                               SEQUENCE LISTING

<110> SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
 
<120> NANOMOLAR PEPTIDES AND DERIVATIVES TO DIFFERENTIALLY MODULATE 
      EPHRIN RECEPTORS

<130> 42256-745.601

<140> PCT/US2020/022765
<141> 2020-03-13

<150> 62/818,647
<151> 2019-03-14

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(2)
<223> This region may encompass "Y-S" or "W-L"

<220>
<221> MISC_FEATURE
<222> (10)..(14)
<223> This region may encompass "M-M-S" or "Mam" or "Yam" or 
      "Y-K" or "Y-S-K" or "Y-G-S-K" or "Y-G-S-G-K" or "Y-R" 
      or "Y-S" 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 1
Xaa Xaa Ala Tyr Pro Asp Ser Val Pro Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Tyr Gly Ser Lys 
1               


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Tyr Gly Ser Gly Lys 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Ser Gly Ser Lys 
1               5   


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met 
1               5                   10  


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Tyr Ser Ala Tyr 
1               


<210> 7
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A1 sequence

<400> 7
Phe Thr Pro Phe 
1               


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ser Ala Tyr Pro Asp Ser Val Pro Phe Arg Pro 
1               5                   10      


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala His His His His His His 
1               5           


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Met Ala Ser Gln Gly Pro Gly 
1               5           


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met Met Ser 
1               5                   10          


<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met Met Ser Gly Ser Gly Ser 
1               5                   10                  15      


Lys 
    


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met Met Ser Gly Ser Gly Ser 
1               5                   10                  15      


Lys 
    


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met Met Ser Lys 
1               5                   10              


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met 
1               5                   10  


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Trp Leu Ala Tyr Pro Gly Ala Val Ser Tyr Arg 
1               5                   10          


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Trp Leu Ala Tyr Pro Asp Ser Val Pro Met 
1               5                   10  


<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 18
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Met 
1               5                   10      


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 19
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr 
1               5                   10      


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 20
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Lys 
1               5                   10          


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 21
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Ser Lys 
1               5                   10              


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 22
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Ser Lys 
1               5                   10              


<210> 23
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 23
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Gly Ser Lys 
1               5                   10                  


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 24
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Gly Ser Gly Lys 
1               5                   10                  15  


<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 25
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg 
1               5                   10          


<210> 26
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 26
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  


<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 27
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  


<210> 28
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 28
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Ser Pro Lys 
1               5                   10                  


<210> 29
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 29
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  


<210> 30
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 30
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 31
Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  


<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Lys Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  15  


<210> 33
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Carbamidomethyl-cysteine

<400> 33
Cys Gly Ala Trp Leu Ala Tyr Pro Asp Ser Val Pro Tyr Arg Pro Lys 
1               5                   10                  15      


<210> 34
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A1 sequence

<400> 34
Phe Thr Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu 
1               5                   10          


<210> 35
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A2 sequence

<400> 35
Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Arg Pro 
1               5                   10          


<210> 36
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A3 sequence

<400> 36
Tyr Ser Ala Phe Ser Leu Gly Tyr Glu Phe His Ala 
1               5                   10          


<210> 37
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A4 sequence

<400> 37
Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro 
1               5                   10          


<210> 38
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Ephrin-A5 sequence

<400> 38
Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Arg Pro 
1               5                   10          


