                         SEQUENCE LISTING

<110>  ҽҩƼ޹˾
 
<120>  һֻεϸƱӦ

<130>  20DX0462FPPC

<160>  45    

<170>  PatentIn version 3.3

<210>  1
<211>  407
<212>  PRT
<213>  ˹

<220>  
<223>  HIL-6

<400>  1

Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
1               5                   10                  15      


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
            20                  25                  30          


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
        35                  40                  45              


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
    50                  55                  60                  


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
65                  70                  75                  80  


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
                85                  90                  95      


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
            100                 105                 110         


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
        115                 120                 125             


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
    130                 135                 140                 


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
145                 150                 155                 160 


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
                165                 170                 175     


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
            180                 185                 190         


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
        195                 200                 205             


Pro Pro Ala Arg Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Glu Pro 
    210                 215                 220                 


Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln 
225                 230                 235                 240 


Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu 
                245                 250                 255     


Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met 
            260                 265                 270         


Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro 
        275                 280                 285             


Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu 
    290                 295                 300                 


Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr 
305                 310                 315                 320 


Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg 
                325                 330                 335     


Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys 
            340                 345                 350         


Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala 
        355                 360                 365             


Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met 
    370                 375                 380                 


Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser 
385                 390                 395                 400 


Leu Arg Ala Leu Arg Gln Met 
                405         


<210>  2
<211>  1221
<212>  DNA
<213>  ˹

<220>  
<223>  HIL-6

<400>  2
ccccccgagg agccccagct ctcctgcttc cggaagagcc ccctcagcaa tgttgtttgt     60

gagtggggtc ctcggagcac cccatccctg acgacaaagg ctgtgctctt ggtgaggaag    120

tttcagaaca gtccggccga agacttccag gagccgtgcc agtattccca ggagtcccag    180

aagttctcct gccagttagc agtcccggag ggagacagct ctttctacat agtgtccatg    240

tgcgtcgcca gtagtgtcgg gagcaagttc agcaaaactc aaacctttca gggttgtgga    300

atcttgcagc ctgatccgcc tgccaacatc acagtcactg ccgtggccag aaacccccgc    360

tggctcagtg tcacctggca agacccccac tcctggaact catctttcta cagactacgg    420

tttgagctca gatatcgggc tgaacggtca aagacattca caacatggat ggtcaaggac    480

ctccagcatc actgtgtcat ccacgacgcc tggagcggcc tgaggcacgt ggtgcagctt    540

cgtgcccagg aggagttcgg gcaaggcgag tggagcgagt ggagcccgga ggccatgggc    600

acgccttgga cagaatccag gagtcctcca gctcgcggtg gtggatcagg aggtggaggg    660

tcagtcgagc cagtaccccc aggagaagat tccaaagatg tagccgcccc acacagacag    720

ccactcacct cttcagaacg aattgacaaa caaattcggt acatcctcga cggcatctca    780

gccctgagaa aggagacatg taacaagagt aacatgtgtg aaagcagcaa agaggcactg    840

gcagaaaaca acctgaacct tccaaagatg gctgaaaaag atggatgctt ccaatctgga    900

ttcaatgagg agacttgcct ggtgaaaatc atcactggtc ttttggagtt tgaggtatac    960

ctagagtacc tccagaacag atttgagagt agtgaggaac aagccagagc tgtgcagatg   1020

agtacaaaag tcctgatcca gttcctgcag aaaaaggcaa agaatctaga tgcaataacc   1080

acccctgacc caaccacaaa tgccagcctg ctgacgaagc tgcaggcaca gaaccagtgg   1140

ctgcaggaca tgacaactca tctcattctg cgcagcttta aggagttcct gcagtccagc   1200

ctgagggctc ttcggcaaat g                                             1221


<210>  3
<211>  344
<212>  PRT
<213>  ˹

<220>  
<223>  L-GP130

<400>  3

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
1               5                   10                  15      


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30          


Leu Lys Gln Lys Val Met Asn Ala Gln Gly Glu Ile Glu Ala Ile Val 
        35                  40                  45              


Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu 
    50                  55                  60                  


Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn 
65                  70                  75                  80  


Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr 
                85                  90                  95      


Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly 
            100                 105                 110         


Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys 
        115                 120                 125             


Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys 
    130                 135                 140                 


Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met 
145                 150                 155                 160 


Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser 
                165                 170                 175     


Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly 
            180                 185                 190         


Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser 
        195                 200                 205             


Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu 
    210                 215                 220                 


Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr 
225                 230                 235                 240 


Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His 
                245                 250                 255     


Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val 
            260                 265                 270         


Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser 
        275                 280                 285             


Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly 
    290                 295                 300                 


Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu 
305                 310                 315                 320 


Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val 
                325                 330                 335     


Arg Gln Gly Gly Tyr Met Pro Gln 
            340                 


<210>  4
<211>  1032
<212>  DNA
<213>  ˹

<220>  
<223>  L-GP130

<400>  4
cgtatcgctc gtctggaaga aaaagttaaa accctgaaag ctcagaactc cgaactggct     60

tccaccgcta acatgctgcg tgaacaggtt gctcagctga aacagaaagt tatgaacgct    120

caaggagaaa ttgaagccat agtcgtgcct gtttgcttag cattcctatt gacaactctt    180

ctgggagtgc tgttctgctt taataagcga gacctaatta aaaaacacat ctggcctaat    240

gttccagatc cttcaaagag tcatattgcc cagtggtcac ctcacactcc tccaaggcac    300

aattttaatt caaaagatca aatgtattca gatggcaatt tcactgatgt aagtgttgtg    360

gaaatagaag caaatgacaa aaagcctttt ccagaagatc tgaaatcatt ggacctgttc    420

aaaaaggaaa aaattaatac tgaaggacac agcagtggta ttggggggtc ttcatgcatg    480

tcatcttcta ggccaagcat ttctagcagt gatgaaaatg aatcttcaca aaacacttcg    540

agcactgtcc agtattctac cgtggtacac agtggctaca gacaccaagt tccgtcagtc    600

caagtcttct caagatccga gtctacccag cccttgttag attcagagga gcggccagaa    660

gatctacaat tagtagatca tgtagatggc ggtgatggta ttttgcccag gcaacagtac    720

ttcaaacaga actgcagtca gcatgaatcc agtccagata tttcacattt tgaaaggtca    780

aagcaagttt catcagtcaa tgaggaagat tttgttagac ttaaacagca gatttcagat    840

catatttcac aatcctgtgg atctgggcaa atgaaaatgt ttcaggaagt ttctgcagca    900

gatgcttttg gtccaggtac tgagggacaa gtagaaagat ttgaaacagt tggcatggag    960

gctgcgactg atgaaggcat gcctaaaagt tacttaccac agactgtacg gcaaggcggc   1020

tacatgcctc ag                                                       1032


<210>  5
<211>  267
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv1

<400>  5

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  6
<211>  803
<212>  DNA
<213>  ˹

<220>  
<223>  CD19 CAR scFv1

<400>  6
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc agc                                            803


<210>  7
<211>  250
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv2

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Gln Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Thr Trp Tyr Gly Gly Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Ala Tyr Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  8
<211>  251
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv3

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Phe Tyr Asp Gly Ser Gln Asn Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Thr Trp Asn Gly Gly Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Pro Ala Gln Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
                165                 170                 175     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Arg Phe Tyr 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  9
<211>  251
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv4

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Thr Trp Asp Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser 
                165                 170                 175     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Ala Tyr 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  10
<211>  251
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv5

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Thr Trp Asn Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser 
                165                 170                 175     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Ala Tyr 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  11
<211>  251
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv6

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Thr Trp Asp Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser 
                165                 170                 175     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Ala Tyr 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  12
<211>  257
<212>  PRT
<213>  ˹

<220>  
<223>  CD19 CAR scFv7

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp His Asp Gly Ser Ile Lys Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Gly Asn Tyr Tyr Gly Trp Gly Ser Tyr Lys Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr 
        115                 120                 125             


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
145                 150                 155                 160 


Leu Ser Val Phe Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Gly Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            180                 185                 190         


Ala Pro Glu Leu Leu Leu Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 
        195                 200                 205             


Pro Ser Arg Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
    210                 215                 220                 


Leu Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Val Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys 
    


<210>  13
<211>  242
<212>  PRT
<213>  ˹

<220>  
<223>  GPC3 CAR scFv

<400>  13

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu 
145                 150                 155                 160 


Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile Gly 
                165                 170                 175     


Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ala 
        


<210>  14
<211>  726
<212>  DNA
<213>  ˹

<220>  
<223>  GPC3 CAR scFv

<400>  14
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc     60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg    120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt    180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc    240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaaatac acatgttcct    300

cctacgttcg gatcggggac caagctggaa ataaaaggtg gaggcggttc aggcggaggt    360

ggcagcggcg gtggcgggtc gcaggttcaa ctgcagcagt ctggggctga gctggtgagg    420

cctggggctt cagtgaagct gtcctgcaag gcttcgggct acacatttac tgactatgaa    480

atgcactggg tgaagcagac acctgtgcat ggcctaaaat ggattggagc tcttgatcct    540

aaaactggtg atactgccta cagtcagaag ttcaagggca aggccacact gactgcagac    600

aaatcctcca gcacagccta catggagctc cgcagcctga catctgagga ctctgccgtc    660

tattactgta caagattcta ctcctatact tactggggcc aagggactct ggtcactgtc    720

tctgca                                                               726


<210>  15
<211>  244
<212>  PRT
<213>  ˹

<220>  
<223>  MUC1 CAR scFv

<400>  15

Asp Ile Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Glu 
            100                 105                 110         


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr 
    210                 215                 220                 


Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  16
<211>  732
<212>  DNA
<213>  ˹

<220>  
<223>  MUC1 CAR scFv

<400>  16
gatatcgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc     60

acttgtcgct caagtactgg ggctgttaca acaagtaact atgccaactg ggtccaagaa    120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc accaggtgtt    180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca    240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc    300

ggtggaggaa ccaaactgac tgtcctagga tccgagggtg gctcaggatc gggtggatca    360

ggctctggtg gctcaggatc ggaggtccag ctgcagcagt caggaggagg cttggtgcaa    420

cctggaggat ccatgaaact ctcctgtgtt gcctctggat tcactttcag taactactgg    480

atgaactggg tccgccagtc tccagagaag gggcttgagt gggttgctga aattagattg    540

aaatctaata attatgcaac acattatgcg gagtctgtga aagggaggtt caccatctca    600

agagatgatt ccaaaagtag tgtctacctg caaatgaaca acttaagagc tgaagacact    660

ggcatttatt actgtacctt tggtaactcc tttgcttact ggggccaagg gaccacggtc    720

accgtctcct ca                                                        732


<210>  17
<211>  267
<212>  PRT
<213>  ˹

<220>  
<223>  Mesothelin scFv

<400>  17

Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser 
1               5                   10                  15      


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser 
            20                  25                  30          


Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
        35                  40                  45              


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr 
    50                  55                  60                  


Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
145                 150                 155                 160 


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
                165                 170                 175     


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
            180                 185                 190         


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
    210                 215                 220                 


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
                245                 250                 255     


Thr Val Leu Ser Gly Ile Leu Glu Gln Gln Gly 
            260                 265         


<210>  18
<211>  801
<212>  DNA
<213>  ˹

<220>  
<223>  Mesothelin scFv

<400>  18
agccaggtac agctgcagca gtcaggtcca ggactcgtga cgccctcgca gaccctctca     60

ctcacctgtg ccatctccgg ggacagtgtc tctagcaaca gtgctacttg gaactggatc    120

aggcagtccc catcgagagg ccttgagtgg ctgggaagga catactacag gtccaagtgg    180

tataacgact atgcagtatc tgtgaaaagt cgaatgagca tcaacccaga cacatccaag    240

aaccagttct ccctgcagct gaactctgtg actcccgagg acacggctgt gtattactgt    300

gcaagaggaa tgatgactta ctattacggt atggacgtct ggggccaagg gaccacggtc    360

accgtctcct caggaattct aggatccggt ggcggtggca gcggcggtgg tggttccgga    420

ggcggcggtt ctcagcctgt gctgactcag tcgtcttccc tctctgcatc tcctggagca    480

tcagccagtc tcacctgcac cttgcgcagt ggcatcaatg ttggtcccta caggatatac    540

tggtaccagc agaagccagg gagtcctccc cagtatctcc tgaactacaa atcagactca    600

gataagcagc agggctctgg agtccccagc cgcttctctg gatccaaaga tgcttcggcc    660

aatgcagggg ttttactcat ctctgggctc cggtctgagg atgaggctga ctattactgt    720

atgatttggc acagcagcgc tgctgtgttc ggaggaggca cccaactgac cgtcctctcc    780

ggaattctag aacaacaggg t                                              801


<210>  19
<211>  250
<212>  PRT
<213>  ˹

<220>  
<223>  PSCA scFv

<400>  19

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp 
                165                 170                 175     


Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly 
    210                 215                 220                 


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250 


<210>  20
<211>  750
<212>  DNA
<213>  ˹

<220>  
<223>  PSCA scFv

<400>  20
gacattcagc tgacccaatc tccaagctct ttgtccgcct ctgtggggga tagggtcacc     60

atcacctgca gtgccagttc aagtgtaaga ttcattcact ggtaccagca gaaaccagga    120

aaagctccca aaagactcat ctatgacaca tccaaactgg cttctggcgt cccttctagg    180

ttcagtggct ccgggtctgg gacagacttc accctcacca ttagcagtct gcagccggaa    240

gatttcgcca cctattactg tcagcagtgg agtagtagcc cattcacgtt cggacagggg    300

accaaggtgg agataaaagg cagtactagc ggcggtggct ccggaggcgg ctccggaggt    360

ggcggcagct cagaggttca gctggtggag tctgggggtg gccttgtgca gccagggggc    420

tcactccgtt tgtcctgcgc agcttctggc ttcaacatta aagactacta tatacactgg    480

gtgcgtcagg cccctggtaa gggcctggaa tgggttgcat ggattgatcc tgagaatggt    540

gacactgaat ttgtcccgaa gttccagggc cgtgccacta taagcgcaga cacatccaaa    600

aacacagcct acctgcagat gaacagcctg cgtgctgagg acactgccgt ctattattgt    660

aaaacggggg ggttctgggg tcaaggaacc ctggtcaccg tctcgagcga gcccaaatct    720

tgtgacaaaa ctcacacatg cccaccgtgc                                     750


<210>  21
<211>  229
<212>  PRT
<213>  ˹

<220>  
<223>  HER2 scFv

<400>  21

Ile Leu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ile Met Ser Ala 
1               5                   10                  15      


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            20                  25                  30          


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
        35                  40                  45              


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
65                  70                  75                  80  


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
                85                  90                  95      


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Gly Gly Ser 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Pro Gly Leu 
        115                 120                 125             


Ala Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
    130                 135                 140                 


Ser Leu Thr Ser Tyr Val Ile Ser Trp Val Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr 
                165                 170                 175     


Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys 
            180                 185                 190         


Ser Gln Val Ser Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
        195                 200                 205             


Arg Tyr Tyr Cys Ala Ser Leu Ser Tyr Asp Gly Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Val 
225                 


<210>  22
<211>  689
<212>  DNA
<213>  ˹

<220>  
<223>  HER2 scFv

<400>  22
attctgatga cccagtctcc agcaatcatg tctgcaatca tgtctgcatc tccaggggag     60

aaggtcacca tgacctgcag tgccagctca agtgtaagtt acatgcactg gtaccagcag    120

aagtcaggca cctcccccaa aagatggatt tatgacacat ccaaactggc ttctggagtc    180

cctgctcgct tcagtggcag tgggtctggg acctcttact ctctcacaat cagcagcatg    240

gaggctgaag atgctgccac ttattactgc cagcagtgga gtagtaaccc gctcacgttc    300

ggtgctggga ccaagctgga aataaaaggt ggctcaggat cgggtggatc aggctctggt    360

ggctcaggat cgggacctgg cctggcggcg ccctcacaga gcctgtccat cacatgcact    420

gtctctgggt tctcattaac cagctatgtt ataagttggg ttcgccagcc accaggaaag    480

ggtctggagt ggcttggagt aatatggact ggtggaggca caaattataa ttcagctctc    540

aaatccagac tgagcatcag caaagacaac tccaagagtc aagtttcctt aaaaatgaac    600

agtctgcaaa ctgatgacac agccaggtac tactgtgcca gcctttccta tgatggtttc    660

gactactggg gccaagggac cacggtcac                                      689


<210>  23
<211>  159
<212>  PRT
<213>  ˹

<220>  
<223>  TLR2

<400>  23

Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr 
1               5                   10                  15      


Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn 
            20                  25                  30          


Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys 
        35                  40                  45              


Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile 
    50                  55                  60                  


Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu 
65                  70                  75                  80  


Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His 
                85                  90                  95      


Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu 
            100                 105                 110         


Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg 
        115                 120                 125             


Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala 
    130                 135                 140                 


Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
145                 150                 155                 


<210>  24
<211>  477
<212>  DNA
<213>  ˹

<220>  
<223>  TLR2

<400>  24
caggccaaaa ggaagcccag gaaagctccc agcaggaaca tctgctatga tgcatttgtt     60

tcttacagtg agcgggatgc ctactgggtg gagaacctta tggtccagga gctggagaac    120

ttcaatcccc ccttcaagtt gtgtcttcat aagcgggact tcattcctgg caagtggatc    180

attgacaata tcattgactc cattgaaaag agccacaaaa ctgtctttgt gctttctgaa    240

aactttgtga agagtgagtg gtgcaagtat gaactggact tctcccattt ccgtcttttt    300

gatgagaaca atgatgctgc cattctcatt cttctggagc ccattgagaa aaaagccatt    360

ccccagcgct tctgcaagct gcggaagata atgaacacca agacctacct ggagtggccc    420

atggacgagg ctcagcggga aggattttgg gtaaatctga gagctgcgat aaagtcc       477


<210>  25
<211>  42
<212>  PRT
<213>  ˹

<220>  
<223>  4-1BB

<400>  25

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  26
<211>  126
<212>  DNA
<213>  ˹

<220>  
<223>  4-1BB

<400>  26
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt    120

gaactg                                                               126


<210>  27
<211>  107
<212>  PRT
<213>  ˹

<220>  
<223>  CD28

<400>  27

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  ˹

<220>  
<223>  CD28

<400>  28
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt    120

tgggtgctgg tggtggttgg gggagtcctg gcttgctata gcttgctagt aacagtggcc    180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac    240

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc    300

gacttcgcag cctatcgctc c                                              321


<210>  29
<211>  162
<212>  PRT
<213>  ˹

<220>  
<223>  TLR1

<400>  29

Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
1               5                   10                  15      


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
            20                  25                  30          


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
        35                  40                  45              


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
    50                  55                  60                  


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
65                  70                  75                  80  


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
                85                  90                  95      


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
            100                 105                 110         


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
        115                 120                 125             


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
    130                 135                 140                 


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
145                 150                 155                 160 


Lys Lys 
        


<210>  30
<211>  486
<212>  DNA
<213>  ˹

<220>  
<223>  TLR1

<400>  30
aacataccct tagaagaact ccaaagaaat ctccagtttc atgcatttat ttcatatagt     60

gggcacgatt ctttctgggt gaagaatgaa ttattgccaa acctagagaa agaaggtatg    120

cagatttgcc ttcatgagag aaactttgtt cctggcaaga gcattgtgga aaatatcatc    180

acctgcattg agaagagtta caagtccatc tttgttttgt ctcccaactt tgtccagagt    240

gaatggtgcc attatgaact ctactttgcc catcacaatc tctttcatga aggatctaat    300

agcttaatcc tgatcttgct ggaacccatt ccgcagtact ccattcctag cagttatcac    360

aagctcaaaa gtctcatggc caggaggact tatttggaat ggcccaagga aaagagcaaa    420

cgtggccttt tttgggctaa cttaagggca gccattaata ttaagctgac agagcaagca    480

aagaaa                                                               486


<210>  31
<211>  24
<212>  PRT
<213>  ˹

<220>  
<223>  DAP10

<400>  31

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  32
<211>  72
<212>  DNA
<213>  ˹

<220>  
<223>  DAP10

<400>  32
ctgtgcgcac gcccacgccg cagccccgcc caagaagatg gcaaagtcta catcaacatg     60

ccaggcaggg gc                                                         72


<210>  33
<211>  64
<212>  DNA
<213>  ˹

<220>  
<223>  ź

<400>  33
aaacatggag acagacacac tcctgctatg ggtgctgctg ctctgggttc caggttccac     60

cggt                                                                  64


<210>  34
<211>  81
<212>  DNA
<213>  ˹

<220>  
<223>  Ĥ

<400>  34
ttttgggtgc tggtggtggt tgggggagtc ctggcttgct atagcttgct agtaacagtg     60

gcctttatta ttttctgggt g                                               81


<210>  35
<211>  336
<212>  DNA
<213>  ˹

<220>  
<223>  CD3

<400>  35
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc    300

tacgacgccc ttcacatgca ggccctgccc cctcgc                              336


<210>  36
<211>  5995
<212>  DNA
<213>  ˹

<220>  
<223>  PB

<400>  36
tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     60

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg    120

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg    180

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct cgactagagc    240

ttgcggaacc cttactcgag ataacttcgt ataatgtatg ctatacgaag ttatgctagc    300

caacaagctc gtcatcgctt tgcagaagag cagagaggat atgctcatcg tctaaagaac    360

tacccatttt attatatatt agtcacgata tctataacaa gaaaatatat atataataag    420

ttatcacgta agtagaacat gaaataacaa tataattatc gtatgagtta aatcttaaaa    480

gtcacgtaaa agataatcat gcgtcatttt gactcacgcg gtcgttatag ttcaaaatca    540

gtgacactta ccgcattgac aagcacgcct cacgggagct ccaagcggcg actgagatgt    600

cctaaatgca cagcgacgga ttcgcgctat ttagaaagag agagcaatat ttcaagaatg    660

catgcgtcaa ttttacgcag actatctttc tagggttaaa aaagatttgc gctttactcg    720

acctaaactt taaacacgtc atagaatctt cgtttgacaa aaaccacatt gtggccaagc    780

tgtgtgacgc gacgcgcgct aaagaatggc aaaccaagtc gcgcgaggta cccagctttt    840

gttcccttta gtgagggtta attccgagct tggcgtaatc atggtcatag ctgtttcctg    900

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta    960

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg   1020

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga   1080

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg   1140

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag   1200

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc   1260

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca   1320

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt   1380

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc   1440

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc   1500

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc   1560

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact   1620

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg   1680

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta   1740

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca   1800

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa   1860

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg   1920

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc   1980

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg   2040

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat   2100

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg   2160

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa   2220

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca   2280

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc   2340

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt   2400

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa   2460

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat   2520

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct   2580

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga   2640

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag   2700

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga   2760

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca   2820

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg   2880

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc   2940

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag   3000

gggttccgcg cacatttccc cgaaaagtgc cacctgggaa attgtaaacg ttaatatttt   3060

gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat   3120

cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt   3180

ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt   3240

ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag   3300

gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg   3360

aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc   3420

gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc   3480

gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg aagggcgatc   3540

ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt   3600

aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt   3660

gtaatacgac tcactatagg gcgaattgga gctcggtatt cacgacagca ggctgaataa   3720

taaaaaaatt agaaactatt atttaaccct agaaagataa tcatattgtg acgtacgtta   3780

aagataatca tgcgtaaaat tgacgcatgt gttttatcgg tctgtatatc gaggtttatt   3840

tattaatttg aatagatatt aagttttatt atatttacac ttacatacta ataataaatt   3900

caacaaacaa tttatttatg tttatttatt tattaaaaaa aaacaaaaac tcaaaatttc   3960

ttctataaag taacaaaact tttaaacatt ctctctttta caaaaataaa cttattttgt   4020

actttaaaaa cagtcatgtt gtattataaa ataagtaatt agcttaacct atacataata   4080

gaaacaaatt atacttatta gtcagtcaga aacaactttg gcacatatca atattatgct   4140

ctcgttaatc gcataacttc gtataatgta tgctatacga agttataatt cagatctttc   4200

ggcgcgccgg gtcgacattg attattgact agttattaat agtaatcaat tacggggtca   4260

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct   4320

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta   4380

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac   4440

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt   4500

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag   4560

tacatctacg tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt   4620

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt   4680

attttgtgca gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg   4740

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc   4800

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg   4860

cgcggcgggc gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc   4920

gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc   4980

cttctcctcc gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc   5040

tgcgtgaaag ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg   5100

ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct   5160

gtgagcgctg cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc   5220

ggccgggggc ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg   5280

ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc   5340

cctgcacccc cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc   5400

ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg   5460

cggggcgggg ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc   5520

gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag   5580

agggcgcagg gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc   5640

gcaccccctc tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg   5700

ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg   5760

ccgcaggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt   5820

gtgaccggcg gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag   5880

ctcctgggca acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attc         5934


<210>  37
<211>  30
<212>  DNA
<213>  ˹

<220>  
<223>  NFAT

<400>  37
ggaggaaaaa ctgtttcata cagaaggcgt                                      30


<210>  38
<211>  105
<212>  DNA
<213>  ˹

<220>  
<223>  IL2

<400>  38
agatctagac tctagagggt atataatgga agctcgaatt ccagcttggc attccggtac     60

tgttggtaaa aagcttggca atccggtact gttggtaaag ccacc                    105


<210>  39
<211>  81
<212>  DNA
<213>  ˹

<220>  
<223>  2A

<400>  39
aaaattgtcg ctcctgtcaa acaaactctt aactttgatt tactcaaact ggctggggat     60

gtagaaagca atccaggtcc a                                               81


<210>  40
<211>  720
<212>  DNA
<213>  ˹

<220>  
<223>  GFP

<400>  40
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac    120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc    180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag    240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc    300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg    360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac    420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac    480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc    540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac    600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc    660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa    720


<210>  41
<211>  4254
<212>  DNA
<213>  ˹

<220>  
<223>  PB-TRE

<400>  41
gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     60

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag    120

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag    180

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct    240

atggcttctg aggcggaaag aaccagctgg ggctcgacta gagcttgcgg aacccttact    300

cgagataact tcgtataatg tatgctatac gaagttatgc tagccaacaa gctcgtcatc    360

gctttgcaga agagcagaga ggatatgctc atcgtctaaa gaactaccca ttttattata    420

tattagtcac gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga    480

acatgaaata acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa    540

tcatgcgtca ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat    600

tgacaagcac gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga    660

cggattcgcg ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac    720

gcagactatc tttctagggt taaaaaagat ttgcgcttta ctcgacctaa actttaaaca    780

cgtcatagaa tcttcgtttg acaaaaacca cattgtggcc aagctgtgtg acgcgacgcg    840

cgctaaagaa tggcaaacca agtcgcgcga ggtacccagc ttttgttccc tttagtgagg    900

gttaattccg agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc    960

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta   1020

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   1080

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   1140

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg   1200

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc   1260

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt   1320

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag   1380

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc   1440

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc   1500

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt   1560

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt   1620

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc   1680

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa   1740

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa   1800

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg   1860

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga   1920

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg   1980

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg   2040

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt   2100

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact   2160

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat   2220

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg   2280

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg   2340

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat   2400

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc   2460

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt   2520

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc   2580

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga   2640

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc   2700

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa   2760

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta   2820

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg   2880

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg   2940

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat   3000

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt   3060

tccccgaaaa gtgccacctg ggaaattgta aacgttaata ttttgttaaa attcgcgtta   3120

aatttttgtt aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat   3180

aaatcaaaag aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca   3240

ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc   3300

ccactacgtg aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta   3360

aatcggaacc ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg   3420

gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg   3480

gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcg   3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg   3600

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca   3660

gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgtaata cgactcacta   3720

tagggcgaat tggagctcgg tattcacgac agcaggctga ataataaaaa aattagaaac   3780

tattatttaa ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta   3840

aaattgacgc atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga   3900

tattaagttt tattatattt acacttacat actaataata aattcaacaa acaatttatt   3960

tatgtttatt tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa   4020

aacttttaaa cattctctct tttacaaaaa taaacttatt ttgtacttta aaaacagtca   4080

tgttgtatta taaaataagt aattagctta acctatacat aatagaaaca aattatactt   4140

attagtcagt cagaaacaac tttggcacat atcaatatta tgctctcgtt aatcgcataa   4200

cttcgtataa tgtatgctat acgaagttat aattcagatc tttcggcgcg ccgg         4254


<210>  42
<211>  2497
<212>  DNA
<213>  ˹

<220>  
<223>  PB-CAG-rtTA

<400>  42
agctttgcaa agatggataa agttttaaac agagaggaat ctttgcagct aatggacctt     60

ctaggtcttg aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc    120

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag    180

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg    240

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt    300

tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg    360

ttatggccct tgcgtgcctt gaattacttc cactggctgc agtacgtgat tcttgatccc    420

gagcttcggg ttggaagtgg gtgggagagt tcgaggcctt gcgcttaagg agccccttcg    480

cctcgtgctt gagttgaggc ctggcctggg cgctggggcc gccgcgtgcg aatctggtgg    540

caccttcgcg cctgtctcgc tgctttcgat aagtctctag ccatttaaaa tttttgatga    600

cctgctgcga cgcttttttt ctggcaagat agtcttgtaa atgcgggcca agatctgcac    660

actggtattt cggtttttgg ggccgcgggc ggcgacgggg cccgtgcgtc ccagcgcaca    720

tgttcggcga ggcggggcct gcgagcgcgg ccaccgagaa tcggacgggg gtagtctcaa    780

gctggccggc ctgctctggt gcctggcctc gcgccgccgt gtatcgcccc gccctgggcg    840

gcaaggctgg cccggtcggc accagttgcg tgagcggaaa gatggccgct tcccggccct    900

gctgcaggga gctcaaaatg gaggacgcgg cgctcgggag agcgggcggg tgagtcaccc    960

acacaaagga aaagggcctt tccgtcctca gccgtcgctt catgtgactc cacggagtac   1020

cgggcgccgt ccaggcacct cgattagttc tcgagctttt ggagtacgtc gtctttaggt   1080

tggggggagg ggttttatgc gatggagttt ccccacactg agtgggtgga gactgaagtt   1140

aggccagctt ggcacttgat gtaattctcc ttggaatttg ccctttttga gtttggatct   1200

tggttcattc tcaagcctca gacagtggtt caaagttttt ttcttccatt tcaggtgtcg   1260

tgaggaattt cgacatttaa atttaattaa tctcgacggt atcggttaac ttttaaaaga   1320

aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac   1380

atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaattttcc gatcacgaga   1440

ctagcctcga ggtttaaact acgggatccg gccattacgg ccgaattcca ccatgtctag   1500

attagataaa agtaaagtga ttaacagcgc attagagctg cttaatgagg tcggaatcga   1560

aggtttaaca acccgtaaac tcgcccagaa gcttggtgta gagcagccta cactgtattg   1620

gcatgtaaaa aataagcggg ctttgctcga cgccttagcc attgagatgt tagataggca   1680

ccatactcac ttttgccctt taaaagggga aagctggcaa gattttttac gcaataacgc   1740

taaaagtttt agatgtgctt tactaagtca tcgcaatgga gcaaaagtac attcagatac   1800

acggcctaca gaaaaacagt atgaaactct cgaaaatcaa ttagcctttt tatgccaaca   1860

aggtttttca ctagagaacg cgttatatgc actcagcgct gtggggcatt ttactttagg   1920

ttgcgtattg gaagatcaag agcatcaagt cgctaaagaa gaaagggaaa cacctactac   1980

tgatagtatg ccgccattat tacgacaagc tatcgaatta tttgatcacc aaggtgcaga   2040

gccagccttc ttattcggcc ttgaattgat catatgcgga ttagaaaaac aacttaaatg   2100

tgaaagtggg tccgcgtaca gccgcgcgcg tacgaaaaac aattacgggt ctaccatcga   2160

gggcctgctc gatctcccgg acgacgacgc ccccgaagag gcggggctgg cggctccgcg   2220

cctgtccttt ctccccgcgg gacacacgcg cagactgtcg acggcccccc cgaccgatgt   2280

cagcctgggg gacgagctcc acttagacgg cgaggacgtg gcgatggcgc atgccgacgc   2340

gctagacgat ttcgatctgg acatgttggg ggacggggat tccccgggtc cgggatttac   2400

cccccacgac tccgccccct acggcgctct ggatatggcc gacttcgagt ttgagcagat   2460

gtttaccgat gcccttggaa ttgacgagta cggtggg                            2497


<210>  43
<211>  2053
<212>  DNA
<213>  ˹

<220>  
<223>  PB-PL623

<400>  43
agagacggcc gcatcttctt gtgcagtgcc agcctcgtcc cgtagacaaa cctgcaggat     60

gggcagcagc ctggacgacg agcacatcct gagcgccctg ctgcagagcg acgacgagct    120

ggtcggcgag gacagcgaca gcgaggtgag cgaccacgtg agcgaggacg acgtgcagtc    180

cgacaccgag gaggccttca tcgacgaggt gcacgaggtg cagcctacca gcagcggctc    240

cgagatcctg gacgagcaga acgtgatcga gcagcccggc agctccctgg ccagcaacag    300

gatcctgacc ctgccccaga ggaccatcag gggcaagaac aagcactgct ggtccacctc    360

caagcccacc aggcggagca gggtgtccgc cctgaacatc gtgagaagcc agaggggccc    420

caccaggatg tgcaggaaca tctacgaccc cctgctgtgc ttcaagctgt tcttcaccga    480

cgagatcatc agcgagatcg tgaagtggac caacgccgag atcagcctga agaggcggga    540

gagcatgacc tccgccacct tcagggacac caacgaggac gagatctacg ccttcttcgg    600

catcctggtg atgaccgccg tgaggaagga caaccacatg agcaccgacg acctgttcga    660

cagatccctg agcatggtgt acgtgagcgt gatgagcagg gacagattcg acttcctgat    720

cagatgcctg aggatggacg acaagagcat caggcccacc ctgcgggaga acgacgtgtt    780

cacccccgtg agaaagatct gggacctgtt catccaccag tgcatccaga actacacccc    840

tggcgcccac ctgaccatcg acgagcagct gctgggcttc aggggcaggt gccccttcag    900

ggtctatatc cccaacaagc ccagcaagta cggcatcaag atcctgatga tgtgcgacag    960

cggcaccaag tacatgatca acggcatgcc ctacctgggc aggggcaccc agaccaacgg   1020

cgtgcccctg ggcgagtact acgtgaagga gctgtccaag cccgtccacg gcagctgcag   1080

aaacatcacc tgcgacaact ggttcaccag catccccctg gccaagaacc tgctgcagga   1140

gccctacaag ctgaccatcg tgggcaccgt gagaagcaac aagagagaga tccccgaggt   1200

cctgaagaac agcaggtcca ggcccgtggg caccagcatg ttctgcttcg acggccccct   1260

gaccctggtg tcctacaagc ccaagcccgc caagatggtg tacctgctgt ccagctgcga   1320

cgaggacgcc agcatcaacg agagcaccgg caagccccag atggtgatgt actacaacca   1380

gaccaagggc ggcgtggaca ccctggacca gatgtgcagc gtgatgacct gcagcagaaa   1440

gaccaacagg tggcccatgg ccctgctgta cggcatgatc aacatcgcct gcatcaacag   1500

cttcatcatc tacagccaca acgtgagcag caagggcgag aaggtgcaga gccggaaaaa   1560

gttcatgcgg aacctgtaca tgggcctgac ctccagcttc atgaggaaga ggctggaggc   1620

ccccaccctg aagagatacc tgagggacaa catcagcaac atcctgccca aagaggtgcc   1680

cggcaccagc gacgacagca ccgaggagcc cgtgatgaag aagaggacct actgcaccta   1740

ctgtcccagc aagatcagaa gaaaggccag cgccagctgc aagaagtgta agaaggtcat   1800

ctgccgggag cacaacatcg acatgtgcca gagctgtttc tgattaatta agaaaccctg   1860

gaccacccac cccagcaagg acactgagca agagaggccc tatcccaact cggcccccaa   1920

cactgagcat ctccctcaca atttccatcc cagaccccca taataacagg aggggcctag   1980

ggagccctcc ctactctctt gaataccatc aataaagttc gctgcaccca caaaaaaaaa   2040

aaaaaaaaaa aaa                                                      2053


<210>  44
<211>  9601
<212>  DNA
<213>  ˹

<220>  
<223>  pWPXLd

<400>  44
gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     60

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc    120

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag    180

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc    240

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc    300

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg    360

ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccatggctg    420

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc    480

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt    540

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcatcggtac    600

gtatggccag gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt    660

tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct    720

ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta    780

actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg    840

tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg    900

gaaaatctct agcagcatct agaattaatt ccgtgtattc tatagtgtca cctaaatcgt    960

atgtgtatga tacataaggt tatgtattaa ttgtagccgc gttctaacga caatatgtac   1020

aagcctaatt gtgtagcatc tggcttactg aagcagaccc tatcatctct ctcgtaaact   1080

gccgtcagag tcggtttggt tggacgaacc ttctgagttt ctggtaacgc cgtcccgcac   1140

ccggaaatgg tcagcgaacc aatcagcagg gtcatcgcta gccagatcct ctacgccgga   1200

cgcatcgtgg ccggcatcac cggcgccaca ggtgcggttg ctggcgccta tatcgccgac   1260

atcaccgatg gggaagatcg ggctcgccac ttcgggctca tgagcgcttg tttcggcgtg   1320

ggtatggtgg caggccccgt ggccggggga ctgttgggcg ccatctcctt gcatgcacca   1380

ttccttgcgg cggcggtgct caacggcctc aacctactac tgggctgctt cctaatgcag   1440

gagtcgcata agggagagcg tcgaatggtg cactctcagt acaatctgct ctgatgccgc   1500

atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   1560

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   1620

gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt   1680

ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa   1740

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat   1800

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca   1860

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca   1920

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta   1980

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt   2040

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc   2100

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc   2160

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc   2220

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa   2280

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga   2340

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat   2400

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca   2460

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc   2520

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat   2580

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag   2640

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa   2700

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca   2760

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc   2820

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc   2880

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc   2940

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt   3000

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt   3060

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc   3120

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa   3180

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac   3240

ctacaccgaa ctgagatacc tacagcgtga gcattgagaa agcgccacgc ttcccgaagg   3300

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga   3360

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact   3420

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa   3480

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc   3540

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg   3600

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat   3660

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctgtg gaatgtgtgt   3720

cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat   3780

ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg   3840

caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg   3900

cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt   3960

tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt   4020

tttggaggcc taggcttttg caaaaagctt ggacacaaga caggcttgcg agatatgttt   4080

gagaatacca ctttatcccg cgtcagggag aggcagtgcg taaaaagacg cggactcatg   4140

tgaaatactg gtttttagtg cgccagatct ctataatctc gcgcaaccta ttttcccctc   4200

gaacactttt taagccgtag ataaacaggc tgggacactt cacatgagcg aaaaatacat   4260

cgtcacctgg gacatgttgc agatccatgc acgtaaactc gcaagccgac tgatgccttc   4320

tgaacaatgg aaaggcatta ttgccgtaag ccgtggcggt ctgtaccggg tgcgttactg   4380

gcgcgtgaac tgggtattcg tcatgtcgat accgtttgta tttccagcta cgatcacgac   4440

aaccagcgcg agcttaaagt gctgaaacgc gcagaaggcg atggcgaagg cttcatcgtt   4500

attgatgacc tggtggatac cggtggtact gcggttgcga ttcgtgaaat gtatccaaaa   4560

gcgcactttg tcaccatctt cgcaaaaccg gctggtcgtc cgctggttga tgactatgtt   4620

gttgatatcc cgcaagatac ctggattgaa cagccgtggg atatgggcgt cgtattcgtc   4680

ccgccaatct ccggtcgcta atcttttcaa cgcctggcac tgccgggcgt tgttcttttt   4740

aacttcaggc gggttacaat agtttccagt aagtattctg gaggctgcat ccatgacaca   4800

ggcaaacctg agcgaaaccc tgttcaaacc ccgctttaaa catcctgaaa cctcgacgct   4860

agtccgccgc tttaatcacg gcgcacaacc gcctgtgcag tcggcccttg atggtaaaac   4920

catccctcac tggtatcgca tgattaaccg tctgatgtgg atctggcgcg gcattgaccc   4980

acgcgaaatc ctcgacgtcc aggcacgtat tgtgatgagc gatgccgaac gtaccgacga   5040

tgatttatac gatacggtga ttggctaccg tggcggcaac tggatttatg agtgggcccc   5100

ggatctttgt gaaggaacct tacttctgtg gtgtgacata attggacaaa ctacctacag   5160

agatttaaag ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga   5220

ttctaattgt ttgtgtattt tagattccaa cctatggaac tgatgaatgg gagcagtggt   5280

ggaatgcctt taatgaggaa aacctgtttt gctcagaaga aatgccatct agtgatgatg   5340

aggctactgc tgactctcaa cattctactc ctccaaaaaa gaagagaaag gtagaagacc   5400

ccaaggactt tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa   5460

ctcttgcttg ctttgctatt tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa   5520

ttatggaaaa atattctgta acctttataa gtaggcataa cagttataat cataacatac   5580

tgttttttct tactccacac aggcatagag tgtctgctat taataactat gctcaaaaat   5640

tgtgtacctt tagcttttta atttgtaaag gggttaataa ggaatatttg atgtatagtg   5700

ccttgactag agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa   5760

aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac   5820

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat   5880

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat   5940

catgtctgga tcaactggat aactcaagct aaccaaaatc atcccaaact tcccacccca   6000

taccctatta ccactgccaa ttacctagtg gtttcattta ctctaaacct gtgattcctc   6060

tgaattattt tcattttaaa gaaattgtat ttgttaaata tgtactacaa acttagtagt   6120

tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca   6180

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac   6240

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca   6300

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg   6360

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag   6420

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg   6480

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat   6540

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga   6600

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct   6660

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc   6720

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag   6780

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg   6840

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga   6900

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg   6960

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg   7020

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct   7080

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat   7140

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca   7200

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc   7260

aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa   7320

ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag   7380

agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc   7440

ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga   7500

caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa   7560

cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct   7620

gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc   7680

atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt   7740

tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata   7800

cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa   7860

ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata   7920

aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt   7980

tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca   8040

accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga gagagacaga   8100

gacagatcca ttcgattagt gaacggatct cgacggtatc gatgtcgacg ataagctttg   8160

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc   8220

ttgaaaggag tgggaattgg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca   8280

gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc   8340

ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga   8400

gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc   8460

agaacacagg taagtgccgt gtgtggttcc cgcgggcctg gcctctttac gggttatggc   8520

ccttgcgtgc cttgaattac ttccactggc tgcagtacgt gattcttgat cccgagcttc   8580

gggttggaag tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg   8640

cttgagttga ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc   8700

gcgcctgtct cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg   8760

cgacgctttt tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta   8820

tttcggtttt tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg   8880

cgaggcgggg cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc   8940

ggcctgctct ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc   9000

tggcccggtc ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag   9060

ggagctcaaa atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa   9120

ggaaaagggc ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc   9180

cgtccaggca cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg   9240

aggggtttta tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag   9300

cttggcactt gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca   9360

ttctcaagcc tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgaggaa   9420

tttcgacatt taaatttaat taatctcgac ggtatcggtt aacttttaaa agaaaagggg   9480

ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa   9540

ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tccgatcacg agactagcct   9600

c                                                                   9601


<210>  45
<211>  3591
<212>  DNA
<213>  ˹

<220>  
<223>  PB

<400>  45
gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga acatgaaata     60

acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa tcatgcgtca    120

ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat tgacaagcac    180

gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga cggattcgcg    240

ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac gcagactatc    300

tttctagggt taaaaaagat ttgcgcttta ctcgacctaa actttaaaca cgtcatagaa    360

tcttcgtttg acaaaaacca cattgtggcc aagctgtgtg acgcgacgcg cgctaaagaa    420

tggcaaacca agtcgcgcga ggtacccagc ttttgttccc tttagtgagg gttaattccg    480

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt    540

ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc    600

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc    660

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct    720

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca    780

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac    840

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt    900

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg    960

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc   1020

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc   1080

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc   1140

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac   1200

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt   1260

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct   1320

aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc   1380

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt   1440

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg   1500

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc   1560

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa   1620

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag   1680

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg   1740

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga   1800

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag   1860

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa   1920

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc   1980

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca   2040

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg   2100

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat   2160

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc   2220

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg   2280

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg   2340

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt   2400

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca   2460

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata   2520

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac   2580

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa   2640

gtgccacctg ggaaattgta aacgttaata ttttgttaaa attcgcgtta aatttttgtt   2700

aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag   2760

aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga   2820

acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg   2880

aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc   2940

ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg   3000

aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc   3060

gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcg cgccattcgc   3120

cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc   3180

agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc   3240

agtcacgacg ttgtaaaacg acggccagtg aattgtaata cgactcacta tagggcgaat   3300

tggagctcgg tattcacgac agcaggctga ataataaaaa aattagaaac tattatttaa   3360

ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc   3420

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt   3480

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt   3540

tatttattaa aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa a            3591
