                         SEQUENCE LISTING

<110>  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120>  COMPOSITIONS AND METHODS FOR GENETICALLY-ENCODED HIGH 
       VOLTAGE-ACTIVATED CALCIUM CHANNEL BLOCKERS USING ENGINEERED 
       UBIQUITIN LIGASES

<130>  Provisional

<140>  US 62/883,637
<141>  2019-08-06

<160>  98    
<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  1

Ser Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5                   


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  2

Val Ser Cys Phe Ser Ser Ser Asp Gly Ser 
1               5                   10  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  3

Ile Glu Gly Met Arg Ile Ser Pro Val Val Thr Gly Ile Pro Ala Phe 
1               5                   10                  15      


Asp Phe Gly Ser 
            20  


<210>  4
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Phe Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Glu Gly Met Arg Ile Ser Pro Val Val Thr Gly Ile Pro 
            100                 105                 110         


Ala Phe Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  5

Ser Gly Arg Thr Phe Ser Ser Tyr Thr 
1               5                   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  6

Ile Ser Trp Ser Gly Gly 
1               5       


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  7

Asp Thr Tyr Tyr Gly Ser Arg Met Trp Asn Glu 
1               5                   10      


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ala Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Tyr Tyr Gly Ser Arg Met Trp Asn Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  9

Ser Gly Ser Ile Leu Thr Ile Asn Val 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  10

His Ala Ser Ser Gly Gly Ser 
1               5           


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  11

Thr Leu Tyr Met Arg Thr Glu Ala Gln Ser Arg Gly Thr Gly 
1               5                   10                  


<210>  12
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Ile Leu Thr Ile Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala His Ala Ser Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Trp Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Leu Tyr Met Arg Thr Glu Ala Gln Ser Arg Gly Thr Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  13

Ser Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5                   


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  14

Ile Glu Arg Ser Gly Gly Thr Ala Ser His 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  15

Ser Ser Tyr Trp Ser Arg Ser Val Ala Glu 
1               5                   10  


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Glu Arg Ser Gly Gly Thr Ala Ser His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Ser Ser Tyr Trp Ser Arg Ser Val Ala Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  17

Ser Glu Arg Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  18

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  19

His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala 
1               5                   10      


<210>  20
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala Tyr Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  21

Ser Glu Arg Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  22

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  23

His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala 
1               5                   10      


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  25

Ser Gly Arg Thr Phe Ser Arg Asn Ala 
1               5                   


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  26

Ile Ser Trp Ser Gly Arg Asn 
1               5           


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  27

Val Gly Ala Asp Trp Arg Val Tyr Asp Glu Ser Tyr Tyr Ser Thr Ala 
1               5                   10                  15      


His Tyr Tyr Glu Tyr 
            20      


<210>  28
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Ile Cys 
                85                  90                  95      


Ala Val Gly Ala Asp Trp Arg Val Tyr Asp Glu Ser Tyr Tyr Ser Thr 
            100                 105                 110         


Ala His Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  29

Ser Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  30

Ile Glu Arg Ser Gly Gly Thr Ala Ser His 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  31

Ser Ser Tyr Trp Ser Arg Ser Val Asp Glu 
1               5                   10  


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Gly Gly Gly 
1               5                   10                  15      


Ser Arg Arg Phe Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Glu Arg Ser Gly Gly Thr Ala Ser His Ala Asp Ser Lys 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Gln Gln Met Asn Ser Lys Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Tyr Trp Ser Arg Ser Val Asp Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  33

Ser Glu Arg Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  34

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  35

His Tyr Gln Gly Ser Tyr Gly Ser Ala Ser Ala 
1               5                   10      


<210>  36
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Thr Val Asn 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Gln Gly Ser Tyr Gly Ser Ala Ser Ala Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  37

Ser Gly Arg Thr Phe Ser Pro Tyr Ala 
1               5                   


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  38

Ile Thr Trp Ser Gly Gly Leu 
1               5           


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  39

Cys Ala Leu Asp Asp Asp Thr Phe Gly Val Thr Thr Ser Thr His 
1               5                   10                  15  


<210>  40
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Asp Asp Thr Phe Gly Val Thr Thr Ser Thr His Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  41

Ser Gly Arg Thr Phe Ser Lys Asn Ala 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  42

Val Ala Ile Ser Trp Ser Gly Arg Asn 
1               5                   


<210>  43
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  43

Cys Ala Val Gly Gly Asp Trp Arg Val Tyr Asp Ile Ser Phe Tyr Tyr 
1               5                   10                  15      


Thr Ala His Gln Tyr Glu 
            20          


<210>  44
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Lys Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Ser Trp Ser Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Gly Asp Trp Arg Val Tyr Asp Ile Ser Phe Tyr Tyr Thr 
            100                 105                 110         


Ala His Gln Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  45

Ser Leu Gly Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  46

Val Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Leu Tyr 
1               5                   10              


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  47

Glu Val Phe Tyr Ser Gly Ser Tyr Asp Asp Thr Leu Arg Val Gln Ser 
1               5                   10                  15      


His Glu 
        


<210>  48
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Leu Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Val Phe Tyr Ser Gly Ser Tyr Asp Asp Thr Leu Arg Val 
            100                 105                 110         


Gln Ser His Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  49

Ser Gly Arg Thr Phe Ser Ser Tyr Thr 
1               5                   


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  50

Ile Ser Trp Ser Gly Gly Thr 
1               5           


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  51

Asp Thr Tyr Tyr Gly Ser Arg Met Trp Asn Glu 
1               5                   10      


<210>  52
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ala Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Tyr Tyr Gly Ser Arg Met Trp Asn Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  53

Ser Glu Arg Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  54

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  55
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Ser 
65                  70          


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  56

Ser Gly Arg Thr Phe Ser Arg Asn Ala 
1               5                   


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  57

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  58
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Ser 
65                  70          


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  59

Ser Glu Arg Thr Phe Ser Arg Tyr Ala 
1               5                   


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  60

Ile Asn Trp Ser Gly Ser Ser 
1               5           


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  61

His Tyr Gln Gly Ser Tyr Gly Ser Ala Ser Ala 
1               5                   10      


<210>  62
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Thr Val Asn 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Gln Gly Ser Tyr Gly Ser Ala Ser Ala Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  63

Ser Gly Phe Ser Phe Asp Asp Tyr Thr Leu Gly 
1               5                   10      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  64

Val Ser Cys Ile Ser Ser Ser Asp Gly Ser 
1               5                   10  


<210>  65
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  65

Val Val Gly Leu Arg Leu Pro Thr Tyr Ala Ser Asn Ser Cys Lys Ile 
1               5                   10                  15      


Val Ala Asp Phe Gly Ser 
            20          


<210>  66
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Asp Tyr 
            20                  25                  30          


Thr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Gly Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Val Gly Leu Arg Leu Pro Thr Tyr Ala Ser Asn Ser Cys 
            100                 105                 110         


Lys Ile Val Ala Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  67

Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5                   10      


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  68

Ile Asp Trp Ser Gly Gly Thr Ala Ser His 
1               5                   10  


<210>  69
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  69

Cys Ala Val Gly Gly Asp Trp Arg Val Tyr Asp Ile Ser Phe Tyr Tyr 
1               5                   10                  15      


Thr Ala His Gln Tyr Glu 
            20          


<210>  70
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  70

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Gly Gly Thr Ala Ser His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Gly Asp Trp Arg Val Tyr Asp Ile Ser Phe Tyr Tyr Thr 
            100                 105                 110         


Ala His Gln Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  71

Ser Gly Arg Thr Phe Ser Arg Asn Ala 
1               5                   


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  72

Ile Ser Trp Ser Gly Arg Asn 
1               5           


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  73

His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala 
1               5                   10      


<210>  74
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Gln Gly Ser Tyr Gly Ser Ala Leu Ala Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  75

Ser Gly Arg Thr Phe Ser Asn Phe Ala 
1               5                   


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  76

Ile Thr Trp Ser Arg Gly Ser 
1               5           


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  77

Gly Leu Trp Arg Tyr Tyr Thr Glu Ser Tyr Phe Tyr Thr Glu Asp Arg 
1               5                   10                  15      


<210>  78
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Arg Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Trp Arg Tyr Tyr Thr Glu Ser Tyr Phe Tyr Thr Glu 
            100                 105                 110         


Asp Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  79

Ala Val Ser Gly Phe Thr Leu Asp Asn Tyr Ala Ile 
1               5                   10          


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  80

Val Ser Cys Ile Ser Ser Ser Asp Gly Ser 
1               5                   10  


<210>  81
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  81

Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val Glu 
1               5                   10                  15      


Arg Asp Asp 
            


<210>  82
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val 
            100                 105                 110         


Glu Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  83

Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5                   10      


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  84

Ile Asp Trp Ser Gly Gly Thr Ala Ser His 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  85

Ser Ser Tyr Trp Ser Arg Ser Val Asp Glu 
1               5                   10  


<210>  86
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  86

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Gly Gly Thr Ala Ser His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Tyr Trp Ser Arg Ser Val Asp Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  87

Ser Gly Phe Thr Leu Asp Asn Tyr Ala Ile Gly 
1               5                   10      


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  88

Val Ser Cys Ile Ser Ser Ser Asp Gly Ser 
1               5                   10  


<210>  89
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  89

Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val Glu 
1               5                   10                  15      


Arg Asp Asp 
            


<210>  90
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  90

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val 
            100                 105                 110         


Glu Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  91

Ser Gly Phe Thr Leu Asp Asn Tyr Ala Ile Gly 
1               5                   10      


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  92

Val Ser Cys Ile Ser Ser Ser Asp Gly Ser 
1               5                   10  


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  93

Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val Glu 
1               5                   10                  15      


Arg Asp Asp 
            


<210>  94
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Glu Gln Val Trp Lys Thr Leu Phe Ser Ser Cys Thr Val 
            100                 105                 110         


Glu Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  95

Ser Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5                   


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  96

Ile Asp Trp Ser Gly Gly Thr Ser Val His 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  97

Thr Ser Tyr Trp Ser Thr Ala Glu Tyr Glu 
1               5                   10  


<210>  98
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Gly Gly Thr Ser Val His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Ser Tyr Trp Ser Thr Ala Glu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


