                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       AMIT, Ido
       ELINAV, Eran
       JAITIN, Diego
       WEINER, Assaf
       SHAPIRO, Hagit
       THAISS, Christoph Alexander
       ADLUNG, Lorenz Kurt
 
<120>  METHOD OF TREATING LIPID-RELATED DISORDERS

<130>  81583

<150>  US 62/825,112
<151>  2019-03-28

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  2
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain variable region of Ab21

<400>  2

Glu Val Gln Leu Val Gln Ser Cys Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly His Tyr Asp Gly Gly His Leu Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  3

Tyr Ser Phe Thr Thr Tyr Trp Ile Gly 
1               5                   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  4

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  5

Ala Arg Ala Gly His Tyr Asp Gly Gly His Leu Gly Met Asp Val 
1               5                   10                  15  


<210>  6
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain variable region of Ab52

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Asp Asp Ser Ser Gly Tyr Pro Leu Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  7
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  7

Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  8

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  9

Ala Arg Glu Ala Asp Asp Ser Ser Gly Tyr Pro Leu Gly Leu Asp Val 
1               5                   10                  15      


<210>  10
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain variable region of Ab21

<400>  10

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Asp Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  11

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  12
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  12

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  13

Gln Gln Asp Asp Ser Ala Pro Tyr Thr Phe 
1               5                   10  


<210>  14
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain variable region of Ab52

<400>  14

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Val Asn Ser Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  15

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  16

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  17

Gln Gln Val Asn Ser Leu Pro Pro Thr 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  18

Gly Phe Thr Phe Thr Asp Phe Tyr 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  19

Ile Arg Asn Lys Thr Lys Gly Tyr Thr Thr 
1               5                   10  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  20

Ala Arg Ile Gly Val Asn Asn Gly Gly Ser Leu Asp Tyr Trp Gly 
1               5                   10                  15  


<210>  21
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  21

Gln Ser Leu Leu Tyr Ser Glu Asn Asn Gln Asp Tyr 
1               5                   10          


<210>  22
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  22

Gly Ala Ser 
1           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  23

Glu Gln Thr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  24

Gly Phe Thr Phe Thr Asp Phe Tyr 
1               5               


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  25

Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  26

Ala Arg Ile Gly Ile Asn Asn Gly Gly Ser Leu Asp Tyr Trp Gly 
1               5                   10                  15  


<210>  27
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  27

Gln Ser Leu Leu Tyr Ser Glu Lys Asn Gln Asp Tyr 
1               5                   10          


<210>  28
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  28

Gly Ala Ser 
1           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  29

Glu Gln Thr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  30

Gly Phe Thr Phe Thr Asp Phe Tyr 
1               5               


<210>  31
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  31

Ile Arg Asn Lys Ala Tyr Gly Tyr Thr Thr 
1               5                   10  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  32

Ala Arg Ile Gly Ile Asn Tyr Gly Gly Ser Leu Asp Tyr Trp Gly 
1               5                   10                  15  


<210>  33
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  33

Gln Ser Leu Leu Tyr Ser Glu Ser Asn Gln Asp Tyr 
1               5                   10          


<210>  34
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  34

Gly Ala Ser 
1           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining regions (CDRs)

<400>  35

Glu Gln Thr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


