                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  METHOD

<130>  P117262PCT

<150>  GB 1903237.4
<151>  2019-03-08

<150>  GB 1914216.5
<151>  2019-10-02

<150>  GB 1916077.9
<151>  2019-11-05

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region (VH) complementarity determining 
       region (CDR) CDR1

<400>  1

Gly Tyr Ala Phe Ser Ser Ser 
1               5           


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR2

<400>  2

Tyr Pro Gly Asp Glu Asp 
1               5       


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR3

<400>  3

Ser Leu Leu Tyr Gly Asp Tyr Leu Asp Tyr 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region (VL) CDR, CDR1

<400>  4

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR2

<400>  5

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR3

<400>  6

Gln Gln Trp Asn Ile Asn Pro Leu Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain sequence

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Glu Asp Thr Asn Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Leu Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain sequence

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Phe Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ile Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  9
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  9

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR1

<400>  10

Asn Phe Ala Met Ala 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR2

<400>  11

Ser Ile Ser Thr Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR3

<400>  12

Gln Arg Asn Tyr Tyr Asp Gly Ser Tyr Asp Tyr Glu Gly Tyr Thr Met 
1               5                   10                  15      


Asp Ala 
        


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR1

<400>  13

Arg Ser Ser Gln Asp Ile Gly Asn Tyr Leu Thr 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR2

<400>  14

Gly Ala Ile Lys Leu Glu Asp 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR3

<400>  15

Leu Gln Ser Ile Gln Tyr Pro 
1               5           


<210>  16
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Pro Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Asn Tyr Tyr Asp Gly Ser Tyr Asp Tyr Glu Gly Tyr 
            100                 105                 110         


Thr Met Asp Ala Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Lys Val Gly Arg Ser Pro Arg Arg Met Ile 
        35                  40                  45              


Tyr Gly Ala Ile Lys Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Gln Cys Leu Gln Ser Ile Gln Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine kinase domain of Fyn

<400>  18

Leu Gln Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys 
            20                  25                  30          


Pro Gly Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met 
        35                  40                  45              


Lys Lys Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
    50                  55                  60                  


Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu 
65                  70                  75                  80  


Leu Asp Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn 
                85                  90                  95      


Leu Val Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu 
            100                 105                 110         


Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val 
        115                 120                 125             


Gly Asn Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Arg Ala Leu Tyr Gly Arg Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys 
            180                 185                 190         


Gly Arg Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln 
        195                 200                 205             


Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser 
    210                 215                 220                 


Leu His Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe 
                245                 250                 


<210>  19
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine kinase domain of Src

<400>  19

Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Thr Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys 
            20                  25                  30          


Pro Gly Thr Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met 
        35                  40                  45              


Lys Lys Leu Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
    50                  55                  60                  


Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu 
65                  70                  75                  80  


Leu Asp Phe Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln 
                85                  90                  95      


Leu Val Asp Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu 
            100                 105                 110         


Arg Met Asn Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Gly Glu Asn Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys 
            180                 185                 190         


Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln 
        195                 200                 205             


Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser 
    210                 215                 220                 


Leu His Asp Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe 
                245                 250                 


<210>  20
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine kinase domain of Lck

<400>  20

Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val Lys Ser Leu Lys 
            20                  25                  30          


Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala Asn Leu Met 
        35                  40                  45              


Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    50                  55                  60                  


Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu 
65                  70                  75                  80  


Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Thr Ile Asn Lys 
                85                  90                  95      


Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu 
            100                 105                 110         


Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile Val Thr His 
            180                 185                 190         


Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val Ile Gln Asn 
        195                 200                 205             


Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys Pro Glu Glu 
    210                 215                 220                 


Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg Pro Glu Asp Arg 
225                 230                 235                 240 


Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp Phe Phe 
                245                 250                 


<210>  21
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine kinase domain of Lck_Y505F

<400>  21

Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val Arg Ser Leu Lys 
            20                  25                  30          


Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala Asn Leu Met 
        35                  40                  45              


Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    50                  55                  60                  


Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu 
65                  70                  75                  80  


Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Thr Ile Asn Lys 
                85                  90                  95      


Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu 
            100                 105                 110         


Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile Val Thr His 
            180                 185                 190         


Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val Ile Gln Asn 
        195                 200                 205             


Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys Pro Glu Glu 
    210                 215                 220                 


Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg Pro Glu Asp Arg 
225                 230                 235                 240 


Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp Phe Phe 
                245                 250                 


<210>  22
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic tail of CD4

<400>  22

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic tail of CD8

<400>  23

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-1 SH2 complete domain

<400>  24

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr 
    210                 


<210>  25
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-1 SH2 1

<400>  25

Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr Leu Leu Lys 
1               5                   10                  15      


Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser Arg Lys Asn 
            20                  25                  30          


Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln Val Thr His 
        35                  40                  45              


Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr Gln Gln Gln 
65                  70                  75                  80  


Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu Lys Tyr Pro 
                85                  90                  95      


Leu 
    


<210>  26
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-1 SH2 2

<400>  26

Trp Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln 
1               5                   10                  15      


Ala Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly 
        35                  40                  45              


Pro Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly 
    50                  55                  60                  


Gly Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp 
65                  70                  75                  80  


Leu Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala 
                85                  90                  95      


Phe Val Tyr Leu Arg Gln Pro Tyr 
            100                 


<210>  27
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-2 first SH2 domain

<400>  27

Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala Glu Asn Leu Leu Leu 
1               5                   10                  15      


Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg Pro Ser Lys Ser Asn 
            20                  25                  30          


Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn Gly Ala Val Thr His 
        35                  40                  45              


Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr Tyr Met Glu His His 
65                  70                  75                  80  


Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile Glu Leu Lys Tyr Pro 
                85                  90                  95      


Leu 
    


<210>  28
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-2 second SH2 domain

<400>  28

Trp Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr 
1               5                   10                  15      


Glu Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu 
        35                  40                  45              


Ser Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln 
    50                  55                  60                  


Glu Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr 
65                  70                  75                  80  


Asp Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly 
                85                  90                  95      


Thr Val Leu Gln Leu Lys Gln Pro Leu 
            100                 105 


<210>  29
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-2 both SH2 domains

<400>  29

Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala Glu Asn Leu Leu Leu 
1               5                   10                  15      


Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg Pro Ser Lys Ser Asn 
            20                  25                  30          


Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn Gly Ala Val Thr His 
        35                  40                  45              


Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr Tyr Met Glu His His 
65                  70                  75                  80  


Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile Glu Leu Lys Tyr Pro 
                85                  90                  95      


Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp Phe His Gly His Leu 
            100                 105                 110         


Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu Lys Gly Lys His Gly 
        115                 120                 125             


Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro Gly Asp Phe Val Leu 
    130                 135                 140                 


Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser Asn Asp Gly Lys Ser 
145                 150                 155                 160 


Lys Val Thr His Val Met Ile Arg Cys Gln Glu Leu Lys Tyr Asp Val 
                165                 170                 175     


Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp Leu Val Glu His Tyr 
            180                 185                 190         


Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr Val Leu Gln Leu Lys 
        195                 200                 205             


Gln Pro Leu 
    210     


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Light Kappa Chain

<400>  30

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Hinge

<400>  31

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Lys 
1               5                   10                  15      


Asp Pro Lys 
            


<210>  32
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CH1

<400>  32

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val 
    


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain from human IL2R common gamma chain

<400>  33

Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu 
            20      


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain from human IL-2R beta

<400>  34

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  35

<400>  35
000

<210>  36
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain from human IL-7R alpha

<400>  36

Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210>  37
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain from Human GF-CSFR alpha

<400>  37

Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
1               5                   10                  15      


Val Cys Gly Ile Val Leu Gly Phe Leu Phe 
            20                  25      


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain from Human GM-CSFR common beta chain

<400>  38

Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala 
1               5                   10                  15      


Leu 
    


<210>  39
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain from human IL2R common gamma chain

<400>  39

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  40
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain from human IL-2R beta

<400>  40

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  41
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain from human IL-7R alpha

<400>  41

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Glu Gln 
        195     


<210>  42
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain Derived from Human GM-CSFR alpha

<400>  42

Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile 
1               5                   10                  15      


Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp 
            20                  25                  30          


Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu 
        35                  40                  45              


Thr Val Lys Glu Ile Thr 
    50                  


<210>  43
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain from GM-CSFR common beta chain

<400>  43

Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature protein of wild-type TGFbeta2

<400>  44

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  45
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFbeta monomer sequence

<400>  45

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Arg Ala Ser Lys Ser Pro Ser Cys Val Ser Gln Asp Leu Glu Pro Leu 
        355                 360                 365             


Thr Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser 
    370                 375                 380                 


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
385                 390                 


<210>  46
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dominant-negative TGFbeta RII (dnTGFbeta RII)

<400>  46

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
145                 150                 155                 160 


Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser 
                165                 170                 175     


Ser 
    


<210>  47
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MH2 domain of SMAD2

<400>  47

Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu Thr 
1               5                   10                  15      


Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp Pro 
            20                  25                  30          


Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg 
        35                  40                  45              


Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val Arg 
    50                  55                  60                  


Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp Ser 
65                  70                  75                  80  


Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp His 
                85                  90                  95      


Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile Phe 
            100                 105                 110         


Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln Gly 
        115                 120                 125             


Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met Ser 
    130                 135                 140                 


Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr Ser 
145                 150                 155                 160 


Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp Leu 
                165                 170                 175     


Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser Ser 
            180                 185                 190         


Met Ser 
        


<210>  48
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MH2 domain of SMAD3

<400>  48

Trp Cys Ser Ile Ser Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu Thr 
1               5                   10                  15      


Phe His Ala Ser Gln Pro Ser Met Thr Val Asp Gly Phe Thr Asp Pro 
            20                  25                  30          


Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg 
        35                  40                  45              


Asn Ala Ala Val Glu Leu Thr Arg Arg His Ile Gly Arg Gly Val Arg 
    50                  55                  60                  


Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp Ser 
65                  70                  75                  80  


Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp His 
                85                  90                  95      


Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile Phe 
            100                 105                 110         


Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln Gly 
        115                 120                 125             


Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met Ser 
    130                 135                 140                 


Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr Ser 
145                 150                 155                 160 


Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp Leu 
                165                 170                 175     


Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Ile Arg Cys Ser Ser 
            180                 185                 190         


Val Ser 
        


<210>  49
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MH2 domain of SMAD4

<400>  49

Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly Glu Thr 
1               5                   10                  15      


Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly Tyr Val 
            20                  25                  30          


Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser Asn Val 
        35                  40                  45              


His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly Lys Gly 
    50                  55                  60                  


Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg Cys Leu 
65                  70                  75                  80  


Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg Glu Ala 
                85                  90                  95      


Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser Ala Tyr 
            100                 105                 110         


Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln Gln Gln 
        115                 120                 125             


Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala Val Ala 
    130                 135                 140                 


Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro Ala Ile 
145                 150                 155                 160 


Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg Arg Leu 
                165                 170                 175     


Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp Tyr Pro 
            180                 185                 190         


Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His Leu His 
        195                 200                 205             


Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro Ile Ala 
    210                 215                 220                 


Asp Pro Gln Pro Leu Asp 
225                 230 


<210>  50
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric dnSMAD comprising a dnSMAD2 polypeptide and a dnSMAD3 
       polypeptide

<400>  50

Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu Thr 
1               5                   10                  15      


Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp Pro 
            20                  25                  30          


Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg 
        35                  40                  45              


Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val Arg 
    50                  55                  60                  


Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp Ser 
65                  70                  75                  80  


Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp His 
                85                  90                  95      


Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile Phe 
            100                 105                 110         


Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln Gly 
        115                 120                 125             


Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met Ser 
    130                 135                 140                 


Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr Ser 
145                 150                 155                 160 


Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp Leu 
                165                 170                 175     


Asp Lys Val Leu Thr Gln Met Leu Glu Tyr Ser Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Ser Leu Glu Trp Cys Ser Ile Ser Tyr Tyr Glu Leu Asn Gln 
        195                 200                 205             


Arg Val Gly Glu Thr Phe His Ala Ser Gln Pro Ser Met Thr Val Asp 
    210                 215                 220                 


Gly Phe Thr Asp Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu 
225                 230                 235                 240 


Ser Asn Val Asn Arg Asn Ala Ala Val Glu Leu Thr Arg Arg His Ile 
                245                 250                 255     


Gly Arg Gly Val Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu 
            260                 265                 270         


Cys Leu Ser Asp Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln 
        275                 280                 285             


Arg Tyr Gly Trp His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys 
    290                 295                 300                 


Asn Leu Lys Ile Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln 
305                 310                 315                 320 


Ser Val Asn Gln Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys 
                325                 330                 335     


Thr Ile Arg Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg 
            340                 345                 350         


Gln Thr Val Thr Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly 
        355                 360                 365             


Pro Leu Gln Trp Leu Asp Lys Val Leu Thr Gln Met 
    370                 375                 380 


<210>  51
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric TNF receptor HVEM-41BB

<400>  51

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Arg Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Ile Ile Ser Phe Phe Leu 
        195                 200                 205             


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
    210                 215                 220                 


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
225                 230                 235                 240 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                245                 250                 255     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            260                 265                 270     


<210>  52
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric TNF receptor CD27-41BB

<400>  52

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu 
        195                 200                 205             


Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu 
            260 


<210>  53
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric TNF receptor RANK-41BB

<400>  53

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys 
225                 230                 235                 240 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                245                 250                 255     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            260                 265                 270         


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280     


<210>  54
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric TNF receptor Fn14-41BB

<400>  54

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
                85                  90                  95      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
            100                 105                 110         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        115                 120                 125             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    130                 135                 140                 


Gly Gly Cys Glu Leu 
145                 


<210>  55
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF receptor ligand CD40L

<400>  55

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  56
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF receptor ligand OX40L

<400>  56

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  57
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF receptor ligand 41BBL

<400>  57

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic amino acid furin target sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Arg or Lys

<400>  58

Arg Xaa Xaa Arg 
1               


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Tobacco Etch Virus (TEV) cleavage site

<400>  59

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM (immunoreceptor tyrosine-based activation motif)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Leu or Ile

<400>  60

Tyr Xaa Xaa Xaa 
1               


<210>  61
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  frame-slip motif (FSM)

<400>  61
uuuuuuu                                                                  7


<210>  62
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  frame-slip motif (FSM) comprising a stop codon

<400>  62
uuuuuuuga                                                                9


<210>  63
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FSM comprising a stop codon

<400>  63
uuuuuuuag                                                                9


<210>  64
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FSM comprising a stop codon

<400>  64
uuuuuuuaa                                                                9


<210>  65
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  translational readthrough motif (TRM) comprising a stop codon

<400>  65
ugacuag                                                                  7


<210>  66
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRM comprising a stop codon

<400>  66
uagcuag                                                                  7


<210>  67
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRM comprising a stop codon

<400>  67
uaacuag                                                                  7


<210>  68
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRM comprising a stop codon

<400>  68
ugacaauua                                                                9


<210>  69
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRM comprising a stop codon

<400>  69
uagcaauua                                                                9


<210>  70
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRM comprising a stop codon

<400>  70
uaacaauua                                                                9


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR1

<400>  71

Ser Tyr Asn Ile His 
1               5   


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR2

<400>  72

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR, CDR3

<400>  73

Arg Ser Asp Asp Tyr Ser Trp Phe Ala Tyr 
1               5                   10  


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR1

<400>  74

Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR2

<400>  75

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR, CDR3

<400>  76

Gln Gln Tyr Ser Gly Tyr Pro Ile Thr 
1               5                   


<210>  77
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised KM666 VH sequence

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ala Ser Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Arg Ser Asp Asp Tyr Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  78
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised KM666 VL sequence

<400>  78

Glu Asn Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Val Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  79
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sort/suicide gene RQR8

<400>  79

Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro 
            20                  25                  30          


Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    50                  55                  60                  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
65                  70                  75                  80  


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  95      


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            100                 105                 110         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
        115                 120                 125             


Cys Lys Cys Pro Arg Pro Val Val 
    130                 135     


<210>  80
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  suicide gene Rapcasp9

<400>  80

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Tyr Ser Gly Gly Gly Ser Leu Glu Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    130                 135                 140                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
145                 150                 155                 160 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                165                 170                 175     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            180                 185                 190         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        195                 200                 205             


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met 
                245                 250                 255     


Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg 
            260                 265                 270         


Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys 
        275                 280                 285             


Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly 
    290                 295                 300                 


Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln 
305                 310                 315                 320 


Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His 
                325                 330                 335     


Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr 
            340                 345                 350         


Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly 
        355                 360                 365             


Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln 
    370                 375                 380                 


Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr 
385                 390                 395                 400 


Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr 
                405                 410                 415     


Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser 
            420                 425                 430         


Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro 
        435                 440                 445             


Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu 
    450                 455                 460                 


Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln 
465                 470                 475                 480 


Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr 
                485                 490                 495     


Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe 
            500                 505                 510         


Lys Thr Ser Ala Ser 
        515         


<210>  81
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a flexi-IL-12 sequence

<400>  81

Met Trp Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
1               5                   10                  15      


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
            20                  25                  30          


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
        35                  40                  45              


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
    50                  55                  60                  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
65                  70                  75                  80  


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
                85                  90                  95      


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
            100                 105                 110         


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
        115                 120                 125             


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
    130                 135                 140                 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
145                 150                 155                 160 


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
                165                 170                 175     


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
            180                 185                 190         


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
        195                 200                 205             


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
    210                 215                 220                 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
225                 230                 235                 240 


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
                245                 250                 255     


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
            260                 265                 270         


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
        275                 280                 285             


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
    290                 295                 300                 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Arg Asn Leu Pro Leu Ala Thr Pro Asp Pro Gly Met Phe 
                325                 330                 335     


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
            340                 345                 350         


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
        355                 360                 365             


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
    370                 375                 380                 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
385                 390                 395                 400 


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
                405                 410                 415     


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Ser 
            420                 425                 430         


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
        435                 440                 445             


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
    450                 455                 460                 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
465                 470                 475                 480 


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
                485                 490                 495     


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
            500                 505                 510         


Val Met Ser Tyr Leu Asn Ala Ser 
        515                 520 


