaatctgg tacacaagga aattatgacg atgattggaa     7200

agggttttat agtaccgaca ataaatacga cgctgcggga tactctgtag ataatgaaaa     7260

cccgctctct ggaaaagctg gaggcgtggt caaagtgacg tatccaggac tgacgaaggt     7320

tctcgcacta aaagtggata atgccgaaac tattaagaaa gagttaggtt taagtctcac     7380

tgaaccgttg atggagcaag tcggaacgga agagtttatc aaaaggttcg gtgatggtgc     7440

ttcgcgtgta gtgctcagcc ttcccttcgc tgaggggagt tctagcgttg aatatattaa     7500

taactgggaa caggcgaaag cgttaagcgt agaacttgag attaattttg aaacccgtgg     7560

aaaacgtggc caagatgcga tgtatgagta tatggctcaa gcctgtgcag gaaatcgtgt     7620

caggcgatct ctttgtgaag gaaccttact tctgtggtgt gacataattg gacaaactac     7680

ctacagagat ttaaagctct aaacgcgtac tcctcaggtg caggctgcct atcagaaggt     7740

ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt ttccctctgc     7800

caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa     7860

atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaaggacata     7920

tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt tggcaacata     7980

tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc agtatatgaa     8040

acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag gttagatttt     8100

ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt ccttacatgt     8160

tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg tccctcttct     8220

cttatggaga tcgccgtttc cacattcttt tctcatcctt cttctcctgt tttctctgca     8280

tcaaggtcag cacgatagca ctgtctctct atgcttaggg agaggcctgt cctgtacatc     8340

ccgtgccccc acaagatgcc tactacaaca acatcttctg catgtcctgc atagcagtgt     8400

tgggagaatg tgcactactt ccactcttct gatttctatt ttatgtgttt gctttatacc     8460

agtgttgcca tttgggaatt aatacatggt tgatcaaatc aattgcatca cagctgtatc     8520

ctgtatcaga ggaacattat caaagctttt gttgctgtat ttggtatctg acctgcagat     8580

aaacatgttt taggaaggtt ttgcaaaagt agctgtgaaa tgagctggtg ttgtgattta     8640

acctgacagg cagctaaaca gtataccaca gagctattca cctactttcc ctcagtggga     8700

aaagggaaga gaactgaggg gggggggaat aaataagtaa ataacaaaat aaaactcatg     8760

gattaagaaa aagactttgt actggaatgg atgagaagaa taatagtaat gataataata     8820

tgtcactctg aaagtaatgc ctcttatttc tgtggagact acaaacatac aaagagcaca     8880

acattccata gagcaaattc tcagttacag aatgctattt tttttttcaa cacagtcaaa     8940

atcattaatt tttttttgcc tgcaatggac aagagctttg aagctgttct cgtaaaaatc     9000

tgtactagca gaagtgacct gcaatcacta ctgctgaaat gcacaaccca ccacatcatt     9060

gtgctcacat tcactgtttg gtttctgtaa atgtacagga attgtctgaa attagatatg     9120

attttttttt tctccatgaa ggaattcaat tacacacctt tgcctcatgc acttctttgt     9180

catttttgtc agactgcttc tctcctgcaa tttgtctcat ggcaacaaaa tataatggag     9240

ttctgctggg aacttcccta ctgccatacc actatcatct gcctctgaca ttttggacaa     9300

atgtaataaa ataggaggta ttactttcag agcagacctt gtatgtattt acaaaacaag     9360

tggtacacaa aaaaaattgt tcatcccacc aaccaatgcc catcctgtcc ctgaatagta     9420

gctgtccccc acagccttga ccagtttagg tcaacagttc tgcttctgtc ccctcccagc     9480

tccttgtaac ccctcagccc cccttgctgg caggacagta tgagaagctg aaaaactaga     9540

atgtcctagt tctttgcagt gctgctaatc aacaaccaaa acagtggtgt gttaccaata     9600

ttgttgatat cacagcatca taccattatg aaggaagtaa cccagccaaa atcaggtcag     9660

cttgctaaca agagaactgt gcataagttt aagatgtgtg tgttcctcag taccttaaaa     9720

aataagtagt aacgttcaaa tgagtagaag agtagaactg agcttaaaac atctgtcaga     9780

caacagtgaa ccaacc                                                     9796


<210>  122
<211>  9991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV3

<400>  122
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatggc cacctctgat     4440

gaagtcagga agaacctgat ggacatgttc agggacaggc aggccttctc tgaacacacc     4500

tggaagatgc tcctgtctgt gtgcagatcc tgggctgcct ggtgcaagct gaacggtacc     4560

catactcttt atgcccccgg tggatatgac attatgggat atctggacca gatcggcaac     4620

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt     4680

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca     4740

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc     4800

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc     4860

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga     4920

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga     4980

tactctatgg gattccagtg cgaaacagaa ggcggaagcg gtggcgtgcc caagaagaag     5040

aggaaagtct tcgaaggcag cggcgccacc aacttcagcc tgctgaagca ggccggcgac     5100

gtggaggaga accccggccc cttcgaagtg cccaagaaga agaggaaagt cggcggacat     5160

actctttatg cccccggtgg atatgacatt atgggatatc tgaggcagat caggaaccgg     5220

ccaaacccgc aggtggaact gggccccgtg gatacatcct gcgccttgat tctttgtgac     5280

ctgaaacaga aagacacccc gatagtttac gcgagtgaag ccttcctcta catgacaggt     5340

tacagcaacg cagaggtgct gggccggaat tgccggtttc tgcaaagccc tgacggcatg     5400

gtgaagccca agagcacccg gaagtacgtg gatagtaaca caatcaatac tatgcgcaag     5460

gcaatcgaca ggaatgccga ggtgcaggtt gaagtagtca attttaaaaa gaatggacag     5520

cgatttgtta atttcctgac tatgatacct gttagggacg aaacaggcga gtatcgatac     5580

tctatgggat tccagtgcga aacagaaggt accaacagga aatggttccc tgctgaacct     5640

gaggatgtga gggactacct cctgtacctg caagccagag gcctggctgt gaagaccatc     5700

caacagcacc tgggccagct caacatgctg cacaggagat ctggcctgcc tcgcccttct     5760

gactccaatg ctgtgtccct ggtgatgagg agaatcagaa aggagaatgt ggatgctggg     5820

gagagagcca agcaggccct ggcctttgaa cgcactgact ttgaccaagt cagatccctg     5880

atggagaact ctgacagatg ccaggacatc aggaacctgg ccttcctggg cattgcctac     5940

aacaccctgc tgcgcattgc cgaaattgcc agaatcagag tgaaggacat ctcccgcacc     6000

gatggtggga gaatgctgat ccacattggc aggaccaaga ccctggtgtc cacagctggt     6060

gtggagaagg ccctgtccct gggggttacc aagctggtgg agagatggat ctctgtgtct     6120

ggtgtggctg atgaccccaa caactacctg ttctgccggg tcagaaagaa tggtgtggct     6180

gccccttctg ccacctccca actgtccacc cgggccctgg aagggatctt tgaggccacc     6240

caccgcctga tctatggtgc caaggatgac tctgggcaga gatacctggc ctggtctggc     6300

cactctgcca gagtgggtgc tgccagggac atggccaggg ctggtgtgtc catccctgaa     6360

atcatgcagg ctggtggctg gaccaatgtg aacattgtga tgaactacat cagaaacctg     6420

gactctgaga ctggggccat ggtgaggctg ctcgaagatg gggactaatt aattaactcc     6480

tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg gccaatgccc tggctcacaa     6540

ataccactga gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     6600

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     6660

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     6720

gtatttggtt tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg     6780

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     6840

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     6900

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     6960

actcccagtc atagctgtcc ctcttctctt atggagatca taacttcgta taatgtatgc     7020

tatacgaagt tatacgcgtg ccaccatgat gacagacata aaagatggac cacgctcagg     7080

ggaagatgta tcagctgcaa gatctttccc tggttccaaa ggaatgaact tacctgctag     7140

caagtctgtg gcctctggaa ttctgcctga tgacagttac agaatggatt atccagagat     7200

aggagtatgt gttataataa acaataagaa cttccaccga gataccggac tgtcatctcg     7260

ttcaggcacg gatgcagatg ctgcaagtgt cagagaagtt tttatgaagc tgggatataa     7320

agtcaagctt aacaatgatc tgtcaagcag agatattttt aagctattga aaaatgtttc     7380

tgaagaagat cacagcaagc gaagcagttt tgtttgtgtg ttgctaagcc atggcgatga     7440

aggactcttc tatggtacag atggccctct tgaactgaaa gtactaacca gccttttcag     7500

aggtgacaag tgcagaagtc tagcagggaa acccaaactc tttttcattc aggcctgtag     7560

aggaacagaa ttagattctg gtattgaagc agccagtgga ccagatgaaa cagtgtgtca     7620

aaaaatacct gtagaagcag acttcctgta tgcatattct actgctccag gctactactc     7680

ctggaggaac gcagctgaag gctcctggtt tattcagtct ctgtgtagga tgctgaagga     7740

acacgccagg aaacttgaac tcatgcagat tttaactcgt gtaaatcgca gagtggcaga     7800

atatgaatcc tgctccactc gacaggattt caatgcaaag aaacagattc catgcattga     7860

gtctatgctt accaaagaat tctactttcc ttgctaaacg cgtactcctc aggtgcaggc     7920

tgcctatcag aaggtggtgg ctggtgtggc caatgccctg gctcacaaat accactgaga     7980

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     8040

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     8100

actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta     8160

gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg     8220

tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac     8280

ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa     8340

attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat     8400

agctgtccct cttctcttat ggagatcgcc gtttccacat tcttttctca tccttcttct     8460

cctgttttct ctgcatcaag gtcagcacga tagcactgtc tctctatgct tagggagagg     8520

cctgtcctgt acatcccgtg cccccacaag atgcctacta caacaacatc ttctgcatgt     8580

cctgcatagc agtgttggga gaatgtgcac tacttccact cttctgattt ctattttatg     8640

tgtttgcttt ataccagtgt tgccatttgg gaattaatac atggttgatc aaatcaattg     8700

catcacagct gtatcctgta tcagaggaac attatcaaag cttttgttgc tgtatttggt     8760

atctgacctg cagataaaca tgttttagga aggttttgca aaagtagctg tgaaatgagc     8820

tggtgttgtg atttaacctg acaggcagct aaacagtata ccacagagct attcacctac     8880

tttccctcag tgggaaaagg gaagagaact gagggggggg ggaataaata agtaaataac     8940

aaaataaaac tcatggatta agaaaaagac tttgtactgg aatggatgag aagaataata     9000

gtaatgataa taatatgtca ctctgaaagt aatgcctctt atttctgtgg agactacaaa     9060

catacaaaga gcacaacatt ccatagagca aattctcagt tacagaatgc tatttttttt     9120

ttcaacacag tcaaaatcat taattttttt ttgcctgcaa tggacaagag ctttgaagct     9180

gttctcgtaa aaatctgtac tagcagaagt gacctgcaat cactactgct gaaatgcaca     9240

acccaccaca tcattgtgct cacattcact gtttggtttc tgtaaatgta caggaattgt     9300

ctgaaattag atatgatttt ttttttctcc atgaaggaat tcaattacac acctttgcct     9360

catgcacttc tttgtcattt ttgtcagact gcttctctcc tgcaatttgt ctcatggcaa     9420

caaaatataa tggagttctg ctgggaactt ccctactgcc ataccactat catctgcctc     9480

tgacattttg gacaaatgta ataaaatagg aggtattact ttcagagcag accttgtatg     9540

tatttacaaa acaagtggta cacaaaaaaa attgttcatc ccaccaacca atgcccatcc     9600

tgtccctgaa tagtagctgt cccccacagc cttgaccagt ttaggtcaac agttctgctt     9660

ctgtcccctc ccagctcctt gtaacccctc agcccccctt gctggcagga cagtatgaga     9720

agctgaaaaa ctagaatgtc ctagttcttt gcagtgctgc taatcaacaa ccaaaacagt     9780

ggtgtgttac caatattgtt gatatcacag catcatacca ttatgaagga agtaacccag     9840

ccaaaatcag gtcagcttgc taacaagaga actgtgcata agtttaagat gtgtgtgttc     9900

ctcagtacct taaaaaataa gtagtaacgt tcaaatgagt agaagagtag aactgagctt     9960

aaaacatctg tcagacaaca gtgaaccaac c                                    9991


<210>  123
<211>  9859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV4

<400>  123
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatggc cacctctgat     4440

gaagtcagga agaacctgat ggacatgttc agggacaggc aggccttctc tgaacacacc     4500

tggaagatgc tcctgtctgt gtgcagatcc tgggctgcct ggtgcaagct gaacggtacc     4560

catactcttt atgcccccgg tggatatgac attatgggat atctggacca gatcggcaac     4620

cggccaaacc cgcaggtgga actgggcccc gtggatacat cctgcgcctt gattctttgt     4680

gacctgaaac agaaagacac cccgatagtt tacgcgagtg aagccttcct ctacatgaca     4740

ggttacagca acgcagaggt gctgggccgg aattgccggt ttctgcaaag ccctgacggc     4800

atggtgaagc ccaagagcac ccggaagtac gtggatagta acacaatcaa tactatgcgc     4860

aaggcaatcg acaggaatgc cgaggtgcag gttgaagtag tcaattttaa aaagaatgga     4920

cagcgatttg ttaatttcct gactatgata cctgttaggg acgaaacagg cgagtatcga     4980

tactctatgg gattccagtg cgaaacagaa ggcggaagcg gtggcgtgcc caagaagaag     5040

aggaaagtct tcgaaggcag cggcgccacc aacttcagcc tgctgaagca ggccggcgac     5100

gtggaggaga accccggccc cttcgaagtg cccaagaaga agaggaaagt cggcggacat     5160

actctttatg cccccggtgg atatgacatt atgggatatc tgaggcagat caggaaccgg     5220

ccaaacccgc aggtggaact gggccccgtg gatacatcct gcgccttgat tctttgtgac     5280

ctgaaacaga aagacacccc gatagtttac gcgagtgaag ccttcctcta catgacaggt     5340

tacagcaacg cagaggtgct gggccggaat tgccggtttc tgcaaagccc tgacggcatg     5400

gtgaagccca agagcacccg gaagtacgtg gatagtaaca caatcaatac tatgcgcaag     5460

gcaatcgaca ggaatgccga ggtgcaggtt gaagtagtca attttaaaaa gaatggacag     5520

cgatttgtta atttcctgac tatgatacct gttagggacg aaacaggcga gtatcgatac     5580

tctatgggat tccagtgcga aacagaaggt accaacagga aatggttccc tgctgaacct     5640

gaggatgtga gggactacct cctgtacctg caagccagag gcctggctgt gaagaccatc     5700

caacagcacc tgggccagct caacatgctg cacaggagat ctggcctgcc tcgcccttct     5760

gactccaatg ctgtgtccct ggtgatgagg agaatcagaa aggagaatgt ggatgctggg     5820

gagagagcca agcaggccct ggcctttgaa cgcactgact ttgaccaagt cagatccctg     5880

atggagaact ctgacagatg ccaggacatc aggaacctgg ccttcctggg cattgcctac     5940

aacaccctgc tgcgcattgc cgaaattgcc agaatcagag tgaaggacat ctcccgcacc     6000

gatggtggga gaatgctgat ccacattggc aggaccaaga ccctggtgtc cacagctggt     6060

gtggagaagg ccctgtccct gggggttacc aagctggtgg agagatggat ctctgtgtct     6120

ggtgtggctg atgaccccaa caactacctg ttctgccggg tcagaaagaa tggtgtggct     6180

gccccttctg ccacctccca actgtccacc cgggccctgg aagggatctt tgaggccacc     6240

caccgcctga tctatggtgc caaggatgac tctgggcaga gatacctggc ctggtctggc     6300

cactctgcca gagtgggtgc tgccagggac atggccaggg ctggtgtgtc catccctgaa     6360

atcatgcagg ctggtggctg gaccaatgtg aacattgtga tgaactacat cagaaacctg     6420

gactctgaga ctggggccat ggtgaggctg ctcgaagatg gggactaatt aattaactcc     6480

tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg gccaatgccc tggctcacaa     6540

ataccactga gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     6600

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     6660

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     6720

gtatttggtt tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg     6780

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     6840

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     6900

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     6960

actcccagtc atagctgtcc ctcttctctt atggagatca taacttcgta taatgtatgc     7020

tatacgaagt tatacgcgtg ccaccatggt gagcaagggc gaggaggata acatggccat     7080

catcaaggag ttcatgcgct tcaaggtgca catggagggc tccgtgaacg gccacgagtt     7140

cgagatcgag ggcgagggcg agggccgccc ctacgagggc acccagaccg ccaagctgaa     7200

ggtgaccaag ggtggccccc tgcccttcgc ctgggacatc ctgtcccctc agttcatgta     7260

cggctccaag gcctacgtga agcaccccgc cgacatcccc gactacttga agctgtcctt     7320

ccccgagggc ttcaagtggg agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt     7380

gacccaggac tcctccctgc aggacggcga gttcatctac aaggtgaagc tgcgcggcac     7440

caacttcccc tccgacggcc ccgtaatgca gaagaagacc atgggctggg aggcctcctc     7500

cgagcggatg taccccgagg acggcgccct gaagggcgag atcaagcaga ggctgaagct     7560

gaaggacggc ggccactacg acgctgaggt caagaccacc tacaaggcca agaagcccgt     7620

gcagctgccc ggcgcctaca acgtcaacat caagttggac atcacctccc acaacgagga     7680

ctacaccatc gtggaacagt acgaacgcgc cgagggccgc cactccaccg gcggcatgga     7740

cgagctgtac aagtgtggcg gctagacgcg tactcctcag gtgcaggctg cctatcagaa     7800

ggtggtggct ggtgtggcca atgccctggc tcacaaatac cactgagatc tttttccctc     7860

tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag     7920

gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac     7980

atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac     8040

atatgcccat atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat     8100

gaaacagccc cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat     8160

tttttttata ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca     8220

tgttttacta gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct     8280

tctcttatgg agatcgccgt ttccacattc ttttctcatc cttcttctcc tgttttctct     8340

gcatcaaggt cagcacgata gcactgtctc tctatgctta gggagaggcc tgtcctgtac     8400

atcccgtgcc cccacaagat gcctactaca acaacatctt ctgcatgtcc tgcatagcag     8460

tgttgggaga atgtgcacta cttccactct tctgatttct attttatgtg tttgctttat     8520

accagtgttg ccatttggga attaatacat ggttgatcaa atcaattgca tcacagctgt     8580

atcctgtatc agaggaacat tatcaaagct tttgttgctg tatttggtat ctgacctgca     8640

gataaacatg ttttaggaag gttttgcaaa agtagctgtg aaatgagctg gtgttgtgat     8700

ttaacctgac aggcagctaa acagtatacc acagagctat tcacctactt tccctcagtg     8760

ggaaaaggga agagaactga gggggggggg aataaataag taaataacaa aataaaactc     8820

atggattaag aaaaagactt tgtactggaa tggatgagaa gaataatagt aatgataata     8880

atatgtcact ctgaaagtaa tgcctcttat ttctgtggag actacaaaca tacaaagagc     8940

acaacattcc atagagcaaa ttctcagtta cagaatgcta tttttttttt caacacagtc     9000

aaaatcatta attttttttt gcctgcaatg gacaagagct ttgaagctgt tctcgtaaaa     9060

atctgtacta gcagaagtga cctgcaatca ctactgctga aatgcacaac ccaccacatc     9120

attgtgctca cattcactgt ttggtttctg taaatgtaca ggaattgtct gaaattagat     9180

atgatttttt ttttctccat gaaggaattc aattacacac ctttgcctca tgcacttctt     9240

tgtcattttt gtcagactgc ttctctcctg caatttgtct catggcaaca aaatataatg     9300

gagttctgct gggaacttcc ctactgccat accactatca tctgcctctg acattttgga     9360

caaatgtaat aaaataggag gtattacttt cagagcagac cttgtatgta tttacaaaac     9420

aagtggtaca caaaaaaaat tgttcatccc accaaccaat gcccatcctg tccctgaata     9480

gtagctgtcc cccacagcct tgaccagttt aggtcaacag ttctgcttct gtcccctccc     9540

agctccttgt aacccctcag ccccccttgc tggcaggaca gtatgagaag ctgaaaaact     9600

agaatgtcct agttctttgc agtgctgcta atcaacaacc aaaacagtgg tgtgttacca     9660

atattgttga tatcacagca tcataccatt atgaaggaag taacccagcc aaaatcaggt     9720

cagcttgcta acaagagaac tgtgcataag tttaagatgt gtgtgttcct cagtacctta     9780

aaaaataagt agtaacgttc aaatgagtag aagagtagaa ctgagcttaa aacatctgtc     9840

agacaacagt gaaccaacc                                                  9859


<210>  124
<211>  11581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV5

<400>  124
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatgaa tggagctata     4440

ggaggtgacc ttttgctcaa ttttcctgac atgtcggtcc tagagcgcca aagggctcac     4500

ctcaagtacc tcaatcccac ctttgattct cctctcgccg gcttctttgc cgattcttca     4560

atgattaccg gcggcgagat ggacagctat ctttcgactg ccggtttgaa tcttccgatg     4620

atgtacggtg agacgacggt ggaaggtgat tcaagactct caatttcgcc ggaaacgacg     4680

cttgggactg gaaatttcaa gaaacggaag tttgatacag agactaagga ttgtaatgag     4740

aagaagaaga agatgacgat gaacagagat gacctagtag aagaaggaga agaagagaag     4800

tcgaaaataa cagagcaaaa caatgggagc acaaaaagca tcaagaagat gaaacacaaa     4860

gccaagaaag aagagaacaa tttctctaat gattcatcta aagtgacgaa ggaattggag     4920

aaaacggatt atattcatgg tggcggtggc tctggaggtg gtgggtccgg aggaggcggc     4980

cgccgaccaa gtgacagcaa tgctgtttca ctggttatgc ggcggatccg aaaagaaaac     5040

gttgatgccg gtgaacgtgc aaaacaggct ctagcgttcg aacgcactga tttcgaccag     5100

gttcgttcac tcatggaaaa tagcgatcgc tgccaggata tacgtaatct ggcatttctg     5160

gggattgctt ataacaccct gttacgtata gccgaaattg ccaggatcag ggttaaagat     5220

atctcacgta ctgacggtgg gagaatgtta atccatattg gcagaacgaa aacgctggtt     5280

agcaccgcag gtgtagagaa ggcacttagc ctgggggtaa ctaaactggt cgagcgatgg     5340

atttccgtct ctggtgtagc tgatgatccg aataactacc tgttttgccg ggtcagaaaa     5400

aatggtgttg ccgcgccatc tgccaccagc cagctatcaa ctcgcgccct ggaagggatt     5460

tttgaagcaa ctcatcgatt gatttacggc gctaaggatg actctggtca gagatacctg     5520

gcctggtctg gacacagtgc ccgtgtcgga gccgcgcgag atatggcccg cgctggagtt     5580

tcaataccgg agatcatgca agctggtggc tggaccaatg taaatattgt catgaactat     5640

atccgtaacc tggatagtga aacaggggca atggtgcgcc tgctggaaga tggcgattag     5700

cccgggtagg cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat     5760

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     5820

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     5880

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     5940

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     6000

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     6060

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     6120

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     6180

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc     6240

cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaaccatg     6300

cctaaaaaga agcgtaaagt catgaagatg aagatggaca aaaagactat agtttggttt     6360

agaagagacc taaggattga ggataatcct gcattagcag cagctgctca cgaaggatct     6420

gtttttcctg tcttcatttg gtgtcctgaa gaagaaggac agttttatcc tggaagagct     6480

tcaagatggt ggatgaaaca atcacttgct cacttatctc aatccttgaa ggctcttgga     6540

tctgacctca ctttaatcaa aacccacaac acgatttcag cgatcttgga ttgtatccgc     6600

gttaccggtg ctacaaaagt cgtctttaac cacctctatg atcctgtttc gttagttcgg     6660

gaccataccg taaaggagaa gctggtggaa cgtgggatct ctgtgcaaag ctacaatgga     6720

gatctattgt atgaaccgtg ggagatatac tgcgaaaagg gcaaaccttt tacgagtttc     6780

aattcttact ggaagaaatg cttagatatg tcgattgaat ccgttatgct tcctcctcct     6840

tggcggttga tgccaataac tgcagcggct gaagcgattt gggcgtgttc gattgaagaa     6900

ctagggctgg agaatgaggc cgagaaaccg agcaatgcgt tgttaactag agcttggtct     6960

ccaggatgga gcaatgctga taagttacta aatgagttca tcgagaagca gttgatagat     7020

tatgcaaaga acagcaagaa agttgttggg aattctactt cactactttc tccgtatctc     7080

catttcgggg aaataagcgt cagacacgtt ttccagtgtg cccggatgaa acaaattata     7140

tgggcaagag ataagaacag tgaaggagaa gaaagtgcag atctttttct taggggaatc     7200

ggtttaagag agtattctcg gtatatatgt ttcaacttcc cgtttactca cgagcaatcg     7260

ttgttgagtc atcttcggtt tttcccttgg gatgctgatg ttgataagtt caaggcctgg     7320

agacaaggca ggaccggtta tccgttggtg gatgccggaa tgagagagtt ttgggctacc     7380

ggatggatgc ataacagaat aagagtgatt gtttcaagct ttgctgtgaa gtttcttctc     7440

cttccatgga aatggggaat gaagtatttc tgggatacac ttttggatgc tgatttggaa     7500

tgtgacatcc ttggctggca gtatatctct gggagtatcc ccgatggcca cgagcttgat     7560

cgcttggaca atcccgcgtt acaaggcgcc aaatatgacc cagaaggtga gtacataagg     7620

caatggcttc ccgagcttgc gagattgcca actgaatgga tccatcatcc atgggacgct     7680

cctttaaccg tactcaaagc ttctggtgtg gaactcggaa caaactatgc gaaacccatt     7740

gtagacatcg acacagctcg tgagctacta gctaaagcta tttcaagaac ccgtgaagca     7800

cagatcatga tcggagcagc acctgatgag attgtagcag atagcttcga ggccttaggg     7860

gctaatacca ttaaagaacc tggtctttgc ccatctgtgt cttctaatga ccaacaagta     7920

ccttcggctg ttggtggcgg tggctctgga ggtggtgggt ccggaggagg cggccgcacg     7980

agtgatgagg ttcgcaagaa cctgatggac atgttcaggg atcgccaggc gttttctgag     8040

catacctgga aaatgcttct gtccgtttgc cggtcgtggg cggcatggtg caagttgaat     8100

aaccggaaat ggtttcccgc agaacctgaa gatgttcgcg attatcttct atatcttcag     8160

gcgcgcggtc tggcagtaaa aactatccag caacatttgg gccagctaaa catgcttcat     8220

cgtcggtccg ggctgtaatt aattaactcc tcaggtgcag gctgcctatc agaaggtggt     8280

ggctggtgtg gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa     8340

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     8400

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg     8460

gagggcaaat catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc     8520

ccatatgctg gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca     8580

gccccctgct gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt     8640

tatattttgt tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt     8700

actagccaga tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt     8760

atggagatca taacttcgta taatgtatgc tatacgaagt tatacgcgtg ccaccatgga     8820

tcattcccag tgccttgtga ctatatacgc cgcggcggtg ctgctggggc tccggctgca     8880

gcagggctcc tgccagcact acctgcacat ccgcccggct cccagcgaca acctgcccct     8940

ggtggatcta atcgagcacc cggaccctat ctttgacccc aaggagaagg atcttaacga     9000

gaccttgcta aggagcctca tgggaggaca cttcgaccct aactttatgg ctatgtccct     9060

gcccgaggac cggctcgggg tagacgatct ggccgagctg gacttgctgc tgcggcagag     9120

accctcggga gcgatgcccg gcgaaatcaa ggggctggag ttctacgacg ggctgcagcc     9180

gggcaagaag cacaggctga gcaagaagct gcgcaggaag ctgcagatgt ggctctggtc     9240

ccagaccttc tgcccggtcc tatacacgtg gaacgatctc ggcagccgct tttggccccg     9300

gtacgtcaaa gtgggcagct gctacagtaa aaggtcttgc tctgtcccag aaggcatggt     9360

ctgcaaacct gccaagtccg tgcatttaac gatcctgagg tggcggtgcc agcggcgggg     9420

cgggcagcgg tgcacgtgga tccccatcca gtaccccatc atcgcggagt gcaagtgctc     9480

ctgctagacg cgtactcctc aggtgcaggc tgcctatcag aaggtggtgg ctggtgtggc     9540

caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa attatgggga     9600

catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc     9660

aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga gggcaaatca     9720

tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc atatgctggc     9780

tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc cccctgctgt     9840

ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta tattttgttt     9900

tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac tagccagatt     9960

tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat ggagatcgcc    10020

gtttccacat tcttttctca tccttcttct cctgttttct ctgcatcaag gtcagcacga    10080

tagcactgtc tctctatgct tagggagagg cctgtcctgt acatcccgtg cccccacaag    10140

atgcctacta caacaacatc ttctgcatgt cctgcatagc agtgttggga gaatgtgcac    10200

tacttccact cttctgattt ctattttatg tgtttgcttt ataccagtgt tgccatttgg    10260

gaattaatac atggttgatc aaatcaattg catcacagct gtatcctgta tcagaggaac    10320

attatcaaag cttttgttgc tgtatttggt atctgacctg cagataaaca tgttttagga    10380

aggttttgca aaagtagctg tgaaatgagc tggtgttgtg atttaacctg acaggcagct    10440

aaacagtata ccacagagct attcacctac tttccctcag tgggaaaagg gaagagaact    10500

gagggggggg ggaataaata agtaaataac aaaataaaac tcatggatta agaaaaagac    10560

tttgtactgg aatggatgag aagaataata gtaatgataa taatatgtca ctctgaaagt    10620

aatgcctctt atttctgtgg agactacaaa catacaaaga gcacaacatt ccatagagca    10680

aattctcagt tacagaatgc tatttttttt ttcaacacag tcaaaatcat taattttttt    10740

ttgcctgcaa tggacaagag ctttgaagct gttctcgtaa aaatctgtac tagcagaagt    10800

gacctgcaat cactactgct gaaatgcaca acccaccaca tcattgtgct cacattcact    10860

gtttggtttc tgtaaatgta caggaattgt ctgaaattag atatgatttt ttttttctcc    10920

atgaaggaat tcaattacac acctttgcct catgcacttc tttgtcattt ttgtcagact    10980

gcttctctcc tgcaatttgt ctcatggcaa caaaatataa tggagttctg ctgggaactt    11040

ccctactgcc ataccactat catctgcctc tgacattttg gacaaatgta ataaaatagg    11100

aggtattact ttcagagcag accttgtatg tatttacaaa acaagtggta cacaaaaaaa    11160

attgttcatc ccaccaacca atgcccatcc tgtccctgaa tagtagctgt cccccacagc    11220

cttgaccagt ttaggtcaac agttctgctt ctgtcccctc ccagctcctt gtaacccctc    11280

agcccccctt gctggcagga cagtatgaga agctgaaaaa ctagaatgtc ctagttcttt    11340

gcagtgctgc taatcaacaa ccaaaacagt ggtgtgttac caatattgtt gatatcacag    11400

catcatacca ttatgaagga agtaacccag ccaaaatcag gtcagcttgc taacaagaga    11460

actgtgcata agtttaagat gtgtgtgttc ctcagtacct taaaaaataa gtagtaacgt    11520

tcaaatgagt agaagagtag aactgagctt aaaacatctg tcagacaaca gtgaaccaac    11580

c                                                                    11581


<210>  125
<211>  11566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV6

<400>  125
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatgaa tggagctata     4440

ggaggtgacc ttttgctcaa ttttcctgac atgtcggtcc tagagcgcca aagggctcac     4500

ctcaagtacc tcaatcccac ctttgattct cctctcgccg gcttctttgc cgattcttca     4560

atgattaccg gcggcgagat ggacagctat ctttcgactg ccggtttgaa tcttccgatg     4620

atgtacggtg agacgacggt ggaaggtgat tcaagactct caatttcgcc ggaaacgacg     4680

cttgggactg gaaatttcaa gaaacggaag tttgatacag agactaagga ttgtaatgag     4740

aagaagaaga agatgacgat gaacagagat gacctagtag aagaaggaga agaagagaag     4800

tcgaaaataa cagagcaaaa caatgggagc acaaaaagca tcaagaagat gaaacacaaa     4860

gccaagaaag aagagaacaa tttctctaat gattcatcta aagtgacgaa ggaattggag     4920

aaaacggatt atattcatgg tggcggtggc tctggaggtg gtgggtccgg aggaggcggc     4980

cgccgaccaa gtgacagcaa tgctgtttca ctggttatgc ggcggatccg aaaagaaaac     5040

gttgatgccg gtgaacgtgc aaaacaggct ctagcgttcg aacgcactga tttcgaccag     5100

gttcgttcac tcatggaaaa tagcgatcgc tgccaggata tacgtaatct ggcatttctg     5160

gggattgctt ataacaccct gttacgtata gccgaaattg ccaggatcag ggttaaagat     5220

atctcacgta ctgacggtgg gagaatgtta atccatattg gcagaacgaa aacgctggtt     5280

agcaccgcag gtgtagagaa ggcacttagc ctgggggtaa ctaaactggt cgagcgatgg     5340

atttccgtct ctggtgtagc tgatgatccg aataactacc tgttttgccg ggtcagaaaa     5400

aatggtgttg ccgcgccatc tgccaccagc cagctatcaa ctcgcgccct ggaagggatt     5460

tttgaagcaa ctcatcgatt gatttacggc gctaaggatg actctggtca gagatacctg     5520

gcctggtctg gacacagtgc ccgtgtcgga gccgcgcgag atatggcccg cgctggagtt     5580

tcaataccgg agatcatgca agctggtggc tggaccaatg taaatattgt catgaactat     5640

atccgtaacc tggatagtga aacaggggca atggtgcgcc tgctggaaga tggcgattag     5700

cccgggtagg cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat     5760

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     5820

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     5880

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     5940

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     6000

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     6060

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     6120

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     6180

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc     6240

cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaaccatg     6300

cctaaaaaga agcgtaaagt catgaagatg aagatggaca aaaagactat agtttggttt     6360

agaagagacc taaggattga ggataatcct gcattagcag cagctgctca cgaaggatct     6420

gtttttcctg tcttcatttg gtgtcctgaa gaagaaggac agttttatcc tggaagagct     6480

tcaagatggt ggatgaaaca atcacttgct cacttatctc aatccttgaa ggctcttgga     6540

tctgacctca ctttaatcaa aacccacaac acgatttcag cgatcttgga ttgtatccgc     6600

gttaccggtg ctacaaaagt cgtctttaac cacctctatg atcctgtttc gttagttcgg     6660

gaccataccg taaaggagaa gctggtggaa cgtgggatct ctgtgcaaag ctacaatgga     6720

gatctattgt atgaaccgtg ggagatatac tgcgaaaagg gcaaaccttt tacgagtttc     6780

aattcttact ggaagaaatg cttagatatg tcgattgaat ccgttatgct tcctcctcct     6840

tggcggttga tgccaataac tgcagcggct gaagcgattt gggcgtgttc gattgaagaa     6900

ctagggctgg agaatgaggc cgagaaaccg agcaatgcgt tgttaactag agcttggtct     6960

ccaggatgga gcaatgctga taagttacta aatgagttca tcgagaagca gttgatagat     7020

tatgcaaaga acagcaagaa agttgttggg aattctactt cactactttc tccgtatctc     7080

catttcgggg aaataagcgt cagacacgtt ttccagtgtg cccggatgaa acaaattata     7140

tgggcaagag ataagaacag tgaaggagaa gaaagtgcag atctttttct taggggaatc     7200

ggtttaagag agtattctcg gtatatatgt ttcaacttcc cgtttactca cgagcaatcg     7260

ttgttgagtc atcttcggtt tttcccttgg gatgctgatg ttgataagtt caaggcctgg     7320

agacaaggca ggaccggtta tccgttggtg gatgccggaa tgagagagtt ttgggctacc     7380

ggatggatgc ataacagaat aagagtgatt gtttcaagct ttgctgtgaa gtttcttctc     7440

cttccatgga aatggggaat gaagtatttc tgggatacac ttttggatgc tgatttggaa     7500

tgtgacatcc ttggctggca gtatatctct gggagtatcc ccgatggcca cgagcttgat     7560

cgcttggaca atcccgcgtt acaaggcgcc aaatatgacc cagaaggtga gtacataagg     7620

caatggcttc ccgagcttgc gagattgcca actgaatgga tccatcatcc atgggacgct     7680

cctttaaccg tactcaaagc ttctggtgtg gaactcggaa caaactatgc gaaacccatt     7740

gtagacatcg acacagctcg tgagctacta gctaaagcta tttcaagaac ccgtgaagca     7800

cagatcatga tcggagcagc acctgatgag attgtagcag atagcttcga ggccttaggg     7860

gctaatacca ttaaagaacc tggtctttgc ccatctgtgt cttctaatga ccaacaagta     7920

ccttcggctg ttggtggcgg tggctctgga ggtggtgggt ccggaggagg cggccgcacg     7980

agtgatgagg ttcgcaagaa cctgatggac atgttcaggg atcgccaggc gttttctgag     8040

catacctgga aaatgcttct gtccgtttgc cggtcgtggg cggcatggtg caagttgaat     8100

aaccggaaat ggtttcccgc agaacctgaa gatgttcgcg attatcttct atatcttcag     8160

gcgcgcggtc tggcagtaaa aactatccag caacatttgg gccagctaaa catgcttcat     8220

cgtcggtccg ggctgtaatt aattaactcc tcaggtgcag gctgcctatc agaaggtggt     8280

ggctggtgtg gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa     8340

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     8400

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg     8460

gagggcaaat catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc     8520

ccatatgctg gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca     8580

gccccctgct gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt     8640

tatattttgt tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt     8700

actagccaga tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt     8760

atggagatca taacttcgta taatgtatgc tatacgaagt tatacgcgtg ccaccatgga     8820

tcctgatgat gttgttgatt cttctaaatc ttttgtgatg gaaaactttt cttcgtacca     8880

cgggactaaa cctggttatg tagattccat tcaaaaaggt atacaaaagc caaaatctgg     8940

tacacaagga aattatgacg atgattggaa agggttttat agtaccgaca ataaatacga     9000

cgctgcggga tactctgtag ataatgaaaa cccgctctct ggaaaagctg gaggcgtggt     9060

caaagtgacg tatccaggac tgacgaaggt tctcgcacta aaagtggata atgccgaaac     9120

tattaagaaa gagttaggtt taagtctcac tgaaccgttg atggagcaag tcggaacgga     9180

agagtttatc aaaaggttcg gtgatggtgc ttcgcgtgta gtgctcagcc ttcccttcgc     9240

tgaggggagt tctagcgttg aatatattaa taactgggaa caggcgaaag cgttaagcgt     9300

agaacttgag attaattttg aaacccgtgg aaaacgtggc caagatgcga tgtatgagta     9360

tatggctcaa gcctgtgcag gaaatcgtgt caggcgatct ctttgtgaag gaaccttact     9420

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaacgcgtac     9480

tcctcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg ccctggctca     9540

caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct     9600

tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     9660

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa     9720

tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca tgaacaaagg     9780

ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt ccttattcca     9840

tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt tatttttttc     9900

tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc tcctctcctg     9960

actactccca gtcatagctg tccctcttct cttatggaga tcgccgtttc cacattcttt    10020

tctcatcctt cttctcctgt tttctctgca tcaaggtcag cacgatagca ctgtctctct    10080

atgcttaggg agaggcctgt cctgtacatc ccgtgccccc acaagatgcc tactacaaca    10140

acatcttctg catgtcctgc atagcagtgt tgggagaatg tgcactactt ccactcttct    10200

gatttctatt ttatgtgttt gctttatacc agtgttgcca tttgggaatt aatacatggt    10260

tgatcaaatc aattgcatca cagctgtatc ctgtatcaga ggaacattat caaagctttt    10320

gttgctgtat ttggtatctg acctgcagat aaacatgttt taggaaggtt ttgcaaaagt    10380

agctgtgaaa tgagctggtg ttgtgattta acctgacagg cagctaaaca gtataccaca    10440

gagctattca cctactttcc ctcagtggga aaagggaaga gaactgaggg gggggggaat    10500

aaataagtaa ataacaaaat aaaactcatg gattaagaaa aagactttgt actggaatgg    10560

atgagaagaa taatagtaat gataataata tgtcactctg aaagtaatgc ctcttatttc    10620

tgtggagact acaaacatac aaagagcaca acattccata gagcaaattc tcagttacag    10680

aatgctattt tttttttcaa cacagtcaaa atcattaatt tttttttgcc tgcaatggac    10740

aagagctttg aagctgttct cgtaaaaatc tgtactagca gaagtgacct gcaatcacta    10800

ctgctgaaat gcacaaccca ccacatcatt gtgctcacat tcactgtttg gtttctgtaa    10860

atgtacagga attgtctgaa attagatatg attttttttt tctccatgaa ggaattcaat    10920

tacacacctt tgcctcatgc acttctttgt catttttgtc agactgcttc tctcctgcaa    10980

tttgtctcat ggcaacaaaa tataatggag ttctgctggg aacttcccta ctgccatacc    11040

actatcatct gcctctgaca ttttggacaa atgtaataaa ataggaggta ttactttcag    11100

agcagacctt gtatgtattt acaaaacaag tggtacacaa aaaaaattgt tcatcccacc    11160

aaccaatgcc catcctgtcc ctgaatagta gctgtccccc acagccttga ccagtttagg    11220

tcaacagttc tgcttctgtc ccctcccagc tccttgtaac ccctcagccc cccttgctgg    11280

caggacagta tgagaagctg aaaaactaga atgtcctagt tctttgcagt gctgctaatc    11340

aacaaccaaa acagtggtgt gttaccaata ttgttgatat cacagcatca taccattatg    11400

aaggaagtaa cccagccaaa atcaggtcag cttgctaaca agagaactgt gcataagttt    11460

aagatgtgtg tgttcctcag taccttaaaa aataagtagt aacgttcaaa tgagtagaag    11520

agtagaactg agcttaaaac atctgtcaga caacagtgaa ccaacc                   11566


<210>  126
<211>  11761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV7

<400>  126
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatgaa tggagctata     4440

ggaggtgacc ttttgctcaa ttttcctgac atgtcggtcc tagagcgcca aagggctcac     4500

ctcaagtacc tcaatcccac ctttgattct cctctcgccg gcttctttgc cgattcttca     4560

atgattaccg gcggcgagat ggacagctat ctttcgactg ccggtttgaa tcttccgatg     4620

atgtacggtg agacgacggt ggaaggtgat tcaagactct caatttcgcc ggaaacgacg     4680

cttgggactg gaaatttcaa gaaacggaag tttgatacag agactaagga ttgtaatgag     4740

aagaagaaga agatgacgat gaacagagat gacctagtag aagaaggaga agaagagaag     4800

tcgaaaataa cagagcaaaa caatgggagc acaaaaagca tcaagaagat gaaacacaaa     4860

gccaagaaag aagagaacaa tttctctaat gattcatcta aagtgacgaa ggaattggag     4920

aaaacggatt atattcatgg tggcggtggc tctggaggtg gtgggtccgg aggaggcggc     4980

cgccgaccaa gtgacagcaa tgctgtttca ctggttatgc ggcggatccg aaaagaaaac     5040

gttgatgccg gtgaacgtgc aaaacaggct ctagcgttcg aacgcactga tttcgaccag     5100

gttcgttcac tcatggaaaa tagcgatcgc tgccaggata tacgtaatct ggcatttctg     5160

gggattgctt ataacaccct gttacgtata gccgaaattg ccaggatcag ggttaaagat     5220

atctcacgta ctgacggtgg gagaatgtta atccatattg gcagaacgaa aacgctggtt     5280

agcaccgcag gtgtagagaa ggcacttagc ctgggggtaa ctaaactggt cgagcgatgg     5340

atttccgtct ctggtgtagc tgatgatccg aataactacc tgttttgccg ggtcagaaaa     5400

aatggtgttg ccgcgccatc tgccaccagc cagctatcaa ctcgcgccct ggaagggatt     5460

tttgaagcaa ctcatcgatt gatttacggc gctaaggatg actctggtca gagatacctg     5520

gcctggtctg gacacagtgc ccgtgtcgga gccgcgcgag atatggcccg cgctggagtt     5580

tcaataccgg agatcatgca agctggtggc tggaccaatg taaatattgt catgaactat     5640

atccgtaacc tggatagtga aacaggggca atggtgcgcc tgctggaaga tggcgattag     5700

cccgggtagg cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat     5760

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     5820

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     5880

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     5940

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     6000

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     6060

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     6120

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     6180

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc     6240

cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaaccatg     6300

cctaaaaaga agcgtaaagt catgaagatg aagatggaca aaaagactat agtttggttt     6360

agaagagacc taaggattga ggataatcct gcattagcag cagctgctca cgaaggatct     6420

gtttttcctg tcttcatttg gtgtcctgaa gaagaaggac agttttatcc tggaagagct     6480

tcaagatggt ggatgaaaca atcacttgct cacttatctc aatccttgaa ggctcttgga     6540

tctgacctca ctttaatcaa aacccacaac acgatttcag cgatcttgga ttgtatccgc     6600

gttaccggtg ctacaaaagt cgtctttaac cacctctatg atcctgtttc gttagttcgg     6660

gaccataccg taaaggagaa gctggtggaa cgtgggatct ctgtgcaaag ctacaatgga     6720

gatctattgt atgaaccgtg ggagatatac tgcgaaaagg gcaaaccttt tacgagtttc     6780

aattcttact ggaagaaatg cttagatatg tcgattgaat ccgttatgct tcctcctcct     6840

tggcggttga tgccaataac tgcagcggct gaagcgattt gggcgtgttc gattgaagaa     6900

ctagggctgg agaatgaggc cgagaaaccg agcaatgcgt tgttaactag agcttggtct     6960

ccaggatgga gcaatgctga taagttacta aatgagttca tcgagaagca gttgatagat     7020

tatgcaaaga acagcaagaa agttgttggg aattctactt cactactttc tccgtatctc     7080

catttcgggg aaataagcgt cagacacgtt ttccagtgtg cccggatgaa acaaattata     7140

tgggcaagag ataagaacag tgaaggagaa gaaagtgcag atctttttct taggggaatc     7200

ggtttaagag agtattctcg gtatatatgt ttcaacttcc cgtttactca cgagcaatcg     7260

ttgttgagtc atcttcggtt tttcccttgg gatgctgatg ttgataagtt caaggcctgg     7320

agacaaggca ggaccggtta tccgttggtg gatgccggaa tgagagagtt ttgggctacc     7380

ggatggatgc ataacagaat aagagtgatt gtttcaagct ttgctgtgaa gtttcttctc     7440

cttccatgga aatggggaat gaagtatttc tgggatacac ttttggatgc tgatttggaa     7500

tgtgacatcc ttggctggca gtatatctct gggagtatcc ccgatggcca cgagcttgat     7560

cgcttggaca atcccgcgtt acaaggcgcc aaatatgacc cagaaggtga gtacataagg     7620

caatggcttc ccgagcttgc gagattgcca actgaatgga tccatcatcc atgggacgct     7680

cctttaaccg tactcaaagc ttctggtgtg gaactcggaa caaactatgc gaaacccatt     7740

gtagacatcg acacagctcg tgagctacta gctaaagcta tttcaagaac ccgtgaagca     7800

cagatcatga tcggagcagc acctgatgag attgtagcag atagcttcga ggccttaggg     7860

gctaatacca ttaaagaacc tggtctttgc ccatctgtgt cttctaatga ccaacaagta     7920

ccttcggctg ttggtggcgg tggctctgga ggtggtgggt ccggaggagg cggccgcacg     7980

agtgatgagg ttcgcaagaa cctgatggac atgttcaggg atcgccaggc gttttctgag     8040

catacctgga aaatgcttct gtccgtttgc cggtcgtggg cggcatggtg caagttgaat     8100

aaccggaaat ggtttcccgc agaacctgaa gatgttcgcg attatcttct atatcttcag     8160

gcgcgcggtc tggcagtaaa aactatccag caacatttgg gccagctaaa catgcttcat     8220

cgtcggtccg ggctgtaatt aattaactcc tcaggtgcag gctgcctatc agaaggtggt     8280

ggctggtgtg gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa     8340

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     8400

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg     8460

gagggcaaat catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc     8520

ccatatgctg gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca     8580

gccccctgct gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt     8640

tatattttgt tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt     8700

actagccaga tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt     8760

atggagatca taacttcgta taatgtatgc tatacgaagt tatacgcgtg ccaccatgat     8820

gacagacata aaagatggac cacgctcagg ggaagatgta tcagctgcaa gatctttccc     8880

tggttccaaa ggaatgaact tacctgctag caagtctgtg gcctctggaa ttctgcctga     8940

tgacagttac agaatggatt atccagagat aggagtatgt gttataataa acaataagaa     9000

cttccaccga gataccggac tgtcatctcg ttcaggcacg gatgcagatg ctgcaagtgt     9060

cagagaagtt tttatgaagc tgggatataa agtcaagctt aacaatgatc tgtcaagcag     9120

agatattttt aagctattga aaaatgtttc tgaagaagat cacagcaagc gaagcagttt     9180

tgtttgtgtg ttgctaagcc atggcgatga aggactcttc tatggtacag atggccctct     9240

tgaactgaaa gtactaacca gccttttcag aggtgacaag tgcagaagtc tagcagggaa     9300

acccaaactc tttttcattc aggcctgtag aggaacagaa ttagattctg gtattgaagc     9360

agccagtgga ccagatgaaa cagtgtgtca aaaaatacct gtagaagcag acttcctgta     9420

tgcatattct actgctccag gctactactc ctggaggaac gcagctgaag gctcctggtt     9480

tattcagtct ctgtgtagga tgctgaagga acacgccagg aaacttgaac tcatgcagat     9540

tttaactcgt gtaaatcgca gagtggcaga atatgaatcc tgctccactc gacaggattt     9600

caatgcaaag aaacagattc catgcattga gtctatgctt accaaagaat tctactttcc     9660

ttgctaaacg cgtactcctc aggtgcaggc tgcctatcag aaggtggtgg ctggtgtggc     9720

caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa attatgggga     9780

catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc     9840

aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga gggcaaatca     9900

tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc atatgctggc     9960

tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc cccctgctgt    10020

ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta tattttgttt    10080

tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac tagccagatt    10140

tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat ggagatcgcc    10200

gtttccacat tcttttctca tccttcttct cctgttttct ctgcatcaag gtcagcacga    10260

tagcactgtc tctctatgct tagggagagg cctgtcctgt acatcccgtg cccccacaag    10320

atgcctacta caacaacatc ttctgcatgt cctgcatagc agtgttggga gaatgtgcac    10380

tacttccact cttctgattt ctattttatg tgtttgcttt ataccagtgt tgccatttgg    10440

gaattaatac atggttgatc aaatcaattg catcacagct gtatcctgta tcagaggaac    10500

attatcaaag cttttgttgc tgtatttggt atctgacctg cagataaaca tgttttagga    10560

aggttttgca aaagtagctg tgaaatgagc tggtgttgtg atttaacctg acaggcagct    10620

aaacagtata ccacagagct attcacctac tttccctcag tgggaaaagg gaagagaact    10680

gagggggggg ggaataaata agtaaataac aaaataaaac tcatggatta agaaaaagac    10740

tttgtactgg aatggatgag aagaataata gtaatgataa taatatgtca ctctgaaagt    10800

aatgcctctt atttctgtgg agactacaaa catacaaaga gcacaacatt ccatagagca    10860

aattctcagt tacagaatgc tatttttttt ttcaacacag tcaaaatcat taattttttt    10920

ttgcctgcaa tggacaagag ctttgaagct gttctcgtaa aaatctgtac tagcagaagt    10980

gacctgcaat cactactgct gaaatgcaca acccaccaca tcattgtgct cacattcact    11040

gtttggtttc tgtaaatgta caggaattgt ctgaaattag atatgatttt ttttttctcc    11100

atgaaggaat tcaattacac acctttgcct catgcacttc tttgtcattt ttgtcagact    11160

gcttctctcc tgcaatttgt ctcatggcaa caaaatataa tggagttctg ctgggaactt    11220

ccctactgcc ataccactat catctgcctc tgacattttg gacaaatgta ataaaatagg    11280

aggtattact ttcagagcag accttgtatg tatttacaaa acaagtggta cacaaaaaaa    11340

attgttcatc ccaccaacca atgcccatcc tgtccctgaa tagtagctgt cccccacagc    11400

cttgaccagt ttaggtcaac agttctgctt ctgtcccctc ccagctcctt gtaacccctc    11460

agcccccctt gctggcagga cagtatgaga agctgaaaaa ctagaatgtc ctagttcttt    11520

gcagtgctgc taatcaacaa ccaaaacagt ggtgtgttac caatattgtt gatatcacag    11580

catcatacca ttatgaagga agtaacccag ccaaaatcag gtcagcttgc taacaagaga    11640

actgtgcata agtttaagat gtgtgtgttc ctcagtacct taaaaaataa gtagtaacgt    11700

tcaaatgagt agaagagtag aactgagctt aaaacatctg tcagacaaca gtgaaccaac    11760

c                                                                    11761


<210>  127
<211>  11629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting Vector TV8

<400>  127
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcacaca     1500

tttccccgaa aagtgccacc tgggtcgaca ttgattattg actagttatt aatagtaatc     1560

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     1620

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     1680

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     1740

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     1800

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     1860

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc     1920

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt     1980

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg     2040

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa     2100

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta     2160

taaaaagcga agcgcgcggc gggcggggag tcgctgcgac gctgccttcg ccccgtgccc     2220

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag     2280

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg     2340

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     2400

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     2460

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     2520

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     2580

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     2640

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     2700

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     2760

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     2820

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     2880

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     2940

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     3000

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     3060

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     3120

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     3180

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaataa cttcgtataa     3240

tgtatgctat acgaagttat accggtgaag ttcctattcc gaagttccta ttctctagaa     3300

agtataggaa cttcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3360

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3420

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3480

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3540

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3600

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3660

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3720

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3780

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3840

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3900

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     3960

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4020

tggacgagct gtacaagggc agcggcgcca ccaacttcag cctgctgaag caggccggcg     4080

acgtggagga gaaccccggc cccgctagct aaagcggccg ccaattccta gagctcgctg     4140

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4200

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4260

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4320

gggggaggat tgggaagaca atagcaggca tgctggggag aagttcctat tccgaagttc     4380

ctattctcta gaaagtatag gaacttcgct agcaccggtg ccaccatgaa tggagctata     4440

ggaggtgacc ttttgctcaa ttttcctgac atgtcggtcc tagagcgcca aagggctcac     4500

ctcaagtacc tcaatcccac ctttgattct cctctcgccg gcttctttgc cgattcttca     4560

atgattaccg gcggcgagat ggacagctat ctttcgactg ccggtttgaa tcttccgatg     4620

atgtacggtg agacgacggt ggaaggtgat tcaagactct caatttcgcc ggaaacgacg     4680

cttgggactg gaaatttcaa gaaacggaag tttgatacag agactaagga ttgtaatgag     4740

aagaagaaga agatgacgat gaacagagat gacctagtag aagaaggaga agaagagaag     4800

tcgaaaataa cagagcaaaa caatgggagc acaaaaagca tcaagaagat gaaacacaaa     4860

gccaagaaag aagagaacaa tttctctaat gattcatcta aagtgacgaa ggaattggag     4920

aaaacggatt atattcatgg tggcggtggc tctggaggtg gtgggtccgg aggaggcggc     4980

cgccgaccaa gtgacagcaa tgctgtttca ctggttatgc ggcggatccg aaaagaaaac     5040

gttgatgccg gtgaacgtgc aaaacaggct ctagcgttcg aacgcactga tttcgaccag     5100

gttcgttcac tcatggaaaa tagcgatcgc tgccaggata tacgtaatct ggcatttctg     5160

gggattgctt ataacaccct gttacgtata gccgaaattg ccaggatcag ggttaaagat     5220

atctcacgta ctgacggtgg gagaatgtta atccatattg gcagaacgaa aacgctggtt     5280

agcaccgcag gtgtagagaa ggcacttagc ctgggggtaa ctaaactggt cgagcgatgg     5340

atttccgtct ctggtgtagc tgatgatccg aataactacc tgttttgccg ggtcagaaaa     5400

aatggtgttg ccgcgccatc tgccaccagc cagctatcaa ctcgcgccct ggaagggatt     5460

tttgaagcaa ctcatcgatt gatttacggc gctaaggatg actctggtca gagatacctg     5520

gcctggtctg gacacagtgc ccgtgtcgga gccgcgcgag atatggcccg cgctggagtt     5580

tcaataccgg agatcatgca agctggtggc tggaccaatg taaatattgt catgaactat     5640

atccgtaacc tggatagtga aacaggggca atggtgcgcc tgctggaaga tggcgattag     5700

cccgggtagg cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat     5760

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     5820

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     5880

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     5940

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     6000

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     6060

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     6120

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     6180

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc     6240

cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaaccatg     6300

cctaaaaaga agcgtaaagt catgaagatg aagatggaca aaaagactat agtttggttt     6360

agaagagacc taaggattga ggataatcct gcattagcag cagctgctca cgaaggatct     6420

gtttttcctg tcttcatttg gtgtcctgaa gaagaaggac agttttatcc tggaagagct     6480

tcaagatggt ggatgaaaca atcacttgct cacttatctc aatccttgaa ggctcttgga     6540

tctgacctca ctttaatcaa aacccacaac acgatttcag cgatcttgga ttgtatccgc     6600

gttaccggtg ctacaaaagt cgtctttaac cacctctatg atcctgtttc gttagttcgg     6660

gaccataccg taaaggagaa gctggtggaa cgtgggatct ctgtgcaaag ctacaatgga     6720

gatctattgt atgaaccgtg ggagatatac tgcgaaaagg gcaaaccttt tacgagtttc     6780

aattcttact ggaagaaatg cttagatatg tcgattgaat ccgttatgct tcctcctcct     6840

tggcggttga tgccaataac tgcagcggct gaagcgattt gggcgtgttc gattgaagaa     6900

ctagggctgg agaatgaggc cgagaaaccg agcaatgcgt tgttaactag agcttggtct     6960

ccaggatgga gcaatgctga taagttacta aatgagttca tcgagaagca gttgatagat     7020

tatgcaaaga acagcaagaa agttgttggg aattctactt cactactttc tccgtatctc     7080

catttcgggg aaataagcgt cagacacgtt ttccagtgtg cccggatgaa acaaattata     7140

tgggcaagag ataagaacag tgaaggagaa gaaagtgcag atctttttct taggggaatc     7200

ggtttaagag agtattctcg gtatatatgt ttcaacttcc cgtttactca cgagcaatcg     7260

ttgttgagtc atcttcggtt tttcccttgg gatgctgatg ttgataagtt caaggcctgg     7320

agacaaggca ggaccggtta tccgttggtg gatgccggaa tgagagagtt ttgggctacc     7380

ggatggatgc ataacagaat aagagtgatt gtttcaagct ttgctgtgaa gtttcttctc     7440

cttccatgga aatggggaat gaagtatttc tgggatacac ttttggatgc tgatttggaa     7500

tgtgacatcc ttggctggca gtatatctct gggagtatcc ccgatggcca cgagcttgat     7560

cgcttggaca atcccgcgtt acaaggcgcc aaatatgacc cagaaggtga gtacataagg     7620

caatggcttc ccgagcttgc gagattgcca actgaatgga tccatcatcc atgggacgct     7680

cctttaaccg tactcaaagc ttctggtgtg gaactcggaa caaactatgc gaaacccatt     7740

gtagacatcg acacagctcg tgagctacta gctaaagcta tttcaagaac ccgtgaagca     7800

cagatcatga tcggagcagc acctgatgag attgtagcag atagcttcga ggccttaggg     7860

gctaatacca ttaaagaacc tggtctttgc ccatctgtgt cttctaatga ccaacaagta     7920

ccttcggctg ttggtggcgg tggctctgga ggtggtgggt ccggaggagg cggccgcacg     7980

agtgatgagg ttcgcaagaa cctgatggac atgttcaggg atcgccaggc gttttctgag     8040

catacctgga aaatgcttct gtccgtttgc cggtcgtggg cggcatggtg caagttgaat     8100

aaccggaaat ggtttcccgc agaacctgaa gatgttcgcg attatcttct atatcttcag     8160

gcgcgcggtc tggcagtaaa aactatccag caacatttgg gccagctaaa catgcttcat     8220

cgtcggtccg ggctgtaatt aattaactcc tcaggtgcag gctgcctatc agaaggtggt     8280

ggctggtgtg gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa     8340

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     8400

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg     8460

gagggcaaat catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc     8520

ccatatgctg gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca     8580

gccccctgct gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt     8640

tatattttgt tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt     8700

actagccaga tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt     8760

atggagatca taacttcgta taatgtatgc tatacgaagt tatacgcgtg ccaccatggt     8820

gagcaagggc gaggaggata acatggccat catcaaggag ttcatgcgct tcaaggtgca     8880

catggagggc tccgtgaacg gccacgagtt cgagatcgag ggcgagggcg agggccgccc     8940

ctacgagggc acccagaccg ccaagctgaa ggtgaccaag ggtggccccc tgcccttcgc     9000

ctgggacatc ctgtcccctc agttcatgta cggctccaag gcctacgtga agcaccccgc     9060

cgacatcccc gactacttga agctgtcctt ccccgagggc ttcaagtggg agcgcgtgat     9120

gaacttcgag gacggcggcg tggtgaccgt gacccaggac tcctccctgc aggacggcga     9180

gttcatctac aaggtgaagc tgcgcggcac caacttcccc tccgacggcc ccgtaatgca     9240

gaagaagacc atgggctggg aggcctcctc cgagcggatg taccccgagg acggcgccct     9300

gaagggcgag atcaagcaga ggctgaagct gaaggacggc ggccactacg acgctgaggt     9360

caagaccacc tacaaggcca agaagcccgt gcagctgccc ggcgcctaca acgtcaacat     9420

caagttggac atcacctccc acaacgagga ctacaccatc gtggaacagt acgaacgcgc     9480

cgagggccgc cactccaccg gcggcatgga cgagctgtac aagtgtggcg gctagacgcg     9540

tactcctcag gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc     9600

tcacaaatac cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     9660

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     9720

gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca     9780

gaatgagtat ttggtttaga gtttggcaac atatgcccat atgctggctg ccatgaacaa     9840

aggttggcta taaagaggtc atcagtatat gaaacagccc cctgctgtcc attccttatt     9900

ccatagaaaa gccttgactt gaggttagat tttttttata ttttgttttg tgttattttt     9960

ttctttaaca tccctaaaat tttccttaca tgttttacta gccagatttt tcctcctctc    10020

ctgactactc ccagtcatag ctgtccctct tctcttatgg agatcgccgt ttccacattc    10080

ttttctcatc cttcttctcc tgttttctct gcatcaaggt cagcacgata gcactgtctc    10140

tctatgctta gggagaggcc tgtcctgtac atcccgtgcc cccacaagat gcctactaca    10200

acaacatctt ctgcatgtcc tgcatagcag tgttgggaga atgtgcacta cttccactct    10260

tctgatttct attttatgtg tttgctttat accagtgttg ccatttggga attaatacat    10320

ggttgatcaa atcaattgca tcacagctgt atcctgtatc agaggaacat tatcaaagct    10380

tttgttgctg tatttggtat ctgacctgca gataaacatg ttttaggaag gttttgcaaa    10440

agtagctgtg aaatgagctg gtgttgtgat ttaacctgac aggcagctaa acagtatacc    10500

acagagctat tcacctactt tccctcagtg ggaaaaggga agagaactga gggggggggg    10560

aataaataag taaataacaa aataaaactc atggattaag aaaaagactt tgtactggaa    10620

tggatgagaa gaataatagt aatgataata atatgtcact ctgaaagtaa tgcctcttat    10680

ttctgtggag actacaaaca tacaaagagc acaacattcc atagagcaaa ttctcagtta    10740

cagaatgcta tttttttttt caacacagtc aaaatcatta attttttttt gcctgcaatg    10800

gacaagagct ttgaagctgt tctcgtaaaa atctgtacta gcagaagtga cctgcaatca    10860

ctactgctga aatgcacaac ccaccacatc attgtgctca cattcactgt ttggtttctg    10920

taaatgtaca ggaattgtct gaaattagat atgatttttt ttttctccat gaaggaattc    10980

aattacacac ctttgcctca tgcacttctt tgtcattttt gtcagactgc ttctctcctg    11040

caatttgtct catggcaaca aaatataatg gagttctgct gggaacttcc ctactgccat    11100

accactatca tctgcctctg acattttgga caaatgtaat aaaataggag gtattacttt    11160

cagagcagac cttgtatgta tttacaaaac aagtggtaca caaaaaaaat tgttcatccc    11220

accaaccaat gcccatcctg tccctgaata gtagctgtcc cccacagcct tgaccagttt    11280

aggtcaacag ttctgcttct gtcccctccc agctccttgt aacccctcag ccccccttgc    11340

tggcaggaca gtatgagaag ctgaaaaact agaatgtcct agttctttgc agtgctgcta    11400

atcaacaacc aaaacagtgg tgtgttacca atattgttga tatcacagca tcataccatt    11460

atgaaggaag taacccagcc aaaatcaggt cagcttgcta acaagagaac tgtgcataag    11520

tttaagatgt gtgtgttcct cagtacctta aaaaataagt agtaacgttc aaatgagtag    11580

aagagtagaa ctgagcttaa aacatctgtc agacaacagt gaaccaacc                11629


<210>  128
<211>  5894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pCAGG-Cre

<400>  128
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggttattgt gctgtctcat cattttggca aagaattcgg cttgatcgaa gcttgcccac     1740

catggcaccc aagaagaaga ggaaggtgtc caatttactg accgtacacc aaaatttgcc     1800

tgcattaccg gtcgatgcaa cgagtgatga ggttcgcaag aacctgatgg acatgttcag     1860

ggatcgccag gcgttttctg agcatacctg gaaaatgctt ctgtccgttt gccggtcgtg     1920

ggcggcatgg tgcaagttga ataaccggaa atggtttccc gcagaacctg aagatgttcg     1980

cgattatctt ctatatcttc aggcgcgcgg tctggcagta aaaactatcc agcaacattt     2040

gggccagcta aacatgcttc atcgtcggtc cgggctgcca cgaccaagtg acagcaatgc     2100

tgtttcactg gttgtgcggc ggatccgaaa agaaaacgtt gatgccggtg aacgtgcaaa     2160

acaggctcta gcgttcgaac gcactgattt cgaccaggtt cgttcactca tggaaaatag     2220

cgatcgctgc caggatatac gtaatctggc atttctgggg attgcttata acaccctgtt     2280

acgtatagcc gaaattgcca ggatcagggt taaagatatc tcacgtactg acggtgggag     2340

aatgttaatc catattggca gaacgaaaac gctggttagc accgcaggtg tagagaaggc     2400

acttagcctg ggggtaacta aactggtcga gcgatggatt tccgtctctg gtgtagctga     2460

tgatccgaat aactacctgt tttgccgggt cagaaaaaat ggtgttgccg cgccatctgc     2520

caccagccag ctatcaactc gcgccctgga agggattttt gaagcaactc atcgattgat     2580

ttacggcgct aaggatgact ctggtcagag atacctggcc tggtctggac acagtgcccg     2640

tgtcggagcc gcgcgagata tggcccgcgc tggagtttca ataccggaga tcatgcaagc     2700

tggtggctgg accaatgtaa atattgtcat gaactatatc cgtaacctgg atagtgaaac     2760

aggggcaatg gtgcgcctgc tgcaagatgg cgattagaag ctttcgatca agccgaattc     2820

actcctcagg tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct     2880

cacaaatacc actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc     2940

cttgagcatc tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg     3000

aattttttgt gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag     3060

aatgagtatt tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa     3120

ggttggctat aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc     3180

catagaaaag ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt     3240

tctttaacat ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc     3300

tgactactcc cagtcatagc tgtccctctt ctcttatgga gatccctcga cctgcagccc     3360

aagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     3420

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     3480

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     3540

ccagcggatc cgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     3600

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     3660

atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc     3720

ttttttggag gcctaggctt ttgcaaaaag ctaacttgtt tattgcagct tataatggtt     3780

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     3840

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatccgc tgcattaatg     3900

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     3960

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     4020

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     4080

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     4140

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     4200

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     4260

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     4320

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     4380

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     4440

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     4500

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     4560

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     4620

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     4680

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     4740

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     4800

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     4860

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     4920

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     4980

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     5040

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     5100

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     5160

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     5220

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     5280

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     5340

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     5400

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     5460

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     5520

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     5580

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     5640

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     5700

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     5760

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     5820

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgggtc     5880

gacattgatt attg                                                       5894


<210>  129
<211>  6086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pCAGG-FlpO

<400>  129
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggttattgt gctgtctcat cattttggca aagaattggc ggccgccacc atgagccagt     1740

tcgacatcct gtgcaagacc ccccccaagg tgctggtgcg gcagttcgtg gagagattcg     1800

agaggcccag cggcgagaag atcgccagct gtgccgccga gctgacctac ctgtgctgga     1860

tgatcaccca caacggcacc gccatcaaga gggccacctt catgagctac aacaccatca     1920

tcagcaacag cctgagcttc gacatcgtga acaagagcct gcagttcaag tacaagaccc     1980

agaaggccac catcctggag gccagcctga agaagctgat ccccgcctgg gagttcacca     2040

tcatccctta caacggccag aagcaccaga gcgacatcac cgacatcgtg tccagcctgc     2100

agctgcagtt cgagagcagc gaggaggccg acaagggcaa cagccacagc aagaagatgc     2160

tgaaggccct gctgtccgag ggcgagagca tctgggagat caccgagaag atcctgaaca     2220

gcttcgagta caccagcagg ttcaccaaga ccaagaccct gtaccagttc ctgttcctgg     2280

ccacattcat caactgcggc aggttcagcg acatcaagaa cgtggacccc aagagcttca     2340

agctggtgca gaacaagtac ctgggcgtga tcattcagtg cctggtgacc gagaccaaga     2400

caagcgtgtc caggcacatc tactttttca gcgccagagg caggatcgac cccctggtgt     2460

acctggacga gttcctgagg aacagcgagc ccgtgctgaa gagagtgaac aggaccggca     2520

acagcagcag caacaagcag gagtaccagc tgctgaagga caacctggtg cgcagctaca     2580

acaaggccct gaagaagaac gccccctacc ccatcttcgc tatcaagaac ggccctaaga     2640

gccacatcgg caggcacctg atgaccagct ttctgagcat gaagggcctg accgagctga     2700

caaacgtggt gggcaactgg agcgacaaga gggcctccgc cgtggccagg accacctaca     2760

cccaccagat caccgccatc cccgaccact acttcgccct ggtgtccagg tactacgcct     2820

acgaccccat cagcaaggag atgatcgccc tgaaggacga gaccaacccc atcgaggagt     2880

ggcagcacat cgagcagctg aagggcagcg ccgagggcag catcagatac cccgcctgga     2940

acggcatcat cagccaggag gtgctggact acctgagcag ctacatcaac aggcggatct     3000

gatgaggaat tcactcctca ggtgcaggct gcctatcaga aggtggtggc tggtgtggcc     3060

aatgccctgg ctcacaaata ccactgagat ctttttccct ctgccaaaaa ttatggggac     3120

atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat tttcattgca     3180

atagtgtgtt ggaatttttt gtgtctctca ctcggaagga catatgggag ggcaaatcat     3240

ttaaaacatc agaatgagta tttggtttag agtttggcaa catatgccca tatgctggct     3300

gccatgaaca aaggttggct ataaagaggt catcagtata tgaaacagcc ccctgctgtc     3360

cattccttat tccatagaaa agccttgact tgaggttaga ttttttttat attttgtttt     3420

gtgttatttt tttctttaac atccctaaaa ttttccttac atgttttact agccagattt     3480

ttcctcctct cctgactact cccagtcata gctgtccctc ttctcttatg gagatccctc     3540

gacctgcagc ccaagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta     3600

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc     3660

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg     3720

aaacctgtcg tgccagcgga tccgcatctc aattagtcag caaccatagt cccgccccta     3780

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     3840

ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag     3900

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctaacttg tttattgcag     3960

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     4020

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatcc     4080

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     4140

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     4200

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     4260

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     4320

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     4380

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     4440

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     4500

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     4560

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     4620

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     4680

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     4740

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     4800

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     4860

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     4920

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     4980

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     5040

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     5100

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     5160

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     5220

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     5280

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     5340

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     5400

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     5460

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     5520

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     5580

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     5640

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     5700

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     5760

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     5820

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     5880

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     5940

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     6000

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     6060

gccacctggg tcgacattga ttattg                                          6086


<210>  130
<211>  6842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pCAGG-Noggin-IRES-GFP

<400>  130
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac      660

gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      720

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      780

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc      840

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg      900

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg      960

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1020

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1080

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1140

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1200

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1260

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1320

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1380

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1440

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1500

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1620

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1680

tggttattgt gctgtctcat cattttggca aagaattcag cacctgcaca tgggacgtcg     1740

acctgaggta attataaccc gggatggatc attcccagtg ccttgtgact atatacgccg     1800

cggcggtgct gctggggctc cggctgcagc agggctcctg ccagcactac ctgcacatcc     1860

gcccggctcc cagcgacaac ctgcccctgg tggatctaat cgagcacccg gaccctatct     1920

ttgaccccaa ggagaaggat cttaacgaga ccttgctaag gagcctcatg ggaggacact     1980

tcgaccctaa ctttatggct atgtccctgc ccgaggaccg gctcggggta gacgatctgg     2040

ccgagctgga cttgctgctg cggcagagac cctcgggagc gatgcccggc gaaatcaagg     2100

ggctggagtt ctacgacggg ctgcagccgg gcaagaagca caggctgagc aagaagctgc     2160

gcaggaagct gcagatgtgg ctctggtccc agaccttctg cccggtccta tacacgtgga     2220

acgatctcgg cagccgcttt tggccccggt acgtcaaagt gggcagctgc tacagtaaaa     2280

ggtcttgctc tgtcccagaa ggcatggtct gcaaacctgc caagtccgtg catttaacga     2340

tcctgaggtg gcggtgccag cggcggggcg ggcagcggtg cacgtggatc cccatccagt     2400

accccatcat cgcggagtgc aagtgctcct gctaggctag cctccgcccc tctccctccc     2460

ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata     2520

tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg     2580

tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt     2640

tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag     2700

cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc     2760

cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga     2820

tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg     2880

cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat     2940

gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc     3000

tttgaaaaac acgatgataa tatggccaca accatggtga gcaagggcga ggagctgttc     3060

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     3120

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc     3180

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg     3240

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     3300

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     3360

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     3420

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     3480

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     3540

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     3600

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     3660

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     3720

atcactctcg gcatggacga gctgtacaag taaagcggcc gccaattcac tcctcaggtg     3780

caggctgcct atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac     3840

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg     3900

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt     3960

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg     4020

gtttagagtt tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa     4080

agaggtcatc agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc     4140

ttgacttgag gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc     4200

ctaaaatttt ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca     4260

gtcatagctg tccctcttct cttatggaga tccctcgacc tgcagcccaa gcttggcgta     4320

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat     4380

acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt     4440

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agcggatccg     4500

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     4560

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     4620

gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     4680

ctaggctttt gcaaaaagct aacttgttta ttgcagctta taatggttac aaataaagca     4740

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     4800

ccaaactcat caatgtatct tatcatgtct ggatccgctg cattaatgaa tcggccaacg     4860

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4920

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4980

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5040

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5100

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5160

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5220

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5280

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5340

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5400

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5460

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5520

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5580

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5640

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5700

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5760

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5820

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5880

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     5940

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6000

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6060

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6120

tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg     6180

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6240

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6300

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6360

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6420

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac     6480

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6540

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6600

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6660

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag     6720

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     6780

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgggtcga cattgattat     6840

tg                                                                    6842


<210>  131
<211>  7999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TV-FlpO-IRES-GFP

<400>  131
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcactag     1500

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt     1560

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac     1620

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg     1680

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag     1740

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat     1800

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat     1860

ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc     1920

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg     1980

ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg     2040

tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg     2100

gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg gggagtcgct gcgacgctgc     2160

cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc     2220

gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc     2280

ttggtttaat gacggcttgt ttcttttctg tggctgcgtg aaagccttga ggggctccgg     2340

gagggccctt tgtgcggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     2400

agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg     2460

ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc     2520

ggggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca     2580

gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc acccccctcc ccgagttgct     2640

gagcacggcc cggcttcggg tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg     2700

ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg     2760

gagggctcgg gggaggggcg cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg     2820

agccgcagcc attgcctttt atggtaatcg tgcgagaggg cgcagggact tcctttgtcc     2880

caaatctgtg cggagccgaa atctgggagg cgccgccgca ccccctctag cgggcgcggg     2940

gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg agggccttcg tgcgtcgccg     3000

cgccgccgtc cccttctccc tctccagcct cggggctgtc cgcgggggga cggctgcctt     3060

cgggggggac ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc     3120

tctgctaacc atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt     3180

attgtgctgt ctcatcattt tggcaaagaa ttcagcacct gcacatggga cgtcgacctg     3240

aggtaattat aacccggggc caccatggct cctaagaaga agaggaaggt gatgagccag     3300

ttcgacatcc tgtgcaagac cccccccaag gtgctggtgc ggcagttcgt ggagagattc     3360

gagaggccca gcggcgagaa gatcgccagc tgtgccgccg agctgaccta cctgtgctgg     3420

atgatcaccc acaacggcac cgccatcaag agggccacct tcatgagcta caacaccatc     3480

atcagcaaca gcctgagctt cgacatcgtg aacaagagcc tgcagttcaa gtacaagacc     3540

cagaaggcca ccatcctgga ggccagcctg aagaagctga tccccgcctg ggagttcacc     3600

atcatccctt acaacggcca gaagcaccag agcgacatca ccgacatcgt gtccagcctg     3660

cagctgcagt tcgagagcag cgaggaggcc gacaagggca acagccacag caagaagatg     3720

ctgaaggccc tgctgtccga gggcgagagc atctgggaga tcaccgagaa gatcctgaac     3780

agcttcgagt acaccagcag gttcaccaag accaagaccc tgtaccagtt cctgttcctg     3840

gccacattca tcaactgcgg caggttcagc gacatcaaga acgtggaccc caagagcttc     3900

aagctggtgc agaacaagta cctgggcgtg atcattcagt gcctggtgac cgagaccaag     3960

acaagcgtgt ccaggcacat ctactttttc agcgccagag gcaggatcga ccccctggtg     4020

tacctggacg agttcctgag gaacagcgag cccgtgctga agagagtgaa caggaccggc     4080

aacagcagca gcaacaagca ggagtaccag ctgctgaagg acaacctggt gcgcagctac     4140

aacaaggccc tgaagaagaa cgccccctac cccatcttcg ctatcaagaa cggccctaag     4200

agccacatcg gcaggcacct gatgaccagc tttctgagca tgaagggcct gaccgagctg     4260

acaaacgtgg tgggcaactg gagcgacaag agggcctccg ccgtggccag gaccacctac     4320

acccaccaga tcaccgccat ccccgaccac tacttcgccc tggtgtccag gtactacgcc     4380

tacgacccca tcagcaagga gatgatcgcc ctgaaggacg agaccaaccc catcgaggag     4440

tggcagcaca tcgagcagct gaagggcagc gccgagggca gcatcagata ccccgcctgg     4500

aacggcatca tcagccagga ggtgctggac tacctgagca gctacatcaa caggcggatc     4560

tgagctagcc gatccgcccc tctccctccc ccccccctaa cgttactggc cgaagccgct     4620

tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg     4680

gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt     4740

cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg     4800

aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac     4860

ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg     4920

cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct     4980

caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg     5040

atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag     5100

gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca     5160

accatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg     5220

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc     5280

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc     5340

accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg     5400

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc     5460

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc     5520

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg     5580

cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag     5640

aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc     5700

gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac     5760

cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg     5820

gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag     5880

taaagcggcc gccaattcac tcctcaggtg caggctgcct atcagaaggt ggtggctggt     5940

gtggccaatg ccctggctca caaataccac tgagatcttt ttccctctgc caaaaattat     6000

ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc     6060

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaaggacata tgggagggca     6120

aatcatttaa aacatcagaa tgagtatttg gtttagagtt tggcaacata tgcccatatg     6180

ctggctgcca tgaacaaagg ttggctataa agaggtcatc agtatatgaa acagccccct     6240

gctgtccatt ccttattcca tagaaaagcc ttgacttgag gttagatttt ttttatattt     6300

tgttttgtgt tatttttttc tttaacatcc ctaaaatttt ccttacatgt tttactagcc     6360

agatttttcc tcctctcctg actactccca gtcatagctg tccctcttct cttatggaga     6420

tccctcgacc tgcatgccgt ttccacattc ttttctcatc cttcttctcc tgttttctct     6480

gcatcaaggt cagcacgata gcactgtctc tctatgctta gggagaggcc tgtcctgtac     6540

atcccgtgcc cccacaagat gcctactaca acaacatctt ctgcatgtcc tgcatagcag     6600

tgttgggaga atgtgcacta cttccactct tctgatttct attttatgtg tttgctttat     6660

accagtgttg ccatttggga attaatacat ggttgatcaa atcaattgca tcacagctgt     6720

atcctgtatc agaggaacat tatcaaagct tttgttgctg tatttggtat ctgacctgca     6780

gataaacatg ttttaggaag gttttgcaaa agtagctgtg aaatgagctg gtgttgtgat     6840

ttaacctgac aggcagctaa acagtatacc acagagctat tcacctactt tccctcagtg     6900

ggaaaaggga agagaactga gggggggggg aataaataag taaataacaa aataaaactc     6960

atggattaag aaaaagactt tgtactggaa tggatgagaa gaataatagt aatgataata     7020

atatgtcact ctgaaagtaa tgcctcttat ttctgtggag actacaaaca tacaaagagc     7080

acaacattcc atagagcaaa ttctcagtta cagaatgcta tttttttttt caacacagtc     7140

aaaatcatta attttttttt gcctgcaatg gacaagagct ttgaagctgt tctcgtaaaa     7200

atctgtacta gcagaagtga cctgcaatca ctactgctga aatgcacaac ccaccacatc     7260

attgtgctca cattcactgt ttggtttctg taaatgtaca ggaattgtct gaaattagat     7320

atgatttttt ttttctccat gaaggaattc aattacacac ctttgcctca tgcacttctt     7380

tgtcattttt gtcagactgc ttctctcctg caatttgtct catggcaaca aaatataatg     7440

gagttctgct gggaacttcc ctactgccat accactatca tctgcctctg acattttgga     7500

caaatgtaat aaaataggag gtattacttt cagagcagac cttgtatgta tttacaaaac     7560

aagtggtaca caaaaaaaat tgttcatccc accaaccaat gcccatcctg tccctgaata     7620

gtagctgtcc cccacagcct tgaccagttt aggtcaacag ttctgcttct gtcccctccc     7680

agctccttgt aacccctcag ccccccttgc tggcaggaca gtatgagaag ctgaaaaact     7740

agaatgtcct agttctttgc agtgctgcta atcaacaacc aaaacagtgg tgtgttacca     7800

atattgttga tatcacagca tcataccatt atgaaggaag taacccagcc aaaatcaggt     7860

cagcttgcta acaagagaac tgtgcataag tttaagatgt gtgtgttcct cagtacctta     7920

aaaaataagt agtaacgttc aaatgagtag aagagtagaa ctgagcttaa aacatctgtc     7980

agacaacagt gaaccaacc                                                  7999


<210>  132
<211>  7263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TV-Cre-P2A-GFP

<400>  132
gaatgaaggg cctgagggtg ggcagtctgt ctatcatgta catctccata ttctgggagg       60

tcgtcagttg ggctggcctc ctggctaaga tttttgcacc acaagagatg ctgcatgtgt      120

acaaatcact agcaaataga tttgtttccc atcaacttag ccactgttaa tgtaaattgt      180

tcttggatat gtgtctttgg agggcaataa atgctctgaa cagcacttgc acaataaaga      240

tacagcatgt gggaatgatc tgtctcatgt gtcttactga tggtattggt tctgtaagat      300

aaaatattgt gtctgggatg tgtttggctc tactattaat ggtgctctat tgattgtgat      360

ttgtcatttg aaacctgagg atgcgactgt atagcagtct ttcatgcatt tttggaaaaa      420

aacttaagct ttttgaaagc tgctgctaca actttttgta ttgttataaa gttttgtatt      480

gtttttttaa ttgtgaaatt ataaagatgc cgtgcaggga ctgtttgaag caaagtgcat      540

tgttttagaa acctacaact ctagttcaag cactccatca gtatctgctt aatctttgtc      600

atcctttgct atgagaaaat attaagcagt agtctaaagg tactatgaaa ctataacata      660

gctgacattg tatttataac tacgtcatga ttttgataga attgaggact tgaaaatgtt      720

aaactattca tgtagggcct cttaagatgc ttaagttgtt tagtaatgta agtgtgcatt      780

taattgagat tttattgggc ataatttgtc catcagtatg acactccttg tcagtgttgc      840

cttatacttg atgttgttac cggatctctg caaggcagtt attcttgaat taggctcatt      900

gaagtgtctg ccagtataaa tatatagcaa ctgttctttg tgttaaaatt gagaagctaa      960

ccagttttta gtgcttctga ctgttggaat tctttaagca gatgccataa gaaaattgta     1020

tttgtgatca ccacttctcc agagtggttt taacaccaag ggcattagag aaagaaaggc     1080

aggcgtgtag agaatagtgg acagacaaaa gctgtgagtt acgttatgtt tttcagctga     1140

aaagctgtgt ttggtaaaag catatgaaat cactcaactt ggaagcattc tcttagttct     1200

ctgatagttc tgagcagcag aactcttcac ctaagaggtt acttcaactg gaagactacc     1260

tagtgcttct gatggcaact atatttaaga tgagaataag aggtgtttcc agtgtggtag     1320

cctcacatct gttgcagtgg ttaccgttcg tcctcctccg agggacacag cttggccatt     1380

cactgtggtg acaccaatat gatgatcagc aaatggtgtt tattcactac taaacacagc     1440

ttatatacat ttttacctac aaaatcgtgc tgtcatgtcc cactctgatt ggttcattaa     1500

ttaagaagtt cctattccga agttcctatt ctctagaaag tataggaact tcgtcgacat     1560

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat     1620

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac     1680

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc     1740

cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg     1800

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat     1860

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc     1920

atcgctatta ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc     1980

ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg     2040

gcgggggggg ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg     2100

gcgaggcgga gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt     2160

atggcgaggc ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcggggagt     2220

cgctgcgacg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc     2280

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg     2340

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     2400

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     2460

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     2520

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     2580

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     2640

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     2700

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     2760

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     2820

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     2880

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     2940

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     3000

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     3060

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     3120

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     3180

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     3240

gcaacgtgct ggttaggtac catggcaccc aagaagaaga ggaaggtgtc caatttactg     3300

accgtacacc aaaatttgcc tgcattaccg gtcgatgcaa cgagtgatga ggttcgcaag     3360

aacctgatgg acatgttcag ggatcgccag gcgttttctg agcatacctg gaaaatgctt     3420

ctgtccgttt gccggtcgtg ggcggcatgg tgcaagttga ataaccggaa atggtttccc     3480

gcagaacctg aagatgttcg cgattatctt ctatatcttc aggcgcgcgg tctggcagta     3540

aaaactatcc agcaacattt gggccagcta aacatgcttc atcgtcggtc cgggctgcca     3600

cgaccaagtg acagcaatgc tgtttcactg gttgtgcggc ggatccgaaa agaaaacgtt     3660

gatgccggtg aacgtgcaaa acaggctcta gcgttcgaac gcactgattt cgaccaggtt     3720

cgttcactca tggaaaatag cgatcgctgc caggatatac gtaatctggc atttctgggg     3780

attgcttata acaccctgtt acgtatagcc gaaattgcca ggatcagggt taaagatatc     3840

tcacgtactg acggtgggag aatgttaatc catattggca gaacgaaaac gctggttagc     3900

accgcaggtg tagagaaggc acttagcctg ggggtaacta aactggtcga gcgatggatt     3960

tccgtctctg gtgtagctga tgatccgaat aactacctgt tttgccgggt cagaaaaaat     4020

ggtgttgccg cgccatctgc caccagccag ctatcaactc gcgccctgga agggattttt     4080

gaagcaactc atcgattgat ttacggcgct aaggatgact ctggtcagag atacctggcc     4140

tggtctggac acagtgcccg tgtcggagcc gcgcgagata tggcccgcgc tggagtttca     4200

ataccggaga tcatgcaagc tggtggctgg accaatgtaa atattgtcat gaactatatc     4260

cgtaacctgg atagtgaaac aggggcaatg gtgcgcctgc tgcaagatgg cgatcccggg     4320

ggaagcggag ctactaactt cagcctgctg aagcaggctg gcgacgtgga ggagaaccct     4380

ggacctatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag     4440

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc     4500

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg     4560

cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac     4620

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc     4680

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac     4740

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg     4800

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag     4860

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag     4920

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac     4980

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac     5040

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac     5100

aagtaaagcg gccgccaatt cactcctcag gtgcaggctg cctatcagaa ggtggtggct     5160

ggtgtggcca atgccctggc tcacaaatac cactgagatc tttttccctc tgccaaaaat     5220

tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt     5280

ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg     5340

gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat     5400

atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc     5460

cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata     5520

ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta     5580

gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg     5640

agatcgaagt tcctattccg aagttcctat tctctagaaa gtataggaac ttcgctagcg     5700

ccgtttccac attcttttct catccttctt ctcctgtttt ctctgcatca aggtcagcac     5760

gatagcactg tctctctatg cttagggaga ggcctgtcct gtacatcccg tgcccccaca     5820

agatgcctac tacaacaaca tcttctgcat gtcctgcata gcagtgttgg gagaatgtgc     5880

actacttcca ctcttctgat ttctatttta tgtgtttgct ttataccagt gttgccattt     5940

gggaattaat acatggttga tcaaatcaat tgcatcacag ctgtatcctg tatcagagga     6000

acattatcaa agcttttgtt gctgtatttg gtatctgacc tgcagataaa catgttttag     6060

gaaggttttg caaaagtagc tgtgaaatga gctggtgttg tgatttaacc tgacaggcag     6120

ctaaacagta taccacagag ctattcacct actttccctc agtgggaaaa gggaagagaa     6180

ctgagggggg ggggaataaa taagtaaata acaaaataaa actcatggat taagaaaaag     6240

actttgtact ggaatggatg agaagaataa tagtaatgat aataatatgt cactctgaaa     6300

gtaatgcctc ttatttctgt ggagactaca aacatacaaa gagcacaaca ttccatagag     6360

caaattctca gttacagaat gctatttttt ttttcaacac agtcaaaatc attaattttt     6420

ttttgcctgc aatggacaag agctttgaag ctgttctcgt aaaaatctgt actagcagaa     6480

gtgacctgca atcactactg ctgaaatgca caacccacca catcattgtg ctcacattca     6540

ctgtttggtt tctgtaaatg tacaggaatt gtctgaaatt agatatgatt ttttttttct     6600

ccatgaagga attcaattac acacctttgc ctcatgcact tctttgtcat ttttgtcaga     6660

ctgcttctct cctgcaattt gtctcatggc aacaaaatat aatggagttc tgctgggaac     6720

ttccctactg ccataccact atcatctgcc tctgacattt tggacaaatg taataaaata     6780

ggaggtatta ctttcagagc agaccttgta tgtatttaca aaacaagtgg tacacaaaaa     6840

aaattgttca tcccaccaac caatgcccat cctgtccctg aatagtagct gtcccccaca     6900

gccttgacca gtttaggtca acagttctgc ttctgtcccc tcccagctcc ttgtaacccc     6960

tcagcccccc ttgctggcag gacagtatga gaagctgaaa aactagaatg tcctagttct     7020

ttgcagtgct gctaatcaac aaccaaaaca gtggtgtgtt accaatattg ttgatatcac     7080

agcatcatac cattatgaag gaagtaaccc agccaaaatc aggtcagctt gctaacaaga     7140

gaactgtgca taagtttaag atgtgtgtgt tcctcagtac cttaaaaaat aagtagtaac     7200

gttcaaatga gtagaagagt agaactgagc ttaaaacatc tgtcagacaa cagtgaacca     7260

acc                                                                   7263


