                         SEQUENCE LISTING

<110>  Kbenhavns Universitet
       Statens Serum Institut
       Singh, Susheel Kumar
       Theisen, Michael
 
<120>  Multivalent malaria transmission-blocking vaccines

<130>  64150PC01

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  148
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 Pro domain protein sequence
<222>  (1)..(1)

<400>  1

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu 
145             


<210>  2
<211>  444
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 Pro domain nucleic acid sequence
<222>  (1)..(1)

<400>  2
gaatatgtcg acgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacttat gaaaaatctg aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg aagcaaagtt      180

cttcttgacg acgatacaat tagccgtgtc tcaaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc agttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aattgattta      360

agttatgaaa caacagaatc aggggacaca gctgtttctg aagattcata tgataaatat      420

gcttcaaata atacaaataa agaa                                             444


<210>  3
<211>  146
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain I protein sequence
<222>  (1)..(1)

<400>  3

Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr Glu Ser Gly Pro 
1               5                   10                  15      


Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro Leu Ile Lys Val 
            20                  25                  30          


Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys Leu Tyr Asp Asn 
        35                  40                  45              


Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val Leu Thr Lys Glu 
    50                  55                  60                  


Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu Ile Tyr Gly Leu 
65                  70                  75                  80  


Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn Phe Lys Glu Gly 
                85                  90                  95      


Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys Ala Thr Val Phe 
            100                 105                 110         


Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp Asn Lys Lys Gly 
        115                 120                 125             


Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr Gly Asn Lys Ile 
    130                 135                 140                 


Asn Gly 
145     


<210>  4
<211>  438
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain I nucleic acid sequence
<222>  (1)..(1)

<400>  4
tacgtttgtg attttacaga tcaattaaaa ccaacagaaa gtggtcctaa agtaaaaaaa       60

tgtgaagtaa aagttaatga gccattaata aaagtaaaaa taatatgtcc attaaaaggt      120

tctgtagaaa aattatatga taatatagaa tatgtaccta aaaaaagccc atatgttgtt      180

ttaacaaaag aggaaactaa actaaaggaa aaacttctct cgaaacttat ttatggttta      240

ttaatatctc cgacggttaa cgaaaaggag aataatttta aagaaggtgt tattgaattt      300

actcttcccc ctgtggtaca caaggcaaca gtgttttatt ttatatgtga taattcaaaa      360

acagaagatg ataacaaaaa aggaaataga gggattgtag aagtgtatgt agaaccatat      420

ggtaataaaa ttaatgga                                                    438


<210>  5
<211>  182
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain II protein sequence
<222>  (1)..(1)

<400>  5

Cys Ala Phe Leu Asp Glu Asp Glu Glu Glu Glu Lys Tyr Gly Asn Gln 
1               5                   10                  15      


Ile Glu Glu Asp Glu His Asn Glu Lys Ile Lys Met Lys Thr Phe Phe 
            20                  25                  30          


Thr Gln Asn Ile Tyr Lys Lys Asn Asn Ile Tyr Pro Cys Tyr Met Lys 
        35                  40                  45              


Leu Tyr Ser Gly Asp Ile Gly Gly Ile Leu Phe Pro Lys Asn Ile Lys 
    50                  55                  60                  


Ser Thr Thr Cys Phe Glu Glu Met Ile Pro Tyr Asn Lys Glu Ile Lys 
65                  70                  75                  80  


Trp Asn Lys Glu Asn Lys Ser Leu Gly Asn Leu Val Asn Asn Ser Val 
                85                  90                  95      


Val Tyr Asn Lys Glu Met Asn Ala Lys Tyr Phe Asn Val Gln Tyr Val 
            100                 105                 110         


His Ile Pro Thr Ser Tyr Lys Asp Thr Leu Asn Leu Phe Cys Ser Ile 
        115                 120                 125             


Ile Leu Lys Glu Glu Glu Ser Asn Leu Ile Ser Thr Ser Tyr Leu Val 
    130                 135                 140                 


Tyr Val Ser Ile Asn Glu Glu Leu Asn Phe Ser Leu Phe Asp Phe Tyr 
145                 150                 155                 160 


Glu Ser Phe Val Pro Ile Lys Lys Thr Ile Gln Val Ala Gln Lys Asn 
                165                 170                 175     


Val Asn Asn Lys Glu His 
            180         


<210>  6
<211>  546
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain II nucleic acid sequence
<222>  (1)..(1)

<400>  6
tgtgctttct tggatgaaga tgaagaagaa gaaaaatatg gtaatcaaat tgaagaagat       60

gaacataatg agaagataaa aatgaaaaca ttctttaccc agaatatata taaaaaaaat      120

aatatatatc catgttatat gaaattatat agcggagata taggtggtat tctatttcct      180

aagaatataa aatcaacaac gtgttttgaa gagatgatac cttataataa agaaataaaa      240

tggaataaag aaaataaaag tttaggtaac ttagttaata attctgtagt atataataaa      300

gagatgaatg caaaatattt taatgttcag tatgttcaca ttcctacaag ttataaagat      360

acattaaatt tattttgtag tattatatta aaagaagagg aaagtaattt aatttctact      420

tcttatttag tatatgtaag tattaatgaa gaattaaatt tttcactttt cgatttttat      480

gaatcatttg tacctataaa aaaaaccata caagtagctc aaaagaatgt aaataataaa      540

gaacat                                                                 546


<210>  7
<211>  214
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain III protein sequence
<222>  (1)..(1)

<400>  7

Asp Tyr Thr Cys Asp Phe Thr Asp Lys Leu Asp Lys Thr Val Pro Ser 
1               5                   10                  15      


Thr Ala Asn Gly Lys Lys Leu Phe Ile Cys Arg Lys His Leu Lys Glu 
            20                  25                  30          


Phe Asp Thr Phe Thr Leu Lys Cys Asn Val Asn Lys Thr Gln Tyr Pro 
        35                  40                  45              


Asn Ile Glu Ile Phe Pro Lys Thr Leu Lys Asp Lys Lys Glu Val Leu 
    50                  55                  60                  


Lys Leu Asp Leu Asp Ile Gln Tyr Gln Met Phe Ser Lys Phe Phe Lys 
65                  70                  75                  80  


Phe Asn Thr Gln Asn Ala Lys Tyr Leu Asn Leu Tyr Pro Tyr Tyr Leu 
                85                  90                  95      


Ile Phe Pro Phe Asn His Ile Gly Lys Lys Glu Leu Lys Asn Asn Pro 
            100                 105                 110         


Thr Tyr Lys Asn His Lys Asp Val Lys Tyr Phe Glu Gln Ser Ser Val 
        115                 120                 125             


Leu Ser Pro Leu Ser Ser Ala Asp Ser Leu Gly Lys Leu Leu Asn Phe 
    130                 135                 140                 


Leu Asp Thr Gln Glu Thr Val Cys Leu Thr Glu Lys Ile Arg Tyr Leu 
145                 150                 155                 160 


Asn Leu Ser Ile Asn Glu Leu Gly Ser Asp Asn Asn Thr Phe Ser Val 
                165                 170                 175     


Thr Phe Gln Val Pro Pro Tyr Ile Asp Ile Lys Glu Pro Phe Tyr Phe 
            180                 185                 190         


Met Phe Gly Cys Asn Asn Asn Lys Gly Glu Gly Asn Ile Gly Ile Val 
        195                 200                 205             


Glu Leu Leu Ile Ser Lys 
    210                 


<210>  8
<211>  645
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 domain III nucleic acid sequence
<222>  (1)..(1)

<400>  8
gattatacat gtgattttac cgataaatta gataaaacgg ttccttctac tgctaatggg       60

aagaaattat ttatatgtag aaagcattta aaagaatttg atacatttac cttaaaatgt      120

aatgttaata aaacacaata tccaaatatc gagatatttc ctaaaacatt aaaagataaa      180

aaggaagtat taaaattaga tcttgatata caatatcaaa tgtttagtaa attttttaaa      240

ttcaatacac agaatgcaaa gtatttaaat ttatatccat attatttaat ttttccattt      300

aatcatatag gaaaaaaaga attaaaaaat aatcctacat ataaaaatca taaagatgtg      360

aaatattttg agcaatcatc tgtattatct cccttatctt ccgcagacag tttagggaaa      420

ttattaaatt ttttagatac tcaagagacg gtatgtctta cggaaaagat aagatattta      480

aatttaagta tcaatgagtt aggatctgat aataatacat tttctgtaac atttcaggtt      540

ccaccatata tagatattaa ggaacctttt tattttatgt ttggttgtaa taataataaa      600

ggtgaaggga atatcggaat tgttgaatta ttaatatcta agcaa                      645


<210>  9
<211>  296
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 Pro+I protein sequence
<222>  (1)..(1)

<400>  9

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Arg Ser Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys 
145                 150                 155                 160 


Pro Thr Glu Ser Gly Pro Lys Val Lys Lys Cys Glu Val Lys Val Asn 
                165                 170                 175     


Glu Pro Leu Ile Lys Val Lys Ile Ile Cys Pro Leu Lys Gly Ser Val 
            180                 185                 190         


Glu Lys Leu Tyr Asp Asn Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr 
        195                 200                 205             


Val Val Leu Thr Lys Glu Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser 
    210                 215                 220                 


Lys Leu Ile Tyr Gly Leu Leu Ile Ser Pro Thr Val Asn Glu Lys Glu 
225                 230                 235                 240 


Asn Asn Phe Lys Glu Gly Val Ile Glu Phe Thr Leu Pro Pro Val Val 
                245                 250                 255     


His Lys Ala Thr Val Phe Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu 
            260                 265                 270         


Asp Asp Asn Lys Lys Gly Asn Arg Gly Ile Val Glu Val Tyr Val Glu 
        275                 280                 285             


Pro Tyr Gly Asn Lys Ile Asn Gly 
    290                 295     


<210>  10
<211>  888
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230 Pro+I nucleic acid sequence
<222>  (1)..(1)

<400>  10
gaatatgtcg acgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacttat gaaaaatctg aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg aagcaaagtt      180

cttcttgacg acgatacaat tagccgtgtc tcaaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc agttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aattgattta      360

agttatgaaa caacagaatc aggggacaca gctgtttctg aagattcata tgataaatat      420

gcttcaaata atacaaataa agaaagatcc tacgtttgtg attttacaga tcaattaaaa      480

ccaacagaaa gtggtcctaa agtaaaaaaa tgtgaagtaa aagttaatga gccattaata      540

aaagtaaaaa taatatgtcc attaaaaggt tctgtagaaa aattatatga taatatagaa      600

tatgtaccta aaaaaagccc atatgttgtt ttaacaaaag aggaaactaa actaaaggaa      660

aaacttctct cgaaacttat ttatggttta ttaatatctc cgacggttaa cgaaaaggag      720

aataatttta aagaaggtgt tattgaattt actcttcccc ctgtggtaca caaggcaaca      780

gtgttttatt ttatatgtga taattcaaaa acagaagatg ataacaaaaa aggaaataga      840

gggattgtag aagtgtatgt agaaccatat ggtaataaaa ttaatgga                   888


<210>  11
<211>  138
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs48/45 6C domain protein sequence
<222>  (1)..(1)

<400>  11

Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser 
1               5                   10                  15      


Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser 
            20                  25                  30          


Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His 
        35                  40                  45              


Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe 
    50                  55                  60                  


Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val 
65                  70                  75                  80  


Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp 
                85                  90                  95      


Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile Val Gly Ser Ile 
            100                 105                 110         


Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser 
        115                 120                 125             


Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
    130                 135             


<210>  12
<211>  414
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs48/45 6C domain nucleic acid sequence
<222>  (1)..(1)

<400>  12
gaaaaaaaag tcatacacgg atgtaacttc tcttcaaatg ttagttctaa acatactttt       60

acagatagtt tagatatttc tttagttgat gatagtgcac atatttcatg taacgtacat      120

ttgtctgaac caaaatataa tcatttggta ggtttaaatt gtcctggtga tattatacca      180

gattgctttt ttcaagtata tcaacctgaa tcagaagaac ttgaaccatc caacattgtt      240

tatttagatt cacaaataaa tataggagat attgaatatt atgaagatgc tgaaggagat      300

gataaaatta aattatttgg tatagttgga agtataccaa aaacgacatc ttttacttgt      360

atatgtaaga aggataaaaa aagtgcttat atgacagtta ctatagattc agca            414


<210>  13
<211>  270
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs48/45 10C domain protein sequence
<222>  (1)..(1)

<400>  13

Asp Asn Thr Glu Lys Val Ile Ser Ser Ile Glu Gly Arg Ser Ala Met 
1               5                   10                  15      


Val His Val Arg Val Leu Lys Tyr Pro His Asn Ile Leu Phe Thr Asn 
            20                  25                  30          


Leu Thr Asn Asp Leu Phe Thr Tyr Leu Pro Lys Thr Tyr Asn Glu Ser 
        35                  40                  45              


Asn Phe Val Ser Asn Val Leu Glu Val Glu Leu Asn Asp Gly Glu Leu 
    50                  55                  60                  


Phe Val Leu Ala Cys Glu Leu Ile Asn Lys Lys Cys Phe Gln Glu Gly 
65                  70                  75                  80  


Lys Glu Lys Ala Leu Tyr Lys Ser Asn Lys Ile Ile Tyr His Lys Asn 
                85                  90                  95      


Leu Thr Ile Phe Lys Ala Pro Phe Tyr Val Thr Ser Lys Asp Val Asn 
            100                 105                 110         


Thr Glu Cys Thr Cys Lys Phe Lys Asn Asn Asn Tyr Lys Ile Val Leu 
        115                 120                 125             


Lys Pro Lys Tyr Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser 
    130                 135                 140                 


Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu 
145                 150                 155                 160 


Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro 
                165                 170                 175     


Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro 
            180                 185                 190         


Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro 
        195                 200                 205             


Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu 
    210                 215                 220                 


Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile 
225                 230                 235                 240 


Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys 
                245                 250                 255     


Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
            260                 265                 270 


<210>  14
<211>  810
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs 48/45 10C domain nucleic acid sequence
<222>  (1)..(1)

<400>  14
gataatactg aaaaggttat atcaagtata gaagggagaa gtgctatggt acatgtacgt       60

gtattaaaat atccacataa tattttattt actaatttaa caaatgatct ttttacatat      120

ttgccgaaaa catataatga atctaatttt gtaagtaatg tattagaagt agaattgaat      180

gatggagaat tatttgtttt agcttgtgaa ctaattaata aaaaatgttt tcaagaagga      240

aaagaaaaag ccttatataa aagtaataaa ataatttatc ataaaaactt aactatcttt      300

aaagctccat tttatgttac atcaaaagat gttaatacag aatgtacatg caaatttaaa      360

aataataatt ataaaatagt tttaaaacca aaatatgaaa aaaaagtcat acacggatgt      420

aacttctctt caaatgttag ttctaaacat acttttacag atagtttaga tatttcttta      480

gttgatgata gtgcacatat ttcatgtaac gtacatttgt ctgaaccaaa atataatcat      540

ttggtaggtt taaattgtcc tggtgatatt ataccagatt gcttttttca agtatatcaa      600

cctgaatcag aagaacttga accatccaac attgtttatt tagattcaca aataaatata      660

ggagatattg aatattatga agatgctgaa ggagatgata aaattaaatt atttggtata      720

gttggaagta taccaaaaac gacatctttt acttgtatat gtaagaagga taaaaaaagt      780

gcttatatga cagttactat agattcagca                                       810


<210>  15
<211>  288
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230-Pfs48/45 Pro-6C protein sequence
<222>  (1)..(1)

<400>  15

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Arg Ser Glu Lys Lys Val Ile His Gly Cys Asn Phe 
145                 150                 155                 160 


Ser Ser Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile 
                165                 170                 175     


Ser Leu Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser 
            180                 185                 190         


Glu Pro Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile 
        195                 200                 205             


Ile Pro Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu 
    210                 215                 220                 


Glu Pro Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp 
225                 230                 235                 240 


Ile Glu Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe 
                245                 250                 255     


Gly Ile Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys 
            260                 265                 270         


Lys Lys Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
        275                 280                 285             


<210>  16
<211>  864
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230-Pfs48/45 Pro-6C nucleic acid sequence
<222>  (1)..(1)

<400>  16
gaatatgtcg acgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacttat gaaaaatctg aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg aagcaaagtt      180

cttcttgacg acgatacaat tagccgtgtc tcaaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc agttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aattgattta      360

agttatgaaa caacagaatc aggggacaca gctgtttctg aagattcata tgataaatat      420

gcttcaaata atacaaataa agaaagatcc gaaaaaaaag tcatacacgg atgtaacttc      480

tcttcaaatg ttagttctaa acatactttt acagatagtt tagatatttc tttagttgat      540

gatagtgcac atatttcatg taacgtacat ttgtctgaac caaaatataa tcatttggta      600

ggtttaaatt gtcctggtga tattatacca gattgctttt ttcaagtata tcaacctgaa      660

tcagaagaac ttgaaccatc caacattgtt tatttagatt cacaaataaa tataggagat      720

attgaatatt atgaagatgc tgaaggagat gataaaatta aattatttgg tatagttgga      780

agtataccaa aaacgacatc ttttacttgt atatgtaaga aggataaaaa aagtgcttat      840

atgacagtta ctatagattc agca                                             864


<210>  17
<211>  436
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  Pfs230-Pfs48/45 Pro+I-6C protein sequence
<222>  (1)..(1)

<400>  17

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Arg Ser Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys 
145                 150                 155                 160 


Pro Thr Glu Ser Gly Pro Lys Val Lys Lys Cys Glu Val Lys Val Asn 
                165                 170                 175     


Glu Pro Leu Ile Lys Val Lys Ile Ile Cys Pro Leu Lys Gly Ser Val 
            180                 185                 190         


Glu Lys Leu Tyr Asp Asn Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr 
        195                 200                 205             


Val Val Leu Thr Lys Glu Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser 
    210                 215                 220                 


Lys Leu Ile Tyr Gly Leu Leu Ile Ser Pro Thr Val Asn Glu Lys Glu 
225                 230                 235                 240 


Asn Asn Phe Lys Glu Gly Val Ile Glu Phe Thr Leu Pro Pro Val Val 
                245                 250                 255     


His Lys Ala Thr Val Phe Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu 
            260                 265                 270         


Asp Asp Asn Lys Lys Gly Asn Arg Gly Ile Val Glu Val Tyr Val Glu 
        275                 280                 285             


Pro Tyr Gly Asn Lys Ile Asn Gly Arg Ser Glu Lys Lys Val Ile His 
    290                 295                 300                 


Gly Cys Asn Phe Ser Ser Asn Val Ser Ser Lys His Thr Phe Thr Asp 
305                 310                 315                 320 


Ser Leu Asp Ile Ser Leu Val Asp Asp Ser Ala His Ile Ser Cys Asn 
                325                 330                 335     


Val His Leu Ser Glu Pro Lys Tyr Asn His Leu Val Gly Leu Asn Cys 
            340                 345                 350         


Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu 
        355                 360                 365             


Ser Glu Glu Leu Glu Pro Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile 
    370                 375                 380                 


Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys 
385                 390                 395                 400 


Ile Lys Leu Phe Gly Ile Val Gly Ser Ile Pro Lys Thr Thr Ser Phe 
                405                 410                 415     


Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser Ala Tyr Met Thr Val Thr 
            420                 425                 430         


Ile Asp Ser Ala 
        435     


<210>  18
<211>  1308
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  Pfs230-Pfs48/45 Pro+I-6C nucleic acid sequence
<222>  (1)..(1)

<400>  18
gaatatgtcg acgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacttat gaaaaatctg aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg aagcaaagtt      180

cttcttgacg acgatacaat tagccgtgtc tcaaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc agttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aattgattta      360

agttatgaaa caacagaatc aggggacaca gctgtttctg aagattcata tgataaatat      420

gcttcaaata atacaaataa agaaagatcc tacgtttgtg attttacaga tcaattaaaa      480

ccaacagaaa gtggtcctaa agtaaaaaaa tgtgaagtaa aagttaatga gccattaata      540

aaagtaaaaa taatatgtcc attaaaaggt tctgtagaaa aattatatga taatatagaa      600

tatgtaccta aaaaaagccc atatgttgtt ttaacaaaag aggaaactaa actaaaggaa      660

aaacttctct cgaaacttat ttatggttta ttaatatctc cgacggttaa cgaaaaggag      720

aataatttta aagaaggtgt tattgaattt actcttcccc ctgtggtaca caaggcaaca      780

gtgttttatt ttatatgtga taattcaaaa acagaagatg ataacaaaaa aggaaataga      840

gggattgtag aagtgtatgt agaaccatat ggtaataaaa ttaatggaag atccgaaaaa      900

aaagtcatac acggatgtaa cttctcttca aatgttagtt ctaaacatac ttttacagat      960

agtttagata tttctttagt tgatgatagt gcacatattt catgtaacgt acatttgtct     1020

gaaccaaaat ataatcattt ggtaggttta aattgtcctg gtgatattat accagattgc     1080

ttttttcaag tatatcaacc tgaatcagaa gaacttgaac catccaacat tgtttattta     1140

gattcacaaa taaatatagg agatattgaa tattatgaag atgctgaagg agatgataaa     1200

attaaattat ttggtatagt tggaagtata ccaaaaacga catcttttac ttgtatatgt     1260

aagaaggata aaaaaagtgc ttatatgaca gttactatag attcagca                  1308


<210>  19
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SpyCatcher protein sequence


<220>
<221>  SpyCatcher protein sequence
<222>  (1)..(1)

<400>  19

Gly Ala Met Val Asp Thr Leu Ser Gly Leu Ser Ser Glu Gln Gly Gln 
1               5                   10                  15      


Ser Gly Asp Met Thr Ile Glu Glu Asp Ser Ala Thr His Ile Lys Phe 
            20                  25                  30          


Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly 
    50                  55                  60                  


Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu 
65                  70                  75                  80  


Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr 
                85                  90                  95      


Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly 
            100                 105                 110         


Asp Ala His Ile Gly Gly Ser 
        115                 


<210>  20
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SpyCatcher nucleic acid sequence


<220>
<221>  SpyCatcher nucleic acid sequence
<222>  (1)..(1)

<400>  20
ggtgcaatgg ttgataccct gagcggtctg agcagcgaac agggtcagag cggtgatatg       60

accattgaag aagatagcgc aacccacatc aaattcagca aacgtgatga agatggtaaa      120

gaactggcag gcgcaacaat ggaactgcgt gatagcagcg gtaaaaccat tagcacctgg      180

attagtgatg gtcaggtgaa agatttttat ctgtaccctg gcaaatacac ctttgttgaa      240

accgcagcac cggatggtta tgaagttgca accgcaatta cctttaccgt taatgaacag      300

ggccaggtta ccgtgaatgg taaagcaacc aaaggtgatg cacatattgg tggtagc         357


<210>  21
<211>  474
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  GLURP protein sequence
<222>  (1)..(1)

<400>  21

Thr Ser Glu Asn Arg Asn Lys Arg Ile Gly Gly Pro Lys Leu Arg Gly 
1               5                   10                  15      


Asn Val Thr Ser Asn Ile Lys Phe Pro Ser Asp Asn Lys Gly Lys Ile 
            20                  25                  30          


Ile Arg Gly Ser Asn Asp Lys Leu Asn Lys Asn Ser Glu Asp Val Leu 
        35                  40                  45              


Glu Gln Ser Glu Lys Ser Leu Val Ser Glu Asn Val Pro Ser Gly Leu 
    50                  55                  60                  


Asp Ile Asp Asp Ile Pro Lys Glu Ser Ile Phe Ile Gln Glu Asp Gln 
65                  70                  75                  80  


Glu Gly Gln Thr His Ser Glu Leu Asn Pro Glu Thr Ser Glu His Ser 
                85                  90                  95      


Lys Asp Leu Asn Asn Asn Gly Ser Lys Asn Glu Ser Ser Asp Ile Ile 
            100                 105                 110         


Ser Glu Asn Asn Lys Ser Asn Lys Val Gln Asn His Phe Glu Ser Leu 
        115                 120                 125             


Ser Asp Leu Glu Leu Leu Glu Asn Ser Ser Gln Asp Asn Leu Asp Lys 
    130                 135                 140                 


Asp Thr Ile Ser Thr Glu Pro Phe Pro Asn Gln Lys His Lys Asp Leu 
145                 150                 155                 160 


Gln Gln Asp Leu Asn Asp Glu Pro Leu Glu Pro Phe Pro Thr Gln Ile 
                165                 170                 175     


His Lys Asp Tyr Lys Glu Lys Asn Leu Ile Asn Glu Glu Asp Ser Glu 
            180                 185                 190         


Pro Phe Pro Arg Gln Lys His Lys Lys Val Asp Asn His Asn Glu Glu 
        195                 200                 205             


Lys Asn Val Phe His Glu Asn Gly Ser Ala Asn Gly Asn Gln Gly Ser 
    210                 215                 220                 


Leu Lys Leu Lys Ser Phe Asp Glu His Leu Lys Asp Glu Lys Ile Glu 
225                 230                 235                 240 


Asn Glu Pro Leu Val His Glu Asn Leu Ser Ile Pro Asn Asp Pro Ile 
                245                 250                 255     


Glu Gln Ile Leu Asn Gln Pro Glu Gln Glu Thr Asn Ile Gln Glu Gln 
            260                 265                 270         


Leu Tyr Asn Glu Lys Gln Asn Val Glu Glu Lys Gln Asn Ser Gln Ile 
        275                 280                 285             


Pro Ser Leu Asp Leu Lys Glu Pro Thr Asn Glu Asp Ile Leu Pro Asn 
    290                 295                 300                 


His Asn Pro Leu Glu Asn Ile Lys Gln Ser Glu Ser Glu Ile Asn His 
305                 310                 315                 320 


Val Gln Asp His Ala Leu Pro Lys Glu Asn Ile Ile Asp Lys Leu Asp 
                325                 330                 335     


Asn Gln Lys Glu His Ile Asp Gln Ser Gln His Asn Ile Asn Val Leu 
            340                 345                 350         


Gln Glu Asn Asn Ile Asn Asn His Gln Leu Glu Pro Gln Glu Lys Pro 
        355                 360                 365             


Asn Ile Glu Ser Phe Glu Pro Lys Asn Ile Asp Ser Glu Ile Ile Leu 
    370                 375                 380                 


Pro Glu Asn Val Glu Thr Glu Glu Ile Ile Asp Asp Val Pro Ser Pro 
385                 390                 395                 400 


Lys His Ser Asn His Glu Thr Phe Glu Glu Glu Thr Ser Glu Ser Glu 
                405                 410                 415     


His Glu Glu Ala Val Ser Glu Lys Asn Ala His Glu Thr Val Glu His 
            420                 425                 430         


Glu Glu Thr Val Ser Gln Glu Ser Asn Pro Glu Lys Ala Asp Asn Asp 
        435                 440                 445             


Gly Asn Val Ser Gln Asn Ser Asn Asn Glu Leu Asn Glu Asn Glu Phe 
    450                 455                 460                 


Val Glu Ser Glu Lys Ser Glu His Glu Ala 
465                 470                 


<210>  22
<211>  1422
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  GLURP nucleic acid sequence
<222>  (1)..(1)

<400>  22
acaagtgaga atagaaataa acgaatcggg ggtcctaaat taaggggtaa tgttacaagt       60

aatataaagt tcccatcaga taacaaaggt aaaattataa gaggttcgaa tgataaactt      120

aataaaaact ctgaagatgt tttagaacaa agcgaaaaat cgcttgtttc agaaaatgtt      180

cctagtggat tagatataga tgatatccct aaagaatcta tttttattca agaagatcaa      240

gaaggtcaaa ctcattctga attaaatcct gaaacatcag aacatagtaa agatttaaat      300

aataatggtt caaaaaatga atctagtgat attatttcag aaaataataa atcaaataaa      360

gtacaaaatc attttgaatc attatcagat ttagaattac ttgaaaattc ctcacaagat      420

aatttagaca aagatacaat ttcaacagaa ccttttccta atcaaaaaca taaagactta      480

caacaagatt taaatgatga acctttagaa ccctttccta cacaaataca taaagattat      540

aaagaaaaaa atttaataaa tgaagaagat tcagaaccat ttcccagaca aaagcataaa      600

aaggtagaca atcataatga agaaaaaaac gtatttcatg aaaatggttc tgcaaatggt      660

aatcaaggaa gtttgaaact taaatcattc gatgaacatt taaaagatga aaaaatagaa      720

aatgaaccac ttgttcatga aaatttatcc ataccaaatg atccaataga acaaatatta      780

aatcaacctg aacaagaaac aaatatccag gaacaattgt ataatgaaaa acaaaatgtt      840

gaagaaaaac aaaattctca aataccttcg ttagatttaa aagaaccaac aaatgaagat      900

attttaccaa atcataatcc attagaaaat ataaaacaaa gtgaatcaga aataaatcat      960

gtacaagatc atgcgctacc aaaagagaat ataatagaca aacttgataa tcaaaaagaa     1020

cacatcgatc aatcacaaca taatataaat gtattacaag aaaataacat aaacaatcac     1080

caattagaac ctcaagagaa acctaatatt gaatcgtttg aacctaaaaa tatagattca     1140

gaaattattc ttcctgaaaa tgttgaaaca gaagaaataa tagatgatgt gccttcccct     1200

aaacattcta accatgaaac atttgaagaa gaaacaagtg aatctgaaca tgaagaagcc     1260

gtatctgaaa aaaatgccca cgaaactgtc gaacatgaag aaactgtgtc tcaagaaagc     1320

aatcctgaaa aagctgataa tgatggaaat gtatctcaaa acagcaacaa cgaattaaat     1380

gaaaatgaat tcgttgaatc ggaaaaaagc gagcatgaag ca                        1422


<210>  23
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SpyTag protein sequence


<220>
<221>  SpyTag protein sequence
<222>  (1)..(1)

<400>  23

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly Ser 
1               5                   10                  15      


<210>  24
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SpyTag nucleic acid sequence


<220>
<221>  SpyTag nucleic acid sequence
<222>  (1)..(1)

<400>  24
gctcatattg ttatggttga tgcttataaa cctactaaag gtggatca                    48


<210>  25
<211>  222
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  CSP protein sequence
<222>  (1)..(1)

<400>  25

Gly Ser Ser Ser Asn Thr Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn 
1               5                   10                  15      


Ala Gly Thr Asn Leu Tyr Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys 
            20                  25                  30          


Gln Glu Asn Trp Tyr Ser Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu 
        35                  40                  45              


Asn Asp Asp Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys 
    50                  55                  60                  


His Lys Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala 
65                  70                  75                  80  


Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala 
                85                  90                  95      


Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
            100                 105                 110         


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        115                 120                 125             


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    130                 135                 140                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
145                 150                 155                 160 


Asn Pro Asn Ala Asn Pro Asn Lys Asn Asn Gln Gly Asn Gly Gln Gly 
                165                 170                 175     


His Asn Met Pro Asn Asp Pro Asn Arg Asn Val Asp Glu Asn Ala Asn 
            180                 185                 190         


Ala Asn Ser Ala Val Lys Asn Asn Asn Asn Glu Glu Pro Ser Asp Lys 
        195                 200                 205             


His Ile Lys Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser 
    210                 215                 220         


<210>  26
<211>  666
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  CSP nucleic acid sequence
<222>  (1)..(1)

<400>  26
ggttcatcat caaatacccg tgttcttaac gaacttaact atgataatgc cggtacaaat       60

ctttataatg aacttgaaat gaattattac ggtaaacaag aaaattggta ttcattgaaa      120

aaaaactcac gttcacttgg tgaaaatgac gacgggaata atgaagataa tgaaaaactt      180

cgtaaaccaa aacataaaaa acttaaacaa ccagccgacg gaaatccaga tccaaatgct      240

aatccaaatg ttgaccctaa cgccaatcct aatgtagacc caaatgcaaa ccctaacgtt      300

gatcctaatg ctaacccaaa cgccaatcca aacgcaaatc ctaatgccaa tccaaacgct      360

aaccctaacg ctaacccaaa tgctaatcct aatgcaaacc ctaatgcaaa tccaaatgcc      420

aatcctaacg caaatccaaa cgcaaaccca aatgcaaacc ctaatgctaa cccaaatgca      480

aacccaaacg ctaatcctaa caaaaacaat caaggtaatg gtcaagggca caatatgcca      540

aatgatccaa atcgtaatgt tgatgaaaat gccaacgcta actcagccgt taaaaacaac      600

aataacgaag aaccatcaga taaacatatt aaagaatatc ttaacaaaat tcaaaattca      660

ctttca                                                                 666


<210>  27
<211>  172
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  MSP3 protein sequence
<222>  (1)..(1)

<400>  27

Lys Ala Lys Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu Phe 
1               5                   10                  15      


Gly Gly Gly Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser His 
            20                  25                  30          


Leu Tyr Val Ser Ser Lys Asp Lys Glu Asn Ile Ser Lys Glu Asn Asp 
        35                  40                  45              


Asp Val Leu Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu Glu 
    50                  55                  60                  


Glu Leu Glu Glu Lys Asn Glu Glu Glu Thr Glu Ser Glu Ile Ser Glu 
65                  70                  75                  80  


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Asn Asp 
                85                  90                  95      


Lys Lys Lys Glu Gln Glu Lys Glu Gln Ser Asn Glu Asn Asn Asp Gln 
            100                 105                 110         


Lys Lys Asp Met Glu Ala Gln Asn Leu Ile Ser Lys Asn Gln Asn Asn 
        115                 120                 125             


Asn Glu Lys Asn Val Lys Glu Ala Ala Glu Ser Ile Met Lys Thr Leu 
    130                 135                 140                 


Ala Gly Leu Ile Lys Gly Asn Asn Gln Ile Asp Ser Thr Leu Lys Asp 
145                 150                 155                 160 


Leu Val Glu Glu Leu Ser Lys Tyr Phe Lys Asn His 
                165                 170         


<210>  28
<211>  516
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  MSP3 nucleic acid sequence
<222>  (1)..(1)

<400>  28
aaagcaaaag aagcttctag ttatgattat attttaggtt gggaatttgg aggaggcgtt       60

ccagaacaca aaaaagaaga aaatatgtta tcacatttat atgtttcttc aaaggataag      120

gaaaatatat ctaaggaaaa tgatgatgta ttagatgaga aggaagaaga ggcagaagaa      180

acagaagaag aagaacttga agaaaaaaat gaagaagaaa cagaatcaga aataagtgaa      240

gatgaagaag aagaagaaga agaagaagaa aaggaagaag aaaatgacaa aaaaaaagaa      300

caagaaaaag aacaaagtaa tgaaaataat gatcaaaaaa aagatatgga agcacagaat      360

ttaatttcta aaaaccagaa taataatgag aaaaacgtaa aagaagctgc tgaaagcatc      420

atgaaaactt tagctggttt aatcaaggga aataatcaaa tagattctac cttaaaagat      480

ttagtagaag aattatccaa atattttaaa aatcat                                516


<210>  29
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pfs230 Pro domain forward primer


<220>
<221>  Pfs230 Pro domain forward primer
<222>  (1)..(1)

<400>  29

Gly Ala Ala Thr Gly Gly Ala Thr Cys Cys Gly Ala Ala Thr Ala Thr 
1               5                   10                  15      


Gly Thr Cys Gly Ala Cys Gly Ala Ala Ala Ala Ala Gly Ala Ala Cys 
            20                  25                  30          


Gly 
    


<210>  30
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 Pro domain reverse primer


<220>
<221>  Pfs230 Pro domain reverse primer
<222>  (1)..(1)

<400>  30
gaatagatct ttctttattt gtattatttg aagc                                   34


<210>  31
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain I forward primer


<220>
<221>  Pfs230 domain I forward primer
<222>  (1)..(1)

<400>  31
gaatggatcc tacgtttgtg attttacaga tcaattaaaa cc                          42


<210>  32
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain I reverse primer


<220>
<221>  Pfs230 domain I reverse primer
<222>  (1)..(1)

<400>  32
gaatagatct tccattaatt ttattaccat atgg                                   34


<210>  33
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain II forward primer


<220>
<221>  Pfs230 domain II forward primer
<222>  (1)..(1)

<400>  33
gaatggatcc tgtgctttct tggatgaaga tgaagaagaa gaaaaatatg g                51


<210>  34
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain II reverse primer


<220>
<221>  Pfs230 domain II reverse primer
<222>  (1)..(1)

<400>  34
gaatagatct atgttcttta ttatttacat tcttttgagc                             40


<210>  35
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain III forward primer


<220>
<221>  Pfs230 domain III forward primer
<222>  (1)..(1)

<400>  35
gaatagatct gattatacat gtgattttac cgataaatta gataaaacg                   49


<210>  36
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs230 domain III reverse primer


<220>
<221>  Pfs230 domain III reverse primer
<222>  (1)..(1)

<400>  36
gaatggatcc ttgcttagat attaataatt caacaattcc                             40


<210>  37
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs48/45 10C domain forward primer


<220>
<221>  Pfs48/45 10C domain forward primer
<222>  (1)..(1)

<400>  37
caatggatcc gataatactg aaaaggttat atcaagtata gaagg                       45


<210>  38
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs48/45 10C domain reverse primer


<220>
<221>  Pfs48/45 10C domain reverse primer
<222>  (1)..(1)

<400>  38
ccatagatct tgctgaatct atagtaactg tcatataagc                             40


<210>  39
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs48/45 6C domain forward primer


<220>
<221>  Pfs48/45 6C domain forward primer
<222>  (1)..(1)

<400>  39
ccatggatcc gaaaaaaaag tcatacacgg atgtaacttc                             40


<210>  40
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfs48/45 6C domain reverse primer


<220>
<221>  Pfs48/45 6C domain reverse primer
<222>  (1)..(1)

<400>  40
ccatagatct tgctgaatct atagtaactg tcatataagc                             40


<210>  41
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker to SpyTag


<220>
<221>  Linker to SpyTag
<222>  (1)..(1)

<400>  41

Gly Ser Gly Thr Ala Gly Gly Gly Ser Gly Ser 
1               5                   10      


<210>  42
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker Flex2 protein sequence

<400>  42

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  43
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker Flex2 nucleic acid sequence

<400>  43
ggcggaggcg gttcaggtgg tggtggaagc ggaggtggtg gatca                       45


<210>  44
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker CsTSR protein sequence

<400>  44

Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys 
1               5                   10                  15      


Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser 
            20                  25                  30          


Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys 
        35                  40                  45              


Lys Ile Cys Lys Met Glu Lys Cys Ser 
    50                  55          


<210>  45
<211>  171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker CsTSR nucleic acid sequence

<400>  45
tatcttaaca aaattcaaaa ttcactttca acagaatggt caccatgttc agttacatgt       60

ggtaatggta ttcaagttcg tatcaaacca gggtcagcca ataaacctaa agacgaattg      120

gattacgcca atgatattga aaaaaaaatt tgtaaaatgg aaaaatgttc a               171


<210>  46
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker CsLNK protein sequence

<400>  46

Asn Met Pro Asn Asp Pro Asn Arg Asn Val Asp Glu Asn Ala Asn Ala 
1               5                   10                  15      


Asn Ser Ala Val Lys Asn Asn Asn Asn Glu Glu 
            20                  25          


<210>  47
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker CsLNK nucleic acid sequence

<400>  47
aacatgccaa atgatccaaa tcgtaatgtt gacgaaaatg ccaatgctaa ctcagccgtt       60

aaaaacaata acaatgaaga a                                                 81


<210>  48
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker Cs3 protein sequence

<400>  48

Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
1               5                   10                  15      


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            20                  25                  30          


Asn Ala Asn Pro 
        35      


<210>  49
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker Cs3 nucleic acid sequence

<400>  49
aatgctaatc caaatgttga tccaaatgca aatcctaacg tagacccaaa cgcaaaccct       60

aatgtcgatc ctaacgccaa tccaaatgct aaccctaatg ctaatcct                   108


<210>  50
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker Sol protein sequence

<400>  50

Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser Leu Asp 
1               5                   10                  15      


<210>  51
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker Sol nucleic acid sequence

<400>  51
aaagaatcag gttcagtttc atcagaacaa cttgcccaat ttcgtagctt ggac             54


<210>  52
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro(Flex2)-6C protein sequence

<400>  52

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn 
                165                 170                 175     


Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val 
            180                 185                 190         


Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys 
        195                 200                 205             


Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp 
    210                 215                 220                 


Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser 
225                 230                 235                 240 


Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr 
                245                 250                 255     


Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile Val 
            260                 265                 270         


Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp 
        275                 280                 285             


Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
    290                 295                 300     


<210>  53
<211>  903
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro(Flex2)-6C nucleic acid sequence

<400>  53
gaatacgttg atgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacatat gaaaaatcag aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg gtcaaaagtt      180

cttcttgacg acgatacaat ttcacgtgtt agcaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc tgttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aatcgatctt      360

tcatacgaaa caacagaatc aggtgataca gccgtttcag aagattcata cgataaatac      420

gcctcaaata atacaaataa agaaggcgga ggcggttcag gtggtggtgg aagcggaggt      480

ggtggatcag aaaaaaaagt tattcacggg tgtaattttt catctaatgt ttcatcaaaa      540

catactttta cagattcact tgatatttca cttgttgacg actcagccca catttcatgt      600

aatgtccatc ttagcgaacc aaaatacaat caccttgttg ggcttaattg tccaggtgat      660

attattccag actgtttttt tcaagtttac caaccagaat cagaagaatt ggaaccatca      720

aacattgttt atcttgattc acaaatcaat attggtgata ttgaatacta tgaagatgcc      780

gaaggggatg ataaaatcaa actttttggt atcgtcggtt caattccaaa aaccacctca      840

ttcacctgta tttgtaaaaa agacaaaaaa tcagcttata tgacagttac aatcgactca      900

gct                                                                    903


<210>  54
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro(CsTSR)-6C protein sequence

<400>  54

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu 
145                 150                 155                 160 


Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile 
                165                 170                 175     


Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Ala Asn 
            180                 185                 190         


Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Glu Lys Lys 
        195                 200                 205             


Val Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser Lys His Thr 
    210                 215                 220                 


Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser Ala His Ile 
225                 230                 235                 240 


Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His Leu Val Gly 
                245                 250                 255     


Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe Gln Val Tyr 
            260                 265                 270         


Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val Tyr Leu Asp 
        275                 280                 285             


Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp Ala Glu Gly 
    290                 295                 300                 


Asp Asp Lys Ile Lys Leu Phe Gly Ile Val Gly Ser Ile Pro Lys Thr 
305                 310                 315                 320 


Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser Ala Tyr Met 
                325                 330                 335     


Thr Val Thr Ile Asp Ser Ala 
            340             


<210>  55
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro(CsTSR)-6C nucleic acid sequence

<400>  55
gaatacgttg atgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacatat gaaaaatcag aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg gtcaaaagtt      180

cttcttgacg acgatacaat ttcacgtgtt agcaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc tgttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aatcgatctt      360

tcatacgaaa caacagaatc aggtgataca gccgtttcag aagattcata cgataaatac      420

gcctcaaata atacaaataa agaatatctt aacaaaattc aaaattcact ttcaacagaa      480

tggtcaccat gttcagttac atgtggtaat ggtattcaag ttcgtatcaa accagggtca      540

gccaataaac ctaaagacga attggattac gccaatgata ttgaaaaaaa aatttgtaaa      600

atggaaaaat gttcagaaaa aaaagttatt catggttgta atttttcatc taatgtttca      660

tcaaaacata cttttacaga ttcacttgat atttcacttg ttgacgactc agcccacatt      720

tcatgtaatg tccatcttag cgaaccaaaa tacaatcacc ttgttgggct taattgtcca      780

ggtgatatta ttccagactg ttttttccaa gtttatcaac cagaatcaga agaattggaa      840

ccatcaaaca ttgtttatct tgattcacaa atcaatattg gagatattga atactatgaa      900

gatgccgaag gggatgataa aatcaaactt tttggtatcg tcggttcaat tccaaaaacc      960

acctcattca cctgtatttg taaaaaagac aaaaaatcag cttatatgac agttacaatc     1020

gactcagct                                                             1029


<210>  56
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro(CsLNK)-6C protein sequence

<400>  56

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Asn Met Pro Asn Asp Pro Asn Arg Asn Val Asp Glu 
145                 150                 155                 160 


Asn Ala Asn Ala Asn Ser Ala Val Lys Asn Asn Asn Asn Glu Glu Glu 
                165                 170                 175     


Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser Lys 
            180                 185                 190         


His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser Ala 
        195                 200                 205             


His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His Leu 
    210                 215                 220                 


Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe Gln 
225                 230                 235                 240 


Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val Tyr 
                245                 250                 255     


Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp Ala 
            260                 265                 270         


Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile Val Gly Ser Ile Pro 
        275                 280                 285             


Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser Ala 
    290                 295                 300                 


Tyr Met Thr Val Thr Ile Asp Ser Ala 
305                 310             


<210>  57
<211>  939
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro(CsLNK)-6C nucleic acid sequence

<400>  57
gaatacgttg atgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacatat gaaaaatcag aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg gtcaaaagtt      180

cttcttgacg acgatacaat ttcacgtgtt agcaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc tgttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aatcgatctt      360

tcatacgaaa caacagaatc aggtgataca gccgtttcag aagattcata cgataaatac      420

gcctcaaata atacaaataa agaaaacatg ccaaatgatc caaatcgtaa tgttgacgaa      480

aatgccaatg ctaactcagc cgttaaaaac aataacaatg aagaagaaaa aaaagttatt      540

catggttgta atttttcatc taatgtttca tcaaaacata cttttacaga ttcacttgat      600

atttcacttg ttgacgactc agcccacatt tcatgtaatg tccatcttag cgaaccaaaa      660

tacaatcacc ttgttgggct taattgtcca ggtgatatta ttccagactg tttttttcaa      720

gtttaccaac cagaatcaga agaattggaa ccatcaaaca ttgtttatct tgattcacaa      780

atcaatattg gtgatattga atactatgaa gatgccgaag gggatgataa aatcaaactt      840

tttggtatcg tcggttcaat tccaaaaacc acctcattca cctgtatttg taaaaaagac      900

aaaaaatcag cttatatgac agttacaatc gactcagct                             939


<210>  58
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro(Cs3)-6C protein sequence

<400>  58

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro 
145                 150                 155                 160 


Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro 
                165                 170                 175     


Asn Ala Asn Pro Asn Ala Asn Pro Glu Lys Lys Val Ile His Gly Cys 
            180                 185                 190         


Asn Phe Ser Ser Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu 
        195                 200                 205             


Asp Ile Ser Leu Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His 
    210                 215                 220                 


Leu Ser Glu Pro Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly 
225                 230                 235                 240 


Asp Ile Ile Pro Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu 
                245                 250                 255     


Glu Leu Glu Pro Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile 
            260                 265                 270         


Gly Asp Ile Glu Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys 
        275                 280                 285             


Leu Phe Gly Ile Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys 
    290                 295                 300                 


Ile Cys Lys Lys Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp 
305                 310                 315                 320 


Ser Ala 
        


<210>  59
<211>  966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro(Cs3)-6C nucleic acid sequence

<400>  59
gaatacgttg atgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacatat gaaaaatcag aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg gtcaaaagtt      180

cttcttgacg acgatacaat ttcacgtgtt agcaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc tgttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aatcgatctt      360

tcatacgaaa caacagaatc aggtgataca gccgtttcag aagattcata cgataaatac      420

gcctcaaata atacaaataa agaaaatgct aatccaaatg ttgatccaaa tgcaaatcct      480

aacgtagacc caaacgcaaa ccctaatgtc gatcctaacg ccaatccaaa tgctaaccct      540

aatgctaatc ctgaaaaaaa agtcatccac ggttgtaatt tttcatctaa tgtttcatca      600

aaacatactt ttacagattc acttgatatt tcacttgttg acgactcagc ccacatttca      660

tgtaatgtcc atcttagcga accaaaatac aatcaccttg ttgggcttaa ttgtccaggt      720

gatattattc cagactgttt tttccaagtt tatcaaccag aatcagaaga attggaacca      780

tcaaacattg tttatcttga ttcacaaatc aatattggtg atattgaata ctatgaagat      840

gccgaagggg atgataaaat caaacttttt ggtatcgtcg gttcaattcc aaaaaccacc      900

tcattcacct gtatttgtaa aaaagacaaa aaatcagctt atatgacagt tacaatcgac      960

tcagct                                                                 966


<210>  60
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro(Sol)-6C protein sequence

<400>  60

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala 
145                 150                 155                 160 


Gln Phe Arg Ser Leu Asp Glu Lys Lys Val Ile His Gly Cys Asn Phe 
                165                 170                 175     


Ser Ser Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile 
            180                 185                 190         


Ser Leu Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser 
        195                 200                 205             


Glu Pro Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile 
    210                 215                 220                 


Ile Pro Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu 
225                 230                 235                 240 


Glu Pro Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp 
                245                 250                 255     


Ile Glu Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe 
            260                 265                 270         


Gly Ile Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys 
        275                 280                 285             


Lys Lys Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
    290                 295                 300                 


<210>  61
<211>  912
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro(Sol)-6C nucleic acid sequence

<400>  61
gaatacgttg atgaaaaaga acgtcaaggt gaaatttatc cattcggcga cgaagaagaa       60

aaagatgaag gtggtgaaag ctttacatat gaaaaatcag aagttgataa aactgatttg      120

tttaaattca tcgaaggcgg tgaaggtgac gacgtttata aagttgatgg gtcaaaagtt      180

cttcttgacg acgatacaat ttcacgtgtt agcaaaaaac atacagctcg tgatggtgaa      240

tacggtgaat atggggaagc tgttgaagat ggggaaaacg tcattaaaat catccgttca      300

gttcttcaat caggtgcttt accatcagtt ggtgttgatg aacttgacaa aatcgatctt      360

tcatacgaaa caacagaatc aggtgataca gccgtttcag aagattcata cgataaatac      420

gcctcaaata atacaaataa agaaaaagaa tcaggttcag tttcatcaga acaacttgcc      480

caatttcgta gcttggacga aaaaaaagtt atccacgggt gtaatttttc atctaatgtt      540

tcttcaaaac atacttttac agattcactt gatatttcac ttgttgacga ctcagcccac      600

atttcatgta atgtccatct tagcgaacca aaatacaatc accttgttgg gcttaattgt      660

ccaggtgata ttattccaga ctgttttttt caagtttacc aaccagaatc agaagaattg      720

gaaccatcaa acattgttta tcttgattca caaatcaata ttggtgatat tgaatactat      780

gaagatgccg aaggggatga taaaatcaaa ctttttggta tcgtcggttc aattccaaaa      840

accacctcat tcacctgtat ttgtaaaaaa gacaaaaaat cagcttatat gacagttaca      900

atcgactcag ct                                                          912


<210>  62
<211>  284
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  I-6C protein sequence
<222>  (1)..(1)

<400>  62

Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr Glu Ser Gly Pro 
1               5                   10                  15      


Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro Leu Ile Lys Val 
            20                  25                  30          


Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys Leu Tyr Asp Asn 
        35                  40                  45              


Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val Leu Thr Lys Glu 
    50                  55                  60                  


Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu Ile Tyr Gly Leu 
65                  70                  75                  80  


Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn Phe Lys Glu Gly 
                85                  90                  95      


Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys Ala Thr Val Phe 
            100                 105                 110         


Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp Asn Lys Lys Gly 
        115                 120                 125             


Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr Gly Asn Lys Ile 
    130                 135                 140                 


Asn Gly Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn Val 
145                 150                 155                 160 


Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp 
                165                 170                 175     


Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr 
            180                 185                 190         


Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys 
        195                 200                 205             


Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn 
    210                 215                 220                 


Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr 
225                 230                 235                 240 


Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile Val Gly 
                245                 250                 255     


Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys 
            260                 265                 270         


Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
        275                 280                 


<210>  63
<211>  852
<212>  DNA
<213>  Plasmodium falciparum


<220>
<221>  I-6C nucleic acid sequence
<222>  (1)..(1)

<400>  63
tacgtgtgcg atttcaccga tcagctgaag ccaaccgaga gcggccccaa agtgaagaaa       60

tgcgaagtga aagtgaacga gcccctgatc aaagtcaaga tcatctgccc gctgaagggc      120

agcgtggaaa agctgtacga taacatcgag tacgtgccca agaaaagccc ctacgtggtg      180

ctgaccaaag aggaaacgaa gctgaaagag aagctgctga gcaagctgat ctacggcctg      240

ctgatctccc cgaccgtgaa cgagaaagag aacaacttca aagagggcgt catcgagttc      300

accctgccgc cagtggtgca taaggccacc gtgttctact tcatctgcga taacagcaag      360

accgaggacg acaacaagaa gggcaaccgc ggcatcgtgg aagtgtacgt ggaaccctac      420

ggcaacaaga tcaacggcga gaagaaagtg atccacggct gcaacttcag cagcaacgtg      480

tccagcaagc acaccttcac cgatagcctg gatatcagcc tggtggatga tagcgcccac      540

atctcctgca atgtgcacct gagcgagccc aagtacaatc acctcgtggg actgaactgc      600

ccaggcgata tcatccccga ttgctttttc caagtgtacc agccagagag cgaggaactg      660

gaacccagca acatcgtgta cctggatagc cagatcaaca tcggcgatat cgagtactac      720

gaggatgccg agggcgacga taagatcaag ctgttcggca ttgtgggcag catccccaag      780

accaccagct ttacctgcat ctgcaagaag gacaagaaat ccgcctacat gaccgtgacc      840

atcgatagtg cc                                                          852


<210>  64
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I-CSpep-6C protein sequence

<400>  64

Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr Glu Ser Gly Pro 
1               5                   10                  15      


Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro Leu Ile Lys Val 
            20                  25                  30          


Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys Leu Tyr Asp Asn 
        35                  40                  45              


Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val Leu Thr Lys Glu 
    50                  55                  60                  


Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu Ile Tyr Gly Leu 
65                  70                  75                  80  


Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn Phe Lys Glu Gly 
                85                  90                  95      


Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys Ala Thr Val Phe 
            100                 105                 110         


Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp Asn Lys Lys Gly 
        115                 120                 125             


Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr Gly Asn Lys Ile 
    130                 135                 140                 


Asn Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys 
145                 150                 155                 160 


Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro 
                165                 170                 175     


Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Glu Lys Lys Val 
            180                 185                 190         


Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser Lys His Thr Phe 
        195                 200                 205             


Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser Ala His Ile Ser 
    210                 215                 220                 


Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His Leu Val Gly Leu 
225                 230                 235                 240 


Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe Gln Val Tyr Gln 
                245                 250                 255     


Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val Tyr Leu Asp Ser 
            260                 265                 270         


Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp Ala Glu Gly Asp 
        275                 280                 285             


Asp Lys Ile Lys Leu Phe Gly Ile Val Gly Ser Ile Pro Lys Thr Thr 
    290                 295                 300                 


Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser Ala Tyr Met Thr 
305                 310                 315                 320 


Val Thr Ile Asp Ser Ala 
                325     


<210>  65
<211>  978
<212>  DNA
<213>  Artificial sequence

<220>
<223>  I-CSpep-6C nucleic acid sequence

<400>  65
tacgtgtgcg atttcaccga tcagctgaag ccaaccgaga gcggccccaa agtgaagaaa       60

tgcgaagtga aagtgaacga gcccctgatc aaagtcaaga tcatctgccc gctgaagggc      120

agcgtggaaa agctgtacga taacatcgag tacgtgccca agaaaagccc ctacgtggtg      180

ctgaccaaag aggaaacgaa gctgaaagag aagctgctga gcaagctgat ctacggcctg      240

ctgatctccc cgaccgtgaa cgagaaagag aacaacttca aagagggcgt catcgagttc      300

accctgccgc cagtggtgca taaggccacc gtgttctact tcatctgcga taacagcaag      360

accgaggacg acaacaagaa gggcaaccgc ggcatcgtgg aagtgtacgt ggaaccctac      420

ggcaacaaga tcaatggcaa caacgaggac aacgaaaagc tgcgcaagcc caagcacaag      480

aagctgaagc agccagccga tggcaacccc gatccgaacg ccaatccaaa cgtggacccc      540

aatgctaacc ccaatgtgga ccccgagaag aaagtgatcc acggctgcaa cttcagcagc      600

aacgtgtcca gcaagcacac cttcaccgat agcctggata tcagcctggt ggatgatagc      660

gcccacatct cctgcaatgt gcacctgagc gagcccaagt acaatcacct cgtgggactg      720

aactgcccag gcgatatcat ccccgattgc tttttccaag tgtaccagcc agagagcgag      780

gaactggaac ccagcaacat cgtgtacctg gatagccaga tcaacatcgg cgatatcgag      840

tactacgagg atgccgaggg cgacgataag atcaagctgt tcggcattgt gggcagcatc      900

cccaagacca ccagctttac ctgcatctgc aagaaggaca agaaatccgc ctacatgacc      960

gtgaccatcg atagtgcc                                                    978


<210>  66
<211>  606
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-10C protein sequence

<400>  66

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr 
145                 150                 155                 160 


Glu Ser Gly Pro Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro 
                165                 170                 175     


Leu Ile Lys Val Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys 
            180                 185                 190         


Leu Tyr Asp Asn Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val 
        195                 200                 205             


Leu Thr Lys Glu Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu 
    210                 215                 220                 


Ile Tyr Gly Leu Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn 
225                 230                 235                 240 


Phe Lys Glu Gly Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys 
                245                 250                 255     


Ala Thr Val Phe Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp 
            260                 265                 270         


Asn Lys Lys Gly Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr 
        275                 280                 285             


Gly Asn Lys Ile Asn Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys 
    290                 295                 300                 


Pro Lys His Lys Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro 
305                 310                 315                 320 


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
                325                 330                 335     


Asp Asn Thr Glu Lys Val Ile Ser Ser Ile Glu Gly Arg Ser Ala Met 
            340                 345                 350         


Val His Val Arg Val Leu Lys Tyr Pro His Asn Ile Leu Phe Thr Asn 
        355                 360                 365             


Leu Thr Asn Asp Leu Phe Thr Tyr Leu Pro Lys Thr Tyr Asn Glu Ser 
    370                 375                 380                 


Asn Phe Val Ser Asn Val Leu Glu Val Glu Leu Asn Asp Gly Glu Leu 
385                 390                 395                 400 


Phe Val Leu Ala Cys Glu Leu Ile Asn Lys Lys Cys Phe Gln Glu Gly 
                405                 410                 415     


Lys Glu Lys Ala Leu Tyr Lys Ser Asn Lys Ile Ile Tyr His Lys Asn 
            420                 425                 430         


Leu Thr Ile Phe Lys Ala Pro Phe Tyr Val Thr Ser Lys Asp Val Asn 
        435                 440                 445             


Thr Glu Cys Thr Cys Lys Phe Lys Asn Asn Asn Tyr Lys Ile Val Leu 
    450                 455                 460                 


Lys Pro Lys Tyr Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser 
465                 470                 475                 480 


Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu 
                485                 490                 495     


Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro 
            500                 505                 510         


Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro 
        515                 520                 525             


Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro 
    530                 535                 540                 


Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu 
545                 550                 555                 560 


Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile 
                565                 570                 575     


Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys 
            580                 585                 590         


Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
        595                 600                 605     


<210>  67
<211>  1818
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-10C nucleic acid sequence

<400>  67
gagtacgtgg acgagaaaga gcgccagggc gagatctacc ccttcggaga tgaggaagaa       60

aaggacgaag gcggcgagag cttcacctac gagaagtccg aagtggataa gaccgacctg      120

ttcaagttca tcgaaggcgg agagggcgac gatgtgtaca aggtggacgg aagcaaggtg      180

ctgctggatg atgataccat cagccgcgtg tccaagaagc acacagctcg cgacggcgag      240

tacggcgaat atggcgaagc tgtggaagat ggcgagaacg tgatcaagat catccgcagc      300

gtgctgcaaa gcggagcctt gccaagtgtg ggagtcgatg agctggacaa gatcgacctg      360

agctacgaga caaccgagag cggagataca gccgtgtccg aggatagcta cgataagtac      420

gccagcaaca acaccaacaa agagtacgtc tgcgatttca ccgatcagct gaagcccacc      480

gagtcgggcc ccaaagtgaa gaaatgcgaa gtgaaagtga acgagcccct gatcaaagtg      540

aaaatcatct gcccgctgaa gggcagcgtg gaaaagctgt acgataacat tgagtacgtg      600

cccaagaaaa gcccctacgt ggtgctgacc aaagaggaaa cgaagctgaa agagaagctg      660

ctgagcaagc tgatctacgg cctgctgatc tccccgaccg tgaatgagaa agagaacaac      720

ttcaaagagg gcgtcatcga gttcaccctg ccgccagtgg tgcataaggc caccgtgttc      780

tacttcatct gcgataacag caagaccgag gacgacaaca agaagggcaa ccgcggcatc      840

gtggaagtgt acgtggaacc ctacggcaac aagatcaatg gcaacaacga ggacaacgaa      900

aagctgcgca agcccaagca caagaagctg aagcagccag ccgatggcaa ccccgatccg      960

aacgccaatc caaacgtgga ccccaatgct aaccccaatg tggaccccga taacaccgag     1020

aaagtgatct ccagcattga gggccgcagt gccatggtgc atgtgcgcgt gctgaagtac     1080

ccgcacaaca tcctgttcac caacctgacc aacgatctgt tcacctatct gcccaagacc     1140

tacaacgaga gcaacttcgt gtccaacgtg ctggaagtgg aactgaacga tggcgagctg     1200

tttgtgctgg cctgcgagct gattaacaag aagtgcttcc aagagggcaa agagaaggcc     1260

ctgtacaagt ccaacaagat tatctaccac aagaacctga cgatcttcaa ggccccgttc     1320

tacgtgacca gcaaggatgt gaataccgag tgcacatgca agttcaagaa caacaactac     1380

aagatcgtgc tcaagccgaa gtacgagaag aaagtcatcc acggctgcaa cttcagcagc     1440

aacgtgtcct ccaagcacac cttcaccgat agcctggata tcagcctggt ggatgatagc     1500

gcccacatct cctgcaatgt gcacctgagc gagcccaagt acaatcacct cgtgggactg     1560

aactgcccag gcgatatcat ccccgattgc tttttccaag tgtaccagcc agagagcgag     1620

gaactggaac ccagcaacat cgtgtacctg gatagccaga tcaacatcgg cgatatcgag     1680

tactacgagg atgccgaagg cgacgataag atcaagctgt tcggcattgt gggcagcatc     1740

cccaagacca ccagctttac ctgcatctgc aagaaggaca agaaatccgc ctacatgacc     1800

gtgaccatcg atagtgcc                                                   1818


<210>  68
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-6C protein sequence

<400>  68

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr 
145                 150                 155                 160 


Glu Ser Gly Pro Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro 
                165                 170                 175     


Leu Ile Lys Val Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys 
            180                 185                 190         


Leu Tyr Asp Asn Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val 
        195                 200                 205             


Leu Thr Lys Glu Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu 
    210                 215                 220                 


Ile Tyr Gly Leu Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn 
225                 230                 235                 240 


Phe Lys Glu Gly Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys 
                245                 250                 255     


Ala Thr Val Phe Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp 
            260                 265                 270         


Asn Lys Lys Gly Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr 
        275                 280                 285             


Gly Asn Lys Ile Asn Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys 
    290                 295                 300                 


Pro Lys His Lys Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro 
305                 310                 315                 320 


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
                325                 330                 335     


Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser 
            340                 345                 350         


Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser 
        355                 360                 365             


Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His 
    370                 375                 380                 


Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe 
385                 390                 395                 400 


Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val 
                405                 410                 415     


Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp 
            420                 425                 430         


Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile Val Gly Ser Ile 
        435                 440                 445             


Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser 
    450                 455                 460                 


Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
465                 470                 


<210>  69
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-6C nucleic acid sequence

<400>  69
gaattcgcca ccatgaagct gtgcatcctg ctggccgtgg tggcctttgt tggactgagt       60

ttgggagagt acgtggacga gaaagagcgc cagggcgaga tctacccctt cggagatgag      120

gaagaaaagg acgaaggcgg cgagagcttc acctacgaga agtccgaagt ggataagacc      180

gacctgttca agttcatcga aggcggagag ggcgacgatg tgtacaaggt ggacggaagc      240

aaggtgctgc tggatgatga taccatcagc cgcgtgtcca agaagcacac agctcgcgac      300

ggcgagtacg gcgaatatgg cgaagctgtg gaagatggcg agaacgtgat caagatcatc      360

cgcagcgtgc tgcaaagcgg agccttgcca agtgtgggag tcgatgagct ggacaagatc      420

gacctgagct acgagacaac cgagagcgga gatacagccg tgtccgagga tagctacgat      480

aagtacgcca gcaacaacac caacaaagag tacgtctgcg atttcaccga tcagctgaag      540

cccaccgagt cgggccccaa agtgaagaaa tgcgaagtga aagtgaacga gcccctgatc      600

aaagtgaaaa tcatctgccc gctgaagggc agcgtggaaa agctgtacga taacattgag      660

tacgtgccca agaaaagccc ctacgtggtg ctgaccaaag aggaaacgaa gctgaaagag      720

aagctgctga gcaagctgat ctacggcctg ctgatctccc cgaccgtgaa tgagaaagag      780

aacaacttca aagagggcgt catcgagttc accctgccgc cagtggtgca taaggccacc      840

gtgttctact tcatctgcga taacagcaag accgaggacg acaacaagaa gggcaaccgc      900

ggcatcgtgg aagtgtacgt ggaaccctac ggcaacaaga tcaatggcaa caacgaggac      960

aacgaaaagc tgcgcaagcc caagcacaag aagctgaagc agccagccga tggcaacccc     1020

gatccgaacg ccaatccaaa cgtggacccc aatgctaacc ccaatgtgga ccccgagaag     1080

aaagtgatcc acggctgcaa cttcagcagc aacgtgtcct ccaagcacac cttcaccgat     1140

agcctggata tcagcctggt ggatgatagc gcccacatct cctgcaatgt gcacctgagc     1200

gagcccaagt acaatcacct cgtgggactg aactgcccag gcgatatcat ccccgattgc     1260

tttttccaag tgtaccagcc agagagcgag gaactggaac ccagcaacat cgtgtacctg     1320

gatagccaga tcaacatcgg cgatatcgag tactacgagg atgccgaagg cgacgataag     1380

atcaagctgt tcggcattgt gggcagcatc cccaagacca ccagctttac ctgcatctgc     1440

aagaaggaca agaaatccgc ctacatgacc gtgaccatcg atagtgcc                  1488


<210>  70
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-6C G397L protein sequence

<400>  70

Glu Tyr Val Asp Glu Lys Glu Arg Gln Gly Glu Ile Tyr Pro Phe Gly 
1               5                   10                  15      


Asp Glu Glu Glu Lys Asp Glu Gly Gly Glu Ser Phe Thr Tyr Glu Lys 
            20                  25                  30          


Ser Glu Val Asp Lys Thr Asp Leu Phe Lys Phe Ile Glu Gly Gly Glu 
        35                  40                  45              


Gly Asp Asp Val Tyr Lys Val Asp Gly Ser Lys Val Leu Leu Asp Asp 
    50                  55                  60                  


Asp Thr Ile Ser Arg Val Ser Lys Lys His Thr Ala Arg Asp Gly Glu 
65                  70                  75                  80  


Tyr Gly Glu Tyr Gly Glu Ala Val Glu Asp Gly Glu Asn Val Ile Lys 
                85                  90                  95      


Ile Ile Arg Ser Val Leu Gln Ser Gly Ala Leu Pro Ser Val Gly Val 
            100                 105                 110         


Asp Glu Leu Asp Lys Ile Asp Leu Ser Tyr Glu Thr Thr Glu Ser Gly 
        115                 120                 125             


Asp Thr Ala Val Ser Glu Asp Ser Tyr Asp Lys Tyr Ala Ser Asn Asn 
    130                 135                 140                 


Thr Asn Lys Glu Tyr Val Cys Asp Phe Thr Asp Gln Leu Lys Pro Thr 
145                 150                 155                 160 


Glu Ser Gly Pro Lys Val Lys Lys Cys Glu Val Lys Val Asn Glu Pro 
                165                 170                 175     


Leu Ile Lys Val Lys Ile Ile Cys Pro Leu Lys Gly Ser Val Glu Lys 
            180                 185                 190         


Leu Tyr Asp Asn Ile Glu Tyr Val Pro Lys Lys Ser Pro Tyr Val Val 
        195                 200                 205             


Leu Thr Lys Glu Glu Thr Lys Leu Lys Glu Lys Leu Leu Ser Lys Leu 
    210                 215                 220                 


Ile Tyr Gly Leu Leu Ile Ser Pro Thr Val Asn Glu Lys Glu Asn Asn 
225                 230                 235                 240 


Phe Lys Glu Gly Val Ile Glu Phe Thr Leu Pro Pro Val Val His Lys 
                245                 250                 255     


Ala Thr Val Phe Tyr Phe Ile Cys Asp Asn Ser Lys Thr Glu Asp Asp 
            260                 265                 270         


Asn Lys Lys Gly Asn Arg Gly Ile Val Glu Val Tyr Val Glu Pro Tyr 
        275                 280                 285             


Gly Asn Lys Ile Asn Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys 
    290                 295                 300                 


Pro Lys His Lys Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro 
305                 310                 315                 320 


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
                325                 330                 335     


Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser Asn Val Ser Ser 
            340                 345                 350         


Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu Val Asp Asp Ser 
        355                 360                 365             


Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro Lys Tyr Asn His 
    370                 375                 380                 


Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro Asp Cys Phe Phe 
385                 390                 395                 400 


Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro Ser Asn Ile Val 
                405                 410                 415     


Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu Tyr Tyr Glu Asp 
            420                 425                 430         


Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Leu Ile Val Gly Ser Ile 
        435                 440                 445             


Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys Asp Lys Lys Ser 
    450                 455                 460                 


Ala Tyr Met Thr Val Thr Ile Asp Ser Ala 
465                 470                 


<210>  71
<211>  1422
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pro+I-CSpep-6C G397L nucleic acid sequence

<400>  71
gagtacgtgg acgagaaaga gcgccagggc gagatctacc ccttcggaga tgaggaagaa       60

aaggacgaag gcggcgagag cttcacctac gagaagtccg aagtggataa gaccgacctg      120

ttcaagttca tcgaaggcgg agagggcgac gatgtgtaca aggtggacgg aagcaaggtg      180

ctgctggatg atgataccat cagccgcgtg tccaagaagc acacagctcg cgacggcgag      240

tacggcgaat atggcgaagc tgtggaagat ggcgagaacg tgatcaagat catccgcagc      300

gtgctgcaaa gcggagcctt gccaagtgtg ggagtcgatg agctggacaa gatcgacctg      360

agctacgaga caaccgagag cggagataca gccgtgtccg aggatagcta cgataagtac      420

gccagcaaca acaccaacaa agagtacgtc tgcgatttca ccgatcagct gaagcccacc      480

gagtcgggcc ccaaagtgaa gaaatgcgaa gtgaaagtga acgagcccct gatcaaagtg      540

aaaatcatct gcccgctgaa gggcagcgtg gaaaagctgt acgataacat tgagtacgtg      600

cccaagaaaa gcccctacgt ggtgctgacc aaagaggaaa cgaagctgaa agagaagctg      660

ctgagcaagc tgatctacgg cctgctgatc tccccgaccg tgaatgagaa agagaacaac      720

ttcaaagagg gcgtcatcga gttcaccctg ccgccagtgg tgcataaggc caccgtgttc      780

tacttcatct gcgataacag caagaccgag gacgacaaca agaagggcaa ccgcggcatc      840

gtggaagtgt acgtggaacc ctacggcaac aagatcaatg gcaacaacga ggacaacgaa      900

aagctgcgca agcccaagca caagaagctg aagcagccag ccgatggcaa ccccgatccg      960

aacgccaatc caaacgtgga ccccaatgct aaccccaatg tggaccccga gaagaaagtg     1020

atccacggct gcaacttcag cagcaacgtg tcctccaagc acaccttcac cgatagcctg     1080

gatatcagcc tggtggatga tagcgcccac atctcctgca atgtgcacct gagcgagccc     1140

aagtacaatc acctcgtggg actgaactgc ccaggcgata tcatccccga ttgctttttc     1200

caagtgtacc agccagagag cgaggaactg gaacccagca acatcgtgta cctggatagc     1260

cagatcaaca tcggcgatat cgagtactac gaggatgccg aaggcgacga taagatcaag     1320

ctgttcctga tcgtgggcag catccccaag accaccagct ttacctgcat ctgcaagaag     1380

gacaagaaat ccgcctacat gaccgtgacc atcgatagtg cc                        1422


