                         SEQUENCE LISTING

<110>  THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF
        ARIZONA
       Kuhns, Michael
 
<120>  SURROGATE CO-RECEPTORS FOR T CELLS AND METHODS OF USE

<130>  UA16-189 et al., UNIA 19.03 PCT

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Met Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Val Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  2
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Thr Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Phe Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Tyr Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Trp Gln Thr Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg His Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  3
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Asn Leu Arg Lys Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Trp Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu His 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Met Ala Val Val Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Ser Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Ala Cys Lys Ala 
        355                 360                 365     


<210>  4
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  5
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  6
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  7
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  8
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  9
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Pro Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  10
<211>  250
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ser Arg Ala Leu Ile Leu Gly Val Leu Ala Leu Thr Thr Met Leu 
1               5                   10                  15      


Ser Leu Cys Gly Gly Glu Asp Tyr Ile Glu Ala Asp His Val Ala Phe 
            20                  25                  30          


Tyr Gly Ile Ser Val Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr 
        35                  40                  45              


Phe Glu Phe Asp Gly Asp Glu Leu Phe Tyr Val Asp Leu Asp Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Met Leu Pro Glu Phe Gly Gln Leu Thr Ser Phe Asp 
65                  70                  75                  80  


Pro Gln Gly Gly Leu Gln Glu Ile Ala Thr Gly Lys Tyr Asn Leu Glu 
                85                  90                  95      


Ile Leu Ile Lys Asp Ser Asn Phe Thr Pro Ala Ala Asn Glu Ala Pro 
            100                 105                 110         


Gln Ala Thr Val Phe Pro Lys Ser Pro Val Leu Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Phe Val Asp Asn Ile Phe Pro Pro Val Ile Asn Ile 
    130                 135                 140                 


Thr Trp Leu Arg Asn Ser Lys Ser Val Thr Asp Gly Val Tyr Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Val Asn Arg Asp His Ser Phe His Lys Leu Ser Tyr Leu 
                165                 170                 175     


Thr Phe Ile Pro Ser Asp Asp Asp Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Glu Glu Pro Val Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Ile Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Ile Phe Ile Ile Gln 
225                 230                 235                 240 


Gly Leu Arg Ser Gly Gly Thr Ser Arg His 
                245                 250 


<210>  11
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Gln Arg Thr Leu Phe Leu Leu Leu Ala Ala Ala Leu Thr Met 
1               5                   10                  15      


Ile Glu Thr Arg Ala Gly Pro His Ser Met Arg Tyr Phe Glu Thr Ala 
            20                  25                  30          


Val Phe Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asn Thr Gln Phe Val Ser Phe Asp Ser Asp Ala Glu Asn Pro 
    50                  55                  60                  


Arg Ser Glu Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr 
65                  70                  75                  80  


Trp Glu Arg Glu Thr Gln Ile Ala Lys Asp Asn Glu Gln Ser Phe Gly 
                85                  90                  95      


Trp Ser Leu Arg Asn Leu Ile His Tyr Tyr Asn Gln Ser Lys Gly Gly 
            100                 105                 110         


Phe His Thr Phe Gln Arg Leu Ser Gly Cys Asp Met Gly Leu Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr Leu Gln Phe Ala Tyr Asp Gly Arg Asp Tyr 
    130                 135                 140                 


Ile Thr Leu Asn Glu Asp Leu Lys Thr Trp Met Ala Ala Asp Leu Val 
145                 150                 155                 160 


Ala Leu Ile Thr Arg Arg Lys Trp Glu Gln Ala Gly Ala Ala Glu Leu 
                165                 170                 175     


Tyr Lys Phe Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Leu Gly Asn Glu Thr Leu Leu Arg Thr Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Thr His His Pro Arg Pro Ala Gly Asp Val Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu 
225                 230                 235                 240 


Asn Gly Glu Glu Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu 
            260                 265                 270         


Gly Lys Glu Gln Asn Tyr Thr Cys His Val Tyr His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Leu Thr Leu Arg Trp Glu Pro Pro Pro Ser Thr Gly Ser Asn 
    290                 295                 300                 


Met Val Asn Ile Ala Val Leu Val Val Leu Gly Ala Val Ile Ile Ile 
305                 310                 315                 320 


Glu Ala Met Val Ala Phe Val Leu Lys Ser Ser Arg Lys Ile Ala Ile 
                325                 330                 335     


Leu Pro Gly Pro Ala Gly Thr Lys Gly Ser Ser Ala Ser 
            340                 345                 


<210>  12
<211>  350
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Pro Cys Thr Leu Leu Leu Leu Leu Ala Ala Ala Leu Ala Pro 
1               5                   10                  15      


Thr Gln Thr Arg Ala Ala Arg Ala Ala Ala Arg Gly Pro Val Arg Arg 
            20                  25                  30          


Ser Gly Ser His Arg Ala Pro Pro Pro Gly Pro His Ser Leu Ser Asp 
        35                  40                  45              


Ala Asp Asn Pro Arg Phe Glu Pro Arg Ala Pro Trp Met Glu Gln Glu 
    50                  55                  60                  


Gly Pro Glu Tyr Trp Glu Glu Gln Thr Gln Arg Ala Lys Ser Asp Glu 
65                  70                  75                  80  


Gln Trp Phe Arg Val Ser Leu Arg Thr Ala Gln Arg Tyr Tyr Asn Gln 
                85                  90                  95      


Ser Lys Gly Gly Ser His Thr Phe Gln Arg Met Phe Gly Cys Asp Val 
            100                 105                 110         


Gly Ser Asp Trp Arg Leu Leu Arg Gly Tyr Gln Gln Phe Ala Tyr Asp 
        115                 120                 125             


Gly Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Thr Ala 
    130                 135                 140                 


Ala Asp Thr Ala Ala Leu Ile Thr Arg Arg Lys Trp Glu Gln Ala Gly 
145                 150                 155                 160 


Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp 
                165                 170                 175     


Leu Arg Arg Tyr Leu Glu Leu Gly Asn Glu Thr Leu Leu Arg Thr Asp 
            180                 185                 190         


Ser Pro Lys Ala His Val Thr Tyr His Pro Arg Ser Gln Val Asp Val 
        195                 200                 205             


Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu 
    210                 215                 220                 


Thr Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val 
225                 230                 235                 240 


Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val 
                245                 250                 255     


Val Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys His Val His His 
            260                 265                 270         


Lys Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Lys Leu Pro Pro Pro 
        275                 280                 285             


Thr Val Ser Asn Thr Val Ile Ile Ala Val Leu Val Val Leu Gly Ala 
    290                 295                 300                 


Ala Ile Val Thr Gly Ala Val Val Ala Phe Val Met Lys Met Arg Arg 
305                 310                 315                 320 


Asn Thr Gly Gly Lys Gly Val Asn Tyr Ala Leu Ala Pro Gly Ser Gln 
                325                 330                 335     


Thr Ser Asp Leu Ser Leu Pro Asp Gly Lys Val Met Val His 
            340                 345                 350 


<210>  13
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  13

Met Val Trp Leu Pro Arg Val Pro Cys Val Ala Ala Val Ile Leu Leu 
1               5                   10                  15      


Leu Thr Val Leu Ser Pro Pro Met Ala Leu Val Arg Asp Ser Arg Pro 
            20                  25                  30          


Trp Phe Leu Glu Tyr Cys Lys Ser Glu Cys His Phe Tyr Asn Gly Thr 
        35                  40                  45              


Gln Arg Val Arg Leu Leu Glu Arg Tyr Phe Tyr Asn Leu Glu Glu Asn 
    50                  55                  60                  


Leu Arg Phe Asp Ser Asp Val Gly Glu Phe His Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Ala Glu Asn Trp Asn Ser Gln Pro Glu Phe Leu Glu 
                85                  90                  95      


Gln Lys Arg Ala Glu Val Asp Thr Val Cys Arg His Asn Tyr Glu Ile 
            100                 105                 110         


Ser Asp Lys Phe Leu Val Arg Arg Arg Val Glu Pro Thr Val Thr Val 
        115                 120                 125             


Tyr Pro Thr Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Ser Asp Phe Tyr Pro Gly Asn Ile Glu Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Gly Lys Glu Glu Lys Thr Gly Ile Val Ser Thr Gly Leu Val Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro 
            180                 185                 190         


Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Thr 
        195                 200                 205             


Asp Pro Val Thr Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn 
    210                 215                 220                 


Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu Phe Leu 
225                 230                 235                 240 


Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly 
                245                 250                 255     


Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 


<210>  14
<211>  255
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Thr Ile Gly Ala Leu Val Leu Arg Phe Phe Phe Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ser Gln Lys Ser Trp Ala Ile Lys Glu Glu His Thr Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Leu Pro Asp Lys Arg Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Ile Glu Lys Ser 
    50                  55                  60                  


Glu Thr Ile Trp Arg Leu Glu Glu Phe Ala Lys Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Asp 
                85                  90                  95      


Val Met Lys Glu Arg Ser Asn Asn Thr Pro Asp Ala Asn Val Ala Pro 
            100                 105                 110         


Glu Val Thr Val Leu Ser Arg Ser Pro Val Asn Leu Gly Glu Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Phe Ile Asp Lys Phe Ser Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Arg Pro Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Asp Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Thr Asp Asp Phe Tyr Asp Cys Glu Val Asp His 
            180                 185                 190         


Trp Gly Leu Glu Glu Pro Leu Arg Lys His Trp Glu Phe Glu Glu Lys 
        195                 200                 205             


Thr Leu Leu Pro Glu Thr Lys Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Phe Val Gly Leu Val Gly Ile Val Val Gly Ile Ile Leu Ile Met Lys 
225                 230                 235                 240 


Gly Ile Lys Lys Arg Asn Val Val Glu Arg Arg Gln Gly Ala Leu 
                245                 250                 255 


<210>  15
<211>  263
<212>  PRT
<213>  Mus musculus

<400>  15

Met Trp Leu Pro Arg Val Pro Cys Val Ala Ala Val Ile Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Ser Pro Pro Val Ala Leu Val Arg Asp Ser Arg Pro Trp 
            20                  25                  30          


Phe Leu Glu Tyr Cys Lys Ser Glu Cys His Phe Tyr Asn Gly Thr Gln 
        35                  40                  45              


Arg Val Arg Leu Leu Val Arg Tyr Phe Tyr Asn Leu Glu Glu Asn Leu 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu Gly 
65                  70                  75                  80  


Arg Pro Asp Ala Glu Asn Trp Asn Ser Gln Pro Glu Phe Leu Glu Gln 
                85                  90                  95      


Lys Arg Ala Glu Val Asp Thr Val Cys Arg His Asn Tyr Glu Ile Phe 
            100                 105                 110         


Asp Asn Phe Leu Val Pro Arg Arg Val Glu Pro Thr Val Thr Val Tyr 
        115                 120                 125             


Pro Thr Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys Ser 
    130                 135                 140                 


Val Ser Asp Phe Tyr Pro Gly Asn Ile Glu Val Arg Trp Phe Arg Asn 
145                 150                 155                 160 


Gly Lys Glu Glu Lys Thr Gly Ile Val Ser Thr Gly Leu Val Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Gln 
            180                 185                 190         


Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Thr Asp 
        195                 200                 205             


Pro Val Thr Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn Lys 
    210                 215                 220                 


Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu Phe Leu Gly 
225                 230                 235                 240 


Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly Leu 
                245                 250                 255     


Gln Pro Thr Gly Leu Leu Ser 
            260             


<210>  16
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  17
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  18
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  19
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr 
1               5                   10                  15      


Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile 
            20                  25                  30          


Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val 
        35                  40                  45              


Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
    50                  55                  60                  


Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
                85                  90                  95      


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
            100                 105                 110         


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
    130                 135                 140                 


Leu Leu Thr Ala Lys Leu Phe Phe Leu 
145                 150             


<210>  20
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr 
        115                 120                 125             


Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu 
    130                 135                 140                 


Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
145                 150                 155                 160 


Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                165                 170             


<210>  21
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Thr Thr Val Asp Pro Lys Asp Ser Tyr Ser Lys Asp Ala Asn Asp Val 
        115                 120                 125             


Ile Thr Met Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr 
    130                 135                 140                 


Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
                165                 170                 175     


Leu Gly Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
            180                 185                 


<210>  22
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  22

Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
1               5                   10                  15      


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
    50                  55                  60                  


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
65                  70                  75                  80  


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
                85                  90                  95      


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
            100                 105                 110         


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
        115                 120                 125             


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135             


<210>  23
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  24
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  24

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170             


<210>  25
<211>  167
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Lys Arg Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu 
        35                  40                  45              


Lys Asn Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Thr Leu Lys 
    50                  55                  60                  


Thr Lys Gly Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg 
65                  70                  75                  80  


Ala Met Gly Lys Glu His Ser Cys Ile Val Lys His Glu Asn Asn Lys 
                85                  90                  95      


Gly Gly Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala 
            100                 105                 110         


Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Phe Gln Phe Thr 
        115                 120                 125             


Ser Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser Val 
    130                 135                 140                 


Ile Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg Arg Thr Ser Val 
145                 150                 155                 160 


Cys Gly Asn Glu Lys Lys Ser 
                165         


<210>  26
<211>  172
<212>  PRT
<213>  Mus musculus

<400>  26

Asp Lys Lys Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys 
            20                  25                  30          


Val Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu 
        35                  40                  45              


Lys Lys Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Met Leu Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg 
65                  70                  75                  80  


Ser Met Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn Asn Lys 
                85                  90                  95      


Gly Gly Ala Asp Gln Glu Ile Phe Phe Pro Thr Ile Lys Lys Val Ala 
            100                 105                 110         


Val Ser Thr Lys Pro Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu 
        115                 120                 125             


Gln Leu Gln Phe Thr Ile Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu 
    130                 135                 140                 


Leu Leu Lys Ser Val Ile Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu 
145                 150                 155                 160 


Arg Arg Thr Ser Val Cys Cys Asn Glu Lys Lys Ser 
                165                 170         


<210>  27
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  27

Pro Ser Asp Lys Arg Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile 
1               5                   10                  15      


Phe Leu Pro Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr 
            20                  25                  30          


Leu Cys Ile Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp 
        35                  40                  45              


Lys Asp Lys Asn Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Thr 
    50                  55                  60                  


Leu Lys Thr Lys Gly Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro 
65                  70                  75                  80  


Glu Arg Ser Met Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn 
                85                  90                  95      


Asn Lys Gly Gly Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys 
            100                 105                 110         


Val Ala Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Leu Gln 
        115                 120                 125             


Phe Met Ser Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys 
    130                 135                 140                 


Ser Val Ile Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg Arg Thr 
145                 150                 155                 160 


Ser Val Cys Cys Asn Glu Lys Arg Ser 
                165                 


<210>  28
<211>  190
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Lys Arg Thr Asp Ser Asp Phe Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ala Ala Glu Thr Asn Leu His Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Lys Val Ile Arg Val Tyr Trp Lys Glu 
        35                  40                  45              


Lys Asp Gly Glu Lys Ile Leu Glu Ser Gln Glu Gly Asn Thr Ile Lys 
    50                  55                  60                  


Thr Asn Asp Arg Tyr Met Lys Phe Ser Trp Leu Thr Val Thr Glu Asp 
65                  70                  75                  80  


Ser Met Ala Lys Glu His Ser Cys Ile Val Lys His Glu Asn Asn Lys 
                85                  90                  95      


Arg Gly Val Asp Gln Glu Ile Leu Phe Pro Pro Ile Gly Lys Ala Phe 
            100                 105                 110         


Thr Thr Ile Asn Val Asn Pro Arg Asp Ser Val Leu Arg His Glu Asn 
        115                 120                 125             


Val Asn Asn Ala Thr Asp Leu Glu Asp Cys Met Lys Gly Arg Lys Asp 
    130                 135                 140                 


Met Leu Gln Leu Gln Val Thr Thr Thr Tyr Ala Phe Tyr Thr Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Phe Lys Ser Met Val His Leu Ala Phe Val Val Phe Cys 
                165                 170                 175     


Leu Phe Arg Arg Ala Ala Met Ser Cys Asp Asp Gln Arg Ser 
            180                 185                 190 


<210>  29
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  29

Ala Asn Glu Arg Ala Asp Leu Ile Ala Tyr Leu Lys Gln Ala Thr Lys 
1               5                   10                  15      


<210>  30
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210>  31
<211>  213
<212>  PRT
<213>  Mus musculus

<400>  31

Met Gln Pro Trp Leu Trp Leu Val Phe Ser Met Lys Leu Ala Ala Leu 
1               5                   10                  15      


Trp Ser Ser Ser Ala Leu Ile Gln Thr Pro Ser Ser Leu Leu Val Gln 
            20                  25                  30          


Thr Asn His Thr Ala Lys Met Ser Cys Glu Val Lys Ser Ile Ser Lys 
        35                  40                  45              


Leu Thr Ser Ile Tyr Trp Leu Arg Glu Arg Gln Asp Pro Lys Asp Lys 
    50                  55                  60                  


Tyr Phe Glu Phe Leu Ala Ser Trp Ser Ser Ser Lys Gly Val Leu Tyr 
65                  70                  75                  80  


Gly Glu Ser Val Asp Lys Lys Arg Asn Ile Ile Leu Glu Ser Ser Asp 
                85                  90                  95      


Ser Arg Arg Pro Phe Leu Ser Ile Met Asn Val Lys Pro Glu Asp Ser 
            100                 105                 110         


Asp Phe Tyr Phe Cys Ala Thr Val Gly Ser Pro Lys Met Val Phe Gly 
        115                 120                 125             


Thr Gly Thr Lys Leu Thr Val Val Asp Val Leu Pro Thr Thr Ala Pro 
    130                 135                 140                 


Thr Lys Lys Thr Thr Leu Lys Met Lys Lys Lys Lys Gln Cys Pro Phe 
145                 150                 155                 160 


Pro His Pro Glu Thr Gln Lys Gly Leu Thr Cys Ser Leu Thr Thr Leu 
                165                 170                 175     


Ser Leu Leu Val Val Cys Ile Leu Leu Leu Leu Ala Phe Leu Gly Val 
            180                 185                 190         


Ala Val Tyr Phe Tyr Cys Val Arg Arg Arg Ala Arg Ile His Phe Met 
        195                 200                 205             


Lys Gln Phe His Lys 
    210             


<210>  32
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced  
       with the H57 heavy chain

<400>  32

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Thr Ser Glu Val Tyr Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Asp Leu Val Gln Pro Gly Ser Ser Leu Lys Val Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Asp Phe Trp Met Tyr Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Lys Asn Ile Pro Asn Asn 
65                  70                  75                  80  


Tyr Ala Thr Glu Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asp Ser Arg Asn Ser Ile Tyr Leu Gln Met Asn Arg Leu Arg 
            100                 105                 110         


Val Asp Asp Thr Ala Ile Tyr Tyr Cys Thr Arg Ala Gly Arg Phe Asp 
        115                 120                 125             


His Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Gly Thr 
    130                 135                 140                 


Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro 
145                 150                 155                 160 


Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg 
                165                 170                 175     


Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Pro Leu Leu Ser 
        195                 200                 205             


Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys Arg Val Cys 
    210                 215                 220                 


Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro Arg Pro Ser 
225                 230                 235                 240 


Glu Lys Ile Val 
                


<210>  33
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced 
       with the H57 light chain

<400>  33

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Phe 
    50                  55                  60                  


Ala Tyr Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  34
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor with the CD8  Ig domain replaced with the 
       H57 light chain, where the light chain comprises an F32A mutation

<400>  34

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Ala 
    50                  55                  60                  


Ala Tyr Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  35
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced 
       with the H57 light chain, where the light chain comprises an L28A
       mutation

<400>  35

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Ala Pro Lys Asn Phe 
    50                  55                  60                  


Ala Tyr Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  36
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor with the CD8  Ig domain replaced with the 
       H57 light chain, where the light chain comprises a Y34A mutation

<400>  36

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Phe 
    50                  55                  60                  


Ala Ala Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  37
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor SCoR with the CD8  Ig domain replaced with 
       the H57 heavy chain, where the heavy chain comprises a W33A 
       mutation

<400>  37

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Phe 
    50                  55                  60                  


Ala Tyr Ala Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  38
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced 
       with the H57 light chain where the light chain comprises a F32V 
       mutation

<400>  38

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Val 
    50                  55                  60                  


Ala Tyr Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  39
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced 
       with the H57 light chain, where the light chain comprises a F32L 
       mutation

<400>  39

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly 
        35                  40                  45              


Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Leu 
    50                  55                  60                  


Ala Tyr Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile 
65                  70                  75                  80  


Tyr Met Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                85                  90                  95      


Ser Thr Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro 
            100                 105                 110         


Glu Asp Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn 
        115                 120                 125             


Asp Leu Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gly Asp 
    130                 135                 140                 


Val Leu Pro Thr Thr Ala Pro Thr Lys Lys Thr Thr Leu Lys Met Lys 
145                 150                 155                 160 


Lys Lys Lys Gln Cys Pro Phe Pro His Pro Glu Thr Gln Lys Gly Leu 
                165                 170                 175     


Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu Val Val Cys Ile Leu Leu 
            180                 185                 190         


Leu Leu Ala Phe Leu Gly Val Ala Val Tyr Phe Tyr Cys Val Arg Arg 
        195                 200                 205             


Arg Ala Arg Ile His Phe Met Lys Gln Phe His Lys 
    210                 215                 220 


<210>  40
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Recptor (SCoR) with the CD8beta Ig domain replaced 
       with the 2C11 heavy chain

<400>  40

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            20                  25                  30          


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu 
65                  70                  75                  80  


Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp 
                85                  90                  95      


Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu 
            100                 105                 110         


Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr 
        115                 120                 125             


Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Met Val Thr Val Ser Ser Gly Asp Val Leu Pro Thr Thr Ala Pro Thr 
145                 150                 155                 160 


Lys Lys Thr Thr Leu Lys Met Lys Lys Lys Lys Gln Cys Pro Phe Pro 
                165                 170                 175     


His Pro Glu Thr Gln Lys Gly Leu Thr Cys Ser Leu Thr Thr Leu Ser 
            180                 185                 190         


Leu Leu Val Val Cys Ile Leu Leu Leu Leu Ala Phe Leu Gly Val Ala 
        195                 200                 205             


Val Tyr Phe Tyr Cys Val Arg Arg Arg Ala Arg Ile His Phe Met Lys 
    210                 215                 220                 


Gln Phe His Lys 
225             


<210>  41
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  urrogate Co-Receptor (SCoR) with the CD8alpha Ig domain replaced 
       with the 2C11 light chain

<400>  41

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Thr Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Thr Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg 
    130                 135                 140                 


Thr Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro 
145                 150                 155                 160 


Glu Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe 
                165                 170                 175     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala 
            180                 185                 190         


Pro Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg 
        195                 200                 205             


Lys Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys 
    210                 215                 220                 


Pro Arg Pro Ser Glu Lys Ile Val 
225                 230         


<210>  42
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surrogate Co-Receptor (SCoR) with the CD8  Ig domain replaced 
       with the 2C11 light chain with W135A mutation

<400>  42

Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu 
        35                  40                  45              


Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Phe Asp Ala Asp Lys Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Asp Val Leu Pro Thr Thr Ala Pro Thr 
        115                 120                 125             


Lys Lys Thr Thr Leu Lys Met Lys Lys Lys Lys Gln Cys Pro Phe Pro 
    130                 135                 140                 


His Pro Glu Thr Gln Lys Gly Leu Thr Cys Ser Leu Thr Thr Leu Ser 
145                 150                 155                 160 


Leu Leu Val Val Cys Ile Leu Leu Leu Leu Ala Phe Leu Gly Val Ala 
                165                 170                 175     


Val Tyr Phe Tyr Cys Val Arg Arg Arg Ala Arg Ile His Phe Met Lys 
            180                 185                 190         


Gln Phe His Lys 
        195     


<210>  43
<211>  457
<212>  PRT
<213>  Mus musculus

<400>  43

Met Cys Arg Ala Ile Ser Leu Arg Arg Leu Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Leu Ser Gln Leu Leu Ala Val Thr Gln Gly Lys Thr Leu Val Leu Gly 
            20                  25                  30          


Lys Glu Gly Glu Ser Ala Glu Leu Pro Cys Glu Ser Ser Gln Lys Lys 
        35                  40                  45              


Ile Thr Val Phe Thr Trp Lys Phe Ser Asp Gln Arg Lys Ile Leu Gly 
    50                  55                  60                  


Gln His Gly Lys Gly Val Leu Ile Arg Gly Gly Ser Pro Ser Gln Phe 
65                  70                  75                  80  


Asp Arg Phe Asp Ser Lys Lys Gly Ala Trp Glu Lys Gly Ser Phe Pro 
                85                  90                  95      


Leu Ile Ile Asn Lys Leu Lys Met Glu Asp Ser Gln Thr Tyr Ile Cys 
            100                 105                 110         


Glu Leu Glu Asn Arg Lys Glu Glu Val Glu Leu Trp Val Phe Lys Val 
        115                 120                 125             


Thr Phe Ser Pro Gly Thr Ser Leu Leu Gln Gly Gln Ser Leu Thr Leu 
    130                 135                 140                 


Thr Leu Asp Ser Asn Ser Lys Val Ser Asn Pro Leu Thr Glu Cys Lys 
145                 150                 155                 160 


His Lys Lys Gly Lys Val Val Ser Gly Ser Lys Val Leu Ser Met Ser 
                165                 170                 175     


Asn Leu Arg Val Gln Asp Ser Asp Phe Trp Asn Cys Thr Val Thr Leu 
            180                 185                 190         


Asp Gln Lys Lys Asn Trp Phe Gly Met Thr Leu Ser Val Leu Gly Phe 
        195                 200                 205             


Gln Ser Thr Ala Ile Thr Ala Tyr Lys Ser Glu Gly Glu Ser Ala Glu 
    210                 215                 220                 


Phe Ser Phe Pro Leu Asn Phe Ala Glu Glu Asn Gly Trp Gly Glu Leu 
225                 230                 235                 240 


Met Trp Lys Ala Glu Lys Asp Ser Phe Phe Gln Pro Trp Ile Ser Phe 
                245                 250                 255     


Ser Ile Lys Asn Lys Glu Val Ser Val Gln Lys Ser Thr Lys Asp Leu 
            260                 265                 270         


Lys Leu Gln Leu Lys Glu Thr Leu Pro Leu Thr Leu Lys Ile Pro Gln 
        275                 280                 285             


Val Ser Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr Leu Thr Leu Asp 
    290                 295                 300                 


Lys Gly Thr Leu His Gln Glu Val Asn Leu Val Val Met Lys Val Ala 
305                 310                 315                 320 


Gln Leu Asn Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Met Arg Leu Thr Leu Lys Gln Glu Asn Gln Glu Ala Arg Val Ser 
            340                 345                 350         


Glu Glu Gln Lys Val Val Gln Val Val Ala Pro Glu Thr Gly Leu Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Glu Gly Asp Lys Val Lys Met Asp Ser Arg Ile 
    370                 375                 380                 


Gln Val Leu Ser Arg Gly Val Asn Gln Thr Val Phe Leu Ala Cys Val 
385                 390                 395                 400 


Leu Gly Gly Ser Phe Gly Phe Leu Gly Phe Leu Gly Leu Cys Ile Leu 
                405                 410                 415     


Cys Cys Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser 
            420                 425                 430         


Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
        435                 440                 445             


Arg Met Gln Lys Ser His Asn Leu Ile 
    450                 455         


<210>  44
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  44

Met Gly Cys Val Cys Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser 
            20                  25                  30          


Lys Ile Ser Leu Pro Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Asp Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Lys Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Pro Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Asn Val Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Gln Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr His Leu Met Met Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Asp Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  45
<211>  30
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  CD4 clasp cysteine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  CD4 clasp cysteine

<400>  45

Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser Gln Ile 
1               5                   10                  15      


Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
            20                  25                  30  


<210>  46
<211>  66
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lck clasp cysteines

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Lck clasp cysteines

<400>  46

Met Gly Cys Val Cys Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser 
            20                  25                  30          


Lys Ile Ser Leu Pro Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val 
65      


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Lck (CD4JM Link)

<400>  47

Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser Gln Ile 
1               5                   10                  15      


Lys Arg Leu Leu Ser Glu Lys Lys Thr Gly Thr Ser His Tyr 
            20                  25                  30  


<210>  48
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Lck (Lck linkage)


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  CD4 originating sequence

<220>
<221>  MISC_FEATURE
<222>  (3)..(6)
<223>  Linakge sequence

<220>
<221>  MISC_FEATURE
<222>  (7)..(34)
<223>  Lck originating sequence

<220>
<221>  MISC_FEATURE
<222>  (7)..(30)
<223>  Lck originating sequence

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Lck clasp cysteines

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Lck clasp cysteines

<400>  48

Val Arg Ala Ala Ala Ser Gly Cys Val Cys Ser Ser Asn Pro Glu Asp 
1               5                   10                  15      


Asp Trp Met Glu Asn Ile Asp Val Cys Glu Asn Cys His Tyr 
            20                  25                  30  


<210>  49
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Lck (Lck SH3 linkage)


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  CD4 originating sequence

<220>
<221>  MISC_FEATURE
<222>  (3)..(6)
<223>  Linkage sequence

<220>
<221>  MISC_FEATURE
<222>  (7)..(34)
<223>  Lck originating sequence

<400>  49

Val Arg Ala Ala Ala Ser Asp Asn Leu Val Ile Ala Leu His Ser Tyr 
1               5                   10                  15      


Glu Pro Ser His Asp Gly Asp Leu Gly Phe Glu Lys Gly Glu Gln Leu 
            20                  25                  30          


Arg Ile 
        


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4-Lck (Lck Spe linkage)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  CD4 originating sequence

<220>
<221>  MISC_FEATURE
<222>  (26)..(28)
<223>  Linkage sequence

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  Lck originating sequence

<400>  50

Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser Gln Ile 
1               5                   10                  15      


Lys Arg Leu Leu Ser Glu Lys Lys Thr Gly Thr Ser His Tyr 
            20                  25                  30  


