                         SEQUENCE LISTING

<110>  KINDRED BIOSCIENCES, INC.
 
<120>  NGF ANTAGONISTS FOR MEDICAL USE

<130>  01157-0018-00PCT

<150>  US 62/821,438
<151>  2019-03-20

<160>  246   

<170>  PatentIn version 3.5

<210>  1
<211>  796
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<223>  Canine TrkA

<400>  1

Met Leu Arg Gly Gly Arg Leu Gly Gln Arg Gly Gly His Gly Arg Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Val Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Val Cys Cys Pro His Gly Pro Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Ala Gly Ala Leu Gln Ser Leu His Arg Leu Pro Gly 
    50                  55                  60                  


Val Glu Asn Leu Thr Glu Leu Tyr Ile Asp Asn Gln Glu His Leu Gln 
65                  70                  75                  80  


His Leu Asp Ala Val His Leu Lys Gly Leu Gly Met Leu Arg Asp Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Ser Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Arg Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Pro Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu His Trp Leu Leu 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Gly Gln Arg Leu Gln 
                165                 170                 175     


Cys Pro Gly Gln Gly Pro Leu Ala Leu Leu Ser Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Val Leu Lys Val Gln Met Pro Asn Ala Ser Val Glu Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Gln Cys Gln Val Glu Gly Arg Gly Leu Glu Arg 
    210                 215                 220                 


Ala Gly Trp Ile Leu Pro Glu Val Glu Glu Leu Ala Thr Val Thr Pro 
225                 230                 235                 240 


Ser Gly Asp Leu Pro Ser Leu Gly Leu Ile Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly 
        355                 360                 365             


Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Gly Gln Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Phe Leu Ala Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Gly Asn Arg Ala Val Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Gln Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Val Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Gln Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Glu Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  2
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v1)

<400>  2

Met Leu Arg Gly Gly Arg Leu Gly Gln Arg Gly Gly His Gly Arg Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Val Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Val Cys Cys Pro His Gly Pro Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Ala Gly Ala Leu Gln Ser Leu His Arg Leu Pro Gly 
    50                  55                  60                  


Val Glu Asn Leu Thr Glu Leu Tyr Ile Asp Asn Gln Glu His Leu Gln 
65                  70                  75                  80  


His Leu Asp Ala Val His Leu Lys Gly Leu Gly Met Leu Arg Asp Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Ser Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Arg Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Pro Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu His Trp Leu Leu 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Gly Gln Arg Leu Gln 
                165                 170                 175     


Cys Pro Gly Gln Gly Pro Leu Ala Leu Leu Ser Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Val Leu Lys Val Gln Met Pro Asn Ala Ser Val Glu Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Gln Cys Gln Val Glu Gly Arg Gly Leu Glu Arg 
    210                 215                 220                 


Ala Gly Trp Ile Leu Pro Glu Val Glu Glu Leu Ala Thr Val Thr Pro 
225                 230                 235                 240 


Ser Gly Asp Leu Pro Ser Leu Gly Leu Ile Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly 
        355                 360                 365             


Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Gly Gln Thr Pro Phe 
                405                 410                 415     


Gly 
    


<210>  3
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v2)

<400>  3

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp 
        115                 120                 125 


<210>  4
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v3)

<400>  4

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  5
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v4)

<400>  5

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  6
<211>  795
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<223>  Feline TrkA

<400>  6

Met Leu Arg Gly Gly Arg Gly Pro Arg Gly Gly His Gly Arg Ala Ala 
1               5                   10                  15      


Gly Pro Gly Ser Leu Leu Ala Trp Leu Met Leu Ala Ser Ala Gly Ala 
            20                  25                  30          


Ala Pro Cys Ala Asp Val Cys Cys Pro His Gly Pro Ser Gly Leu Arg 
        35                  40                  45              


Cys Thr Arg Ala Gly Ala Leu Glu Ser Leu Arg Arg Leu Pro Gly Ala 
    50                  55                  60                  


Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Glu Arg Leu Arg His 
65                  70                  75                  80  


Leu Glu Pro Ser Asp Leu Arg Gly Leu Gly Glu Leu Arg Gly Leu Thr 
                85                  90                  95      


Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Val Phe His Phe 
            100                 105                 110         


Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu Ser 
        115                 120                 125             


Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val Leu 
    130                 135                 140                 


Ser Gly Asn Pro Leu Arg Cys Ser Cys Ala Leu His Trp Leu Leu Arg 
145                 150                 155                 160 


Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Ala Gln Arg Leu Gln Cys 
                165                 170                 175     


Pro Gly Gln Gly Pro Leu Ala Leu Leu Ser Asn Ala Ser Cys Gly Val 
            180                 185                 190         


Pro Val Leu Lys Val Gln Thr Pro Asn Ala Ser Val Asn Val Gly Asp 
        195                 200                 205             


Asp Val Leu Leu Gln Cys Gln Val Glu Gly Arg Gly Leu Glu Gln Ala 
    210                 215                 220                 


Gly Trp Ile Leu Thr Glu Leu Glu Glu Ser Ala Thr Val Thr Gln Ser 
225                 230                 235                 240 


Gly Ala Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser Asp 
                245                 250                 255     


Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly Arg 
            260                 265                 270         


Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val Gln 
        275                 280                 285             


Leu His Ala Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val 
    290                 295                 300                 


Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val 
305                 310                 315                 320 


Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala 
                325                 330                 335     


Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His 
            340                 345                 350         


Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg 
        355                 360                 365             


Ala Ala Ala Ser Val Leu Ala Ala Phe Met Asp Asn Pro Phe Glu Phe 
    370                 375                 380                 


Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Ser Asn 
385                 390                 395                 400 


Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly 
                405                 410                 415     


Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Leu Leu Ser 
            420                 425                 430         


Ala Phe Phe Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly 
        435                 440                 445             


Ile Asn Arg Thr Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser 
    450                 455                 460                 


Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly 
465                 470                 475                 480 


Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe 
                485                 490                 495     


Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys 
            500                 505                 510         


Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys 
        515                 520                 525             


Tyr Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala 
    530                 535                 540                 


Leu Lys Glu Val Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala 
545                 550                 555                 560 


Gln Leu Leu Thr Val Leu Gln His Gln His Ile Val Arg Phe Phe Gly 
                565                 570                 575     


Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg 
            580                 585                 590         


His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys 
        595                 600                 605             


Leu Leu Ala Gly Arg Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Ser 
    610                 615                 620                 


Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu 
625                 630                 635                 640 


Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                645                 650                 655     


Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg 
            660                 665                 670         


Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu 
        675                 680                 685             


Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr 
    690                 695                 700                 


Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe 
705                 710                 715                 720 


Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile 
                725                 730                 735     


Glu Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro 
            740                 745                 750         


Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln 
        755                 760                 765             


Gln Arg His Ser Ile Lys Glu Val His Ala Arg Leu Gln Ala Leu Ala 
    770                 775                 780                 


Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795 


<210>  7
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v1)

<400>  7

Met Leu Arg Gly Gly Arg Gly Pro Arg Gly Gly His Gly Arg Ala Ala 
1               5                   10                  15      


Gly Pro Gly Ser Leu Leu Ala Trp Leu Met Leu Ala Ser Ala Gly Ala 
            20                  25                  30          


Ala Pro Cys Ala Asp Val Cys Cys Pro His Gly Pro Ser Gly Leu Arg 
        35                  40                  45              


Cys Thr Arg Ala Gly Ala Leu Glu Ser Leu Arg Arg Leu Pro Gly Ala 
    50                  55                  60                  


Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Glu Arg Leu Arg His 
65                  70                  75                  80  


Leu Glu Pro Ser Asp Leu Arg Gly Leu Gly Glu Leu Arg Gly Leu Thr 
                85                  90                  95      


Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Val Phe His Phe 
            100                 105                 110         


Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu Ser 
        115                 120                 125             


Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val Leu 
    130                 135                 140                 


Ser Gly Asn Pro Leu Arg Cys Ser Cys Ala Leu His Trp Leu Leu Arg 
145                 150                 155                 160 


Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Ala Gln Arg Leu Gln Cys 
                165                 170                 175     


Pro Gly Gln Gly Pro Leu Ala Leu Leu Ser Asn Ala Ser Cys Gly Val 
            180                 185                 190         


Pro Val Leu Lys Val Gln Thr Pro Asn Ala Ser Val Asn Val Gly Asp 
        195                 200                 205             


Asp Val Leu Leu Gln Cys Gln Val Glu Gly Arg Gly Leu Glu Gln Ala 
    210                 215                 220                 


Gly Trp Ile Leu Thr Glu Leu Glu Glu Ser Ala Thr Val Thr Gln Ser 
225                 230                 235                 240 


Gly Ala Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser Asp 
                245                 250                 255     


Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly Arg 
            260                 265                 270         


Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val Gln 
        275                 280                 285             


Leu His Ala Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val 
    290                 295                 300                 


Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val 
305                 310                 315                 320 


Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala 
                325                 330                 335     


Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His 
            340                 345                 350         


Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg 
        355                 360                 365             


Ala Ala Ala Ser Val Leu Ala Ala Phe Met Asp Asn Pro Phe Glu Phe 
    370                 375                 380                 


Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Ser Asn 
385                 390                 395                 400 


Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly 
                405                 410                 415     


<210>  8
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v2)

<400>  8

Val Ser Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Ser Asn Ser Thr Ser Gly Asp 
        115                 120                 125 


<210>  9
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v3)

<400>  9

Val Ser Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  10
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v4)

<400>  10

Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  11
<211>  796
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<223>  Equine TrkA

<400>  11

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Gly Arg Ala 
1               5                   10                  15      


Thr Gly Pro Gly Ser Leu Leu Ala Trp Leu Met Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Pro Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Gln Pro Gly Ala Leu Asp Ser Leu Arg His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln Asn Leu Gln 
65                  70                  75                  80  


Arg Leu Glu Arg Asn Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu His Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Lys 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Gln Leu Val 
    130                 135                 140                 


Leu Leu Gly Asn Pro Leu Asp Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gln Gln Gly Pro Leu Ala Leu Met Ser Asn Thr Asn Cys Gly 
            180                 185                 190         


Val Pro Leu Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asn Val Trp Leu Gln Cys Gln Val Glu Gly Gln Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Glu Ser Ala Thr Val Met Gln 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


His Leu Gln Thr Ala Val Glu Gln His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala 
                325                 330                 335     


Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly 
        355                 360                 365             


Gln Asp Ser Ala Ser Val Met Val Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Arg Asp Pro Val Glu Lys Lys Asp Glu Thr His Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Phe Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Val Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Glu Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Val Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  12
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v1)

<400>  12

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Gly Arg Ala 
1               5                   10                  15      


Thr Gly Pro Gly Ser Leu Leu Ala Trp Leu Met Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Pro Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Gln Pro Gly Ala Leu Asp Ser Leu Arg His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln Asn Leu Gln 
65                  70                  75                  80  


Arg Leu Glu Arg Asn Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu His Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Lys 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Gln Leu Val 
    130                 135                 140                 


Leu Leu Gly Asn Pro Leu Asp Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Arg Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gln Gln Gly Pro Leu Ala Leu Met Ser Asn Thr Asn Cys Gly 
            180                 185                 190         


Val Pro Leu Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asn Val Trp Leu Gln Cys Gln Val Glu Gly Gln Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Glu Ser Ala Thr Val Met Gln 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


His Leu Gln Thr Ala Val Glu Gln His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala 
                325                 330                 335     


Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly 
        355                 360                 365             


Gln Asp Ser Ala Ser Val Met Val Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Arg Asp Pro Val Glu Lys Lys Asp Glu Thr His Phe 
                405                 410                 415     


Gly 
    


<210>  13
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v2)

<400>  13

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg Asp 
        115                 120                 125 


<210>  14
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v3)

<400>  14

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  15
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v4)

<400>  15

Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  16
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - wildtype canine IgG-B 
       Fc with signal sequence Protein A+ C1q + CD16 +

<400>  16

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  17
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - wildtype canine IgG-B 
       Fc with signal sequence Protein A+ C1q + CD16 +

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  18
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - wildtype canine IgG-B 
       Fc with signal sequence Protein A+ C1q + CD16 +

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  19
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v2 - wildtype feline IgG2 Fc
       with signal sequence  Protein A + C1q - CD16 -

<400>  19

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Ala Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Ser Val Leu Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Ser Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Thr Ala 
145                 150                 155                 160 


Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys Cys Pro Val Pro 
                165                 170                 175     


Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
            180                 185                 190         


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
        195                 200                 205             


Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr Trp Phe Val Asp 
    210                 215                 220                 


Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe 
225                 230                 235                 240 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
                245                 250                 255     


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
            260                 265                 270         


Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
        275                 280                 285             


Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu 
    290                 295                 300                 


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe His Pro Pro Asp 
305                 310                 315                 320 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
                325                 330                 335     


Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
            340                 345                 350         


Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
        355                 360                 365             


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
    370                 375                 380                 


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
385                 390             


<210>  20
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v3 - wildtype feline IgG2 Fc
       with signal sequence Protein A + C1q - CD16 -

<400>  20

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Ala Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Ser Val Leu Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly 
    130                 135                 140                 


Glu Gly Pro Lys Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val 
145                 150                 155                 160 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr 
                165                 170                 175     


Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn 
            180                 185                 190         


Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys 
        195                 200                 205             


Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    210                 215                 220                 


Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys 
225                 230                 235                 240 


Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile 
                245                 250                 255     


Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro 
            260                 265                 270         


Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu 
        275                 280                 285             


Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr 
    290                 295                 300                 


Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg 
                325                 330                 335     


Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu 
            340                 345                 350         


Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly 
        355                 360                 365             


Lys 
    


<210>  21
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v4 - wildtype feline IgG2 Fc
       with signal sequence  Protein A + C1q - CD16 -

<400>  21

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Ala Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser 
            100                 105                 110         


Val Leu Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly 
    130                 135                 140                 


Pro Lys Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln 
            180                 185                 190         


Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg 
        195                 200                 205             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
225                 230                 235                 240 


Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr 
            260                 265                 270         


Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
        275                 280                 285             


Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
    290                 295                 300                 


Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser 
305                 310                 315                 320 


Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His 
                325                 330                 335     


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
            340                 345                 350         


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
        355                 360                 365         


<210>  22
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v2 - variant equine IgG2 Fc 
       with signal sequence Protein A + C1q - CD16 -

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala 
            20                  25                  30          


Val Glu Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser 
            100                 105                 110         


Val Met Val Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp 
        115                 120                 125             


Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg 
    130                 135                 140                 


Asp Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser 
145                 150                 155                 160 


Val Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly 
                165                 170                 175     


Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
            180                 185                 190         


Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp 
        195                 200                 205             


Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val 
    210                 215                 220                 


His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr 
225                 230                 235                 240 


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
                245                 250                 255     


Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile 
            260                 265                 270         


Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val 
        275                 280                 285             


Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser 
    290                 295                 300                 


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu 
305                 310                 315                 320 


Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr 
                325                 330                 335     


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
            340                 345                 350         


Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala 
        355                 360                 365             


Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser 
    370                 375                 380                 


Glu Ser Leu Gly Lys 
385                 


<210>  23
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v3 - variant equine IgG2 Fc 
       with signal sequence Protein A + C1q - CD16 -

<400>  23

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala 
            20                  25                  30          


Val Glu Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser 
            100                 105                 110         


Val Met Val Ala Phe Met Asp Asn Pro Pro Pro Cys Val Leu Ser Ala 
        115                 120                 125             


Glu Gly Val Ile Pro Ile Pro Ser Val Pro Lys Pro Gln Cys Pro Pro 
    130                 135                 140                 


Tyr Thr His Ser Lys Phe Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
145                 150                 155                 160 


Pro Asn Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr 
                165                 170                 175     


Cys Val Val Val Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser 
            180                 185                 190         


Trp Tyr Val Asp Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg 
        195                 200                 205             


Glu Ala Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
    210                 215                 220                 


Gln His Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr 
225                 230                 235                 240 


Asn Val Gly Val Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys 
                245                 250                 255     


Gly Pro Ser Arg Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp 
            260                 265                 270         


Glu Leu Ala Lys Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe 
        275                 280                 285             


Tyr Pro Pro Asp Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu 
    290                 295                 300                 


Leu Glu Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly 
305                 310                 315                 320 


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln 
                325                 330                 335     


Gln Val Glu Ser Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly Lys 
        355                 360                 365 


<210>  24
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v4 - variant equine IgG2 Fc 
       with signal sequence Protein A + C1q - CD16 -

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu 
            20                  25                  30          


Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro 
        35                  40                  45              


Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe 
    50                  55                  60                  


Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His 
65                  70                  75                  80  


Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr 
                85                  90                  95      


Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met 
            100                 105                 110         


Val Ala Phe Met Asp Asn Pro Pro Pro Cys Val Leu Ser Ala Glu Gly 
        115                 120                 125             


Val Ile Pro Ile Pro Ser Val Pro Lys Pro Gln Cys Pro Pro Tyr Thr 
    130                 135                 140                 


His Ser Lys Phe Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val 
                165                 170                 175     


Val Val Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr 
            180                 185                 190         


Val Asp Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala 
        195                 200                 205             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His 
    210                 215                 220                 


Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val 
225                 230                 235                 240 


Gly Val Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro 
                245                 250                 255     


Ser Arg Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu 
            260                 265                 270         


Ala Lys Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro 
        275                 280                 285             


Pro Asp Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu 
    290                 295                 300                 


Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr 
305                 310                 315                 320 


Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val 
                325                 330                 335     


Glu Ser Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly Lys 
        355                 360             


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v2) Extra disulfide

<400>  25

Val Ser Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp 
        115                 120                 125 


<210>  26
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v3)  Extra disulfide

<400>  26

Val Ser Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  27
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD (v4)  Extra disulfide

<400>  27

Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v2)  Extra disulfide

<400>  28

Val Ser Phe Pro Ala Ser Cys Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Ser Asn Ser Thr Ser Gly Asp 
        115                 120                 125 


<210>  29
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v3)  Extra disulfide

<400>  29

Val Ser Phe Pro Ala Ser Cys Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  30
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD (v4)  Extra disulfide

<400>  30

Phe Pro Ala Ser Cys Gln Leu His Ala Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Cys Ala Ala Ser Val Leu Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v2)  Extra disulfide

<400>  31

Val Ser Phe Pro Ala Ser Cys His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Cys Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg Asp 
        115                 120                 125 


<210>  32
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v3)  Extra disulfide

<400>  32

Val Ser Phe Pro Ala Ser Cys His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Cys Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro 
            100     


<210>  33
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD (v4)  Extra disulfide

<400>  33

Phe Pro Ala Ser Cys His Leu Gln Thr Ala Val Glu Gln His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Thr Asn Pro Tyr Gly Gln Cys Ser Ala Ser Val Met Val Ala Phe Met 
                85                  90                  95      


Asp Asn Pro 
            


<210>  34
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-A Fc   Protein A - C1q 
       - CD16 -

<400>  34

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  35
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc   Protein A + C1q 
       + CD16 +

<400>  35

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  36
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc with hinge  
       Protein A + C1q + CD16 +

<400>  36

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
        115                 120                 125             


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
145                 150                 155                 160 


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
                165                 170                 175     


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
            180                 185                 190         


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235         


<210>  37
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc   Protein A -  C1q
       + CD16 +

<400>  37

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  38
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc with hinge   
       Protein A -  C1q + CD16 +

<400>  38

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                85                  90                  95      


Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln 
        115                 120                 125             


Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met 
    130                 135                 140                 


Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro 
145                 150                 155                 160 


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                165                 170                 175     


Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        195                 200                 205             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235 


<210>  39
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-D Fc   Protein A - C1q 
       - CD16 -

<400>  39

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  40
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q - CD16 - 
       Protein A + I(21)T R(23)L T(25)A E(80)G T(205)A Q(207)H

<400>  40

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  41
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T V(23)L T(24)I

<400>  41

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  42
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q - CD16 - 
       Protein A + I(21)T R(23)L T(25)A E(80)G Q(207)H

<400>  42

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  43
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q - CD16 - 
       Protein A + I(21)T Q(207)H

<400>  43

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  44
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T

<400>  44

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  45
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q - Protein A + 
       I(21)T Q(207)H

<400>  45

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  46
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q -  
       K(93)R

<400>  46

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  47
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q -  
       CD16 + K(93)R

<400>  47

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  48
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  M(5)P

<400>  48

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  49
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  P(39)R

<400>  49

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  50
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  D(38)G

<400>  50

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  51
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  D(38)G P(39)R

<400>  51

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  52
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  K(97)I

<400>  52

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  53
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  A(98)G

<400>  53

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  54
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16 - D(38)G  K(97)I A(98)G

<400>  54

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  55
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 -  M(5)P P(39)R

<400>  55

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  56
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  L(5)P

<400>  56

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  57
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  P(39)R

<400>  57

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  58
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  D(38)G

<400>  58

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  59
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  K(97)I

<400>  59

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  60
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  A(98)G

<400>  60

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  61
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q +  
       CD16 -  L(5)P P(39)R

<400>  61

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  62
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q + 
       CD16 - D(38)G  K(97)I A(98)G

<400>  62

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  63
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q -   K(93)R  
       Protein A + I(21)T V(23)L T(24)I

<400>  63

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  64
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q - 
       CD16 - K(93)R K(97)I A(98)G

<400>  64

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  65
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q - 
       CD16 - D(38)G  K(93)R K(97)I A(98)G

<400>  65

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  66
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q - 
       CD16 - M(5)P P(39)R K(93)R

<400>  66

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  67
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q - 
       CD16 -  M(5)P D(38)G P(39)R K(93)R

<400>  67

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  68
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q - 
       CD16 - D(38)G  K(93)R K(97)I A(98)G

<400>  68

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  69
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A - C1q - 
       CD16 - M(5)P P(39)R K(93)R

<400>  69

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  70
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG1 Fc   Protein A + C1q +

<400>  70

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu 
        35                  40                  45              


Val Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Gln Pro 
                85                  90                  95      


Ile Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Ser Lys Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile 
    130                 135                 140                 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  71
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG2 Fc  Protein A - C1q -

<400>  71

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  72
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG2 Fc with hinge  Protein
       A - C1q -

<400>  72

Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  73
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG3 Fc  Protein A + C1q+

<400>  73

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser 
            20                  25                  30          


His Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu 
        35                  40                  45              


Val Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Lys Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr 
145                 150                 155                 160 


Thr Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  74
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG4 Fc  Protein A + C1q +

<400>  74

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  75
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG5 Fc  Protein A - C1q -

<400>  75

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
            20                  25                  30          


His Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Val Glu Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser His Ser Pro Gly Lys 
    210                 


<210>  76
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG6 Fc  Protein A - C1q -

<400>  76

Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Ala His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Gln 
            100                 105                 110         


Val Tyr Ile Leu Ala Pro His Pro Asp Glu Val Thr Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Ile Arg His Thr Tyr Arg Gln Lys Ser Ile 
        195                 200                 205             


Thr Asn Phe Pro Gly Lys 
    210                 


<210>  77
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG7 Fc  Protein A + C1q +

<400>  77

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  78
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  C1q - Protein A + 
       F(203)Y

<400>  78

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  79
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  C1q - Protein A + 
       A(15)T F(203)Y

<400>  79

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  80
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG5 Fc  C1q - Protein A + 
       V(199)L E(200)H

<400>  80

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
            20                  25                  30          


His Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser His Ser Pro Gly Lys 
    210                 


<210>  81
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG6 Fc  C1q - Protein A + 
       I(199)L  R(200)H H(201)N T(202)H

<400>  81

Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Ala His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Gln 
            100                 105                 110         


Val Tyr Ile Leu Ala Pro His Pro Asp Glu Val Thr Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Tyr Arg Gln Lys Ser Ile 
        195                 200                 205             


Thr Asn Phe Pro Gly Lys 
    210                 


<210>  82
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG1 Fc   Protein A + C1q -  
       K(87)S

<400>  82

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu 
        35                  40                  45              


Val Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Gln Pro 
                85                  90                  95      


Ile Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Ser Lys Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile 
    130                 135                 140                 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  83
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG3 Fc  Protein A + C1q -  
       K(87)S

<400>  83

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser 
            20                  25                  30          


His Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu 
        35                  40                  45              


Val Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Lys Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr 
145                 150                 155                 160 


Thr Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  84
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG4 Fc  Protein A + C1q -  
       K(87)S

<400>  84

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  85
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG7 Fc  Protein A + C1q -  
       K(87)S

<400>  85

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  86
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  86

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  87
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  87

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  88
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  88

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  89
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  89

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  90
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG2 Fc  Protein A + C1q -

<400>  90

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  91
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q - 
       P(198)A

<400>  91

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  92
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q - 
       P(198)A

<400>  92

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  93
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q - 
       P(198)A

<400>  93

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  94
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q - 
       P(198)A

<400>  94

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  95
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc   Hinge Cys G(14)C

<400>  95

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Cys Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  96
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc with modified hinge 
       K(16)P

<400>  96

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  97
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc with modified hinge 
       K(16)P

<400>  97

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  98
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc with modified hinge 
       K(16)P

<400>  98

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  99
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc with modified hinge 
       K(16)P

<400>  99

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  100
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc with modified hinge  
       K(16)P

<400>  100

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Pro 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  101
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with modified hinge  
       Protein A - C1q - Q(20)P

<400>  101

Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Pro Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  102
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with modified hinge  
       Protein A - C1q - C(3)S

<400>  102

Pro Pro Ser Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  103
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with modified hinge  
       Protein A - C1q - C(3)S Q(20)P

<400>  103

Pro Pro Ser Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Pro Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  104
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with hinge  Protein A
       + C1q - A(45)T F(233)Y

<400>  104

Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  105
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with modified hinge  
       Protein A + C1q - Q(20)P A(45)T F(233)Y

<400>  105

Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Pro Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  106
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc with modified hinge  
       Protein A + C1q - C(3)S Q(20)P A(45)T F(233)Y

<400>  106

Pro Pro Ser Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Pro Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  107
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc with feline IgG1 
       hinge

<400>  107

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  108
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine Fc IgG2 (with equine IgG1 
       hinge)  Protein A -  C1q -

<400>  108

Asp Met Ser Lys Cys Pro Lys Cys Pro Ala Pro Glu Leu Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
        35                  40                  45              


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
    50                  55                  60                  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
                85                  90                  95      


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
            100                 105                 110         


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
        115                 120                 125             


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
    130                 135                 140                 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
145                 150                 155                 160 


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
                165                 170                 175     


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            180                 185                 190         


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  109
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc (with equine IgG1 
       hinge)  C1q - Protein A + A(29)T F(217)Y

<400>  109

Asp Met Ser Lys Cys Pro Lys Cys Pro Ala Pro Glu Leu Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
        35                  40                  45              


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
    50                  55                  60                  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
                85                  90                  95      


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
            100                 105                 110         


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
        115                 120                 125             


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
    130                 135                 140                 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
145                 150                 155                 160 


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
                165                 170                 175     


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            180                 185                 190         


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  110
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A+ C1q - CD16 -

<400>  110

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  111
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A+ C1q - CD16 -

<400>  111

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  112
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A+ C1q - CD16 -

<400>  112

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  113
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-A Fc
       with signal sequence C1q - Protein A +

<400>  113

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe Asn Glu Cys 
145                 150                 155                 160 


Arg Cys Thr Asp Thr Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp 
        195                 200                 205             


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr 
    210                 215                 220                 


Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr Gly Lys Glu 
                245                 250                 255     


Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg 
            260                 265                 270         


Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val 
        275                 280                 285             


Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile 
    290                 295                 300                 


Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp 
305                 310                 315                 320 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro 
                325                 330                 335     


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser Leu Ser His 
    370                 375                 380                 


Ser Pro Gly Lys 
385             


<210>  114
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-A Fc
       with signal sequence C1q - Protein A +

<400>  114

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Cys Pro 
    130                 135                 140                 


Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
            180                 185                 190         


Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln 
        195                 200                 205             


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
    210                 215                 220                 


Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile 
225                 230                 235                 240 


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg 
                245                 250                 255     


Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu 
            260                 265                 270         


Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr 
        275                 280                 285             


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
    290                 295                 300                 


Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
305                 310                 315                 320 


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360                 


<210>  115
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-A Fc
       with signal sequence C1q - Protein A +

<400>  115

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Cys Pro Val Pro 
    130                 135                 140                 


Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Leu 
                165                 170                 175     


Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp 
            180                 185                 190         


Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe 
        195                 200                 205             


Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp 
    210                 215                 220                 


Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu 
225                 230                 235                 240 


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His 
                245                 250                 255     


Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser 
            260                 265                 270         


Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg 
    290                 295                 300                 


Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp 
                325                 330                 335     


Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  116
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-D Fc
       with signal sequence C1q - Protein A +

<400>  116

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Glu Ser 
145                 150                 155                 160 


Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
            180                 185                 190         


Ala Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu 
        195                 200                 205             


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His 
    210                 215                 220                 


Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr Gly Lys 
                245                 250                 255     


Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu 
            260                 265                 270         


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
        275                 280                 285             


Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr 
    290                 295                 300                 


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu 
305                 310                 315                 320 


Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr 
                325                 330                 335     


Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
            340                 345                 350         


Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala 
        355                 360                 365             


Val Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser Leu Ser 
    370                 375                 380                 


His Ser Pro Gly Lys 
385                 


<210>  117
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-D Fc
       with signal sequence  C1q - Protein A +

<400>  117

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys 
    130                 135                 140                 


Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys 
                165                 170                 175     


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
            180                 185                 190         


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
        195                 200                 205             


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
    210                 215                 220                 


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
225                 230                 235                 240 


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
                245                 250                 255     


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
            260                 265                 270         


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
        275                 280                 285             


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
305                 310                 315                 320 


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360                 365 


<210>  118
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-D Fc
       with signal sequence C1q - Protein A +

<400>  118

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val 
    130                 135                 140                 


Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys Val Val 
                165                 170                 175     


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln 
        195                 200                 205             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
            260                 265                 270         


Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
        275                 280                 285             


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu 
    290                 295                 300                 


Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
305                 310                 315                 320 


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
                325                 330                 335     


Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360             


<210>  119
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v2 - variant equine  IgG2 
       with IgG1 hinge with signal sequence C1q - Protein A +

<400>  119

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala 
            20                  25                  30          


Val Glu Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser 
            100                 105                 110         


Val Met Val Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp 
        115                 120                 125             


Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg 
    130                 135                 140                 


Asp Asp Met Ser Lys Cys Pro Lys Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp 
            180                 185                 190         


Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val 
        195                 200                 205             


His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
225                 230                 235                 240 


Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile 
                245                 250                 255     


Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val 
            260                 265                 270         


Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser 
        275                 280                 285             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu 
    290                 295                 300                 


Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr 
305                 310                 315                 320 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser 
        355                 360                 365             


Glu Ser Leu Gly Lys 
    370             


<210>  120
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v3 - variant equine  IgG2 
       with IgG1 hinge with signal sequence C1q - Protein A +

<400>  120

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala 
            20                  25                  30          


Val Glu Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser 
            100                 105                 110         


Val Met Val Ala Phe Met Asp Asn Pro Asp Met Ser Lys Cys Pro Lys 
        115                 120                 125             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Asn Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser 
                165                 170                 175     


Trp Tyr Val Asp Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg 
            180                 185                 190         


Glu Ala Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
        195                 200                 205             


Gln His Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr 
    210                 215                 220                 


Asn Val Gly Val Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys 
225                 230                 235                 240 


Gly Pro Ser Arg Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp 
                245                 250                 255     


Glu Leu Ala Lys Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe 
            260                 265                 270         


Tyr Pro Pro Asp Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu 
        275                 280                 285             


Leu Glu Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly 
    290                 295                 300                 


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Val Glu Ser Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly Lys 
            340                 345                 


<210>  121
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v4 - variant equine  IgG2 
       with IgG1 hinge with signal sequence C1q - Protein A +

<400>  121

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu 
            20                  25                  30          


Gln His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro 
        35                  40                  45              


Thr Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe 
    50                  55                  60                  


Ile Phe Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His 
65                  70                  75                  80  


Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr 
                85                  90                  95      


Thr Leu Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met 
            100                 105                 110         


Val Ala Phe Met Asp Asn Pro Asp Met Ser Lys Cys Pro Lys Cys Pro 
        115                 120                 125             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
    130                 135                 140                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val 
145                 150                 155                 160 


Val Val Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr 
                165                 170                 175     


Val Asp Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala 
            180                 185                 190         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His 
        195                 200                 205             


Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val 
    210                 215                 220                 


Gly Val Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro 
225                 230                 235                 240 


Ser Arg Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu 
                245                 250                 255     


Ala Lys Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro 
            260                 265                 270         


Pro Asp Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu 
        275                 280                 285             


Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr 
    290                 295                 300                 


Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val 
305                 310                 315                 320 


Glu Ser Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly Lys 
            340                 345         


<210>  122
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Extra disulfide Protein A+ C1q - CD16 -

<400>  122

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Cys Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  123
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Extra disulfide Protein A+ C1q - CD16 -

<400>  123

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Cys Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  124
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Extra disulfide Protein A+ C1q - CD16 -

<400>  124

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Cys Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  125
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 -

<400>  125

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  126
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 -

<400>  126

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  127
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 -

<400>  127

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  128
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q - CD16 -

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  129
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q - CD16 -

<400>  129

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  130
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q - CD16 -

<400>  130

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
                165                 170                 175     


Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  131
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 x2 - variant canine IgG-B
       Fc with signal sequence Protein A + C1q - CD16 -

<400>  131

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala 
    130                 135                 140                 


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
145                 150                 155                 160 


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
                165                 170                 175     


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
            180                 185                 190         


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
    210                 215                 220                 


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
        275                 280                 285             


Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
    290                 295                 300                 


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
                325                 330                 335     


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  132
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc - canine TrkA ECD v3
       with signal sequence Protein A + C1q - CD16 -

<400>  132

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
            20                  25                  30          


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
        35                  40                  45              


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
    50                  55                  60                  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp 
65                  70                  75                  80  


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
                85                  90                  95      


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
            100                 105                 110         


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
        115                 120                 125             


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
    130                 135                 140                 


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
145                 150                 155                 160 


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
                165                 170                 175     


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
            180                 185                 190         


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
        195                 200                 205             


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
    210                 215                 220                 


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
225                 230                 235                 240 


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
                245                 250                 255     


Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Val Ser Phe Pro Ala Ser 
            260                 265                 270         


Val Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe 
        275                 280                 285             


Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly 
    290                 295                 300                 


Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro 
305                 310                 315                 320 


Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro 
                325                 330                 335     


Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser 
            340                 345                 350         


Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro 
        355                 360                 365         


<210>  133
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       - canine TrkA ECD v3 with signal sequence Protein A + C1q - CD16 
       -

<400>  133

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Val 
        355                 360                 365             


Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His 
    370                 375                 380                 


Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg 
385                 390                 395                 400 


Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr 
                405                 410                 415     


Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu 
            420                 425                 430         


Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu 
        435                 440                 445             


Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe 
    450                 455                 460                 


Met Asp Asn Pro 
465             


<210>  134
<211>  541
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<223>  Canine NGFR

<400>  134

Met Ala Ile Ala Gly Asp Asn Arg Val Ala Val Thr Val Ala Met Gly 
1               5                   10                  15      


Arg Ile Val Gly Val Val Ala Met Ala Val Val Ala Val Val Val Leu 
            20                  25                  30          


Val Val Met Pro Val Ser Trp Leu Arg Gly Gly Arg Ala Arg Phe Arg 
        35                  40                  45              


Gly Trp Ala Gly Trp Ala Gly Arg Arg Arg Gly Arg Arg Thr Gly Phe 
    50                  55                  60                  


Ser Gln Pro Leu Pro Pro Ser Ala Arg Ala Ser Gly Ala Ser Ala Ser 
65                  70                  75                  80  


Ser Gly Gly Arg Ala Leu Glu Arg Ser Ala Ala Gln Pro Tyr Pro Ser 
                85                  90                  95      


Ala Glu Arg Thr Pro Leu Glu Ala Glu Arg Cys His Arg Arg Arg Ala 
            100                 105                 110         


Val Gly Ala Gly Ala Ala Gly Cys Ala Met Asp Gly Pro Arg Leu Leu 
        115                 120                 125             


Leu Leu Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu 
    130                 135                 140                 


Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
145                 150                 155                 160 


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
                165                 170                 175     


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
            180                 185                 190         


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
        195                 200                 205             


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
    210                 215                 220                 


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
225                 230                 235                 240 


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Arg Gln 
                245                 250                 255     


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
            260                 265                 270         


Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu 
        275                 280                 285             


Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu 
    290                 295                 300                 


Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Ser Glu Asp Ser Asp 
305                 310                 315                 320 


Ser Thr Ala Pro Ser Thr Glu Glu Pro Glu Leu Pro Pro Asp Gln Glu 
                325                 330                 335     


Ile Ile Ala Ser Thr Met Ala Asp Val Val Thr Thr Val Met Gly Ser 
            340                 345                 350         


Ser Gln Pro Val Val Thr Arg Gly Thr Ala Asp Asn Leu Ile Pro Val 
        355                 360                 365             


Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile 
    370                 375                 380                 


Ala Phe Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn 
385                 390                 395                 400 


Ser Arg Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His 
                405                 410                 415     


Ser Asp Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln 
            420                 425                 430         


Pro His Thr Gln Thr Ala Ala Gly Gln Ala Leu Lys Gly Asp Gly Gly 
        435                 440                 445             


Leu Tyr Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu 
    450                 455                 460                 


Leu Asn Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu 
465                 470                 475                 480 


Gly Tyr Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro 
                485                 490                 495     


Ala Arg Ala Leu Leu Ala Ser Trp Ala Ala Gln Asp Ser Ala Thr Leu 
            500                 505                 510         


Asp Ala Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Ile Val 
        515                 520                 525             


Glu Ser Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
    530                 535                 540     


<210>  135
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine NGFR ECD

<400>  135

Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys 
1               5                   10                  15      


Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala 
            20                  25                  30          


Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp 
        35                  40                  45              


Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly 
    50                  55                  60                  


Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys 
65                  70                  75                  80  


Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu 
                85                  90                  95      


Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln 
            100                 105                 110         


Asp Arg Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser 
        115                 120                 125             


Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu 
    130                 135                 140                 


Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu 
145                 150                 155                 160 


Cys Glu Glu 
            


<210>  136
<211>  430
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<223>  Feline NGFR

<400>  136

Met Gly Ala Gly Ala Ala Gly Arg Ala Met Asp Gly Pro Arg Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys 
            20                  25                  30          


Glu Ala Cys Pro Thr Gly Leu Phe Thr His Ser Gly Glu Cys Cys Lys 
        35                  40                  45              


Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln 
    50                  55                  60                  


Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val 
65                  70                  75                  80  


Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln 
                85                  90                  95      


Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys 
            100                 105                 110         


Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys 
        115                 120                 125             


Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Arg 
    130                 135                 140                 


Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu 
145                 150                 155                 160 


Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr 
                165                 170                 175     


Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu 
            180                 185                 190         


Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Ser Glu Gly Ser 
        195                 200                 205             


Asp Ser Thr Ala Pro Ser Thr Glu Glu Pro Glu Val Pro Pro Glu Gln 
    210                 215                 220                 


Asp Leu Ile Ala Ser Thr Val Ala Asp Val Val Thr Thr Val Met Gly 
225                 230                 235                 240 


Ser Ser Gln Pro Val Val Thr Arg Gly Thr Ala Asp Asn Leu Ile Pro 
                245                 250                 255     


Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr 
            260                 265                 270         


Ile Ala Phe Lys Arg Trp Asn Ser Cys Lys Gln Asp Lys Gln Gly Ala 
        275                 280                 285             


Asn Ser Arg Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu 
    290                 295                 300                 


His Ser Asp Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln 
305                 310                 315                 320 


Gln Ser His Thr Gln Thr Ala Ala Gly Gln Ala Leu Lys Gly Asp Gly 
                325                 330                 335     


Gly Leu Tyr Ser Ser Leu Pro Ser Ala Lys Arg Glu Glu Val Glu Lys 
            340                 345                 350         


Leu Leu Asn Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu 
        355                 360                 365             


Leu Gly Tyr Gln Pro Glu His Ile Asp Ser Phe Thr Arg Glu Ala Cys 
    370                 375                 380                 


Pro Ala Arg Ala Leu Leu Ala Ser Trp Ala Ala Gln Asp Ser Ala Thr 
385                 390                 395                 400 


Leu Asp Ala Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Ile 
                405                 410                 415     


Val Glu Ser Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425                 430 


<210>  137
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline NGFR ECD

<400>  137

Ala Lys Glu Ala Cys Pro Thr Gly Leu Phe Thr His Ser Gly Glu Cys 
1               5                   10                  15      


Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala 
            20                  25                  30          


Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp 
        35                  40                  45              


Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly 
    50                  55                  60                  


Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys 
65                  70                  75                  80  


Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu 
                85                  90                  95      


Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln 
            100                 105                 110         


Asp Arg Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser 
        115                 120                 125             


Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu 
    130                 135                 140                 


Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu 
145                 150                 155                 160 


Cys Glu Glu 
            


<210>  138
<211>  429
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<223>  Equine NGFR

<400>  138

Met Arg Ala Gly Ala Ala Asp Cys Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Val Cys Leu Leu Gly Gly Ala Lys Glu 
            20                  25                  30          


Val Cys Pro Thr Asp Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
        35                  40                  45              


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
    50                  55                  60                  


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
65                  70                  75                  80  


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
                85                  90                  95      


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
            100                 105                 110         


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Gln 
        115                 120                 125             


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
    130                 135                 140                 


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
145                 150                 155                 160 


Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu 
                165                 170                 175     


Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu 
            180                 185                 190         


Ile Pro Ser Arg Trp Ile Thr Arg Ala Thr Pro Pro Glu Gly Ser Asp 
        195                 200                 205             


Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Gly Pro Pro Glu Lys Asp 
    210                 215                 220                 


Leu Val Ala Ser Thr Val Ala Asp Val Val Thr Thr Val Met Gly Ser 
225                 230                 235                 240 


Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val 
                245                 250                 255     


Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile 
            260                 265                 270         


Ala Phe Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn 
        275                 280                 285             


Ser Arg Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His 
    290                 295                 300                 


Ser Asp Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln 
305                 310                 315                 320 


Pro His Thr Gln Thr Ala Ala Gly Gln Ala Leu Lys Gly Asp Gly Gly 
                325                 330                 335     


Leu Tyr Ser Ser Leu Pro Leu Ala Lys Arg Glu Glu Val Glu Lys Leu 
            340                 345                 350         


Leu Asn Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu 
        355                 360                 365             


Gly Tyr Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro 
    370                 375                 380                 


Val Arg Ala Leu Leu Ala Ser Trp Ala Ala Gln Asp Ser Ala Thr Phe 
385                 390                 395                 400 


Asp Ala Leu Leu Thr Ala Leu Arg Arg Ile Gln Arg Ala Asp Ile Val 
                405                 410                 415     


Glu Ser Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425                 


<210>  139
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine NGFR ECD

<400>  139

Ala Lys Glu Val Cys Pro Thr Asp Leu Tyr Thr His Ser Gly Glu Cys 
1               5                   10                  15      


Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala 
            20                  25                  30          


Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp 
        35                  40                  45              


Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly 
    50                  55                  60                  


Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys 
65                  70                  75                  80  


Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu 
                85                  90                  95      


Ala Cys Gln Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln 
            100                 105                 110         


Asp Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser 
        115                 120                 125             


Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu 
    130                 135                 140                 


Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu 
145                 150                 155                 160 


Cys Glu Glu 
            


<210>  140
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - canine NGFR ECD - 
       variant canine IgG-B Fc - canine TrkA ECD v3 with signal sequence
       Protein A + C1q - CD16 -

<400>  140

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His 
    130                 135                 140                 


Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln 
145                 150                 155                 160 


Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val 
                165                 170                 175     


Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr 
            180                 185                 190         


Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp 
        195                 200                 205             


Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr 
    210                 215                 220                 


Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val 
225                 230                 235                 240 


Phe Ser Cys Gln Asp Arg Gln Asn Thr Val Cys Glu Glu Cys Pro Asp 
                245                 250                 255     


Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys 
            260                 265                 270         


Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp 
        275                 280                 285             


Ala Asp Ala Glu Cys Glu Glu Arg Pro Pro Asp Cys Pro Lys Cys Pro 
    290                 295                 300                 


Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
            340                 345                 350         


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
        355                 360                 365             


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
    370                 375                 380                 


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
                405                 410                 415     


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
            420                 425                 430         


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
        435                 440                 445             


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
    450                 455                 460                 


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
                485                 490                 495     


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Ser Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu 
    530                 535                 540                 


Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro 
545                 550                 555                 560 


Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe 
                565                 570                 575     


Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His 
            580                 585                 590         


Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr 
        595                 600                 605             


Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met 
    610                 615                 620                 


Ala Ala Phe Met Asp Asn Pro 
625                 630     


<210>  141
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine NGFR ECD - canine TrkA ECD v3 
       -variant canine IgG-B Fc - canine TrkA ECD v3 with signal 
       sequence Protein A + C1q - CD16 -

<400>  141

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr 
            20                  25                  30          


Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val 
        35                  40                  45              


Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp 
    50                  55                  60                  


Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro 
65                  70                  75                  80  


Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu 
                85                  90                  95      


Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu 
            100                 105                 110         


Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly 
        115                 120                 125             


Leu Val Phe Ser Cys Gln Asp Arg Gln Asn Thr Val Cys Glu Glu Cys 
    130                 135                 140                 


Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu 
145                 150                 155                 160 


Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr 
                165                 170                 175     


Arg Trp Ala Asp Ala Glu Cys Glu Glu Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Ser Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu 
        195                 200                 205             


Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro 
    210                 215                 220                 


Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe 
225                 230                 235                 240 


Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His 
                245                 250                 255     


Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr 
            260                 265                 270         


Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met 
        275                 280                 285             


Ala Ala Phe Met Asp Asn Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro 
    290                 295                 300                 


Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
            340                 345                 350         


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
        355                 360                 365             


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
    370                 375                 380                 


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
                405                 410                 415     


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
            420                 425                 430         


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
        435                 440                 445             


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
    450                 455                 460                 


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
                485                 490                 495     


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Ser Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu 
    530                 535                 540                 


Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro 
545                 550                 555                 560 


Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe 
                565                 570                 575     


Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His 
            580                 585                 590         


Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr 
        595                 600                 605             


Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met 
    610                 615                 620                 


Ala Ala Phe Met Asp Asn Pro 
625                 630     


<210>  142
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 -variant canine IgG-B Fc 
       - canine NGFR ECD with signal sequence Protein A + C1q - CD16 -

<400>  142

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Ala 
        355                 360                 365             


Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
    370                 375                 380                 


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
385                 390                 395                 400 


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
                405                 410                 415     


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
            420                 425                 430         


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
        435                 440                 445             


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
    450                 455                 460                 


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
465                 470                 475                 480 


Arg Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
                485                 490                 495     


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
            500                 505                 510         


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
        515                 520                 525             


Glu Glu 
    530 


<210>  143
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  143

Gly Ser Gly Ser 
1               


<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  144

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  145
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  145

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  146

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  147

Gly Gly Gly Ser 
1               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  148

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  149
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  149

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  150

Gly Ser Ser Gly Ser Ser 
1               5       


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  151

Gly Ser Ser Gly Ser Ser Gly Ser Ser 
1               5                   


<210>  152
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  152

Gly Gly Ser Ser 
1               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  153

Gly Gly Ser Ser Gly Gly Ser Ser 
1               5               


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  154

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
1               5                   10      


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  155

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  156

Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  157

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
1               5                   10          


<210>  158
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary linker

<400>  158

Ser Gly Gly Gly 
1               


<210>  159
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - wildtype canine IgG-B 
       Fc Protein A+ C1q + CD16 +

<400>  159

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  160
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - wildtype canine IgG-B 
       Fc  Protein A+ C1q + CD16 +

<400>  160

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  161
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - wildtype canine IgG-B 
       Fc  Protein A+ C1q + CD16 +

<400>  161

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  162
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v2 - wildtype feline IgG2 Fc
       Protein A + C1q - CD16 -

<400>  162

Val Ser Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Ser Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys 
    130                 135                 140                 


Thr Gly Glu Gly Pro Lys Cys Pro Val Pro Glu Ile Pro Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp 
            180                 185                 190         


Ser Asn Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr 
        195                 200                 205             


Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu 
225                 230                 235                 240 


Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val 
            260                 265                 270         


Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr 
        275                 280                 285             


Cys Leu Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro 
305                 310                 315                 320 


Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val 
                325                 330                 335     


Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser 
            340                 345                 350         


His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  163
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v3 - wildtype feline IgG2 Fc
       Protein A + C1q - CD16 -

<400>  163

Val Ser Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys 
            100                 105                 110         


Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys Cys Pro 
        115                 120                 125             


Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys 
    130                 135                 140                 


Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu 
145                 150                 155                 160 


Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr Trp Phe 
                165                 170                 175     


Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg Glu Glu 
            180                 185                 190         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His 
        195                 200                 205             


Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys 
    210                 215                 220                 


Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln 
225                 230                 235                 240 


Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu Glu Leu 
                245                 250                 255     


Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe His Pro 
            260                 265                 270         


Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu 
        275                 280                 285             


Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr 
    290                 295                 300                 


Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly 
305                 310                 315                 320 


Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His 
                325                 330                 335     


Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
            340                 345         


<210>  164
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline TrkA ECD v4 - wildtype feline IgG2 Fc
       Protein A + C1q - CD16 -

<400>  164

Phe Pro Ala Ser Val Gln Leu His Ala Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Ser Val Leu Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Thr Ala 
            100                 105                 110         


Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys Cys Pro Val Pro 
        115                 120                 125             


Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
    130                 135                 140                 


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
145                 150                 155                 160 


Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr Trp Phe Val Asp 
                165                 170                 175     


Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe 
            180                 185                 190         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
        195                 200                 205             


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
    210                 215                 220                 


Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
225                 230                 235                 240 


Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu 
                245                 250                 255     


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe His Pro Pro Asp 
            260                 265                 270         


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
        275                 280                 285             


Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
    290                 295                 300                 


Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
305                 310                 315                 320 


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
                325                 330                 335     


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
            340                 345 


<210>  165
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v2 - variant equine IgG2 Fc 
       Protein A + C1q - CD16 -

<400>  165

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg Asp Pro Pro Cys 
        115                 120                 125             


Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val Pro Lys Pro 
    130                 135                 140                 


Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly Pro Ser Val 
145                 150                 155                 160 


Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                165                 170                 175     


Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln Tyr Pro Asp 
            180                 185                 190         


Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His Ser Ala Ile 
        195                 200                 205             


Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    210                 215                 220                 


Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys 
225                 230                 235                 240 


Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser Arg Ala Ile 
                245                 250                 255     


Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr Val Leu Pro 
            260                 265                 270         


Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val Thr Cys Leu 
        275                 280                 285             


Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp Gln Ser Asn 
    290                 295                 300                 


Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu 
305                 310                 315                 320 


Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr 
                325                 330                 335     


Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly 
        355                 360                 365             


Lys 
    


<210>  166
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v3 - variant equine IgG2 Fc 
       Protein A + C1q - CD16 -

<400>  166

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile 
            100                 105                 110         


Pro Ile Pro Ser Val Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser 
        115                 120                 125             


Lys Phe Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys 
    130                 135                 140                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val 
145                 150                 155                 160 


Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp 
                165                 170                 175     


Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe 
            180                 185                 190         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp 
        195                 200                 205             


Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val 
    210                 215                 220                 


Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg 
225                 230                 235                 240 


Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys 
                245                 250                 255     


Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp 
            260                 265                 270         


Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys 
        275                 280                 285             


Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu 
    290                 295                 300                 


Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser 
305                 310                 315                 320 


Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys 
                325                 330                 335     


Thr Asp Ile Ser Glu Ser Leu Gly Lys 
            340                 345 


<210>  167
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v4 - variant equine IgG2 Fc 
       Protein A + C1q - CD16 -

<400>  167

Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile 
            100                 105                 110         


Pro Ser Val Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu 
145                 150                 155                 160 


Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr 
                165                 170                 175     


Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu 
        195                 200                 205             


Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln 
    210                 215                 220                 


Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro 
225                 230                 235                 240 


Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys 
                245                 250                 255     


Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser 
            260                 265                 270         


Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser 
        275                 280                 285             


Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser 
    290                 295                 300                 


Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr 
305                 310                 315                 320 


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp 
                325                 330                 335     


Ile Ser Glu Ser Leu Gly Lys 
            340             


<210>  168
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A+ C1q - CD16 -

<400>  168

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  169
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A+ C1q - CD16 -

<400>  169

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  170
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A+ C1q - CD16 -

<400>  170

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  171
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-A Fc
       C1q - Protein A +

<400>  171

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro 
    130                 135                 140                 


Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser 
            180                 185                 190         


Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg 
        195                 200                 205             


Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
    210                 215                 220                 


Gly His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn 
225                 230                 235                 240 


His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
                245                 250                 255     


Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys 
            260                 265                 270         


Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp 
        275                 280                 285             


Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln 
    290                 295                 300                 


Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp 
305                 310                 315                 320 


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp 
                325                 330                 335     


Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His 
            340                 345                 350         


Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360                 365     


<210>  172
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-A Fc
       C1q - Protein A +

<400>  172

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe Asn 
            100                 105                 110         


Glu Cys Arg Cys Thr Asp Thr Pro Cys Pro Val Pro Glu Pro Leu Gly 
        115                 120                 125             


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
    130                 135                 140                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
145                 150                 155                 160 


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
                165                 170                 175     


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
            180                 185                 190         


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr Gly 
        195                 200                 205             


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
    210                 215                 220                 


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
225                 230                 235                 240 


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
                245                 250                 255     


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
            260                 265                 270         


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
        275                 280                 285             


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
    290                 295                 300                 


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
305                 310                 315                 320 


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser Leu 
                325                 330                 335     


Ser His Ser Pro Gly Lys 
            340         


<210>  173
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-A Fc
       C1q - Protein A +

<400>  173

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe Asn Glu Cys 
            100                 105                 110         


Arg Cys Thr Asp Thr Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp 
145                 150                 155                 160 


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr 
                165                 170                 175     


Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr Gly Lys Glu 
        195                 200                 205             


Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg 
    210                 215                 220                 


Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val 
225                 230                 235                 240 


Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile 
                245                 250                 255     


Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp 
            260                 265                 270         


Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro 
        275                 280                 285             


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
    290                 295                 300                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val 
305                 310                 315                 320 


Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser Leu Ser His 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210>  174
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-D Fc
       C1q - Protein A +

<400>  174

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser 
    130                 135                 140                 


Pro Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile 
                165                 170                 175     


Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile 
            180                 185                 190         


Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro 
        195                 200                 205             


Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro 
    210                 215                 220                 


Ile Gly His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val 
225                 230                 235                 240 


Asn His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala 
                245                 250                 255     


Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro 
            260                 265                 270         


Lys Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys 
        275                 280                 285             


Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu 
305                 310                 315                 320 


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
                325                 330                 335     


Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu 
            340                 345                 350         


His Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360                 365         


<210>  175
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-D Fc
       C1q - Protein A +

<400>  175

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys 
            100                 105                 110         


Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu 
        115                 120                 125             


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 


Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly 
145                 150                 155                 160 


Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu 
                165                 170                 175     


Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr 
            180                 185                 190         


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr 
        195                 200                 205             


Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro 
    210                 215                 220                 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
225                 230                 235                 240 


Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr 
                245                 250                 255     


Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp 
            260                 265                 270         


Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His 
        275                 280                 285             


Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
    290                 295                 300                 


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr 
305                 310                 315                 320 


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser 
                325                 330                 335     


Leu Ser His Ser Pro Gly Lys 
            340             


<210>  176
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-D Fc
       C1q - Protein A +

<400>  176

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Glu Ser 
            100                 105                 110         


Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
    130                 135                 140                 


Ala Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu 
145                 150                 155                 160 


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His 
                165                 170                 175     


Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg 
            180                 185                 190         


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Thr Gly Lys 
        195                 200                 205             


Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu 
    210                 215                 220                 


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
225                 230                 235                 240 


Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu 
            260                 265                 270         


Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr 
        275                 280                 285             


Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Asp Leu Ser Leu Ser 
                325                 330                 335     


His Ser Pro Gly Lys 
            340     


<210>  177
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v2 - variant equine  IgG2 
       with IgG1 hinge C1q - Protein A +

<400>  177

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Arg Asp Asp Met Ser 
        115                 120                 125             


Lys Cys Pro Lys Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln Tyr Pro Asp 
                165                 170                 175     


Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His Ser Ala Ile 
            180                 185                 190         


Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys Glu Phe Lys 
    210                 215                 220                 


Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser Arg Ala Ile 
225                 230                 235                 240 


Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr Val Leu Pro 
                245                 250                 255     


Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val Thr Cys Leu 
            260                 265                 270         


Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp Gln Ser Asn 
        275                 280                 285             


Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu 
    290                 295                 300                 


Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Leu Glu Thr 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile Ser Glu Ser Leu Gly 
            340                 345                 350         


Lys 
    


<210>  178
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v3 - variant equine  IgG2 
       with IgG1 hinge  C1q - Protein A +

<400>  178

Val Ser Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Asp Met Ser Lys Cys Pro Lys Cys Pro Ala Pro 
            100                 105                 110         


Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val 
    130                 135                 140                 


Asn Leu Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp 
145                 150                 155                 160 


Asn Thr Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp 
            180                 185                 190         


Trp Leu Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val 
        195                 200                 205             


Pro Gln Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg 
    210                 215                 220                 


Val Pro Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys 
225                 230                 235                 240 


Ser Lys Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp 
                245                 250                 255     


Ile Ser Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys 
            260                 265                 270         


Tyr Ser Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser 
    290                 295                 300                 


Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys 
305                 310                 315                 320 


Thr Asp Ile Ser Glu Ser Leu Gly Lys 
                325                 


<210>  179
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine TrkA ECD v4 - variant equine  IgG2 
       with IgG1 hinge  C1q - Protein A +

<400>  179

Phe Pro Ala Ser Val His Leu Gln Thr Ala Val Glu Gln His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Thr Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Ser Ala Ala Asn Glu Thr Met Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Thr Asn Pro Tyr Gly Gln Asp Ser Ala Ser Val Met Val Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Asp Met Ser Lys Cys Pro Lys Cys Pro Ala Pro Glu Leu 
            100                 105                 110         


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu 
    130                 135                 140                 


Ser Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr 
145                 150                 155                 160 


Glu Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser 
                165                 170                 175     


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu 
            180                 185                 190         


Ser Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln 
        195                 200                 205             


Pro Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro 
    210                 215                 220                 


Gln Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys 
225                 230                 235                 240 


Val Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser 
                245                 250                 255     


Val Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser 
            260                 265                 270         


Thr Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr 
    290                 295                 300                 


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp 
305                 310                 315                 320 


Ile Ser Glu Ser Leu Gly Lys 
                325         


<210>  180
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Extra disulfide Protein A+ C1q - CD16 -

<400>  180

Val Ser Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  181
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Extra disulfide Protein A+ C1q - CD16 -

<400>  181

Val Ser Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  182
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Extra disulfide Protein A+ C1q - CD16 -

<400>  182

Phe Pro Ala Ser Cys Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Cys Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  183
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 -

<400>  183

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  184
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 -

<400>  184

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  185
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 -

<400>  185

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  186
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A + C1q - CD16 -

<400>  186

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  187
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A + C1q - CD16 -

<400>  187

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  188
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A + C1q - CD16 -

<400>  188

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  189
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 x2 - variant canine IgG-B
       Fc Protein A + C1q - CD16 -

<400>  189

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Val Ser 
            100                 105                 110         


Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
        115                 120                 125             


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
    130                 135                 140                 


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
145                 150                 155                 160 


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
                165                 170                 175     


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
            180                 185                 190         


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
        195                 200                 205             


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
    210                 215                 220                 


Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
305                 310                 315                 320 


Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
        355                 360                 365             


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
    370                 375                 380                 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
385                 390                 395                 400 


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445             


<210>  190
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc - canine TrkA ECD v3
       Protein A + C1q - CD16 -

<400>  190

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn 
            100                 105                 110         


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
        115                 120                 125             


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
145                 150                 155                 160 


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
                165                 170                 175     


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
            180                 185                 190         


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala 
                245                 250                 255     


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
            260                 265                 270         


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
        275                 280                 285             


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
    290                 295                 300                 


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
305                 310                 315                 320 


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
                325                 330                 335     


Val Met Ala Ala Phe Met Asp Asn Pro 
            340                 345 


<210>  191
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       - canine TrkA ECD v3 Protein A + C1q - CD16 -

<400>  191

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys Ser Gly Gly Gly Ser Gly Gly Val Ser Phe Pro Ala Ser Val 
            340                 345                 350         


Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser 
        355                 360                 365             


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
    370                 375                 380                 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val 
385                 390                 395                 400 


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
                405                 410                 415     


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly 
            420                 425                 430         


Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro 
        435                 440                 445     


<210>  192
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - canine NGFR ECD - 
       variant canine IgG-B Fc - canine TrkA ECD v3 Protein A + C1q - 
       CD16 -

<400>  192

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Lys 
            100                 105                 110         


Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys 
        115                 120                 125             


Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln 
    130                 135                 140                 


Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val 
145                 150                 155                 160 


Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln 
                165                 170                 175     


Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys 
            180                 185                 190         


Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys 
        195                 200                 205             


Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Arg 
    210                 215                 220                 


Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu 
225                 230                 235                 240 


Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr 
                245                 250                 255     


Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu 
            260                 265                 270         


Glu Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
                325                 330                 335     


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
        355                 360                 365             


Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
            420                 425                 430         


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
        435                 440                 445             


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
                485                 490                 495     


His Ser Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Val Ser Phe Pro 
            500                 505                 510         


Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile 
        515                 520                 525             


Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe 
    530                 535                 540                 


Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu 
545                 550                 555                 560 


Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn 
                565                 570                 575     


Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn 
            580                 585                 590         


Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn 
        595                 600                 605             


Pro 
    


<210>  193
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine NGFR ECD - canine TrkA ECD v3 
       -variant canine IgG-B Fc - canine TrkA ECD v3 Protein A + C1q - 
       CD16 -

<400>  193

Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys 
1               5                   10                  15      


Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala 
            20                  25                  30          


Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp 
        35                  40                  45              


Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly 
    50                  55                  60                  


Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys 
65                  70                  75                  80  


Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu 
                85                  90                  95      


Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln 
            100                 105                 110         


Asp Arg Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser 
        115                 120                 125             


Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu 
    130                 135                 140                 


Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu 
145                 150                 155                 160 


Cys Glu Glu Ser Gly Gly Gly Ser Gly Gly Gly Ser Val Ser Phe Pro 
                165                 170                 175     


Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile 
            180                 185                 190         


Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe 
        195                 200                 205             


Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu 
    210                 215                 220                 


Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn 
225                 230                 235                 240 


Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn 
                245                 250                 255     


Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn 
            260                 265                 270         


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
                325                 330                 335     


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
        355                 360                 365             


Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
            420                 425                 430         


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
        435                 440                 445             


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
                485                 490                 495     


His Ser Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Val Ser Phe Pro 
            500                 505                 510         


Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp Cys Ile 
        515                 520                 525             


Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe 
    530                 535                 540                 


Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu 
545                 550                 555                 560 


Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn 
                565                 570                 575     


Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn 
            580                 585                 590         


Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met Asp Asn 
        595                 600                 605             


Pro 
    


<210>  194
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 -variant canine IgG-B Fc 
       - canine NGFR ECD Protein A + C1q - CD16 -

<400>  194

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Gly Arg Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys Ser Gly Gly Gly Ser Gly Gly Ala Lys Glu Ala Cys Pro Thr 
            340                 345                 350         


Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly 
        355                 360                 365             


Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro 
    370                 375                 380                 


Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro 
385                 390                 395                 400 


Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro 
                405                 410                 415     


Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr 
            420                 425                 430         


Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala 
        435                 440                 445             


Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Arg Gln Asn Thr Val Cys 
    450                 455                 460                 


Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp 
465                 470                 475                 480 


Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg 
                485                 490                 495     


Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu 
            500                 505             


<210>  195
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine FcRn with poly-His

<400>  195

Met Gly Val Pro Arg Pro Arg Ser Trp Gly Leu Gly Phe Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Thr Leu Arg Ala Ala Asp Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ala Pro Pro Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Ala Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Asn Leu 
    50                  55                  60                  


Arg Ala Gln Ala Glu Pro Tyr Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Thr Lys Glu Gly 
                85                  90                  95      


Leu Phe Leu Glu Ala Leu Lys Ala Leu Gly Asp Gly Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Val Ala Lys Phe Ala Leu Asn Gly Glu Asp Phe Met Thr Phe Asp 
    130                 135                 140                 


Pro Lys Leu Gly Thr Trp Asn Gly Asp Trp Pro Glu Thr Glu Thr Val 
145                 150                 155                 160 


Ser Lys Arg Trp Met Gln Gln Ala Gly Ala Val Ser Lys Glu Arg Thr 
                165                 170                 175     


Phe Leu Leu Tyr Ser Cys Pro Gln Arg Leu Leu Gly His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Gly Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Gly Glu Gly Asp Phe Gly Pro Asn Gly Asp Gly Ser 
                245                 250                 255     


Phe His Ala Trp Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Arg Cys Leu Val Gln His Ala Gly Leu Pro Gln Pro Leu Thr Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Gly Ser His His His His His 
    290                 295                 300                 


His 
305 


<210>  196
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine B2M

<400>  196

Met Ala Pro Arg Pro Ala Leu Ala Thr Ala Gly Phe Leu Ala Leu Leu 
1               5                   10                  15      


Leu Ile Leu Leu Ala Ala Cys Arg Leu Asp Ala Val Gln His Pro Pro 
            20                  25                  30          


Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Pro Asn 
        35                  40                  45              


Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Pro Glu Ile Glu Ile 
    50                  55                  60                  


Asp Leu Leu Lys Asn Gly Lys Glu Met Lys Ala Glu Gln Thr Asp Leu 
65                  70                  75                  80  


Ser Phe Ser Lys Asp Trp Thr Phe Tyr Leu Leu Val His Thr Glu Phe 
                85                  90                  95      


Thr Pro Asn Glu Gln Asp Glu Phe Ser Cys Arg Val Lys His Val Thr 
            100                 105                 110         


Leu Ser Glu Pro Gln Ile Val Lys Trp Asp Arg Asp Asn 
        115                 120                 125 


<210>  197
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q +  
       CD16 +   L(23)F (F00)

<400>  197

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  198
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc   Protein A + C1q + 
       CD16 +   L(23)Y (Y00)

<400>  198

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  199
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc (F00; Protein A+; 
       C1q-; CD16 -)  I(21)T; R(23)F; T(25)A; E(80)G; T(205)A; Q(207)H

<400>  199

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  200
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc (Protein A+; C1q+; 
       CD16 +)  V2A; P5M; I21T; R23L; T25A; L35V; G38D; R39P; Q65E; 
       E80G; R93K; H96N; I97K; D98A; T205A; Q207H

<400>  200

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  201
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc (F00; Protein A+; 
       C1q-; CD16 -)  I(21)T; R(23)F; T(25)A; E(80)G; Q(205)A; Q(207)H

<400>  201

Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Ile Thr 
            20                  25                  30          


Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser 
        35                  40                  45              


Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg 
    50                  55                  60                  


Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
65                  70                  75                  80  


Gly His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn 
                85                  90                  95      


His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 105                 110         


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys 
        115                 120                 125             


Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp 
    130                 135                 140                 


Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp 
                165                 170                 175     


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220         


<210>  202
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc (Protein A+; C1q+; 
       CD16 +)  V2A; S5M; I21T; R23L; T25A; L35V; G38D; R39P; Q65E; 
       E80G; R93K; H96N; I97K; G98A; Q207H

<400>  202

Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr 
            20                  25                  30          


Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser 
        35                  40                  45              


Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg 
    50                  55                  60                  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
65                  70                  75                  80  


Gly His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Lys Val Asn 
                85                  90                  95      


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 105                 110         


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys 
        115                 120                 125             


Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp 
    130                 135                 140                 


Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp 
                165                 170                 175     


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220         


<210>  203
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc (0Y0)   Protein A + 
       C1q +  CD16 +   Q(82)Y (0Y0)

<400>  203

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  204
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc (0YH)  Gln82Tyr 
       Asn207His

<400>  204

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His His His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  205
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc (0YY)  Gln82Tyr 
       Asn207Tyr

<400>  205

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Tyr His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  206
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc (00Y)  Asn207Tyr

<400>  206

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Tyr His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  207
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc (YTE)  Leu23Tyr 
       Ala25Thr Thr27Glu

<400>  207

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  208
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q - 
       CD16 - K(93)R K(97)I A(98)G  L(23)F (F00)

<400>  208

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  209
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q - 
       CD16 - K(93)R K(97)I A(98)G  L(23)Y (Y00)

<400>  209

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  210
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q - 
       CD16 - K(93)R K(97)I A(98)G  Q(82)Y (0Y0)

<400>  210

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  211
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  211

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  212
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  212

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  213
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  213

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  214
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  214

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  215
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  215

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  216
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)F (F00)

<400>  216

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  217
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  217

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  218
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  218

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  219
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  219

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  220
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  220

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  221
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  221

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  222
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   L(23)Y (Y00)

<400>  222

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  223
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  223

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  224
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  224

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  225
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  225

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  226
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  226

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  227
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  227

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  228
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A + C1q +  CD16 +   Q(82)Y (0Y0)

<400>  228

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  229
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)F (F00)

<400>  229

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  230
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)F (F00)

<400>  230

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  231
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)F (F00)

<400>  231

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  232
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)F (F00)

<400>  232

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  233
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)F (F00)

<400>  233

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Phe Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  234
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)F (F00)

<400>  234

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Phe Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  235
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)Y (Y00)

<400>  235

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  236
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)Y (Y00)

<400>  236

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  237
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)Y (Y00)

<400>  237

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  238
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)Y (Y00)

<400>  238

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  239
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  L(23)Y (Y00)

<400>  239

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Tyr Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  240
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  L(23)F (Y00)

<400>  240

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  241
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  Q(82)Y (0Y0)

<400>  241

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro 
        115                 120                 125             


Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr Asn Ser Thr 
    130                 135                 140                 


Ser Gly Asp Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
145                 150                 155                 160 


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
        195                 200                 205             


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
    210                 215                 220                 


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
                245                 250                 255     


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
            260                 265                 270         


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
    290                 295                 300                 


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
305                 310                 315                 320 


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
                325                 330                 335     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    370                 375                 380                 


<210>  242
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v2 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  Q(82)Y (0Y0)

<400>  242

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val 
            100                 105                 110         


Ser Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
    130                 135                 140                 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
            180                 185                 190         


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
        195                 200                 205             


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr 
    210                 215                 220                 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly 
225                 230                 235                 240 


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
                245                 250                 255     


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
            260                 265                 270         


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
        275                 280                 285             


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
                325                 330                 335     


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
        355                 360         


<210>  243
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  Q(82)Y (0Y0)

<400>  243

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Val Ser Phe Pro Ala Ser Val Gln Leu His 
            20                  25                  30          


Glu Ala Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly 
        35                  40                  45              


Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn 
    50                  55                  60                  


Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu 
65                  70                  75                  80  


Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn 
                85                  90                  95      


Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala 
            100                 105                 110         


Ala Phe Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
    130                 135                 140                 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
            180                 185                 190         


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        195                 200                 205             


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp 
    210                 215                 220                 


Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro 
225                 230                 235                 240 


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
                245                 250                 255     


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
            260                 265                 270         


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
        275                 280                 285             


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
                325                 330                 335     


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
            340                 345                 350         


Ser Leu Ser His Ser Pro Gly Lys 
        355                 360 


<210>  244
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v3 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  Q(82)Y (0Y0)

<400>  244

Val Ser Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His 
1               5                   10                  15      


His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu 
            20                  25                  30          


Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe 
        35                  40                  45              


Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys 
    50                  55                  60                  


Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu 
65                  70                  75                  80  


Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala 
                85                  90                  95      


Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro 
            100                 105                 110         


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
    130                 135                 140                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
145                 150                 155                 160 


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
                165                 170                 175     


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
            180                 185                 190         


Ser Val Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe 
        195                 200                 205             


Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
225                 230                 235                 240 


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
            260                 265                 270         


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
        275                 280                 285             


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  245
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       with signal sequence Protein A +  C1q - CD16 - K(93)R K(97)I 
       A(98)G  Q(82)Y (0Y0)

<400>  245

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Phe Pro Ala Ser Val Gln Leu His Glu Ala 
            20                  25                  30          


Val Glu Leu His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro 
        35                  40                  45              


Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr 
    50                  55                  60                  


Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Val Ala Asn Glu Thr Val 
65                  70                  75                  80  


Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly 
                85                  90                  95      


Asn Tyr Thr Leu Leu Ala Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe 
            100                 105                 110         


Val Met Ala Ala Phe Met Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
                165                 170                 175     


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
            180                 185                 190         


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Tyr Asp Trp Leu Lys 
    210                 215                 220                 


Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Ile Gly Leu Pro Ser Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
        275                 280                 285             


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
    290                 295                 300                 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
                325                 330                 335     


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
            340                 345                 350         


Ser His Ser Pro Gly Lys 
        355             


<210>  246
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine TrkA ECD v4 - variant canine IgG-B Fc
       Protein A +  C1q - CD16 - K(93)R K(97)I A(98)G  Q(82)Y (0Y0)

<400>  246

Phe Pro Ala Ser Val Gln Leu His Glu Ala Val Glu Leu His His Trp 
1               5                   10                  15      


Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp 
            20                  25                  30          


Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu 
        35                  40                  45              


Phe Leu Glu Pro Val Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg 
    50                  55                  60                  


Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala 
65                  70                  75                  80  


Ala Asn Pro Ser Gly Arg Ala Ala Ala Phe Val Met Ala Ala Phe Met 
                85                  90                  95      


Asp Asn Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Tyr Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Arg Val Asn Asn Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


