                         SEQUENCE LISTING

<110>  Cue Biopharma, Inc.
 
<120>  ANTIGEN-PRESENTING POLYPEPTIDES WITH CHEMICAL CONJUGATION SITES 
       AND METHODS OF USE THEREOF

<130>  123640-8007.WO00

<150>  US 62/814,850
<151>  2019-03-06

<160>  283

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  2
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  3
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  3

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  4
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  5
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Thr Ser Thr Leu Thr Ile Lys Glx Ser Asp Trp Leu Gly Glu Ser 
1               5                   10                  15      


Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn 
            20                  25                  30          


Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe 
        35                  40                  45              


Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys 
    50                  55                  60                  


Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asx Ser Val Thr Ile 
65                  70                  75                  80  


Ser Trp Thr Arg Glu Glu Asn Gly Ala Val Lys Thr His Thr Asn Ile 
                85                  90                  95      


Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser 
            100                 105                 110         


Ile Cys Glu Asp Asx Asp Trp Ser Gly Glu Arg Phe Thr Cys Thr Val 
        115                 120                 125             


Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro 
    130                 135                 140                 


Lys Gly Val Ala Leu His Arg Pro Asx Val Tyr Leu Leu Pro Pro Ala 
145                 150                 155                 160 


Arg Glx Glx Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val 
                165                 170                 175     


Thr Gly Phe Ser Pro Ala Asp Val Phe Val Glu Trp Met Gln Arg Gly 
            180                 185                 190         


Glu Pro Leu Ser Pro Gln Lys Tyr Val Thr Ser Ala Pro Met Pro Glu 
        195                 200                 205             


Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser 
    210                 215                 220                 


Glu Glu Glu Trp Asn Thr Gly Gly Thr Tyr Thr Cys Val Val Ala His 
225                 230                 235                 240 


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
                245                 250                 255     


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
            260                 265                 270         


Gly Thr Cys Tyr 
        275     


<210>  6
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  7
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  8
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  9
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  10
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  11
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  12
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  13
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  14
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile 
    210                 215                 


<210>  15
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  16
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  17
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  18
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  19
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  20
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  21
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
            100                 105                 110 


<210>  22
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  23
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  24
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  25
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  26
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  27
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  28
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  29
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
1               5                   10                  15      


Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
            20                  25                  30          


Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
        35                  40                  45              


Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
    50                  55                  60                  


Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
65                  70                  75                  80  


Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
                85                  90                  95      


Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
            100                 105                 110         


Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
        115                 120                 125             


Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
    130                 135                 140                 


Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
145                 150                 155                 160 


Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
                165                 170                 175     


Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
            180                 185                 190         


Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
        195                 200                 205             


Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
    210                 215                 220                 


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
225                 230                 235                 240 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
                245                 250                 255     


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
            260                 265                 270         


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
        275                 280                 285             


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
    290                 295                 300                 


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
305                 310                 315                 320 


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
                325                 330                 335     


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
            340                 345                 350         


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
        355                 360                 365             


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
    370                 375                 380                 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
385                 390                 395                 400 


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
                405                 410                 415     


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
            420                 425                 430         


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
        435                 440                 445             


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
    450                 455                 460                 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
465                 470                 475                 480 


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
                485                 490                 495     


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 


<210>  30
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
                245                 250                 255     


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            260                 265                 270         


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        275                 280                 285             


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    290                 295                 300                 


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
305                 310                 315                 320 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                325                 330                 335     


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345         


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag hemagglutinin

<400>  31

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag FLAG

<400>  32

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag  c-myc

<400>  33

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  34
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  34

His His His His His 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  35

His His His His His His 
1               5       


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  37
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Tyr Ile Arg Ser 
1               5   


<210>  38
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe His His Thr 
1               


<210>  39
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  39

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytically cleavable linker

<400>  40

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytically cleavable linker

<400>  41

Glu Asn Leu Tyr Thr Gln Ser 
1               5           


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytically cleavable linker

<400>  42

Asp Asp Asp Asp Lys 
1               5   


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytically cleavable linker

<400>  43

Leu Val Pro Arg 
1               


<210>  44
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytically cleavable linker

<400>  44

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Can be present or absent and, when present, can be any aa, 
       usually L, M, V, S or T, more usually L, M, S or V, with the 
       proviso that, when the sulfatase motif is at the N-terminus of 
       the target polypeptide.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Noted as Z1, can be cysteine or serine.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Noted as X2, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Noted as Z2, can be either a proline or alanine residue (which 
       can also be represented by "P/A").

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Noted as X3, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Noted as Z3, can be a basic aa (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  45

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Can be C or S.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Noted as X2, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Can be P or A.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Noted as X3, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Noted as Z3, can be a basic aa (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  46

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Can be present or absent and, when present, can be any aa, 
       usually L, M, V, S or T, more usually L, M, S or V, with the 
       proviso that, when the sulfatase motif is at the N-terminus of 
       the target polypeptide.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Noted as Z1, is a cysteine.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Noted as X2, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Noted as Z2, is a proline.

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Noted as X3, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Noted as Z3, can be a basic aa (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  47

Xaa Cys Xaa Pro Xaa Xaa 
1               5       


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Noted as X2, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Noted as X3, can be any aa, usually S, T, A, V, G or C, more 
       usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Noted as Z3, can be a basic aa (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  48

Cys Xaa Pro Xaa Xaa 
1               5   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif

<400>  49

Ala Ala Leu Leu Thr Gly Arg 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif

<400>  50

Ser Gln Leu Leu Thr Gly Arg 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif

<400>  51

Ala Ala Phe Met Thr Gly Arg 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif

<400>  52

Ala Ala Phe Leu Thr Gly Arg 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif

<400>  53

Gly Ser Leu Phe Thr Gly Arg 
1               5           


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site


<220>
<221>  SITE
<222>  (3)..(3)
<223>  Noted as X5, can be any amino acid.

<220>
<221>  SITE
<222>  (5)..(5)
<223>  Can be glycine or alanine.

<400>  54

Leu Pro Xaa Thr Xaa 
1               5   


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  55

Gly Gly Gly Gly 
1               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  56

Gly Gly Gly Gly Gly 
1               5   


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  57

Ala Ala Ala Ala 
1               


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  58

Ala Ala Ala Ala Ala 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  59

Leu Pro Glu Thr Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  60

Leu Pro Glu Thr Ala 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  61

Leu Val Pro Arg Gly 
1               5   


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  62

Leu Gln Gly Leu Leu Gln Gly Gly 
1               5               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  63

Leu Leu Gln Gly 
1               


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  64

Leu Ser Leu Ser Gln Gly 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  65

Leu Leu Gln Leu Gln Gly 
1               5       


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  66

Gly Ser Gly Gly Ser 
1               5   


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  67

Gly Gly Gly Ser 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  68

Gly Gly Gly Ser 
1               


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  69

Gly Gly Ser Gly Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  70

Gly Ser Gly Ser Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  71

Gly Ser Gly Gly Gly 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  72

Gly Gly Gly Ser Gly 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  73

Gly Ser Ser Ser Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  74

Gly Ser Ser Ser Ser 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  75

Ala Ala Ala Gly Gly 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  76

Gly Gly Gly Gly Ser 
1               5   


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  77

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  78

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker or spacer

<400>  79

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  80
<211>  9
<212>  PRT
<213>  Human papillomavirus type 1a

<400>  80

Leu Leu Met Gly Thr Leu Gly Ile Val 
1               5                   


<210>  81
<211>  8
<212>  PRT
<213>  Human papillomavirus type 1a

<400>  81

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  82
<211>  10
<212>  PRT
<213>  Human papillomavirus type 1a

<400>  82

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  Human papillomavirus type 1a

<400>  83

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  84
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  84

Phe Thr Val Arg Glu Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
1               5                   10                  15      


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
            20                  25                  30          


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
        35                  40                  45              


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
    50                  55                  60                  


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
                85                  90                  95      


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
            100                 105                 110         


<210>  85
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  85

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  86
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  86

Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu 
            20                  25                  30          


Arg 
    


<210>  87
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  87

Leu Ser Ser Ile Glu Lys Lys Gln Glu Glu Gln Thr Ser Trp Leu Ile 
1               5                   10                  15      


Trp Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln Ser 
            20                  25                  30          


<210>  88
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  88

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  89
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  89

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  90
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  90

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Gln 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  91
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Ser Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Leu Arg Asn Glu Leu Thr Leu Leu Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  92
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  92

Ile Ser Ser Leu Glu Lys Lys Ile Glu Glu Leu Thr Ser Gln Ile Gln 
1               5                   10                  15      


Gln Leu Arg Asn Glu Ile Thr Leu Leu Arg Asn Glu Ile Ala Gln 
            20                  25                  30      


<210>  93
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  93

Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210>  94
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


<210>  95
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  95

Leu Lys Ser Val Glu Asn Arg Leu Ala Val Val Glu Asn Gln Leu Lys 
1               5                   10                  15      


Thr Val Ile Glu Glu Leu Lys Thr Val Lys Asp Leu Leu Ser Asn 
            20                  25                  30      


<210>  96
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Ala Arg Ile Glu Glu Lys Leu Lys Thr Ile Lys Ala Gln Leu Ser 
1               5                   10                  15      


Glu Ile Ala Ser Thr Leu Asn Met Ile Arg Glu Gln Leu Ala Gln 
            20                  25                  30      


<210>  97
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  97

Val Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ser Gln Val Thr 
1               5                   10                  15      


Glu Leu Ala Ser Thr Val Ser Leu Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30      


<210>  98
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  98

Ile Gln Ser Glu Lys Lys Ile Glu Asp Ile Ser Ser Leu Ile Gly Gln 
1               5                   10                  15      


Ile Gln Ser Glu Ile Thr Leu Ile Arg Asn Glu Ile Ala Gln 
            20                  25                  30  


<210>  99
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  99

Leu Met Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Gln Thr Leu Met 
1               5                   10                  15      


Gln Leu Gln Asn Glu Leu Ser Met Leu Lys Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  100
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  100

Val Asp Leu Glu Gly Ser Thr Ser Asn Gly Arg Gln Cys Ala Gly Ile 
1               5                   10                  15      


Arg Leu 
        


<210>  101
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Asp Asp Val Thr Thr Thr Glu Glu Leu Ala Pro Ala Leu Val Pro 
1               5                   10                  15      


Pro Pro Lys Gly Thr Cys Ala Gly Trp Met Ala 
            20                  25          


<210>  102
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  102

Gly His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro 
1               5                   10                  15      


Leu Pro Lys Gly Ala Cys Thr Gly Gln Met Ala 
            20                  25          


<210>  103
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Can be any amino acid other than proline.

<400>  103

Val Pro Gly Xaa Gly 
1               5   


<210>  104
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  104

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  105
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  105

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp 
        


<210>  106
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu 
1               5                   10                  15      


Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala 
            20                  25                  30          


Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser 
        35                  40                  45              


Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn 
    50                  55                  60                  


Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn 
65                  70                  75                  


<210>  107
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  107

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Arg Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Ala Asn Asp Pro Pro Glu Val Thr Val Phe Pro 
                85                  90                  95      


Lys Glu Pro Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile 
            100                 105                 110         


Asp Arg Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly 
        115                 120                 125             


Glu Pro Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr 
    130                 135                 140                 


Asp Tyr Ser Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala 
145                 150                 155                 160 


Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  108
<211>  260
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(260)
<223>  GenBank NP_001229453.1 and IMGT/HLA Acc No: HLA00499 MHC Class II
       DPA1(DPA1*01:03) alpha chain

<400>  108

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  109
<211>  260
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(260)
<223>  IMGT/HLA Acc No: HLA00504 MHC Class II DPA1:02(DPA1*02:01) alpha 
       chain

<400>  109

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Gln Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Arg Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Ala Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Arg Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Pro Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Val Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Pro Leu 
            260 


<210>  110
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Arg Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Ala Asn 
                85          


<210>  111
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  111

Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val Glu Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys His Ile Asp Arg Phe Phe Pro Pro Val 
            20                  25                  30          


Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Pro Val Thr Glu Gly Val 
        35                  40                  45              


Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe His Lys Phe 
    50                  55                  60                  


His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  112
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Leu Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  113
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  114
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Ala Val Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  115
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  116
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  117
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  118
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  119
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  120
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  121
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  122
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  123
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  124
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Leu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  125
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Lys Gln Asp Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu His Arg Gly Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  126
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Pro Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  127
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  128
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  129
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  130
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  131
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg His Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  132
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  133
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  134
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  134

Val Pro Glu Ala Pro Thr Pro Met Trp Pro Asp Asp Leu Gln Asn His 
1               5                   10                  15      


Thr Phe Leu His Thr Val Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly 
            20                  25                  30          


Leu Ser Glu Ala Tyr Asp Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser 
        35                  40                  45              


Gln Asn Thr Arg Val Pro Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln 
    50                  55                  60                  


Glu Gln Gly Asp Ala Pro Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu 
65                  70                  75                  80  


Trp Met Ile Gln Gln Ile Gly Pro Lys Leu Asp Gly Lys Ile Pro Val 
                85                  90                  95      


Ser Arg Gly Phe Pro Ile Ala Glu Val Phe Thr Leu Lys Pro Leu Glu 
            100                 105                 110         


Phe Gly Lys Pro Asn Thr Leu Val Cys Phe Val Ser Asn Leu Phe Pro 
        115                 120                 125             


Pro Met Leu Thr Val Asn Trp Gln His His Ser Val Pro Val Glu Gly 
    130                 135                 140                 


Phe Gly Pro Thr Phe Val Ser Ala Val Asp Gly Leu Ser Phe Gln Ala 
145                 150                 155                 160 


Phe Ser Tyr Leu Asn Phe Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys 
                165                 170                 175     


Ile Val Thr His Glu Ile Asp Arg Tyr Thr Ala Ile Ala Tyr Trp 
            180                 185                 190     


<210>  135
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  135

Val Pro Glu Ala Pro Thr Pro Met Trp Pro Asp Asp Leu Gln Asn His 
1               5                   10                  15      


Thr Phe Leu His Thr Val Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly 
            20                  25                  30          


Leu Ser Glu Ala Tyr Asp Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser 
        35                  40                  45              


Gln Asn Thr Arg Val Pro Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln 
    50                  55                  60                  


Glu Gln Gly Asp Ala Pro Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu 
65                  70                  75                  80  


Trp Met Ile Gln Gln Ile Gly Pro Lys Leu Asp Gly Lys Ile Pro Val 
                85                  90                  95      


Ser Arg 
        


<210>  136
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Phe Pro Ile Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly 
1               5                   10                  15      


Lys Pro Asn Thr Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met 
            20                  25                  30          


Leu Thr Val Asn Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly 
        35                  40                  45              


Pro Thr Phe Val Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser 
    50                  55                  60                  


Tyr Leu Asn Phe Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val 
65                  70                  75                  80  


Thr His Glu Ile Asp Arg Tyr Thr Ala Ile Ala Tyr Trp 
                85                  90              


<210>  137
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  137

Thr Lys Ala Asp His Met Gly Ser Tyr Gly Pro Ala Phe Tyr Gln Ser 
1               5                   10                  15      


Tyr Gly Ala Ser Gly Gln Phe Thr His Glu Phe Asp Glu Glu Gln Leu 
            20                  25                  30          


Phe Ser Val Asp Leu Lys Lys Ser Glu Ala Val Trp Arg Leu Pro Glu 
        35                  40                  45              


Phe Gly Asp Phe Ala Arg Phe Asp Pro Gln Gly Gly Leu Ala Gly Ile 
    50                  55                  60                  


Ala Ala Ile Lys Ala His Leu Asp Ile Leu Val Glu Arg Ser Asn Arg 
65                  70                  75                  80  


Ser Arg Ala Ile Asn Val Pro Pro Arg Val Thr Val Leu Pro Lys Ser 
                85                  90                  95      


Arg Val Glu Leu Gly Gln Pro Asn Ile Leu Ile Cys Ile Val Asp Asn 
            100                 105                 110         


Ile Phe Pro Pro Val Ile Asn Ile Thr Trp Leu Arg Asn Gly Gln Thr 
        115                 120                 125             


Val Thr Glu Gly Val Ala Gln Thr Ser Phe Tyr Ser Gln Pro Asp His 
    130                 135                 140                 


Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Val Pro Ser Ala Glu Asp 
145                 150                 155                 160 


Val Tyr Asp Cys Gln Val Glu His Trp Gly Leu Asp Ala Pro Leu Leu 
                165                 170                 175     


Arg His Trp 
            


<210>  138
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  138

Thr Lys Ala Asp His Met Gly Ser Tyr Gly Pro Ala Phe Tyr Gln Ser 
1               5                   10                  15      


Tyr Gly Ala Ser Gly Gln Phe Thr His Glu Phe Asp Glu Glu Gln Leu 
            20                  25                  30          


Phe Ser Val Asp Leu Lys Lys Ser Glu Ala Val Trp Arg Leu Pro Glu 
        35                  40                  45              


Phe Gly Asp Phe Ala Arg Phe Asp Pro Gln Gly Gly Leu Ala Gly Ile 
    50                  55                  60                  


Ala Ala Ile Lys Ala His Leu Asp Ile Leu Val Glu Arg Ser Asn Arg 
65                  70                  75                  80  


Ser Arg Ala Ile Asn 
                85  


<210>  139
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  139

Val Pro Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly 
1               5                   10                  15      


Gln Pro Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Ile Asn Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val 
        35                  40                  45              


Ala Gln Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp 
                85                  90                  


<210>  140
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro 
                85                  90                  95      


Lys Glu Pro Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile 
            100                 105                 110         


Asp Lys Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly 
        115                 120                 125             


Glu Leu Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr 
    130                 135                 140                 


Asp Tyr Ser Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala 
145                 150                 155                 160 


Glu Asp Phe Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  141
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  141

Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr 
1               5                   10                  15      


His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met 
            20                  25                  30          


Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu 
        35                  40                  45              


Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile 
    50                  55                  60                  


Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His 
65                  70                  75                  80  


Thr Gln Ala Thr Asn 
                85  


<210>  142
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  142

Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val Glu Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe Pro Pro Val 
            20                  25                  30          


Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr Glu Gly Val 
        35                  40                  45              


Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe His Lys Phe 
    50                  55                  60                  


His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  143
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  143

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Ser Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


Gln Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  144
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn 
                85          


<210>  145
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  145

Glu Val Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Val Asn Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val 
        35                  40                  45              


Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile 
    50                  55                  60                  


Ser Tyr Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  146
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  146

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Phe Tyr 
1               5                   10                  15      


Gln Ser His Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Glu Phe Tyr Val Asp Leu Glu Thr Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Met Phe Ser Lys Phe Ile Ser Phe Asp Pro Gln Ser Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Gly Lys His Thr Leu Glu Phe Met Met Arg Gln Ser 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Phe Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


His Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Glu Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  147
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  147

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Phe Tyr 
1               5                   10                  15      


Gln Ser His Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Glu Phe Tyr Val Asp Leu Glu Thr Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Met Phe Ser Lys Phe Ile Ser Phe Asp Pro Gln Ser Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Gly Lys His Thr Leu Glu Phe Met Met Arg Gln Ser 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn 
                85          


<210>  148
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  148

Glu Val Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Val Asn Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val 
        35                  40                  45              


Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile 
    50                  55                  60                  


Ser Tyr Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  149
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  149

Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His 
            20                  25                  30          


Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro 
                85                  90                  95      


Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn 
            100                 105                 110         


Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val 
        115                 120                 125             


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr 
    130                 135                 140                 


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
145                 150                 155                 160 


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
                165                 170                 175     


Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
            180                 185                 190         


Ser Ala Gln Ser Lys 
        195         


<210>  150
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  150

Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His 
            20                  25                  30          


Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
                85                  90                  


<210>  151
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  151

Tyr Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  152
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  152

Asp Thr Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn 
            20                  25                  30          


Gln Glu Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro 
                85                  90                  95      


Gln Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn 
            100                 105                 110         


Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val 
        115                 120                 125             


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr 
    130                 135                 140                 


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
145                 150                 155                 160 


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
                165                 170                 175     


Pro Ser Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
            180                 185                 190         


Ser Ala Gln Ser Lys 
        195         


<210>  153
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  153

Asp Thr Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn 
            20                  25                  30          


Gln Glu Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
                85                  90                  


<210>  154
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  154

His Pro Gln Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  155
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  155

Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Gln Pro Arg 
1               5                   10                  15      


Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu Glu Tyr Ala 
        35                  40                  45              


Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Arg 
65                  70                  75                  80  


Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr Gly Val Val 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val Thr Val Tyr 
            100                 105                 110         


Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser 
        115                 120                 125             


Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn 
    130                 135                 140                 


Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn 
145                 150                 155                 160 


Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg 
                165                 170                 175     


Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Met Met Ser 
            180                 185                 190         


Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala Gln Ser Lys 
        195                 200                 205             


<210>  156
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  156

Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Gln Pro Arg 
1               5                   10                  15      


Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu Glu Tyr Ala 
        35                  40                  45              


Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Arg 
65                  70                  75                  80  


Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr Gly Val Val 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val 
            100                 105 


<210>  157
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  157

Gln Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  158
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Arg Pro Arg 
1               5                   10                  15      


Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu Glu Asp Leu 
        35                  40                  45              


Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe Leu Glu Asp 
65                  70                  75                  80  


Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val Thr Val Tyr 
            100                 105                 110         


Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu Val Cys Ser 
        115                 120                 125             


Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn 
    130                 135                 140                 


Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn 
145                 150                 155                 160 


Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg 
                165                 170                 175     


Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser 
            180                 185                 190         


Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser 
        195                 200                 205         


<210>  159
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Arg Pro Arg 
1               5                   10                  15      


Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu Glu Asp Leu 
        35                  40                  45              


Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe Leu Glu Asp 
65                  70                  75                  80  


Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val 
            100                 105 


<210>  160
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  160

Glu Pro Lys Val Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser 
            100         


<210>  161
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  161

Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp Asp Ala 
1               5                   10                  15      


Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys Asp Leu 
            20                  25                  30          


Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys Glu Phe 
        35                  40                  45              


Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu Asn Gln 
    50                  55                  60                  


Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn Cys Ala 
65                  70                  75                  80  


Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr Arg Pro 
                85                  90                  95      


Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg Glu Pro 
            100                 105                 110         


Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu Val Thr 
        115                 120                 125             


Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser Ser Ala 
    130                 135                 140                 


His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr Leu Ser 
145                 150                 155                 160 


His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys Val Val 
                165                 170                 175     


Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp 
            180                 185                 


<210>  162
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  162

Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp Asp Ala 
1               5                   10                  15      


Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys Asp Leu 
            20                  25                  30          


Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys Glu Phe 
        35                  40                  45              


Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu Asn Gln 
    50                  55                  60                  


Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn Cys Ala 
65                  70                  75                  80  


Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
                85                  90                  


<210>  163
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  163

Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
1               5                   10                  15      


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
            20                  25                  30          


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
        35                  40                  45              


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
    50                  55                  60                  


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
65                  70                  75                  80  


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp 
                85                  90                  95  


<210>  164
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  164

Thr Asp Ser Pro Glu Asp Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Lys Val Gln Phe Val Val Arg Phe Ile Phe 
            20                  25                  30          


Asn Leu Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Met Phe Val 
        35                  40                  45              


Ala Leu Thr Lys Leu Gly Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg 
    50                  55                  60                  


Leu Asp Leu Leu Glu Arg Ser Arg Gln Ala Val Asp Gly Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Arg Leu Gly Ala Pro Phe Thr Val Gly Arg Lys Val Gln 
                85                  90                  95      


Pro Glu Val Thr Val Tyr Pro Glu Arg Thr Pro Leu Leu His Gln His 
            100                 105                 110         


Asn Leu Leu His Cys Ser Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys 
        115                 120                 125             


Ile Lys Trp Phe Leu Asn Gly Gln Glu Glu Arg Ala Gly Val Met Ser 
    130                 135                 140                 


Thr Gly Pro Ile Arg Asn Gly Asp Trp Thr Phe Gln Thr Val Val Met 
145                 150                 155                 160 


Leu Glu Met Thr Pro Glu Leu Gly His Val Tyr Thr Cys Leu Val Asp 
                165                 170                 175     


His Ser Ser Leu Leu Ser Pro Val Ser Val Glu Trp 
            180                 185             


<210>  165
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  165

Thr Asp Ser Pro Glu Asp Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Lys Val Gln Phe Val Val Arg Phe Ile Phe 
            20                  25                  30          


Asn Leu Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Met Phe Val 
        35                  40                  45              


Ala Leu Thr Lys Leu Gly Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg 
    50                  55                  60                  


Leu Asp Leu Leu Glu Arg Ser Arg Gln Ala Val Asp Gly Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Arg Leu Gly Ala Pro Phe Thr Val Gly Arg Lys 
                85                  90                  


<210>  166
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  166

Val Gln Pro Glu Val Thr Val Tyr Pro Glu Arg Thr Pro Leu Leu His 
1               5                   10                  15      


Gln His Asn Leu Leu His Cys Ser Val Thr Gly Phe Tyr Pro Gly Asp 
            20                  25                  30          


Ile Lys Ile Lys Trp Phe Leu Asn Gly Gln Glu Glu Arg Ala Gly Val 
        35                  40                  45              


Met Ser Thr Gly Pro Ile Arg Asn Gly Asp Trp Thr Phe Gln Thr Val 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Glu Leu Gly His Val Tyr Thr Cys Leu 
65                  70                  75                  80  


Val Asp His Ser Ser Leu Leu Ser Pro Val Ser Val Glu Trp 
                85                  90                  


<210>  167
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  167

Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          


Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              


Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  


Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  


Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg 
                85                  90                  95      


Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu 
            100                 105                 110         


Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg 
        115                 120                 125             


Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn 
    130                 135                 140                 


Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu 
145                 150                 155                 160 


Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr 
                165                 170                 175     


Ser Leu Asp Ser Pro Val Thr Val Glu Trp 
            180                 185     


<210>  168
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  168

Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          


Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              


Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  


Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  


Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg 
                85                  90          


<210>  169
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  169

Val Gln Pro Arg Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln 
1               5                   10                  15      


His His Asn Leu Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser 
            20                  25                  30          


Ile Gln Val Arg Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val 
        35                  40                  45              


Val Ser Thr Asn Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln 
65                  70                  75                  80  


Val Glu His Thr Ser Leu Asp Ser Pro Val Thr Val Glu Trp 
                85                  90                  


<210>  170
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  170

Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
            20                  25                  30          


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
        35                  40                  45              


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
                85                  90                  95      


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
    130                 135                 140                 


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
145                 150                 155                 160 


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
                165                 170                 175     


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp 
            180                 185             


<210>  171
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  171

Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
            20                  25                  30          


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
        35                  40                  45              


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg 
                85                  90                  


<210>  172
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  172

Val Glu Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn 
1               5                   10                  15      


His His Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln 
            20                  25                  30          


Ile Lys Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val 
        35                  40                  45              


Val Ser Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His 
65                  70                  75                  80  


Val Glu His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp 
                85                  90                  


<210>  173
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  173

Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr 
1               5                   10                  15      


Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
            20                  25                  30          


Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu Leu 
        35                  40                  45              


Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu Gln 
    50                  55                  60                  


Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala Glu 
65                  70                  75                  80  


Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile Ser 
                85                  90                  95      


Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser 
            100                 105                 110         


Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg Asn 
        115                 120                 125             


Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg Asn 
    130                 135                 140                 


Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro Gln 
145                 150                 155                 160 


Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln Ser 
                165                 170                 175     


Pro Ile Thr Val Glu Trp 
            180         


<210>  174
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr 
1               5                   10                  15      


Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
            20                  25                  30          


Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu Leu 
        35                  40                  45              


Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu Gln 
    50                  55                  60                  


Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala Glu 
65                  70                  75                  80  


Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val 
                85                  90              


<210>  175
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  175

Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu 
1               5                   10                  15      


Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp 
            20                  25                  30          


Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu 
        35                  40                  45              


Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile 
    50                  55                  60                  


Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser 
65                  70                  75                  80  


Leu Gln Ser Pro Ile Thr Val Glu Trp 
                85                  


<210>  176
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  176

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  177
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  177

Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn 
            20                  25                  30          


Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg 
                85                  90          


<210>  178
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  178

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn 
                


<210>  179
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  179

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe 
                85                  90                  95      


Asp Ala Pro Ser Pro Leu Pro Glu Thr 
            100                 105 


<210>  180
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  180

Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210>  181
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  181

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  182
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  182

Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
1               5                   10                  15      


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
            20                  25                  30          


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser 
        35                  40                  45              


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
    50                  55                  60                  


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
65                  70                  75                  80  


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
                85                  90                  95      


Glu Ser Ala Gln Ser Lys Met 
            100             


<210>  183
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  183

Val Glu Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln 
1               5                   10                  15      


His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser 
            20                  25                  30          


Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val 
        35                  40                  45              


Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu 
    50                  55                  60                  


Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln 
65                  70                  75                  80  


Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala 
                85                  90                  95      


Arg Ser Glu Ser Ala Gln Ser Lys Met 
            100                 105 


<210>  184
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytomegalovirus pp65 epitope

<400>  184

Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val His 
1               5                   10                  


<210>  185
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  185

Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn 
            20                  25                  30          


Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg 
                85                  90          


<210>  186
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  186

Val Tyr Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln 
1               5                   10                  15      


His His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Ala Ser 
            20                  25                  30          


Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val 
        35                  40                  45              


Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu 
    50                  55                  60                  


Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln 
65                  70                  75                  80  


Val Glu His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala 
                85                  90                  95      


Arg Ser Glu Ser Ala Gln Ser Lys Met 
            100                 105 


<210>  187
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  187

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  188
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  188

Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn 
            20                  25                  30          


Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro 
                85                  90                  95      


<210>  189
<211>  1485
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1485)

<400>  189
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt gca cct act tca agt tct aca aag aaa aca cag cta         96
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu           
            20                  25                  30                    

caa ctg gag gca tta ctg ctg gat tta cag atg att ttg aat gga att        144
Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile           
        35                  40                  45                        

aat aat tac aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt        192
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe           
    50                  55                  60                            

tac atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa        240
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu           
65                  70                  75                  80            

gaa gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa        288
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys           
                85                  90                  95                

aac ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata        336
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile           
            100                 105                 110                   

gtt ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct        384
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala           
        115                 120                 125                       

gat gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt        432
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe           
    130                 135                 140                           

tgt caa agc atc atc tca aca ctg act gga ggc gga gga tct ggt ggt        480
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly           
145                 150                 155                 160           

gga ggt tct ggt ggt ggg gga tct gga ggc gga gga tct gca cct act        528
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr           
                165                 170                 175               

tca agt tct aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg        576
Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu           
            180                 185                 190                   

gat tta cag atg att ttg aat gga att aat aat tac aag aat ccc aaa        624
Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys           
        195                 200                 205                       

ctc acc agg atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca        672
Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr           
    210                 215                 220                           

gaa ctg aaa cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag        720
Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu           
225                 230                 235                 240           

gaa gtg cta aat tta gct caa agc aaa aac ttt cac tta aga ccc agg        768
Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg           
                245                 250                 255               

gac tta atc agc aat atc aac gta ata gtt ctg gaa cta aag gga tct        816
Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser           
            260                 265                 270                   

gaa aca aca ttc atg tgt gaa tat gct gat gag aca gca acc att gta        864
Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val           
        275                 280                 285                       

gaa ttt ctg aac aga tgg att acc ttt tgt caa agc atc atc tca aca        912
Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr           
    290                 295                 300                           

ctg act gga ggc gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga        960
Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
305                 310                 315                 320           

tct gga ggc gga gga tct gtt gag cct aag gtg act gtg tat cct tca       1008
Ser Gly Gly Gly Gly Ser Val Glu Pro Lys Val Thr Val Tyr Pro Ser           
                325                 330                 335               

aag acc cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg agt       1056
Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser           
            340                 345                 350                   

ggt ttc tat cca ggc agc att gaa gtc agg tgg ttc cgg aac ggc cag       1104
Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln           
        355                 360                 365                       

gaa gag aag gct ggg gtg gtg tcc aca ggc ctg atc cag aat gga gat       1152
Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp           
    370                 375                 380                           

tgg acc ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga       1200
Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly           
385                 390                 395                 400           

gag gtt tac acc tgc caa gtg gag cac cca agt gtg acg agc cct ctc       1248
Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu           
                405                 410                 415               

aca gtg gaa tgg aga gca cgg tct gaa tct gca cag agc aag atg ggt       1296
Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly           
            420                 425                 430                   

gga ggt ggc tca gga ggc ggc ggc agc ggt gga gga ggg agc ctg gag       1344
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu           
        435                 440                 445                       

atc gag gcc gcc ttc ctg gag cgg gag aac acc gcc ctg gag acc cgg       1392
Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg           
    450                 455                 460                           

gtg gcc gag ctg cgg cag cgg gtg cag cgg ctg cgg aac cgg gtg tcc       1440
Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser           
465                 470                 475                 480           

cag tac cgg acc cgg tac ggc ccc ctg ggc ggc ggc aag tag tga           1485
Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys                       
                485                 490                                   


<210>  190
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Val Glu Pro Lys Val Thr Val Tyr Pro Ser 
                325                 330                 335     


Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser 
            340                 345                 350         


Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln 
        355                 360                 365             


Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp 
    370                 375                 380                 


Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly 
385                 390                 395                 400 


Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu 
                405                 410                 415     


Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
        435                 440                 445             


Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg 
    450                 455                 460                 


Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser 
465                 470                 475                 480 


Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
                485                 490             


<210>  191
<211>  1923
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1923)

<400>  191
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gta aaa cag aat acc ctg aaa ttg gca         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

aca gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc ggc        144
Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        35                  40                  45                        

ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa tgt        192
Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys           
    50                  55                  60                            

cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc atc        240
His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile           
65                  70                  75                  80            

tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag tac        288
Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr           
                85                  90                  95                

cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac agc        336
Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser           
            100                 105                 110                   

cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac tgc        384
Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys           
        115                 120                 125                       

aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg ggt ggt        432
Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly Gly           
    130                 135                 140                           

gga ggt tca atc aaa gaa gaa cat gtg atc atc cag gcc gag ttc tat        480
Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr           
145                 150                 155                 160           

ctg aat cct gac caa tca ggc gag ttt atg ttt gac ttt gat ggt gat        528
Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp           
                165                 170                 175               

gag att ttc cat gtg gat atg gca aag aag gag acg gtc tgg cgg ctt        576
Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu           
            180                 185                 190                   

gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa ggt gca ttg gcc        624
Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala           
        195                 200                 205                       

aac ata gct gtg gac aaa gcc aac ctg gaa atc atg aca aag cgc tcc        672
Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser           
    210                 215                 220                           

aac tat act ccg atc acc aat gta cct cca gag gta act gtg ctc aca        720
Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr           
225                 230                 235                 240           

aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc atc tgt ttc ata        768
Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile           
                245                 250                 255               

gac aag ttc acc cca cca gtg gtc aat gtc acg tgg ctt cga aat gga        816
Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly           
            260                 265                 270                   

aaa cct gtc acc aca gga gtg tca gag aca gtc ttc ctg ccc agg gaa        864
Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu           
        275                 280                 285                       

gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc ctg ccc tca act        912
Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr           
    290                 295                 300                           

gag gac gtt tac gac tgc agg gtg gag cac tgg ggc ttg gat gag cct        960
Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro           
305                 310                 315                 320           

ctt ctc aag cac tgg gag ttt gat gct cca agc cct ctc cca gag act       1008
Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr           
                325                 330                 335               

ggt gga ggt ggc tca gga ggc ggc ggc agc ctg gag atc cgg gcc gcc       1056
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala Ala           
            340                 345                 350                   

ttc ctg cgg cag cgg aac acc gcc ctg cgg acc gag gtg gcc gag ctg       1104
Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu           
        355                 360                 365                       

gag cag gag gtg cag cgg ctg gag aac gag gtg tcc cag tac gag acc       1152
Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr           
    370                 375                 380                           

cgg tac ggc ccc ctg ggc ggc ggc aag ggc gga tca gca gct gcg ggt       1200
Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala Gly           
385                 390                 395                 400           

ggc gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg       1248
Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu           
                405                 410                 415               

ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc       1296
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
            420                 425                 430                   

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc       1344
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
        435                 440                 445                       

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       1392
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
    450                 455                 460                           

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac gca agc acg       1440
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr           
465                 470                 475                 480           

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       1488
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
                485                 490                 495               

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc       1536
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro           
            500                 505                 510                   

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       1584
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
        515                 520                 525                       

gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc       1632
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val           
    530                 535                 540                           

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       1680
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
545                 550                 555                 560           

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       1728
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
                565                 570                 575               

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       1776
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
            580                 585                 590                   

gtg gac aag agc aga tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       1824
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
        595                 600                 605                       

atg cac gag gct ctg cac aac cac tac acg cag aag tcc ctc tcc ctg       1872
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
    610                 615                 620                           

tct ccg ggt aaa ggc gga tca cat cac cat cac cat cac cat cac tag       1920
Ser Pro Gly Lys Gly Gly Ser His His His His His His His His               
625                 630                 635                               

tga                                                                   1923


<210>  192
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys 
    50                  55                  60                  


His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
                85                  90                  95      


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly Gly 
    130                 135                 140                 


Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr 
145                 150                 155                 160 


Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp 
                165                 170                 175     


Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu 
            180                 185                 190         


Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala 
        195                 200                 205             


Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser 
    210                 215                 220                 


Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr 
225                 230                 235                 240 


Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile 
                245                 250                 255     


Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly 
            260                 265                 270         


Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu 
        275                 280                 285             


Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr 
    290                 295                 300                 


Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro 
305                 310                 315                 320 


Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala Ala 
            340                 345                 350         


Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu 
        355                 360                 365             


Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr 
    370                 375                 380                 


Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala Gly 
385                 390                 395                 400 


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                405                 410                 415     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            420                 425                 430         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        435                 440                 445             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    450                 455                 460                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
465                 470                 475                 480 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                485                 490                 495     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            500                 505                 510         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        515                 520                 525             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    530                 535                 540                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
545                 550                 555                 560 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                565                 570                 575     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            580                 585                 590         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        595                 600                 605             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    610                 615                 620                 


Ser Pro Gly Lys Gly Gly Ser His His His His His His His His 
625                 630                 635                 


<210>  193
<211>  2139
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2139)

<400>  193
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gta aaa cag aat acc ctg aaa ttg gca         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

aca gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc ggc        144
Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        35                  40                  45                        

ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa tgt        192
Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys           
    50                  55                  60                            

cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc atc        240
His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile           
65                  70                  75                  80            

tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag tac        288
Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr           
                85                  90                  95                

cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac agc        336
Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser           
            100                 105                 110                   

cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac tgc        384
Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys           
        115                 120                 125                       

aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg cga gtt        432
Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val           
    130                 135                 140                           

gag cct ggt ggt gga ggt tca atc aaa gaa gaa cat gtg atc atc cag        480
Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln           
145                 150                 155                 160           

gcc gag ttc tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac        528
Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp           
                165                 170                 175               

ttt gat ggt gat gag att ttc cat gtg gat atg gca aag aag gag acg        576
Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr           
            180                 185                 190                   

gtc tgg cgg ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa        624
Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln           
        195                 200                 205                       

ggt gca ttg gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg        672
Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met           
    210                 215                 220                           

aca aag cgc tcc aac tat act ccg atc acc aat gta cct cca gag gta        720
Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val           
225                 230                 235                 240           

act gtg ctc aca aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc        768
Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu           
                245                 250                 255               

atc tgt ttc ata gac aag ttc acc cca cca gtg gtc aat gtc acg tgg        816
Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp           
            260                 265                 270                   

ctt cga aat gga aaa cct gtc acc aca gga gtg tca gag aca gtc ttc        864
Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe           
        275                 280                 285                       

ctg ccc agg gaa gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc        912
Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe           
    290                 295                 300                           

ctg ccc tca act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc        960
Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly           
305                 310                 315                 320           

ttg gat gag cct ctt ctc aag cac tgg gag ttt gat gct gga ggc gga       1008
Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly           
                325                 330                 335               

gga tct gga ggc gga gga tct aag gtg act gtg tat cct tca aag acc       1056
Gly Ser Gly Gly Gly Gly Ser Lys Val Thr Val Tyr Pro Ser Lys Thr           
            340                 345                 350                   

cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg agt ggt ttc       1104
Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe           
        355                 360                 365                       

tat cca ggc agc att gaa gtc agg tgg ttc cgg aac ggc cag gaa gag       1152
Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu           
    370                 375                 380                           

aag gct ggg gtg gtg tcc aca ggc ctg atc cag aat gga gat tgg acc       1200
Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr           
385                 390                 395                 400           

ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga gag gtt       1248
Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val           
                405                 410                 415               

tac acc tgc caa gtg gag cac cca agt gtg acg agc cct ctc aca gtg       1296
Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val           
            420                 425                 430                   

gaa tgg aga gca cgg tct gga ggc gga gga tct gga ggc gga gga tct       1344
Glu Trp Arg Ala Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
        435                 440                 445                       

ggt ggt gga ggt tct ggt ggt ggg gga tct gga ggc gga gga tct gga       1392
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
    450                 455                 460                           

ggc gga gga tct gca gct gcg ggt ggc gac aaa act cac aca tgc cca       1440
Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro           
465                 470                 475                 480           

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc       1488
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
                485                 490                 495               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       1536
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            500                 505                 510                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       1584
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        515                 520                 525                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       1632
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    530                 535                 540                           

cgg gag gag cag tac gca agc acg tac cgt gtg gtc agc gtc ctc acc       1680
Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
545                 550                 555                 560           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1728
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                565                 570                 575               

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc       1776
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
            580                 585                 590                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1824
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        595                 600                 605                       

gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1872
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    610                 615                 620                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1920
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
625                 630                 635                 640           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1968
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                645                 650                 655               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc aga tgg cag cag       2016
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            660                 665                 670                   

ggg aac gtc ttc tca tgc tcc gtg atg cac gag gct ctg cac aac cac       2064
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        675                 680                 685                       

tac acg cag aag tcc ctc tcc ctg tct ccg ggt aaa ggc gga tca cat       2112
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser His           
    690                 695                 700                           

cac cat cac cat cac cat cac tag tga                                   2139
His His His His His His His                                               
705                 710                                                   


<210>  194
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys 
    50                  55                  60                  


His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
                85                  90                  95      


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
    130                 135                 140                 


Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln 
145                 150                 155                 160 


Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp 
                165                 170                 175     


Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr 
            180                 185                 190         


Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln 
        195                 200                 205             


Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met 
    210                 215                 220                 


Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val 
225                 230                 235                 240 


Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu 
                245                 250                 255     


Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp 
            260                 265                 270         


Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe 
        275                 280                 285             


Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe 
    290                 295                 300                 


Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Lys Val Thr Val Tyr Pro Ser Lys Thr 
            340                 345                 350         


Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe 
        355                 360                 365             


Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu 
    370                 375                 380                 


Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr 
385                 390                 395                 400 


Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val 
                405                 410                 415     


Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val 
            420                 425                 430         


Glu Trp Arg Ala Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro 
465                 470                 475                 480 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                485                 490                 495     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            500                 505                 510         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        515                 520                 525             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    530                 535                 540                 


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
545                 550                 555                 560 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                565                 570                 575     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            580                 585                 590         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        595                 600                 605             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    610                 615                 620                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
625                 630                 635                 640 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                645                 650                 655     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            660                 665                 670         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        675                 680                 685             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser His 
    690                 695                 700                 


His His His His His His His 
705                 710     


<210>  195
<211>  2982
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2982)

<400>  195
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gta aaa cag aat acc ctg aaa ttg gca         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

aca gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc ggc        144
Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        35                  40                  45                        

ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa tgt        192
Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys           
    50                  55                  60                            

cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc atc        240
His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile           
65                  70                  75                  80            

tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag tac        288
Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr           
                85                  90                  95                

cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac agc        336
Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser           
            100                 105                 110                   

cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac tgc        384
Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys           
        115                 120                 125                       

aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg cga gtt        432
Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val           
    130                 135                 140                           

gag cct ggt ggt gga ggt tca atc aaa gaa gaa cat gtg atc atc cag        480
Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln           
145                 150                 155                 160           

gcc gag ttc tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac        528
Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp           
                165                 170                 175               

ttt gat ggt gat gag att ttc cat gtg gat atg gca aag aag gag acg        576
Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr           
            180                 185                 190                   

gtc tgg cgg ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa        624
Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln           
        195                 200                 205                       

ggt gca ttg gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg        672
Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met           
    210                 215                 220                           

aca aag cgc tcc aac tat act ccg atc acc aat gta cct cca gag gta        720
Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val           
225                 230                 235                 240           

act gtg ctc aca aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc        768
Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu           
                245                 250                 255               

atc tgt ttc ata gac aag ttc acc cca cca gtg gtc aat gtc acg tgg        816
Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp           
            260                 265                 270                   

ctt cga aat gga aaa cct gtc acc aca gga gtg tca gag aca gtc ttc        864
Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe           
        275                 280                 285                       

ctg ccc agg gaa gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc        912
Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe           
    290                 295                 300                           

ctg ccc tca act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc        960
Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly           
305                 310                 315                 320           

ttg gat gag cct ctt ctc aag cac tgg gag ttt gat gct gga ggc gga       1008
Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly           
                325                 330                 335               

gga tct gga ggc gga gga tct aag gtg act gtg tat cct tca aag acc       1056
Gly Ser Gly Gly Gly Gly Ser Lys Val Thr Val Tyr Pro Ser Lys Thr           
            340                 345                 350                   

cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg agt ggt ttc       1104
Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe           
        355                 360                 365                       

tat cca ggc agc att gaa gtc agg tgg ttc cgg aac ggc cag gaa gag       1152
Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu           
    370                 375                 380                           

aag gct ggg gtg gtg tcc aca ggc ctg atc cag aat gga gat tgg acc       1200
Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr           
385                 390                 395                 400           

ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga gag gtt       1248
Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val           
                405                 410                 415               

tac acc tgc caa gtg gag cac cca agt gtg acg agc cct ctc aca gtg       1296
Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val           
            420                 425                 430                   

gaa tgg aga gca cgg tct gga ggc gga gga tct ggt ggt gga ggt tct       1344
Glu Trp Arg Ala Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
        435                 440                 445                       

ggt ggt ggg gga tct gga ggc gga gga tct gca cct act tca agt tct       1392
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser           
    450                 455                 460                           

aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg gat tta cag       1440
Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln           
465                 470                 475                 480           

atg att ttg aat gga att aat aat tac aag aat ccc aaa ctc acc agg       1488
Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg           
                485                 490                 495               

atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca gaa ctg aaa       1536
Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys           
            500                 505                 510                   

cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag gaa gtg cta       1584
His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu           
        515                 520                 525                       

aat tta gct caa agc aaa aac ttt cac tta aga ccc agg gac tta atc       1632
Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile           
    530                 535                 540                           

agc aat atc aac gta ata gtt ctg gaa cta aag gga tct gaa aca aca       1680
Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr           
545                 550                 555                 560           

ttc atg tgt gaa tat gct gat gag aca gca acc att gta gaa ttt ctg       1728
Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu           
                565                 570                 575               

aac aga tgg att acc ttt tgt caa agc atc atc tca aca ctg act gga       1776
Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly           
            580                 585                 590                   

ggc gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga tct gga ggc       1824
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
        595                 600                 605                       

gga gga tct gca cct act tca agt tct aca aag aaa aca cag cta caa       1872
Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln           
    610                 615                 620                           

ctg gag gca tta ctg ctg gat tta cag atg att ttg aat gga att aat       1920
Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn           
625                 630                 635                 640           

aat tac aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt tac       1968
Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr           
                645                 650                 655               

atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa gaa       2016
Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu           
            660                 665                 670                   

gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa aac       2064
Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn           
        675                 680                 685                       

ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata gtt       2112
Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val           
    690                 695                 700                           

ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct gat       2160
Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp           
705                 710                 715                 720           

gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt tgt       2208
Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys           
                725                 730                 735               

caa agc atc atc tca aca ctg act gga ggc gga gga tct gca gct gcg       2256
Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ala Ala Ala           
            740                 745                 750                   

ggt ggc gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc       2304
Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu           
        755                 760                 765                       

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc       2352
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
    770                 775                 780                           

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg       2400
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
785                 790                 795                 800           

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg       2448
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val           
                805                 810                 815               

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac gca agc       2496
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser           
            820                 825                 830                   

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg       2544
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu           
        835                 840                 845                       

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc       2592
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala           
    850                 855                 860                           

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca       2640
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro           
865                 870                 875                 880           

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag       2688
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
                885                 890                 895               

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc       2736
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
            900                 905                 910                   

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg       2784
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
        915                 920                 925                       

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc       2832
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
    930                 935                 940                           

acc gtg gac aag agc aga tgg cag cag ggg aac gtc ttc tca tgc tcc       2880
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
945                 950                 955                 960           

gtg atg cac gag gct ctg cac aac cac tac acg cag aag tcc ctc tcc       2928
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
                965                 970                 975               

ctg tct ccg ggt aaa ggc gga tca cat cac cat cac cat cac cat cac       2976
Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His           
            980                 985                 990                   

tag tga                                                               2982


<210>  196
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys 
    50                  55                  60                  


His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
                85                  90                  95      


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
    130                 135                 140                 


Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln 
145                 150                 155                 160 


Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp 
                165                 170                 175     


Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr 
            180                 185                 190         


Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln 
        195                 200                 205             


Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met 
    210                 215                 220                 


Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val 
225                 230                 235                 240 


Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu 
                245                 250                 255     


Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp 
            260                 265                 270         


Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe 
        275                 280                 285             


Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe 
    290                 295                 300                 


Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Lys Val Thr Val Tyr Pro Ser Lys Thr 
            340                 345                 350         


Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe 
        355                 360                 365             


Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu 
    370                 375                 380                 


Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr 
385                 390                 395                 400 


Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val 
                405                 410                 415     


Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val 
            420                 425                 430         


Glu Trp Arg Ala Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser 
    450                 455                 460                 


Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln 
465                 470                 475                 480 


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                485                 490                 495     


Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            500                 505                 510         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        515                 520                 525             


Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile 
    530                 535                 540                 


Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr 
545                 550                 555                 560 


Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu 
                565                 570                 575     


Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
    610                 615                 620                 


Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
625                 630                 635                 640 


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr 
                645                 650                 655     


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
            660                 665                 670         


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
        675                 680                 685             


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
    690                 695                 700                 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
705                 710                 715                 720 


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
                725                 730                 735     


Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ala Ala Ala 
            740                 745                 750         


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        755                 760                 765             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    770                 775                 780                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
785                 790                 795                 800 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                805                 810                 815     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
            820                 825                 830         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        835                 840                 845             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    850                 855                 860                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
865                 870                 875                 880 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                885                 890                 895     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            900                 905                 910         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        915                 920                 925             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    930                 935                 940                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
945                 950                 955                 960 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                965                 970                 975     


Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His 
            980                 985                 990         


<210>  197
<211>  2667
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2667)

<400>  197
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gta aaa cag aat acc ctg aaa ttg gca         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

aca gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc ggc        144
Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        35                  40                  45                        

ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa tgt        192
Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys           
    50                  55                  60                            

cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc atc        240
His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile           
65                  70                  75                  80            

tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag tac        288
Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr           
                85                  90                  95                

cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac agc        336
Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser           
            100                 105                 110                   

cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac tgc        384
Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys           
        115                 120                 125                       

aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg cga gtt        432
Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val           
    130                 135                 140                           

gag cct ggt ggt gga ggt tca atc aaa gaa gaa cat gtg atc atc cag        480
Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln           
145                 150                 155                 160           

gcc gag ttc tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac        528
Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp           
                165                 170                 175               

ttt gat ggt gat gag att ttc cat gtg gat atg gca aag aag gag acg        576
Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr           
            180                 185                 190                   

gtc tgg cgg ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa        624
Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln           
        195                 200                 205                       

ggt gca ttg gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg        672
Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met           
    210                 215                 220                           

aca aag cgc tcc aac tat act ccg atc acc aat gta cct cca gag gta        720
Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val           
225                 230                 235                 240           

act gtg ctc aca aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc        768
Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu           
                245                 250                 255               

atc tgt ttc ata gac aag ttc acc cca cca gtg gtc aat gtc acg tgg        816
Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp           
            260                 265                 270                   

ctt cga aat gga aaa cct gtc acc aca gga gtg tca gag aca gtc ttc        864
Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe           
        275                 280                 285                       

ctg ccc agg gaa gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc        912
Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe           
    290                 295                 300                           

ctg ccc tca act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc        960
Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly           
305                 310                 315                 320           

ttg gat gag cct ctt ctc aag cac tgg gag ttt gat gct gga ggc gga       1008
Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly           
                325                 330                 335               

gga tct ggt ggt gga ggt tct ggt ggt ggg gga tct gga ggc gga gga       1056
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            340                 345                 350                   

tct gca cct act tca agt tct aca aag aaa aca cag cta caa ctg gag       1104
Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu           
        355                 360                 365                       

gca tta ctg ctg gat tta cag atg att ttg aat gga att aat aat tac       1152
Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr           
    370                 375                 380                           

aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt tac atg ccc       1200
Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro           
385                 390                 395                 400           

aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa gaa gaa ctc       1248
Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu           
                405                 410                 415               

aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa aac ttt cac       1296
Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His           
            420                 425                 430                   

tta aga ccc agg gac tta atc agc aat atc aac gta ata gtt ctg gaa       1344
Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu           
        435                 440                 445                       

cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct gat gag aca       1392
Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr           
    450                 455                 460                           

gca acc att gta gaa ttt ctg aac aga tgg att acc ttt tgt caa agc       1440
Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser           
465                 470                 475                 480           

atc atc tca aca ctg act gga ggc gga gga tct ggt ggt gga ggt tct       1488
Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
                485                 490                 495               

ggt ggt ggg gga tct gga ggc gga gga tct gca cct act tca agt tct       1536
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser           
            500                 505                 510                   

aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg gat tta cag       1584
Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln           
        515                 520                 525                       

atg att ttg aat gga att aat aat tac aag aat ccc aaa ctc acc agg       1632
Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg           
    530                 535                 540                           

atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca gaa ctg aaa       1680
Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys           
545                 550                 555                 560           

cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag gaa gtg cta       1728
His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu           
                565                 570                 575               

aat tta gct caa agc aaa aac ttt cac tta aga ccc agg gac tta atc       1776
Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile           
            580                 585                 590                   

agc aat atc aac gta ata gtt ctg gaa cta aag gga tct gaa aca aca       1824
Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr           
        595                 600                 605                       

ttc atg tgt gaa tat gct gat gag aca gca acc att gta gaa ttt ctg       1872
Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu           
    610                 615                 620                           

aac aga tgg att acc ttt tgt caa agc atc atc tca aca ctg act gga       1920
Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly           
625                 630                 635                 640           

ggc gga gga tct gca gct gcg ggt ggc gac aaa act cac aca tgc cca       1968
Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro           
                645                 650                 655               

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc       2016
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
            660                 665                 670                   

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc       2064
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
        675                 680                 685                       

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc       2112
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
    690                 695                 700                           

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg       2160
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
705                 710                 715                 720           

cgg gag gag cag tac gca agc acg tac cgt gtg gtc agc gtc ctc acc       2208
Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
                725                 730                 735               

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       2256
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
            740                 745                 750                   

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc       2304
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
        755                 760                 765                       

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       2352
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
    770                 775                 780                           

gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       2400
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
785                 790                 795                 800           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       2448
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
                805                 810                 815               

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       2496
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
            820                 825                 830                   

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc aga tgg cag cag       2544
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
        835                 840                 845                       

ggg aac gtc ttc tca tgc tcc gtg atg cac gag gct ctg cac aac cac       2592
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
    850                 855                 860                           

tac acg cag aag tcc ctc tcc ctg tct ccg ggt aaa ggc gga tca cat       2640
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser His           
865                 870                 875                 880           

cac cat cac cat cac cat cac tag tga                                   2667
His His His His His His His                                               
                885                                                       


<210>  198
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys 
    50                  55                  60                  


His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
                85                  90                  95      


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
    130                 135                 140                 


Glu Pro Gly Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln 
145                 150                 155                 160 


Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp 
                165                 170                 175     


Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr 
            180                 185                 190         


Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln 
        195                 200                 205             


Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met 
    210                 215                 220                 


Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val 
225                 230                 235                 240 


Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu 
                245                 250                 255     


Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp 
            260                 265                 270         


Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe 
        275                 280                 285             


Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe 
    290                 295                 300                 


Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
        355                 360                 365             


Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
    370                 375                 380                 


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro 
385                 390                 395                 400 


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
                405                 410                 415     


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
            420                 425                 430         


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
        435                 440                 445             


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
    450                 455                 460                 


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
465                 470                 475                 480 


Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser 
            500                 505                 510         


Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln 
        515                 520                 525             


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
    530                 535                 540                 


Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
545                 550                 555                 560 


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
                565                 570                 575     


Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile 
            580                 585                 590         


Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr 
        595                 600                 605             


Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu 
    610                 615                 620                 


Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro 
                645                 650                 655     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            660                 665                 670         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        675                 680                 685             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    690                 695                 700                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
705                 710                 715                 720 


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                725                 730                 735     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            740                 745                 750         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        755                 760                 765             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    770                 775                 780                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
785                 790                 795                 800 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                805                 810                 815     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            820                 825                 830         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        835                 840                 845             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    850                 855                 860                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser His 
865                 870                 875                 880 


His His His His His His His 
                885         


<210>  199
<211>  1926
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1926)

<400>  199
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ctt ccg ctc aaa atg ctt aac ata cct tcc att aat         96
Val Thr Asn Ser Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn           
            20                  25                  30                    

gtc cac gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc        144
Val His Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly           
        35                  40                  45                        

ggc ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa        192
Gly Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu           
    50                  55                  60                            

tgt cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc        240
Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys           
65                  70                  75                  80            

atc tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag        288
Ile Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu           
                85                  90                  95                

tac cgg gcg gtg acg gag ctg ggg cgg cct gca gcc gag tac tgg aac        336
Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn           
            100                 105                 110                   

agc cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac        384
Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr           
        115                 120                 125                       

tgc aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg ggt        432
Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly           
    130                 135                 140                           

ggt gga ggt tca atc aaa gaa gaa cat gtg atc atc cag gcc gag ttc        480
Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe           
145                 150                 155                 160           

tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac ttt gat ggt        528
Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly           
                165                 170                 175               

gat gag att ttc cat gtg gat atg gca aag aag gag acg gtc tgg cgg        576
Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg           
            180                 185                 190                   

ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa ggt gca ttg        624
Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu           
        195                 200                 205                       

gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg aca aag cgc        672
Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg           
    210                 215                 220                           

tcc aac tat act ccg atc acc aat gta cct cca gag gta act gtg ctc        720
Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu           
225                 230                 235                 240           

aca aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc atc tgt ttc        768
Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe           
                245                 250                 255               

ata gac aag ttc acc cca cca gtg gtc aat gtc acg tgg ctt cga aat        816
Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn           
            260                 265                 270                   

gga aaa cct gtc acc aca gga gtg tca gag aca gtc ttc ctg ccc agg        864
Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg           
        275                 280                 285                       

gaa gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc ctg ccc tca        912
Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser           
    290                 295                 300                           

act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc ttg gat gag        960
Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu           
305                 310                 315                 320           

cct ctt ctc aag cac tgg gag ttt gat gct cca agc cct ctc cca gag       1008
Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu           
                325                 330                 335               

act ggt gga ggt ggc tca gga ggc ggc ggc agc ctg gag atc cgg gcc       1056
Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala           
            340                 345                 350                   

gcc ttc ctg cgg cag cgg aac acc gcc ctg cgg acc gag gtg gcc gag       1104
Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu           
        355                 360                 365                       

ctg gag cag gag gtg cag cgg ctg gag aac gag gtg tcc cag tac gag       1152
Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu           
    370                 375                 380                           

acc cgg tac ggc ccc ctg ggc ggc ggc aag ggc gga tca gca gct gcg       1200
Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala           
385                 390                 395                 400           

ggt ggc gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc       1248
Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu           
                405                 410                 415               

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc       1296
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
            420                 425                 430                   

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg       1344
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
        435                 440                 445                       

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg       1392
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val           
    450                 455                 460                           

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac gca agc       1440
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser           
465                 470                 475                 480           

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg       1488
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu           
                485                 490                 495               

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc       1536
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala           
            500                 505                 510                   

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca       1584
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro           
        515                 520                 525                       

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag       1632
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
    530                 535                 540                           

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc       1680
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
545                 550                 555                 560           

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg       1728
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
                565                 570                 575               

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc       1776
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
            580                 585                 590                   

acc gtg gac aag agc aga tgg cag cag ggg aac gtc ttc tca tgc tcc       1824
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
        595                 600                 605                       

gtg atg cac gag gct ctg cac aac cac tac acg cag aag tcc ctc tcc       1872
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
    610                 615                 620                           

ctg tct ccg ggt aaa ggc gga tca cat cac cat cac cat cac cat cac       1920
Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His           
625                 630                 635                 640           

tag tga                                                               1926


<210>  200
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn 
            20                  25                  30          


Val His Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu 
    50                  55                  60                  


Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys 
65                  70                  75                  80  


Ile Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu 
                85                  90                  95      


Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn 
            100                 105                 110         


Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr 
        115                 120                 125             


Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
145                 150                 155                 160 


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
                165                 170                 175     


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
            180                 185                 190         


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
        195                 200                 205             


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
    210                 215                 220                 


Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu 
225                 230                 235                 240 


Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe 
                245                 250                 255     


Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn 
            260                 265                 270         


Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg 
        275                 280                 285             


Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser 
    290                 295                 300                 


Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu 
305                 310                 315                 320 


Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu 
                325                 330                 335     


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala 
            340                 345                 350         


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
        355                 360                 365             


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
    370                 375                 380                 


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala 
385                 390                 395                 400 


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                405                 410                 415     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            420                 425                 430         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        435                 440                 445             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    450                 455                 460                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
465                 470                 475                 480 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                485                 490                 495     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            500                 505                 510         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        515                 520                 525             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    530                 535                 540                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
545                 550                 555                 560 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                565                 570                 575     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            580                 585                 590         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        595                 600                 605             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    610                 615                 620                 


Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His 
625                 630                 635                 640 


<210>  201
<211>  1926
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1926)

<400>  201
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gtg aaa cag aac acc ctg aaa ctg gcg         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

acc ggt gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc        144
Thr Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly           
        35                  40                  45                        

ggc ggc ggg gac acc cga cca cgt ttc ttg gag cag gtt aaa cat gag        192
Gly Gly Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu           
    50                  55                  60                            

tgt cat ttc ttc aac ggg acg gag cgg gtg cgg ttc ctg gac aga tac        240
Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr           
65                  70                  75                  80            

ttc tat cac caa gag gag tac gtg cgc ttc gac agc gac gtg ggg gag        288
Phe Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu           
                85                  90                  95                

tac cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac        336
Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn           
            100                 105                 110                   

agc cag aag gac ctc ctg gag cag aag cgg gcc gcg gtg gac acc tac        384
Ser Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr           
        115                 120                 125                       

tgc aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg ggt        432
Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly           
    130                 135                 140                           

ggt gga ggt tca atc aaa gaa gaa cat gtg atc atc cag gcc gag ttc        480
Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe           
145                 150                 155                 160           

tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac ttt gat ggt        528
Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly           
                165                 170                 175               

gat gag att ttc cat gtg gat atg gca aag aag gag acg gtc tgg cgg        576
Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg           
            180                 185                 190                   

ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa ggt gca ttg        624
Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu           
        195                 200                 205                       

gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg aca aag cgc        672
Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg           
    210                 215                 220                           

tcc aac tat act ccg atc acc aat gta cct cca gag gta act gtg ctc        720
Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu           
225                 230                 235                 240           

aca aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc atc tgt ttc        768
Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe           
                245                 250                 255               

ata gac aag ttc acc cca cca gtg gtc aat gtc acg tgg ctt cga aat        816
Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn           
            260                 265                 270                   

gga aaa cct gtc acc aca gga gtg tca gag aca gtc ttc ctg ccc agg        864
Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg           
        275                 280                 285                       

gaa gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc ctg ccc tca        912
Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser           
    290                 295                 300                           

act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc ttg gat gag        960
Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu           
305                 310                 315                 320           

cct ctt ctc aag cac tgg gag ttt gat gct cca agc cct ctc cca gag       1008
Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu           
                325                 330                 335               

act ggt gga ggt ggc tca gga ggc ggc ggc agc ctg gag atc cgg gcc       1056
Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala           
            340                 345                 350                   

gcc ttc ctg cgg cag cgg aac acc gcc ctg cgg acc gag gtg gcc gag       1104
Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu           
        355                 360                 365                       

ctg gag cag gag gtg cag cgg ctg gag aac gag gtg tcc cag tac gag       1152
Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu           
    370                 375                 380                           

acc cgg tac ggc ccc ctg ggc ggc ggc aag ggc gga tca gca gct gcg       1200
Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala           
385                 390                 395                 400           

ggt ggc gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc       1248
Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu           
                405                 410                 415               

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc       1296
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
            420                 425                 430                   

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg       1344
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
        435                 440                 445                       

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg       1392
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val           
    450                 455                 460                           

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac gca agc       1440
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser           
465                 470                 475                 480           

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg       1488
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu           
                485                 490                 495               

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc       1536
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala           
            500                 505                 510                   

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca       1584
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro           
        515                 520                 525                       

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag       1632
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
    530                 535                 540                           

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc       1680
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
545                 550                 555                 560           

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg       1728
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
                565                 570                 575               

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc       1776
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
            580                 585                 590                   

acc gtg gac aag agc aga tgg cag cag ggg aac gtc ttc tca tgc tcc       1824
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
        595                 600                 605                       

gtg atg cac gag gct ctg cac aac cac tac acg cag aag tcc ctc tcc       1872
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
    610                 615                 620                           

ctg tct ccg ggt aaa ggc gga tca cat cac cat cac cat cac cat cac       1920
Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His           
625                 630                 635                 640           

tag tga                                                               1926


<210>  202
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu 
    50                  55                  60                  


Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr 
65                  70                  75                  80  


Phe Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu 
                85                  90                  95      


Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn 
            100                 105                 110         


Ser Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr 
        115                 120                 125             


Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
145                 150                 155                 160 


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
                165                 170                 175     


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
            180                 185                 190         


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
        195                 200                 205             


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
    210                 215                 220                 


Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu 
225                 230                 235                 240 


Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe 
                245                 250                 255     


Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn 
            260                 265                 270         


Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg 
        275                 280                 285             


Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser 
    290                 295                 300                 


Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu 
305                 310                 315                 320 


Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu 
                325                 330                 335     


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Arg Ala 
            340                 345                 350         


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
        355                 360                 365             


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
    370                 375                 380                 


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Ala Ala Ala 
385                 390                 395                 400 


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                405                 410                 415     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            420                 425                 430         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        435                 440                 445             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    450                 455                 460                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
465                 470                 475                 480 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                485                 490                 495     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            500                 505                 510         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        515                 520                 525             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    530                 535                 540                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
545                 550                 555                 560 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                565                 570                 575     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            580                 585                 590         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        595                 600                 605             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    610                 615                 620                 


Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His His His 
625                 630                 635                 640 


<210>  203
<211>  1485
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1485)

<400>  203
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt gca cct act tca agt tct aca aag aaa aca cag cta         96
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu           
            20                  25                  30                    

caa ctg gag gca tta ctg ctg gat tta cag atg att ttg aat gga att        144
Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile           
        35                  40                  45                        

aat aat tac aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt        192
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe           
    50                  55                  60                            

tac atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa        240
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu           
65                  70                  75                  80            

gaa gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa        288
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys           
                85                  90                  95                

aac ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata        336
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile           
            100                 105                 110                   

gtt ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct        384
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala           
        115                 120                 125                       

gat gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt        432
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe           
    130                 135                 140                           

tgt caa agc atc atc tca aca ctg act gga ggc gga gga tct ggt ggt        480
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly           
145                 150                 155                 160           

gga ggt tct ggt ggt ggg gga tct gga ggc gga gga tct gca cct act        528
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr           
                165                 170                 175               

tca agt tct aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg        576
Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu           
            180                 185                 190                   

gat tta cag atg att ttg aat gga att aat aat tac aag aat ccc aaa        624
Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys           
        195                 200                 205                       

ctc acc agg atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca        672
Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr           
    210                 215                 220                           

gaa ctg aaa cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag        720
Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu           
225                 230                 235                 240           

gaa gtg cta aat tta gct caa agc aaa aac ttt cac tta aga ccc agg        768
Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg           
                245                 250                 255               

gac tta atc agc aat atc aac gta ata gtt ctg gaa cta aag gga tct        816
Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser           
            260                 265                 270                   

gaa aca aca ttc atg tgt gaa tat gct gat gag aca gca acc att gta        864
Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val           
        275                 280                 285                       

gaa ttt ctg aac aga tgg att acc ttt tgt caa agc atc atc tca aca        912
Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr           
    290                 295                 300                           

ctg act gga ggc gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga        960
Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
305                 310                 315                 320           

tct gga ggc gga gga tct gtc tat cct gag gtg act gtg tat cct gca       1008
Ser Gly Gly Gly Gly Ser Val Tyr Pro Glu Val Thr Val Tyr Pro Ala           
                325                 330                 335               

aag acc cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg aat       1056
Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Asn           
            340                 345                 350                   

ggt ttc tat cca gcc agc att gaa gtc agg tgg ttc cgg aac ggc cag       1104
Gly Phe Tyr Pro Ala Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln           
        355                 360                 365                       

gaa gag aag act ggg gtg gtg tcc aca ggc ctg atc cag aat gga gac       1152
Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp           
    370                 375                 380                           

tgg acc ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga       1200
Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly           
385                 390                 395                 400           

gag gtt tac acc tgc caa gtg gag cac cca agc ctg acg agc cct ctc       1248
Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Thr Ser Pro Leu           
                405                 410                 415               

aca gtg gaa tgg aga gca cgg tct gaa tct gca cag agc aag atg ggt       1296
Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly           
            420                 425                 430                   

gga ggt ggc tca gga ggc ggc ggc agc ggt gga gga ggg agc ctg gag       1344
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu           
        435                 440                 445                       

atc gag gcc gcc ttc ctg gag cgg gag aac acc gcc ctg gag acc cgg       1392
Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg           
    450                 455                 460                           

gtg gcc gag ctg cgg cag cgg gtg cag cgg ctg cgg aac cgg gtg tcc       1440
Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser           
465                 470                 475                 480           

cag tac cgg acc cgg tac ggc ccc ctg ggc ggc ggc aag tag tga           1485
Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys                       
                485                 490                                   


<210>  204
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Val Tyr Pro Glu Val Thr Val Tyr Pro Ala 
                325                 330                 335     


Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Asn 
            340                 345                 350         


Gly Phe Tyr Pro Ala Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln 
        355                 360                 365             


Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp 
    370                 375                 380                 


Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly 
385                 390                 395                 400 


Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Thr Ser Pro Leu 
                405                 410                 415     


Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
        435                 440                 445             


Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg 
    450                 455                 460                 


Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser 
465                 470                 475                 480 


Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
                485                 490             


<210>  205
<211>  1812
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1812)

<400>  205
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt ccg aaa tat gta aaa cag aat acc ctg aaa ttg gca         96
Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala           
            20                  25                  30                    

aca gga ggt ggc gga tcc ggc tcc ggt gga ggt ggc tca gga ggc ggc        144
Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        35                  40                  45                        

ggc ggg gac acc cga cca cgt ttc ttg tgg cag cat aag ttt gaa tgt        192
Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys           
    50                  55                  60                            

cat ttc ttc aat ggg acg gag cgg gtg cgg ttg ctg gaa aga tgc atc        240
His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile           
65                  70                  75                  80            

tat aac caa gag gag tcc gtg cgc ttc gac agc gac gtg ggg gag tac        288
Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr           
                85                  90                  95                

cgg gcg gtg acg gag ctg ggg cgg cct gat gcc gag tac tgg aac agc        336
Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser           
            100                 105                 110                   

cag aag gac ctc ctg gag cag agg cgg gcc gcg gtg gac acc tac tgc        384
Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys           
        115                 120                 125                       

aga cac aac tac ggg gtt ggt gag agc ttc aca gtg cag cgg ggt ggt        432
Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly Gly           
    130                 135                 140                           

gga ggt tca atc aaa gaa gaa cat gtg atc atc cag gcc gag ttc tat        480
Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr           
145                 150                 155                 160           

ctg aat cct gac caa tca ggc gag ttt atg ttt gac ttt gat ggt gat        528
Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp           
                165                 170                 175               

gag att ttc cat gtg gat atg gca aag aag gag acg gtc tgg cgg ctt        576
Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu           
            180                 185                 190                   

gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa ggt gca ttg gcc        624
Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala           
        195                 200                 205                       

aac ata gct gtg gac aaa gcc aac ctg gaa atc atg aca aag cgc tcc        672
Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser           
    210                 215                 220                           

aac tat act ccg atc acc aat gta cct cca gag gta act gtg ctc aca        720
Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr           
225                 230                 235                 240           

aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc atc tgt ttc ata        768
Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile           
                245                 250                 255               

gac aag ttc acc cca cca gtg gtc aat gtc acg tgg ctt cga aat gga        816
Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly           
            260                 265                 270                   

aaa cct gtc acc aca gga gtg tca gag aca gtc ttc ctg ccc agg gaa        864
Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu           
        275                 280                 285                       

gac cac ctt ttc cgc aag ttc cac tat ctc ccc ttc ctg ccc tca act        912
Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr           
    290                 295                 300                           

gag gac gtt tac gac tgc agg gtg gag cac tgg ggc ttg gat gag cct        960
Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro           
305                 310                 315                 320           

ctt ctc aag cac tgg gag ttt gat gct gga ggc gga gga tct gga ggc       1008
Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly Gly Ser Gly Gly           
                325                 330                 335               

gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga tct gga ggc gga       1056
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
            340                 345                 350                   

gga tct gga ggc gga gga tct gca gct gcg ggt ggc gac aaa act cac       1104
Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His           
        355                 360                 365                       

aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc       1152
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val           
    370                 375                 380                           

ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc       1200
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
385                 390                 395                 400           

cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag       1248
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
                405                 410                 415               

gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag       1296
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
            420                 425                 430                   

aca aag ccg cgg gag gag cag tac gca agc acg tac cgt gtg gtc agc       1344
Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser           
        435                 440                 445                       

gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag       1392
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
    450                 455                 460                           

tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc       1440
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile           
465                 470                 475                 480           

tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc       1488
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
                485                 490                 495               

cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg       1536
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
            500                 505                 510                   

gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat       1584
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
        515                 520                 525                       

ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc       1632
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
    530                 535                 540                           

gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc aga       1680
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
545                 550                 555                 560           

tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cac gag gct ctg       1728
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
                565                 570                 575               

cac aac cac tac acg cag aag tcc ctc tcc ctg tct ccg ggt aaa ggc       1776
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly           
            580                 585                 590                   

gga tca cat cac cat cac cat cac cat cac tag tga                       1812
Gly Ser His His His His His His His His                                   
        595                 600                                           


<210>  206
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            20                  25                  30          


Thr Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln His Lys Phe Glu Cys 
    50                  55                  60                  


His Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
                85                  90                  95      


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Gly Gly 
    130                 135                 140                 


Gly Gly Ser Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr 
145                 150                 155                 160 


Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp 
                165                 170                 175     


Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu 
            180                 185                 190         


Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala 
        195                 200                 205             


Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser 
    210                 215                 220                 


Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr 
225                 230                 235                 240 


Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile 
                245                 250                 255     


Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly 
            260                 265                 270         


Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu 
        275                 280                 285             


Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr 
    290                 295                 300                 


Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro 
305                 310                 315                 320 


Leu Leu Lys His Trp Glu Phe Asp Ala Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Gly Gly Asp Lys Thr His 
        355                 360                 365             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    370                 375                 380                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
385                 390                 395                 400 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                405                 410                 415     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            420                 425                 430         


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
        435                 440                 445             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    450                 455                 460                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
465                 470                 475                 480 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                485                 490                 495     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            500                 505                 510         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        515                 520                 525             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    530                 535                 540                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
545                 550                 555                 560 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                565                 570                 575     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
            580                 585                 590         


Gly Ser His His His His His His His His 
        595                 600         


<210>  207
<211>  1479
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1479)

<400>  207
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt gca cct act tca agt tct aca aag aaa aca cag cta         96
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu           
            20                  25                  30                    

caa ctg gag gca tta ctg ctg gat tta cag atg att ttg aat gga att        144
Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile           
        35                  40                  45                        

aat aat tac aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt        192
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe           
    50                  55                  60                            

tac atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa        240
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu           
65                  70                  75                  80            

gaa gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa        288
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys           
                85                  90                  95                

aac ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata        336
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile           
            100                 105                 110                   

gtt ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct        384
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala           
        115                 120                 125                       

gat gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt        432
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe           
    130                 135                 140                           

tgt caa agc atc atc tca aca ctg act gga ggc gga gga tct ggt ggt        480
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly           
145                 150                 155                 160           

gga ggt tct ggt ggt ggg gga tct gga ggc gga gga tct gca cct act        528
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr           
                165                 170                 175               

tca agt tct aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg        576
Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu           
            180                 185                 190                   

gat tta cag atg att ttg aat gga att aat aat tac aag aat ccc aaa        624
Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys           
        195                 200                 205                       

ctc acc agg atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca        672
Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr           
    210                 215                 220                           

gaa ctg aaa cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag        720
Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu           
225                 230                 235                 240           

gaa gtg cta aat tta gct caa agc aaa aac ttt cac tta aga ccc agg        768
Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg           
                245                 250                 255               

gac tta atc agc aat atc aac gta ata gtt ctg gaa cta aag gga tct        816
Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser           
            260                 265                 270                   

gaa aca aca ttc atg tgt gaa tat gct gat gag aca gca acc att gta        864
Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val           
        275                 280                 285                       

gaa ttt ctg aac aga tgg att acc ttt tgt caa agc atc atc tca aca        912
Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr           
    290                 295                 300                           

ctg act gga ggc gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga        960
Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
305                 310                 315                 320           

tct gga ggc gga gga tct cct aag gtg act gtg tat cct tca aag acc       1008
Ser Gly Gly Gly Gly Ser Pro Lys Val Thr Val Tyr Pro Ser Lys Thr           
                325                 330                 335               

cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg agt ggt ttc       1056
Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe           
            340                 345                 350                   

tat cca ggc agc att gaa gtc agg tgg ttc cgg aac ggc cag gaa gag       1104
Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu           
        355                 360                 365                       

aag gct ggg gtg gtg tcc aca ggc ctg atc cag aat gga gat tgg acc       1152
Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr           
    370                 375                 380                           

ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga gag gtt       1200
Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val           
385                 390                 395                 400           

tac acc tgc caa gtg gag cac cca agt gtg acg agc cct ctc aca gtg       1248
Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val           
                405                 410                 415               

gaa tgg aga gca cgg tct gaa tct gca cag agc aag atg ggt gga ggt       1296
Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly Gly Gly           
            420                 425                 430                   

ggc tca gga ggc ggc ggc agc ggt gga gga ggg agc ctg gag atc gag       1344
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Glu           
        435                 440                 445                       

gcc gcc ttc ctg gag cgg gag aac acc gcc ctg gag acc cgg gtg gcc       1392
Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg Val Ala           
    450                 455                 460                           

gag ctg cgg cag cgg gtg cag cgg ctg cgg aac cgg gtg tcc cag tac       1440
Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser Gln Tyr           
465                 470                 475                 480           

cgg acc cgg tac ggc ccc ctg ggc ggc ggc aag tag tga                   1479
Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys                               
                485                 490                                   


<210>  208
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Pro Lys Val Thr Val Tyr Pro Ser Lys Thr 
                325                 330                 335     


Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe 
            340                 345                 350         


Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu 
        355                 360                 365             


Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr 
    370                 375                 380                 


Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val 
385                 390                 395                 400 


Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val 
                405                 410                 415     


Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ile Glu 
        435                 440                 445             


Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg Val Ala 
    450                 455                 460                 


Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser Gln Tyr 
465                 470                 475                 480 


Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
                485                 490     


<210>  209
<211>  1293
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1293)

<400>  209
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt         48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu           
1               5                   10                  15                

gtc aca aac agt gca cct act tca agt tct aca aag aaa aca cag cta         96
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu           
            20                  25                  30                    

caa ctg gag gca tta ctg ctg gat tta cag atg att ttg aat gga att        144
Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile           
        35                  40                  45                        

aat aat tac aag aat ccc aaa ctc acc agg atg ctc aca gca aag ttt        192
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe           
    50                  55                  60                            

tac atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa        240
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu           
65                  70                  75                  80            

gaa gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa        288
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys           
                85                  90                  95                

aac ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata        336
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile           
            100                 105                 110                   

gtt ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct        384
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala           
        115                 120                 125                       

gat gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt        432
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe           
    130                 135                 140                           

tgt caa agc atc atc tca aca ctg act gga ggc gga gga tct ggt ggt        480
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly           
145                 150                 155                 160           

gga ggt tct ggt ggt ggg gga tct gga ggc gga gga tct gca cct act        528
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr           
                165                 170                 175               

tca agt tct aca aag aaa aca cag cta caa ctg gag gca tta ctg ctg        576
Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu           
            180                 185                 190                   

gat tta cag atg att ttg aat gga att aat aat tac aag aat ccc aaa        624
Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys           
        195                 200                 205                       

ctc acc agg atg ctc aca gca aag ttt tac atg ccc aag aag gcc aca        672
Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr           
    210                 215                 220                           

gaa ctg aaa cat ctt cag tgt cta gaa gaa gaa ctc aaa cct ctg gag        720
Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu           
225                 230                 235                 240           

gaa gtg cta aat tta gct caa agc aaa aac ttt cac tta aga ccc agg        768
Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg           
                245                 250                 255               

gac tta atc agc aat atc aac gta ata gtt ctg gaa cta aag gga tct        816
Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser           
            260                 265                 270                   

gaa aca aca ttc atg tgt gaa tat gct gat gag aca gca acc att gta        864
Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val           
        275                 280                 285                       

gaa ttt ctg aac aga tgg att acc ttt tgt caa agc atc atc tca aca        912
Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr           
    290                 295                 300                           

ctg act gga ggc gga gga tct ggt ggt gga ggt tct ggt ggt ggg gga        960
Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
305                 310                 315                 320           

tct gga ggc gga gga tct cct aag gtg act gtg tat cct tca aag acc       1008
Ser Gly Gly Gly Gly Ser Pro Lys Val Thr Val Tyr Pro Ser Lys Thr           
                325                 330                 335               

cag ccc ctg cag cac cac aac ctc ctg gtc tgc tct gtg agt ggt ttc       1056
Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe           
            340                 345                 350                   

tat cca ggc agc att gaa gtc agg tgg ttc cgg aac ggc cag gaa gag       1104
Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu           
        355                 360                 365                       

aag gct ggg gtg gtg tcc aca ggc ctg atc cag aat gga gat tgg acc       1152
Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr           
    370                 375                 380                           

ttc cag acc ctg gtg atg ctg gaa aca gtt cct cgg agt gga gag gtt       1200
Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val           
385                 390                 395                 400           

tac acc tgc caa gtg gag cac cca agt gtg acg agc cct ctc aca gtg       1248
Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val           
                405                 410                 415               

gaa tgg aga gca cgg tct gaa tct gca cag agc aag atg tag tga           1293
Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met                       
            420                 425                                       


<210>  210
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Pro Lys Val Thr Val Tyr Pro Ser Lys Thr 
                325                 330                 335     


Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe 
            340                 345                 350         


Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu 
        355                 360                 365             


Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr 
    370                 375                 380                 


Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val 
385                 390                 395                 400 


Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val 
                405                 410                 415     


Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys Met 
            420                 425                 


<210>  211
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  212
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  213
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Trp Gln Gly Lys Tyr Lys Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Gln Phe Leu Glu Arg Leu Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Gly Gln Val Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  214
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Leu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  215
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  216
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg His Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Leu Leu Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Ala Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  217
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ala Ala Glu His Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His Tyr Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  218
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  219
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  220
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Leu Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg His Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Arg 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Phe Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  221
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Leu Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  222
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  223
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  224
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  225
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  226
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
1               5                   10                  15      


Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
            20                  25                  30          


Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
        35                  40                  45              


Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
    50                  55                  60                  


Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
65                  70                  75                  80  


Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
                85                  90                  95      


Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
            100                 105                 110         


Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
        115                 120                 125             


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
    130                 135                 140                 


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
145                 150                 155                 160 


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                165                 170                 175     


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
            180                 185                 190         


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 
        195                 200                 205             


Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 
    210                 215                 220                 


Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 
225                 230                 235                 240 


Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 
                245                 250                 255     


Ser Glu Gly Trp His Ile Ser 
            260             


<210>  227
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210>  228
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu 
1               5                   10                  15      


Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro Glu Asp 
            20                  25                  30          


Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr Phe Thr Asn Gly Thr Glu 
        35                  40                  45              


Lys Val Gln Phe Val Val Arg Phe Ile Phe Asn Leu Glu Glu Tyr Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Met Phe Val Ala Leu Thr Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg Leu Asp Leu Leu Glu Arg 
                85                  90                  95      


Ser Arg Gln Ala Val Asp Gly Val Cys Arg His Asn Tyr Arg Leu Gly 
            100                 105                 110         


Ala Pro Phe Thr Val Gly Arg Lys Val Gln Pro Glu Val Thr Val Tyr 
        115                 120                 125             


Pro Glu Arg Thr Pro Leu Leu His Gln His Asn Leu Leu His Cys Ser 
    130                 135                 140                 


Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys Ile Lys Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Arg Ala Gly Val Met Ser Thr Gly Pro Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Val Val Met Leu Glu Met Thr Pro Glu 
            180                 185                 190         


Leu Gly His Val Tyr Thr Cys Leu Val Asp His Ser Ser Leu Leu Ser 
        195                 200                 205             


Pro Val Ser Val Glu Trp Arg Ala Gln Ser Glu Tyr Ser Trp Arg Lys 
    210                 215                 220                 


Met Leu Ser Gly Ile Ala Ala Phe Leu Leu Gly Leu Ile Phe Leu Leu 
225                 230                 235                 240 


Val Gly Ile Val Ile Gln Leu Arg Ala Gln Lys Gly Tyr Val Arg Thr 
                245                 250                 255     


Gln Met Ser Gly Asn Glu Val Ser Arg Ala Val Leu Leu Pro Gln Ser 
            260                 265                 270         


Cys 
    


<210>  229
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Gln Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  230
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  231
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  232
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  233
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  234
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val His Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  235
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Gln Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Arg Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  236
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Ile Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser 
    


<210>  237
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  238
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Met Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  239
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Gln Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  240
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  241
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  242
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Met Met Ser Pro Cys Gly Gly Glu Gly Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Thr Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro 
                245                 250                 


<210>  243
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Lys Leu Pro Leu Phe His Arg Leu Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  244
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Ser His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu 
                85                  90                  95      


Asn Ile Val Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Thr Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Arg Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  245
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Thr Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Ser His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu 
                85                  90                  95      


Asn Ile Val Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Asp Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Thr Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Arg Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  246
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Thr Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  247
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  248
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Thr Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  249
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Thr Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  250
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Ala 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Phe Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Met Phe Ser Lys Phe Ile Ser Phe 
65                  70                  75                  80  


Asp Pro Gln Ser Ala Leu Arg Asn Met Ala Val Gly Lys His Thr Leu 
                85                  90                  95      


Glu Phe Met Met Arg Gln Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Leu Leu 
                245                 250                 255 


<210>  251
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  252
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ser Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
65                  70                  75                  80  


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  253
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  254
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  255
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  256
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  257
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Leu Val Arg Gly Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Arg Leu Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Glu Asp Arg Ala Ser Val Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  258
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Arg Leu Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Glu Asp Arg Ala Ser Val Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  259
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Val Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  260
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  261
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Pro 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Pro Pro Glu Asp Phe Val Leu Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Asp Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Asn Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  262
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  262

Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  263
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen

<400>  263

Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys 
1               5                   10                  15  


<210>  264
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen

<400>  264

Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu 
1               5                   10                  15  


<210>  265
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen


<220>
<221>  MOD_RES
<222>  (14)..(14)

<400>  265

Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu 
1               5                   10                  15  


<210>  266
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  266

Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp 
1               5                   10                  15  


<210>  267
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  267

Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 
1               5                   10                  


<210>  268
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parkinson's associated antigen


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PHOSPHORYLATION

<400>  268

Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
1               5                   10          


<210>  269
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multiple sclerosis-associated antigen 1

<400>  269

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  270
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multiple sclerosis-associated antigen 2

<400>  270

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  271
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  271

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  272
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Cysteine 77 substituted with serine (C77S)

<400>  272

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Ser Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  273
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  273

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  274
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Cysteine 77 substituted with Serine (C77S)

<400>  274

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  275
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  275

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  276
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Cysteine 77 is substituted with serine (C77S)

<400>  276

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Ser Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  277
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The QRRAA amino acid motif appears in the third hypervariable 
       loop of certain DR4 proteins including DRB1 *04:04 DRB1 *04:08 
       and DRB1*04:10

<400>  277

Gln Arg Arg Ala Ala 
1               5   


<210>  278
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  278

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  279
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Motif arranged around binding groove of certain  Class II HLA 
       moleucles

<400>  279

Gln Lys Arg Ala Ala 
1               5   


<210>  280
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Motif arranged around binding groove of certain  Class II HLA 
       moleucles

<400>  280

Gln Gln Arg Ala Ala 
1               5   


<210>  281
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Motif arranged around binding groove of certain  Class II HLA 
       moleucles

<400>  281

Lys Lys Arg Ala Ala 
1               5   


<210>  282
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Motif arranged around binding groove of certain  Class II HLA 
       moleucles

<400>  282

Arg Arg Arg Ala Ala 
1               5   


<210>  283
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Motif arranged around binding groove of certain  Class II HLA 
       moleucles

<400>  283

Arg Asp Arg Ala Ala 
1               5   


