                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
       Bordey, Angelique
       Hsieh, Lawrence
       Zhou, Jianbing
 
<120>  Methods of Treating and Diagnosing Epilepsy

<130>  047162-7219WO1(01094)

<150>  US 62/813,429
<151>  2019-03-04

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Gly 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Val Ala Ala Gly Cys 
    50                  55                  60                  


Ser Glu Ser Arg Gly Ala Ala Leu Gly Ala Thr Glu Ser Glu Gly Pro 
65                  70                  75                  80  


Gly Arg Ser Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Ala Gly Gly Gly Ser Ser Leu Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg 
    130                 135                 140                 


Thr Pro Pro Gly Leu Ala Thr Glu Pro Glu Arg Pro Ala Thr Ala Ala 
145                 150                 155                 160 


Gln Pro Ala Ala Ser Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Ala Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Ile Asp His Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ser Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Val Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Glu Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Val Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro His Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Gly Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Arg Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Lys Lys Asn Ser 
    690                 695                 700                 


Ile Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn 
705                 710                 715                 720 


Tyr Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Arg His Asp Arg Glu 
                725                 730                 735     


Met Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro 
            740                 745                 750         


Thr Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln 
        755                 760                 765             


Ala Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro 
    770                 775                 780                 


Arg Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Pro Gly Leu Gly 
785                 790                 795                 800 


Asn Leu Gly Ala Gly Gln Thr Pro Arg His Pro Arg Arg Leu Gln Ser 
                805                 810                 815     


Leu Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser 
            820                 825                 830         


Gln Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala 
        835                 840                 845             


Gly Phe Ser Ala Pro Pro Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser 
    850                 855                 860                 


Ser Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Pro Ala Pro Thr Pro 
865                 870                 875                 880 


Ser Thr Ser Thr Ala Ala Ala Ala Ser Thr Thr Gly Phe Gly His Phe 
                885                 890                 895     


His Lys Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu 
            900                 905                 910         


Thr Pro Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Pro 
        915                 920                 925             


Pro Pro Leu Pro Gly Ala Arg Gly Gly Leu Gly Leu Leu Glu His Phe 
    930                 935                 940                 


Leu Pro Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln 
945                 950                 955                 960 


Leu Gly Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Ala Gly Pro 
                965                 970                 975     


Ser Ser Thr Pro Glu Thr Pro Pro Arg Pro Glu Arg Pro Ser Phe Met 
            980                 985                 990         


Ala Gly Ala Ser Gly Gly Ala Ser  Pro Val Ala Phe Thr  Pro Arg Gly 
        995                 1000                 1005             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1010                 1015                 1020             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1025                 1030                 1035             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1040                 1045                 1050             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1055                 1060                 1065             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1070                 1075                 1080             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Val 
    1085                 1090                 1095             


Ala Ala  Phe Ser Leu Tyr Pro  Arg Ala Gly Gly Gly  Ser Gly Ser 
    1100                 1105                 1110             


Ser Gly  Gly Leu Gly Pro Pro  Gly Arg Pro Tyr Gly  Ala Ile Pro 
    1115                 1120                 1125             


Gly Gln  His Val Thr Leu Pro  Arg Lys Thr Ser Ser  Gly Ser Leu 
    1130                 1135                 1140             


Pro Pro  Pro Leu Ser Leu Phe  Gly Ala Arg Ala Ala  Ser Ser Gly 
    1145                 1150                 1155             


Gly Pro  Pro Leu Thr Thr Ala  Ala Pro Gln Arg Glu  Pro Gly Ala 
    1160                 1165                 1170             


Arg Ser  Glu Pro Val Arg Ser  Lys Leu Pro Ser Asn  Leu 
    1175                 1180                 1185     


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  2
caaattctcc ctccgcatgt t                                                 21


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  3
tgaagaacgt gattccaact gg                                                22


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
ccggcgtcaa caagttctc                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
tgcccacggg aatgataatg a                                                 21


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
ggcggacacc gctatcaaa                                                    19


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
tgccgaacat ccttagggag a                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
agccgagctc atggacgggt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
ctgtcgtggg tgcagcctgg                                                   20


<210>  10
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
accaccatgg agaaggc                                                      17


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
ggcatggact gtggtcatga                                                   20


