
                                SEQUENCE LISTING

<110> Goncalves, Marcus
      Cantley, Lewis C.
      Yun, Jihye
      Cornell University
      Baylor College of Medicine

<120> Anti-Fructose Therapy for Colorectal and
  Small Intestine Cancers
  

<130> 1676.145WO1

<140> PCT/US2020/024012   
<141> 2020-03-20  

<150> US 62/821,546       
<151> 2019-03-21  

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val
 1               5                  10                  15
Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr
            20                  25                  30
Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln
        35                  40                  45
Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp
    50                  55                  60
Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe
65                  70                  75                  80
Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe
                85                  90                  95
Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro
            100                 105                 110
Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile
        115                 120                 125
Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn
    130                 135                 140
Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly
145                 150                 155                 160
Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val
                165                 170                 175
Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Trp
            180                 185                 190
Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala Ala Leu Gln Leu Leu
        195                 200                 205
Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr Leu Leu Ile Gln Lys
    210                 215                 220
Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln Thr Leu Arg Gly Trp
225                 230                 235                 240
Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg Gln Glu Asp Glu Ala
                245                 250                 255
Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys Leu Phe Arg Met Arg
            260                 265                 270
Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val Leu Met Gly Gly Gln
        275                 280                 285
Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr Ala Asp Gln Ile Tyr
    290                 295                 300
Leu Ser Ala Gly Val Pro Glu Glu His Val Gln Tyr Val Thr Ala Gly
305                 310                 315                 320
Thr Gly Ala Val Asn Val Val Met Thr Phe Cys Ala Val Phe Val Val
                325                 330                 335
Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu Gly Phe Ser Ile Cys
            340                 345                 350
Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu Ala Leu Gln Asp Thr
        355                 360                 365
Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys Val Ile Ser Tyr Val
    370                 375                 380
Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro Ala Leu Leu Ile Thr
385                 390                 395                 400
Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala Phe Met Val Gly Gly
                405                 410                 415
Ser Val His Trp Leu Ser Asn Phe Thr Val Gly Leu Ile Phe Pro Phe
            420                 425                 430
Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile Val Phe Ala Val Ile
        435                 440                 445
Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile Val Pro Glu Thr Lys
    450                 455                 460
Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe Thr Lys Met Asn Lys
465                 470                 475                 480
Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu Lys Glu Leu Pro Pro
                485                 490                 495
Val Thr Ser Glu Gln
            500

<210> 2
<211> 2383
<212> DNA
<213> Homo sapiens

<400> 2
gcttctcaca gtctcccacc ccgccctgct cgcggagcct gcaggcctcg gcctcatggc      60
ggcctgaggc aggggcctgg aggctggtcc gcccgccacg aaggttgggg ggtccctggc     120
cagaagcagg acccgggcga ggctgagggg gactctggca gaagctgaag gggacccggt     180
gcacgcgtta ctttggctaa aaggaggtga gcggcactct gcccttccag agcaagcatg     240
gagcaacagg atcagagcat gaaggaaggg aggctgacgc ttgtgcttgc cctggcaacc     300
ctgatagctg cctttgggtc atccttccag tatgggtaca acgtggctgc tgtcaactcc     360
ccagcactgc tcatgcaaca attttacaat gagacttact atggtaggac cggtgaattc     420
atggaagact tccccttgac gttgctgtgg tctgtaaccg tgtccatgtt tccatttgga     480
gggtttatcg gatccctcct ggtcggcccc ttggtgaata aatttggcag aaaaggggcc     540
ttgctgttca acaacatatt ttctatcgtg cctgcgatct taatgggatg cagcagagtc     600
gccacatcat ttgagcttat cattatttcc agacttttgg tgggaatatg tgcaggtgta     660
tcttccaacg tggtccccat gtacttaggg gagctggccc ctaaaaacct gcggggggct     720
ctcggggtgg tgccccagct cttcatcact gttggcatcc ttgtggccca gatctttggt     780
cttcggaatc tccttgcaaa cgtagatggc tggccgatcc tgctggggct gaccggggtc     840
cccgcggcgc tgcagctcct tctgctgccc ttcttccccg agagccccag gtacctgctg     900
attcagaaga aagacgaagc ggccgccaag aaagccctac agacgctgcg cggctgggac     960
tctgtggaca gggaggtggc cgagatccgg caggaggatg aggcagagaa ggccgcgggc    1020
ttcatctccg tgctgaagct gttccggatg cgctcgctgc gctggcagct gctgtccatc    1080
atcgtcctca tgggcggcca gcagctgtcg ggcgtcaacg ctatctacta ctacgcggac    1140
cagatctacc tgagcgccgg cgtgccggag gagcacgtgc agtacgtgac ggccggcacc    1200
ggggccgtga acgtggtcat gaccttctgc gccgtgttcg tggtggagct cctgggtcgg    1260
aggctgctgc tgctgctggg cttctccatc tgcctcatag cctgctgcgt gctcactgca    1320
gctctggcac tgcaggacac agtgtcctgg atgccataca tcagcatcgt ctgtgtcatc    1380
tcctacgtca taggacatgc cctcgggccc agtcccatac ccgcgctgct catcactgag    1440
atcttcctgc agtcctctcg gccatctgcc ttcatggtgg ggggcagtgt gcactggctc    1500
tccaacttca ccgtgggctt gatcttcccg ttcatccagg agggcctcgg cccgtacagc    1560
ttcattgtct tcgccgtgat ctgcctcctc accaccatct acatcttctt gattgtcccg    1620
gagaccaagg ccaagacgtt catagagatc aaccagattt tcaccaagat gaataaggtg    1680
tctgaagtgt acccggaaaa ggaggaactg aaagagcttc cacctgtcac ttcggaacag    1740
tgactctgga gaggaagcca gtggagctgg tctgccaggg gcttcccact ttggcttatt    1800
tttctgactt ctagctgtct gtgaatatcc agaaataaaa caactctgat gtggaatgca    1860
gtcctcatct ccagcctccc caccccagtg ggaactgtgc aaagggctgc cttgctgttc    1920
ttgaagctgg gctgtctctc tccatgttgg cctgtcacca gacccgagtc aattaaacag    1980
ctggtcctcc actttgctgg ttcagccttc gtgtggctcc tggtaacgtg gctccacctt    2040
gatgggtcaa cctttgtgtg gctcctggta acataacaac aacagttact atagtggtga    2100
gatggaagga atcaaatttt gccagagaaa ctaacttggt ggccccgaca ggtcttccgg    2160
ggccatgggc atttgtttag agccaaattc atcctcttac cagatccttt tccagaaata    2220
cctgtctagg aaggtgtgat gtcagaaaca atgacatcca gaaagctgag gaacaggttc    2280
ctgtggagac actgagtcag aattcttcat cctaaattat tttgttagtg gaaaatggaa    2340
ttgcttctgt gtagtcaata aaatgaacct gatcactttt caa                      2383

<210> 3
<211> 501
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val
 1               5                  10                  15
Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr
            20                  25                  30
Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln
        35                  40                  45
Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp
    50                  55                  60
Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe
65                  70                  75                  80
Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe
                85                  90                  95
Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro
            100                 105                 110
Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile
        115                 120                 125
Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn
    130                 135                 140
Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly
145                 150                 155                 160
Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val
                165                 170                 175
Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Trp
            180                 185                 190
Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala Ala Leu Gln Leu Leu
        195                 200                 205
Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr Leu Leu Ile Gln Lys
    210                 215                 220
Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln Thr Leu Arg Gly Trp
225                 230                 235                 240
Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg Gln Glu Asp Glu Ala
                245                 250                 255
Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys Leu Phe Arg Met Arg
            260                 265                 270
Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val Leu Met Gly Gly Gln
        275                 280                 285
Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr Ala Asp Gln Ile Tyr
    290                 295                 300
Leu Ser Ala Gly Val Pro Glu Glu His Val Gln Tyr Val Thr Ala Gly
305                 310                 315                 320
Thr Gly Ala Val Asn Val Val Met Thr Phe Cys Ala Val Phe Val Val
                325                 330                 335
Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu Gly Phe Ser Ile Cys
            340                 345                 350
Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu Ala Leu Gln Asp Thr
        355                 360                 365
Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys Val Ile Ser Tyr Val
    370                 375                 380
Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro Ala Leu Leu Ile Thr
385                 390                 395                 400
Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala Phe Met Val Gly Gly
                405                 410                 415
Ser Val His Trp Leu Ser Asn Phe Thr Val Gly Leu Ile Phe Pro Phe
            420                 425                 430
Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile Val Phe Ala Val Ile
        435                 440                 445
Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile Val Pro Glu Thr Lys
    450                 455                 460
Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe Thr Lys Met Asn Lys
465                 470                 475                 480
Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu Lys Glu Leu Pro Pro
                485                 490                 495
Val Thr Ser Glu Gln
            500

<210> 4
<211> 2218
<212> DNA
<213> Homo sapiens

<400> 4
cttctctctc cattcagtgc acgcgttact ttggctaaaa ggaggtgagc ggcactctgc      60
ccttccagag caagcatgga gcaacaggat cagagcatga aggaagggag gctgacgctt     120
gtgcttgccc tggcaaccct gatagctgcc tttgggtcat ccttccagta tgggtacaac     180
gtggctgctg tcaactcccc agcactgctc atgcaacaat tttacaatga gacttactat     240
ggtaggaccg gtgaattcat ggaagacttc cccttgacgt tgctgtggtc tgtaaccgtg     300
tccatgtttc catttggagg gtttatcgga tccctcctgg tcggcccctt ggtgaataaa     360
tttggcagaa aaggggcctt gctgttcaac aacatatttt ctatcgtgcc tgcgatctta     420
atgggatgca gcagagtcgc cacatcattt gagcttatca ttatttccag acttttggtg     480
ggaatatgtg caggtgtatc ttccaacgtg gtccccatgt acttagggga gctggcccct     540
aaaaacctgc ggggggctct cggggtggtg ccccagctct tcatcactgt tggcatcctt     600
gtggcccaga tctttggtct tcggaatctc cttgcaaacg tagatggctg gccgatcctg     660
ctggggctga ccggggtccc cgcggcgctg cagctccttc tgctgccctt cttccccgag     720
agccccaggt acctgctgat tcagaagaaa gacgaagcgg ccgccaagaa agccctacag     780
acgctgcgcg gctgggactc tgtggacagg gaggtggccg agatccggca ggaggatgag     840
gcagagaagg ccgcgggctt catctccgtg ctgaagctgt tccggatgcg ctcgctgcgc     900
tggcagctgc tgtccatcat cgtcctcatg ggcggccagc agctgtcggg cgtcaacgct     960
atctactact acgcggacca gatctacctg agcgccggcg tgccggagga gcacgtgcag    1020
tacgtgacgg ccggcaccgg ggccgtgaac gtggtcatga ccttctgcgc cgtgttcgtg    1080
gtggagctcc tgggtcggag gctgctgctg ctgctgggct tctccatctg cctcatagcc    1140
tgctgcgtgc tcactgcagc tctggcactg caggacacag tgtcctggat gccatacatc    1200
agcatcgtct gtgtcatctc ctacgtcata ggacatgccc tcgggcccag tcccataccc    1260
gcgctgctca tcactgagat cttcctgcag tcctctcggc catctgcctt catggtgggg    1320
ggcagtgtgc actggctctc caacttcacc gtgggcttga tcttcccgtt catccaggag    1380
ggcctcggcc cgtacagctt cattgtcttc gccgtgatct gcctcctcac caccatctac    1440
atcttcttga ttgtcccgga gaccaaggcc aagacgttca tagagatcaa ccagattttc    1500
accaagatga ataaggtgtc tgaagtgtac ccggaaaagg aggaactgaa agagcttcca    1560
cctgtcactt cggaacagtg actctggaga ggaagccagt ggagctggtc tgccaggggc    1620
ttcccacttt ggcttatttt tctgacttct agctgtctgt gaatatccag aaataaaaca    1680
actctgatgt ggaatgcagt cctcatctcc agcctcccca ccccagtggg aactgtgcaa    1740
agggctgcct tgctgttctt gaagctgggc tgtctctctc catgttggcc tgtcaccaga    1800
cccgagtcaa ttaaacagct ggtcctccac tttgctggtt cagccttcgt gtggctcctg    1860
gtaacgtggc tccaccttga tgggtcaacc tttgtgtggc tcctggtaac ataacaacaa    1920
cagttactat agtggtgaga tggaaggaat caaattttgc cagagaaact aactcggtgg    1980
ccccaacagg tcttccgggg ccatgggcat ttgtttagag ccaaattcat cctcttacca    2040
gatccttttc cagaaatacc tgtctaggaa ggtgtgatgt cagaaacaat gacatccaga    2100
aagctgagga acaggttcct gtggagacac tgagtcagaa ttcttcatcc aaattatttt    2160
gttagtggaa aatggaattg cttctgtgta gtcaataaaa tgaacctgat cacttttc      2218

<210> 5
<211> 298
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val
 1               5                  10                  15
Ile Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys
            20                  25                  30
Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr
        35                  40                  45
Val Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala
    50                  55                  60
Pro Gly His Val Ala Asp Phe Leu Val Ala Asp Phe Arg Arg Arg Gly
65                  70                  75                  80
Val Asp Val Ser Gln Val Ala Trp Gln Ser Lys Gly Asp Thr Pro Ser
                85                  90                  95
Ser Cys Cys Ile Ile Asn Asn Ser Asn Gly Asn Arg Thr Ile Val Leu
            100                 105                 110
His Asp Thr Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val
        115                 120                 125
Asp Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser
    130                 135                 140
Glu Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln
145                 150                 155                 160
Pro Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg
                165                 170                 175
Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser
            180                 185                 190
Lys Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu
        195                 200                 205
Arg Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala
    210                 215                 220
Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu
225                 230                 235                 240
His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala
                245                 250                 255
Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg
            260                 265                 270
Ser Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys
        275                 280                 285
Cys Gly Leu Gln Gly Phe Asp Gly Ile Val
    290                 295

<210> 6
<211> 2397
<212> DNA
<213> Homo sapiens

<400> 6
aggcagggct gcagatgcga ggcccagctg tacctcgcgt gtcccgggtc gggagtcgga      60
gacgcaggtg caggagagtg cggggcaagt agcgcatttt ctctttgcat tctcgagatc     120
gcttagccgc gctttaaaaa ggtttgcatc agctgtgagt ccatctgaca agcgaggaaa     180
ctaaggctga gaagtgggag gcgttgccat ctgcaggccc aggcaacctg ctacgggaag     240
accggggacc aagacctctg ggttggcttt cctagacccg ctcgggtctt cgggtgtcgc     300
gaggaagggc cctgctcctt tcgttccctg cacccctggc cgctgcaggt ggctccctgg     360
aggaggagct cccacgcgga ggaggagcca gggcagctgg gagcggggac accatcctcc     420
tggataagag gcagaggccg ggaggaaccc cgtcagccgg gcgggcagga agctctggga     480
gtagcctcat ggaagagaag cagatcctgt gcgtggggct agtggtgctg gacgtcatca     540
gcctggtgga caagtaccct aaggaggact cggagataag gtgtttgtcc cagagatggc     600
agcgcggagg caacgcgtcc aactcctgca ccgttctctc cctgctcgga gccccctgtg     660
ccttcatggg ctcaatggct cctggccatg ttgctgactt cctggtggcc gacttcaggc     720
ggcggggcgt ggacgtgtct caggtggcct ggcagagcaa gggggacacc cccagctcct     780
gctgcatcat caacaactcc aatggcaacc gtaccattgt gctccatgac acgagcctgc     840
cagatgtgtc tgctacagac tttgagaagg ttgatctgac ccagttcaag tggatccaca     900
ttgagggccg gaacgcatcg gagcaggtga agatgctgca gcggatagac gcacacaaca     960
ccaggcagcc tccagagcag aagatccggg tgtccgtgga ggtggagaag ccacgagagg    1020
agctcttcca gctgtttggc tacggagacg tggtgtttgt cagcaaagat gtggccaagc    1080
acttggggtt ccagtcagca gaggaagcct tgaggggctt gtatggtcgt gtgaggaaag    1140
gggctgtgct tgtctgtgcc tgggctgagg agggcgccga cgccctgggc cctgatggca    1200
aattgctcca ctcggatgct ttcccgccac cccgcgtggt ggatacactg ggagctggag    1260
acaccttcaa tgcctccgtc atcttcagcc tctcccaggg gaggagcgtg caggaagcac    1320
tgagattcgg gtgccaggtg gccggcaaga agtgtggcct gcagggcttt gatggcatcg    1380
tgtgagagca ggtgccggct cctcacacac catggagact accattgcgg ctgcatcgcc    1440
ttctcccctc catccagcct ggcgtccagg ttgccctgtt caggggacag atgcaagctg    1500
tggggaggac tctgcctgtg tcctgtgttc cccacaggga gaggctctgg ggggatggct    1560
gggggatgca gagcctcaga gcaaataaat cttcctcaga gccagcttct cctctcaatg    1620
tctgaactgc tctggctggg cattcctgag gctctgactc ttcgatcctc cctctttgtg    1680
tccattcccc aaattaacct ctccgcccag gcccagagga ggggctgcct gggctagagc    1740
agcgagaagt gccctgggct tgccaccagc tctgccctgg ctggggagga cactcggtgc    1800
cccacaccca gtgaacctgc caaagaaacc gtgagagctc ttcggggccc tgcgttgtgc    1860
agactctatt cccacagctc agaagctggg agtccacacc gctgagctga actgacaggc    1920
cagtgggggg caggggtgcg cctcctctgc cctgcccacc agcctgtgat ttgatggggt    1980
cttcattgtc cagaaatacc tcctcccgct gactgcccca gagcctgaaa gtctcaccct    2040
tggagcccac cttggaatta agggcgtgcc tcagccacaa atgtgaccca ggatacagag    2100
tgttgctgtc ctcagggagg tccgatctgg aacacatatt ggaattgggg ccaactccaa    2160
tatagggtgg gtaaggcctt ataatgtaaa gagcatataa tgtaaagggc tttagagtga    2220
gacagacctg gattaaaatc tgccatttaa ttagctgcat atcaccttag ggtacagcac    2280
ttaacgcaat ctgcctcaat ttcttcatct gtcaaatgga accaattctg cttggctaca    2340
gaattattgt gaggataaaa tcatatataa aatgcccagc atgatgcctg atgtgta       2397

<210> 7
<211> 313
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
 1               5                  10                  15
Arg Gly Ser Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val Ile
            20                  25                  30
Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys Leu
        35                  40                  45
Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr Val
    50                  55                  60
Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala Pro
65                  70                  75                  80
Gly His Val Ala Asp Phe Leu Val Ala Asp Phe Arg Arg Arg Gly Val
                85                  90                  95
Asp Val Ser Gln Val Ala Trp Gln Ser Lys Gly Asp Thr Pro Ser Ser
            100                 105                 110
Cys Cys Ile Ile Asn Asn Ser Asn Gly Asn Arg Thr Ile Val Leu His
        115                 120                 125
Asp Thr Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val Asp
    130                 135                 140
Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser Glu
145                 150                 155                 160
Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln Pro
                165                 170                 175
Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg Glu
            180                 185                 190
Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser Lys
        195                 200                 205
Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu Arg
    210                 215                 220
Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala Trp
225                 230                 235                 240
Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu His
                245                 250                 255
Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala Gly
            260                 265                 270
Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg Ser
        275                 280                 285
Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys Cys
    290                 295                 300
Gly Leu Gln Gly Phe Asp Gly Ile Val
305                 310

<210> 8
<211> 298
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val
 1               5                  10                  15
Ile Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys
            20                  25                  30
Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr
        35                  40                  45
Val Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala
    50                  55                  60
Pro Gly His Val Ala Asp Phe Leu Val Ala Asp Phe Arg Arg Arg Gly
65                  70                  75                  80
Val Asp Val Ser Gln Val Ala Trp Gln Ser Lys Gly Asp Thr Pro Ser
                85                  90                  95
Ser Cys Cys Ile Ile Asn Asn Ser Asn Gly Asn Arg Thr Ile Val Leu
            100                 105                 110
His Asp Thr Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val
        115                 120                 125
Asp Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser
    130                 135                 140
Glu Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln
145                 150                 155                 160
Pro Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg
                165                 170                 175
Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser
            180                 185                 190
Lys Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu
        195                 200                 205
Arg Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala
    210                 215                 220
Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu
225                 230                 235                 240
His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala
                245                 250                 255
Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg
            260                 265                 270
Ser Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys
        275                 280                 285
Cys Gly Leu Gln Gly Phe Asp Gly Ile Val
    290                 295

<210> 9
<211> 1000
<212> DNA
<213> Homo sapiens

<400> 9
gtagcctcat ggaagagaag cagatcctgt gcgtggggct agtggtgctg gacgtcatca      60
gcctggtgga caagtaccct aaggaggact cggagataag gtgtttgtcc cagagatggc     120
agcgcggagg caacgcgtcc aactcctgca ccgttctctc cctgctcgga gccccctgtg     180
ccttcatggg ctcaatggct cctggccatg ttgctgattt tgtcctggat gacctccgcc     240
gctattctgt ggacctacgc tacacagtct ttcagaccac aggctccgtc cccatcgcca     300
cggtcatcat caacgaggcc agtggtagcc gcaccatcct atactatgac aggagcctgc     360
cagatgtgtc tgctacagac tttgagaagg ttgatctgac ccagttcaag tggatccaca     420
ttgagggccg gaacgcatcg gagcaggtga agatgctgca gcggatagac gcacacaaca     480
ccaggcagcc tccagagcag aagatccggg tgtccgtgga ggtggagaag ccacgagagg     540
agctcttcca gctgtttggc tacggagacg tggtgtttgt cagcaaagat gtggccaagc     600
acttggggtt ccagtcagca gaggaagcct tgaggggctt gtatggtcgt gtgaggaaag     660
gggctgtgct tgtctgtgcc tgggctgagg agggcgccga cgccctgggc cctgatggca     720
aattgctcca ctcggatgct ttcccgccac cccgcgtggt ggatacactg ggagctggag     780
acaccttcaa tgcctccgtc atcttcagcc tctcccaggg gaggagcgtg caggaagcac     840
tgagattcgg gtgccaggtg gccggcaaga agtgtggcct gcagggcttt gatggcatcg     900
tgtgagagca ggtgccggct cctcacacac catggagact accattgcgg ctgcatcgcc     960
ttctcccctc catccagcct ggcgtccagg ttgccctgtt                          1000

<210> 10
<211> 298
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val
 1               5                  10                  15
Ile Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys
            20                  25                  30
Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr
        35                  40                  45
Val Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala
    50                  55                  60
Pro Gly His Val Ala Asp Phe Val Leu Asp Asp Leu Arg Arg Tyr Ser
65                  70                  75                  80
Val Asp Leu Arg Tyr Thr Val Phe Gln Thr Thr Gly Ser Val Pro Ile
                85                  90                  95
Ala Thr Val Ile Ile Asn Glu Ala Ser Gly Ser Arg Thr Ile Leu Tyr
            100                 105                 110
Tyr Asp Arg Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val
        115                 120                 125
Asp Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser
    130                 135                 140
Glu Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln
145                 150                 155                 160
Pro Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg
                165                 170                 175
Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser
            180                 185                 190
Lys Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu
        195                 200                 205
Arg Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala
    210                 215                 220
Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu
225                 230                 235                 240
His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala
                245                 250                 255
Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg
            260                 265                 270
Ser Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys
        275                 280                 285
Cys Gly Leu Gln Gly Phe Asp Gly Ile Val
    290                 295

<210> 11
<211> 2397
<212> DNA
<213> Homo sapiens

<400> 11
aggcagggct gcagatgcga ggcccagctg tacctcgcgt gtcccgggtc gggagtcgga      60
gacgcaggtg caggagagtg cggggcaagt agcgcatttt ctctttgcat tctcgagatc     120
gcttagccgc gctttaaaaa ggtttgcatc agctgtgagt ccatctgaca agcgaggaaa     180
ctaaggctga gaagtgggag gcgttgccat ctgcaggccc aggcaacctg ctacgggaag     240
accggggacc aagacctctg ggttggcttt cctagacccg ctcgggtctt cgggtgtcgc     300
gaggaagggc cctgctcctt tcgttccctg cacccctggc cgctgcaggt ggctccctgg     360
aggaggagct cccacgcgga ggaggagcca gggcagctgg gagcggggac accatcctcc     420
tggataagag gcagaggccg ggaggaaccc cgtcagccgg gcgggcagga agctctggga     480
gtagcctcat ggaagagaag cagatcctgt gcgtggggct agtggtgctg gacgtcatca     540
gcctggtgga caagtaccct aaggaggact cggagataag gtgtttgtcc cagagatggc     600
agcgcggagg caacgcgtcc aactcctgca ccgttctctc cctgctcgga gccccctgtg     660
ccttcatggg ctcaatggct cctggccatg ttgctgattt tgtcctggat gacctccgcc     720
gctattctgt ggacctacgc tacacagtct ttcagaccac aggctccgtc cccatcgcca     780
cggtcatcat caacgaggcc agtggtagcc gcaccatcct atactatgac aggagcctgc     840
cagatgtgtc tgctacagac tttgagaagg ttgatctgac ccagttcaag tggatccaca     900
ttgagggccg gaacgcatcg gagcaggtga agatgctgca gcggatagac gcacacaaca     960
ccaggcagcc tccagagcag aagatccggg tgtccgtgga ggtggagaag ccacgagagg    1020
agctcttcca gctgtttggc tacggagacg tggtgtttgt cagcaaagat gtggccaagc    1080
acttggggtt ccagtcagca gaggaagcct tgaggggctt gtatggtcgt gtgaggaaag    1140
gggctgtgct tgtctgtgcc tgggctgagg agggcgccga cgccctgggc cctgatggca    1200
aattgctcca ctcggatgct ttcccgccac cccgcgtggt ggatacactg ggagctggag    1260
acaccttcaa tgcctccgtc atcttcagcc tctcccaggg gaggagcgtg caggaagcac    1320
tgagattcgg gtgccaggtg gccggcaaga agtgtggcct gcagggcttt gatggcatcg    1380
tgtgagagca ggtgccggct cctcacacac catggagact accattgcgg ctgcatcgcc    1440
ttctcccctc catccagcct ggcgtccagg ttgccctgtt caggggacag atgcaagctg    1500
tggggaggac tctgcctgtg tcctgtgttc cccacaggga gaggctctgg ggggatggct    1560
gggggatgca gagcctcaga gcaaataaat cttcctcaga gccagcttct cctctcaatg    1620
tctgaactgc tctggctggg cattcctgag gctctgactc ttcgatcctc cctctttgtg    1680
tccattcccc aaattaacct ctccgcccag gcccagagga ggggctgcct gggctagagc    1740
agcgagaagt gccctgggct tgccaccagc tctgccctgg ctggggagga cactcggtgc    1800
cccacaccca gtgaacctgc caaagaaacc gtgagagctc ttcggggccc tgcgttgtgc    1860
agactctatt cccacagctc agaagctggg agtccacacc gctgagctga actgacaggc    1920
cagtgggggg caggggtgcg cctcctctgc cctgcccacc agcctgtgat ttgatggggt    1980
cttcattgtc cagaaatacc tcctcccgct gactgcccca gagcctgaaa gtctcaccct    2040
tggagcccac cttggaatta agggcgtgcc tcagccacaa atgtgaccca ggatacagag    2100
tgttgctgtc ctcagggagg tccgatctgg aacacatatt ggaattgggg ccaactccaa    2160
tatagggtgg gtaaggcctt ataatgtaaa gagcatataa tgtaaagggc tttagagtga    2220
gacagacctg gattaaaatc tgccatttaa ttagctgcat atcaccttag ggtacagcac    2280
ttaacgcaat ctgcctcaat ttcttcatct gtcaaatgga accaattctg cttggctaca    2340
gaattattgt gaggataaaa tcatatataa aatgcccagc atgatgcctg atgtgta       2397

<210> 12
<211> 1634
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Ser Thr Gln Asp Asn Gly Glu His Trp Lys Ser Leu Glu Ser
 1               5                  10                  15
Val Gly Ile Ser Arg Lys Glu Leu Ala Met Ala Glu Ala Leu Gln Met
            20                  25                  30
Glu Tyr Asp Ala Leu Ser Arg Leu Arg His Asp Lys Glu Glu Asn Arg
        35                  40                  45
Ala Lys Gln Asn Ala Asp Pro Ser Leu Ile Ser Trp Asp Glu Pro Gly
    50                  55                  60
Val Asp Phe Tyr Ser Lys Pro Ala Gly Arg Arg Thr Asp Leu Lys Leu
65                  70                  75                  80
Leu Arg Gly Leu Ser Gly Ser Asp Pro Thr Leu Asn Tyr Asn Ser Leu
                85                  90                  95
Ser Pro Gln Glu Gly Pro Pro Asn His Ser Thr Ser Gln Gly Pro Gln
            100                 105                 110
Pro Gly Ser Asp Pro Trp Pro Lys Gly Ser Leu Ser Gly Asp Tyr Leu
        115                 120                 125
Tyr Ile Phe Asp Gly Ser Asp Gly Gly Val Ser Ser Ser Pro Gly Pro
    130                 135                 140
Gly Asp Ile Glu Gly Ser Cys Lys Lys Leu Ser Pro Pro Pro Leu Pro
145                 150                 155                 160
Pro Arg Ala Ser Ile Trp Asp Thr Pro Pro Leu Pro Pro Arg Lys Gly
                165                 170                 175
Ser Pro Ser Ser Ser Lys Ile Ser Gln Pro Ser Asp Ile Asn Thr Phe
            180                 185                 190
Ser Leu Val Glu Gln Leu Pro Gly Lys Leu Leu Glu His Arg Ile Leu
        195                 200                 205
Glu Glu Glu Glu Val Leu Gly Gly Gly Gly Gln Gly Arg Leu Leu Gly
    210                 215                 220
Ser Val Asp Tyr Asp Gly Ile Asn Asp Ala Ile Thr Arg Leu Asn Leu
225                 230                 235                 240
Lys Ser Thr Tyr Asp Val Glu Met Leu Arg Asp Ala Thr Arg Gly Trp
                245                 250                 255
Lys Glu Gly Arg Gly Pro Leu Asp Phe Ser Lys Asp Thr Ser Gly Lys
            260                 265                 270
Pro Val Ala Arg Ser Lys Thr Met Pro Pro Gln Val Pro Pro Arg Thr
        275                 280                 285
Tyr Ala Ser Arg Tyr Gly Asn Arg Lys Asn Ala Thr Pro Gly Lys Asn
    290                 295                 300
Arg Arg Ile Ser Ala Ala Pro Val Gly Ser Arg Pro His Thr Val Ala
305                 310                 315                 320
Asn Gly His Glu Leu Phe Glu Val Ser Glu Glu Arg Asp Glu Glu Val
                325                 330                 335
Ala Ala Phe Cys His Met Leu Asp Ile Leu Arg Ser Gly Ser Asp Ile
            340                 345                 350
Gln Asp Tyr Phe Leu Thr Gly Tyr Val Trp Ser Ala Val Thr Pro Ser
        355                 360                 365
Pro Glu His Leu Gly Asp Glu Val Asn Leu Lys Val Thr Val Leu Cys
    370                 375                 380
Asp Arg Leu Gln Glu Ala Leu Thr Phe Thr Cys Asn Cys Ser Ser Thr
385                 390                 395                 400
Val Asp Leu Leu Ile Tyr Gln Thr Leu Cys Tyr Thr His Asp Asp Leu
                405                 410                 415
Arg Asn Val Asp Val Gly Asp Phe Val Leu Lys Pro Cys Gly Leu Glu
            420                 425                 430
Glu Phe Leu Gln Asn Lys His Ala Leu Gly Ser His Glu Tyr Ile Gln
        435                 440                 445
Tyr Cys Arg Lys Phe Asp Ile Asp Ile Arg Leu Gln Leu Met Glu Gln
    450                 455                 460
Lys Val Val Arg Ser Asp Leu Ala Arg Thr Val Asn Asp Asp Gln Ser
465                 470                 475                 480
Pro Ser Thr Leu Asn Tyr Leu Val His Leu Gln Glu Arg Pro Val Lys
                485                 490                 495
Gln Thr Ile Ser Arg Gln Ala Leu Ser Leu Leu Phe Asp Thr Tyr His
            500                 505                 510
Asn Glu Val Asp Ala Phe Leu Leu Ala Asp Gly Asp Phe Pro Leu Lys
        515                 520                 525
Ala Asp Arg Val Val Gln Ser Val Lys Ala Ile Cys Asn Ala Leu Ala
    530                 535                 540
Ala Val Glu Thr Pro Glu Ile Thr Ser Ala Leu Asn Gln Leu Pro Pro
545                 550                 555                 560
Cys Pro Ser Arg Met Gln Pro Lys Ile Gln Lys Asp Pro Ser Val Leu
                565                 570                 575
Ala Val Arg Glu Asn Arg Glu Lys Val Val Glu Ala Leu Thr Ala Ala
            580                 585                 590
Ile Leu Asp Leu Val Glu Leu Tyr Cys Asn Thr Phe Asn Ala Asp Phe
        595                 600                 605
Gln Thr Ala Val Pro Gly Ser Arg Lys His Asp Leu Val Gln Glu Ala
    610                 615                 620
Cys His Phe Ala Arg Ser Leu Ala Phe Thr Val Tyr Ala Thr His Arg
625                 630                 635                 640
Ile Pro Ile Ile Trp Ala Thr Ser Tyr Glu Asp Phe Tyr Leu Ser Cys
                645                 650                 655
Ser Leu Ser His Gly Gly Lys Asp Met Cys Ser Pro Leu Gln Thr Arg
            660                 665                 670
Arg Ala His Phe Ser Lys Tyr Leu Phe His Leu Ile Val Trp Asp Gln
        675                 680                 685
Gln Ile Cys Phe Pro Val Gln Val Asn Arg Leu Pro Arg Glu Thr Leu
    690                 695                 700
Leu Cys Ala Thr Leu Tyr Ala Leu Pro Ile Pro Pro Pro Gly Ser Ser
705                 710                 715                 720
Ser Glu Ala Asn Lys Gln Arg Arg Val Pro Glu Ala Leu Gly Trp Val
                725                 730                 735
Thr Thr Pro Leu Phe Asn Phe Arg Gln Val Leu Thr Cys Gly Arg Lys
            740                 745                 750
Leu Leu Gly Leu Trp Pro Ala Thr Gln Glu Asn Pro Ser Ala Arg Trp
        755                 760                 765
Ser Ala Pro Asn Phe His Gln Pro Asp Ser Val Ile Leu Gln Ile Asp
    770                 775                 780
Phe Pro Thr Ser Ala Phe Asp Ile Lys Phe Thr Ser Pro Pro Gly Asp
785                 790                 795                 800
Lys Phe Ser Pro Arg Tyr Glu Phe Gly Ser Leu Arg Glu Glu Asp Gln
                805                 810                 815
Arg Lys Leu Lys Asp Ile Met Gln Lys Glu Ser Leu Tyr Trp Leu Thr
            820                 825                 830
Asp Ala Asp Lys Lys Arg Leu Trp Glu Lys Arg Tyr Tyr Cys His Ser
        835                 840                 845
Glu Val Ser Ser Leu Pro Leu Val Leu Ala Ser Ala Pro Ser Trp Glu
    850                 855                 860
Trp Ala Cys Leu Pro Asp Ile Tyr Val Leu Leu Lys Gln Trp Thr His
865                 870                 875                 880
Met Asn His Gln Asp Ala Leu Gly Leu Leu His Ala Thr Phe Pro Asp
                885                 890                 895
Gln Glu Val Arg Arg Met Ala Val Gln Trp Ile Gly Ser Leu Ser Asp
            900                 905                 910
Ala Glu Leu Leu Asp Tyr Leu Pro Gln Leu Val Gln Ala Leu Lys Tyr
        915                 920                 925
Glu Cys Tyr Leu Asp Ser Pro Leu Val Arg Phe Leu Leu Lys Arg Ala
    930                 935                 940
Val Ser Asp Leu Arg Val Thr His Tyr Phe Phe Trp Leu Leu Lys Asp
945                 950                 955                 960
Gly Leu Lys Asp Ser Gln Phe Ser Ile Arg Tyr Gln Tyr Leu Leu Ala
                965                 970                 975
Ala Leu Leu Cys Cys Cys Gly Lys Gly Leu Arg Glu Glu Phe Asn Arg
            980                 985                 990
Gln Cys Trp Leu Val Asn Ala Leu Ala Lys Leu Ala Gln Gln Val Arg
        995                 1000                1005
Glu Ala Ala Pro Ser Ala Arg Gln Gly Ile Leu Arg Thr Gly Leu Glu
    1010                1015                1020
Glu Val Lys Gln Phe Phe Ala Leu Asn Gly Ser Cys Arg Leu Pro Leu
1025                1030                1035                1040
Ser Pro Ser Leu Leu Val Lys Gly Ile Val Pro Arg Asp Cys Ser Tyr
                1045                1050                1055
Phe Asn Ser Asn Ala Val Pro Leu Lys Leu Ser Phe Gln Asn Val Asp
            1060                1065                1070
Pro Leu Gly Glu Asn Ile Arg Val Ile Phe Lys Cys Gly Asp Asp Leu
        1075                1080                1085
Arg Gln Asp Met Leu Thr Leu Gln Met Ile Arg Ile Met Ser Lys Ile
    1090                1095                1100
Trp Val Gln Glu Gly Leu Asp Met Arg Met Val Ile Phe Arg Cys Phe
1105                1110                1115                1120
Ser Thr Gly Arg Gly Arg Gly Met Val Glu Met Ile Pro Asn Ala Glu
                1125                1130                1135
Thr Leu Arg Lys Ile Gln Val Glu His Gly Val Thr Gly Ser Phe Lys
            1140                1145                1150
Asp Arg Pro Leu Ala Asp Trp Leu Gln Lys His Asn Pro Gly Glu Asp
        1155                1160                1165
Glu Tyr Glu Lys Ala Val Glu Asn Phe Ile Tyr Ser Cys Ala Gly Cys
    1170                1175                1180
Cys Val Ala Thr Tyr Val Leu Gly Ile Cys Asp Arg His Asn Asp Asn
1185                1190                1195                1200
Ile Met Leu Lys Thr Thr Gly His Met Phe His Ile Asp Phe Gly Arg
                1205                1210                1215
Phe Leu Gly His Ala Gln Met Phe Gly Asn Ile Lys Arg Asp Arg Ala
            1220                1225                1230
Pro Phe Val Phe Thr Ser Asp Met Ala Tyr Val Ile Asn Gly Gly Asp
        1235                1240                1245
Lys Pro Ser Ser Arg Phe His Asp Phe Val Asp Leu Cys Cys Gln Ala
    1250                1255                1260
Tyr Asn Leu Ile Arg Lys His Thr His Leu Phe Leu Asn Leu Leu Gly
1265                1270                1275                1280
Leu Met Leu Ser Cys Gly Ile Pro Glu Leu Ser Asp Leu Glu Asp Leu
                1285                1290                1295
Lys Tyr Val Tyr Asp Ala Leu Arg Pro Gln Asp Thr Glu Ala Asn Ala
            1300                1305                1310
Thr Thr Tyr Phe Thr Arg Leu Ile Glu Ser Ser Leu Gly Ser Val Ala
        1315                1320                1325
Thr Lys Leu Asn Phe Phe Ile His Asn Leu Ala Gln Met Lys Phe Thr
    1330                1335                1340
Gly Ser Asp Asp Arg Leu Thr Leu Ser Phe Ala Ser Arg Thr His Thr
1345                1350                1355                1360
Leu Lys Ser Ser Gly Arg Ile Ser Asp Val Phe Leu Cys Arg His Glu
                1365                1370                1375
Lys Ile Phe His Pro Asn Lys Gly Tyr Ile Tyr Val Val Lys Val Met
            1380                1385                1390
Arg Glu Asn Thr His Glu Ala Thr Tyr Ile Gln Arg Thr Phe Glu Glu
        1395                1400                1405
Phe Gln Glu Leu His Asn Lys Leu Arg Leu Leu Phe Pro Ser Ser His
    1410                1415                1420
Leu Pro Ser Phe Pro Ser Arg Phe Val Ile Gly Arg Ser Arg Gly Glu
1425                1430                1435                1440
Ala Val Ala Glu Arg Arg Arg Glu Glu Leu Asn Gly Tyr Ile Trp His
                1445                1450                1455
Leu Ile His Ala Pro Pro Glu Val Ala Glu Cys Asp Leu Val Tyr Thr
            1460                1465                1470
Phe Phe His Pro Leu Pro Arg Asp Glu Lys Ala Met Gly Thr Ser Pro
        1475                1480                1485
Ala Pro Lys Ser Ser Asp Gly Thr Trp Ala Arg Pro Val Gly Lys Val
    1490                1495                1500
Gly Gly Glu Val Lys Leu Ser Ile Ser Tyr Lys Asn Asn Lys Leu Phe
1505                1510                1515                1520
Ile Met Val Met His Ile Arg Gly Leu Gln Leu Leu Gln Asp Gly Asn
                1525                1530                1535
Asp Pro Asp Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Pro Gln Lys
            1540                1545                1550
Thr Thr Lys Arg Lys Thr Lys Val Ala Arg Lys Thr Cys Asn Pro Thr
        1555                1560                1565
Tyr Asn Glu Met Leu Val Tyr Asp Gly Ile Pro Lys Gly Asp Leu Gln
    1570                1575                1580
Gln Arg Glu Leu Gln Leu Ser Val Leu Ser Glu Gln Gly Phe Trp Glu
1585                1590                1595                1600
Asn Val Leu Leu Gly Glu Val Asn Ile Arg Leu Arg Glu Leu Asp Leu
                1605                1610                1615
Ala Gln Glu Lys Thr Gly Trp Phe Ala Leu Gly Ser Arg Ser His Gly
            1620                1625                1630
Thr Leu

<210> 13
<211> 7654
<212> DNA
<213> Homo sapiens

<400> 13
actcactata gggctcgagc ggccgcccgg gcaggtaaga atcagaagac atttgtgctt      60
tggggagcag aggccctcag ggtatagaga aggaagaaga gagaggttca ctgtagtcct     120
gaagcagaaa taagacctgt ggctgaagga agccttagca attcactcct tcctcttcct     180
gagaactctc tgtaggaagt ctcacctagc agaggcttca cagtatttca gagaagccaa     240
agattgtttg cctctttgga aactgttatc cttccatcat gactgtgtca ctcctgccac     300
tgttccacca tagagatggc gtcctttgca gcaaaccgta agttataagg atgagggaag     360
aagagtagag ggccaaaagg attccatttt gaggaaaaac tacagtttgc cttgccaggt     420
agaagaatca ggcgcccaga caccatgtca caaccctcca gaactgacgt tggcaggaag     480
tagagacttt gttgcctgtg tcccccatcc tcaccatgtc ttcgactcag gacaatgggg     540
aacactggaa gtccctggag tctgtgggca tcagccgcaa agaactagcg atggccgaag     600
ccctgcagat ggagtatgat gccctgtccc ggctccggca tgacaaggag gagaacagag     660
ccaagcagaa cgcagacccc tctctcatca gctgggatga gcctggggta gacttttaca     720
gcaagccagc aggaaggcgg accgacctca agctgttacg cggtctctct ggctctgatc     780
ctacccttaa ctacaactca ctatccccac aggaagggcc gcccaaccac tctacctccc     840
aagggccaca gcctggctca gatccctggc ccaaaggctc cctgtctgga gactatctct     900
acatttttga tggttcagat gggggagtct cttcgtcccc aggaccaggg gacatagagg     960
gctcttgcaa gaaactatcc ccacctcctc tgcctccccg agcttctatc tgggataccc    1020
ctcccctgcc tcccagaaag gggtccccct catcctccaa gatctcccag cccagtgaca    1080
tcaacacttt ctctttggtc gaacaattgc caggcaaact gctagagcat cggatcctag    1140
aagaggaaga ggtgctggga ggtgggggtc aggggcgcct actggggtct gtggactatg    1200
atggtatcaa tgatgcaatt actaggctca acttgaaatc gacctatgat gtggagatgt    1260
tgcgggatgc caccaggggc tggaaggagg gccgagggcc gctggacttc agcaaagaca    1320
cctctggaaa acccgtggcc aggagcaaga ctatgccccc tcaggtgccc ccccgcacct    1380
atgcctcccg ctatggcaac cgaaagaatg cgacgcctgg caagaaccgc cggatttctg    1440
cagccccggt gggctcccgg ccccacactg ttgccaatgg ccatgagttg tttgaggtct    1500
cagaagagag agatgaggag gttgctgcat tttgccacat gctggatatc cttcgatctg    1560
gctctgacat ccaagactac ttcctcactg gctatgtctg gagtgctgtc acccctagcc    1620
cagagcacct cggggatgag gtcaacctga aggtgactgt gttgtgtgac aggcttcaag    1680
aggcactcac tttcacctgc aactgttcct ccactgtaga cttgcttatc taccagaccc    1740
tgtgctacac ccatgatgac ctgaggaatg tggacgtggg tgactttgtg ctaaagccct    1800
gcgggctgga ggagttcctg cagaacaagc atgccttggg cagtcatgag tacatccaat    1860
actgccgcaa gtttgacatt gacattcggc tacagctgat ggagcagaag gttgtgcgca    1920
gtgacctggc ccggacggtg aatgatgacc agagcccctc caccttgaac tacctcgtcc    1980
atctccaaga gaggcctgtc aagcagacca tcagcaggca ggccctgagt cttctgttcg    2040
acacttacca caatgaggtg gatgccttcc tgctggctga tggagacttc ccactgaagg    2100
ctgacagggt ggtccagtcc gtcaaggcca tctgcaacgc cctggccgcc gtggaaaccc    2160
ctgagatcac cagtgctctc aaccagctgc ccccctgccc ctcccgcatg cagcctaaaa    2220
ttcagaagga tcccagtgtc ttggctgtga gggaaaaccg agagaaggtc gtggaagccc    2280
tgaccgctgc catcttggac ctggtggagc tgtactgcaa cacattcaac gcagacttcc    2340
agacggcagt gcccgggagc cgcaagcatg acctggtcca ggaggcctgc catttcgcca    2400
ggtccctggc cttcactgtc tatgccaccc accgcatccc catcatctgg gctaccagct    2460
atgaagattt ctacctctcc tgctccctca gccatggcgg caaggacatg tgcagccccc    2520
tgcagacccg aagagctcac ttctccaagt acctcttcca cctcatcgtc tgggaccagc    2580
agatctgctt cccagtgcag gtgaaccggc tgcctcggga gacactgctg tgtgccactc    2640
tctatgctct gcccatcccc ccaccgggga gctcctcaga ggccaataag cagcggcggg    2700
tgcctgaagc cctgggctgg gtcactaccc cactcttcaa cttcaggcag gtcctgacct    2760
gtggccggaa gcttctgggt ttgtggccag caacacagga aaatcccagc gcccgttgga    2820
gtgcacctaa tttccaccag ccagacagtg tcatcctgca gattgacttc cccacctcgg    2880
cctttgacat caagttcacc agcccccctg gagacaagtt cagcccccgc tatgagtttg    2940
gcagcctccg ggaagaagac cagcgcaagc ttaaagacat catgcagaaa gagtccttgt    3000
actggctcac tgatgctgac aagaagcgcc tgtgggagaa gcgatattac tgccactcgg    3060
aggtgagctc gctccccctg gtgctcgcca gcgcccccag ctgggagtgg gcttgcctgc    3120
ctgacatcta tgttctcctg aagcagtgga cccacatgaa ccaccaggat gccctggggc    3180
tcctgcatgc caccttcccg gaccaggagg tgcgtcgtat ggctgtgcag tggattggct    3240
cactctcaga tgctgagctg ctagactacc tgccccagct ggtacaggcc ctgaagtatg    3300
aatgctacct ggacagcccg ttggtgcgct tcctcctgaa acgagctgtg tctgacttga    3360
gagtgactca ctacttcttc tggttactga aggacggcct caaggactct cagttcagca    3420
tccgctacca gtatctgctg gcagccttac tgtgctgctg tggcaagggg ctgagagaag    3480
agtttaaccg ccagtgctgg cttgtcaatg ccctggccaa actggcccag caggtccggg    3540
aggcagcccc atctgcaagg cagggaatcc tccgcacggg cctggaggag gtgaagcagt    3600
tctttgccct caatggctcg tgccgcttgc cactcagccc cagtctgctg gttaagggaa    3660
ttgtgcccag ggactgttcc tacttcaact ccaatgctgt ccccctcaaa ctctccttcc    3720
aaaatgtgga tcccctgggt gagaacatcc gtgtcatctt caagtgtggg gacgaccttc    3780
gccaggacat gctaacgctg cagatgattc gcatcatgag caagatctgg gtccaggagg    3840
ggctggacat gcgcatggtc atcttccgct gcttctccac cggccggggc agagggatgg    3900
tggagatgat ccctaatgct gagaccctgc gtaagatcca ggtggagcat ggggtgaccg    3960
gctcgttcaa ggaccggccc ctggcagact ggctgcagaa acacaaccct ggggaggacg    4020
agtatgagaa ggctgtggag aactttatct actcctgcgc tggctgctgc gtggccacgt    4080
acgtcttggg catctgtgac cgacataatg acaacatcat gctgaagacc actggtcaca    4140
tgttccacat tgattttggc cgcttcctgg gccatgccca gatgtttggc aacatcaagc    4200
gggaccgtgc cccctttgtc ttcacctcgg acatggcgta tgtcatcaac gggggtgaca    4260
agccttccag ccgcttccat gattttgttg acctttgctg ccaagcctac aacctcattc    4320
gcaagcacac ccacctcttc ctcaaccttc tgggcctgat gttgtcctgt gggatccctg    4380
aactctcaga cctggaggac ctcaagtatg tgtacgatgc cctgaggcct caggatacag    4440
aggccaatgc cactacctac ttcactaggt tgattgagtc cagcctgggc agtgtagcca    4500
caaagctcaa ttttttcatc cataatctgg ctcagatgaa gttcacgggc tcagatgacc    4560
ggctgaccct ctcctttgcc tcccgaacac acactctcaa gagctctggc cgaatcagtg    4620
atgttttcct ctgccgccat gagaagatct tccaccccaa caaaggctat atatatgtgg    4680
taaaggtgat gcgagagaac actcacgagg ccacctacat ccagcggacc tttgaggagt    4740
tccaggaatt acacaataag ttgcggctgc tcttcccttc ttcccacttg cccagcttcc    4800
ctagtcgctt cgtgatcggc cgctcccggg gagaggcggt ggccgagcgg cggagggagg    4860
agctaaacgg ttacatctgg cacttgatcc acgcaccccc tgaggtggcc gagtgtgatt    4920
tggtgtacac cttcttccac ccactgcccc gggatgagaa ggctatgggc accagcccag    4980
ctcctaagtc ctcagatggc acatgggccc ggcccgtcgg aaaggtggga ggggaggtga    5040
agctgtccat ctcctacaaa aacaataaac tcttcatcat ggtgatgcat attcggggct    5100
tgcaactgct ccaggatgga aatgaccctg acccctatgt gaaaatttac ctccttcctg    5160
accctcagaa aaccactaag aggaaaacca aagtggcccg gaaaacctgc aatcctacct    5220
acaatgagat gttggtatat gatgggatcc ccaagggtga cctgcagcag cgggagctcc    5280
agctgagcgt gctgagtgag cagggattct gggagaacgt cctcctcggt gaggtgaaca    5340
tccgcctgcg agagctggac ctggctcagg agaagaccgg ctggttcgcc ctgggatctc    5400
gaagtcatgg caccttgtga gcccagcaga gccaccaccc agcatcccag gctggtggca    5460
ggagctgggg gagaggactc tcccctgtga gactcctcct tgtgaagggc cagggccctg    5520
ggcaggcctc cagctcggtc caggtgattc tggcctctgt ggtaggaggc agggagagta    5580
agacatgctc tgctgtctct tcctctggag actgaacttg ggttggttgt gatgagcagc    5640
cccttggagg ctgtgaggtt gcagcaaagt tttaagttta ccttgtgtca agggagcaat    5700
gcttggtttg gggaatgtgt ggggtgggct gtatgaagta ccattttggg ggtgggtggg    5760
tggatatctt aatttttatt tttaaaaaat gaaatagtga tgttgtccta actgggacag    5820
gaagccttgc gagaagggac gtacctatgc cccacaaggc aagagaggaa cactatttgg    5880
actttttgta tgattaaggt tcttattgga cttttcccta ggtttttttt ttttgttatt    5940
gttgttgttg ttccgttttc tagctatagg aactatctgg ggaggggccc agtgggtcct    6000
cggccagagc cctctctaag gacaggttgg ggagggttgg ggagggctgc ctgtgctgga    6060
ctgaggcttg tgccactggg cctttctgat tttgcctcca aaggagagcg ctgtgatacc    6120
tacatgtgta aggaagggcc ttccgtattg gggttctgcc aaggacccgt attcagggac    6180
ccatgctctt ttggggggac ttttcctctt gtcttcccta ctttattagg acttgccctg    6240
aataccattt tctacccctt gcccctccat tctcctggcc cttctggggg tcagctggtc    6300
tctatgaata tgctgggggt gcttccccat aggtctctcc cttcatttgt ctctggtggg    6360
acaaaatact gactcagtcc ttagatgtag tttcacccaa gagcatcttg gccctgggaa    6420
gaggtcccta ggctgcagat gctactgact gcttgctagg tagcctctgg aaagcattcc    6480
ccatccatca ctccccactt ctttctgctg tgctgcttcc ctcccaaact ccatttctgt    6540
cacccttttt ataagacttt tcctcattct gtggggccat aaacctattt agtctggagc    6600
caaagggatg ccctatctga aggaaagggg catggggtgg gggattccat caaaactgtt    6660
gttttttgcc ccatgatttt tctttggtca gtaggaggct ggattggagt ggtgattatt    6720
cccctggagc taagctcagg agcccgaagg gagagactga gactgactcc cttatctctt    6780
catattcttt attccctacc agatggattt tttttttttt ttttggagac ggagtctcgc    6840
cctgtcgcca ggctggagtg tagtggcatg atctcgactc actgcaaaat ctgcctcccg    6900
ggttcaagcg attctcctac ctcagcctcc cgagtagctg ggattacagg catgtgccac    6960
cacgccaagc taatttttgt atttttagta gagacggggt ttcaccatgt tggccaggat    7020
ggtctcgatc tcttgacctc gtgatctgcc tgccttggcc tcccaaagtg ctgggattac    7080
aggcgtgagc caccatgccc cgccccagat ggattttaca tttgctcttt tgtgtttcgc    7140
tccaaagggt tgtcttcctc gccaaaagga gggagggact ttgaatttga tatgaatctt    7200
taaaaccaga attggctgga tatttcccat gattgggaaa agagtgaaat gaggacattc    7260
tgtaaactgt ccctccctaa ttccaaggat cagaaactcc ccgttttgct gactcattcc    7320
ataactggag aaagaagctc cattgaccga agccacaggg cagcatggaa gtttaaattt    7380
tctctaaaat taaaatgcca aggataaagc tggctgcttc caggaggggg aagaggagtg    7440
gggagtgggc ggtgaaactt ttccagatga acggaccata aatgtgttac tggctttgtg    7500
cctgtagctc attttattat gacctatatg ctcctgattt aaagagatct gtgtactgtt    7560
tacttcccac ttcccagaat cccttgtatc tcctttctcg ggaattgtat tttctaataa    7620
atgacatttg agaaaaaaaa aaaaaaaaaa aaaa                                7654


<210> 14
<211> 2511
<212> PRT
<213> Homo sapiens

<400> 14
Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser
 1               5                  10                  15
Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met
            20                  25                  30
Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro
        35                  40                  45
Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe
    50                  55                  60
Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg
65                  70                  75                  80
Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn
                85                  90                  95
Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser
            100                 105                 110
Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val
        115                 120                 125
Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu
    130                 135                 140
Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala
145                 150                 155                 160
Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His
                165                 170                 175
Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu
            180                 185                 190
Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro
        195                 200                 205
Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg
    210                 215                 220
Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg
225                 230                 235                 240
Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe
                245                 250                 255
Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu
            260                 265                 270
Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu
        275                 280                 285
Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu
    290                 295                 300
Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu
305                 310                 315                 320
Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser
                325                 330                 335
Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu
            340                 345                 350
Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala
        355                 360                 365
Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg
    370                 375                 380
Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val
385                 390                 395                 400
His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro
                405                 410                 415
His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu
            420                 425                 430
Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu
        435                 440                 445
Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala
    450                 455                 460
Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro
465                 470                 475                 480
Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys
                485                 490                 495
Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg
            500                 505                 510
Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys
        515                 520                 525
Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser
    530                 535                 540
Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln
545                 550                 555                 560
Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly
                565                 570                 575
Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly
            580                 585                 590
Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln
        595                 600                 605
Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly
    610                 615                 620
Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro
625                 630                 635                 640
Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala
                645                 650                 655
Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala
            660                 665                 670
Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu
        675                 680                 685
Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu
    690                 695                 700
Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala
705                 710                 715                 720
Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val
                725                 730                 735
Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val
            740                 745                 750
Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln
        755                 760                 765
Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu
    770                 775                 780
Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile
785                 790                 795                 800
Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe
                805                 810                 815
Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro
            820                 825                 830
Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu
        835                 840                 845
Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile
    850                 855                 860
Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu
865                 870                 875                 880
Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp
                885                 890                 895
Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val
            900                 905                 910
Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr
        915                 920                 925
Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe
    930                 935                 940
Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln
945                 950                 955                 960
Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr
                965                 970                 975
Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys
            980                 985                 990
Glu Leu Arg Leu Arg Gly Tyr Asp Tyr Gly Pro His Phe Gln Gly Ile
        995                 1000                1005
Leu Glu Ala Ser Leu Glu Gly Asp Ser Gly Arg Leu Leu Trp Lys Asp
    1010                1015                1020
Asn Trp Val Ser Phe Met Asp Thr Met Leu Gln Met Ser Ile Leu Gly
1025                1030                1035                1040
Ser Ala Lys His Gly Leu Tyr Leu Pro Thr Arg Val Thr Ala Ile His
                1045                1050                1055
Ile Asp Pro Ala Thr His Arg Gln Lys Leu Tyr Thr Leu Gln Asp Lys
            1060                1065                1070
Ala Gln Val Ala Asp Val Val Val Ser Arg Trp Leu Arg Val Thr Val
        1075                1080                1085
Ala Gly Gly Val His Ile Ser Gly Leu His Thr Glu Ser Ala Pro Arg
    1090                1095                1100
Arg Gln Gln Glu Gln Gln Val Pro Ile Leu Glu Lys Phe Cys Phe Thr
1105                1110                1115                1120
Pro His Thr Glu Glu Gly Cys Leu Ser Glu Arg Ala Ala Leu Gln Glu
                1125                1130                1135
Glu Leu Gln Leu Cys Lys Gly Leu Val Gln Ala Leu Gln Thr Lys Val
            1140                1145                1150
Thr Gln Gln Gly Leu Lys Met Val Val Pro Gly Leu Asp Gly Ala Gln
        1155                1160                1165
Ile Pro Arg Asp Pro Ser Gln Gln Glu Leu Pro Arg Leu Leu Ser Ala
    1170                1175                1180
Ala Cys Arg Leu Gln Leu Asn Gly Asn Leu Gln Leu Glu Leu Ala Gln
1185                1190                1195                1200
Val Leu Ala Gln Glu Arg Pro Lys Leu Pro Glu Asp Pro Leu Leu Ser
                1205                1210                1215
Gly Leu Leu Asp Ser Pro Ala Leu Lys Ala Cys Leu Asp Thr Ala Val
            1220                1225                1230
Glu Asn Met Pro Ser Leu Lys Met Lys Val Val Glu Val Leu Ala Gly
        1235                1240                1245
His Gly His Leu Tyr Ser Arg Ile Pro Gly Leu Leu Ser Pro His Pro
    1250                1255                1260
Leu Leu Gln Leu Ser Tyr Thr Ala Thr Asp Arg His Pro Gln Ala Leu
1265                1270                1275                1280
Glu Ala Ala Gln Ala Glu Leu Gln Gln His Asp Val Ala Gln Gly Gln
                1285                1290                1295
Trp Asp Pro Ala Asp Pro Ala Pro Ser Ala Leu Gly Ser Ala Asp Leu
            1300                1305                1310
Leu Val Cys Asn Cys Ala Val Ala Ala Leu Gly Asp Pro Ala Ser Ala
        1315                1320                1325
Leu Ser Asn Met Val Ala Ala Leu Arg Glu Gly Gly Phe Leu Leu Leu
    1330                1335                1340
His Thr Leu Leu Arg Gly His Pro Leu Gly Asp Ile Val Ala Phe Leu
1345                1350                1355                1360
Thr Ser Thr Glu Pro Gln Tyr Gly Gln Gly Ile Leu Ser Gln Asp Ala
                1365                1370                1375
Trp Glu Ser Leu Phe Ser Arg Val Ser Leu Arg Leu Val Gly Leu Lys
            1380                1385                1390
Lys Ser Phe Tyr Gly Ser Thr Leu Phe Leu Cys Arg Arg Pro Thr Pro
        1395                1400                1405
Gln Asp Ser Pro Ile Phe Leu Pro Val Asp Asp Thr Ser Phe Arg Trp
    1410                1415                1420
Val Glu Ser Leu Lys Gly Ile Leu Ala Asp Glu Asp Ser Ser Arg Pro
1425                1430                1435                1440
Val Trp Leu Lys Ala Ile Asn Cys Ala Thr Ser Gly Val Val Gly Leu
                1445                1450                1455
Val Asn Cys Leu Arg Arg Glu Pro Gly Gly Asn Arg Leu Arg Cys Val
            1460                1465                1470
Leu Leu Ser Asn Leu Ser Ser Thr Ser His Val Pro Glu Val Asp Pro
        1475                1480                1485
Gly Ser Ala Glu Leu Gln Lys Val Leu Gln Gly Asp Leu Val Met Asn
    1490                1495                1500
Val Tyr Arg Asp Gly Ala Trp Gly Ala Phe Arg His Phe Leu Leu Glu
1505                1510                1515                1520
Glu Asp Lys Pro Glu Glu Pro Thr Ala His Ala Phe Val Ser Thr Leu
                1525                1530                1535
Thr Arg Gly Asp Leu Ser Ser Ile Arg Trp Val Cys Ser Ser Leu Arg
            1540                1545                1550
His Ala Gln Pro Thr Cys Pro Gly Ala Gln Leu Cys Thr Val Tyr Tyr
        1555                1560                1565
Ala Ser Leu Asn Phe Arg Asp Ile Met Leu Ala Thr Gly Lys Leu Ser
    1570                1575                1580
Pro Asp Ala Ile Pro Gly Lys Trp Thr Ser Gln Asp Ser Leu Leu Gly
1585                1590                1595                1600
Met Glu Phe Ser Gly Arg Asp Ala Ser Gly Lys Arg Val Met Gly Leu
                1605                1610                1615
Val Pro Ala Lys Gly Leu Ala Thr Ser Val Leu Leu Ser Pro Asp Phe
            1620                1625                1630
Leu Trp Asp Val Pro Ser Asn Trp Thr Leu Glu Glu Ala Ala Ser Val
        1635                1640                1645
Pro Val Val Tyr Ser Thr Ala Tyr Tyr Ala Leu Val Val Arg Gly Arg
    1650                1655                1660
Val Arg Pro Gly Glu Thr Leu Leu Ile His Ser Gly Ser Gly Gly Val
1665                1670                1675                1680
Gly Gln Ala Ala Ile Ala Ile Ala Leu Ser Leu Gly Cys Arg Val Phe
                1685                1690                1695
Thr Thr Val Gly Ser Ala Glu Lys Arg Ala Tyr Leu Gln Ala Arg Phe
            1700                1705                1710
Pro Gln Leu Asp Ser Thr Ser Phe Ala Asn Ser Arg Asp Thr Ser Phe
        1715                1720                1725
Glu Gln His Val Leu Trp His Thr Gly Gly Lys Gly Val Asp Leu Val
    1730                1735                1740
Leu Asn Ser Leu Ala Glu Glu Lys Leu Gln Ala Ser Val Arg Cys Leu
1745                1750                1755                1760
Ala Thr His Gly Arg Phe Leu Glu Ile Gly Lys Phe Asp Leu Ser Gln
                1765                1770                1775
Asn His Pro Leu Gly Met Ala Ile Phe Leu Lys Asn Val Thr Phe His
            1780                1785                1790
Gly Val Leu Leu Asp Ala Phe Phe Asn Glu Ser Ser Ala Asp Trp Arg
        1795                1800                1805
Glu Val Trp Ala Leu Val Gln Ala Gly Ile Arg Asp Gly Val Val Arg
    1810                1815                1820
Pro Leu Lys Cys Thr Val Phe His Gly Ala Gln Val Glu Asp Ala Phe
1825                1830                1835                1840
Arg Tyr Met Ala Gln Gly Lys His Ile Gly Lys Val Val Val Gln Val
                1845                1850                1855
Leu Ala Glu Glu Pro Glu Ala Val Leu Lys Gly Ala Lys Pro Lys Leu
            1860                1865                1870
Met Ser Ala Ile Ser Lys Thr Phe Cys Pro Ala His Lys Ser Tyr Ile
        1875                1880                1885
Ile Ala Gly Gly Leu Gly Gly Phe Gly Leu Glu Leu Ala Gln Trp Leu
    1890                1895                1900
Ile Gln Arg Gly Val Gln Lys Leu Val Leu Thr Ser Arg Ser Gly Ile
1905                1910                1915                1920
Arg Thr Gly Tyr Gln Ala Lys Gln Val Arg Arg Trp Arg Arg Gln Gly
                1925                1930                1935
Val Gln Val Gln Val Ser Thr Ser Asn Ile Ser Ser Leu Glu Gly Ala
            1940                1945                1950
Arg Gly Leu Ile Ala Glu Ala Ala Gln Leu Gly Pro Val Gly Gly Val
        1955                1960                1965
Phe Asn Leu Ala Val Val Leu Arg Asp Gly Leu Leu Glu Asn Gln Thr
    1970                1975                1980
Pro Glu Phe Phe Gln Asp Val Cys Lys Pro Lys Tyr Ser Gly Thr Leu
1985                1990                1995                2000
Asn Leu Asp Arg Val Thr Arg Glu Ala Cys Pro Glu Leu Asp Tyr Phe
                2005                2010                2015
Val Val Phe Ser Ser Val Ser Cys Gly Arg Gly Asn Ala Gly Gln Ser
            2020                2025                2030
Asn Tyr Gly Phe Ala Asn Ser Ala Met Glu Arg Ile Cys Glu Lys Arg
        2035                2040                2045
Arg His Glu Gly Leu Pro Gly Leu Ala Val Gln Trp Gly Ala Ile Gly
    2050                2055                2060
Asp Val Gly Ile Leu Val Glu Thr Met Ser Thr Asn Asp Thr Ile Val
2065                2070                2075                2080
Ser Gly Thr Leu Pro Gln Arg Met Ala Ser Cys Leu Glu Val Leu Asp
                2085                2090                2095
Leu Phe Leu Asn Gln Pro His Met Val Leu Ser Ser Phe Val Leu Ala
            2100                2105                2110
Glu Lys Ala Ala Ala Tyr Arg Asp Arg Asp Ser Gln Arg Asp Leu Val
        2115                2120                2125
Glu Ala Val Ala His Ile Leu Gly Ile Arg Asp Leu Ala Ala Val Asn
    2130                2135                2140
Leu Asp Ser Ser Leu Ala Asp Leu Gly Leu Asp Ser Leu Met Ser Val
2145                2150                2155                2160
Glu Val Arg Gln Thr Leu Glu Arg Glu Leu Asn Leu Val Leu Ser Val
                2165                2170                2175
Arg Glu Val Arg Gln Leu Thr Leu Arg Lys Leu Gln Glu Leu Ser Ser
            2180                2185                2190
Lys Ala Asp Glu Ala Ser Glu Leu Ala Cys Pro Thr Pro Lys Glu Asp
        2195                2200                2205
Gly Leu Ala Gln Gln Gln Thr Gln Leu Asn Leu Arg Ser Leu Leu Val
    2210                2215                2220
Asn Pro Glu Gly Pro Thr Leu Met Arg Leu Asn Ser Val Gln Ser Ser
2225                2230                2235                2240
Glu Arg Pro Leu Phe Leu Val His Pro Ile Glu Gly Ser Thr Thr Val
                2245                2250                2255
Phe His Ser Leu Ala Ser Arg Leu Ser Ile Pro Thr Tyr Gly Leu Gln
            2260                2265                2270
Cys Thr Arg Ala Ala Pro Leu Asp Ser Ile His Ser Leu Ala Ala Tyr
        2275                2280                2285
Tyr Ile Asp Cys Ile Arg Gln Val Gln Pro Glu Gly Pro Tyr Arg Val
    2290                2295                2300
Ala Gly Tyr Ser Tyr Gly Ala Cys Val Ala Phe Glu Met Cys Ser Gln
2305                2310                2315                2320
Leu Gln Ala Gln Gln Ser Pro Ala Pro Thr His Asn Ser Leu Phe Leu
                2325                2330                2335
Phe Asp Gly Ser Pro Thr Tyr Val Leu Ala Tyr Thr Gln Ser Tyr Arg
            2340                2345                2350
Ala Lys Leu Thr Pro Gly Cys Glu Ala Glu Ala Glu Thr Glu Ala Ile
        2355                2360                2365
Cys Phe Phe Val Gln Gln Phe Thr Asp Met Glu His Asn Arg Val Leu
    2370                2375                2380
Glu Ala Leu Leu Pro Leu Lys Gly Leu Glu Glu Arg Val Ala Ala Ala
2385                2390                2395                2400
Val Asp Leu Ile Ile Lys Ser His Gln Gly Leu Asp Arg Gln Glu Leu
                2405                2410                2415
Ser Phe Ala Ala Arg Ser Phe Tyr Tyr Lys Leu Arg Ala Ala Glu Gln
            2420                2425                2430
Tyr Thr Pro Lys Ala Lys Tyr His Gly Asn Val Met Leu Leu Arg Ala
        2435                2440                2445
Lys Thr Gly Gly Ala Tyr Gly Glu Asp Leu Gly Ala Asp Tyr Asn Leu
    2450                2455                2460
Ser Gln Val Cys Asp Gly Lys Val Ser Val His Val Ile Glu Gly Asp
2465                2470                2475                2480
His Arg Thr Leu Leu Glu Gly Ser Gly Leu Glu Ser Ile Ile Ser Ile
                2485                2490                2495
Ile His Ser Ser Leu Ala Glu Pro Arg Val Ser Val Arg Glu Gly
            2500                2505                2510

<210> 15
<211> 8464
<212> DNA
<213> Homo sapiens

<400> 15
gagccagaga gacggcagcg gccccggcct ccctctccgc cgcgcttcag cctcccgctc      60
cgccgcgctc cagcctcgct ctccgccgcc cgcaccgccg cccgcgccct caccagagca     120
gccatggagg aggtggtgat tgccggcatg tccgggaagc tgccagagtc ggagaacttg     180
caggagttct gggacaacct catcggcggt gtggacatgg tcacggacga tgaccgtcgc     240
tggaaggcgg ggctctacgg cctgccccgg cggtccggca agctgaagga cctgtctagg     300
tttgatgcct ccttcttcgg agtccacccc aagcaggcac acacgatgga ccctcagctg     360
cggctgctgc tggaagtcac ctatgaagcc atcgtggacg gaggcatcaa cccagattca     420
ctccgaggaa cacacactgg cgtctgggtg ggcgtgagcg gctctgagac ctcggaggcc     480
ctgagccgag accccgagac actcgtgggc tacagcatgg tgggctgcca gcgagcgatg     540
atggccaacc ggctctcctt cttcttcgac ttcagagggc ccagcatcgc actggacaca     600
gcctgctcct ccagcctgat ggccctgcag aacgcctacc aggccatcca cagcgggcag     660
tgccctgccg ccatcgtggg gggcatcaat gtcctgctga agcccaacac ctccgtgcag     720
ttcttgaggc tggggatgct cagccccgag ggcacctgca aggccttcga cacagcgggg     780
aatgggtact gccgctcgga gggtgtggtg gccgtcctgc tgaccaagaa gtccctggcc     840
cggcgggtgt acgccaccat cctgaacgcc ggcaccaata cagatggctt caaggagcaa     900
ggcgtgacct tcccctcagg ggatatccag gagcagctca tccgctcgtt gtaccagtcg     960
gccggagtgg cccctgagtc atttgaatac atcgaagccc acggcacagg caccaaggtg    1020
ggcgaccccc aggagctgaa tggcatcacc cgagccctgt gcgccacccg ccaggagccg    1080
ctgctcatcg gctccaccaa gtccaacatg gggcacccgg agccagcctc ggggctggca    1140
gccctggcca aggtgctgct gtccctggag cacgggctct gggcccccaa cctgcacttc    1200
catagcccca accctgagat cccagcgctg ttggatgggc ggctgcaggt ggtggaccag    1260
cccctgcccg tccgtggcgg caacgtgggc atcaactcct ttggcttcgg gggctccaac    1320
gtgcacatca tcctgaggcc caacacgcag ccgccccccg cacccgcccc acatgccacc    1380
ctgccccgtc tgctgcgggc cagcggacgc acccctgagg ccgtgcagaa gctgctggag    1440
cagggcctcc ggcacagcca ggacctggct ttcctgagca tgctgaacga catcgcggct    1500
gtccccgcca ccgccatgcc cttccgtggc tacgctgtgc tgggtggtga gcgcggtggc    1560
ccagaggtgc agcaggtgcc cgctggcgag cgcccgctct ggttcatctg ctctgggatg    1620
ggcacacagt ggcgcgggat ggggctgagc ctcatgcgcc tggaccgctt ccgagattcc    1680
atcctacgct ccgatgaggc tgtgaagcca ttcggcctga aggtgtcaca gctgctgctg    1740
agcacagacg agagcacctt tgatgacatc gtccattcgt ttgtgagcct gactgccatc    1800
cagataggcc tcatagacct gctgagctgc atggggctga ggccagatgg catcgtcggc    1860
cactccctgg gggaggtggc ctgtggctac gccgacggct gcctgtccca ggaggaggcc    1920
gtcctcgctg cctactggag gggacagtgc atcaaagaag cccatctccc gccgggcgcc    1980
atggcagccg tgggcttgtc ctgggaggag tgtaaacagc gctgcccccc gggcgtggtg    2040
cccgcctgcc acaactccaa ggacacagtc accatctcgg gacctcaggc cccggtgttt    2100
gagttcgtgg agcagctgag gaaggagggt gtgtttgcca aggaggtgcg gaccggcggt    2160
atggccttcc actcctactt catggaggcc atcgcacccc cactgctgca ggagctcaag    2220
aaggtgatcc gggagccgaa gccacgttca gcccgctggc tcagcacctc tatccccgag    2280
gcccagtggc acagcagcct ggcacgcacg tcctccgccg agtacaatgt caacaacctg    2340
gtgagccctg tgctgttcca ggaggccctg tggcacgtgc ctgagcacgc ggtggtgctg    2400
gagatcgcgc cccacgccct gctgcaggct gtcctgaagc gtggcctgaa gccgagctgc    2460
accatcatcc ccctgatgaa gaaggatcac agggacaacc tggagttctt cctggccggc    2520
atcggcaggc tgcacctctc aggcatcgac gccaacccca atgccttgtt cccacctgtg    2580
gagttcccag ctccccgagg aactcccctc atctccccac tcatcaagtg ggaccacagc    2640
ctggcctggg acgtgccggc cgccgaggac ttccccaacg gttcaggttc cccctcagcc    2700
gccatctaca acatcgacac cagctccgag tctcctgacc actacctggt ggaccacacc    2760
ctcgacggtc gcgtcctctt ccccgccact ggctacctga gcatagtgtg gaagacgctg    2820
gcccgcgccc tgggcctggg cgtcgagcag ctgcctgtgg tgtttgagga tgtggtgctg    2880
caccaggcca ccatcctgcc caagactggg acagtgtccc tggaggtacg gctcctggag    2940
gcctcccgtg ccttcgaggt gtcagagaac ggcaacctgg tagtgagtgg gaaggtgtac    3000
cagtgggatg accctgaccc caggctcttc gaccacccgg aaagccccac ccccaacccc    3060
acggagcccc tcttcctggc ccaggctgaa gtttacaagg agctgcgtct gcgtggctac    3120
gactacggcc ctcatttcca gggcatcctg gaggccagcc tggaaggtga ctcggggagg    3180
ctgctgtgga aggataactg ggtgagcttc atggacacca tgctgcagat gtccatcctg    3240
ggctcggcca agcacggcct gtacctgccc acccgtgtca ccgccatcca catcgaccct    3300
gccacccaca ggcagaagct gtacacactg caggacaagg cccaagtggc tgacgtggtg    3360
gtgagcaggt ggctgagggt cacagtggcc ggaggcgtcc acatctccgg gctccacact    3420
gagtcggccc cgcggcggca gcaggagcag caggtgccca tcctggagaa gttttgcttc    3480
actccccaca cggaggaggg gtgcctgtct gagcgcgctg ccctgcagga ggagctgcaa    3540
ctgtgcaagg ggctggtgca ggcactgcag accaaggtga cccagcaggg gctgaagatg    3600
gtggtgcccg gactggatgg ggcccagatc ccccgggacc cctcacagca ggaactgccc    3660
cggctgttgt cggctgcctg caggcttcag ctcaacggga acctgcagct ggagctggcg    3720
caggtgctgg cccaggagag gcccaagctg ccagaggacc ctctgctcag cggcctcctg    3780
gactccccgg cactcaaggc ctgcctggac actgccgtgg agaacatgcc cagcctgaag    3840
atgaaggtgg tggaggtgct ggctggccac ggtcacctgt attcccgcat cccaggcctg    3900
ctcagccccc atcccctgct gcagctgagc tacacggcca ccgaccgcca cccccaggcc    3960
ctggaggctg cccaggccga gctgcagcag cacgacgttg cccagggcca gtgggatccc    4020
gcagaccctg cccccagcgc cctgggcagc gccgacctcc tggtgtgcaa ctgtgctgtg    4080
gctgccctcg gggacccggc ctcagctctc agcaacatgg tggctgccct gagagaaggg    4140
ggctttctgc tcctgcacac actgctccgg gggcaccccc tcggggacat cgtggccttc    4200
ctcacctcca ctgagccgca gtatggccag ggcatcctga gccaggacgc gtgggagagc    4260
ctcttctcca gggtgtcgct gcgcctggtg ggcctgaaga agtccttcta cggctccacg    4320
ctcttcctgt gccgccggcc caccccgcag gacagcccca tcttcctgcc ggtggacgat    4380
accagcttcc gctgggtgga gtctctgaag ggcatcctgg ctgacgaaga ctcttcccgg    4440
cctgtgtggc tgaaggccat caactgtgcc acctcgggcg tggtgggctt ggtgaactgt    4500
ctccgccgag agcccggcgg gaaccgcctc cggtgtgtgc tgctctccaa cctcagcagc    4560
acctcccacg tcccggaggt ggacccgggc tccgcagaac tgcagaaggt gttgcaggga    4620
gacctggtga tgaacgtcta ccgcgacggg gcctgggggg ctttccgcca cttcctgctg    4680
gaggaggaca agcctgagga gccgacggca catgcctttg tgagcaccct cacccggggg    4740
gacctgtcct ccatccgctg ggtctgctcc tcgctgcgcc atgcccagcc cacctgccct    4800
ggcgcccagc tctgcacggt ctactacgcc tccctcaact tccgcgacat catgctggcc    4860
actggcaagc tgtcccctga tgccatccca gggaagtgga cctcccagga cagcctgcta    4920
ggtatggagt tctcgggccg agacgccagc ggcaagcgtg tgatgggact ggtgcctgcc    4980
aagggcctgg ccacctctgt cctgctgtca ccggacttcc tctgggatgt gccttccaac    5040
tggacgctgg aggaggcggc ctcggtgcct gtcgtctaca gcacggccta ctacgcgctg    5100
gtggtgcgtg ggcgggtgcg ccccggggag acgctgctca tccactcggg ctcgggcggc    5160
gtgggccagg ccgccatcgc catcgccctc agtctgggct gccgcgtctt caccaccgtg    5220
gggtcggctg agaagcgggc gtacctccag gccaggttcc cccagctcga cagcaccagc    5280
ttcgccaact cccgggacac atccttcgag cagcatgtgc tgtggcacac gggcgggaag    5340
ggcgttgacc tggtcttgaa ctccttggcg gaagagaagc tgcaggccag cgtgaggtgc    5400
ttggctacgc acggtcgctt cctggaaatt ggcaaattcg acctttctca gaaccacccg    5460
ctcggcatgg ctatcttcct gaagaacgtg acattccacg gggtcctact ggatgcgttc    5520
ttcaacgaga gcagtgctga ctggcgggag gtgtgggcgc ttgtgcaggc cggcatccgg    5580
gatggggtgg tacggcccct caagtgcacg gtgttccatg gggcccaggt ggaggacgcc    5640
ttccgctaca tggcccaagg gaagcacatt ggcaaagtcg tcgtgcaggt gcttgcggag    5700
gagccggagg cagtgctgaa gggggccaaa cccaagctga tgtcggccat ctccaagacc    5760
ttctgcccgg cccacaagag ctacatcatc gctggtggtc tgggtggctt cggcctggag    5820
ttggcgcagt ggctgataca gcgtggggtg cagaagctcg tgttgacttc tcgctccggg    5880
atccggacag gctaccaggc caagcaggtc cgccggtgga ggcgccaggg cgtacaggtg    5940
caggtgtcca ccagcaacat cagctcactg gagggggccc ggggcctcat tgccgaggcg    6000
gcgcagcttg ggcccgtggg cggcgtcttc aacctggccg tggtcttgag agatggcttg    6060
ctggagaacc agaccccaga gttcttccag gacgtctgca agcccaagta cagcggcacc    6120
ctgaacctgg acagggtgac ccgagaggcg tgccctgagc tggactactt tgtggtcttc    6180
tcctctgtga gctgcgggcg tggcaatgcg ggacagagca actacggctt tgccaattcc    6240
gccatggagc gtatctgtga gaaacgccgg cacgaaggcc tcccaggcct ggccgtgcag    6300
tggggcgcca tcggcgacgt gggcattttg gtggagacga tgagcaccaa cgacacgatc    6360
gtcagtggca cgctgcccca gcgcatggcg tcctgcctgg aggtgctgga cctcttcctg    6420
aaccagcccc acatggtcct gagcagcttt gtgctggctg agaaggctgc ggcctatagg    6480
gacagggaca gccagcggga cctggtggag gccgtggcac acatcctggg catccgcgac    6540
ttggctgctg tcaacctgga cagctcactg gcggacctgg gcctggactc gctcatgagc    6600
gtggaggtgc gccagacgct ggagcgtgag ctcaacctgg tgctgtccgt gcgcgaggtg    6660
cggcaactca cgctccggaa actgcaggag ctgtcctcaa aggcggatga ggccagcgag    6720
ctggcatgcc ccacgcccaa ggaggatggt ctggcccagc agcagactca gctgaacctg    6780
cgctccctgc tggtgaaccc ggagggcccc accctgatgc ggctcaactc cgtgcagagc    6840
tcggagcggc ccctgttcct ggtgcaccca atcgagggct ccaccaccgt gttccacagc    6900
ctggcctccc ggctcagcat ccccacctat ggcctgcagt gcacccgagc tgcgcccctt    6960
gacagcatcc acagcctggc tgcctactac atcgactgca tcaggcaggt gcagcccgag    7020
ggcccctacc gcgtggccgg ctactcctac ggggcctgcg tggcctttga aatgtgctcc    7080
cagctgcagg cccagcagag cccagccccc acccacaaca gcctcttcct gttcgacggc    7140
tcgcccacct acgtactggc ctacacccag agctaccggg caaagctgac cccaggctgt    7200
gaggctgagg ctgagacgga ggccatatgc ttcttcgtgc agcagttcac ggacatggag    7260
cacaacaggg tgctggaggc gctgctgccg ctgaagggcc tagaggagcg tgtggcagcc    7320
gccgtggacc tgatcatcaa gagccaccag ggcctggacc gccaggagct gagctttgcg    7380
gcccggtcct tctactacaa gctgcgtgcc gctgagcagt acacacccaa ggccaagtac    7440
catggcaacg tgatgctact gcgcgccaag acgggtggcg cctacggcga ggacctgggc    7500
gcggactaca acctctccca ggtatgcgac gggaaagtat ccgtccacgt catcgagggt    7560
gaccaccgca cgctgctgga gggcagcggc ctggagtcca tcatcagcat catccacagc    7620
tccctggctg agccacgcgt gagcgtgcgg gagggctagg cccgtgcccc cgcctgccac    7680
cggaggtcac tccaccatcc ccaccccacc ccaccccacc cccgccatgc aacgggattg    7740
aagggtcctg ccggtgggac cctgtccggc ccagtgccac tgccccccga ggctgctaga    7800
tgtaggtgtt aggcatgtcc cacccacccg ccgcctccca cggcacctcg gggacaccag    7860
agctgccgac ttggagactc ctggtctgtg aagagccggt ggtgcccgtg cccgcaggaa    7920
ctgggctggg cctcgtgcgc ccgtggggtc tgcgcttggt ctttctgtgc ttggatttgc    7980
atatttattg cattgctggt agagaccccc aggcctgtcc accctgccaa gactcctcag    8040
gcagcgtgtg ggtcccgcac tctgccccca tttccccgat gtcccctgcg ggcgcgggca    8100
gccacccaag cctgctggct gcggccccct ctcggccagg cattggctca gcccgctgag    8160
tggggggtcg tgggccagtc cccgaggagc tgggcccctg cacaggcaca cagggcccgg    8220
ccacacccag cggccccccg cacagccacc cgtggggtgc tgcccttatg cccggcgccg    8280
ggcaccaact ccatgtttgg tgtttgtctg tgtttgtttt tcaagaaatg attcaaattg    8340
ctgcttggat tttgaaattt actgtaactg tcagtgtaca cgtctggacc ccgtttcatt    8400
tttacaccaa tttggtaaaa atgctgctct cagcctccca caattaaacc gcatgtgatc    8460
tcca

<210> 16
<211> 2683
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Ser Ser Gly Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu
 1               5                  10                  15
Asn Leu Asp Ser Ser Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met
            20                  25                  30
Ser Leu Arg Ser Tyr Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser
        35                  40                  45
Gly Glu Cys Ser Pro Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe
    50                  55                  60
Val Asn Gly Ser Arg Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys
65                  70                  75                  80
Glu Arg Ser Leu Leu Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys
                85                  90                  95
Asp Trp Tyr Tyr Ala Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser
            100                 105                 110
Leu Pro Leu Thr Glu Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg
        115                 120                 125
Gln Leu Glu Tyr Glu Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln
    130                 135                 140
Leu Gly Thr Cys Gln Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala
145                 150                 155                 160
Arg Ile Gln Gln Ile Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu
                165                 170                 175
Gln Ser Gln Ala Thr Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu
            180                 185                 190
Thr Gly Ser His Asp Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly
        195                 200                 205
Glu Ile Asn Met Ala Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg
    210                 215                 220
Met Asp His Glu Thr Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser
225                 230                 235                 240
Ala Pro Arg Arg Leu Thr Ser His Leu Gly Thr Lys Ile Arg Ala Tyr
                245                 250                 255
Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp
            260                 265                 270
Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro
        275                 280                 285
Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His
    290                 295                 300
Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln
305                 310                 315                 320
Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr
                325                 330                 335
Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp
            340                 345                 350
Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala
        355                 360                 365
Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile
    370                 375                 380
Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys
385                 390                 395                 400
Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala
                405                 410                 415
Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu
            420                 425                 430
Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala
        435                 440                 445
Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser
    450                 455                 460
Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg
465                 470                 475                 480
Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu
                485                 490                 495
Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His
            500                 505                 510
Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser
        515                 520                 525
Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val
    530                 535                 540
Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met
545                 550                 555                 560
Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys
                565                 570                 575
Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu
            580                 585                 590
His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His
        595                 600                 605
Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser
    610                 615                 620
His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val
625                 630                 635                 640
Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr
                645                 650                 655
Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro
            660                 665                 670
Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys
        675                 680                 685
Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His
    690                 695                 700
Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile
705                 710                 715                 720
Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala
                725                 730                 735
Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu
            740                 745                 750
His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala
        755                 760                 765
His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn
    770                 775                 780
Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser
785                 790                 795                 800
Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg
                805                 810                 815
Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser
            820                 825                 830
Lys Phe Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile
        835                 840                 845
His Ser Ala Asn His Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro
    850                 855                 860
Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg
865                 870                 875                 880
Gln Ser Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile
                885                 890                 895
Glu Asp Glu Ile Lys Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser
            900                 905                 910
Thr Thr Tyr Pro Val Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys
        915                 920                 925
Phe Gln Pro His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser
    930                 935                 940
Arg Gly Ala Asn Gly Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly
945                 950                 955                 960
Ile Asn Gln Asn Val Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu
                965                 970                 975
Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln
            980                 985                 990
His Glu Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu
        995                 1000                1005
Glu Lys Arg His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala
    1010                1015                1020
Thr Asp Ile Pro Ser Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser
1025                1030                1035                1040
Ser Ser Gly Gln Ser Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu
                1045                1050                1055
Asn Thr Ser Thr Pro Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His
            1060                1065                1070
Pro Ser Ser Ala Gln Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr
        1075                1080                1085
Cys Lys Val Ser Ser Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val
    1090                1095                1100
Glu Asp Thr Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu
1105                1110                1115                1120
Ser Ser Ala Glu Asp Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala
                1125                1130                1135
Asp Ser Ala Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly
            1140                1145                1150
Thr Arg Ser Ala Glu Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln
        1155                1160                1165
His Pro Arg Thr Lys Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser
    1170                1175                1180
Glu Ser Ala Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser
1185                1190                1195                1200
Pro Ser Lys Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr
                1205                1210                1215
Val Gln Glu Thr Pro Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser
            1220                1225                1230
Leu Asp Ser Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu
        1235                1240                1245
Pro Cys Ser Gly Met Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro
    1250                1255                1260
Asp Ser Pro Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro
1265                1270                1275                1280
Pro Pro Pro Gln Thr Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys
                1285                1290                1295
Ala Pro Thr Ala Glu Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val
            1300                1305                1310
Asn Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu
        1315                1320                1325
Leu His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser
    1330                1335                1340
Ser Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val
1345                1350                1355                1360
Glu Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu
                1365                1370                1375
Thr Glu Ser Glu Gln Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu
            1380                1385                1390
Ala Glu Lys Thr Ile Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp
        1395                1400                1405
Asp Asp Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro
    1410                1415                1420
Thr Lys Ser Ser Arg Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys
1425                1430                1435                1440
Leu Pro Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys
                1445                1450                1455
Leu Leu Pro Ser Gln Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe
            1460                1465                1470
Thr Pro Gly Asp Asp Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro
        1475                1480                1485
Ile Asn Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser
    1490                1495                1500
Pro Pro Asn Glu Leu Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln
1505                1510                1515                1520
Ser Gly Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser
                1525                1530                1535
Thr Asp Glu Ala Gln Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu
            1540                1545                1550
Leu Asp Asp Asn Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile
        1555                1560                1565
Asn Ser Ala Met Pro Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys
    1570                1575                1580
Lys Ile Met Asp Gln Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro
1585                1590                1595                1600
Asn Lys Asn Gln Leu Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val
                1605                1610                1615
Lys Pro Ile Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn
            1620                1625                1630
Ala Asp Ser Lys Asn Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn
        1635                1640                1645
Lys Asp Ser Lys Lys Gln Asn Leu Lys Asn Asn Ser Lys Val Phe Asn
    1650                1655                1660
Asp Lys Leu Pro Asn Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe
1665                1670                1675                1680
Asp Ser Pro His His Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe
                1685                1690                1695
Ser Arg Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val
            1700                1705                1710
Asp Leu Ser Arg Glu Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys
        1715                1720                1725
Glu Ser Glu Ala Lys Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln
    1730                1735                1740
Gln Ser Ala Asn Lys Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg
1745                1750                1755                1760
Gly Gln Pro Lys Pro Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser
                1765                1770                1775
Ser Lys Asp Ile Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln
            1780                1785                1790
Asn Phe Ala Ile Glu Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser
        1795                1800                1805
Leu Ser Ser Leu Ser Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn
    1810                1815                1820
Glu Pro Ile Lys Glu Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser
1825                1830                1835                1840
Lys Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp
                1845                1850                1855
Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile
            1860                1865                1870
Asp Ser Glu Asp Asp Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro
        1875                1880                1885
Lys Lys Lys Lys Pro Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser
    1890                1895                1900
Pro Arg Asn Met Gly Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu
1905                1910                1915                1920
Lys Asp Ile Gln Arg Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser
                1925                1930                1935
Glu Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val
            1940                1945                1950
Ser Ser Leu His Gln Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala
        1955                1960                1965
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu
    1970                1975                1980
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr
1985                1990                1995                2000
Ser Asn Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu
                2005                2010                2015
Glu Thr Lys Lys Ile Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys
            2020                2025                2030
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu
        2035                2040                2045
Ile Ser Gly Gln Met Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile
    2050                2055                2060
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser
2065                2070                2075                2080
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro
                2085                2090                2095
Ala Ser Lys Ser Pro Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg
            2100                2105                2110
Gly Ala Lys Pro Ser Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln
        2115                2120                2125
Thr Ser Gln Ile Gly Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser
    2130                2135                2140
Arg Asp Ser Thr Pro Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro
2145                2150                2155                2160
Ile Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile
                2165                2170                2175
Ser Pro Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser
            2180                2185                2190
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser
        2195                2200                2205
Pro Gly Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu
    2210                2215                2220
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly
2225                2230                2235                2240
Leu Asn Gln Met Asn Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu
                2245                2250                2255
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser
            2260                2265                2270
Glu Arg Pro Val Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro
        2275                2280                2285
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser
    2290                2295                2300
Leu Ser Pro Ser Ser Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln
2305                2310                2315                2320
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His
                2325                2330                2335
Ser Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser
            2340                2345                2350
Pro Thr Ile Glu Tyr Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile
        2355                2360                2365
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser
    2370                2375                2380
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg
2385                2390                2395                2400
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala
                2405                2410                2415
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val
            2420                2425                2430
Asn Ser Ile Ser Gly Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala
        2435                2440                2445
Lys Gly Thr Trp Arg Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn
    2450                2455                2460
Ser Thr Ser Gln Thr Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser
2465                2470                2475                2480
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp
                2485                2490                2495
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly
            2500                2505                2510
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu
        2515                2520                2525
Lys Ala Asn Pro Asn Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln
    2530                2535                2540
Asn Val Gly Asn Gly Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn
2545                2550                2555                2560
Arg Leu Asn Ser Phe Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr
                2565                2570                2575
Glu Ile Lys Pro Gly Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn
            2580                2585                2590
Glu Ser Ser Ile Val Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser
        2595                2600                2605
Lys His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe
    2610                2615                2620
Asn Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala
2625                2630                2635                2640
Arg Pro Ser Gln Ile Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg
                2645                2650                2655
Asp Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys
            2660                2665                2670
Arg His Ser Gly Ser Tyr Leu Val Thr Ser Val
        2675                2680

<210> 17
<211> 10248
<212> DNA
<213> Homo sapiens

<400> 17
actggagaca gaatggaggt gctgccggac tcggaaatgg ggaagtactt aaacaactac      60
aaggaagtat tgaagatgaa gctatggctt cttctggaca gattgattta ttagagcgtc     120
ttaaagagct taacttagat agcagtaatt tccctggagt aaaactgcgg tcaaaaatgt     180
ccctccgttc ttatggaagc cgggaaggat ctgtatcaag ccgttctgga gagtgcagtc     240
ctgttcctat gggttcattt ccaagaagag ggtttgtaaa tggaagcaga gaaagtactg     300
gatatttaga agaacttgag aaagagaggt cattgcttct tgctgatctt gacaaagaag     360
aaaaggaaaa agactggtat tacgctcaac ttcagaatct cactaaaaga atagatagtc     420
ttcctttaac tgaaaatttt tccttacaaa cagatatgac cagaaggcaa ttggaatatg     480
aagcaaggca aatcagagtt gcgatggaag aacaactagg tacctgccag gatatggaaa     540
aacgagcaca gcgaagaata gccagaattc agcaaatcga aaaggacata cttcgtatac     600
gacagctttt acagtcccaa gcaacagaag cagagaggtc atctcagaac aagcatgaaa     660
ccggctcaca tgatgctgag cggcagaatg aaggtcaagg agtgggagaa atcaacatgg     720
caacttctgg taatggtcag ggttcaacta cacgaatgga ccatgaaaca gccagtgttt     780
tgagttctag tagcacacac tctgcacctc gaaggctgac aagtcatctg ggaaccaaga     840
tacgcgctta ctgtgaaacc tgttgggagt ggcaggaagc tcatgaacca ggcatggacc     900
aggacaaaaa tccaatgcca gctcctgttg aacatcagat ctgtcctgct gtgtgtgttc     960
taatgaaact ttcatttgat gaagagcata gacatgcaat gaatgaacta gggggactac    1020
aggccattgc agaattattg caagtggact gtgaaatgta tgggcttact aatgaccact    1080
acagtattac actaagacga tatgctggaa tggctttgac aaacttgact tttggagatg    1140
tagccaacaa ggctacgcta tgctctatga aaggctgcat gagagcactt gtggcccaac    1200
taaaatctga aagtgaagac ttacagcagg ttattgcgag tgttttgagg aatttgtctt    1260
ggcgagcaga tgtaaatagt aaaaagacgt tgcgagaagt tggaagtgtg aaagcattga    1320
tggaatgtgc tttagaagtt aaaaaggaat caaccctcaa aagcgtattg agtgccttat    1380
ggaatttgtc agcacattgc actgagaata aagctgatat atgtgctgta gatggtgcac    1440
ttgcattttt ggttggcact cttacttacc ggagccagac aaacacttta gccattattg    1500
aaagtggagg tgggatatta cggaatgtgt ccagcttgat agctacaaat gaggaccaca    1560
ggcaaatcct aagagagaac aactgtctac aaactttatt acaacactta aaatctcata    1620
gtttgacaat agtcagtaat gcatgtggaa ctttgtggaa tctctcagca agaaatccta    1680
aagaccagga agcattatgg gacatggggg cagttagcat gctcaagaac ctcattcatt    1740
caaagcacaa aatgattgct atgggaagtg ctgcagcttt aaggaatctc atggcaaata    1800
ggcctgcgaa gtacaaggat gccaatatta tgtctcctgg ctcaagcttg ccatctcttc    1860
atgttaggaa acaaaaagcc ctagaagcag aattagatgc tcagcactta tcagaaactt    1920
ttgacaatat agacaattta agtcccaagg catctcatcg tagtaagcag agacacaagc    1980
aaagtctcta tggtgattat gtttttgaca ccaatcgaca tgatgataat aggtcagaca    2040
attttaatac tggcaacatg actgtccttt caccatattt gaatactaca gtgttaccca    2100
gctcctcttc atcaagagga agcttagata gttctcgttc tgaaaaagat agaagtttgg    2160
agagagaacg cggaattggt ctaggcaact accatccagc aacagaaaat ccaggaactt    2220
cttcaaagcg aggtttgcag atctccacca ctgcagccca gattgccaaa gtcatggaag    2280
aagtgtcagc cattcatacc tctcaggaag acagaagttc tgggtctacc actgaattac    2340
attgtgtgac agatgagaga aatgcactta gaagaagctc tgctgcccat acacattcaa    2400
acacttacaa tttcactaag tcggaaaatt caaataggac atgttctatg ccttatgcca    2460
aattagaata caagagatct tcaaatgata gtttaaatag tgtcagtagt agtgatggtt    2520
atggtaaaag aggtcaaatg aaaccctcga ttgaatccta ttctgaagat gatgaaagta    2580
agttttgcag ttatggtcaa tacccagccg acctagccca taaaatacat agtgcaaatc    2640
atatggatga taatgatgga gaactagata caccaataaa ttatagtctt aaatattcag    2700
atgagcagtt gaactctgga aggcaaagtc cttcacagaa tgaaagatgg gcaagaccca    2760
aacacataat agaagatgaa ataaaacaaa gtgagcaaag acaatcaagg aatcaaagta    2820
caacttatcc tgtttatact gagagcactg atgataaaca cctcaagttc caaccacatt    2880
ttggacagca ggaatgtgtt tctccataca ggtcacgggg agccaatggt tcagaaacaa    2940
atcgagtggg ttctaatcat ggaattaatc aaaatgtaag ccagtctttg tgtcaagaag    3000
atgactatga agatgataag cctaccaatt atagtgaacg ttactctgaa gaagaacagc    3060
atgaagaaga agagagacca acaaattata gcataaaata taatgaagag aaacgtcatg    3120
tggatcagcc tattgattat agtttaaaat atgccacaga tattccttca tcacagaaac    3180
agtcattttc attctcaaag agttcatctg gacaaagcag taaaaccgaa catatgtctt    3240
caagcagtga gaatacgtcc acaccttcat ctaatgccaa gaggcagaat cagctccatc    3300
caagttctgc acagagtaga agtggtcagc ctcaaaaggc tgccacttgc aaagtttctt    3360
ctattaacca agaaacaata cagacttatt gtgtagaaga tactccaata tgtttttcaa    3420
gatgtagttc attatcatct ttgtcatcag ctgaagatga aataggatgt aatcagacga    3480
cacaggaagc agattctgct aataccctgc aaatagcaga aataaaagaa aagattggaa    3540
ctaggtcagc tgaagatcct gtgagcgaag ttccagcagt gtcacagcac cctagaacca    3600
aatccagcag actgcagggt tctagtttat cttcagaatc agccaggcac aaagctgttg    3660
aattttcttc aggagcgaaa tctccctcca aaagtggtgc tcagacaccc aaaagtccac    3720
ctgaacacta tgttcaggag accccactca tgtttagcag atgtacttct gtcagttcac    3780
ttgatagttt tgagagtcgt tcgattgcca gctccgttca gagtgaacca tgcagtggaa    3840
tggtaagtgg cattataagc cccagtgatc ttccagatag ccctggacaa accatgccac    3900
caagcagaag taaaacacct ccaccacctc ctcaaacagc tcaaaccaag cgagaagtac    3960
ctaaaaataa agcacctact gctgaaaaga gagagagtgg acctaagcaa gctgcagtaa    4020
atgctgcagt tcagagggtc caggttcttc cagatgctga tactttatta cattttgcca    4080
cggaaagtac tccagatgga ttttcttgtt catccagcct gagtgctctg agcctcgatg    4140
agccatttat acagaaagat gtggaattaa gaataatgcc tccagttcag gaaaatgaca    4200
atgggaatga aacagaatca gagcagccta aagaatcaaa tgaaaaccaa gagaaagagg    4260
cagaaaaaac tattgattct gaaaaggacc tattagatga ttcagatgat gatgatattg    4320
aaatactaga agaatgtatt atttctgcca tgccaacaaa gtcatcacgt aaagcaaaaa    4380
agccagccca gactgcttca aaattacctc cacctgtggc aaggaaacca agtcagctgc    4440
ctgtgtacaa acttctacca tcacaaaaca ggttgcaacc ccaaaagcat gttagtttta    4500
caccggggga tgatatgcca cgggtgtatt gtgttgaagg gacacctata aacttttcca    4560
cagctacatc tctaagtgat ctaacaatcg aatcccctcc aaatgagtta gctgctggag    4620
aaggagttag aggaggggca cagtcaggtg aatttgaaaa acgagatacc attcctacag    4680
aaggcagaag tacagatgag gctcaaggag gaaaaacctc atctgtaacc atacctgaat    4740
tggatgacaa taaagcagag gaaggtgata ttcttgcaga atgcattaat tctgctatgc    4800
ccaaagggaa aagtcacaag cctttccgtg tgaaaaagat aatggaccag gtccagcaag    4860
catctgcgtc ttcttctgca cccaacaaaa atcagttaga tggtaagaaa aagaaaccaa    4920
cttcaccagt aaaacctata ccacaaaata ctgaatatag gacacgtgta agaaaaaatg    4980
cagactcaaa aaataattta aatgctgaga gagttttctc agacaacaaa gattcaaaga    5040
aacagaattt gaaaaataat tccaaggtct tcaatgataa gctcccaaat aatgaagata    5100
gagtcagagg aagttttgct tttgattcac ctcatcatta cacgcctatt gaaggaactc    5160
cttactgttt ttcacgaaat gattctttga gttctctaga ttttgatgat gatgatgttg    5220
acctttccag ggaaaaggct gaattaagaa aggcaaaaga aaataaggaa tcagaggcta    5280
aagttaccag ccacacagaa ctaacctcca accaacaatc agctaataag acacaagcta    5340
ttgcaaagca gccaataaat cgaggtcagc ctaaacccat acttcagaaa caatccactt    5400
ttccccagtc atccaaagac ataccagaca gaggggcagc aactgatgaa aagttacaga    5460
attttgctat tgaaaatact ccggtttgct tttctcataa ttcctctctg agttctctca    5520
gtgacattga ccaagaaaac aacaataaag aaaatgaacc tatcaaagag actgagcccc    5580
ctgactcaca gggagaacca agtaaacctc aagcatcagg ctatgctcct aaatcatttc    5640
atgttgaaga taccccagtt tgtttctcaa gaaacagttc tctcagttct cttagtattg    5700
actctgaaga tgacctgttg caggaatgta taagctccgc aatgccaaaa aagaaaaagc    5760
cttcaagact caagggtgat aatgaaaaac atagtcccag aaatatgggt ggcatattag    5820
gtgaagatct gacacttgat ttgaaagata tacagagacc agattcagaa catggtctat    5880
cccctgattc agaaaatttt gattggaaag ctattcagga aggtgcaaat tccatagtaa    5940
gtagtttaca tcaagctgct gctgctgcat gtttatctag acaagcttcg tctgattcag    6000
attccatcct ttccctgaaa tcaggaatct ctctgggatc accatttcat cttacacctg    6060
atcaagaaga aaaacccttt acaagtaata aaggcccacg aattctaaaa ccaggggaga    6120
aaagtacatt ggaaactaaa aagatagaat ctgaaagtaa aggaatcaaa ggaggaaaaa    6180
aagtttataa aagtttgatt actggaaaag ttcgatctaa ttcagaaatt tcaggccaaa    6240
tgaaacagcc ccttcaagca aacatgcctt caatctctcg aggcaggaca atgattcata    6300
ttccaggagt tcgaaatagc tcctcaagta caagtcctgt ttctaaaaaa ggcccacccc    6360
ttaagactcc agcctccaaa agccctagtg aaggtcaaac agccaccact tctcctagag    6420
gagccaagcc atctgtgaaa tcagaattaa gccctgttgc caggcagaca tcccaaatag    6480
gtgggtcaag taaagcacct tctagatcag gatctagaga ttcgacccct tcaagacctg    6540
cccagcaacc attaagtaga cctatacagt ctcctggccg aaactcaatt tcccctggta    6600
gaaatggaat aagtcctcct aacaaattat ctcaacttcc aaggacatca tcccctagta    6660
ctgcttcaac taagtcctca ggttctggaa aaatgtcata tacatctcca ggtagacaga    6720
tgagccaaca gaaccttacc aaacaaacag gtttatccaa gaatgccagt agtattccaa    6780
gaagtgagtc tgcctccaaa ggactaaatc agatgaataa tggtaatgga gccaataaaa    6840
aggtagaact ttctagaatg tcttcaacta aatcaagtgg aagtgaatct gatagatcag    6900
aaagacctgt attagtacgc cagtcaactt tcatcaaaga agctccaagc ccaaccttaa    6960
gaagaaaatt ggaggaatct gcttcatttg aatctctttc tccatcatct agaccagctt    7020
ctcccactag gtcccaggca caaactccag ttttaagtcc ttcccttcct gatatgtctc    7080
tatccacaca ttcgtctgtt caggctggtg gatggcgaaa actcccacct aatctcagtc    7140
ccactataga gtataatgat ggaagaccag caaagcgcca tgatattgca cggtctcatt    7200
ctgaaagtcc ttctagactt ccaatcaata ggtcaggaac ctggaaacgt gagcacagca    7260
aacattcatc atcccttcct cgagtaagca cttggagaag aactggaagt tcatcttcaa    7320
ttctttctgc ttcatcagaa tccagtgaaa aagcaaaaag tgaggatgaa aaacatgtga    7380
actctatttc aggaaccaaa caaagtaaag aaaaccaagt atccgcaaaa ggaacatgga    7440
gaaaaataaa agaaaatgaa ttttctccca caaatagtac ttctcagacc gtttcctcag    7500
gtgctacaaa tggtgctgaa tcaaagactc taatttatca aatggcacct gctgtttcta    7560
aaacagagga tgtttgggtg agaattgagg actgtcccat taacaatcct agatctggaa    7620
gatctcccac aggtaatact cccccggtga ttgacagtgt ttcagaaaag gcaaatccaa    7680
acattaaaga ttcaaaagat aatcaggcaa aacaaaatgt gggtaatggc agtgttccca    7740
tgcgtaccgt gggtttggaa aatcgcctga actcctttat tcaggtggat gcccctgacc    7800
aaaaaggaac tgagataaaa ccaggacaaa ataatcctgt ccctgtatca gagactaatg    7860
aaagttctat agtggaacgt accccattca gttctagcag ctcaagcaaa cacagttcac    7920
ctagtgggac tgttgctgcc agagtgactc cttttaatta caacccaagc cctaggaaaa    7980
gcagcgcaga tagcacttca gctcggccat ctcagatccc aactccagtg aataacaaca    8040
caaagaagcg agattccaaa actgacagca cagaatccag tggaacccaa agtcctaagc    8100
gccattctgg gtcttacctt gtgacatctg tttaaaagag aggaagaatg aaactaagaa    8160
aattctatgt taattacaac tgctatatag acattttgtt tcaaatgaaa ctttaaaaga    8220
ctgaaaaatt ttgtaaatag gtttgattct tgttagaggg tttttgttct ggaagccata    8280
tttgatagta tactttgtct tcactggtct tattttggga ggcactcttg atggttagga    8340
aaaaaatagt aaagccaagt atgtttgtac agtatgtttt acatgtattt aaagtagcat    8400
cccatcccaa cttcctttaa ttattgcttg tcttaaaata atgaacacta cagatagaaa    8460
atatgatata ttgctgttat caatcatttc tagattataa actgactaaa cttacatcag    8520
ggaaaaattg gtatttatgc aaaaaaaaat gtttttgtcc ttgtgagtcc atctaacatc    8580
ataattaatc atgtggctgt gaaattcaca gtaatatggt tcccgatgaa caagtttacc    8640
cagcctgctt tgctttactg catgaatgaa actgatggtt caatttcaga agtaatgatt    8700
aacagttatg tggtcacatg atgtgcatag agatagctac agtgtaataa tttacactat    8760
tttgtgctcc aaacaaaaca aaaatctgtg taactgtaaa acattgaatg aaactatttt    8820
acctgaacta gattttatct gaaagtaggt agaatttttg ctatgctgta atttgttgta    8880
tattctggta tttgaggtga gatggctgct cttttattaa tgagacatga attgtgtctc    8940
aacagaaact aaatgaacat ttcagaataa attattgctg tatgtaaact gttactgaaa    9000
ttggtatttg tttgaagggt cttgtttcac atttgtatta ataattgttt aaaatgcctc    9060
ttttaaaagc ttatataaat ttttttcttc agcttctatg cattaagagt aaaattcctc    9120
ttactgtaat aaaaacaatt gaagaagact gttgccactt aaccattcca tgcgttggca    9180
cttatctatt cctgaaattt cttttatgtg attagctcat cttgattttt aatatttttc    9240
cacttaaact tttttttctt actccactgg agctcagtaa aagtaaattc atgtaatagc    9300
aatgcaagca gcctagcaca gactaagcat tgagcataat aggcccacat aatttcctct    9360
ttcttaatat tatagaattc tgtacttgaa attgattctt agacattgca gtctcttcga    9420
ggctttacag tgtaaactgt cttgcccctt catcttcttg ttgcaactgg gtctgacatg    9480
aacacttttt atcaccctgt atgttagggc aagatctcag cagtgaagta taatcagcac    9540
tttgccatgc tcagaaaatt caaatcacat ggaactttag aggtagattt aatacgatta    9600
agatattcag aagtatattt tagaatccct gcctgttaag gaaactttat ttgtggtagg    9660
tacagttctg gggtacatgt taagtgtccc cttatacagt ggagggaagt cttccttcct    9720
gaaggaaaat aaactgacac ttattaacta agataattta cttaatatat cttccctgat    9780
ttgttttaaa agatcagagg gtgactgatg atacatgcat acatatttgt tgaataaatg    9840
aaaatttatt tttagtgata agattcatac actctgtatt tggggaggga aaaccttttt    9900
aagcatggtg gggcactcag ataggagtga atacacctac ctggtgcctt gaaaatcaca    9960
tcaagtagtt aattatctac cccttacctg tgtttataac ttccaggtaa tgagaatgat   10020
tttttttaaa gctaaaatgc cagtaaataa aagtgctatg acttgagcta agatatttga   10080
ctccaatgcc tgtactgtgt ctactgcacc actttgtaaa cacttcaatt tactatcttt   10140
gaaatgattg acctttaaat ttttgccaaa tgttatctga aattgtctat gaataccatc   10200
tacttctgtt gttttcccag gcttccataa acaatggaga tacatgca                10248

<210> 18
<211> 774
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Leu Asp Met Ala Met Glu Pro Asp Arg Lys Ala Ala Val Ser
 1               5                  10                  15
His Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile His Ser Gly Ala
            20                  25                  30
Thr Thr Thr Ala Pro Ser Leu Ser Gly Lys Gly Asn Pro Glu Glu Glu
        35                  40                  45
Asp Val Asp Thr Ser Gln Val Leu Tyr Glu Trp Glu Gln Gly Phe Ser
    50                  55                  60
Gln Ser Phe Thr Gln Glu Gln Val Ala Asp Ile Asp Gly Gln Tyr Ala
65                  70                  75                  80
Met Thr Arg Ala Gln Arg Val Arg Ala Ala Met Phe Pro Glu Thr Leu
                85                  90                  95
Asp Glu Gly Met Gln Ile Pro Ser Thr Gln Phe Asp Ala Ala His Pro
            100                 105                 110
Thr Asn Val Gln Arg Leu Ala Glu Pro Ser Gln Met Leu Lys His Ala
        115                 120                 125
Val Val Asn Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Thr Arg
    130                 135                 140
Ala Ile Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu Asp Gln Val Val
145                 150                 155                 160
Val Asn Lys Ala Ala Val Met Val His Gln Leu Ser Lys Lys Glu Ala
                165                 170                 175
Ser Arg His Ala Ile Met Arg Ser Pro Gln Met Val Ser Ala Ile Val
            180                 185                 190
Arg Thr Met Gln Asn Thr Asn Asp Val Glu Thr Ala Arg Cys Thr Ala
        195                 200                 205
Gly Thr Leu His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile
    210                 215                 220
Phe Lys Ser Gly Gly Ile Pro Ala Leu Val Lys Met Leu Gly Ser Pro
225                 230                 235                 240
Val Asp Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu His Asn Leu Leu
                245                 250                 255
Leu His Gln Glu Gly Ala Lys Met Ala Val Arg Leu Ala Gly Gly Leu
            260                 265                 270
Gln Lys Met Val Ala Leu Leu Asn Lys Thr Asn Val Lys Phe Leu Ala
        275                 280                 285
Ile Thr Thr Asp Cys Leu Gln Ile Leu Ala Tyr Gly Asn Gln Glu Ser
    290                 295                 300
Lys Leu Ile Ile Leu Ala Ser Gly Gly Pro Gln Ala Leu Val Asn Ile
305                 310                 315                 320
Met Arg Thr Tyr Thr Tyr Glu Lys Leu Leu Trp Thr Thr Ser Arg Val
                325                 330                 335
Leu Lys Val Leu Ser Val Cys Ser Ser Asn Lys Pro Ala Ile Val Glu
            340                 345                 350
Ala Gly Gly Met Gln Ala Leu Gly Leu His Leu Thr Asp Pro Ser Gln
        355                 360                 365
Arg Leu Val Gln Asn Cys Leu Trp Thr Leu Arg Asn Leu Ser Asp Ala
    370                 375                 380
Ala Thr Lys Gln Glu Gly Met Glu Gly Leu Leu Gly Thr Leu Val Gln
385                 390                 395                 400
Leu Leu Gly Ser Asp Asp Ile Asn Val Val Thr Cys Ala Ala Gly Ile
                405                 410                 415
Leu Ser Asn Leu Thr Cys Asn Asn Tyr Lys Asn Lys Met Met Val Cys
            420                 425                 430
Gln Val Gly Gly Ile Glu Ala Leu Val Arg Thr Val Leu Arg Ala Gly
        435                 440                 445
Asp Arg Glu Asp Ile Thr Glu Pro Ala Ile Cys Ala Leu Arg His Leu
    450                 455                 460
Thr Ser Arg His Gln Glu Ala Glu Met Ala Gln Asn Ala Val Arg Leu
465                 470                 475                 480
His Tyr Gly Leu Pro Val Val Val Lys Leu Leu His Pro Pro Ser His
                485                 490                 495
Trp Pro Leu Ile Lys Ala Thr Val Gly Leu Ile Arg Asn Leu Ala Leu
            500                 505                 510
Cys Pro Ala Asn His Ala Pro Leu Arg Glu Gln Gly Ala Ile Pro Arg
        515                 520                 525
Leu Val Gln Leu Leu Val Arg Ala His Gln Asp Thr Gln Arg Arg Thr
    530                 535                 540
Ser Met Gly Gly Thr Gln Gln Gln Phe Val Glu Gly Val Arg Met Glu
545                 550                 555                 560
Glu Ile Val Glu Gly Cys Thr Gly Ala Leu His Ile Leu Ala Arg Asp
                565                 570                 575
Val His Asn Arg Ile Val Ile Arg Gly Leu Asn Thr Ile Pro Leu Phe
            580                 585                 590
Val Gln Leu Leu Tyr Ser Pro Ile Glu Asn Ile Gln Arg Val Ala Ala
        595                 600                 605
Gly Val Leu Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Glu Ala Ile
    610                 615                 620
Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu His Ser Arg
625                 630                 635                 640
Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe Arg Met Ser
                645                 650                 655
Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr
            660                 665                 670
Ser Ser Leu Phe Arg Thr Glu Pro Met Ala Trp Asn Glu Thr Ala Asp
        675                 680                 685
Leu Gly Leu Asp Ile Gly Ala Gln Gly Glu Pro Leu Gly Tyr Arg Gln
    690                 695                 700
Asp Asp Pro Ser Tyr Arg Ser Phe His Ser Gly Gly Tyr Gly Gln Asp
705                 710                 715                 720
Ala Leu Gly Met Asp Pro Met Met Glu His Glu Met Gly Gly His His
                725                 730                 735
Pro Gly Ala Asp Tyr Pro Val Asp Gly Leu Pro Asp Leu Gly His Ala
            740                 745                 750
Gln Asp Leu Met Asp Gly Leu Pro Pro Gly Asp Ser Asn Gln Leu Ala
        755                 760                 765
Trp Phe Asp Thr Asp Leu
    770

<210> 19
<211> 3488
<212> DNA
<213> Homo sapiens

<400> 19
aagcctctcg gtctgtggca gcagcgttgg cccggccccg ggagcggaga gcgaggggag      60
gcggagacgg aggaaggtct gaggagcagc ttcagtcccc gccgagccgc caccgcaggt     120
cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta tttgaagtat     180
accatacaac tgttttgaaa atccagcgtg gacaatggct actcaaggct accttttgct     240
ccattttctg ctcactcctc ctaatggctt ggtgaaatag caaacaagcc accagcagga     300
atctagtctg gatgactgct tctggagcct ggatgcagta ccattcttcc actgattcac     360
tgatttgatg gagttggaca tggccatgga accagacaga aaagcggctg ttagtcactg     420
gcagcaacag tcttacctgg actctggaat ccattctggt gccactacca cagctccttc     480
tctgagtggt aaaggcaatc ctgaggaaga ggatgtggat acctcccaag tcctgtatga     540
gtgggaacag ggattttctc agtccttcac tcaagaacaa gtagctgata ttgatggaca     600
gtatgcaatg actcgagctc agagggtacg agctgctatg ttccctgaga cattagatga     660
gggcatgcag atcccatcta cacagtttga tgctgctcat cccactaatg tccagcgttt     720
ggctgaacca tcacagatgc tgaaacatgc agttgtaaac ttgattaact atcaagatga     780
tgcagaactt gccacacgtg caatccctga actgacaaaa ctgctaaatg acgaggacca     840
ggtggtggtt aataaggctg cagttatggt ccatcagctt tctaaaaagg aagcttccag     900
acacgctatc atgcgttctc ctcagatggt gtctgctatt gtacgtacca tgcagaatac     960
aaatgatgta gaaacagctc gttgtaccgc tgggaccttg cataaccttt cccatcatcg    1020
tgagggctta ctggccatct ttaagtctgg aggcattcct gccctggtga aaatgcttgg    1080
ttcaccagtg gattctgtgt tgttttatgc cattacaact ctccacaacc ttttattaca    1140
tcaagaagga gctaaaatgg cagtgcgttt agctggtggg ctgcagaaaa tggttgcctt    1200
gctcaacaaa acaaatgtta aattcttggc tattacgaca gactgccttc aaattttagc    1260
ttatggcaac caagaaagca agctcatcat actggctagt ggtggacccc aagctttagt    1320
aaatataatg aggacctata cttacgaaaa actactgtgg accacaagca gagtgctgaa    1380
ggtgctatct gtctgctcta gtaataagcc ggctattgta gaagctggtg gaatgcaagc    1440
tttaggactt cacctgacag atccaagtca acgtcttgtt cagaactgtc tttggactct    1500
caggaatctt tcagatgctg caactaaaca ggaagggatg gaaggtctcc ttgggactct    1560
tgttcagctt ctgggttcag atgatataaa tgtggtcacc tgtgcagctg gaattctttc    1620
taacctcact tgcaataatt ataagaacaa gatgatggtc tgccaagtgg gtggtataga    1680
ggctcttgtg cgtactgtcc ttcgggctgg tgacagggaa gacatcactg agcctgccat    1740
ctgtgctctt cgtcatctga ccagccgaca ccaagaagca gagatggccc agaatgcagt    1800
tcgccttcac tatggactac cagttgtggt taagctctta cacccaccat cccactggcc    1860
tctgataaag gctactgttg gattgattcg aaatcttgcc ctttgtcccg caaatcatgc    1920
acctttgcgt gagcagggtg ccattccacg actagttcag ttgcttgttc gtgcacatca    1980
ggatacccag cgccgtacgt ccatgggtgg gacacagcag caatttgtgg agggggtccg    2040
catggaagaa atagttgaag gttgtaccgg agcccttcac atcctagctc gggatgttca    2100
caaccgaatt gttatcagag gactaaatac cattccattg tttgtgcagc tgctttattc    2160
tcccattgaa aacatccaaa gagtagctgc aggggtcctc tgtgaacttg ctcaggacaa    2220
ggaagctgca gaagctattg aagctgaggg agccacagct cctctgacag agttacttca    2280
ctctaggaat gaaggtgtgg cgacatatgc agctgctgtt ttgttccgaa tgtctgagga    2340
caagccacaa gattacaaga aacggctttc agttgagctg accagctctc tcttcagaac    2400
agagccaatg gcttggaatg agactgctga tcttggactt gatattggtg cccagggaga    2460
accccttgga tatcgccagg atgatcctag ctatcgttct tttcactctg gtggatatgg    2520
ccaggatgcc ttgggtatgg accccatgat ggaacatgag atgggtggcc accaccctgg    2580
tgctgactat ccagttgatg ggctgccaga tctggggcat gcccaggacc tcatggatgg    2640
gctgcctcca ggtgacagca atcagctggc ctggtttgat actgacctgt aaatcatcct    2700
ttagctgtat tgtctgaact tgcattgtga ttggcctgta gagttgctga gagggctcga    2760
ggggtgggct ggtatctcag aaagtgcctg acacactaac caagctgagt ttcctatggg    2820
aacaattgaa gtaaactttt tgttctggtc ctttttggtc gaggagtaac aatacaaatg    2880
gattttggga gtgactcaag aagtgaagaa tgcacaagaa tggatcacaa gatggaattt    2940
atcaaaccct agccttgctt gttaaatttt tttttttttt tttttaagaa tatctgtaat    3000
ggtactgact ttgcttgctt tgaagtagct cttttttttt tttttttttt ttttttgcag    3060
taactgtttt ttaagtctct cgtagtgtta agttatagtg aatactgcta cagcaatttc    3120
taatttttaa gaattgagta atggtgtaga acactaattc ataatcactc taattaattg    3180
taatctgaat aaagtgtaac aattgtgtag cctttttgta taaaatagac aaatagaaaa    3240
tggtccaatt agtttccttt ttaatatgct taaaataagc aggtggatct atttcatgtt    3300
tttgatcaaa aactatttgg gatatgtatg ggtagggtaa atcagtaaga ggtgttattt    3360
ggaaccttgt tttggacagt ttaccagttg ccttttatcc caaagttgtt gtaacctgct    3420
gtgatacgat gcttcaagag aaaatgcggt tataaaaaat ggttcagaat taaactttta    3480
attcattc                                                             3488
