                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  A Loss of Function Rodent Model of Solute Carrier 39 Member 5

<130>  36843PCT (10535WO01)

<150>  62/818,872
<151>  2019-03-15

<150>  62/976,437
<151>  2020-02-14

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1980
<212>  DNA
<213>  Homo sapiens

<400>  1
gcctgccccc ccagctggaa ccaagaaggt tgtgtccccc ttcctctggg tgtccttgtc       60

tcctgctatc agggcttccc ctttcttggt catcgatccc tagagctctg gctctttctc      120

ttcttgggga actgcttaac gtctacagca aggcctaata ggggacctga gggcacagtc      180

ctcaggatgt ttcggggaga ataggagcca gaacctgagc ccctaagcta ttcccctcac      240

caatgatggg gtccccagtg agtcatctgc tggccggctt ctgtgtgtgg gtcgtcttgg      300

gctgggtagg gggctcagtc cccaacctgg gccctgctga gcaggagcag aaccattacc      360

tggcccagct gtttggcctg tacggcgaga atgggacgct gactgcaggg ggcttggcgc      420

ggcttctcca cagcctgggg ctaggccgag ttcaggggct tcgcctggga cagcatgggc      480

ctctgactgg acgggctgca tccccagctg cagacaattc cacacacagg ccacagaacc      540

ctgagctgag tgtggatgtc tgggcaggga tgcctctggg tccctcaggg tggggtgacc      600

tggaagagtc aaaggcccct cacctacccc gtgggccagc cccctcgggc ctggacctcc      660

ttcacaggct tctgttgctg gaccactcat tggctgacca cctgaatgag gattgtctga      720

acggctccca gctgctggtc aattttggct tgagccccgc tgctcctctg acccctcgtc      780

agtttgctct gctgtgccca gccctgcttt atcagatcga cagccgcgtc tgcatcggcg      840

ctccggcccc tgcaccccca ggggatctac tatctgccct gcttcagagt gccctggcag      900

tcctgttgct cagcctccct tctcccctat ccctgctgct gctgcggctc ctgggacctc      960

gtctactacg gcccttgctg ggcttcctgg gggccctggc ggtgggcact ctttgtgggg     1020

atgcactgct acatctgcta ccgcatgcac aagaagggcg gcacgcagga cctggcggac     1080

taccagagaa ggacctgggc ccggggctgt cagtgctcgg aggcctcttc ctgctctttg     1140

tgctggagaa catgctgggg cttttgcggc accgagggct caggccaaga tgctgcaggc     1200

gaaaacgaag gaatctcgaa acacgcaact tggatccgga gaatggcagt gggatggccc     1260

ttcagcccct acaggcagct ccagagccag gggctcaggg ccagagggag aagaacagcc     1320

agcacccacc agctctggcc cctcctgggc accaaggcca cagtcatggg caccagggtg     1380

gcactgatat cacgtggatg gtcctcctgg gagatggtct acacaacctc actgatgggc     1440

tggccatagg tgctgccttc tctgatggct tctccagcgg cctcagtacc accttagcgg     1500

tcttctgcca tgagctgccc cacgaactgg gtgactttgc catgctgctc cagtcagggc     1560

tgtcctttcg gcggctgctg ctgctgagcc tcgtgtctgg agccctggga ttggggggtg     1620

cagtcctggg ggtggggctc agcctgggcc ctgtccccct cactccctgg gtgtttgggg     1680

tcactgctgg ggtcttcctc tatgtggccc ttgtggacat gctaccagcc ctgcttcgtc     1740

ctccggagcc cctgcctacg ccccatgtgc tcctgcaggg gctggggctg ctgctggggg     1800

gcggcctcat gcttgccata accctgctgg aggagcggct actgcccgtg accactgagg     1860

gctgatgggg ccagtggaaa ggggtcgggt tgcccttcct tccccccaac cacaggaatg     1920

gaggcgggac acagggccag taggagcaat aggattttaa taaacagaac ccatcccaaa     1980


<210>  2
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Gly Ser Pro Val Ser His Leu Leu Ala Gly Phe Cys Val Trp 
1               5                   10                  15      


Val Val Leu Gly Trp Val Gly Gly Ser Val Pro Asn Leu Gly Pro Ala 
            20                  25                  30          


Glu Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly 
        35                  40                  45              


Glu Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser 
    50                  55                  60                  


Leu Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly Gln His Gly Pro 
65                  70                  75                  80  


Leu Thr Gly Arg Ala Ala Ser Pro Ala Ala Asp Asn Ser Thr His Arg 
                85                  90                  95      


Pro Gln Asn Pro Glu Leu Ser Val Asp Val Trp Ala Gly Met Pro Leu 
            100                 105                 110         


Gly Pro Ser Gly Trp Gly Asp Leu Glu Glu Ser Lys Ala Pro His Leu 
        115                 120                 125             


Pro Arg Gly Pro Ala Pro Ser Gly Leu Asp Leu Leu His Arg Leu Leu 
    130                 135                 140                 


Leu Leu Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn 
145                 150                 155                 160 


Gly Ser Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Ala Ala Pro Leu 
                165                 170                 175     


Thr Pro Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile 
            180                 185                 190         


Asp Ser Arg Val Cys Ile Gly Ala Pro Ala Pro Ala Pro Pro Gly Asp 
        195                 200                 205             


Leu Leu Ser Ala Leu Leu Gln Ser Ala Leu Ala Val Leu Leu Leu Ser 
    210                 215                 220                 


Leu Pro Ser Pro Leu Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg 
225                 230                 235                 240 


Leu Leu Arg Pro Leu Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr 
                245                 250                 255     


Leu Cys Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Glu Gly 
            260                 265                 270         


Arg His Ala Gly Pro Gly Gly Leu Pro Glu Lys Asp Leu Gly Pro Gly 
        275                 280                 285             


Leu Ser Val Leu Gly Gly Leu Phe Leu Leu Phe Val Leu Glu Asn Met 
    290                 295                 300                 


Leu Gly Leu Leu Arg His Arg Gly Leu Arg Pro Arg Cys Cys Arg Arg 
305                 310                 315                 320 


Lys Arg Arg Asn Leu Glu Thr Arg Asn Leu Asp Pro Glu Asn Gly Ser 
                325                 330                 335     


Gly Met Ala Leu Gln Pro Leu Gln Ala Ala Pro Glu Pro Gly Ala Gln 
            340                 345                 350         


Gly Gln Arg Glu Lys Asn Ser Gln His Pro Pro Ala Leu Ala Pro Pro 
        355                 360                 365             


Gly His Gln Gly His Ser His Gly His Gln Gly Gly Thr Asp Ile Thr 
    370                 375                 380                 


Trp Met Val Leu Leu Gly Asp Gly Leu His Asn Leu Thr Asp Gly Leu 
385                 390                 395                 400 


Ala Ile Gly Ala Ala Phe Ser Asp Gly Phe Ser Ser Gly Leu Ser Thr 
                405                 410                 415     


Thr Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe 
            420                 425                 430         


Ala Met Leu Leu Gln Ser Gly Leu Ser Phe Arg Arg Leu Leu Leu Leu 
        435                 440                 445             


Ser Leu Val Ser Gly Ala Leu Gly Leu Gly Gly Ala Val Leu Gly Val 
    450                 455                 460                 


Gly Leu Ser Leu Gly Pro Val Pro Leu Thr Pro Trp Val Phe Gly Val 
465                 470                 475                 480 


Thr Ala Gly Val Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Ala 
                485                 490                 495     


Leu Leu Arg Pro Pro Glu Pro Leu Pro Thr Pro His Val Leu Leu Gln 
            500                 505                 510         


Gly Leu Gly Leu Leu Leu Gly Gly Gly Leu Met Leu Ala Ile Thr Leu 
        515                 520                 525             


Leu Glu Glu Arg Leu Leu Pro Val Thr Thr Glu Gly 
    530                 535                 540 


<210>  3
<211>  1944
<212>  DNA
<213>  Mus musculus

<400>  3
aaggctgggt cccccttcct cttggtgtct tttgtgtctc ctgtcctgcc gtcagccctc       60

cttgtgacgt ggcttccact gcatctgaag gctgagctcc ttccctcgga tctcctaagg      120

tccacagtga ggccttccag ggacctgagg gtacagtcct caggatgtct caaaggaaat      180

agaagtcaga aacagagcct ctaaccatag ccctagtgat ggggccccca gtacatcatc      240

tgctgactgg cctatgtgtg ggggtggcct tgggctgggt aggaggctcc gtcccaaacc      300

tgggcccagc tgaacaggaa cagaaccact acctggccca gttgtttggt ctatatggag      360

agaacgggac actgactgca gggggcctgg cgcggcttct ccacagccta ggactaggcc      420

gagtccaggg gctccgtctg ggacaccatg agcctccaac tgggcgggct gcacccacaa      480

gtggagacaa tttcacacac aggctgcaag agccggagct gagtgtggac atctgggcag      540

gaatgcctct gggcccttca ggttggggtg accaggagga atcaaaggct cctgacctgc      600

acgggtcagg gccctcgagc ctagacctct tccagaggct tctgctgttg gaccattcgt      660

tggctgacca tctgaatgag gattgtctga atggctccca gctgctggtc aattttggac      720

tgagccctgt tgctcctctg acccctcgtc agttcgctct gctgtgccca gccctgcttt      780

atcagattga cagccgtgtt tgcatcaaaa ccccagctcc agcacctccg ggggatgtac      840

tgtctgccct gcttcacagt ggcctggcag tcctgttcct cagcctccct gctcccctct      900

ctctgctgtt gctgcggctc ctgggacctc gtctgttgcg gccagtgctg ggcttcctgg      960

gggccctggc cgtgggtact ctctgtgggg atgccctgct acacctgctc ccacatgcgc     1020

aaggagggcg gcacacagga cctagtgagc aatcagagga ggacctgggt ccgggactgt     1080

cggtgcttgg tggcctcttc ctgctcttca tgctagagaa cacactagga cttgtgcggc     1140

acagagggct caggccaaga tgctgcagga acaaaaggga tcttggagaa ccaaaccctg     1200

acccagagga tggcagtggg atggtccttc gacccctaca ggcagcttca gaaccagagg     1260

ttcagggcca gagggagaac agacagtcct caccatctct agcccctcct gggcaccaag     1320

gccacagcca tgagcaccgg ggtggcagta tcgcatggat ggtcctcctg ggagattgcc     1380

tgcacaacct caccgacggg ctggcattag gtgctgcttt ctcagacggc ttctccagtg     1440

gcctcagcac taccctagca gtcttctgcc acgagctgcc ccacgaactg ggtgactttg     1500

ccatgctgct tcaggaaggg ttatcctttc ggaagctgct gctgctgagc ctcgtttctg     1560

gagccctggg actggggggt gcagccctgg gggtggggct cagcttgggc cctgtgcccc     1620

tcaccccctg ggtgtttggg accacggctg gggttttcct ctatgtggcc ctagtggata     1680

tgctgccaac cctgcttcgt cctcctgagc ccctgcctgt gttccacgtg cttctgcagg     1740

ggctggggct gctactgggg ggcagcctca tgtttaccat agccctattg gaggagcagc     1800

tagtgcccac ggttcctgac ggctgatgtg ggccagtggc agaggatcca ggttgccctt     1860

ccttcccccc accacaggaa tggaggcggg acacagggcc agtaggagca ataggatttt     1920

aataaacaga acccatccca aaaa                                            1944


<210>  4
<211>  535
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Pro Pro Val His His Leu Leu Thr Gly Leu Cys Val Gly Val 
1               5                   10                  15      


Ala Leu Gly Trp Val Gly Gly Ser Val Pro Asn Leu Gly Pro Ala Glu 
            20                  25                  30          


Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly Glu 
        35                  40                  45              


Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser Leu 
    50                  55                  60                  


Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly His His Glu Pro Pro 
65                  70                  75                  80  


Thr Gly Arg Ala Ala Pro Thr Ser Gly Asp Asn Phe Thr His Arg Leu 
                85                  90                  95      


Gln Glu Pro Glu Leu Ser Val Asp Ile Trp Ala Gly Met Pro Leu Gly 
            100                 105                 110         


Pro Ser Gly Trp Gly Asp Gln Glu Glu Ser Lys Ala Pro Asp Leu His 
        115                 120                 125             


Gly Ser Gly Pro Ser Ser Leu Asp Leu Phe Gln Arg Leu Leu Leu Leu 
    130                 135                 140                 


Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn Gly Ser 
145                 150                 155                 160 


Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Val Ala Pro Leu Thr Pro 
                165                 170                 175     


Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile Asp Ser 
            180                 185                 190         


Arg Val Cys Ile Lys Thr Pro Ala Pro Ala Pro Pro Gly Asp Val Leu 
        195                 200                 205             


Ser Ala Leu Leu His Ser Gly Leu Ala Val Leu Phe Leu Ser Leu Pro 
    210                 215                 220                 


Ala Pro Leu Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg Leu Leu 
225                 230                 235                 240 


Arg Pro Val Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr Leu Cys 
                245                 250                 255     


Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Gly Gly Arg His 
            260                 265                 270         


Thr Gly Pro Ser Glu Gln Ser Glu Glu Asp Leu Gly Pro Gly Leu Ser 
        275                 280                 285             


Val Leu Gly Gly Leu Phe Leu Leu Phe Met Leu Glu Asn Thr Leu Gly 
    290                 295                 300                 


Leu Val Arg His Arg Gly Leu Arg Pro Arg Cys Cys Arg Asn Lys Arg 
305                 310                 315                 320 


Asp Leu Gly Glu Pro Asn Pro Asp Pro Glu Asp Gly Ser Gly Met Val 
                325                 330                 335     


Leu Arg Pro Leu Gln Ala Ala Ser Glu Pro Glu Val Gln Gly Gln Arg 
            340                 345                 350         


Glu Asn Arg Gln Ser Ser Pro Ser Leu Ala Pro Pro Gly His Gln Gly 
        355                 360                 365             


His Ser His Glu His Arg Gly Gly Ser Ile Ala Trp Met Val Leu Leu 
    370                 375                 380                 


Gly Asp Cys Leu His Asn Leu Thr Asp Gly Leu Ala Leu Gly Ala Ala 
385                 390                 395                 400 


Phe Ser Asp Gly Phe Ser Ser Gly Leu Ser Thr Thr Leu Ala Val Phe 
                405                 410                 415     


Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Met Leu Leu Gln 
            420                 425                 430         


Glu Gly Leu Ser Phe Arg Lys Leu Leu Leu Leu Ser Leu Val Ser Gly 
        435                 440                 445             


Ala Leu Gly Leu Gly Gly Ala Ala Leu Gly Val Gly Leu Ser Leu Gly 
    450                 455                 460                 


Pro Val Pro Leu Thr Pro Trp Val Phe Gly Thr Thr Ala Gly Val Phe 
465                 470                 475                 480 


Leu Tyr Val Ala Leu Val Asp Met Leu Pro Thr Leu Leu Arg Pro Pro 
                485                 490                 495     


Glu Pro Leu Pro Val Phe His Val Leu Leu Gln Gly Leu Gly Leu Leu 
            500                 505                 510         


Leu Gly Gly Ser Leu Met Phe Thr Ile Ala Leu Leu Glu Glu Gln Leu 
        515                 520                 525             


Val Pro Thr Val Pro Asp Gly 
    530                 535 


<210>  5
<211>  2828
<212>  DNA
<213>  Rattus norvegicus

<400>  5
gtgacgtggc ttccactgca tctgaagact gaactccctg actcagaaat ctcttaaggt       60

ccacagtgag gccctccagg gacctgaggt gccattagga gtgaggccct gcatatgtgg      120

gggtgagggg agtagggcgg tggaacaggt taagaggtgg gtcttgggga tctgagatac      180

tagtctggtt tctagaccag acctaaggag agctctgggg tcaggaggct gctccagaag      240

gcagaaggaa ggggcagagt aagcctgagg ctgcagaggc tgcagaggct gcagatagac      300

tcaggtacaa tcctcaggat gtcccaaagg aaatagaagt cagaaccaga gcctctaacc      360

catagcccta gtgatggggc cccccgtaca tcatctgttg gctggcctgt gtgtgggggt      420

ggccttgggc tgggtagaag gctcagtccc caacctgggc ccagccgaac aggaacagaa      480

ccactacctg gcccagctgt tcggtctata tggagagaat gggacattga ctgctggggg      540

cctggcccgg cttctccaca gcctaggact gggccgagtt caggggctcc gcctgggaca      600

ccaagagcct ccaactgggc gggctgcacc catgagtggc gacaatttca cacacaggct      660

tcaggaactg gagctgagtg tggatgtctg ggcaggaatg cctctgagcc cttcaggttg      720

gggtgaccag gaggactcaa aggcacatga cctgcatggg tcagggccct cgggcctaga      780

cctcttccac aggcttctgc tgctggacca ttcgttggct gaccatctga acgaggattg      840

tctgaatggt tcccagctgc tggtcaattt tgggctgagt cctgttgctc ctctgacccc      900

tcgtcagttt gctctgttgt gcccagccct gctttatcag attgacagcc gtgtttgcat      960

caaaacccct gctccagcac ctccagggga tgcactgtct gccctgcttc atagtggcct     1020

ggcagtcctg ttcctcagcc tccctgctcc cttctccctg ctgctgctgc ggctcttagg     1080

acctcgtctg ttgcggcctg tgctgggctt cctgggggcc ctggctgtgg gcactctttg     1140

tggggatgcc ctgctccacc tgctgccaca tgcacaagga ggacggcaca caggacctag     1200

tgagcaagca gaggaggatc tgggtccagg gctgtcagtg cttggtggcc tcttcctgct     1260

cttcgtgtta gagaatgcac taggacttgt gcggcacaga gggctcaggc caaggtgtgg     1320

caggaacaaa agggatgtcg aagaaccaaa ccctgaccca gaggacggca ctgggatggt     1380

ccttcggccc ctacaggcag cttcagaggt tcagggccag agggaaaaca gccagtccct     1440

accatctcca gcccctcccg gataccaagg ccacagtcat gagcaccggg gcggtagtat     1500

cgcatggatg gtcctcctgg gagattgcct gcacaacctc accgatgggc tcgcactagg     1560

tgctgccttt tccgacggct tctccagtgg cctcagcact accctagcag tcttctgcca     1620

tgagctgccc catgaactgg gtgactttgc aatgctgctt caggaagggc tgtcctttcg     1680

gaagctgctg ctgctgagcc tcgtctctgg agtcctgggg ctggggggtg cagccctggg     1740

ggtggggctc agcttgggcc ctgtccccct cactccctgg gtgtttggga tcacggctgg     1800

ggtcttcctc tatgtggccc ttgtggatat gctgccagcc ctgctccgtc ctcctgagcc     1860

ccggcccctg ccccatgtgc ttctgcaggg gctggggctg ctgctggggg gcagcctcat     1920

gtttactata gccctgttgg aggaacagct actgcccgtg gttcctgatg gctgatgtgg     1980

gccagtggca aaggatgcag gctgcccttc cttcccccca ccacaggaac ggaggcggga     2040

cacagggcca gtaggagcaa taggatttta ataaacagaa cccatcccaa agccatgact     2100

acgacagttg tacttgcacc aaaacagcat agaaaaccgg ggtgtagtgg gagggctcaa     2160

agcaggtttg gggaggacaa gcatggggga gggcctggag gttgtggggt gcatcagtct     2220

tcagggatag cattgtgctt tagcccaggt gggggggcag ggcaaatgca ccaaggtccc     2280

catttttttc tgctgccctc agcaccctgg agatgcaggt atctgggcct attgctgccc     2340

accagcatta aacacccctg accccaacac tagcaccaca gggggatcca ggatagggag     2400

aagggcagga gtgaggaaat tgcttagaga aagattcaac tagaatccag tgaattgtgc     2460

tcagttctct ttacttccta caaccgagta catgggtcac agggtggagg gtgcaacggg     2520

acaggaacat gcccctccgt gccccccaac acgcctgcac acaggatggt ggtgtctgca     2580

gcatcacagg tcatgcaggg catggggaag gggttcacac acacatagat gcccacagtg     2640

gggaccagac agaacacccc tgaatataca cagctgtaca tggggaaccc caggtcccca     2700

cccaaacctc tcccctgtct tgctgttccc cagcaggaga actgtattgc tttgagagag     2760

ccaccctggg gctgctctgc caggcaccct cccctcccac ccacccctat tttggcacat     2820

ctgcaaga                                                              2828


<210>  6
<211>  533
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Gly Pro Pro Val His His Leu Leu Ala Gly Leu Cys Val Gly Val 
1               5                   10                  15      


Ala Leu Gly Trp Val Glu Gly Ser Val Pro Asn Leu Gly Pro Ala Glu 
            20                  25                  30          


Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly Glu 
        35                  40                  45              


Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser Leu 
    50                  55                  60                  


Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly His Gln Glu Pro Pro 
65                  70                  75                  80  


Thr Gly Arg Ala Ala Pro Met Ser Gly Asp Asn Phe Thr His Arg Leu 
                85                  90                  95      


Gln Glu Leu Glu Leu Ser Val Asp Val Trp Ala Gly Met Pro Leu Ser 
            100                 105                 110         


Pro Ser Gly Trp Gly Asp Gln Glu Asp Ser Lys Ala His Asp Leu His 
        115                 120                 125             


Gly Ser Gly Pro Ser Gly Leu Asp Leu Phe His Arg Leu Leu Leu Leu 
    130                 135                 140                 


Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn Gly Ser 
145                 150                 155                 160 


Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Val Ala Pro Leu Thr Pro 
                165                 170                 175     


Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile Asp Ser 
            180                 185                 190         


Arg Val Cys Ile Lys Thr Pro Ala Pro Ala Pro Pro Gly Asp Ala Leu 
        195                 200                 205             


Ser Ala Leu Leu His Ser Gly Leu Ala Val Leu Phe Leu Ser Leu Pro 
    210                 215                 220                 


Ala Pro Phe Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg Leu Leu 
225                 230                 235                 240 


Arg Pro Val Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr Leu Cys 
                245                 250                 255     


Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Gly Gly Arg His 
            260                 265                 270         


Thr Gly Pro Ser Glu Gln Ala Glu Glu Asp Leu Gly Pro Gly Leu Ser 
        275                 280                 285             


Val Leu Gly Gly Leu Phe Leu Leu Phe Val Leu Glu Asn Ala Leu Gly 
    290                 295                 300                 


Leu Val Arg His Arg Gly Leu Arg Pro Arg Cys Gly Arg Asn Lys Arg 
305                 310                 315                 320 


Asp Val Glu Glu Pro Asn Pro Asp Pro Glu Asp Gly Thr Gly Met Val 
                325                 330                 335     


Leu Arg Pro Leu Gln Ala Ala Ser Glu Val Gln Gly Gln Arg Glu Asn 
            340                 345                 350         


Ser Gln Ser Leu Pro Ser Pro Ala Pro Pro Gly Tyr Gln Gly His Ser 
        355                 360                 365             


His Glu His Arg Gly Gly Ser Ile Ala Trp Met Val Leu Leu Gly Asp 
    370                 375                 380                 


Cys Leu His Asn Leu Thr Asp Gly Leu Ala Leu Gly Ala Ala Phe Ser 
385                 390                 395                 400 


Asp Gly Phe Ser Ser Gly Leu Ser Thr Thr Leu Ala Val Phe Cys His 
                405                 410                 415     


Glu Leu Pro His Glu Leu Gly Asp Phe Ala Met Leu Leu Gln Glu Gly 
            420                 425                 430         


Leu Ser Phe Arg Lys Leu Leu Leu Leu Ser Leu Val Ser Gly Val Leu 
        435                 440                 445             


Gly Leu Gly Gly Ala Ala Leu Gly Val Gly Leu Ser Leu Gly Pro Val 
    450                 455                 460                 


Pro Leu Thr Pro Trp Val Phe Gly Ile Thr Ala Gly Val Phe Leu Tyr 
465                 470                 475                 480 


Val Ala Leu Val Asp Met Leu Pro Ala Leu Leu Arg Pro Pro Glu Pro 
                485                 490                 495     


Arg Pro Leu Pro His Val Leu Leu Gln Gly Leu Gly Leu Leu Leu Gly 
            500                 505                 510         


Gly Ser Leu Met Phe Thr Ile Ala Leu Leu Glu Glu Gln Leu Leu Pro 
        515                 520                 525             


Val Val Pro Asp Gly 
    530             


