                         SEQUENCE LISTING

<110>  PEKING UNIVERSITY
       EdiGene Inc.
 
<120>  METHOD FOR IDENTIFYING FUNCTIONAL ELEMENTS

<130>  FD00215PCT

<150>  PCT/CN2019/079729
<151>  2019-03-26

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  1
gaccggaaag tccgtttgca agaggcag                                          28


<210>  2
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  2
ctagccctct ccgccgctcc aggctc                                            26


<210>  3
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  3
ctgcctcttg caaacggact ttccggtc                                          28


<210>  4
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  4
gcaagaggca gatctgcttt tgagagtc                                          28


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  5
gactctcaaa agcagatctg cctcttgc                                          28


<210>  6
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  6
cggaaataca aggactgcat ccatggag                                          28


<210>  7
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  7
ctccatggat gcagtccttg tatttccg                                          28


<210>  8
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  8
ggacttctgc atccatgaat gcaaatatgt g                                      31


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  9
cacatatttg cattcatgga tgcagaagtc c                                      31


<210>  10
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  10
gaatgcaaat atgtggagct ccgggctcc                                         29


<210>  11
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  11
ggagcccgga gctccacata tttgcattc                                         29


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  12
atgtgaagga gcgggctccc tcctgc                                            26


<210>  13
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  13
gcaggaggga gcccgctcct tcacat                                            26


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  14
gctccctcct gctgccaccc gggttac                                           27


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  15
gtaacccggg tggcagcagg agggagc                                           27


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  16
ccctcctgca tccacccggg ttacc                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  17
ggtaacccgg gtggatgcag gaggg                                             25


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  18
ctgccacccg ggtcatggag agaggtgtc                                         29


<210>  19
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  19
gacacctctc tccatgaccc gggtggcag                                         29


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  20
ccgggttacc atggaaggtg tcatgggc                                          28


<210>  21
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  21
gcccatgaca ccttccatgg taacccgg                                          28


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  22
gcctcccagt ggaacgctta tatacctatg                                        30


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  23
cataggtata taagcgttcc actgggaggc                                        30


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  24
cctcccagtg gaaaatttat atacctatga cc                                     32


<210>  25
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating mutants for HBEGF

<400>  25
ggtcataggt atataaattt tccactggga gg                                     32


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplifying sgRNA oligos targeting 
       drug-associated proteins

<400>  26
ttgtggaaag gacgaaaccg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplifying sgRNA oligos targeting 
       drug-associated proteins

<400>  27
tgctgtctct agctctacgt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplifying sgRNA oligos targeting toxin 
       receptors

<400>  28
tcttcatatc gtatcgtgcg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplifying sgRNA oligos targeting toxin 
       receptors

<400>  29
tagtcgctag gctataacgt                                                   20


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  30
aacagcatcg gagcggaaa                                                    19


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  31
tgggctttat caccactcct c                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  32
aataaaggac ccgcgaggaa g                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  33
ttttcaggag tgtgctgtcc g                                                 21


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  34
tcccagctcc caggactc                                                     18


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  35
gggtgttctg agtgtgcagt                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  36
agagagccac tgtgtggatg c                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  37
ggaagtgtgc tcgccgtcag                                                   20


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  38
gggctcgtgc tgttctcac                                                    19


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  39
gcaccaggca tggaagcaat                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  40
cgaaagtgac tggtgcctcg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  41
ggtcccaatg gcagatccct                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  42
aggcgaacct ctcggcttt                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  43
caatccgccc aaagggaac                                                    19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  44
ctctgctcgg atcgaggtct                                                   20


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  45
gatgcaggtg ggagtgagg                                                    19


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  46
ttccccgacc cccttcagtg                                                   20


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  47
aggatgggtc actgtgtccg t                                                 21


<210>  48
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  48
tggccgacct cacttcc                                                      17


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for cDNA amplification

<400>  49
aagtaaaaca aatagtcacc tctgc                                             25


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  50
gtaagcaccc gctgtagccc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  51
ctatcacctt cttcaccgtc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  52
cctgctaggc accatggctg                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  53
aatccgctgc gcccccagcc a                                                 21


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  54
gcgcagcgga ttgcagcttc                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  55
tctgggaacg gctgttggct                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  56
tccagccatc ctcccgcacg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  57
tcttagctga ctacgcgtaa                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  58
gtccgagatc tcgaagcact                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  59
cagcgacact caccctccgg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence for the validation of critical mutation

<400>  60
ccttttcctg aatgaagatc                                                   20


<210>  61
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  61
tttttgtggt cttatgtggc ctgttttgtg ttttcctctg atcttaacag ttccgccatg       60

gagtcatagt tgcagctgac agcaacgcta cagcgggtgc ttacattgcc tcccagacg       119


<210>  62
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  62
tttttgtggt cttatgtggc ctgttttgtg ttttcctctg atcttaacag ttccgccatg       60

gagtcatagt tgcagctgac agcagggctg ccgcgggtgc ttacattgcc tcccagacg       119


<210>  63
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  63
tttcctctga tcttaacagt tccgccatgg agtcatagtt gcagctgact ccagggctac       60

agcgggtgct tacattgcct cacagacggc caagaaggtg atagagatca acccatacc       119


<210>  64
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  64
agatgcgttc cttatttcga agctcataga ttcgacattg ccgagccaac agccgttccc       60

agaagctgca atccgctgcg ccgccagcga tggtgcctag caggtatggg ttgatctct       119


<210>  65
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  65
actccagggc tacagcgggt gcttacattg cctcccagac ggtgaagaag gtgatagaga       60

tcaacccata cctgctaggc acaatggctg ggggcaccgc ggattgcagc ttctgggaa       119


<210>  66
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  66
cagtttggag gcagctgcta cagagatgcg ttccttattt cgaagctcat agattcgaca       60

ttgccgagcc aacagccgtt cccagaagct gcaggccgct gcgcccccag ccatggtgc       119


<210>  67
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  67
cagtttggag gcagctgcta cagagatgcg ttccttattt cgaagctcat agattcgaca       60

ttgccgagcc aacagccgtt cccagaagct ggcatccgct gcgcccccag ccatggtgc       119


<210>  68
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  68
atacaccatg ttggcaagca gtttggaggc agctgctaca gagatgcgtt ccttatttcg       60

aagctcatag attcggaatt ggcgagccaa cagccgttcc cagaagctgc aatccgctg       119


<210>  69
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  69
gcaggcctat gatctggccc gtcgagccat ctaccaagcc acctacagag atgcctactc       60

aggaggtgca gtcaacctct atcacgtgcg ggaggatgac tggatccgag tctccagtg       119


<210>  70
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  70
cgcagcctcg cccaccagca cgtcgtagga ttccacggct ttttcgagga caacgacttc       60

gtgttcgtgg tgttggagct ctgtagcagg gtgagtgtcg ctgctgggga actggaact       119


<210>  71
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  71
aagagatccc ggaggtccta gtggacccac gcagccggcg gcgctatgtg cggggccgct       60

ttttgggcaa gggcggcttt gcaaaggtgt tcgagatctc ggacgcggac accaaggag       119


<210>  72
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  72
cagcctcgcc caccagcacg tcgtaggatt ccacggcttt ttcgaggaca acgacttcgt       60

gttcgtggtg ttggagctct gtaggcgggg cgtgagtgtc gctgctgggg aactggaac       119


<210>  73
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  73
ctcccagcct cctccaaatt ccagcctctt gtagtgatgt caagcacccc tgcaggctca       60

gcaactcacc tattttcacc tcgagatctt cattcagcag aaggttgccc agcttgagg       119


<210>  74
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN donor encoded one amino acid substitution for a validated 
       residue

<400>  74
actccagggc tacagcgggt gcttacattg cctcccagac ggtgaagaag gtgatagaga       60

tcaacccata cctgctaggc acaatggctg ggggcgcgga ttgcagcttc tgggaacgg       119


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  75
gtgtttttgt ggtcttatgt ggcc                                              24


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  76
catgtggttg cagcttaact cac                                               23


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  77
gatgtgaagc tcgggtgaca tt                                                22


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  78
tcagcattga caccaagccc ttt                                               23


<210>  79
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  79
ctgctaacct catctccctt tccag                                             25


<210>  80
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplification of mutated loci in PSMB5 gene

<400>  80
caagcagctg catccaccct ctt                                               23


<210>  81
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  81
gcagctgact ccagggctac agcg                                              24


<210>  82
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  82
gcagctgact ccagggctnc ngcg                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  83
attgcctccc agacggtgaa gaag                                              24


<210>  84
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  84
ctaggcacca tggctggggg cgca                                              24


<210>  85
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<400>  85
ctaggcacca tngctggggg cgca                                              24


<210>  86
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  86
ggcaccatgg ctgggggcgc agcg                                              24


<210>  87
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  87
ggcaccatgg ctgggggcnc ngcg                                              24


<210>  88
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  88
ctgttggctc ggcaatgtcg aatc                                              24


<210>  89
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<400>  89
ctgttggctc gccaatnccg aatc                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  90
ctctaccacg tgcgggagga tggc                                              24


<210>  91
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, or t

<400>  91
ctctancacg tgcgggagga tgnc                                              24


<210>  92
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  92

Ala Ala Asp Ser Arg Ala Thr Ala 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  X represents N or S

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  93

Ala Ala Asp Ser Xaa Ala Thr Ala 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Ala Asp Ser Arg Ala Ala Ala 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  95

Ile Ala Ser Gln Thr Val Lys Lys 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  X represents A or L

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Ile Ala Ser Gln Thr Xaa Lys Lys 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  97

Leu Gly Thr Met Ala Gly Gly Ala 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  X represents I or V

<220>
<221>  MISC_FEATURE
<223>  Xaa represents Ile or Val

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Leu Gly Thr Xaa Ala Gly Gly Ala 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Thr Met Ala Gly Gly Ala Ala 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Thr Met Ala Gly Gly Thr Ala 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  101

Leu Leu Ala Arg Gln Cys Arg Ile 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  102

Leu Leu Ala Arg Gln Phe Arg Ile 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  103

Leu Tyr His Val Arg Glu Asp Gly 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  104

Leu Tyr His Val Arg Glu Asp Asp 
1               5               


<210>  105
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  105
tgactccagg gctacagcgg gtgcttacat tgc                                    33


<210>  106
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (5)..(6)
<223>  substitutions

<220>
<221>  mutation
<222>  (8)..(10)
<223>  substitutions

<400>  106
tgacagcaac gctacagcgg gtgcttacat tgc                                    33


<210>  107
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  107
gcctcccaga cggtgaagaa ggtgatagag atc                                    33


<210>  108
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (13)..(15)
<223>  substitutions

<400>  108
gcctcccaga cgttgaagaa ggtgatagag atc                                    33


<210>  109
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  109
aggcaccatg gctgggggcg cagcggattg cag                                    33


<210>  110
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (7)..(7)
<223>  substitution

<220>
<221>  mutation
<222>  (20)..(22)
<223>  substitutions

<400>  110
aggcacaatg gctgggggca ccgcggattg cag                                    33


<210>  111
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  111
agcttctggg aacggctgtt ggctcggcaa tgt                                    33


<210>  112
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (27)..(27)
<223>  substitution

<220>
<221>  mutation
<222>  (31)..(33)
<223>  substitutions

<400>  112
agcttctggg aacggctgtt ggctcgccaa ttc                                    33


<210>  113
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  113
ctctaccacg tgcgggagga tggctggatc cga                                    33


<210>  114
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mutation
<222>  (6)..(6)
<223>  substitution

<220>
<221>  mutation
<222>  (22)..(24)
<223>  substitutions

<400>  114
ctctatcacg tgcgggagga tgactggatc cga                                    33



