                         SEQUENCE LISTING

<110>  NATIONAL RESEARCH COUNCIL OF CANADA
 
<120>  ANTI-EGFRVIII ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS THEREOF

<130>  16600-001-PCT

<150>  US 62/824,386
<151>  2019-03-27

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  2
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  2
ctggaggaaa agaaagtttg ccaaggcacg agtaacaagc tcacgcagtt gggcactttt       60

gaagatcatt ttctcagcct ccagaggatg ttcaataact gtgaggtggt ccttgggaat      120

ttggaaatta cctatgtgca gaggaattat gatctttcct tcttaaagac catccaggag      180

gtggctggtt atgtcctcat tgccctcaac acagtggagc gaattccttt ggaaaacctg      240

cagatcatca gaggaaatat gtactacgaa aattcctatg ccttagcagt cttatctaac      300

tatgatgcaa ataaaaccgg actgaaggag ctgcccatga gaaatttaca ggaaatcctg      360

catggcgccg tgcggttcag caacaaccct gccctgtgca acgtggagag catccagtgg      420

cgggacatag tcagcagtga ctttctcagc aacatgtcga tggacttcca gaaccacctg      480

ggcagctgcc aaaagtgtga tccaagctgt cccaatggga gctgctgggg tgcaggagag      540

gagaactgcc agaaactgac caaaatcatc tgtgcccagc agtgctccgg gcgctgccgt      600

ggcaagtccc ccagtgactg ctgccacaac cagtgtgctg caggctgcac aggcccccgg      660

gagagcgact gcctggtctg ccgcaaattc cgagacgaag ccacgtgcaa ggacacctgc      720

cccccactca tgctctacaa ccccaccacg taccagatgg atgtgaaccc cgagggcaaa      780

tacagctttg gtgccacctg cgtgaagaag tgtccccgta attatgtggt gacagatcac      840

ggctcgtgcg tccgagcctg tggggccgac agctatgaga tggaggaaga cggcgtccgc      900

aagtgtaaga agtgcgaagg gccttgccgc aaagtgtgta acggaatagg tattggtgaa      960

tttaaagact cactctccat aaatgctacg aatattaaac acttcaaaaa ctgcacctcc     1020

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacatact     1080

cctcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     1140

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     1200

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     1260

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     1320

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     1380

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     1440

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     1500

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     1560

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     1620

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     1680

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     1740

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     1800

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     1860

tccatcgcc                                                             1869


<210>  3
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      


Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          


Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              


Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  


Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  


Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         


Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             


Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 


Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 


Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     


Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         


Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             


His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 


Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 


Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     


Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         


Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
    450                 455                 460                 


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
465                 470                 475                 480 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
                485                 490                 495     


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
            500                 505                 510         


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
        515                 520                 525             


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
    530                 535                 540                 


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
545                 550                 555                 560 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
                565                 570                 575     


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
            580                 585                 590         


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
        595                 600                 605             


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
    610                 615                 620     


<210>  4
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EGFRvIII ectodomain cDNA sequence (nucleotides 1-996)

<400>  4
ctggaagaga agaaaggcaa ctacgtcgtg accgaccacg gcagctgtgt gcgggcttgt       60

ggcgccgata gctacgagat ggaagaggac ggcgtgcgga agtgcaagaa gtgcgagggc      120

ccctgccgga aagtgtgcaa cggcatcggc atcggagagt tcaaggacag cctgagcatc      180

aacgccacca acatcaagca cttcaagaac tgcaccagca tcagcggcga cctgcacatc      240

ctgcccgtgg cctttagagg cgacagcttc acccacaccc ccccactgga cccccaggaa      300

ctggacatcc tgaaaaccgt gaaagagatc accggctttc tgctgattca ggcctggccc      360

gagaaccgga cagacctgca cgccttcgag aacctggaaa tcatccgggg caggaccaag      420

cagcacggcc agttttctct ggccgtggtg tccctgaaca tcaccagcct gggcctgcgg      480

agcctgaaag aaatcagcga cggcgacgtg atcatctccg gcaacaagaa cctgtgctac      540

gccaacacca tcaactggaa gaagctgttc ggcacctccg gccagaaaac aaagatcatc      600

agcaaccggg gcgagaacag ctgcaaggcc acaggacaag tgtgccacgc cctgtgtagc      660

cctgagggct gttggggacc cgagcccaga gattgcgtgt cctgcagaaa cgtgtcccgg      720

ggcagagaat gcgtggacaa gtgcaacctg ctggaaggcg agccccgcga gttcgtggaa      780

aacagcgagt gcatccagtg ccaccccgag tgtctgcccc aggccatgaa cattacctgc      840

accggcagag gccccgacaa ctgtatccag tgcgcccact acatcgacgg cccccactgc      900

gtgaaaacct gtcctgctgg cgtgatggga gagaacaaca ccctcgtgtg gaagtacgcc      960

gacgccggcc atgtgtgcca cctgtgtcac cccaat                                996


<210>  5
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human EGFRvIII ectodomain amino acid sequence (amino acids 1-332)

<400>  5

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    50                  55                  60                  


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
65                  70                  75                  80  


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
                85                  90                  95      


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
            100                 105                 110         


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
        115                 120                 125             


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
    130                 135                 140                 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
145                 150                 155                 160 


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
                165                 170                 175     


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
            180                 185                 190         


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
        195                 200                 205             


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
    210                 215                 220                 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
225                 230                 235                 240 


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
                245                 250                 255     


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
            260                 265                 270         


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
        275                 280                 285             


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
    290                 295                 300                 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
305                 310                 315                 320 


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn 
                325                 330         


<210>  6
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human EGFRvIII amino acid residues 15 to 37

<400>  6

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 light chain variable region

<400>  7

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Ala Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Ala 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRL1

<400>  8

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRL2

<400>  9

Leu Ala Ser Lys Leu Asp Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRL3

<400>  10

Trp Gln Ala Thr His Phe Pro Trp Thr 
1               5                   


<210>  11
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5G6 - Light chain variable region cDNA

<400>  11
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggcctggcca gtctccaaag cgcctaatct atctggcgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaagctac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 heavy chain variable region

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Tyr Asp Tyr Asp Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRH1

<400>  13

Ser Tyr Trp Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRH2

<400>  14

Ala Ile Tyr Pro Gly Asn Ser Asp Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 CDRH3

<400>  15

Tyr Asp Tyr Asp Pro Asp Tyr 
1               5           


<210>  16
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5G6 - Heavy chain variable region cDNA

<400>  16
gaggtccaac tgcagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacctttacc agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggcgct atttatcctg gaaatagtga tattagctac      180

aatcagaagt tcaagggcaa ggccaaactg actgcagtca catccgccac cactgcctac      240

atggagctca gcagcctaac aaatgaggac tctgcggtct attactgtac cctctatgat      300

tacgaccctg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 light chain variable region

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRL1

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRL2

<400>  19

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRL3

<400>  20

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  21
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1A8 light chain variable region cDNA

<400>  21
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact       60

atgaactgca agtccagtca gagcctttta aatagtagca atcaaaagaa ctatttggcc      120

tggttccagc agaaaccagg acagtctcct aaacttctgg tatactttgc ttccactagg      180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact      300

cctctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  22
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 heavy chain variable region

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Leu Leu Leu Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRH1

<400>  23

Asp Tyr Tyr Met His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRH2

<400>  24

Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDRH3

<400>  25

Gly Trp Leu Leu Leu 
1               5   


<210>  26
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1A8 heavy chain variable region cDNA

<400>  26
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaagttg       60

tcctgcaaag cttctggctt caacattaaa gactactata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtaa tactatatat      180

gacccgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctggc atctgaggac actgccgtct attactgtgc tagaggatgg      300

ttactacttt ggggccaagg caccactctc acagtctcct ca                         342


<210>  27
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 light chain variable region

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Glu 
            100                 105             


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRL1

<400>  28

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRL2

<400>  29

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRL3

<400>  30

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  31
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3 light chain variable region cDNA

<400>  31
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggt      300

gctgggacca agctggaact ggaa                                             324


<210>  32
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 heavy chain variable region

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asp Tyr Asp Leu Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRH1

<400>  33

Asp Tyr Asn Met Asp 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRH2

<400>  34

Thr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 CDRH3

<400>  35

Gly Tyr Asp Tyr Asp Leu Trp Phe Ala Tyr 
1               5                   10  


<210>  36
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3 heavy chain variable region cDNA

<400>  36
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctgggtcttc agtgaagata       60

tcctgcaaag cttctggata cacattcact gactacaaca tggactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggtact attaatccta acaatggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccaa cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaggctat      300

gattacgact tgtggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 light chain variable region

<400>  37

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Leu Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRL1

<400>  38

His Ala Ser Gln Gly Ile Asn Ser Asn Ile Gly 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRL2

<400>  39

His Gly Thr Asn Leu Glu Asp 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRL3

<400>  40

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  41
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4E11 light chain variable region cDNA

<400>  41
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc       60

atcacttgcc atgcaagtca gggcattaac agtaatatag ggtggttgct gcagaaacca      120

gggaaatcat ttaagggcct gatctatcat ggaaccaact tggaagatgg agttccatca      180

aggttcagtg gcagtggatc tggaacagat tattctctca ccatcagcag cctggaatct      240

gaggattttg ctgactatta ctgtgtacag tatgctcagt ttccgtacac gttcggaggg      300

gggaccaaac tggaaataaa a                                                321


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 heavy chain variable region

<400>  42

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Tyr Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRH1

<400>  43

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRH2

<400>  44

Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 CDRH3

<400>  45

Leu Gly Arg Gly Phe Ala Tyr 
1               5           


<210>  46
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4E11 heavy chain variable region cDNA

<400>  46
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataggct acaatggtag aactagttac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attatgtgac tactgaggac acagccacat tttactgtgc aagactgggc      300

cgagggtttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  47
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 light chain variable region

<400>  47

Glu Ile Val Leu Thr Gln Ser Pro Val Phe Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRL1

<400>  48

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRL2

<400>  49

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRL3

<400>  50

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  51
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D8 light chain variable region cDNA

<400>  51
gaaattgtgc tcacccagtc tccagtattc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggt      300

gctgggacca agctggagct gaaa                                             324


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 heavy chain variable region

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Asn Pro Asn Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asp Tyr Asp Leu Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRH1

<400>  53

Asp Tyr Asn Ile Asp 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRH2

<400>  54

Thr Ile Asn Pro Asn Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D8 CDRH3

<400>  55

Gly Tyr Asp Tyr Asp Leu Trp Phe Ala Tyr 
1               5                   10  


<210>  56
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D8 heavy chain variable region cDNA

<400>  56
gaggtccagc tgcaacagtc tggacctgac ctggtgaagc ctgggtcttc agtgaagatt       60

tcctgcaaag cttctggata cacattcact gactacaaca ttgactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggaact attaatccta actatggtgg tacttcctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaggctat      300

gattacgact tgtggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 light chain variable region

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Thr Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ile Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRL1

<400>  58

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRL2

<400>  59

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRL3

<400>  60

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  61
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9C9 light chain variable region cDNA

<400>  61
gaaattgtgc tcacccagtc tccaacactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat gacacatcca acctggcttc tggagtccct      180

attcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcgtggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggc      300

tcggggacaa agttggaaat aaaa                                             324


<210>  62
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 heavy chain variable region

<400>  62

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRH1

<400>  63

Ser Tyr Trp Met His 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRH2

<400>  64

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9C9 CDRH3

<400>  65

Phe Asp Phe Ala Tyr 
1               5   


<210>  66
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9C9 heavy chain variable region cDNA

<400>  66
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaaacagagg      120

cctggacaag accttgagtg gatcggagag attgatcctt ctgatagtta tactaactac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

attcagctca gcagcctgac atctgaggac tctgcgctct attactgtgc aagattcgat      300

tttgcttact ggggccaagg gactctggtc actgtctctg ca                         342


<210>  67
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 light chain 1 (L1) variable region (dominant)

<400>  67

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L1 CDRL1

<400>  68

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L1 CDRL2

<400>  69

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L1 CDRL3

<400>  70

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  71
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11B1 light chain 1 (L1) variable region cDNA (dominant)

<400>  71
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta tatagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  72
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 light chain 2 (L2) variable region

<400>  72

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Cys Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Met 
                85                  90                  95      


His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L2 CDRL1

<400>  73

Arg Ala Ser Ser Ser Val Asn Tyr Met Tyr 
1               5                   10  


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L2 CDRL2

<400>  74

Tyr Thr Ser Asn Leu Ala Pro 
1               5           


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 L2 CDRL3

<400>  75

Gln Gln Phe Thr Ser Ser Pro Ser Met His Thr 
1               5                   10      


<210>  76
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11B1 light chain 2 (L2) variable region cDNA

<400>  76
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctctagggga gaaggtcacc       60

atgagctgca gggccagctc aagtgtaaat tacatgtact ggtgccagca gaagtcagat      120

gcctccccca aactatggat ttattacaca tccaacctgg ctcctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gaactcttat tctctcacaa tcagcagcat ggagggtgaa      240

gatgttgcca cttattactg ccagcagttt actagttccc catccatgca cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  77
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 heavy chain variable region

<400>  77

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Lys Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Tyr Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 CDRH1

<400>  78

Thr Ala Gly Met Gln 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 CDRH2

<400>  79

Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11B1 CDRH3

<400>  80

Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  81
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11B1 heavy chain variable region cDNA

<400>  81
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca actgctggaa tgcagtgggt aaaaaagatg      120

ccaggaaagg gttttaagtg gattggctgg ataaacaccc actctggaga tccaaaatat      180

gcagaagact tcaagggacg gtttgccttc tctttggaaa cctacgccag tactgcatat      240

ttgcagataa gcaacctcaa aaacgaggac actgcttcgt atttctgtgc gaggacccac      300

atctatgatg gttataacta tgctatggac tactggggtc aagggacctc agtcaccgtc      360

tcctca                                                                 366


<210>  82
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 light chain 1 (L1) variable region (dominant)

<400>  82

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L1 CDRL1

<400>  83

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L1 CDRL2

<400>  84

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L1 CDRL3

<400>  85

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  86
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11C8 light chain 1 (L1) variable region cDNA (dominant)

<400>  86
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta tatagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  87
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 light chain 2 (L2) variable region

<400>  87

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Cys Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Met 
                85                  90                  95      


His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L2 CDRL1

<400>  88

Arg Ala Ser Ser Ser Val Asn Tyr Met Tyr 
1               5                   10  


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L2 CDRL2

<400>  89

Tyr Thr Ser Asn Leu Ala Pro 
1               5           


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 L2 CDRL3

<400>  90

Gln Gln Phe Thr Ser Ser Pro Ser Met His Thr 
1               5                   10      


<210>  91
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11C8 light chain 2 (L2) variable region cDNA

<400>  91
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctctagggga gaaggtcacc       60

atgagctgca gggccagctc aagtgtaaat tacatgtact ggtgccagca gaagtcagat      120

gcctccccca aactatggat ttattacaca tccaacctgg ctcctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gaactcttat tctctcacaa tcagcagcat ggagggtgaa      240

gatgttgcca cttattactg ccagcagttt actagttccc catccatgca cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  92
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 heavy chain variable region

<400>  92

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Tyr Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 CDRH1

<400>  93

Thr Ala Gly Met Gln 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 CDRH2

<400>  94

Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C8 CDRH3

<400>  95

Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  96
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11C8 heavy chain variable region cDNA

<400>  96
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca actgctggaa tgcagtgggt acaaaagatg      120

ccaggaaagg gttttaagtg gattggctgg ataaacaccc actctggaga tccaaaatat      180

gcagaagact tcaagggacg gtttgccttc tctttggaaa cctacgccag tactgcatat      240

ttgcagataa gcaacctcaa aaacgaggac actgcttcgt atttctgtgc gaggacccac      300

atctatgatg gttacaacta tgctatggac tactggggtc aagggacctc agtcaccgtc      360

tcctca                                                                 366


<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 light chain variable region

<400>  97

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRL1

<400>  98

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRL2

<400>  99

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRL3

<400>  100

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  101
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11H3 light chain variable region cDNA

<400>  101
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta tatagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  102
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 heavy chain variable region

<400>  102

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Tyr Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRH1

<400>  103

Thr Ala Gly Met Gln 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRH2

<400>  104

Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11H3 CDRH3

<400>  105

Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  106
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11H3 heavy chain variable region cDNA

<400>  106
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca actgctggaa tgcagtgggt acaaaagatg      120

ccaggaaagg gttttaagtg gattggctgg ataaacaccc actctggaga tccaaaatat      180

gcagaagact tcaagggacg gtttgccttc tctttggaaa cctacgccag cactgcatat      240

ttgcagataa gcaacctcaa aaacgaggac actgctacgt atttctgtgc gaggacccat      300

atctatgatg gttataatta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  107
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 Heavy chain human IgG1

<400>  107

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Tyr Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  108
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E11 Light chain human Kappa

<400>  108

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Leu Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  109
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 Heavy chain human IgG1

<400>  109

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Tyr Asp Tyr Asp Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  110
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G6 Light chain human Kappa

<400>  110

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Ala Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Ala 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  111
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13.1.2 Heavy chain human IgG1

<400>  111

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Trp Gln Gln Leu Ala Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  112
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13.1.2 Light chain human Kappa

<400>  112

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu His Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  113
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal light chain signal sequence

<400>  113

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  114
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal heavy chain signal sequence

<400>  114

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  115
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VLs of 4B3 and 5D8


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a conservative amino acid substitution to alanine (A) or 
       valine (V) or is alanine or valine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a conservative amino acid substitution to leucine (L) or 
       phenylalanine (F) or is leucine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is a conservative amino acid substitution to lysine (K) or 
       glutamic acid (E) or is lysine or glutamic acid

<400>  115

Glu Ile Val Leu Thr Gln Ser Pro Xaa Xaa Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Xaa 
            100                 105             


<210>  116
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VHs of 4B3 and 5D8


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a conservative amino acid substitution to glutamic acid (E) 
       or aspartic acid (D) or is glutamic acid or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is a conservative amino acid substitution to methionine (M) or 
       isoleucine (I) or is methionine or isoleucine

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is a conservative amino acid substitution to asparagine (N) or 
       tyrosine (Y) or is asparagine or tyrosine

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is a conservative amino acid substitution to asparagine (N) or 
       serine (S) or is asparagine or serine

<400>  116

Glu Val Gln Leu Gln Gln Ser Gly Pro Xaa Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Xaa Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Asn Pro Asn Xaa Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Xaa Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asp Tyr Asp Leu Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  117
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of VHs of 11B1, 11C8 and 11H3


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is a conservative amino acid substitution to lysine (K) or 
       glutamine (Q) or is lysine or glutamine

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is conservative amino acid substitution to serine (S) or 
       threonine (T) or is serine or threonine

<400>  117

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Xaa Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Asp Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Tyr Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Xaa Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr His Ile Tyr Asp Gly Tyr Asn Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val 
        115                 120 


<210>  118
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VLs of 4B3, 5D8 and 9C9


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a conservative amino acid substitution to alanine (A), 
       threonine (T) or valine (V) or is alanine, threonine or valine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a conservative amino acid substitution to leucine (L) or 
       phenylalanine (F) or is leucine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is a conservative amino acid substitution to glycine (G) or 
       aspartic acid (D) or is glycine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is a conservative amino acid substitution to isoleucine (I) or 
       valine (V) or is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is a conservative amino acid substitution to methionine (M) or 
       valine (V) or is methionine or valine

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is a conservative amino acid substitution to alanine (A) or 
       serine (S) or is alanine or serine

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X is a conservative amino acid substitution to isoleucine (I) or 
       leucine (L) or is isoleucine or leucine

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is a conservative amino acid substitution to lysine (K) or 
       glutamic acid (E) or is lysine or glutamic acid

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Xaa Xaa Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Xaa Thr Ser Asn Leu Ala Ser Gly Val Pro Xaa Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Xaa Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
            100                 105             


<210>  119
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 76 of EGFRvIII

<400>  119

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    50                  55                  60                  


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
65                  70                  75      


<210>  120
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 62 of EGFRvIII

<400>  120

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala 
    50                  55                  60          


<210>  121
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 49 of EGFRvIII

<400>  121

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile 
    


<210>  122
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 45 of EGFRvIII

<400>  122

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
        35                  40                  45  


<210>  123
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 37 of EGFRvIII

<400>  123

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys 
        35          


<210>  124
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 33 of EGFRvIII

<400>  124

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg 
    


<210>  125
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1 to 18 of EGFRvIII

<400>  125

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg 
        


<210>  126
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 3 to 49 of EGFRvIII

<400>  126

Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
1               5                   10                  15      


Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
            20                  25                  30          


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile 
        35                  40                  45          


<210>  127
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 3 to 45 of EGFRvIII

<400>  127

Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
1               5                   10                  15      


Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
            20                  25                  30          


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
        35                  40              


<210>  128
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 3 to 37 of EGFRvIII

<400>  128

Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
1               5                   10                  15      


Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
            20                  25                  30          


Cys Lys Lys 
        35  


<210>  129
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 3 to 18 of EGFRvIII

<400>  129

Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
1               5                   10                  15      


<210>  130
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 6 to 49 of EGFRvIII

<400>  130

Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
1               5                   10                  15      


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
            20                  25                  30          


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile 
        35                  40                  


<210>  131
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 6 to 45 of EGFRvIII

<400>  131

Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
1               5                   10                  15      


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
            20                  25                  30          


Cys Glu Gly Pro Cys Arg Lys Val 
        35                  40  


<210>  132
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 6 to 37 of EGFRvIII

<400>  132

Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
1               5                   10                  15      


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
            20                  25                  30          


<210>  133
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 10 to 49 of EGFRvIII

<400>  133

Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr 
1               5                   10                  15      


Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro 
            20                  25                  30          


Cys Arg Lys Val Cys Asn Gly Ile 
        35                  40  


<210>  134
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 10 to 45 of EGFRvIII

<400>  134

Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr 
1               5                   10                  15      


Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro 
            20                  25                  30          


Cys Arg Lys Val 
        35      


<210>  135
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 10 to 37 of EGFRvIII

<400>  135

Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr 
1               5                   10                  15      


Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
            20                  25              


<210>  136
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 49 of EGFRvIII

<400>  136

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys 
            20                  25                  30          


Asn Gly Ile 
        35  


<210>  137
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 45 of EGFRvIII

<400>  137

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
            20                  25                  30      


<210>  138
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 19 to 76 of EGFRvIII

<400>  138

Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
1               5                   10                  15      


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly 
            20                  25                  30          


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
        35                  40                  45              


His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
    50                  55              


<210>  139
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 19 to 62 of EGFRvIII

<400>  139

Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
1               5                   10                  15      


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly 
            20                  25                  30          


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala 
        35                  40                  


<210>  140
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 19 to 49 of EGFRvIII

<400>  140

Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
1               5                   10                  15      


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile 
            20                  25                  30      


<210>  141
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 19 to 45 of EGFRvIII

<400>  141

Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
1               5                   10                  15      


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
            20                  25          


<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 19 to 37 of EGFRvIII

<400>  142

Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
1               5                   10                  15      


Cys Lys Lys 
            


<210>  143
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 28 to 45 of EGFRvIII

<400>  143

Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg 
1               5                   10                  15      


Lys Val 
        


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 28 to 37 of EGFRvIII

<400>  144

Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
1               5                   10  


<210>  145
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Ser15 to Ala 
       mutation

<400>  145

Ala Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  146
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Cys16 to Ala 
       mutation

<400>  146

Ser Ala Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  147
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Val17 to Ala 
       mutation

<400>  147

Ser Cys Ala Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  148
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Arg18 to Ala 
       mutation

<400>  148

Ser Cys Val Ala Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  149
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Cys20 to Ala 
       mutation

<400>  149

Ser Cys Val Arg Ala Ala Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  150
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Gly21 to Ala 
       mutation

<400>  150

Ser Cys Val Arg Ala Cys Ala Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  151
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Asp23 to Ala 
       mutation

<400>  151

Ser Cys Val Arg Ala Cys Gly Ala Ala Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  152
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Ser24 to Ala 
       mutation

<400>  152

Ser Cys Val Arg Ala Cys Gly Ala Asp Ala Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  153
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Tyr25 to Ala 
       mutation

<400>  153

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Ala Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  154
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Glu26 to Ala 
       mutation

<400>  154

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Ala Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  155
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Met27 to Ala 
       mutation

<400>  155

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Ala Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  156
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Glu28 to Ala 
       mutation

<400>  156

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Ala Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  157
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Glu29 to Ala 
       mutation

<400>  157

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Ala Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  158
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Asp30 to Ala 
       mutation

<400>  158

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Ala 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Lys 
            20              


<210>  159
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Gly31 to Ala 
       mutation

<400>  159

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Ala Val Arg Lys Cys Lys Lys 
            20              


<210>  160
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Val32 to Ala 
       mutation

<400>  160

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Ala Arg Lys Cys Lys Lys 
            20              


<210>  161
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Arg33 to Ala 
       mutation

<400>  161

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Ala Lys Cys Lys Lys 
            20              


<210>  162
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Lys34 to Ala 
       mutation

<400>  162

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Ala Cys Lys Lys 
            20              


<210>  163
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Cys35 to Ala 
       mutation

<400>  163

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Ala Lys Lys 
            20              


<210>  164
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Lys36 to Ala 
       mutation

<400>  164

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Ala Lys 
            20              


<210>  165
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 15 to 37 of EGFRvIII, with Lys37 to Ala 
       mutation

<400>  165

Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp 
1               5                   10                  15      


Gly Val Arg Lys Cys Lys Ala 
            20              


<210>  166
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-chain variable fragment composed of VH, linker, VL 
       sequence derived from 5G6 antibody

<400>  166

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Tyr Asp Tyr Asp Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
    130                 135                 140                 


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Ala Ser Lys Leu Asp 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Trp Gln Ala Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  167
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-chain variable fragment composed of VH, linker, VL 
       sequence derived from 4E11 antibody

<400>  167

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Tyr Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Val Asp Ile Leu Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Asn Ser Asn Ile Gly Trp Leu Leu Gln Lys Pro Gly Lys 
                165                 170                 175     


Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Glu Asp Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln 
    210                 215                 220                 


Tyr Ala Gln Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  168
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct composed of 5G6 scFV, a CD8 hinge, human CD28 
       transmembrane domain, human CD28-signaling domain, and human 
       CD3-zeta signaling domain

<400>  168

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
            20                  25                  30          


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Ile Ser Tyr Asn Gln 
65                  70                  75                  80  


Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr 
                85                  90                  95      


Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Tyr Cys Thr Leu Tyr Asp Tyr Asp Pro Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr 
145                 150                 155                 160 


Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
                165                 170                 175     


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu 
            180                 185                 190         


Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Ala Ser Lys 
        195                 200                 205             


Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
225                 230                 235                 240 


Tyr Tyr Cys Trp Gln Ala Thr His Phe Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Ser Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  169
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct composed of 4E11 scFV, a CD8 hinge, human CD28 
       transmembrane domain, human CD28-signaling domain, and human 
       CD3-zeta signaling domain

<400>  169

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Tyr Val Thr Thr Glu Asp Thr Ala Thr Phe 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Val Asp Ile Leu Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His 
                165                 170                 175     


Ala Ser Gln Gly Ile Asn Ser Asn Ile Gly Trp Leu Leu Gln Lys Pro 
            180                 185                 190         


Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Glu Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Val Gln Tyr Ala Gln Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Ala Ser Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  170
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   4E11 bi-specific T cell engager exemplary sequence

<400>  170

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gly Tyr Asn Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Tyr Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Leu Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Val Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met 
145                 150                 155                 160 


Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln 
                165                 170                 175     


Gly Ile Asn Ser Asn Ile Gly Trp Leu Leu Gln Lys Pro Gly Lys Ser 
            180                 185                 190         


Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr 
225                 230                 235                 240 


Ala Gln Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Lys 
            260                 265                 270         


Leu Gly Asp Leu Gly Gly Gly Gly Ser Arg Asp Asp Asp Ile Lys Leu 
        275                 280                 285             


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
    290                 295                 300                 


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
305                 310                 315                 320 


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
                325                 330                 335     


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
            340                 345                 350         


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
        355                 360                 365             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
    370                 375                 380                 


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
385                 390                 395                 400 


Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                405                 410                 415     


Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met 
            420                 425                 430         


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        435                 440                 445             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
    450                 455                 460                 


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                485                 490                 495     


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            500                 505                 510         


Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        515                 520                 525         


<210>  171
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  171

Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asp Val 
            


