               SEQUENCE LISTING

<110> INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE  MEDICALE
      UNIVERSITE DE PARIS
      SORBONNE UNIVERSITE
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

<120> NEW INHIBITORS OF LRRK2/PP1 INTERACTION

<130> 542

<150> EP19305365.9
<151> 2019-03-22

<160> 30

<170> BiSSAP 1.3.6

<210> 1
<211> 2527
<212> PRT
<213> Homo sapiens


<400> 1
Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      
Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          
Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              
Glu His Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  
Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  
Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      
Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         
Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             
Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 
Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 
Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     
Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         
Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             
Leu Ser Ala Ser Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 
Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 
Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     
Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         
Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             
Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 
Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 
Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     
Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         
Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             
Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 
His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 
Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     
Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         
Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             
Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 
Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 
Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     
Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         
Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             
Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 
Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 
Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     
Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         
Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             
Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 
His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 
Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     
Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         
Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             
Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 
Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 
Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     
Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         
Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             
Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 
Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 
Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     
Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         
Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             
Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 
Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 
Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     
Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         
Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             
Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 
Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 
Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     
Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         
Glu Leu Arg Asp Ile Asp Ala Leu Ser Gln Lys Cys Cys Ile Ser Val 
        995                 1000                1005            
His Leu Glu His Leu Glu Lys Leu Glu Leu His Gln Asn Ala Leu Thr 
    1010                1015                1020                
Ser Phe Pro Gln Gln Leu Cys Glu Thr Leu Lys Ser Leu Thr His Leu 
1025                1030                1035                1040
Asp Leu His Ser Asn Lys Phe Thr Ser Phe Pro Ser Tyr Leu Leu Lys 
                1045                1050                1055    
Met Ser Cys Ile Ala Asn Leu Asp Val Ser Arg Asn Asp Ile Gly Pro 
            1060                1065                1070        
Ser Val Val Leu Asp Pro Thr Val Lys Cys Pro Thr Leu Lys Gln Phe 
        1075                1080                1085            
Asn Leu Ser Tyr Asn Gln Leu Ser Phe Val Pro Glu Asn Leu Thr Asp 
    1090                1095                1100                
Val Val Glu Lys Leu Glu Gln Leu Ile Leu Glu Gly Asn Lys Ile Ser 
1105                1110                1115                1120
Gly Ile Cys Ser Pro Leu Arg Leu Lys Glu Leu Lys Ile Leu Asn Leu 
                1125                1130                1135    
Ser Lys Asn His Ile Ser Ser Leu Ser Glu Asn Phe Leu Glu Ala Cys 
            1140                1145                1150        
Pro Lys Val Glu Ser Phe Ser Ala Arg Met Asn Phe Leu Ala Ala Met 
        1155                1160                1165            
Pro Phe Leu Pro Pro Ser Met Thr Ile Leu Lys Leu Ser Gln Asn Lys 
    1170                1175                1180                
Phe Ser Cys Ile Pro Glu Ala Ile Leu Asn Leu Pro His Leu Arg Ser 
1185                1190                1195                1200
Leu Asp Met Ser Ser Asn Asp Ile Gln Tyr Leu Pro Gly Pro Ala His 
                1205                1210                1215    
Trp Lys Ser Leu Asn Leu Arg Glu Leu Leu Phe Ser His Asn Gln Ile 
            1220                1225                1230        
Ser Ile Leu Asp Leu Ser Glu Lys Ala Tyr Leu Trp Ser Arg Val Glu 
        1235                1240                1245            
Lys Leu His Leu Ser His Asn Lys Leu Lys Glu Ile Pro Pro Glu Ile 
    1250                1255                1260                
Gly Cys Leu Glu Asn Leu Thr Ser Leu Asp Val Ser Tyr Asn Leu Glu 
1265                1270                1275                1280
Leu Arg Ser Phe Pro Asn Glu Met Gly Lys Leu Ser Lys Ile Trp Asp 
                1285                1290                1295    
Leu Pro Leu Asp Glu Leu His Leu Asn Phe Asp Phe Lys His Ile Gly 
            1300                1305                1310        
Cys Lys Ala Lys Asp Ile Ile Arg Phe Leu Gln Gln Arg Leu Lys Lys 
        1315                1320                1325            
Ala Val Pro Tyr Asn Arg Met Lys Leu Met Ile Val Gly Asn Thr Gly 
    1330                1335                1340                
Ser Gly Lys Thr Thr Leu Leu Gln Gln Leu Met Lys Thr Lys Lys Ser 
1345                1350                1355                1360
Asp Leu Gly Met Gln Ser Ala Thr Val Gly Ile Asp Val Lys Asp Trp 
                1365                1370                1375    
Pro Ile Gln Ile Arg Asp Lys Arg Lys Arg Asp Leu Val Leu Asn Val 
            1380                1385                1390        
Trp Asp Phe Ala Gly Arg Glu Glu Phe Tyr Ser Thr His Pro His Phe 
        1395                1400                1405            
Met Thr Gln Arg Ala Leu Tyr Leu Ala Val Tyr Asp Leu Ser Lys Gly 
    1410                1415                1420                
Gln Ala Glu Val Asp Ala Met Lys Pro Trp Leu Phe Asn Ile Lys Ala 
1425                1430                1435                1440
Arg Ala Ser Ser Ser Pro Val Ile Leu Val Gly Thr His Leu Asp Val 
                1445                1450                1455    
Ser Asp Glu Lys Gln Arg Lys Ala Cys Met Ser Lys Ile Thr Lys Glu 
            1460                1465                1470        
Leu Leu Asn Lys Arg Gly Phe Pro Ala Ile Arg Asp Tyr His Phe Val 
        1475                1480                1485            
Asn Ala Thr Glu Glu Ser Asp Ala Leu Ala Lys Leu Arg Lys Thr Ile 
    1490                1495                1500                
Ile Asn Glu Ser Leu Asn Phe Lys Ile Arg Asp Gln Leu Val Val Gly 
1505                1510                1515                1520
Gln Leu Ile Pro Asp Cys Tyr Val Glu Leu Glu Lys Ile Ile Leu Ser 
                1525                1530                1535    
Glu Arg Lys Asn Val Pro Ile Glu Phe Pro Val Ile Asp Arg Lys Arg 
            1540                1545                1550        
Leu Leu Gln Leu Val Arg Glu Asn Gln Leu Gln Leu Asp Glu Asn Glu 
        1555                1560                1565            
Leu Pro His Ala Val His Phe Leu Asn Glu Ser Gly Val Leu Leu His 
    1570                1575                1580                
Phe Gln Asp Pro Ala Leu Gln Leu Ser Asp Leu Tyr Phe Val Glu Pro 
1585                1590                1595                1600
Lys Trp Leu Cys Lys Ile Met Ala Gln Ile Leu Thr Val Lys Val Glu 
                1605                1610                1615    
Gly Cys Pro Lys His Pro Lys Gly Ile Ile Ser Arg Arg Asp Val Glu 
            1620                1625                1630        
Lys Phe Leu Ser Lys Lys Arg Lys Phe Pro Lys Asn Tyr Met Ser Gln 
        1635                1640                1645            
Tyr Phe Lys Leu Leu Glu Lys Phe Gln Ile Ala Leu Pro Ile Gly Glu 
    1650                1655                1660                
Glu Tyr Leu Leu Val Pro Ser Ser Leu Ser Asp His Arg Pro Val Ile 
1665                1670                1675                1680
Glu Leu Pro His Cys Glu Asn Ser Glu Ile Ile Ile Arg Leu Tyr Glu 
                1685                1690                1695    
Met Pro Tyr Phe Pro Met Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu 
            1700                1705                1710        
Leu Glu Ile Ser Pro Tyr Met Leu Ser Gly Arg Glu Arg Ala Leu Arg 
        1715                1720                1725            
Pro Asn Arg Met Tyr Trp Arg Gln Gly Ile Tyr Leu Asn Trp Ser Pro 
    1730                1735                1740                
Glu Ala Tyr Cys Leu Val Gly Ser Glu Val Leu Asp Asn His Pro Glu 
1745                1750                1755                1760
Ser Phe Leu Lys Ile Thr Val Pro Ser Cys Arg Lys Gly Cys Ile Leu 
                1765                1770                1775    
Leu Gly Gln Val Val Asp His Ile Asp Ser Leu Met Glu Glu Trp Phe 
            1780                1785                1790        
Pro Gly Leu Leu Glu Ile Asp Ile Cys Gly Glu Gly Glu Thr Leu Leu 
        1795                1800                1805            
Lys Lys Trp Ala Leu Tyr Ser Phe Asn Asp Gly Glu Glu His Gln Lys 
    1810                1815                1820                
Ile Leu Leu Asp Asp Leu Met Lys Lys Ala Glu Glu Gly Asp Leu Leu 
1825                1830                1835                1840
Val Asn Pro Asp Gln Pro Arg Leu Thr Ile Pro Ile Ser Gln Ile Ala 
                1845                1850                1855    
Pro Asp Leu Ile Leu Ala Asp Leu Pro Arg Asn Ile Met Leu Asn Asn 
            1860                1865                1870        
Asp Glu Leu Glu Phe Glu Gln Ala Pro Glu Phe Leu Leu Gly Asp Gly 
        1875                1880                1885            
Ser Phe Gly Ser Val Tyr Arg Ala Ala Tyr Glu Gly Glu Glu Val Ala 
    1890                1895                1900                
Val Lys Ile Phe Asn Lys His Thr Ser Leu Arg Leu Leu Arg Gln Glu 
1905                1910                1915                1920
Leu Val Val Leu Cys His Leu His His Pro Ser Leu Ile Ser Leu Leu 
                1925                1930                1935    
Ala Ala Gly Ile Arg Pro Arg Met Leu Val Met Glu Leu Ala Ser Lys 
            1940                1945                1950        
Gly Ser Leu Asp Arg Leu Leu Gln Gln Asp Lys Ala Ser Leu Thr Arg 
        1955                1960                1965            
Thr Leu Gln His Arg Ile Ala Leu His Val Ala Asp Gly Leu Arg Tyr 
    1970                1975                1980                
Leu His Ser Ala Met Ile Ile Tyr Arg Asp Leu Lys Pro His Asn Val 
1985                1990                1995                2000
Leu Leu Phe Thr Leu Tyr Pro Asn Ala Ala Ile Ile Ala Lys Ile Ala 
                2005                2010                2015    
Asp Tyr Gly Ile Ala Gln Tyr Cys Cys Arg Met Gly Ile Lys Thr Ser 
            2020                2025                2030        
Glu Gly Thr Pro Gly Phe Arg Ala Pro Glu Val Ala Arg Gly Asn Val 
        2035                2040                2045            
Ile Tyr Asn Gln Gln Ala Asp Val Tyr Ser Phe Gly Leu Leu Leu Tyr 
    2050                2055                2060                
Asp Ile Leu Thr Thr Gly Gly Arg Ile Val Glu Gly Leu Lys Phe Pro 
2065                2070                2075                2080
Asn Glu Phe Asp Glu Leu Glu Ile Gln Gly Lys Leu Pro Asp Pro Val 
                2085                2090                2095    
Lys Glu Tyr Gly Cys Ala Pro Trp Pro Met Val Glu Lys Leu Ile Lys 
            2100                2105                2110        
Gln Cys Leu Lys Glu Asn Pro Gln Glu Arg Pro Thr Ser Ala Gln Val 
        2115                2120                2125            
Phe Asp Ile Leu Asn Ser Ala Glu Leu Val Cys Leu Thr Arg Arg Ile 
    2130                2135                2140                
Leu Leu Pro Lys Asn Val Ile Val Glu Cys Met Val Ala Thr His His 
2145                2150                2155                2160
Asn Ser Arg Asn Ala Ser Ile Trp Leu Gly Cys Gly His Thr Asp Arg 
                2165                2170                2175    
Gly Gln Leu Ser Phe Leu Asp Leu Asn Thr Glu Gly Tyr Thr Ser Glu 
            2180                2185                2190        
Glu Val Ala Asp Ser Arg Ile Leu Cys Leu Ala Leu Val His Leu Pro 
        2195                2200                2205            
Val Glu Lys Glu Ser Trp Ile Val Ser Gly Thr Gln Ser Gly Thr Leu 
    2210                2215                2220                
Leu Val Ile Asn Thr Glu Asp Gly Lys Lys Arg His Thr Leu Glu Lys 
2225                2230                2235                2240
Met Thr Asp Ser Val Thr Cys Leu Tyr Cys Asn Ser Phe Ser Lys Gln 
                2245                2250                2255    
Ser Lys Gln Lys Asn Phe Leu Leu Val Gly Thr Ala Asp Gly Lys Leu 
            2260                2265                2270        
Ala Ile Phe Glu Asp Lys Thr Val Lys Leu Lys Gly Ala Ala Pro Leu 
        2275                2280                2285            
Lys Ile Leu Asn Ile Gly Asn Val Ser Thr Pro Leu Met Cys Leu Ser 
    2290                2295                2300                
Glu Ser Thr Asn Ser Thr Glu Arg Asn Val Met Trp Gly Gly Cys Gly 
2305                2310                2315                2320
Thr Lys Ile Phe Ser Phe Ser Asn Asp Phe Thr Ile Gln Lys Leu Ile 
                2325                2330                2335    
Glu Thr Arg Thr Ser Gln Leu Phe Ser Tyr Ala Ala Phe Ser Asp Ser 
            2340                2345                2350        
Asn Ile Ile Thr Val Val Val Asp Thr Ala Leu Tyr Ile Ala Lys Gln 
        2355                2360                2365            
Asn Ser Pro Val Val Glu Val Trp Asp Lys Lys Thr Glu Lys Leu Cys 
    2370                2375                2380                
Gly Leu Ile Asp Cys Val His Phe Leu Arg Glu Val Met Val Lys Glu 
2385                2390                2395                2400
Asn Lys Glu Ser Lys His Lys Met Ser Tyr Ser Gly Arg Val Lys Thr 
                2405                2410                2415    
Leu Cys Leu Gln Lys Asn Thr Ala Leu Trp Ile Gly Thr Gly Gly Gly 
            2420                2425                2430        
His Ile Leu Leu Leu Asp Leu Ser Thr Arg Arg Leu Ile Arg Val Ile 
        2435                2440                2445            
Tyr Asn Phe Cys Asn Ser Val Arg Val Met Met Thr Ala Gln Leu Gly 
    2450                2455                2460                
Ser Leu Lys Asn Val Met Leu Val Leu Gly Tyr Asn Arg Lys Asn Thr 
2465                2470                2475                2480
Glu Gly Thr Gln Lys Gln Lys Glu Ile Gln Ser Cys Leu Thr Val Trp 
                2485                2490                2495    
Asp Ile Asn Leu Pro His Glu Val Gln Asn Leu Glu Lys His Ile Glu 
            2500                2505                2510        
Val Arg Lys Glu Leu Ala Glu Lys Met Arg Arg Thr Ser Val Glu 
        2515                2520                2525        

<210> 2
<211> 10
<212> PRT
<213> Homo sapiens


<400> 2
Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
1               5                   10  

<210> 3
<211> 11
<212> PRT
<213> Homo sapiens


<400> 3
Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
1               5                   10      

<210> 4
<211> 13
<212> PRT
<213> Homo sapiens


<400> 4
Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
1               5                   10              

<210> 5
<211> 9
<212> PRT
<213> Homo sapiens


<400> 5
Pro Met Gly Phe Trp Ser Arg Leu Ile 
1               5                   

<210> 6
<211> 16
<212> PRT
<213> Homo sapiens


<400> 6
Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
1               5                   10                  15      



<210> 7
<211> 18
<212> PRT
<213> Homo sapiens


<400> 7
Pro Met Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser 
1               5                   10                  15      
Pro Tyr 
        

<210> 8
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> seq_8

<400> 8
Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile 
1               5                   10              

<210> 9
<211> 15
<212> PRT
<213> Homo sapiens


<400> 9
Pro Met Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile 
1               5                   10                  15  

<210> 10
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> seq_29 fused to seq_2

<400> 10
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Asn Arg Leu Leu 
1               5                   10                  15      
Glu Ile Ser Pro Tyr 
            20      

<210> 11
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> seq_29 fused to seq_3

<400> 11
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Leu Ile Asn Arg 
1               5                   10                  15      
Leu Leu Glu Ile Ser Pro Tyr 
            20              

<210> 12
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to seq_4

<400> 12
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Ser Arg Leu Ile 
1               5                   10                  15      
Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25  

<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to seq_5

<400> 13
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile 
            20      

<210> 14
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to seq_7

<400> 14
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25                  30  

<210> 15
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to seq_8

<400> 15
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Gly Phe Trp Ser 
1               5                   10                  15      
Arg Leu Ile Asn Arg Leu Leu Glu Ile 
            20                  25  

<210> 16
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to Seq_6

<400> 16
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Gly Phe Trp Ser 
1               5                   10                  15      
Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25              

<210> 17
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_29 fused to Seq_9

<400> 17
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile 
            20                  25          

<210> 18
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_2

<400> 18
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Ile Asn Arg Leu 
1               5                   10                  15      
Leu Glu Ile Ser Pro Tyr 
            20          

<210> 19
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_3

<400> 19
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Leu Ile Asn Arg 
1               5                   10                  15      
Leu Leu Glu Ile Ser Pro Tyr 
            20              

<210> 20
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_4

<400> 20
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Ser Arg Leu Ile 
1               5                   10                  15      
Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25  

<210> 21
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_5

<400> 21
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile 
            20      

<210> 22
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_6

<400> 22
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Gly Phe Trp Ser 
1               5                   10                  15      
Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25              

<210> 23
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_7

<400> 23
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25                  30  

<210> 24
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_8

<400> 24
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Gly Phe Trp Ser 
1               5                   10                  15      
Arg Leu Ile Asn Arg Leu Leu Glu Ile 
            20                  25  

<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_5

<400> 25
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Met Gly Phe Trp 
1               5                   10                  15      
Ser Arg Leu Ile 
            20  

<210> 26
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_7

<400> 26
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Met Gly Phe Trp 
1               5                   10                  15      
Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr 
            20                  25                  

<210> 27
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq_30 fused to Seq_9

<400> 27
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Met Gly Phe Trp 
1               5                   10                  15      
Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile 
            20                  25      

<210> 28
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq 30 fused to Seq_9

<400> 28
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro Pro Met Gly Phe 
1               5                   10                  15      
Trp Ser Arg Leu Ile Asn Arg Leu Leu Glu Ile 
            20                  25          

<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> vectorization (or carrier) peptides disclosed in WO/2016/156536

<400> 29
Val Lys Lys Lys Lys Ile Lys Ala Glu Ile Lys Ile 
1               5                   10          

<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide BBB shuttle THR from table 1 of Oller-Salvia et al (2016)

<400> 30
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          

