                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
       ROCHE INNOVATION CENTER COPENHAGEN A/S
 
<120>  ANGPTL2 ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF

<130>  3338.144PC01/ELE/C-K/DKC

<150>  US 62/828,864
<151>  2019-04-03

<160>  209   
<170>  PatentIn version 3.5

<210>  1
<211>  35417
<212>  DNA
<213>  Homo Sapiens

<400>  1
gcctttctgg ggcctggggg atcctcttgc actggtgggt ggagagaagc gcctgcagcc       60

aaccagggtc aggctgtgct cacagtttcc tctggcggca tgtaaaggct ccacaaagga      120

gttgggagtt caaatgaggc tgctgcggac ggcctgagga tggaccccaa gccctggacc      180

tgccgagcgt ggcactgagg cagcggctga cgctactgtg agggaaagaa ggttgtgagc      240

agccccgcag gacccctggc cagccctggc cccagcctct gccggagccc tctgtggagg      300

cagagccagt ggagcccagt gaggcagggc tgcttggcag ccaccggcct gcaactcagg      360

aacccctcca gaggccatgg acaggctgcc ccgctgacgg ccagggtgaa gcatgtgagg      420

agccgccccg gagccaagca ggagggaaga ggtaaggggc cagctctgcg gccatgagag      480

gcaggggcga gaggcagccg ctggccccgt ggctagggct tccagaaccc tgaccctcca      540

gctgggggtg tgtgctgctg gatctcagag ggtcactccc tgctatcgct tggagccaaa      600

cgaggcatgt ccggggcaga acctgtggac atttggtggt gtttgggggc acatgatcat      660

gggctggcat ctcgaggact tcatgagtaa gcctcactct cctcttttgg acaaagagcc      720

tttggggtgc cggccggcag ctcccggcac ggcagagcag ctgggagtgt gcgtgtgtgt      780

aggtgtgtgc ttagagggca gcgtactgaa gagctgcaga aggcaggggt ggcccaagga      840

cttgggtagt cactttgaag ctttggattc ctatgccccc aggccgggac aatgtgaggc      900

aaaggcaagc gctgtgctga ggcgctggga gcccctgctc ggagagttac aggagctggg      960

ctgcctctgc tcacaccctc cagctggcga ggagagcaga ggcacccagc acgggaacgg     1020

acgcatcacc caggggctgc tgcactggat ggtaccccgg gtctccaact gagtggatgt     1080

ggccaagata cagggaggat gcggcttccc tggtaccccc gcaaggggac agcaggggct     1140

ccacatacca agtcgcctga aagcactcag tattagataa catttccaaa caaattcttc     1200

actgatcctt cccttctcct tctatgatat gtgtgtcatg ggtcagctct tgcctctgct     1260

gtaggattat gagagctccc agaggccagt tcagttactt ggaaaagcat ctcctttcac     1320

cccactctct ggggaaaatt gagaatgcca cttccaaagc cggccaaatg ctccccacat     1380

gtatttttcc aaatggaggc agagtagggc agtcctcatg agctggcttc aaatcccagc     1440

tcttctacct actagccaat ggctctggca gaacacttag cctttctaaa cctcagtttt     1500

cttatctgtg aaatgggata atactgccca ggtggtaaca atggccagag agtaacagct     1560

aacacttata ttgcacttac tctatgccag actcaacttg tagaatcctc atgaccaccc     1620

tatagcacag gcattattat tcatccctgt tttataggtg aggaaactga ggtaaagtaa     1680

tgtgcccatg gctacatggc tagtaagtgc caggaccagg acttgaaccc agtggtgtgg     1740

ctccggagcc actcaaccac accctactgc tttctaggag aaagctaggc gcccatgcct     1800

aggaaggcct tggcttagtg cctggtgcac agcaaaccct gagcaaacct tggtcactga     1860

tgattacaaa ccacaacaat caggactggc acagagggaa gggaagagca gagacacgaa     1920

ttcttttttt ttttttttga gatggagtct cgctctgtca cccaggctgg agtgcagtgg     1980

catgatctcg gctcactgca aactccgcct gctgggttca cgccattctc ctgcctcagc     2040

ctcccgagta gctggggcta caggtgccca ccaccacgcc cagctaattt tgtgtgtgtg     2100

tattttcagt agagacgggt ttcaccacgt tagccaggat ggtctcgatc tcctgacctc     2160

gtgatccgcc cacctcggcc tcccgaagtg ctgggattgc aggcgtgagc cactgcaccc     2220

ggccagagac ccaaattctt tccctgttct ggacatatcc tgctagggtt ttcagaaaat     2280

cccacgagac agagataata ctgtggctac tatcactgcc cacactggag ggctttccag     2340

gagcctgagg agaggggggc tttatgtctg gggtttgggt ttggggccac ctgcagcatg     2400

cctgcatcct agaagtccat actaagaaaa agtgcagaca tattaacaaa aggatctaat     2460

accaacctta caggaggaag ggcatcctgc ttcccacatg ggcactgcct gtctgcctat     2520

tgatctcccc agcagaacca tagtggataa gaaaatgcag ctaccttagt gctgtgggaa     2580

gctcacaaaa tcaggaggat ccatagtcag gtttgccccg gagttgcaga ggaagaggca     2640

aggaatggcc atcaccaagt ctggcactat ggtggccatg tctggtggat cttacaccag     2700

acaacactga tacatcttag cccaggagag gagcttctgt gctgtggccc cctgaggttc     2760

cagtgggctc cctgcacgct tggaagcatt ttgaaaaggt gacatcaagt atttgcttct     2820

ctagcacaag gcctctgggg ctactgaagc cacaggtttc cctgctccag cctggaacca     2880

tggtggctca ctgtcttctc tgggcagctt aggatgagca gaggctctga ctgacttcat     2940

gagcttggca aaaaaaatgg gactacttac tactaatgag gcagtctggg tggaacagac     3000

aaaaatgtgt aacgcacatg gtccagcagg ggactacatg ttattgctga agctcacggg     3060

cagagcaaat aagctgttcc tccatctggc cctccatccc ccagtgattt aggaagtacc     3120

cactgggcta aataaggcat atacattatg tcatttcatc ctcaccacaa ccctagaagg     3180

taggttctag ttttagcatc ccattttaca gatgggaaaa ctaagtctcg agaggttaac     3240

ttgcccaaag tcacacagtt atgtgattat gtgggactgg aacccagctc tgtctggctc     3300

caaagcccct gacttcctct cacttcagtg ccttgtttag acacctcaac ttctcttatc     3360

ctgactgtca ctgggtccct gcccagtgtc gtcagtagcc acatctgctt tggttgctgt     3420

cctatcgaat gctgcaccaa cccctctgaa aaccatggac ttactcaact ttagcgcatc     3480

ccttgctctt catggaagcc tacttctgag gcaaaatagg catgactgtt actcttagag     3540

atgagcctca gcacagttat gagggtacct gttatgtggt aatatggtca gtgacaagag     3600

gaactgagct tcgaaaccag gttggctgac ttgttccacg tgcctgggtg ctctgcgata     3660

ctgtctcacc acatcagcac caggaaactc tgtccccagc tcagtggggg cagagcctca     3720

gggaaacact ggtccatgtg actaagatac tattgatgcg ctttctacat ccgtacttgg     3780

aggctccttt aggactgaag aatcagagct caggtcctca tcacccacac tgggccacac     3840

acgagcaatt tctgagaaaa catcagggag atggcaatgg gtagctacaa tagaacaaac     3900

ataacagaca gcagccctgc caaagcaggt acattcagca actggcctct ctgaatcaca     3960

gcccatttaa tctggaatgg tctcaactga cagcaggcag atgggggagg ggctctgctt     4020

catagagccc acagcccagc aggactgggc agacagtaaa taatcacaca aacacacaac     4080

tgtgtgaaag ctgtaaagag gtggcacaag gagctaagag ggtcctcaag gtgggtggtg     4140

ctgtccccgt cttacagaag tggaaactgg gggtcagggt gcagcacctc tcccacggtc     4200

tctccatgca tgggccaaaa agcaaagatt gaaacccaga cctgtgctgg ttccacccca     4260

gcctgctgcc atcctggaca accacactgt ggaaatctca agaaagaatc aattcattga     4320

atagcatttc ttttttgtga atttatataa aacaccccaa atagaagagt tattcagcca     4380

caggcagctt ggagtttgtg gtgatacact ggtcacgtca gaagcctcat tctgggggta     4440

gtttctatga caaaactgtg ttctttcaca tggactgtga gccatatgac tgagttcata     4500

acagtgttgg gggttacaac gttacgatgg cctgtcacat gtacacatca atcacaagcc     4560

acattttggt cccaggaatg ttaaaatgtt gggtgtggca ggagaatccc ttgaacccgg     4620

gaggcggagg ttgcagtgag ctgagatcgc gccactgcac tccagtctgg tgatagagca     4680

agactccatc tcaaaaataa aaaataaaat gttgggtgtg gggagccagg cctctcacaa     4740

ctgaactatt gtgtcagtcc attctctgct gaaatcagcc tgtctggggc cagcagcccc     4800

agagcctcag caaccccctg ctgcctagtt gtccagacag gcagtaccaa gaccaccaag     4860

gaaaagccca gaatggactc tgttcttatc ttcaagagat gcctgaggac ctgcccagct     4920

ccaagaatcc ttaaagtcct gcctgaggtg gtcccactcc aacctccatg agggaaaggc     4980

tgtgtctgtc tcagttactg ccgaatctct aatacccact cagggccagg tagaaaagat     5040

atctgtggaa tgaatgaatc aatgaagcaa gcctcaggcc caggctctca agcaaacaag     5100

cttctctacc ccagggtgcc acaccattcc tctctctgtt gtccagccaa gggcttttct     5160

gaggctaggt caggtgcccc acagcccccc aagtttccct atctgggcat ggatctcttt     5220

gcattacaaa tgcctagtct ctgtctcacc tactaccgtg gaccccttga gggtaaggac     5280

ctcacccacc ttgttcctgt tctacctcca gccgctggca cagtggctgg aagaggagaa     5340

cttattggga aatacattat acaaatgaag ttcttgaatt cctatttagt aacctaggtg     5400

ccatcctgga tactcagtag tcagaggagg aatctgccct ggccctgctt tttaaagaag     5460

ctgtagtcag gagggagata accagatgac tgcaatctga gtcttgggtg ttgagttgga     5520

agcagccaca gctgcacttg tgagctgaag gagggaggga agacctcact gaatggatgg     5580

cttcatggtg aggtcaactt aggaagacag gcaggcatca gccaggacag tgggggaagg     5640

tactcgaggc aggaagcaca gcacatgcaa aggcagggag gcatgacaac acaaggtctg     5700

tttttaagca ggacgctgac atgatcagat gtgggtgtca gacagacagc cctggagctg     5760

catgcagtgt agactgcagg ggagagagca cccaaaggca gggaggccaa ttaggattgt     5820

gtgggtaaga aacctggccc tgggttagac aaatctgtta ctgggcccag ctccaccact     5880

tggtagcact gtgcccctgg acaagtggct tcatccctta cctttgtttg ctcatctgtg     5940

aaatgaggat agtcatagcc cctgcctcaa agagctaccg ggatcagtga ggcagacaca     6000

aacattggtt gtcccagtgt ttgaggaaca agtccatcca aacagccaag gtggccctgg     6060

tgccaacttc tcagcctggt ccagaaaagc agccccaggc aaggcctgga cttcccaaga     6120

aagtcaccct ggggcagtgc tgtccaccca gcccttgact tctccctctt gtctagggct     6180

ttcccagttg tagggctcca gagcacacta ggcactgccg gaaatgcagc agccaactca     6240

gaagctggac tctgaaatgg cttctgcaga ctcttccccg cctctgctct gttggccaag     6300

gctcctggca cagaggcctc agtgcacaga ctttggggga atctcaaaat ggttcccaaa     6360

taacgcactg tgaaaaagta acagcagtgt ccttgtcccc cggaaaaggc aaccagctcc     6420

cccactccct aaccacatcc ccctctaccc tatgatctca tggtgtgacc acaacccgcc     6480

tcctccatga actcttcctg gagccagcaa ttcaccaatg gcaggagcac aagagcccaa     6540

agcatcaggc agattcgaac ccccagtgct actcctccag gcaaatctgt cttaccctgc     6600

ttctctgact catggctccc atcacccatg acaggtagta gcaatgcaca atggctagct     6660

gcatgggaag gctaaatggg tgggtgatgg agggctggat ggatggataa atggttcatt     6720

caatggtctt atgagagctg aactagaagg gtttgggaat tgactccaga ctccccaggt     6780

gccttctggt ggggaatcat tcatagcatc ctcagccagg aggggagggc agctggagat     6840

ctggatatgc cctccctggc ctccgggctg atggtgaatc atccaggaca aacaatgcac     6900

agtcctttca ccaggttctc caaggtgagg gtgtcactgc tcatcccaga tgcccatttt     6960

ggggtcttac cacttgcgtg atcaagcagc tctttccaac atccaacaaa acacaccctt     7020

gtgctgacct gaaagctatt tctacttatt cagtcaacag tgagtaacat gcaagctgca     7080

tctcagccat taaacaaaca agcacctttt attcatactg gttgaagaga caatcttgat     7140

gcaaggcagg gtttggacct agcagttgac agctaaatcc cagttgtgat atttacttcc     7200

aagtgatctt gaacaagcga cctaaccttt ctagacttgg gtttcctcta ctgccaaatg     7260

cagatataat acctttctct taggtaatgg gatcatatag tttgttgctc agtcaggaca     7320

atattgagag tgaaaagggg gtgctattaa taactacata agaccgcaac cagcatggcg     7380

aaaccctgtc tctactaaaa atacaaaaat tagccaggtg tggtgacagg cacctgtaat     7440

cctagctgct caggaggttg aggcaggaga actgcttgaa agcgggaggc agaggttgca     7500

gtgagctgag atggtgccat tgcactccag cctgggtgac aagagcgaaa ctccatctca     7560

aaataataat aataataata ataattacgt aagacaacag acctcaactg gggccaacca     7620

ggatgtatgg tcccctactc atagagctat taagagccaa tgagatagag tacagctggg     7680

cacccaaatt cacaacaaac gacagccatt attagcaata ctactggtca cctgatcagc     7740

tgggcctttt ccttcatctg gatccctccc acatcttgga ttaccaactg gtttggatac     7800

ttccctacca gcacaccata catttcaaca gcttagtagg aacacctgct agctaatgtt     7860

gatgttttca tctgtcttct gtcctgatga tagtttcaca aacttgattc atgctcaggt     7920

ccaccagact cactcaagca cagctcaggc ttctagcttc ccagaacccc gacgtcaggg     7980

gccagctggc agttccagat tccctgactg ccttggcaga ggcccgcttc tcaggcctcc     8040

tgcagtgctg ggatgcctct tatggcgtgg acccattatt ggccttcatc tgtgatcaca     8100

gaccaatggg cagtgctgac cagaggacgg gtggtgaggg ggtggttctg taagtcctcc     8160

aggcaggact acaacctgga ctgatgatga atcaactcct gagatccgga tttaatttgg     8220

aggcttccct gggatctgca ggcctaatga cggcaagagc actcctgtcg tcgtcctgcc     8280

tagagggtca gagaacaacc tcttttgggt ttccagtcac tttggcactt tggtttctct     8340

ttattcacag tatggtatct ttgggggtta ttttgggatc tgttagtggc tctactactt     8400

attaatttgt gatttgggca aatgactcac gatcctcaaa tctcaatagt ttcctcaact     8460

gcaaataggg ataaatgtca gctttgctgt tagccttaaa agtatctttg tgggcatcag     8520

aaaattgcta caatataaat ataaaaaaca taaagactat gaatgtgagt tgtgtcccct     8580

agagtagcac agtgctcaag tggggccacc atgcatggcg gccctcaaat aacaggccgc     8640

cttccgaggg ctgttgggaa gattaagtga gataatgtat ataaagtgct tgagccatag     8700

tgacaattta ttgttgttat tcttttaatt gctggaactt ttctcatttc taacctttgg     8760

ggtgaactca aaagaggatc ccaggccggc agcttctgct gcagggcaga acacacagct     8820

ccatctgatg aaaatgacag ctcttcccac aaagtggccc cttgcttggg ctgtggcacc     8880

acagtggtga gagggatgcg gacacatgat gtgtggcccc accacatcag gccaagcggg     8940

gacattcaga ggcagcccac cggagactgg gtgggaccca agccctggag aggctgcctc     9000

ccagtgtaca aaggctgtca cgtggcacag tcacaccagc ctcacttgtg gggagggaaa     9060

acccatgcgt gatggaaact cctcacaata caatgtggaa aagcaatttt aagaatcgtt     9120

tttattttaa ttctgaagcc aaggaaaaca gttggatttg cttttctttg ttggacacag     9180

gaaaaaagtg aggagcatca ctttgattgg agttgagttc ttcttcagtc ctaagatggc     9240

tggaatgccg gggtgggggt ggggggtgtt acttctcttg agatacaatg agttgaataa     9300

atatcaagag agcaaaagta aacaaactta ttactgccca ttaagagccg ccaaactggc     9360

aaaaaactgc tggggggagg ggaggaattg gggttggagt cttggactcc aaggaaaata     9420

aatgactctg aggctcaaag agaagcccaa ggagcatggc ccttggtatc aggttgaccc     9480

aagtcctagg ctcagtcacc tttggctgtt atctgccgtg tgttcctggg caaatcactg     9540

agcctgtttg ggttgcaatg tctccgttga taaaacaggg gtgaataaca acccaccgga     9600

ttacctggga caatgtatgt caggcgccca gcacagtgcc ctgttccttc ccttccttcc     9660

tgtaacccaa tcagttctga gtcaccccca ctaagcctag gccccacaga ggtgtaacag     9720

taggactcag aatcaatgta gttacaagag gtcccactgc tcgcaacatg acctcaaagt     9780

cagctacccc tacacctttt tgagcttcag tttcctcagc ctagaaatgg gcataacact     9840

agtaagtcac tctgagtgtt ggaatgatta gatgagagaa tgttgatgtg aagggtctgg     9900

aagccctaaa gccctgtgca agcattagtc aaggagatgg tgtgagtgct tggcacactg     9960

cctggcccac acccagcatc ctcactgttg ttggttttgt ttcagctttg ttgttcttgc    10020

tatcgtattg ctaacacatt attccaatct cccgcttctg atgcacttcc atgctgctca    10080

cctagtgtgc aaggtgggtt ggatcatccc atttcacaga aaagactcag cctttgaggt    10140

ctcaagtgca atggcaagaa ctctgtcggg gagctgtgag agcccatgtt tgggagagga    10200

tagaactcaa ccataaatag tgcaaatcaa atctggaggt ccaggaaggc ttggaaacca    10260

accttgtctt gcagccaggt tgcctcctgg gcctctggca gtttcttggc cacagtggag    10320

ccctgcgccc acatgggcac agagaggtgt ctgtcaccca ctgcctcagg tgagcagcct    10380

gaagaaggcg ttggcccagc aggcctgccc tagcccaggg tcgggggcgg ctcctcccca    10440

ttgttctggg gtgggtgtga ccactagcac aggggcagcc aaagcaccgt tggaaacgag    10500

gcaaacactt ccaaactcag ctgggtttcc actgacgtca ctgcagcccc acctcctagc    10560

agagcccaaa ccagaagctc ccacacacct ttctctgcct agcctcagag aggcctgagc    10620

aggccatagg aatcatgctt gggctttgtc atttaagtgg aaaacagctc agcaaggccc    10680

cagggagcac agggtctctt ttgtaactgc tcactggctg gtccaaggtg gagcccagac    10740

ccagggtcct cactggagaa gcccccaaag gggttcaggg aggacaaaat ctttaggtcc    10800

tgtgtcatac ttgttatttt agcacagatt aatgtgaaat cagaaagtag tgatgctaat    10860

acccttttac tagtaaaaac cagattaaat acatgcctgt gtcatcgtta agagttagca    10920

ggttccaatc cagcagacca gggttgagcc ctggttctgc caccttctag ctttctgatt    10980

ttgggcaagt cactcagcct cactgagtct cagtttcctc acctgtaaaa tgtaaacagc    11040

aacagtatct accttaaaag gagattatga gaacacggga aactggaaaa cacttgcaaa    11100

atgtttagtc cagggtcagg tatatagcgg accttggtca atggatgtta ttaataaata    11160

cacacatagg ccctcctctg cgcagctctg acctcctcag gcagtcactt gtccatggga    11220

tccctgcccc aatctatccc tctttccagc actcccagct gctcagcagc tgttggcagg    11280

tgtgtcttgt cattccatca acaaatattt attgagctcc tatgtatttc aggccacgtg    11340

gtaggcactg cacatggagc agtgaccaac acaaacacct ccctaccatc atgcagcttg    11400

cattcaaggg aacggggagg agacagcgtg tatcttatgg tgataaggac actggagggg    11460

gaatgtggtg aggtcacaat cttaaatcag cagggagggt ctaactgaga aggtggtatt    11520

tcagcaaaga ttgaaagagg taagggaaca aacaacgaag aagggggcag ggaccagcaa    11580

gtataaaggc cctgagtcct aactgtgctt agaacacttg acagacaacc aaaaggtcaa    11640

ccaggtggtt ggaggagatg atcgtagggg agaggggtca gagatgagac cagggaggaa    11700

gtgggggcca gatcatagag tgccttggag acccactagc ttttcctcca agatggtgag    11760

ccactggggg gttttgaata gaagagtgac cccgtttgac tttttaaaaa ggaccactct    11820

ggctgtgaag ttgaggacag aaggtaggat gggcaaggct ggggcaggga ggctagttag    11880

gaaattactc caatagtcca ggtaaatgat gcaggtgggt tgcaacaggg tggtggcagg    11940

gaggtgggga gacacaggac tctaagaata tttctggcat cgtaatttgg cggtgaatta    12000

gatgtggggt atgaaagaaa gaaaggcgtc taggatgact tcaagacttt cggcctgagc    12060

aaccagagtg gacatttatg aacacaggaa aaactgggat gaacaggttg ggttggagat    12120

acggggaaaa acgagttcat ttctggatga gttgagatac ctagcagata gtcaagtgga    12180

aatgtcaaaa aagcagctgt atgtatgagt ctagagtcct ggggagagtt ccagaaataa    12240

atgcggatgt aatcagtact tgagggtgat caccaacgtg acctctggat gagatgacta    12300

aggtaaagaa aattctgagg actgagtttt gggtcccctc aacagtagag aaaggacagg    12360

aatatgagga tgaaccagca caggctctga ggaggaacag ccggcaagac aggaggcagg    12420

gtggcgctct ggaaaggaag gtcaagaagg gagcccaact gtatcccaca gtgtgagagg    12480

gaaaatatta atgaggatca agaaccagcc cttccatctg gcaaacagac aggggatcct    12540

gtctagggca acctagaatg aaggggagcg ggcaaagcct gatgagggtg ggctcaagag    12600

agaccaggaa gagaggaact ttctggaaat ggtgagtgca ggcatctctt tggaggcttt    12660

gctaaaaagg ggagcagaga aatgcaacaa gagctgcaga ggggatgtga ggtcaagaga    12720

gggttttaag ttgagagaaa aaaccgtatg attataggaa aaccatcctg atgttgggga    12780

gacggtgagg actgctggag caaggccctc gagtgggcaa gagaagggat ctagcacgtg    12840

tcctcccctc cctcttggcc catttaactc ctactcattc ctcaagggtc agtgtaaagg    12900

gcactttctc agggaagcat tcctgaccct ctaggtcaat tccctgtaat actcctttac    12960

agcatgtgac agttgtgctt tctggcattt gggaatggca taatgatgtg aaagccccat    13020

gagggcaggg actggctcca tcctgttggt agctgtatcc ctagccacta gcatgctgtc    13080

cagcaaatca caggtgttca atcaacatct ggtgaaagga tgaatggtcc aagaatagaa    13140

gtgaagcaaa tctggagaca cattctgtgt tctgctccct tctaacttaa tcacgttgca    13200

gtggtcagga ctgtgctgtc actggctact gcaaatattt ggattcagaa gagctcagtt    13260

gtttgttcct gttttggctc tgtagcttag ctaacacagt gaccagagcc acgtaactgg    13320

acacatcctt ccactgatat tgtccactaa accctgaatg tattccataa catgtctaac    13380

gattcatttg tttatcaaat atttgcccaa agtgcaatat cctgggaata cagggttgaa    13440

tcagacagac gacatgccct catggagtta gaatccaaca gagaagatca aacagaactg    13500

ctattcagca cagcggtgat gggtattaca aggggaaagt tcagggggtg tgaaagtata    13560

gaatagggag actcaacagt ctgaggaacc aaaggtagca gaagagagag accagaaaac    13620

cctccctctg cctcccctcc ccagcctgaa gctgcctgga tacgattctc aggctctagg    13680

ccaggagttc agcaaggggg ctgcgggcat tggagctggc tctgggagta gcagggccat    13740

ggcctcctgc cttcagatgc cctgagaccc tccctcttcc cttctacctc tgctggggct    13800

tgcctgtctc ctcttgcttc cagaatggct gcctgttctc tgactccaag agaatataac    13860

ccagcatcct gaagcagagt ttttggaaag ctctgcctgc ctggcgagaa ggctgggatc    13920

actgatggca cagggcactg acagtggtgg gaccatcact gattctcccc tctgtttact    13980

ttcaggcttt catagattct attcacaaag aataaccacc attttgcaag gaccatgagg    14040

ccactgtgcg tgacatgctg gtggctcgga ctgctggctg ccatgggagc tgttgcaggc    14100

caggaggacg gttttgaggg cactgaggag ggctcgccaa gagagttcat ttacctaaac    14160

aggtacaagc gggcgggcga gtcccaggac aagtgcacct acaccttcat tgtgccccag    14220

cagcgggtca cgggtgccat ctgcgtcaac tccaaggagc ctgaggtgct tctggagaac    14280

cgagtgcata agcaggagct agagctgctc aacaatgagc tgctcaagca gaagcggcag    14340

atcgagacgc tgcagcagct ggtggaggtg gacggcggca ttgtgagcga ggtgaagctg    14400

ctgcgcaagg agagccgcaa catgaactcg cgggtcacgc agctctacat gcagctcctg    14460

cacgagatca tccgcaagcg ggacaacgcg ttggagctct cccagctgga gaacaggatc    14520

ctgaaccaga cagccgacat gctgcagctg gccagcaagt acaaggacct ggagcacaag    14580

taccagcacc tggccacact ggcccacaac caatcagaga tcatcgcgca gcttgaggag    14640

cactgccaga gggtgccctc ggccaggccc gtcccccagc caccccccgc tgccccgccc    14700

cgggtctacc aaccacccac ctacaaccgc atcatcaacc agatctctac caacgagatc    14760

cagagtgacc agaacctgaa ggtgctgcca ccccctctgc ccactatgcc cactctcacc    14820

agcctcccat cttccaccga caagccgtcg ggtaagtgct tctgggatcg tgttacatgt    14880

gggtctcaga gccaggcacc aggcttccct tggctgtgtc cacaaatggg gaaaagccat    14940

ggccagttga agccaggcca aagacatgca caatccccca gcaatccctt gggctgagct    15000

gctggagcca gcagggtgac gggtggcagg ggaaccacat tccttagatg gatcctcaaa    15060

gatattacca aaaaatggag tttcagaaga gggcaaacac tctctggttt ctgacaggaa    15120

agaacccaga gcctgtagtt ttctaggctc tgcatgagat cccgtgtgtt ggcagataga    15180

agagaatgtc tctcctgcag ctcatgcact gtgcctggca cagggttggc cttctgtaaa    15240

tgttcaccaa ataaacaatg ggccaaaaga aaagaaagta ttacccatgt taagaatatg    15300

ataaacacat tgtaggggct gggcatggga aggagtcctt cctaaagccc acacacttcc    15360

tagagtctgc tgctgtctag aattttcaat gatgcttcca tatgctctta catacacgtt    15420

tcatcttaaa atacagcaat tctccgaata ccgttatggg ggaggaatgg gattgctggc    15480

aggttttaaa gcttaaccaa gatactggca ccggacattt ccatgtatgt tacataatta    15540

actcctggag ctccttgcgg acaggatgaa taacttgcta ataggcttag gatgttcagg    15600

ctagatttgc attcaggtct tttcacttta aatctctggc tgacttctct atgctctagg    15660

actctaggaa tcatcatttc tggaagaagc aggccagagg ctcccctgtc agaatgtcag    15720

cacacatcca gtcccctgaa gctcagcccc ttgttcatcc agaacacctg agccttccca    15780

gtgggctgcc atatgagaac tatattcatc tctgcataaa tgaaccatgt atctactcca    15840

agtcagtgct ttcggtacca tttcattgta taggcaggga gagattttta ctgaaaatat    15900

cctgctttac acttatttca cacttttaaa aataaccacc agtactggga atagcagctt    15960

cttgctaatt ccaaagaggg gctgaacctg agtgcaggag ggtggccagt gcagaggaca    16020

agggcagcat tgttttcaga tggggtgggt gaggtgagct aaatgcaaag tgagcatcca    16080

ctgcagcacc tcaaaggaaa gacctggcct gggtgcagga ttgagagcag gcgctttgga    16140

gtaggctggc ttggatttaa atccggtttc caccactgat tagctctggg acattaggca    16200

agtcactttg tccccctgag gctcggtttc ctcatctgtt aattgaggat agattaaaat    16260

agtgcctgtc actttaggaa acgaaatact gcaaaaaaca tgtttagcac aatgctgggt    16320

ccacggtaaa ctacaagcct cctttgatct aggtcttttc atcttaaaac aaggagactg    16380

aaataaacag tccctttttt agctctggcg ttccatctgt acacgtgtct gctttaaatc    16440

agaagctctg aaagagaggg cagggtgtgt taatttgtct tgatagaata ccgagagggt    16500

aaaacgtgcc cttgggcacc aaacaaaggc tcagttgaat gttgttataa ccctgactgg    16560

agacaggctg gactcaatgg ttactcaaca gatctcctct ggcctaagtg tctctggttt    16620

ctaactcaaa acatttcagg acattcctgg gcttgaacta agctggcaga tacatagtat    16680

aggaataaga cctgggtttg catccatgct ctaccccttg gttagctgtt cgctcatgag    16740

atagttattt aactcttctg agcctcaatt ttctcctctg taaaatgggg acaagggtca    16800

taacctcaca gtgttatgct gtggatacaa tacaatcaag catgaaacat tatgtcatgt    16860

agtaaagcca acatttgctg agcccctact acatgctagt cgcagcacta gacttgggga    16920

agtaggtgac aattgtggtc cctgacctcc agaaactcag tctggggtag acggcaggtg    16980

catgaatgca tctgggatcc gtccaatgcc catgatttct agtccctaac atcagcacat    17040

cagatctgac aatggatttc tctgggaggg agtatccgtc gaggccaaaa tttctaaaat    17100

caggaatgca gtgaaaactg ggctgtctga tcactgtggt gataccctgg tgtgctaagt    17160

gccctggggg acagtaaggt ggcatgacta attctgccta gagggaaggg agagattaga    17220

tagacgtggc acttctttgt tgcatcttga aggatttgta agattttacc aggcagacct    17280

gggagttggg aacccaagtg actagtgggt ccctgatgga gatgagtctg tgcaagggcc    17340

caggggcaca gttctattcc tggcacctca aatggttcaa tctcctgctt ctttgtgttc    17400

acaacccagt gtgggctgtg tgtatccaag tgtcctgcac tcgcccgtct tttgtctccc    17460

acttaagaaa gcacgccgtc atgggaggga atggcagtga tttcatcaca gagataactg    17520

gaatgcatta gaatttatcc ttctttgtta cgcaaggatc cccaaatgtt ggtacttgct    17580

cattaccagt agatttcttg tgacccatct caccactgag ctcccacaca aggcgctgcc    17640

agctgggatt gagtgcctag ctgtggaaga tgaatgggta gacagagccc aggaagagag    17700

cagctggggg agggtcctgc cctctcctgg tgttgaggac taaactggga ggaaaaaaca    17760

gatggtctct ctgcacggaa cagtcagggc atccaatgag cagagaacat tcttatcagg    17820

tctgttcaga gagcttgggg caggttctta tcctggaaga caaaacactc ttctgtgctc    17880

ttacccaaca gatcctttgt tcttagggac atcacttagc cagaaatacc tttgcaatta    17940

aacacctttg catccgagcc ttggcagctt ccaaaccttt cactcagcag cctcagagcc    18000

atgtgctctt ttcttcgtct gcccacagca tgcccttccc caggggacta agggagccat    18060

ggctgcttat ctgaagctgt accacaagcc tgttcccagc cttactgaga cagtaacagg    18120

gtggtcccag gccaggatgg cctactgaga gcctgagtga ggaggcacag gcagctcctg    18180

gcttccctgg ctcctcacct gggctttgtc ctgtgtctct caggtctggc cagacccaaa    18240

ggcattttga ttaggatgat tctgtgatga ggcctgggcc aaatggccct atctgtggtc    18300

ctctgcccca cctatcctgc tgctgctatt agaagaggaa ggctccaggg gtcattctct    18360

aagaggcaaa ggatagagca ggcacctggg ttctgggagg cctggtactg tttctcaggc    18420

cacccaaggc agagccacac atttgccagc cctcctgcac agtgcccatc ccagagactg    18480

atcagggagg aaaggacagc gccaacagca gctgccacag acgggctttg tcagaaacta    18540

atctttaaag accaaaagga gtgagcactt ttagctgttt tctctcctga gaaagagaat    18600

acaaccagtt cactttattt ctcaatgagt gaagaagaag gggccataaa accatgaaat    18660

actggaacta ttaggggcct ctcagatccc ctagcatggc cttcctgtaa cagagcctgt    18720

tggtggcaga gcagagatcg accctgggac ttgtaccttg caggatattg aggttcatag    18780

aggtcaagta acttagccaa gggtacacag ctagtaagtg gcttggccaa ggctcaaacc    18840

aaagtatgtt ttaactactc tggatattgc acacttccac gggaaggctg gaggggaact    18900

ggtgtaaaaa tcaccccgtg aatgtctgat ttggccccag ctgccacagg gacctgacct    18960

tctatctcta cttcctgacc ttctagctct acttcctggt accacgttcc aaacagttcc    19020

ttaaaatgag ctctgggaac aaaggtggta gatttgttat tagaacatgg ttccaatgac    19080

acaaaacact gtcgctacca acccaccaac atcatgctcc ccctccctag gcctagcagg    19140

aaccagccaa gctccccagt agaaagtaca acgtgcacct gactcccagc aaatggaccc    19200

aactgaagtc taatttttaa tttttatcaa atctggacat atcctctggg gttccttcta    19260

ctcagcattt caatgtatag ctaagtcttt caacatatag ctaagtgtga agttctgatt    19320

tctttaaatg ttagccctga ctgtataaat gtcagtagac atgaccttcc cttgggacca    19380

catgaggagg tccccacatt gcttcactga caagagtgct agcaggaagc caccccatct    19440

cacaacagat gggctattgg gctatggcca ggatggcatg gacaacttga acaagagtgt    19500

tttcctagat ggattttcca cctgtatttt attccaccct ataaggtagg aaatacgtac    19560

acgattgtgg ttccccagca caatggtatg ttttaaaaca gagaaatata tgatgttgta    19620

gctcccattc tttctggagg tcaagcaagc aaccaggtga aaaggtgtca acccatgtgt    19680

ggctgggtca gcttcagtag gctgggcatc caggcccaag cactgcagag aggtggagaa    19740

gcacagggtg tgtgtggtga tggtggcgag tgagggtgac tctgcccatc ctgagtcagc    19800

cttcaaggtc acagaggctg agggaaaagc ccacacaggt ctcctgcctc cagagcgtgt    19860

gctgtttcca ctgtacaata ctttctttta ttctaaaagg ttttgttaaa caaaataaga    19920

tttcaaattc agtacaaact acataatcca gtgatttctc aaagagcact ctttgctagc    19980

ttcttcctaa acaaaatcta ctctaggaag atggcccacc tggatgatgg ttccaggagg    20040

gccagctccc ttattgcttt gctttctctt cctcctcttc tggtaccttg gggaactgat    20100

cacaaagagc cttttgaggg tgatggaaag ctacccctcc attcctcagg cagttttcca    20160

aagatgacac ttggctaaat gctcagggta tttacagtca taggagataa actatcaact    20220

tgttactgtt aaaaaaatct tgagatctgg gatcttgatg cctgaaaatc ccaagattgg    20280

tacttggcaa actgaaagaa atctagaaaa ccctagagat caggcatctg tggccagcta    20340

actggtcata caaatggatt gttgtggtga acttgtatag tattaatcct gagatgctgt    20400

ccccctccac ccccaccccc acaaaaaaaa taaataaagt agtattaagt tagcctcata    20460

caaatgctgg caccatgctc ctggacttct cagcctccat aactgtgagc caaataaact    20520

tcctttcttt ataaattacc cagtctatgc tattctgtta tagcagcaga aaatggacta    20580

tgttcagtct tgtaaaagta atgaagtata tacttccagt ggtttatacc cacatcagtg    20640

aaggatgcag gcagcagaga cctcttgatg ggaacactgg agatgatctt tcctactatc    20700

cccgcatcac cactgcctca acttcggctc tccctggcat gaatctggtc aaagattatg    20760

ctgaaaataa gcctgatggt cctcatctta tatctcaaga tgagcctgtg gaactacagg    20820

gcctggagta tttatgtgat cctttgttta aaaaaaaata agttactttt ccctgatatt    20880

tttgaataca gtaagtcaaa actactatac acacagagaa aaatcttgct aagacaattt    20940

gtttacgtta taaatgcaac agctcctaaa tgttgaaatt aagtatctta gatggtatgt    21000

ctagagtagg gtccaaatga acaaaaaatc cactcatctg gcaccatccc agacataatg    21060

tgcagagaga ccactacaaa ctgtccaggc tttcccacaa agcaggtttc ctttgccagg    21120

gtttggtctg gatgtggatt atcatctgtt gtggggtctc tctttccaga tggatttatt    21180

attattggtt ctcagctgga aagcacagaa tgaaggtagc aaaggggatg cagctcagga    21240

tggtgaagga tggagggtga aggatggagg gtcaaggata gaggattgaa ggatggaggg    21300

aggcacacag agcattgagg gactcatgga gtgagcctgc aagggttcct gcctgaaagg    21360

agcccacagt cttatgggga cacagatccc caacaatcct aatgtggtgt gataactgca    21420

gcacagaagg tggacctgag ttctaatccc agatcctcca ctttccagtc atgtgatcct    21480

cttgagccct ggctttctca caggtgcagg ggcttatgag gatgaaatga aacggtgtgc    21540

aaagcacatg gcaggtgaaa ggctctagat acatgatcat caccattctt accttattcc    21600

agtagagata aatatacaaa gcattttggg aacactgaaa aggataaagt agctttcctg    21660

gggttgggga aagcttcctg aaggaggtga tgaggaaggt aagggccttg tggtgctctc    21720

agaaccacca ccagtgatag tcaagaaatc atgaagacaa gtcttggtgc cagacaaatg    21780

tcctgctttc agaaaaagaa tgcataccag aaatcacata caactggctt gtggtgaagc    21840

cccagtaaaa ttatagaaaa gagtacacaa agggttcgtg agcatttgga agattaaaag    21900

gtcaccaatg aaagccgaca taggttctta aagaagaaac caatgaagct gatcccttcc    21960

ttggaaaggg ttaatacact cgccaactat gggactgcta cctgtccata tctgtggatt    22020

gtagtcatgg gtctgataag ttcttccatg atgtgcctgc aggacagcac cacagtctct    22080

gacagagcca tggccactct cattagtgtg cctgtggaac cctggggcac tgcccacctc    22140

tacatcagag acctccctca cccaggaagc cttgggtaca actggccact gcccccaggg    22200

agccaaggtg agctgctcac ctctgtacac agtgagacca ctaaagcccc ttctaaactc    22260

ttttttaaaa tgtctttaaa gcccctgttt ctcctcctgc ccaacagcgc tggtggaaac    22320

ctaagagcga cgcaatgctt tggacagtgg cctctggaaa gtagtgctgc aatgtctgtt    22380

tctcccgagg tcaaatgagc agaaacagga cctttataag ccctttctgg gccctaagag    22440

ctcttacttg agaggcctca ggctgtatca catgcattga aatgacctac ctcacacatt    22500

taatagaatt tttactggaa caattttgaa aggatttaat acttttgctt ttaaaattat    22560

ttggctaaga gtaactcaat taatttatgg ttggatctca tttctcagta aacatcaagc    22620

atattcagga attcttggga agtgaaaaaa atctaaccta caagttgttt tcaaaagtag    22680

taacattttc atgaagacaa aatttaacaa ttaatgaact tgacaagatg tcacactttg    22740

tagtaattta attacataca ataaattttg attttgcagt tttcttttca tattttagag    22800

ccagtaagtc tttttaggcc tcaaacattt tcatcaactc ctgaaacact cattggcccc    22860

aggcaccatg cccatcgttt gagggctaaa gcggcctgaa agcaggcaca agcatttgga    22920

ccttttccct ggaatgatca gaaatgacat gtgtgatatc aactctgagg ttctgcagga    22980

actgaaatgc ctttgggacc atacaagcta ttcctgtgtt taggttattg ttttgtactc    23040

tggttcgctg aaaagcagtg attgacatag aatatatata catccataac cagaatctta    23100

ttttgccaag cctctggata aatgagattc gaagaccccc aataactgct tctcactgta    23160

gccacccctc acaccccatc ccccgaccct gtgtgtctgt tctcctgccc tcatggggtg    23220

cccagtgagt cctgatgctg gcctgggtgg gactctcacc taagcaggcc acgtgccgtg    23280

gcactcagat gcattaattt gggtaggaaa ttgcagatcc aatttcaaca gttagtcatt    23340

tctcctgtta gaaaaatgtt tcagggagtg gtaagaagac tttttggaga cagaccatca    23400

gtgagagtaa ctgaaaacag catacagttc tcatgaaaag cagactgcat cttagtgata    23460

tcacagaagc ctctccctag tgcctgcgta tggactaaaa tattcacagg agcaacttcc    23520

cagaaccaag agccccccag aacatttccc acaggccaca gggtcctctg agtggcctaa    23580

ggtggtcaaa ttctgacacc tggggctgga ctcaggggat aaaaaggact gtcaggctgc    23640

tggccagcca tggggtccag tcccgctgtg ggcaggaagg actctgctcc tccccccaca    23700

cctcaggcac gtcagagaga agaggcatcc ctcttgccca cggaggcctc actgcttagc    23760

tcccagcctc aaggtcagat attcacggag ccatgttttc ctagtaagag gggcactgca    23820

ctgagagctg atgcagtttg tgagcccatt tctccactag ggcctggacg ggtaaatcag    23880

gctgatgctg gtctgcccca gacccacaga gagagaactg gaaataggaa gttatgcttg    23940

cctggcctag gtgccggttc taactcagct tgaccagaaa ggccctgtgt tgggagtagc    24000

aagcactgta tcagccatca atcaagtggg tcctggtttc ctgggaggcc atggtccttg    24060

tgtgcctaat ccctgtcaag aaccccagag aggaggaagg aagcacccaa agctgatcac    24120

ctccaacact taccagggta tggcagtggg gtccgggctg agacctgtgt acttggtact    24180

cccctacttg ctgatgtccc tcctctggag gcctcctgac cccagaccct gtgtgcctac    24240

ccatccttgt tgcttcttca gggaaccaca cagactcggc tcagccacgg ggctgcattt    24300

ctcttcacgt ggaacatttg gccacagctc ccccaagaat gtaaatgtgg tctttataga    24360

gatgaggtcg cagcactcgc tccactctga gcccaggtgc tgccgagtta gtgttggcct    24420

gatgctctgg gcagagctgc cctctcagaa ggggcgccaa gttaaacacc gctaggtact    24480

ctgcactggt ccaaagggag cgctttgccc actgcacgtt gaaaactcag tttcattgac    24540

aaaaaagatt tccattcttc atgtcaatat atctttgtgg ccttctccac tgaaattctg    24600

acttaaaaat acatggaaaa catctactgg taaatatctt acatttagtc ttgtattgaa    24660

aagcaaatat agtaacgtgt gtggaggagg aattagttgg gggggtgaac aacttcaaaa    24720

atgtcagctt tcatctatca aaggaaacag aaagggataa tcttcacaga gcacctgccc    24780

cagctggctc ccatgctggc cgctcttggg ttcatgacat cctcagaata gctatggtct    24840

cttcccattt cacagaagaa gaaattgagg ctcaatgagg acactgccca aagtcacact    24900

gtgcataggt gaggccatcg agattggagc caagggctcc tgactccaag tgtggagtct    24960

ccctccagcc ctcgcttcct cagccaggtc ttcctccatc gaggccagac ccttgcctgg    25020

ccccctacga gggcattatt tatatggaac agctatagat ttttcacagt attatttata    25080

tgttacagtt gtggatttct catcaaagta ggatgttttg tctctgctat tttaaaggag    25140

ccacataatt ttactgctga caatttttca atgttaactc tttttctgac taattttcat    25200

ccatcagtga tgtttctgac ctttgccact ggtgccttta atgtgtgaaa aggaaatgtg    25260

tttgaatgca ggagatttca cagaggtcta ctaagggttc taagggaaat tgtgtttgaa    25320

tttgtgtttt tgatggaagc taatggggcc tgattgtcat gtgaaattcc gtgtacagac    25380

acatatgcac attttttgta acagcagaaa atactaaaca tttctacaca atttgatacc    25440

tactcgatta ttctagaaag ccttaaaaga attaccccgt ttgccttttt taaaaaaaga    25500

aaaacttctt ctacatcata acagacacta caatcgttga aaaatgggca aagaacacca    25560

aaaggtaaat acggaagaaa aaaatcatta aagattttta aaagttttac acctcgacaa    25620

agaactgtaa atttttatgt tttatttttt tcgctggctg actggcaaag attaacatta    25680

gttctaagga cacagagcta agtcagcatg gatccctcat tcttgagttc gttctggttg    25740

ggggaaaaga agtagtgtgt gagctctgca caccccctgg gtgcatacac ctgctgtgtc    25800

ctttacccac caggtaacct tgaggggctc ctctaatgac cacagggtct gctttcctac    25860

ctcacaggag tgtcaggagg gtcacctgtg gaaatacgtg gctaggacca taggaaatgc    25920

tcagtacaca ctggctatta ttattactac ttcagtcact actcttagag caaggagttt    25980

ataacctggg actttgggaa tccattacct tctgaaactg tatacagaat tgtgtgagtc    26040

tgtgcatttt tctgaataaa ggatctagaa ccatccccaa attcttaaag ggactagtag    26100

ccccaaaaca tttaaaaaca cttgccttta aaaagagccc ttggtggaaa tgccaaaggt    26160

aaaactgaga tcattcatgg cgcccacaaa ggcagcccca gctggagcca cgaggccaac    26220

tgccactctc ccagcagcct ccacagcctc tccctacgtg gcgcctcctt caaaggcagc    26280

ctttacctct gacaattctg cagcagtcct ggcagctgtg cagtaagagg ctgggctgct    26340

cgctctcagt gggcgttatt ttgcaggctt ctgccggatc ttccgtcacc agcattcaca    26400

tcgaacggcc tctcctgtgc tgctgacttg gtaaggagct gggaggcctc ccacgcccac    26460

cggcgctctg ctccagctgt tggggacaga ctcccattct ctgcctccat ccctggggct    26520

tcagctaaac acaaccaaaa cctttttctc cttcacaaat gctctttctg gaggtctagc    26580

ctccccttcc ctgggaagga tactgaggga gtggtggggg aaaggcagga agtggcactg    26640

gcaaaggaag cagctgcttg tgccccatct gctaccctgg ggtggggagc attgggtcct    26700

gccccatccc ttagagaaga ggcctggcaa aaaggtaaat gggtgagaag atccttcctc    26760

cccagaagat gaagggagaa gcccctgagt taagtgtcag cacccaaacc aatctttctt    26820

atcggggcaa tactgggcag tgggaagcaa ggaatgagca agacagcccc tgccttcccg    26880

tcaggttcta ggtggatgaa tgctcaaaca caaggcttct tcctcaggaa cagcccacct    26940

gagatgtcta acagagacca gaaacctaaa tctttctggt ttataactat tacgtgtgaa    27000

ctagttgagc ccaaacacca gccaggaagg aatctgagaa gtgtgacctg taccagaaaa    27060

gctgagtata cctgtcactg atgggcacct cccttcaact cacacagaaa gagaaaggac    27120

aggagtctac aggaattcaa gtggggagga ggtagtgagg tcagctcctc ccttgcaggg    27180

cgtcagagcg gccccaccct gccctgagct tccgctgccc agcaccgcat ctgcagaggc    27240

tgggactcaa tacacagttg ttgaataaac atacaaattg atagaaaaca tacaatggta    27300

ctttcttagc acttttgtcc ttaaccagtc tcattgtggg gatttttatt tatttatttt    27360

tttgagacgg agtcttgtct tgctctgcca ctcaggctgg agtgcagtgg ggccatctca    27420

gctcactgca acctccacct cctggattca agggattctc ctgcctcacc ctcccgggta    27480

gctgggatca caggtgcgtg ccaccacaca cggctaattt tttgtatttt tagtagagac    27540

agggtttcac catgttagcc aggatggtct cgatctcctg actttgtgat ctgcctgcct    27600

cagcctccca aagtgctggg attacaggcg tgagccaccg tgcccggccc tatgaggaat    27660

attttgaaga gactgaagca aaatgtgatt ttctttcttt cagccatttt catctgaatg    27720

gctaggcctt gaccttctaa agcttcctca gatcaatgag aaaggcccca gcctgtccag    27780

acccttggtg actcaagttt gtaccttctt gctgatgtga ccaacaatgg aacataagaa    27840

actgcctggg gagggcagag ttgatgggca ggggtgggga gggctaaaag accagtggta    27900

taacacccat tccttctgac tgggctgccc aagctcagtg cagtcacaaa gaatcacaga    27960

accctctggt ctcagtttca gaagagagcc atggattggg ctgtatcctg gacatcatcc    28020

tttaagttta tgagcctgca aggaggacct cagaatgcgt gagtgccaag catctggccc    28080

tcactgagct tcctttggaa aacacacaga ttcagctgaa agggaacctg gccccctaaa    28140

aacacacttg aagagcagtg aatgaattgc agaaatatcc caaagtctct ggctacatgg    28200

ccaaattctg ggcatggcct aggcccctgt gactgtggaa gttcatttag taaaagctgc    28260

agcagtcatc acgaagcact gtcactggaa gggcagacgt ggagtcagaa ttgaagggtg    28320

ccaactgtac ttggccccca gaaacagtaa tccagtggaa ctgagtttcc ttgcagaagc    28380

aaagccatca gagcctgcag gcactgactg atgttgccac gtttagtagg tccacatctc    28440

tttttcctaa tataatgaac acgaaaaaga tcactccagc aacttccccc aaatgatctc    28500

agtaatcctg acaacactat atgagggaaa tctgatcttc cttctacaat cagaagaaac    28560

tgggggctgg gagaatgaag aagtctgcca aaagtcaaac tgtgaggcgg gtgagaggag    28620

aaagtgagct tggagtatgg gcatcctgac ccctggtccg aggctcttgt ctttataatt    28680

acttattaaa ctcgcaaaac aaaaattggt tacctcagac cgtgggcctg tggctcccag    28740

ctggagcctc aacagaggtt gtgcctgctt ggggtgcagc tgggggtgcg gcctggtgac    28800

aggcaggtct gtgatgtata tgcatgtctg tgtccccagg cccatggaga gactgcctgc    28860

aggccctgga ggatggccac gacaccagct ccatctacct ggtgaagccg gagaacacca    28920

accgcctcat gcaggtgtgg tgcgaccaga gacacgaccc cgggggctgg accgtcatcc    28980

agagacgcct ggatggctct gttaacttct tcaggaactg ggagacgtac aaggtgagac    29040

tcggcagggg atgtctgtgc tgcccacaag gtgactggcc caccccaaga gaggcctgag    29100

caaccaatag aagagcccac tcagaggtac atgctgacca agcccaggcc tgtgcggccc    29160

caacaacaca tatacctgag gcgagaagga tgcagacagg gccattttgc aaacccacca    29220

ggggtagtga ggaccagcgc ctcctctgcc tgctgctaga aactgctgca ggacaagagt    29280

cagtagacca gaccaccaca gccccacagg acagggtgag agtttagaaa cgctggtatg    29340

ggggcccagg ggtgaggagc atttcactcc caagtggggt ttccatgggg aaagacccgc    29400

tctcaaagcc cagaaggcgc aagtcccaag aggctcccag ttcctgggag aatcccccaa    29460

aaagtcctgg tagggagttg tggcaatgct caagtcctaa ttccaggctc atcctctggg    29520

ctccctggtt cccagggagt tgaaatgctc atctgtgtag cagggaaagt tgccaggact    29580

cagtcataca tcgttcttcc ccctctaaac agaggtagta ctaaggaagg caagagtggc    29640

tctgtttgct gagtgcccaa cccgtgccag caccatgcta agggctttcg tgcattattt    29700

tgtttaatct cgtatcaacc tcctgaggga ggttctgtta tggacccagc ttacagatga    29760

aagtgtggag taatttgctc agggttgcaa agccaggaat tggcccagta gtgactgcag    29820

ctgaggcctc tgacactgaa gctcacaaac tacctgaagc catgatgcct tgcacacatg    29880

gctctgccat gccccttctt gagtctcctg tcctggttgt cccccacccc acctcctgaa    29940

cagcctgtgt ctctgctttt ttctcctctt ccacctacat taggagcggg agactcctcc    30000

tttcttagag gcaatacagt gcaatgatta agactgggtt cttggttcaa atcctggttc    30060

accctcaggc attctgagac cctgagcctc tctgggcctc agttcatcca tactagggag    30120

gataatgata gcacttagtt cttcgagttg acatgaggat tagtaaaaca acctatgtaa    30180

agttcttaaa acagtgccag cacatcacaa gcgctcaata ctaaataatt attgtattaa    30240

tgaatcaccg attcccaaga ctttagtggc cgtaactcag ctgctgaccc caaaaccaca    30300

tgcaaaaaaa aacaataacc acaaaaccac tgggttttag acctagaggg gagcgccggt    30360

ggatgggaca catgcgtcac agctcacacc cgtctggtgc gttacagctt acacgtgacc    30420

ctcacacaca gctcatctcc agagaaggag gtgaagctca gtgaaggtca gagatttgtc    30480

tgaggaatgc ctgctgcgtg cctacttagt gccaggccct ccacctgcca cagcacacgt    30540

gttcctgcag caagcctgtg gggaaggtaa tatagcctcc ctgatgtaag aacaaggaat    30600

ctggggttca catgatgcct ggcacagggt aggcactcta catatttttg aataatgtgt    30660

gagtcatgga gagattaaga ggtggagtag gggtctgaac caggtctgct tcatgctctg    30720

cttgtttccc aggcccctct atccagggct gagtgtctga cagccaagcc tgctggctgc    30780

aggtgctgca ggctccacat taacactctc ctgggttttc cccagcaagg gtttgggaac    30840

attgacggcg aatactggct gggcctggag aacatttact ggctgacgaa ccaaggcaac    30900

tacaaactcc tggtgaccat ggaggactgg tccggccgca aagtctttgc agaatacgcc    30960

agtttccgcc tggaacctga gagcgagtat tataagctgc ggctggggcg ctaccatggc    31020

aatgcgggtg actcctttac atggcacaac ggcaagcagt tcaccaccct ggacagagat    31080

catgatgtct acacaggtag gaaaagtgga gtcaaaccca ggtgcagggt agggaaaaga    31140

ggtcaaccag agccagagcc cctgactcca gggcttggaa acgggaagat cccagggtga    31200

gaagcagctg ggccaagctg cctgaccctg ttaccacccc ctgagggtcc cttctcctgc    31260

ccacaggtcc ccttcacaaa gctgggtcac agtggcattt acaaattaag aaaaaaaaaa    31320

tgggatgggg cgagacataa agaggtatac aaatcacacg taccagggcc agctggggcc    31380

aatgcagaaa gacatgtgtt gggctgtggc ctcaccactt ctgtcccagg cacctggtat    31440

agagctaacc aactgcgtag gctctgggcc acacacctgg gctccagtgc tggccccacc    31500

tcctaccagc catgtgtcct tgggcatact gctaaatctc cgtgggtctc agtttctgca    31560

tctggaagta aggacaagaa ctacattgca gagtagggag aagggtagag agaatgtacc    31620

taaagtgctt tgtctaggat ttggcacata gcgagggctc catacaaact ggctttcttc    31680

atggtcactg ttactgcatg taatgctagt gcagtgctga gaggaagcta ttaagaggaa    31740

agcagatagg agagagaaag tgatttgtct aagatcacat gcttcaaatc taggtcttta    31800

ctaagaagtc tttattaaac aaaaaacaag agaaaaaaac agaaaatcag aagaaacaga    31860

gatatggtct ggccctgagt ccagatatca gcctcccaca cagttaatgc ctccccaggg    31920

ccaacaccca gtttcttgag atgaaggcct ctcagtctgc catgctcctc cctgaggctg    31980

gcaccacctg acggccgatg ctgcctccag gctcaggctg tctgctctca agggcaaacc    32040

cagtcccctc ctgcctccat ttcctatgtg gtcttggtca gaaggctact ccctcccact    32100

tgagaagcga gctctcaaga ctgtcctaca aatggcctgt acttcaggca ggccctggaa    32160

cctacatact aaggtggagg ggatcctcat gccaggtccc catagcagcc acattctgaa    32220

gggtaattct cccaacatca ggggacagga gggacatgac ctgcccatcc ctgtatcaca    32280

cagacacctc tgtccgccca ctgacactga actggcctgg cccgaagggg ccctggaaga    32340

ggaacaggcc ctcattctga agcagtaggg gctgccgagg cttctagaag agcagggcag    32400

aaggataacc ttcagagctg gtcagaccct gggacacagg ggctgctaca gcctttctgg    32460

agggccacct ccttagggag cggaaagtgt attctatgat ccaaactcag atctagccag    32520

cagcaaaatc agtagctggc aaggtccttg tccctggagg tgtgtgggac ctccgctggc    32580

aaagaggagg ctggttatgg cgtgcccaag gatctccctg ctataccagt ccaacactgc    32640

cacttggtcc ctgtggcctg gaatcatggc ccagagggac ccccagaaaa actctgggaa    32700

aacctggctc cacctcccct cttgctttct gcctcagact gagtgcgacc tcctcacctc    32760

atcccacggc ctcggccacc tgctctgttg ggccctccaa cccacaattc tgactggagc    32820

agcccctccc ctgagtacgg ggtccccttg ccaggcccag tcaggaaagt ggggaccccc    32880

cttcactaag agcaatgctg gcagatagtg gccccctgtc ctcctgccac agagtgcact    32940

gcccctgcat gcccgcgcac accttcccac agtttttact gttgttctga actgcttgtc    33000

cttggcagca aaattcagca tgatgtgata atgccaagag ttttatggaa atatctttcc    33060

tttgtgaagt aatacaaaaa attgtttgga tggaatacaa gctggggagg actggaggag    33120

catttcttct taaacacttt ctttgtcatt ctttaaagac tcctgatcca acagtttcaa    33180

ctcaaaaatt cctaagaaaa agcttttctc cctccccgcc cacctcaggc catctccatt    33240

tcctatcaga acacaaggtg tggagttccc ttggggcctc ctttgcaccc agccctgggc    33300

taggtgtcaa gtacgcatcc tcattcaatc ctcagagccg ccctgtgcgg caggcgtcat    33360

ttttattctc attttacaga tgaggataca gtggctggga gaggtcaagt cacttgtctg    33420

agatcacaca gctagttagt tacaaagctg agcctcaaag gcgggcctga agcatggcct    33480

ctcaccaccc atggagacgg gtccaccttt caagcgttct tgctccagat gcctcccaga    33540

gagggctttg ccgaaagccc tgagcactat ggacgcaagt agaatggcct cctcccagac    33600

accctctcac tgccttctct cttgcaggaa actgtgccca ctaccagaag ggaggctggt    33660

ggtataacgc ctgtgcccac tccaacctca acggggtctg gtaccgcggg ggccattacc    33720

ggagccgcta ccaggacgga gtctactggg ctgagttccg aggaggctct tactcactca    33780

agaaagtggt gatgatgatc cgaccgaacc ccaacacctt ccactaagcc agctccccct    33840

cctgacctct cgtggccatt gccaggagcc caccctggtc acgctggcca cagcacaaag    33900

aacaactcct caccagttca tcctgaggct gggaggaccg ggatgctgga ttctgttttc    33960

cgaagtcact gcagcggatg atggaactga atcgatacgg tgttttctgt ccctcctact    34020

ttccttcaca ccagacagcc cctcatgtct ccaggacagg acaggactac agacaactct    34080

ttctttaaat aaattaagtc tctacaataa aaacacaact gcaaagtacc ttcataatat    34140

acatgtgtat gagcctccct tgtgcacgta tgtgtatacc acatatatat gcatttagat    34200

atacatcaca tgtgatatat ctagatccat atataggttt gccttagata cctaaataca    34260

catatattca gttctcagat gttgaagctg tcaccagcag ctttgctctt aggagaaaag    34320

catttcatta gtgttgtatt acttgagtct aagggtagat cacagactgt gtggtctcaa    34380

ctgaaaggat cacccttggc atctgtgtgc ctggattctt ccagaatgtc tacaatgcta    34440

atctctcaca tagaggttcc cagcttctta agaacccctt ttggcaccta atcaaatttc    34500

aaaatccctc cccccacatt ttcatacttt tccccattct caggactttt caccatccat    34560

cacccactta tcccttcatt tgacaccatt cattaagtgc cttctgtgtg tcagtccctg    34620

gccactcact gcagttcaag gccccctttc cgctctgctg tactcctcgc ctacctactc    34680

cttgcctttt ctgtcgcaca gccccttctt tccaggcgag attcctcagc ttctgagtag    34740

gaaacactcc gggctccagg tttctggttg ggaagggaag gccaggccaa aagctccacc    34800

ggccgtatag ataatgtact cgcagttttg tatcttccat tcatacttta acctacaggt    34860

catttgagtc ttcacacaaa taataaccta tctggccagg agaattatct cagaacagaa    34920

gtcatcagat catcagagcc cccagatggc tacagaccag agattccacg ctctcaggct    34980

gactagagtc cgcatctcat ctccaaacta cacttccctg gagaacaagt gccacaaaaa    35040

tgaaaacagg ccacttctca ggagttgaat aatcaggggt caccggaccc cttggttgat    35100

gcactgcagc atggtggctt tctgagtcct gttggccacc aagtgtcagc ctcagcactc    35160

ccgggactat tgccaagaag gggcaaggga tgagtcaaga aggtgagacc cttcccggtg    35220

ggcacgtggg ccaggctgtg tgagatgttg gatgtttggt actgtccatg tctgggtgtg    35280

tgcctattac ctcagcattt ctcacaaagt gtaccatgta gcatgttttg tgtatataaa    35340

agggagggtt tttttaaaaa tatattccca gattatcctt gtaatgacac gaatctgcaa    35400

taaaagccat cagtgct                                                   35417


<210>  2
<211>  3572
<212>  DNA
<213>  Homo Sapiens

<400>  2
gcctttctgg ggcctggggg atcctcttgc actggtgggt ggagagaagc gcctgcagcc       60

aaccagggtc aggctgtgct cacagtttcc tctggcggca tgtaaaggct ccacaaagga      120

gttgggagtt caaatgaggc tgctgcggac ggcctgagga tggaccccaa gccctggacc      180

tgccgagcgt ggcactgagg cagcggctga cgctactgtg agggaaagaa ggttgtgagc      240

agccccgcag gacccctggc cagccctggc cccagcctct gccggagccc tctgtggagg      300

cagagccagt ggagcccagt gaggcagggc tgcttggcag ccaccggcct gcaactcagg      360

aacccctcca gaggccatgg acaggctgcc ccgctgacgg ccagggtgaa gcatgtgagg      420

agccgccccg gagccaagca ggagggaaga ggctttcata gattctattc acaaagaata      480

accaccattt tgcaaggacc atgaggccac tgtgcgtgac atgctggtgg ctcggactgc      540

tggctgccat gggagctgtt gcaggccagg aggacggttt tgagggcact gaggagggct      600

cgccaagaga gttcatttac ctaaacaggt acaagcgggc gggcgagtcc caggacaagt      660

gcacctacac cttcattgtg ccccagcagc gggtcacggg tgccatctgc gtcaactcca      720

aggagcctga ggtgcttctg gagaaccgag tgcataagca ggagctagag ctgctcaaca      780

atgagctgct caagcagaag cggcagatcg agacgctgca gcagctggtg gaggtggacg      840

gcggcattgt gagcgaggtg aagctgctgc gcaaggagag ccgcaacatg aactcgcggg      900

tcacgcagct ctacatgcag ctcctgcacg agatcatccg caagcgggac aacgcgttgg      960

agctctccca gctggagaac aggatcctga accagacagc cgacatgctg cagctggcca     1020

gcaagtacaa ggacctggag cacaagtacc agcacctggc cacactggcc cacaaccaat     1080

cagagatcat cgcgcagctt gaggagcact gccagagggt gccctcggcc aggcccgtcc     1140

cccagccacc ccccgctgcc ccgccccggg tctaccaacc acccacctac aaccgcatca     1200

tcaaccagat ctctaccaac gagatccaga gtgaccagaa cctgaaggtg ctgccacccc     1260

ctctgcccac tatgcccact ctcaccagcc tcccatcttc caccgacaag ccgtcgggcc     1320

catggagaga ctgcctgcag gccctggagg atggccacga caccagctcc atctacctgg     1380

tgaagccgga gaacaccaac cgcctcatgc aggtgtggtg cgaccagaga cacgaccccg     1440

ggggctggac cgtcatccag agacgcctgg atggctctgt taacttcttc aggaactggg     1500

agacgtacaa gcaagggttt gggaacattg acggcgaata ctggctgggc ctggagaaca     1560

tttactggct gacgaaccaa ggcaactaca aactcctggt gaccatggag gactggtccg     1620

gccgcaaagt ctttgcagaa tacgccagtt tccgcctgga acctgagagc gagtattata     1680

agctgcggct ggggcgctac catggcaatg cgggtgactc ctttacatgg cacaacggca     1740

agcagttcac caccctggac agagatcatg atgtctacac aggaaactgt gcccactacc     1800

agaagggagg ctggtggtat aacgcctgtg cccactccaa cctcaacggg gtctggtacc     1860

gcgggggcca ttaccggagc cgctaccagg acggagtcta ctgggctgag ttccgaggag     1920

gctcttactc actcaagaaa gtggtgatga tgatccgacc gaaccccaac accttccact     1980

aagccagctc cccctcctga cctctcgtgg ccattgccag gagcccaccc tggtcacgct     2040

ggccacagca caaagaacaa ctcctcacca gttcatcctg aggctgggag gaccgggatg     2100

ctggattctg ttttccgaag tcactgcagc ggatgatgga actgaatcga tacggtgttt     2160

tctgtccctc ctactttcct tcacaccaga cagcccctca tgtctccagg acaggacagg     2220

actacagaca actctttctt taaataaatt aagtctctac aataaaaaca caactgcaaa     2280

gtaccttcat aatatacatg tgtatgagcc tcccttgtgc acgtatgtgt ataccacata     2340

tatatgcatt tagatataca tcacatgtga tatatctaga tccatatata ggtttgcctt     2400

agatacctaa atacacatat attcagttct cagatgttga agctgtcacc agcagctttg     2460

ctcttaggag aaaagcattt cattagtgtt gtattacttg agtctaaggg tagatcacag     2520

actgtgtggt ctcaactgaa aggatcaccc ttggcatctg tgtgcctgga ttcttccaga     2580

atgtctacaa tgctaatctc tcacatagag gttcccagct tcttaagaac cccttttggc     2640

acctaatcaa atttcaaaat ccctcccccc acattttcat acttttcccc attctcagga     2700

cttttcacca tccatcaccc acttatccct tcatttgaca ccattcatta agtgccttct     2760

gtgtgtcagt ccctggccac tcactgcagt tcaaggcccc ctttccgctc tgctgtactc     2820

ctcgcctacc tactccttgc cttttctgtc gcacagcccc ttctttccag gcgagattcc     2880

tcagcttctg agtaggaaac actccgggct ccaggtttct ggttgggaag ggaaggccag     2940

gccaaaagct ccaccggccg tatagataat gtactcgcag ttttgtatct tccattcata     3000

ctttaaccta caggtcattt gagtcttcac acaaataata acctatctgg ccaggagaat     3060

tatctcagaa cagaagtcat cagatcatca gagcccccag atggctacag accagagatt     3120

ccacgctctc aggctgacta gagtccgcat ctcatctcca aactacactt ccctggagaa     3180

caagtgccac aaaaatgaaa acaggccact tctcaggagt tgaataatca ggggtcaccg     3240

gaccccttgg ttgatgcact gcagcatggt ggctttctga gtcctgttgg ccaccaagtg     3300

tcagcctcag cactcccggg actattgcca agaaggggca agggatgagt caagaaggtg     3360

agacccttcc cggtgggcac gtgggccagg ctgtgtgaga tgttggatgt ttggtactgt     3420

ccatgtctgg gtgtgtgcct attacctcag catttctcac aaagtgtacc atgtagcatg     3480

ttttgtgtat ataaaaggga gggttttttt aaaaatatat tcccagatta tccttgtaat     3540

gacacgaatc tgcaataaaa gccatcagtg ct                                   3572


<210>  3
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0001

<400>  4
ttacatgccg ccagaggaa                                                    19


<210>  5
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0190

<400>  5
gagcctttac atgccg                                                       16


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0095

<400>  6
atagcaggga gtgacc                                                       16


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0189

<400>  7
gaaatgttat ctaatact                                                     18


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0094

<400>  8
tgtttggaaa tgttatct                                                     18


<210>  9
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0188

<400>  9
gctctcataa tcctac                                                       16


<210>  10
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0093

<400>  10
ttctcctaga aagcagt                                                      17


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0187

<400>  11
acagggaaag aatttgggtc                                                   20


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0092

<400>  12
atcaataggc agacaggc                                                     18


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0186

<400>  13
atgaagtcag tcagagcct                                                    19


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AASO-0091

<400>  14
agtgagagga agtcaggg                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0185

<400>  15
tgatgtggtg agacagta                                                     18


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0090

<400>  16
atttactgtc tgcccag                                                      17


<210>  17
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0184

<400>  17
gtcatagaaa ctacccc                                                      17


<210>  18
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0089

<400>  18
ccacacccaa catttta                                                      17


<210>  19
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0183

<400>  19
tggacaacta ggcagca                                                      17


<210>  20
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0088

<400>  20
acagagacta ggcattt                                                      17


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0182

<400>  21
acacccaaga ctcagat                                                      17


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0087

<400>  22
aggggctatg actatcc                                                      17


<210>  23
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0181

<400>  23
ctagtgtgct ctggagc                                                      17


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0086

<400>  24
attttgagat tcccccaaag                                                   20


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0180

<400>  25
ttgagattcc cccaaag                                                      17


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0085

<400>  26
attttgagat tcccccaaa                                                    19


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0179

<400>  27
ttttgagatt cccccaaa                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0084

<400>  28
attttgagat tcccccaa                                                     18


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0178

<400>  29
ccattttgag attcccccaa                                                   20


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0083

<400>  30
cattttgaga ttccccca                                                     18


<210>  31
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0177

<400>  31
cattttgaga ttccccc                                                      17


<210>  32
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0081

<400>  32
ccattttgag attcccc                                                      17


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0082

<400>  33
aaccattttg agattcccc                                                    19


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0176

<400>  34
accattttga gattcccc                                                     18


<210>  35
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0080

<400>  35
accattttga gattccc                                                      17


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0174

<400>  36
gaaccatttt gagattccc                                                    19


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0175

<400>  37
aaccattttg agattccc                                                     18


<210>  38
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0079

<400>  38
aaccattttg agattcc                                                      17


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0173

<400>  39
gaaccatttt gagattcc                                                     18


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0078

<400>  40
ccacccattt agccttc                                                      17


<210>  41
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0172

<400>  41
taatggctga gatgcag                                                      17


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0077

<400>  42
ccttttcact ctcaatat                                                     18


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0171

<400>  43
aagctgttga aatgtatg                                                     18


<210>  44
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0076

<400>  44
ctccaaatta aatccg                                                       16


<210>  45
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0170

<400>  45
acaactcaca ttcatag                                                      17


<210>  46
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0075

<400>  46
gtattgtgag gagtttc                                                      17


<210>  47
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0169

<400>  47
cttaatgggc agtaata                                                      17


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0074

<400>  48
gttatgccca tttctagg                                                     18


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0168

<400>  49
ctatcctctc ccaaacatg                                                    19


<210>  50
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0073

<400>  50
cagaacaatg gggagga                                                      17


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0167

<400>  51
tattagcatc actacttt                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0072

<400>  52
gctggaaaga gggataga                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0166

<400>  53
tccaaggcac tctatgat                                                     18


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0071

<400>  54
taattcaccg ccaaattac                                                    19


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0165

<400>  55
gaattttctt taccttag                                                     18


<210>  56
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0070

<400>  56
caagagggag gggaggaca                                                    19


<210>  57
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0164

<400>  57
acttctattc ttggacc                                                      17


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0069

<400>  58
agttctgttt gatcttc                                                      17


<210>  59
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0163

<400>  59
ctgggttata ttctctt                                                      17


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0068

<400>  60
atggtggtta ttctttgtga                                                   20


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0162

<400>  61
ccttgcaaaa tggtggtt                                                     18


<210>  62
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0067

<400>  62
tgtaggtgca cttgtc                                                       16


<210>  63
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0161

<400>  63
tgctggggca caatgaa                                                      17


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0066

<400>  64
ttatgcactc ggttctcc                                                     18


<210>  65
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0160

<400>  65
gctcattgtt gagcagc                                                      17


<210>  66
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0065

<400>  66
agctcattgt tgagcag                                                      17


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0159

<400>  67
cagctcattg ttgagcag                                                     18


<210>  68
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0064

<400>  68
cagctcattg ttgagca                                                      17


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0158

<400>  69
gcagctcatt gttgagca                                                     18


<210>  70
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0063

<400>  70
gcagctcatt gttgagc                                                      17


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0157

<400>  71
gagttcatgt tgcggc                                                       16


<210>  72
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0062

<400>  72
gcttgcggat gatctc                                                       16


<210>  73
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0156

<400>  73
caggtccttg tacttgc                                                      17


<210>  74
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0061

<400>  74
caggtgctgg tacttgtg                                                     18


<210>  75
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0155

<400>  75
cggttgtagg tgggtgg                                                      17


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0058

<400>  76
ttgatgatgc ggttgtaggt                                                   20


<210>  77
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0059

<400>  77
tgatgatgcg gttgtaggt                                                    19


<210>  78
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0060

<400>  78
atgatgcggt tgtaggt                                                      17


<210>  79
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0153

<400>  79
tgatgcggtt gtaggt                                                       16


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0154

<400>  80
gatgatgcgg ttgtaggt                                                     18


<210>  81
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0056

<400>  81
ttgatgatgc ggttgtagg                                                    19


<210>  82
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0057

<400>  82
gatgatgcgg ttgtagg                                                      17


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0151

<400>  83
tgatgatgcg gttgtagg                                                     18


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0152

<400>  84
atgatgcggt tgtagg                                                       16


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0054

<400>  85
ttgatgatgc ggttgtag                                                     18


<210>  86
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0055

<400>  86
gttgatgatg cggttgtag                                                    19


<210>  87
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0149

<400>  87
tgatgatgcg gttgtag                                                      17


<210>  88
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0150

<400>  88
gatgatgcgg ttgtag                                                       16


<210>  89
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0052

<400>  89
ttgatgatgc ggttgta                                                      17


<210>  90
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0053

<400>  90
tgatgatgcg gttgta                                                       16


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0147

<400>  91
tggttgatga tgcggttgta                                                   20


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0148

<400>  92
gttgatgatg cggttgta                                                     18


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0051

<400>  93
tggttgatga tgcggttg                                                     18


<210>  94
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0146

<400>  94
ctggttgatg atgcggttg                                                    19


<210>  95
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0050

<400>  95
tggttgatga tgcggtt                                                      17


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0145

<400>  96
ctggttgatg atgcggtt                                                     18


<210>  97
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0144

<400>  97
atctggttga tgatgcgg                                                     18


<210>  98
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0049

<400>  98
atagtgggca gaggggg                                                      17


<210>  99
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0143

<400>  99
tgggcatagt gggcaga                                                      17


<210>  100
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0048

<400>  100
catctaagga atgtggt                                                      17


<210>  101
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0142

<400>  101
aagcatcatt gaaaattc                                                     18


<210>  102
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0047

<400>  102
agatgaatat agttctc                                                      17


<210>  103
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0141

<400>  103
ccagagctaa tcagtgg                                                      17


<210>  104
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0046

<400>  104
ccaagggcac gtttta                                                       16


<210>  105
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0140

<400>  105
acataatgtt tcatgct                                                      17


<210>  106
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0045

<400>  106
cctggtaaaa tcttaca                                                      17


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0139

<400>  107
tcagtggtga gatgggtcac                                                   20


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0044

<400>  108
agctcagtgg tgagatgg                                                     18


<210>  109
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0138

<400>  109
ctaggcactc aatccca                                                      17


<210>  110
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0043

<400>  110
gaagaaaaga gcacatgg                                                     18


<210>  111
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0137

<400>  111
gtttctgaca aagcccg                                                      17


<210>  112
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0042

<400>  112
gaacctcaat atcctgc                                                      17


<210>  113
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0136

<400>  113
aaccccagag gatatgt                                                      17


<210>  114
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0041

<400>  114
ttatagggtg gaataaa                                                      17


<210>  115
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0135

<400>  115
atcttatttt gtttaaca                                                     18


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0039

<400>  116
gttgatagtt tatctcct                                                     18


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0040

<400>  117
aagttgatag tttatctcct                                                   20


<210>  118
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0134

<400>  118
agttgatagt ttatctcct                                                    19


<210>  119
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0038

<400>  119
agttgatagt ttatctcc                                                     18


<210>  120
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0132

<400>  120
gttgatagtt tatctcc                                                      17


<210>  121
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0133

<400>  121
aagttgatag tttatctcc                                                    19


<210>  122
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0037

<400>  122
aagttgatag tttatctc                                                     18


<210>  123
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0131

<400>  123
ctagatttct ttcagtttg                                                    19


<210>  124
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0036

<400>  124
tagtaggaaa gatcatct                                                     18


<210>  125
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0130

<400>  125
ctagacatac catcta                                                       16


<210>  126
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0034

<400>  126
accctccatc cttcacc                                                      17


<210>  127
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0035

<400>  127
accctccatc cttcacc                                                      17


<210>  128
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0129

<400>  128
accctccatc cttcacc                                                      17


<210>  129
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0128

<400>  129
gcagttatca caccaca                                                      17


<210>  130
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0033

<400>  130
acaagccagt tgtatgt                                                      17


<210>  131
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0127

<400>  131
caggcacact aatgaga                                                      17


<210>  132
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0032

<400>  132
agttactctt agccaaa                                                      17


<210>  133
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0126

<400>  133
ccaaccataa attaattg                                                     18


<210>  134
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0031

<400>  134
caaaggcatt tcagttcc                                                     18


<210>  135
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0125

<400>  135
gactaactgt tgaaattg                                                     18


<210>  136
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0030

<400>  136
gtgggcaaga gggatgc                                                      17


<210>  137
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0124

<400>  137
ttgacaggga ttaggca                                                      17


<210>  138
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0029

<400>  138
ccaacactaa ctcggc                                                       16


<210>  139
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0123

<400>  139
gccaacacta actcggc                                                      17


<210>  140
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0028

<400>  140
caggccaaca ctaactcgg                                                    19


<210>  141
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0027

<400>  141
caggccaaca ctaactcg                                                     18


<210>  142
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0122

<400>  142
aggccaacac taactcg                                                      17


<210>  143
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0121

<400>  143
caggccaaca ctaactc                                                      17


<210>  144
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0026

<400>  144
gtgctctgtg aagatta                                                      17


<210>  145
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0120

<400>  145
gcaaaggtca gaaacatc                                                     18


<210>  146
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0025

<400>  146
aatttacagt tctttgtc                                                     18


<210>  147
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0119

<400>  147
ttataaactc cttgctcta                                                    19


<210>  148
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0024

<400>  148
ataacgccca ctgaga                                                       16


<210>  149
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0118

<400>  149
tagcagatgg ggcacaa                                                      17


<210>  150
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0023

<400>  150
gagttgaagg gaggtgc                                                      17


<210>  151
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0117

<400>  151
cccacaatga gactggt                                                      17


<210>  152
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0022

<400>  152
ccaggcagtt tcttatg                                                      17


<210>  153
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0116

<400>  153
actaaatgaa cttccaca                                                     18


<210>  154
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0021

<400>  154
ttataaagac aagagcct                                                     18


<210>  155
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0115

<400>  155
caggcgtctc tggatga                                                      17


<210>  156
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0020

<400>  156
ttaacagagc catccagg                                                     18


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0114

<400>  157
aagaagttaa cagagccatc                                                   20


<210>  158
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0019

<400>  158
ccagttcctg aagaagtta                                                    19


<210>  159
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0113

<400>  159
ccagttcctg aagaagtt                                                     18


<210>  160
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0018

<400>  160
tttctaaact ctcaccctg                                                    19


<210>  161
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0112

<400>  161
aattactcca cactttca                                                     18


<210>  162
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0017

<400>  162
gcattcctca gacaaatc                                                     18


<210>  163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0111

<400>  163
cagccagtaa atgttctcca                                                   20


<210>  164
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0016

<400>  164
gttcgtcagc cagtaa                                                       16


<210>  165
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0110

<400>  165
ttggttcgtc agccag                                                       16


<210>  166
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0015

<400>  166
ccagccgcag cttata                                                       16


<210>  167
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0109

<400>  167
tccagggtgg tgaactg                                                      17


<210>  168
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0014

<400>  168
gtgggcagga gaagggac                                                     18


<210>  169
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0108

<400>  169
gtgccaaatc ctagaca                                                      17


<210>  170
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0013

<400>  170
agtagccttc tgaccaa                                                      17


<210>  171
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0107

<400>  171
gagtttggat catagaa                                                      17


<210>  172
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0012

<400>  172
attgtgggtt ggagggc                                                      17


<210>  173
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0106

<400>  173
agtgtttaag aagaaatg                                                     18


<210>  174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0011

<400>  174
aagagagaag gcagtgagag                                                   20


<210>  175
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0105

<400>  175
tagtgggcac agtttcc                                                      17


<210>  176
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0010

<400>  176
ttctggtagt gggcacag                                                     18


<210>  177
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0009

<400>  177
tccggtaatg gcccc                                                        15


<210>  178
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0104

<400>  178
ctccggtaat ggcccc                                                       16


<210>  179
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0008

<400>  179
gctccggtaa tggccc                                                       16


<210>  180
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0103

<400>  180
ctccggtaat ggccc                                                        15


<210>  181
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0102

<400>  181
gaactcagcc cagtagac                                                     18


<210>  182
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0007

<400>  182
gaactcagcc cagtaga                                                      17


<210>  183
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0101

<400>  183
ttagtggaag gtgttgg                                                      17


<210>  184
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO -0006

<400>  184
actggtgagg agttgtt                                                      17


<210>  185
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0100

<400>  185
tgaaggaaag taggaggga                                                    19


<210>  186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0005

<400>  186
acatgtatat tatgaaggta                                                   20


<210>  187
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0099

<400>  187
tctcctaaga gcaaagct                                                     18


<210>  188
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0004

<400>  188
gtaggtaggc gaggag                                                       16


<210>  189
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0098

<400>  189
ctggaaagaa ggggctgtg                                                    19


<210>  190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0003

<400>  190
tgaatggaag atacaaaact                                                   20


<210>  191
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0097

<400>  191
gttctccagg gaagtgta                                                     18


<210>  192
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0002

<400>  192
tgacccctga ttattca                                                      17


<210>  193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO-0096

<400>  193
taataggcac acacccagac                                                   20


<210>  194
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 Isomer X1 protein sequence

<400>  194

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Leu 
        


<210>  195
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 Isomer 2 protein sequence

<400>  195

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  196
<211>  3444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 mRNA 1

<400>  196
gtctggagct gaggggaggc ccagagcttt tctggggcct gggggatcct cttgcactgg       60

tgggcggaga gaagtgcctg cagccaacca gggtcaggct gtgctcacag tttcctctgg      120

cggcacgtaa aggctccaca aaggacctgg gagttcaact gaggctgctg ctgtcggcct      180

ggggatggac cccaagccct gagtggtgtt gttggaccca ggacctgcaa gaagcatgca      240

ctaaggcagc tgcggaccac actgtgaggg agagcaggtt gggagcagcc ccggtgacac      300

cagagccagc ctcatcccta ggagcttcag agagcataga ctgctgccag ctgaggccag      360

tgaggcaggg ctgctcggcg gccagtccag cctgagactc gggacctctc ctggaggcca      420

cggccaggct gtgctgctga tggcaccgtg aggcatgtga agcgctgctc cagggccaag      480

caggagagaa gaggctttca gttcataaag accaaccagc acactgcaag gaccatgagg      540

ccactgtgta tgacctactg gtggcttgga ctgctggcca cggtcggagc tgctacaggc      600

ccagaggctg acgttgaggg cacagaggat ggttcacaga gagagtacat ttacctcaac      660

aggtacaagc gggcaggtga gtcccccgac aagtgcacct acactttcat tgtgccccag      720

cagcgggtca caggtgccat ttgtgtcaac tccaaggagc ctgaggtgca cctggagaac      780

cgtgtgcaca agcaggagct ggagctgctc aacaatgagc tgcttaagca gaagcggcag      840

atcgagacgc tgcagcagct ggtagaggta gacggaggca tcgtgagcga ggtgaagctg      900

ctgcgcaagg agagccgcaa catgaactcg agagtcacgc agctgtacat gcaacttcta      960

catgagatca ttcgaaagcg agacaatgcg ctggagctct cccagctgga gaacaggatc     1020

ctgaaccaga cagctgacat gctgcagctg gctagcaagt acaaggacct ggagcacaag     1080

ttccagcacc tggctatgct ggcacacaac caatcagagg tcattgctca gctcgaagag     1140

cactgccaac gcgtacctgc agccaggcct atgccccagc cacccccagc agctccacct     1200

cgggtctacc aaccacccac ctacaaccgc atcatcaacc agatttccac caatgagatc     1260

cagagtgacc agaatctgaa ggtgctgccg ccctccttgc ccaccatgcc tgcccttacc     1320

agtctcccat cttccactga taagccatca ggtccatgga gagactgcct gcaagccctg     1380

gaagatggtc acagcaccag ctccatctac ctggtgaagc ctgagaatac caaccgcctg     1440

atgcaggtgt ggtgtgacca gagacatgac cctggaggtt ggactgtcat ccagagacgc     1500

ctggatggct ctgtcaactt cttcaggaac tgggagacct ataagcaagg gtttgggaac     1560

atcgatggtg agtactggct gggcctggag aacatctact ggctgacgaa ccaaggcaac     1620

tacaaactgc tggtaaccat ggaggactgg tctggccgta aagtctttgc tgagtatgcc     1680

agtttccgac tggagccaga aagcgagtac tataagctgc ggctggggcg ttatcatggc     1740

aatgcaggcg actcctttac ctggcacaac ggcaaacagt ttaccaccct ggacagggac     1800

catgatgtct acacaggaaa ctgtgcccac tatcagaagg gaggatggtg gtataacgcc     1860

tgtgctcact ccaacctcaa tggggtctgg taccgtgggg gccattaccg gagcagatac     1920

caggacgggg tctactgggc tgagttccga ggaggctctt actcactcaa gaaggtggtg     1980

atgatgattc ggcccaaccc caacaccttc cactaagctc tccctgcctg gccactaaca     2040

ccatggccag aagccatccc agccgtgtga cctcagcaca gctcttcgct ggcccacctc     2100

aggctggagg actgtgcttt ccaatgtggc tctgtcagac gatggaaatg aacagtgttc     2160

tctgtcccta ctgcgttctt ttacacctaa cagctccttg tattccagga taggatagaa     2220

ctgcagagtc ttccaatcag ttaagtccct ttaataaaga cacaactgcc aatatcgcca     2280

gatctgacag acatgcacac gagccaccag gtgtatgctc ttagacacac atcacacgtg     2340

ggatgtcgag atacacatat gggtttccac atatacttac cttttcctgc tcagttctca     2400

ggtgctgact ccagcaccat agctttgcgc ttaagacaat gtatgtctca ttgtctaagg     2460

acagaacagg cattgtagcc ctgatttcaa aaacagtcct tggcactgcc tggattttcc     2520

cagaatgtcc tcaagctcat ctctcacata ggggctcctg gccttctctc cttgagcccc     2580

acctcccctc agactgttgc acttcccctc tcaggacggc tcagcatccc tccgtacagt     2640

tacccctcag cctgcacctc ctgtgcctta gtctctggct gctcactgga agtcaagtcc     2700

tcttctccct gctcccctgg cctctccttt tctgccacac agagctttat ttctggcaca     2760

attcgttggc ctctgggcag gaaacagtct gggctcaggt cctggctgag aagggaaggc     2820

caggccagaa gccacagagg cagcggcata gacctgtatt cagttctgca ccttccattc     2880

atactttagc ctccacagaa ttttaacctc tacacaaaca gtaccctgct ttgccagaga     2940

caccccactg gagagaagtc gctgccaata ggttggggtc cccagacagc tgcagatttg     3000

aggtcctgtg ctcatgggga acaatcttca ccctgtcacc aagctacatc tcctcagaag     3060

atgaggccac agaaagaaaa actgactttc catgagttgc catgccatca ggggctcctg     3120

acacactgca gcagggtggc ttcctgagtc ttgtttagag ttaccagatg actgcaatgc     3180

caggggcaac atataagtca agaagttgag accctcccag tgggtgtgtg tgccaggtgt     3240

gtgaggtgtg gggcatttgg tactgtccac atctgggtgc actgccctgt tacctcagca     3300

tttctcccag tgtaccatgt agcatgttct gtgtatatat aaaagggagg ttttgttcgt     3360

ttatgttttt aaaaatatat tgccagacac aaatctgtgt attgtaatga cacaaatctg     3420

caataaaagc catcagtgtt acgt                                            3444


<210>  197
<211>  3524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 mRNA 2

<400>  197
gcccgcccct gtctggagct gaggggaggc ccagagcttt tctggggcct gggggatcct       60

cttgcactgg tgggcggaga gaagtgcctg cagccaacca gggtcaggct gtgctcacag      120

tttcctctgg cggcacgtaa aggctccaca aaggacctgg gagttcaact gaggctgctg      180

ctgtcggcct ggggatggac cccaagccct gagtggtgtt gttggaccca ggacctgcaa      240

gaagcatgca ctaaggcagc tgcggaccac actgtgaggg agagcaggtt gggagcagcc      300

ccggtgacac cagagccagc ctcatcccta ggagcttcag agagcataga ctgctgccag      360

ctgaggccag tgaggcaggg ctgctcggcg gccagtccag cctgagactc gggacctctc      420

ctggaggcca cggccaggct gtgctgctga tggcaccgtg aggcatgtga agcgctgctc      480

cagggccaag caggagagaa gagttcttgg gaactctggt gacatggaag ccctgtgaga      540

gcagccatac ccccaacatc gagctttcag ttcataaaga ccaaccagca cactgcaagg      600

accatgaggc cactgtgtat gacctactgg tggcttggac tgctggccac ggtcggagct      660

gctacaggcc cagaggctga cgttgagggc acagaggatg gttcacagag agagtacatt      720

tacctcaaca ggtacaagcg ggcaggtgag tcccccgaca agtgcaccta cactttcatt      780

gtgccccagc agcgggtcac aggtgccatt tgtgtcaact ccaaggagcc tgaggtgcac      840

ctggagaacc gtgtgcacaa gcaggagctg gagctgctca acaatgagct gcttaagcag      900

aagcggcaga tcgagacgct gcagcagctg gtagaggtag acggaggcat cgtgagcgag      960

gtgaagctgc tgcgcaagga gagccgcaac atgaactcga gagtcacgca gctgtacatg     1020

caacttctac atgagatcat tcgaaagcga gacaatgcgc tggagctctc ccagctggag     1080

aacaggatcc tgaaccagac agctgacatg ctgcagctgg ctagcaagta caaggacctg     1140

gagcacaagt tccagcacct ggctatgctg gcacacaacc aatcagaggt cattgctcag     1200

ctcgaagagc actgccaacg cgtacctgca gccaggccta tgccccagcc acccccagca     1260

gctccacctc gggtctacca accacccacc tacaaccgca tcatcaacca gatttccacc     1320

aatgagatcc agagtgacca gaatctgaag gtgctgccgc cctccttgcc caccatgcct     1380

gcccttacca gtctcccatc ttccactgat aagccatcag gtccatggag agactgcctg     1440

caagccctgg aagatggtca cagcaccagc tccatctacc tggtgaagcc tgagaatacc     1500

aaccgcctga tgcaggtgtg gtgtgaccag agacatgacc ctggaggttg gactgtcatc     1560

cagagacgcc tggatggctc tgtcaacttc ttcaggaact gggagaccta taagcaaggg     1620

tttgggaaca tcgatggtga gtactggctg ggcctggaga acatctactg gctgacgaac     1680

caaggcaact acaaactgct ggtaaccatg gaggactggt ctggccgtaa agtctttgct     1740

gagtatgcca gtttccgact ggagccagaa agcgagtact ataagctgcg gctggggcgt     1800

tatcatggca atgcaggcga ctcctttacc tggcacaacg gcaaacagtt taccaccctg     1860

gacagggacc atgatgtcta cacaggaaac tgtgcccact atcagaaggg aggatggtgg     1920

tataacgcct gtgctcactc caacctcaat ggggtctggt accgtggggg ccattaccgg     1980

agcagatacc aggacggggt ctactgggct gagttccgag gaggctctta ctcactcaag     2040

aaggtggtga tgatgattcg gcccaacccc aacaccttcc actaagctct ccctgcctgg     2100

ccactaacac catggccaga agccatccca gccgtgtgac ctcagcacag ctcttcgctg     2160

gcccacctca ggctggagga ctgtgctttc caatgtggct ctgtcagacg atggaaatga     2220

acagtgttct ctgtccctac tgcgttcttt tacacctaac agctccttgt attccaggat     2280

aggatagaac tgcagagtct tccaatcagt taagtccctt taataaagac acaactgcca     2340

atatcgccag atctgacaga catgcacacg agccaccagg tgtatgctct tagacacaca     2400

tcacacgtgg gatgtcgaga tacacatatg ggtttccaca tatacttacc ttttcctgct     2460

cagttctcag gtgctgactc cagcaccata gctttgcgct taagacaatg tatgtctcat     2520

tgtctaagga cagaacaggc attgtagccc tgatttcaaa aacagtcctt ggcactgcct     2580

ggattttccc agaatgtcct caagctcatc tctcacatag gggctcctgg ccttctctcc     2640

ttgagcccca cctcccctca gactgttgca cttcccctct caggacggct cagcatccct     2700

ccgtacagtt acccctcagc ctgcacctcc tgtgccttag tctctggctg ctcactggaa     2760

gtcaagtcct cttctccctg ctcccctggc ctctcctttt ctgccacaca gagctttatt     2820

tctggcacaa ttcgttggcc tctgggcagg aaacagtctg ggctcaggtc ctggctgaga     2880

agggaaggcc aggccagaag ccacagaggc agcggcatag acctgtattc agttctgcac     2940

cttccattca tactttagcc tccacagaat tttaacctct acacaaacag taccctgctt     3000

tgccagagac accccactgg agagaagtcg ctgccaatag gttggggtcc ccagacagct     3060

gcagatttga ggtcctgtgc tcatggggaa caatcttcac cctgtcacca agctacatct     3120

cctcagaaga tgaggccaca gaaagaaaaa ctgactttcc atgagttgcc atgccatcag     3180

gggctcctga cacactgcag cagggtggct tcctgagtct tgtttagagt taccagatga     3240

ctgcaatgcc aggggcaaca tataagtcaa gaagttgaga ccctcccagt gggtgtgtgt     3300

gccaggtgtg tgaggtgtgg ggcatttggt actgtccaca tctgggtgca ctgccctgtt     3360

acctcagcat ttctcccagt gtaccatgta gcatgttctg tgtatatata aaagggaggt     3420

tttgttcgtt tatgttttta aaaatatatt gccagacaca aatctgtgta ttgtaatgac     3480

acaaatctgc aataaaagcc atcagtgtta cgtggataca ccca                      3524


<210>  198
<211>  1853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 mRNA 3

<400>  198
ccaagccctg agtggtgttg ttggacccag gacctgcaag aagcatgcac taaggcagct       60

gcggaccaca ctgtgaggga gagcaggttg ggagcagccc cggtgacacc agagccagcc      120

tcatccctag gagcttcaga gagcatagac tgctgcctga ggccagtgag gcagggctgc      180

tcggcggcca gtccagcctg agactcggga cctctcctgg aggccacggc caggctgtgc      240

tgctgatggc accgtgaggc atgtgaagcg ctgctccagg gccaagcagg agagaagagg      300

ctttcagttc ataaagacca accagcacac tgcaaggacc atgaggccac tgtgtatgac      360

ctactggtgg cttggactgc tggccacggt cggagctgct acaggcccag aggctgacgt      420

tgagggcaca gaggatggtt cacagagaga gtacatttac ctcaacaggt acaagcgggc      480

aggtgagtcc cccgacaagt gcacctacac tttcattgtg ccccagcagc gggtcacagg      540

tgccatttgt gtcaactcca aggagcctga ggtgcacctg gagaaccgtg tgcacaagca      600

ggagctggag ctgctcaaca atgagctgct taagcagaag cggcagatcg agacgctgca      660

gcagctggta gaggtagacg gaggcatcgt gagcgaggtg aagctgctgc gcaaggagag      720

ccgcaacatg aactcgagag tcacgcagct gtacatgcaa cttctacatg agatcattcg      780

aaagcgagac aatgcgctgg agctctccca gctggagaac aggatcctga accagacagc      840

tgacatgctg cagctggcta gcaagtacaa ggacctggag cacaagttcc agcacctggc      900

tatgctggca cacaaccaat cagaggtcat tgctcagctc gaagagcact gccaacgcgt      960

acctgcagcc aggcctatgc cccagccacc cccagcagct ccacctcggg tctaccaacc     1020

acccacctac aaccgcatca tcaaccagat ttccaccaat gagatccaga gtgaccagaa     1080

tctgaaggtg ctgccgccct ccttgcccac catgcctgcc cttaccagtc tcccatcttc     1140

cactgataag ccatcaggtc catggagaga ctgcctgcaa gccctggaag atggtcacag     1200

caccagctcc atctacctgg tgaagcctga gaataccaac cgcctgatgc aggtgtggtg     1260

tgaccagaga catgaccctg gaggttggac tgtcatccag agacgcctgg atggctctgt     1320

caacttcttc aggaactggg agacctataa gcaagggttt gggaacatcg atggtgagta     1380

ctggctgggc ctggagaaca tctactggct gacgaaccaa ggcaactaca aactgctggt     1440

aaccatggag gactggtctg gccgtaaagt ctttgctgag tatgccagtt tccgactgga     1500

gccagaaagc gagtactata agctgcggct ggggcgttat catggcaatg caggcgactc     1560

ctttacctgg cacaacggca aacagtttac caccctggac agggaccatg atgtctacac     1620

aggaaactgt gcccactatc agaagggagg atggtggtat aacgcctgtg ctcactccaa     1680

cctcaatggg gtctggtacc gtgggggcca ttaccggagc agataccagg acggggtcta     1740

ctgggctgag ttccgaggag gctcttactc actcaagaag gtggtgatga tgattcggcc     1800

caaccccaac accttccact aagctctccc tgcctggcca ctaacaccat ggc            1853


<210>  199
<211>  1853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 mRNA 4

<400>  199
ccaagccctg agtggtgttg ttggacccag gacctgcaag aagcatgcac taaggcagct       60

gcggaccaca ctgtgaggga gagcaggttg ggagcagccc cggtgacacc agagccagcc      120

tcatccctag gagcttcaga gagcatagac tgctgcctga ggccagtgag gcagggctgc      180

tcggcggcca gtccagcctg agactcggga cctctcctgg aggccacggc caggctgtgc      240

tgctgatggc accgtgaggc atgtgaagcg ctgctccagg gccaagcagg agagaagagg      300

ctttcagttc ataaagacca accagcacac tgcaaggacc atgaggccac tgtgtatgac      360

ctactggtgg cttggactgc tggccacggt cggagctgct acaggcccag aggctgacgt      420

tgagggcaca gaggatggtt cacagagaga gtacatttac ctcaacaggt acaagcgggc      480

aggtgagtcc cccgacaagt gcacctacac tttcattgtg ccccagcagc gggtcacagg      540

tgccatttgt gtcaactcca aggagcctga ggtgcacctg gagaaccgtg tgcacaagca      600

ggagctggag ctgctcaaca atgagctgct taagcagaag cggcagatcg agacgctgca      660

gcagctggta gaggtagacg gaggcatcgt gagcgaggtg aagctgctgc gcaaggagag      720

ccgcaacatg aactcgagag tcacgcagct gtacatgcaa cttctacatg agatcattcg      780

aaagcgagac aatgcgctgg agctctccca gctggagaac aggatcctga accagacagc      840

tgacatgctg cagctggcta gcaagtacaa ggacctggag cacaagttcc agcacctggc      900

tatgctggca cacaaccaat cagaggtcat tgctcagctc gaagagcact gccaacgcgt      960

acctgcagcc aggcctatgc cccagccacc cccagcagct ccacctcggg tctaccaacc     1020

acccacctac aaccgcatca tcaaccagat ttccaccaat gagatccaga gtgaccagaa     1080

tctgaaggtg ctgccgccct ccttgcccac catgcctgcc cttaccagtc tcccatcttc     1140

cactgataag ccatcaggtc catggagaga ctgcctgcaa gccctggaag atggtcacag     1200

caccagctcc atctacctgg tgaagcctga gaataccaac cgcctgatgc aggtgtggtg     1260

tgaccagaga catgaccctg gaggttggac tgtcatccag agacgcctgg atggctctgt     1320

caacttcttc aggaactggg agacctataa gcaagggttt gggaacatcg atggtgagta     1380

ctggctgggc ctggagaaca tctactggct gacgaaccaa ggcaactaca aactgctggt     1440

aaccatggag gactggtctg gccgtaaagt ctttgctgag tatgccagtt tccgactgga     1500

gccagaaagc gagtactata agctgcggct ggggcgttat catggcaatg caggcgactc     1560

ctttacctgg cacaacggca aacagtttac caccctggac agggaccatg atgtctacac     1620

aggaaactgt gcccactatc agaagggagg atggtggtat aacgcctgtg ctcactccaa     1680

cctcaatggg gtctggtacc gtgggggcca ttaccggagc agataccagg acggggtcta     1740

ctgggctgag ttccgaggag gctcttactc actcaagaag gtggtgatga tgattcggcc     1800

caaccccaac accttccact aagctctccc tgcctggcca ctaacaccat ggc            1853


<210>  200
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 1

<400>  200
atgaggccac tgtgtatgac ctactggtgg cttggactgc tggccacggt cggagctgct       60

acaggcccag aggctgacgt tgagggcaca gaggatggtt cacagagaga gtacatttac      120

ctcaacaggt acaagcgggc aggtgagtcc cccgacaagt gcacctacac tttcattgtg      180

ccccagcagc gggtcacagg tgccatttgt gtcaactcca aggagcctga ggtgcacctg      240

gagaaccgtg tgcacaagca ggagctggag ctgctcaaca atgagctgct taagcagaag      300

cggcagatcg agacgctgca gcagctggta gaggtagacg gaggcatcgt gagcgaggtg      360

aagctgctgc gcaaggagag ccgcaacatg aactcgagag tcacgcagct gtacatgcaa      420

cttctacatg agatcattcg aaagcgagac aatgcgctgg agctctccca gctggagaac      480

aggatcctga accagacagc tgacatgctg cagctggcta gcaagtacaa ggacctggag      540

cacaagttcc agcacctggc tatgctggca cacaaccaat cagaggtcat tgctcagctc      600

gaagagcact gccaacgcgt acctgcagcc aggcctatgc cccagccacc cccagcagct      660

ccacctcggg tctaccaacc acccacctac aaccgcatca tcaaccagat ttccaccaat      720

gagatccaga gtgaccagaa tctgaaggtg ctgccgccct ccttgcccac catgcctgcc      780

cttaccagtc tcccatcttc cactgataag ccatcaggtc catggagaga ctgcctgcaa      840

gccctggaag atggtcacag caccagctcc atctacctgg tgaagcctga gaataccaac      900

cgcctgatgc aggtgtggtg tgaccagaga catgaccctg gaggttggac tgtcatccag      960

agacgcctgg atggctctgt caacttcttc aggaactggg agacctataa gcaagggttt     1020

gggaacatcg atggtgagta ctggctgggc ctggagaaca tctactggct gacgaaccaa     1080

ggcaactaca aactgctggt aaccatggag gactggtctg gccgtaaagt ctttgctgag     1140

tatgccagtt tccgactgga gccagaaagc gagtactata agctgcggct ggggcgttat     1200

catggcaatg caggcgactc ctttacctgg cacaacggca aacagtttac caccctggac     1260

agggaccatg atgtctacac aggaaactgt gcccactatc agaagggagg atggtggtat     1320

aacgcctgtg ctcactccaa cctcaatggg gtctggtacc gtgggggcca ttaccggagc     1380

agataccagg acggggtcta ctgggctgag ttccgaggag gctcttactc actcaagaag     1440

gtggtgatga tgattcggcc caaccccaac accttccact aa                        1482


<210>  201
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 2

<400>  201

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Thr Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Met Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  202
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 3

<400>  202

Gly Arg Ala Ala Arg Arg Pro Val Gln Pro Glu Thr Arg Asp Leu Ser 
1               5                   10                  15      


Trp Arg Pro Arg Pro Gly Cys Ala Ala Asp Gly Thr Val Arg His Val 
            20                  25                  30          


Lys Arg Cys Ser Arg Ala Lys Gln Glu Arg Arg Gly Phe Gln Phe Ile 
        35                  40                  45              


Lys Thr Asn Gln His Thr Ala Arg Thr Met Arg Pro Leu Cys Met Thr 
    50                  55                  60                  


Tyr Trp Trp Leu Gly Leu Leu Ala Thr Val Gly Ala Ala Thr Gly Pro 
65                  70                  75                  80  


Glu Ala Asp Val Glu Gly Thr Glu Asp Gly Ser Gln Arg Glu Tyr Ile 
                85                  90                  95      


Tyr Leu Asn Arg Tyr Lys Arg Ala Gly Glu Ser Pro Asp Lys Cys Thr 
            100                 105                 110         


Tyr Thr Phe Ile Val Pro Gln Gln Arg Val Thr Gly Ala Ile Cys Val 
        115                 120                 125             


Asn Ser Lys Glu Pro Glu Val His Leu Glu Asn Arg Val His Lys Gln 
    130                 135                 140                 


Glu Leu Glu Leu Leu Asn Asn Glu Leu Leu Lys Gln Lys Arg Gln Ile 
145                 150                 155                 160 


Glu Thr Leu Gln Gln Leu Val Glu Val Asp Gly Gly Ile Val Ser Glu 
                165                 170                 175     


Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser Arg Val Thr 
            180                 185                 190         


Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys Arg Asp Asn 
        195                 200                 205             


Ala Leu Glu Leu Ser Gln Leu Glu Asn Arg Ile Leu Asn Gln Thr Ala 
    210                 215                 220                 


Asp Met Leu Gln Leu Ala Ser Lys Tyr Lys Asp Leu Glu His Lys Phe 
225                 230                 235                 240 


Gln His Leu Ala Met Leu Ala His Asn Gln Ser Glu Val Ile Ala Gln 
                245                 250                 255     


Leu Glu Glu His Cys Gln Arg Val Pro Ala Ala Arg Pro Met Pro Gln 
            260                 265                 270         


Pro Pro Pro Ala Ala Pro Pro Arg Val Tyr Gln Pro Pro Thr Tyr Asn 
        275                 280                 285             


Arg Ile Ile Asn Gln Ile Ser Thr Asn Glu Ile Gln Ser Asp Gln Asn 
    290                 295                 300                 


Leu Lys Val Leu Pro Pro Ser Leu Pro Thr Met Pro Ala Leu Thr Ser 
305                 310                 315                 320 


Leu Pro Ser Ser Thr Asp Lys Pro Ser Gly Pro Trp Arg Asp Cys Leu 
                325                 330                 335     


Gln Ala Leu Glu Asp Gly His Ser Thr Ser Ser Ile Tyr Leu Val Lys 
            340                 345                 350         


Pro Glu Asn Thr Asn Arg Leu Met Gln Val Trp Cys Asp Gln Arg His 
        355                 360                 365             


Asp Pro Gly Gly Trp Thr Val Ile Gln Arg Arg Leu Asp Gly Ser Val 
    370                 375                 380                 


Asn Phe Phe Arg Asn Trp Glu Thr Tyr Lys Val Arg Pro Leu Gly Leu 
385                 390                 395                 400 


Tyr Ala Leu Pro Val Arg 
                405     


<210>  203
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 4

<400>  203

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Thr Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Met Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  204
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 5

<400>  204

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Thr Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Met Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  205
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 6

<400>  205

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Thr Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Met Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  206
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 7

<400>  206

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Thr Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Met Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  207
<211>  2138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 mRNA 1

<400>  207
aactgaggct gctgctgtcg gcctggggat ggaccccaag ccctgagtgg tgctgttgga       60

cccaggacct gcaaggagca cgcactaagg cagctacgga ccacgctgtg agggagagca      120

ggttgggagc agccccagtg acaccagagc cagcctcatc cctaagagct tctaagagca      180

tagactgctg ccagctgagg ccagtaaggc agggctgctc ggcggccagt ccagcctaag      240

actcgggacc tctcctggag gccacggcca ggctgtcccg ctgatggcac cgggaagcat      300

gtgaagaccc tgctccaggg ccaagcagga gagaagaggt ttcaagagac ctcattcata      360

aagaccaagg agcacactgc aaggaccatg aggccactgt gtatgactta ctggtggctt      420

ggactgctgg ccaccgtggg agctgttaca ggcccagagg ctgatgttga gggcgcagag      480

gatggttcgc agagagagta catttacctc aacaggtaca agagggcagg tgagtcccca      540

gacaagtgca cctacacttt cattgtgccc cagcagcggg tcacaggtgc catttgtgtc      600

aactccaaag agcccgaggt gcacctggag aaccgtgtgc acaagcagga gctggagctg      660

ctcaacaatg agctgcttaa gcagaagcgg cagatcgaga cgctgcagca gctggtagag      720

gtagatggcg gcatcgtgag cgaggtgaag ctcgtgcgca aggagagccg caacatgaac      780

tctcgggtca cacagctgta catgcagctt ctacacgaga tcattcgcaa gcgagacaat      840

gcgctggagc tttcccagct ggagaacagg atcctgaacc agacagctga catgctgcag      900

ctggtgagca agtacaagga cctggagcac aagttccagc acctggatat gctggcacac      960

aaccaatcag aggtcattgc ccagcttgaa gagcactgcc aacgtgtacc tgcagccagg     1020

cctgtgcccc agccaccccc agccacgcca cctcgggtct accagccacc aacctacaac     1080

cgcatcatca accagatctc cactaatgag atccagagtg accagaatct gaaggtgctg     1140

ccaccctccc tgcccaccat gcctgccctt accagtctcc catcttccac tgataagcca     1200

tcaggtccat ggagagattg tctacaggcc ctggaggatg gtcacagcac cagctccatc     1260

tacctggtga agccggagaa taccaaccgc cttatgcagg tgtggtgcga ccagagacat     1320

gaccctgggg gttggactgt catccagaga cgcctggatg gctctgtcaa cttcttcagg     1380

aactgggaga cctataagca agggtttggg aacatcgacg gcgaatactg gctgggcctg     1440

gagaacatct actggctgac gaaccaaggc aactacaaat tgcttgtaac catggaggac     1500

tggtctggcc gcaaagtctt tgcagagtat gctagcttcc gactggagcc agaaagcgag     1560

tactataagc tgcggctggg gcgttatcac ggcaacgcag gcgactcctt tacctggcac     1620

aacggcaaac agttcaccac cctggacagg gaccatgatg tctacacagg aaactgtgcc     1680

cactatcaga agggaggatg gtggtacaat gcctgtgctc actccaacct caatggggtc     1740

tggtaccgtg ggggccatta ccggagccga taccaggatg gggtctactg ggctgagttc     1800

cgaggaggat cttactcact caagaaggtg gtgatgatga ttcggcccaa ccccaacact     1860

ttccattaag ctctctctgc ctggccactt acggcattgc cagaagccat cccaactgtg     1920

cgacgtcagc acagctcttc actggcccac ctcaggctgg gaggacagag tgctggactc     1980

tgctctccaa gtggctgtca gatgatggag atgaaagggc ttctctgccc ctcctgcctt     2040

cttttacacc cagccatccc tgtattccag gacaggacag aactgcaatc ttccaatcag     2100

ttaagtctta ataaaaattt caactgccaa aaaaaaaa                             2138


<210>  208
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 1

<400>  208

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Val Thr Gly Pro Glu Ala Asp Val Glu Gly Ala Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Val Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Val Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Asp Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Thr Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  209
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2 protein 2

<400>  209

Met Arg Pro Leu Cys Met Thr Tyr Trp Trp Leu Gly Leu Leu Ala Thr 
1               5                   10                  15      


Val Gly Ala Ala Thr Gly Pro Glu Ala Asp Val Glu Gly Ala Glu Asp 
            20                  25                  30          


Gly Ser Gln Arg Glu Tyr Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Pro Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val His Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Phe Gln His Leu Ala Met Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Val Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ala Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Thr Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Ser Leu Pro 
                245                 250                 255     


Thr Met Pro Ala Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Ser Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


