               SEQUENCE LISTING

<110> INSTITUT CURIE

<120> HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER

<130> CV-973/PCT

<150> EP19305310.5
<151> 2019-03-14

<160> 34

<170> BiSSAP 1.3.6

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1B-U2 primer

<400> 1
tgcaaagatg cctgctggtt c                                              21


<210> 2
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1B-L2 primer

<400> 2
tggggttgat gagggagttg ag                                             22


<210> 3
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1D-U1 primer

<400> 3
ccacctagca tgtccccact ga                                             22


<210> 4
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1D-L1 primer

<400> 4
tcccaagcct ctgaggtttc tgt                                            23


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> TBP-U primer

<400> 5
tgcacaggag ccaagagtga a                                              21


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> TBP-L

<400> 6
cacatcacag ctccccacca                                                20


<210> 7
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1A fwd primer

<400> 7
ctcacggctt gcagacct                                                  18


<210> 8
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1A rev primer

<400> 8
gctgggtctc ctttgcac                                                  18


<210> 9
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1B fwd primer

<400> 9
tgcatgaaac ttttatctga tagtcat                                        27


<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1B rev primer

<400> 10
tgttagcaca caaggaatca ca                                             22


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1D fwd primer

<400> 11
attctggggg cctttatcat                                                20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1D rev primer

<400> 12
agatggggag gaccagagac                                                20


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1E fwd primer

<400> 13
cgggttccga gtgagactt                                                 19


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1E rev primer

<400> 14
agggccacag catttcttc                                                 19


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1F fwd primer

<400> 15
aacaggaaca tgaggagacg a                                              21


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR1F rev primer

<400> 16
tgaatttaag aaatccattt tctttgt                                        27


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR2A fwd primer

<400> 17
tgatgtcact tgccatagct g                                              21


<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR2A rev primer

<400> 18
caggtaaatc cagactgcac aa                                             22


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR2C fwd primer

<400> 19
ccgagtccgt ttctcgtcta                                                20


<210> 20
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR2C rev primer

<400> 20
tcgcgggtgt tagctgat                                                  18


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR3A fwd primer

<400> 21
gccaccaaga ctgatgactg                                                20


<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR3A rev primer

<400> 22
tcgggctctt ctcgaagtc                                                 19


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR3B fwd primer

<400> 23
agtgtaatgg ctcccctgtg                                                20


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR3B rev primer

<400> 24
tcctggggat gatgtgtatc t                                              21


<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR4 fwd primer

<400> 25
gaacctgctg gtgatggtg                                                 19


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR4 rev primer

<400> 26
ccgcaaaagc aagagataca                                                20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR5A fwd primer

<400> 27
gtctcaccca tatccgaagc                                                20


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR5A rev primer

<400> 28
ggaccgtgaa caccatctg                                                 19


<210> 29
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR6 fwd primer

<400> 29
agcaggaagg ccctgaag                                                  18


<210> 30
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> HTR6 rev primer

<400> 30
gagatgcagt cgcacacg                                                  18


<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH fwd primer

<400> 31
agccacatcg ctcagacac                                                 19


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH rev primer

<400> 32
gcccaatacg accaaatcc                                                 19


<210> 33
<211> 390
<212> PRT
<213> Homo sapiens


<220> 
<223> 5-HTR1B

<400> 33
Met Glu Glu Pro Gly Ala Gln Cys Ala Pro Pro Pro Pro Ala Gly Ser 
1               5                   10                  15      
Glu Thr Trp Val Pro Gln Ala Asn Leu Ser Ser Ala Pro Ser Gln Asn 
            20                  25                  30          
Cys Ser Ala Lys Asp Tyr Ile Tyr Gln Asp Ser Ile Ser Leu Pro Trp 
        35                  40                  45              
Lys Val Leu Leu Val Met Leu Leu Ala Leu Ile Thr Leu Ala Thr Thr 
    50                  55                  60                  
Leu Ser Asn Ala Phe Val Ile Ala Thr Val Tyr Arg Thr Arg Lys Leu 
65                  70                  75                  80  
His Thr Pro Ala Asn Tyr Leu Ile Ala Ser Leu Ala Val Thr Asp Leu 
                85                  90                  95      
Leu Val Ser Ile Leu Val Met Pro Ile Ser Thr Met Tyr Thr Val Thr 
            100                 105                 110         
Gly Arg Trp Thr Leu Gly Gln Val Val Cys Asp Phe Trp Leu Ser Ser 
        115                 120                 125             
Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His Leu Cys Val Ile Ala 
    130                 135                 140                 
Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Val Glu Tyr Ser Ala Lys 
145                 150                 155                 160 
Arg Thr Pro Lys Arg Ala Ala Val Met Ile Ala Leu Val Trp Val Phe 
                165                 170                 175     
Ser Ile Ser Ile Ser Leu Pro Pro Phe Phe Trp Arg Gln Ala Lys Ala 
            180                 185                 190         
Glu Glu Glu Val Ser Glu Cys Val Val Asn Thr Asp His Ile Leu Tyr 
        195                 200                 205             
Thr Val Tyr Ser Thr Val Gly Ala Phe Tyr Phe Pro Thr Leu Leu Leu 
    210                 215                 220                 
Ile Ala Leu Tyr Gly Arg Ile Tyr Val Glu Ala Arg Ser Arg Ile Leu 
225                 230                 235                 240 
Lys Gln Thr Pro Asn Arg Thr Gly Lys Arg Leu Thr Arg Ala Gln Leu 
                245                 250                 255     
Ile Thr Asp Ser Pro Gly Ser Thr Ser Ser Val Thr Ser Ile Asn Ser 
            260                 265                 270         
Arg Val Pro Asp Val Pro Ser Glu Ser Gly Ser Pro Val Tyr Val Asn 
        275                 280                 285             
Gln Val Lys Val Arg Val Ser Asp Ala Leu Leu Glu Lys Lys Lys Leu 
    290                 295                 300                 
Met Ala Ala Arg Glu Arg Lys Ala Thr Lys Thr Leu Gly Ile Ile Leu 
305                 310                 315                 320 
Gly Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Ile Ile Ser Leu Val 
                325                 330                 335     
Met Pro Ile Cys Lys Asp Ala Cys Trp Phe His Leu Ala Ile Phe Asp 
            340                 345                 350         
Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn Pro Ile Ile 
        355                 360                 365             
Tyr Thr Met Ser Asn Glu Asp Phe Lys Gln Ala Phe His Lys Leu Ile 
    370                 375                 380                 
Arg Phe Lys Cys Thr Ser 
385                 390 

<210> 34
<211> 377
<212> PRT
<213> Homo sapiens


<220> 
<223> 5-HTR1D

<400> 34
Met Ser Pro Leu Asn Gln Ser Ala Glu Gly Leu Pro Gln Glu Ala Ser 
1               5                   10                  15      
Asn Arg Ser Leu Asn Ala Thr Glu Thr Ser Glu Ala Trp Asp Pro Arg 
            20                  25                  30          
Thr Leu Gln Ala Leu Lys Ile Ser Leu Ala Val Val Leu Ser Val Ile 
        35                  40                  45              
Thr Leu Ala Thr Val Leu Ser Asn Ala Phe Val Leu Thr Thr Ile Leu 
    50                  55                  60                  
Leu Thr Arg Lys Leu His Thr Pro Ala Asn Tyr Leu Ile Gly Ser Leu 
65                  70                  75                  80  
Ala Thr Thr Asp Leu Leu Val Ser Ile Leu Val Met Pro Ile Ser Ile 
                85                  90                  95      
Ala Tyr Thr Ile Thr His Thr Trp Asn Phe Gly Gln Ile Leu Cys Asp 
            100                 105                 110         
Ile Trp Leu Ser Ser Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His 
        115                 120                 125             
Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Leu 
    130                 135                 140                 
Glu Tyr Ser Lys Arg Arg Thr Ala Gly His Ala Ala Thr Met Ile Ala 
145                 150                 155                 160 
Ile Val Trp Ala Ile Ser Ile Cys Ile Ser Ile Pro Pro Leu Phe Trp 
                165                 170                 175     
Arg Gln Ala Lys Ala Gln Glu Glu Met Ser Asp Cys Leu Val Asn Thr 
            180                 185                 190         
Ser Gln Ile Ser Tyr Thr Ile Tyr Ser Thr Cys Gly Ala Phe Tyr Ile 
        195                 200                 205             
Pro Ser Val Leu Leu Ile Ile Leu Tyr Gly Arg Ile Tyr Arg Ala Ala 
    210                 215                 220                 
Arg Asn Arg Ile Leu Asn Pro Pro Ser Leu Tyr Gly Lys Arg Phe Thr 
225                 230                 235                 240 
Thr Ala His Leu Ile Thr Gly Ser Ala Gly Ser Ser Leu Cys Ser Leu 
                245                 250                 255     
Asn Ser Ser Leu His Glu Gly His Ser His Ser Ala Gly Ser Pro Leu 
            260                 265                 270         
Phe Phe Asn His Val Lys Ile Lys Leu Ala Asp Ser Ala Leu Glu Arg 
        275                 280                 285             
Lys Arg Ile Ser Ala Ala Arg Glu Arg Lys Ala Thr Lys Ile Leu Gly 
    290                 295                 300                 
Ile Ile Leu Gly Ala Phe Ile Ile Cys Trp Leu Pro Phe Phe Val Val 
305                 310                 315                 320 
Ser Leu Val Leu Pro Ile Cys Arg Asp Ser Cys Trp Ile His Pro Ala 
                325                 330                 335     
Leu Phe Asp Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn 
            340                 345                 350         
Pro Ile Ile Tyr Thr Val Phe Asn Glu Glu Phe Arg Gln Ala Phe Gln 
        355                 360                 365             
Lys Ile Val Pro Phe Arg Lys Ala Ser 
    370                 375         

