                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED COAGULATION FACTOR 12 
       LOCUS

<130>  057766-545986

<150>  US 62/829,321
<151>  2019-04-04

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  597
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (20)..(354)
<223>  Heavy Chain

<220>
<221>  MISC_FEATURE
<222>  (355)..(597)
<223>  Light Chain

<400>  1

Met Thr Ala Leu Leu Phe Leu Gly Ser Leu Leu Met Ser Leu Asp Leu 
1               5                   10                  15      


Thr Leu Ser Ala Pro Pro Trp Lys Asp Ser Lys Lys Phe Lys Asp Ala 
            20                  25                  30          


Pro Asp Gly Pro Thr Val Val Leu Thr Val Asp Gly Arg Leu Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu His His Lys Cys Ile His Lys 
    50                  55                  60                  


Arg Arg Pro Gly Ser Arg Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Glu Asp Gln Gln Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Asn Pro Cys His Lys Gly Gly Thr Cys Ile Asn 
            100                 105                 110         


Thr Pro Asn Gly Pro His Cys Leu Cys Pro Glu His Leu Thr Gly Lys 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Lys Phe Phe 
    130                 135                 140                 


His Glu Asn Glu Leu Trp Phe Arg Thr Gly Pro Gly Gly Val Ala Arg 
145                 150                 155                 160 


Cys Glu Cys Lys Gly Ser Glu Ala His Cys Lys Pro Val Ala Ser Gln 
                165                 170                 175     


Ala Cys Ser Ile Asn Pro Cys Leu Asn Gly Gly Ser Cys Leu Leu Val 
            180                 185                 190         


Glu Asp His Pro Leu Cys Arg Cys Pro Thr Gly Tyr Thr Gly Tyr Phe 
        195                 200                 205             


Cys Asp Leu Asp Leu Trp Ala Thr Cys Tyr Glu Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Gln Ala Gly Thr Thr Gln Ser Gly Ala Pro Cys Gln Arg 
225                 230                 235                 240 


Trp Thr Val Glu Ala Thr Tyr Arg Asn Met Thr Glu Lys Gln Ala Leu 
                245                 250                 255     


Ser Trp Gly Leu Gly His His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Thr Arg Pro Trp Cys Phe Val Trp Ser Gly Asp Arg Leu Ser Trp Asp 
        275                 280                 285             


Tyr Cys Gly Leu Glu Gln Cys Gln Thr Pro Thr Phe Ala Pro Leu Val 
    290                 295                 300                 


Val Pro Glu Ser Gln Glu Glu Ser Pro Ser Gln Ala Pro Ser Leu Ser 
305                 310                 315                 320 


His Ala Pro Asn Asp Ser Thr Asp His Gln Thr Ser Leu Ser Lys Thr 
                325                 330                 335     


Asn Thr Met Gly Cys Gly Gln Arg Phe Arg Lys Gly Leu Ser Ser Phe 
            340                 345                 350         


Met Arg Val Val Gly Gly Leu Val Ala Leu Pro Gly Ser His Pro Tyr 
        355                 360                 365             


Ile Ala Ala Leu Tyr Trp Gly Asn Asn Phe Cys Ala Gly Ser Leu Ile 
    370                 375                 380                 


Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asn Arg Pro 
385                 390                 395                 400 


Ala Pro Glu Glu Leu Thr Val Val Leu Gly Gln Asp Arg His Asn Gln 
                405                 410                 415     


Ser Cys Glu Trp Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu His 
            420                 425                 430         


Glu Gly Phe Ser Ser Ile Thr Tyr Gln His Asp Leu Ala Leu Leu Arg 
        435                 440                 445             


Leu Gln Glu Ser Lys Thr Asn Ser Cys Ala Ile Leu Ser Pro His Val 
    450                 455                 460                 


Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Pro Pro Ser Glu Thr Val 
465                 470                 475                 480 


Leu Cys Glu Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu 
                485                 490                 495     


Tyr Ser Thr Phe Leu Gln Glu Ala Gln Val Pro Phe Ile Ala Leu Asp 
            500                 505                 510         


Arg Cys Ser Asn Ser Asn Val His Gly Asp Ala Ile Leu Pro Gly Met 
        515                 520                 525             


Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly Asp 
    530                 535                 540                 


Ser Gly Gly Pro Leu Val Cys Glu Glu Gly Thr Ala Glu His Gln Leu 
545                 550                 555                 560 


Thr Leu Arg Gly Val Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn 
                565                 570                 575     


Lys Pro Gly Val Tyr Thr Asp Val Ala Asn Tyr Leu Ala Trp Ile Gln 
            580                 585                 590         


Lys His Ile Ala Ser 
        595         


<210>  2
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  2

Met Thr Ala Leu Leu Phe Leu Gly Ser Leu Leu Met Ser Leu Asp Leu 
1               5                   10                  15      


Thr Leu Ser 
            


<210>  3
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Pro Pro Trp Lys Asp Ser Lys Lys Phe Lys Asp Ala Pro Asp Gly 
1               5                   10                  15      


Pro Thr Val Val Leu Thr Val Asp Gly Arg Leu Cys His Phe Pro Phe 
            20                  25                  30          


Gln Tyr His Arg Gln Leu His His Lys Cys Ile His Lys Arg Arg Pro 
        35                  40                  45              


Gly Ser Arg Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp Glu Asp Gln 
    50                  55                  60                  


Gln Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp His Cys Ser 
65                  70                  75                  80  


Lys His Asn Pro Cys His Lys Gly Gly Thr Cys Ile Asn Thr Pro Asn 
                85                  90                  95      


Gly Pro His Cys Leu Cys Pro Glu His Leu Thr Gly Lys His Cys Gln 
            100                 105                 110         


Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Lys Phe Phe His Glu Asn 
        115                 120                 125             


Glu Leu Trp Phe Arg Thr Gly Pro Gly Gly Val Ala Arg Cys Glu Cys 
    130                 135                 140                 


Lys Gly Ser Glu Ala His Cys Lys Pro Val Ala Ser Gln Ala Cys Ser 
145                 150                 155                 160 


Ile Asn Pro Cys Leu Asn Gly Gly Ser Cys Leu Leu Val Glu Asp His 
                165                 170                 175     


Pro Leu Cys Arg Cys Pro Thr Gly Tyr Thr Gly Tyr Phe Cys Asp Leu 
            180                 185                 190         


Asp Leu Trp Ala Thr Cys Tyr Glu Gly Arg Gly Leu Ser Tyr Arg Gly 
        195                 200                 205             


Gln Ala Gly Thr Thr Gln Ser Gly Ala Pro Cys Gln Arg Trp Thr Val 
    210                 215                 220                 


Glu Ala Thr Tyr Arg Asn Met Thr Glu Lys Gln Ala Leu Ser Trp Gly 
225                 230                 235                 240 


Leu Gly His His Ala Phe Cys Arg Asn Pro Asp Asn Asp Thr Arg Pro 
                245                 250                 255     


Trp Cys Phe Val Trp Ser Gly Asp Arg Leu Ser Trp Asp Tyr Cys Gly 
            260                 265                 270         


Leu Glu Gln Cys Gln Thr Pro Thr Phe Ala Pro Leu Val Val Pro Glu 
        275                 280                 285             


Ser Gln Glu Glu Ser Pro Ser Gln Ala Pro Ser Leu Ser His Ala Pro 
    290                 295                 300                 


Asn Asp Ser Thr Asp His Gln Thr Ser Leu Ser Lys Thr Asn Thr Met 
305                 310                 315                 320 


Gly Cys Gly Gln Arg Phe Arg Lys Gly Leu Ser Ser Phe Met Arg 
                325                 330                 335 


<210>  4
<211>  243
<212>  PRT
<213>  Mus musculus

<400>  4

Val Val Gly Gly Leu Val Ala Leu Pro Gly Ser His Pro Tyr Ile Ala 
1               5                   10                  15      


Ala Leu Tyr Trp Gly Asn Asn Phe Cys Ala Gly Ser Leu Ile Ala Pro 
            20                  25                  30          


Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asn Arg Pro Ala Pro 
        35                  40                  45              


Glu Glu Leu Thr Val Val Leu Gly Gln Asp Arg His Asn Gln Ser Cys 
    50                  55                  60                  


Glu Trp Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu His Glu Gly 
65                  70                  75                  80  


Phe Ser Ser Ile Thr Tyr Gln His Asp Leu Ala Leu Leu Arg Leu Gln 
                85                  90                  95      


Glu Ser Lys Thr Asn Ser Cys Ala Ile Leu Ser Pro His Val Gln Pro 
            100                 105                 110         


Val Cys Leu Pro Ser Gly Ala Ala Pro Pro Ser Glu Thr Val Leu Cys 
        115                 120                 125             


Glu Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu Tyr Ser 
    130                 135                 140                 


Thr Phe Leu Gln Glu Ala Gln Val Pro Phe Ile Ala Leu Asp Arg Cys 
145                 150                 155                 160 


Ser Asn Ser Asn Val His Gly Asp Ala Ile Leu Pro Gly Met Leu Cys 
                165                 170                 175     


Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Val Cys Glu Glu Gly Thr Ala Glu His Gln Leu Thr Leu 
        195                 200                 205             


Arg Gly Val Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asp Val Ala Asn Tyr Leu Ala Trp Ile Gln Lys His 
225                 230                 235                 240 


Ile Ala Ser 
            


<210>  5
<211>  615
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (20)..(372)
<223>  Heavy Chain

<220>
<221>  MISC_FEATURE
<222>  (373)..(615)
<223>  Light Chain

<400>  5

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Pro Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  6
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser 
            


<210>  7
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys Ala Glu Glu 
1               5                   10                  15      


His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His Phe Pro Phe 
            20                  25                  30          


Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys Gly Arg Pro 
        35                  40                  45              


Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp Gln Asp Gln 
    50                  55                  60                  


Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp His Cys Ser 
65                  70                  75                  80  


Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn Met Pro Ser 
                85                  90                  95      


Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn His Cys Gln 
            100                 105                 110         


Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe His Lys Asn 
        115                 120                 125             


Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg Cys Gln Cys 
    130                 135                 140                 


Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln Ala Cys Arg 
145                 150                 155                 160 


Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val Glu Gly His 
                165                 170                 175     


Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Pro Phe Cys Asp Val 
            180                 185                 190         


Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser Tyr Arg Gly 
        195                 200                 205             


Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro Trp Ala Ser 
    210                 215                 220                 


Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg Asn Trp Gly 
225                 230                 235                 240 


Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp Ile Arg Pro 
                245                 250                 255     


Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu Tyr Cys Asp 
            260                 265                 270         


Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro Thr Pro Val 
        275                 280                 285             


Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro Ala Pro Pro 
    290                 295                 300                 


Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln Thr Pro Gly 
305                 310                 315                 320 


Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr Arg Asn Gly 
                325                 330                 335     


Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser Ser Met Thr 
            340                 345                 350         


Arg 
    


<210>  8
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His Pro Tyr Ile Ala 
1               5                   10                  15      


Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser Leu Ile Ala Pro 
            20                  25                  30          


Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp Arg Pro Ala Pro 
        35                  40                  45              


Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg Asn His Ser Cys 
    50                  55                  60                  


Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu His Glu Ala 
65                  70                  75                  80  


Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu Leu Arg Leu Gln 
                85                  90                  95      


Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro Tyr Val Gln Pro 
            100                 105                 110         


Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu Thr Thr Leu Cys 
        115                 120                 125             


Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu Tyr Ala 
    130                 135                 140                 


Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser Leu Glu Arg Cys 
145                 150                 155                 160 


Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro Gly Met Leu Cys 
                165                 170                 175     


Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg Arg Leu Thr Leu 
        195                 200                 205             


Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp Ile Arg Glu His 
225                 230                 235                 240 


Thr Val Ser 
            


<210>  9
<211>  1794
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (58)..(1062)
<223>  Heavy Chain

<220>
<221>  misc_feature
<222>  (1063)..(1791)
<223>  Light Chain

<400>  9
atgacggctc tgttgttcct ggggtctctg ctgatgagtc tggatctgac actttcggct       60

ccaccatgga aagactccaa gaaatttaag gacgcacctg atgggcccac agtggttctc      120

actgtggatg ggaggctctg ccattttccc tttcagtacc accgtcagct acaccacaaa      180

tgcatccaca aaaggcggcc aggctcccgc ccctggtgtg ctaccacccc caactttgat      240

gaagatcagc aatggggata ctgcttggag cccaagaaag tgaaagacca ttgcagcaaa      300

cacaacccgt gccacaaagg agggacatgt atcaacaccc ccaatgggcc acactgtctc      360

tgccctgaac acctcactgg gaaacattgc cagaaagaga aatgctttga gcctcagctt      420

ctcaagttct tccacgagaa tgagctatgg tttagaacgg ggccaggagg tgtggccagg      480

tgcgagtgca aaggttctga ggctcactgc aagccggtgg ccagccaggc ctgcagcatc      540

aatccgtgcc ttaatggggg cagctgcctc ctcgtggagg accacccact gtgccgttgc      600

cctacaggct acactggata tttttgcgac ttggaccttt gggcgacctg ctatgaaggc      660

agggggctca gctaccgggg ccaggctgga actacgcaat cgggtgcgcc atgtcagcgg      720

tggaccgtgg aggccaccta ccggaacatg actgagaagc aagcgctaag ctggggcctg      780

ggccaccacg cattttgccg gaacccagat aatgacacac gtccatggtg cttcgtctgg      840

agtggcgaca ggctgagctg ggactattgc ggcctggagc agtgccagac gccaacgttt      900

gcacctctag ttgtccctga gagtcaggag gagtccccgt cccaggcacc atctctgtcc      960

catgcaccaa atgactcgac cgatcatcag acttctctgt ccaagaccaa cacgatgggc     1020

tgcggacaga ggttccgcaa gggactgtcc tcgttcatgc gcgtggtggg cggactagtg     1080

gctctgcctg ggtcgcaccc ctacatcgct gcactgtact ggggtaacaa cttctgcgcg     1140

ggcagtctca tcgccccctg ttgggtgctg accgcggctc actgcctgca gaatcggcca     1200

gcgcccgagg aactgacagt ggtacttggt caagatcgcc acaaccagag ctgcgagtgg     1260

tgccagactc tggctgtgcg ctcctaccgc cttcacgagg gcttctcctc catcacctac     1320

cagcacgact tggctctgct gcgcctgcag gaaagcaaaa ccaacagttg cgcgatcctg     1380

tcacctcacg ttcagcctgt gtgtctaccc agcggcgcgg ccccaccctc tgagacagtg     1440

ctctgcgagg tggccggctg gggtcaccag ttcgaggggg ctgaagaata ctccaccttc     1500

ctgcaggagg cacaggttcc ctttatcgcc ctggatcgct gctccaactc taacgtgcac     1560

ggagacgcca ttctccctgg gatgctttgc gctggcttct tggagggagg caccgatgcc     1620

tgccagggtg actccggggg ccctctggtg tgtgaggaag gaactgcaga acatcagctc     1680

accctgcgcg gagtcatcag ctggggctcc ggctgtggtg accgcaacaa gcccggagtc     1740

tacacagacg tggccaacta cctggcttgg atccagaagc atattgcttc ataa           1794


<210>  10
<211>  57
<212>  DNA
<213>  Mus musculus

<400>  10
atgacggctc tgttgttcct ggggtctctg ctgatgagtc tggatctgac actttcg          57


<210>  11
<211>  1005
<212>  DNA
<213>  Mus musculus

<400>  11
gctccaccat ggaaagactc caagaaattt aaggacgcac ctgatgggcc cacagtggtt       60

ctcactgtgg atgggaggct ctgccatttt ccctttcagt accaccgtca gctacaccac      120

aaatgcatcc acaaaaggcg gccaggctcc cgcccctggt gtgctaccac ccccaacttt      180

gatgaagatc agcaatgggg atactgcttg gagcccaaga aagtgaaaga ccattgcagc      240

aaacacaacc cgtgccacaa aggagggaca tgtatcaaca cccccaatgg gccacactgt      300

ctctgccctg aacacctcac tgggaaacat tgccagaaag agaaatgctt tgagcctcag      360

cttctcaagt tcttccacga gaatgagcta tggtttagaa cggggccagg aggtgtggcc      420

aggtgcgagt gcaaaggttc tgaggctcac tgcaagccgg tggccagcca ggcctgcagc      480

atcaatccgt gccttaatgg gggcagctgc ctcctcgtgg aggaccaccc actgtgccgt      540

tgccctacag gctacactgg atatttttgc gacttggacc tttgggcgac ctgctatgaa      600

ggcagggggc tcagctaccg gggccaggct ggaactacgc aatcgggtgc gccatgtcag      660

cggtggaccg tggaggccac ctaccggaac atgactgaga agcaagcgct aagctggggc      720

ctgggccacc acgcattttg ccggaaccca gataatgaca cacgtccatg gtgcttcgtc      780

tggagtggcg acaggctgag ctgggactat tgcggcctgg agcagtgcca gacgccaacg      840

tttgcacctc tagttgtccc tgagagtcag gaggagtccc cgtcccaggc accatctctg      900

tcccatgcac caaatgactc gaccgatcat cagacttctc tgtccaagac caacacgatg      960

ggctgcggac agaggttccg caagggactg tcctcgttca tgcgc                     1005


<210>  12
<211>  729
<212>  DNA
<213>  Mus musculus

<400>  12
gtggtgggcg gactagtggc tctgcctggg tcgcacccct acatcgctgc actgtactgg       60

ggtaacaact tctgcgcggg cagtctcatc gccccctgtt gggtgctgac cgcggctcac      120

tgcctgcaga atcggccagc gcccgaggaa ctgacagtgg tacttggtca agatcgccac      180

aaccagagct gcgagtggtg ccagactctg gctgtgcgct cctaccgcct tcacgagggc      240

ttctcctcca tcacctacca gcacgacttg gctctgctgc gcctgcagga aagcaaaacc      300

aacagttgcg cgatcctgtc acctcacgtt cagcctgtgt gtctacccag cggcgcggcc      360

ccaccctctg agacagtgct ctgcgaggtg gccggctggg gtcaccagtt cgagggggct      420

gaagaatact ccaccttcct gcaggaggca caggttccct ttatcgccct ggatcgctgc      480

tccaactcta acgtgcacgg agacgccatt ctccctggga tgctttgcgc tggcttcttg      540

gagggaggca ccgatgcctg ccagggtgac tccgggggcc ctctggtgtg tgaggaagga      600

actgcagaac atcagctcac cctgcgcgga gtcatcagct ggggctccgg ctgtggtgac      660

cgcaacaagc ccggagtcta cacagacgtg gccaactacc tggcttggat ccagaagcat      720

attgcttca                                                              729


<210>  13
<211>  1848
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (58)..(1116)
<223>  Heavy Chain

<220>
<221>  misc_feature
<222>  (1117)..(1845)
<223>  Light Chain

<400>  13
atgagggctc tgctgctcct ggggttcctg ctggtgagct tggagtcaac actttcgatt       60

ccaccttggg aagcccccaa ggagcataag tacaaagctg aagagcacac agtcgttctc      120

actgtcaccg gggagccctg ccacttcccc ttccagtacc accggcagct gtaccacaaa      180

tgtacccaca agggccggcc aggccctcag ccctggtgtg ctaccacccc caactttgat      240

caggaccagc gatggggata ctgtttggag cccaagaaag tgaaagacca ctgcagcaaa      300

cacagcccct gccagaaagg agggacctgt gtgaacatgc caagcggccc ccactgtctc      360

tgtccacaac acctcactgg aaaccactgc cagaaagaga agtgctttga gcctcagctt      420

ctccggtttt tccacaagaa tgagatatgg tatagaactg agcaagcagc tgtggccaga      480

tgccagtgca agggtcctga tgcccactgc cagcggctgg ccagccaggc ctgccgcacc      540

aacccgtgcc tccatggggg tcgctgccta gaggtggagg gccaccgcct gtgccactgc      600

ccggtgggct acaccggacc cttctgcgac gtggacacca aggcaagctg ctatgatggc      660

cgcgggctca gctaccgcgg cctggccagg accacgctct cgggtgcgcc ctgtcagccg      720

tgggcctcgg aggccaccta ccggaacgtg actgccgagc aagcgcggaa ctggggactg      780

ggcggccacg ccttctgccg gaacccggac aacgacatcc gcccgtggtg cttcgtgctg      840

aaccgcgacc ggctgagctg ggagtactgc gacctggcac agtgccagac cccaacccag      900

gcggcgcctc cgaccccggt gtcccctagg cttcatgtcc cactcatgcc cgcgcagccg      960

gcaccgccga agcctcagcc cacgacccgg accccgcctc agtcccagac cccgggagcc     1020

ttgccggcga agcgggagca gccgccttcc ctgaccagga acggcccact gagctgcggg     1080

cagcggctcc gcaagagtct gtcttcgatg acccgcgtcg ttggcgggct ggtggcgcta     1140

cgcggggcgc acccctacat cgccgcgctg tactggggcc acagtttctg cgccggcagc     1200

ctcatcgccc cctgctgggt gctgacggcc gctcactgcc tgcaggaccg gcccgcaccc     1260

gaggatctga cggtggtgct cggccaggaa cgccgtaacc acagctgtga gccgtgccag     1320

acgttggccg tgcgctccta ccgcttgcac gaggccttct cgcccgtcag ctaccagcac     1380

gacctggctc tgttgcgcct tcaggaggat gcggacggca gctgcgcgct cctgtcgcct     1440

tacgttcagc cggtgtgcct gccaagcggc gccgcgcgac cctccgagac cacgctctgc     1500

caggtggccg gctggggcca ccagttcgag ggggcggagg aatatgccag cttcctgcag     1560

gaggcgcagg taccgttcct ctccctggag cgctgctcag ccccggacgt gcacggatcc     1620

tccatcctcc ccggcatgct ctgcgcaggg ttcctcgagg gcggcaccga tgcgtgccag     1680

ggtgattccg gaggcccgct ggtgtgtgag gaccaagctg cagagcgccg gctcaccctg     1740

caaggcatca tcagctgggg atcgggctgt ggtgaccgca acaagccagg cgtctacacc     1800

gatgtggcct actacctggc ctggatccgg gagcacaccg tttcctga                  1848


<210>  14
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  14
atgagggctc tgctgctcct ggggttcctg ctggtgagct tggagtcaac actttcg          57


<210>  15
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  15
attccacctt gggaagcccc caaggagcat aagtacaaag ctgaagagca cacagtcgtt       60

ctcactgtca ccggggagcc ctgccacttc cccttccagt accaccggca gctgtaccac      120

aaatgtaccc acaagggccg gccaggccct cagccctggt gtgctaccac ccccaacttt      180

gatcaggacc agcgatgggg atactgtttg gagcccaaga aagtgaaaga ccactgcagc      240

aaacacagcc cctgccagaa aggagggacc tgtgtgaaca tgccaagcgg cccccactgt      300

ctctgtccac aacacctcac tggaaaccac tgccagaaag agaagtgctt tgagcctcag      360

cttctccggt ttttccacaa gaatgagata tggtatagaa ctgagcaagc agctgtggcc      420

agatgccagt gcaagggtcc tgatgcccac tgccagcggc tggccagcca ggcctgccgc      480

accaacccgt gcctccatgg gggtcgctgc ctagaggtgg agggccaccg cctgtgccac      540

tgcccggtgg gctacaccgg acccttctgc gacgtggaca ccaaggcaag ctgctatgat      600

ggccgcgggc tcagctaccg cggcctggcc aggaccacgc tctcgggtgc gccctgtcag      660

ccgtgggcct cggaggccac ctaccggaac gtgactgccg agcaagcgcg gaactgggga      720

ctgggcggcc acgccttctg ccggaacccg gacaacgaca tccgcccgtg gtgcttcgtg      780

ctgaaccgcg accggctgag ctgggagtac tgcgacctgg cacagtgcca gaccccaacc      840

caggcggcgc ctccgacccc ggtgtcccct aggcttcatg tcccactcat gcccgcgcag      900

ccggcaccgc cgaagcctca gcccacgacc cggaccccgc ctcagtccca gaccccggga      960

gccttgccgg cgaagcggga gcagccgcct tccctgacca ggaacggccc actgagctgc     1020

gggcagcggc tccgcaagag tctgtcttcg atgacccgc                            1059


<210>  16
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  16
gtcgttggcg ggctggtggc gctacgcggg gcgcacccct acatcgccgc gctgtactgg       60

ggccacagtt tctgcgccgg cagcctcatc gccccctgct gggtgctgac ggccgctcac      120

tgcctgcagg accggcccgc acccgaggat ctgacggtgg tgctcggcca ggaacgccgt      180

aaccacagct gtgagccgtg ccagacgttg gccgtgcgct cctaccgctt gcacgaggcc      240

ttctcgcccg tcagctacca gcacgacctg gctctgttgc gccttcagga ggatgcggac      300

ggcagctgcg cgctcctgtc gccttacgtt cagccggtgt gcctgccaag cggcgccgcg      360

cgaccctccg agaccacgct ctgccaggtg gccggctggg gccaccagtt cgagggggcg      420

gaggaatatg ccagcttcct gcaggaggcg caggtaccgt tcctctccct ggagcgctgc      480

tcagccccgg acgtgcacgg atcctccatc ctccccggca tgctctgcgc agggttcctc      540

gagggcggca ccgatgcgtg ccagggtgat tccggaggcc cgctggtgtg tgaggaccaa      600

gctgcagagc gccggctcac cctgcaaggc atcatcagct ggggatcggg ctgtggtgac      660

cgcaacaagc caggcgtcta caccgatgtg gcctactacc tggcctggat ccgggagcac      720

accgtttcc                                                              729


<210>  17
<211>  12176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (20)..(3893)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  Start Codon

<220>
<221>  misc_feature
<222>  (3742)..(3812)
<223>  Exon 4

<220>
<221>  misc_feature
<222>  (3894)..(8703)
<223>  Neo Self-Deleting Cassette

<220>
<221>  misc_feature
<222>  (3894)..(3899)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (3900)..(3933)
<223>  LoxP

<220>
<221>  misc_feature
<222>  (8632)..(8665)
<223>  LoxP

<220>
<221>  misc_feature
<222>  (8672)..(8697)
<223>  I_Ceu

<220>
<221>  misc_feature
<222>  (8698)..(8703)
<223>  NheI

<220>
<221>  misc_feature
<222>  (8704)..(12065)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (8924)..(9034)
<223>  Exon 5

<220>
<221>  misc_feature
<222>  (9172)..(9303)
<223>  Exon 6

<220>
<221>  misc_feature
<222>  (9443)..(9547)
<223>  Exon 7

<220>
<221>  misc_feature
<222>  (12063)..(12065)
<223>  Stop Codon

<220>
<221>  misc_feature
<222>  (12066)..(12176)
<223>  Mouse Sequence

<400>  17
ggggccatcg gcagacgcca tgagggctct gctgctcctg gggttcctgc tggtgagctt       60

ggagtcaaca ctttcggtga gtgctgtggg aaccaggatt gtcccaggat tgttctgggg      120

ggtcgctatc acagccatga gccatggcct ctgctcatga cctgtgggtc caggtgacta      180

ggaggcctat gtggaaaggt gaggccagcc cggaaggccc aggcagagga gacagacaac      240

cagactgggt ggatacaagg gcacagcctg catttctggg ggagatgggc cttaagaaga      300

caacgggggg aggtagaaag ggtttgggtc ttgggaagaa atctctgcat ttctgggctg      360

tgagaggaag ctgcagacta gcaacagatc ggtggcaggc tatgacttat agtcagttcc      420

ctgccttctt ctctcccttg tagattccac cttgggaagc ccccaaggag cataagtaca      480

aagctgaaga gcacacagtc ggtaagtggc ctggctcctc ctcccgggaa cccttgggtg      540

gggatgtgta tggtgcagtg tgtgcagtct cagggcagtc tagtctagtg cctacctggt      600

gctaggtctt atgcccatgg gcactagagt gatcgtgagc tgtgtgatcc ttgagggcag      660

ggtatgggct gtgtctaagt gcccacgagc ctggctcgga gcaggtgctt gagatatgtg      720

ctgctggcgc catcacacct gggctcctgc cagccttcct cagtttcccc agcttctccc      780

cttcttttcc tttccccagt acgtctcatg ggcatcattc atgccacaca gaggccaggg      840

ccttcaatgg gcaaggaagg atcaagagct tgtctctggc atctgaatgc ctctgaagcc      900

cagctttatc acttatgagc tgggtgactc tgggcgaggg atttgagttc tccaagcttc      960

aatttcccct tctgtgaaac caggttgata acagtaaacc tcttagggtt gttgagaagg     1020

gaaacccatg tgaggtattc agcccatcac ctggtgcatg gaaatgcttt acaaatatta     1080

gcttttatta tgaaactacc ttttagatga agggtacctg ccatttcccc cttcctcaag     1140

ctctgccata gctccccatt gctttcattc ttccagacac taaattacct acatgccagg     1200

catggtggct catgcctgta atcccagcac tttgggaggc caaggtcggt ggatcatgag     1260

gtcaggagtt cgagaccagc ctggccaaca tggtgaaatg ctgtctctac taaaagtaca     1320

aaaattagcc aggcatggtg gcatgcgcca gtagtcccag ctactcggga ggctgaggca     1380

gaagaattgc ttgaacctgg gaggtgaagg ttgcagtgaa cgaagatcac accattgcac     1440

tccagcttgg gcaacacagc aagactccgt ctcaaaaaaa aaaaaaaaat ttacctagag     1500

tgtggcacat agcagggcct gtgaaccaga tggaccttac cctggtgggc ctgacttggt     1560

ggggttgagt ctctaagcat ggcgttgagg cccagcacat tccaaccctg gactccctca     1620

gcctcctctc ttcaccccac acccaaaagt ttctcctctc tcttgcctta cccaaacttg     1680

gtgccctatc cttgcctaat cccctgccta aggtccccct cctctctgtc cgtccatccc     1740

atctgcatct tttttttttt ttgagatgga gtctcgctct gtcccctagg ctagagtgca     1800

atggcgcgat cttggctcat tgcaacctcc gcctcctggg ttcaagcgat tctctgcctc     1860

agcctcccga gttgctggga ttacaggcac acaacttcat gctcagctaa tttttgtatt     1920

ttttagtaga gacagggttt caccatgttg gccaggctgg tctcgaactc ctgccctcag     1980

gtggtccgcc caccttagcc tcccaaagtg ctgggattac aggcgtgagc caccgcgcct     2040

ggcccccatt tgcatcttaa aggtccatct cagatccatt tccatttact gtcctagttc     2100

tggtttggtc cttggcaagt gcactttgcc ttgaacaaaa tagtggcaaa agcttattga     2160

gcaggtactt tgtgccagac actgctcagc atttcatggc attatctcat gaagccccac     2220

gacaattcct ctgaagaaga cacaggcaat tctcattatt cgcgatggtt atgttctata     2280

aaatcacagt gaacattgaa ctagcaaaca gtattaggtt cctgtgagcc tctggtcaca     2340

acattttcat caaccaacag catataatct ggttttatgt atgattctgt ttaaagacat     2400

tttatttagt atatgtgttg ctgattcatc aatgctaagc tgatggcact atagcacaca     2460

cctgaatcaa gtgtctaaca cacgctttct ccctaaggta gccttcttgt gcttaggaac     2520

tacacagctc ttcagcagga ggctcagagg ccatttccaa aagccaaatc cccagcaaaa     2580

gcacaaagtg tgaaaaacgt tgcactaagt agactgagaa ggacactcat tcaataggag     2640

agctgaaaca agcagcagca gcgtgacgcc ttgttgaacc ttaactggga atgtgcaaat     2700

ttttcactgc tctgtgcatg cccacaaatg gccatgaaaa catttcaagt attgacttgg     2760

gagttacaaa taaaattcag caagtaggca cattctcaat gtagaaccag agaagaatga     2820

ggatcaactg tactattatt actgccgttt tacagataag gaaaccaagg ctcagatcag     2880

agtggttaac agtgacttca acattcaaca agtattatta agtgcctact ttgtggcaag     2940

tgctcttcct ggccttggga ctgaagactt acccaaggtc acacagctag caggttgtgg     3000

agtcaggagt ctactccagc tatctgactc ctgaacccaa gttttttttt ttttctttaa     3060

gatggagtct cactctgtca cccaggctgg agtgcagtgg cgcgatctcg gctcactgca     3120

agctccgcct cccgggttca caccattctc ctgcctcggc ctcccgagta gctgggacta     3180

caggcacctg ccaccacccc cagctaattt ttttgtattt ttagtagaga gggggtttca     3240

ctgtattagc caggatggtc ttgatctcct gacctcgtga tctgcccgcc ttggcctccc     3300

aaagtgctgg gattacaggc ttgagccacc gcgcccggcc ctgaacccaa cttttagagc     3360

agaaagtgtt ttcaatgcac agcgaccttt ttgagggtct gtccttttcc tgaccagacc     3420

ctgagggaca gtgcctgagc agttgagtac aggggaagtc ctcagagagt gtgttgtccc     3480

tgcagttctc actgtcaccg gggagccctg ccacttcccc ttccagtacc accggcagct     3540

gtaccacaaa tgtacccaca agggccggcc aggccctcag ccctggtaag actacgcaga     3600

ggagttggag caggggcctg ggagacatgt accctgcctg tccttctgtc caaggaactc     3660

tgcttggaga gaggggactg tgatagggca gggtgggcca ggcccctggg tagagcaggg     3720

aagccttgtc tctttctaca ggtgtgctac cacccccaac tttgatcagg accagcgatg     3780

gggatactgt ttggagccca agaaagtgaa aggtgctaca cacagcctct ggggtggcct     3840

ggggctctct cctcccgcct cattactctc ctggtatcac cagaccccac acactcgaga     3900

taacttcgta taatgtatgc tatacgaagt tatatgcatg ccagtagcag cacccacgtc     3960

caccttctgt ctagtaatgt ccaacacctc cctcagtcca aacactgctc tgcatccatg     4020

tggctcccat ttatacctga agcacttgat ggggcctcaa tgttttacta gagcccaccc     4080

ccctgcaact ctgagaccct ctggatttgt ctgtcagtgc ctcactgggg cgttggataa     4140

tttcttaaaa ggtcaagttc cctcagcagc attctctgag cagtctgaag atgtgtgctt     4200

ttcacagttc aaatccatgt ggctgtttca cccacctgcc tggccttggg ttatctatca     4260

ggacctagcc tagaagcagg tgtgtggcac ttaacaccta agctgagtga ctaactgaac     4320

actcaagtgg atgccatctt tgtcacttct tgactgtgac acaagcaact cctgatgcca     4380

aagccctgcc cacccctctc atgcccatat ttggacatgg tacaggtcct cactggccat     4440

ggtctgtgag gtcctggtcc tctttgactt cataattcct aggggccact agtatctata     4500

agaggaagag ggtgctggct cccaggccac agcccacaaa attccacctg ctcacaggtt     4560

ggctggctcg acccaggtgg tgtcccctgc tctgagccag ctcccggcca agccagcacc     4620

atgggaaccc ccaagaagaa gaggaaggtg cgtaccgatt taaattccaa tttactgacc     4680

gtacaccaaa atttgcctgc attaccggtc gatgcaacga gtgatgaggt tcgcaagaac     4740

ctgatggaca tgttcaggga tcgccaggcg ttttctgagc atacctggaa aatgcttctg     4800

tccgtttgcc ggtcgtgggc ggcatggtgc aagttgaata accggaaatg gtttcccgca     4860

gaacctgaag atgttcgcga ttatcttcta tatcttcagg cgcgcggtct ggcagtaaaa     4920

actatccagc aacatttggg ccagctaaac atgcttcatc gtcggtccgg gctgccacga     4980

ccaagtgaca gcaatgctgt ttcactggtt atgcggcgga tccgaaaaga aaacgttgat     5040

gccggtgaac gtgcaaaaca ggtaaatata aaatttttaa gtgtataatg atgttaaact     5100

actgattcta attgtttgtg tattttaggc tctagcgttc gaacgcactg atttcgacca     5160

ggttcgttca ctcatggaaa atagcgatcg ctgccaggat atacgtaatc tggcatttct     5220

ggggattgct tataacaccc tgttacgtat agccgaaatt gccaggatca gggttaaaga     5280

tatctcacgt actgacggtg ggagaatgtt aatccatatt ggcagaacga aaacgctggt     5340

tagcaccgca ggtgtagaga aggcacttag cctgggggta actaaactgg tcgagcgatg     5400

gatttccgtc tctggtgtag ctgatgatcc gaataactac ctgttttgcc gggtcagaaa     5460

aaatggtgtt gccgcgccat ctgccaccag ccagctatca actcgcgccc tggaagggat     5520

ttttgaagca actcatcgat tgatttacgg cgctaaggat gactctggtc agagatacct     5580

ggcctggtct ggacacagtg cccgtgtcgg agccgcgcga gatatggccc gcgctggagt     5640

ttcaataccg gagatcatgc aagctggtgg ctggaccaat gtaaatattg tcatgaacta     5700

tatccgtaac ctggatagtg aaacaggggc aatggtgcgc ctgctggaag atggcgatta     5760

ggcggccggc cgctaatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac     5820

ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg     5880

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     5940

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     6000

gtctggatcc cccggctaga gtttaaacac tagaactagt ggatcccccg ggatcatggc     6060

ctccgcgccg ggttttggcg cctcccgcgg gcgcccccct cctcacggcg agcgctgcca     6120

cgtcagacga agggcgcagc gagcgtcctg atccttccgc ccggacgctc aggacagcgg     6180

cccgctgctc ataagactcg gccttagaac cccagtatca gcagaaggac attttaggac     6240

gggacttggg tgactctagg gcactggttt tctttccaga gagcggaaca ggcgaggaaa     6300

agtagtccct tctcggcgat tctgcggagg gatctccgtg gggcggtgaa cgccgatgat     6360

tatataagga cgcgccgggt gtggcacagc tagttccgtc gcagccggga tttgggtcgc     6420

ggttcttgtt tgtggatcgc tgtgatcgtc acttggtgag tagcgggctg ctgggctggc     6480

cggggctttc gtggccgccg ggccgctcgg tgggacggaa gcgtgtggag agaccgccaa     6540

gggctgtagt ctgggtccgc gagcaaggtt gccctgaact gggggttggg gggagcgcag     6600

caaaatggcg gctgttcccg agtcttgaat ggaagacgct tgtgaggcgg gctgtgaggt     6660

cgttgaaaca aggtgggggg catggtgggc ggcaagaacc caaggtcttg aggccttcgc     6720

taatgcggga aagctcttat tcgggtgaga tgggctgggg caccatctgg ggaccctgac     6780

gtgaagtttg tcactgactg gagaactcgg tttgtcgtct gttgcggggg cggcagttat     6840

ggcggtgccg ttgggcagtg cacccgtacc tttgggagcg cgcgccctcg tcgtgtcgtg     6900

acgtcacccg ttctgttggc ttataatgca gggtggggcc acctgccggt aggtgtgcgg     6960

taggcttttc tccgtcgcag gacgcagggt tcgggcctag ggtaggctct cctgaatcga     7020

caggcgccgg acctctggtg aggggaggga taagtgaggc gtcagtttct ttggtcggtt     7080

ttatgtacct atcttcttaa gtagctgaag ctccggtttt gaactatgcg ctcggggttg     7140

gcgagtgtgt tttgtgaagt tttttaggca ccttttgaaa tgtaatcatt tgggtcaata     7200

tgtaattttc agtgttagac tagtaaattg tccgctaaat tctggccgtt tttggctttt     7260

ttgttagacg tgttgacaat taatcatcgg catagtatat cggcatagta taatacgaca     7320

aggtgaggaa ctaaaccatg ggatcggcca ttgaacaaga tggattgcac gcaggttctc     7380

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     7440

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     7500

acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca     7560

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     7620

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     7680

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     7740

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     7800

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     7860

ccaggctcaa ggcgcgcatg cccgacggcg atgatctcgt cgtgacccat ggcgatgcct     7920

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     7980

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     8040

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     8100

agcgcatcgc cttctatcgc cttcttgacg agttcttctg aggggatccg ctgtaagtct     8160

gcagaaattg atgatctatt aaacaataaa gatgtccact aaaatggaag tttttcctgt     8220

catactttgt taagaagggt gagaacagag tacctacatt ttgaatggaa ggattggagc     8280

tacgggggtg ggggtggggt gggattagat aaatgcctgc tctttactga aggctcttta     8340

ctattgcttt atgataatgt ttcatagttg gatatcataa tttaaacaag caaaaccaaa     8400

ttaagggcca gctcattcct cccactcatg atctatagat ctatagatct ctcgtgggat     8460

cattgttttt ctcttgattc ccactttgtg gttctaagta ctgtggtttc caaatgtgtc     8520

agtttcatag cctgaagaac gagatcagca gcctctgttc cacatacact tcattctcag     8580

tattgttttg ccaagttcta attccatcag acctcgacct gcagccccta gataacttcg     8640

tataatgtat gctatacgaa gttatgctag gtaactataa cggtcctaag gtagcgagct     8700

agccctggga ttctggaccc agccccttct ctccctccac aatacccttt ggaagtccag     8760

agggagagtt ctgggaagga gtggtcccat tttgcaggtg ggtaaaccaa gcttggaaac     8820

ttggagtagc aaggtcacaa ggcaagtagg ttcaagaagg gccttggccc ccagctgtgt     8880

gactcagctc cctgctcttc cttccaccat gtccatctct cagaccactg cagcaaacac     8940

agcccctgcc agaaaggagg gacctgtgtg aacatgccaa gcggccccca ctgtctctgt     9000

ccacaacacc tcactggaaa ccactgccag aaaggtgagg agatgtggag gacctgggcg     9060

gggtgctggg ggacaggggc aaccctgggc ctacagaata ggttgctgga tactcggaga     9120

cttggcatgg tcctagactc tcctgagacc actatccctc tttgtcccca gagaagtgct     9180

ttgagcctca gcttctccgg tttttccaca agaatgagat atggtataga actgagcaag     9240

cagctgtggc cagatgccag tgcaagggtc ctgatgccca ctgccagcgg ctggccagcc     9300

agggtgagca gatggttggg aacgggccag ggaggagcgt caggaagaca ggctggcagg     9360

aggccgggtg gtgtgccagg aaggagagct ctctgggggg gtctttaggc ccaggggtgg     9420

ctcactgcgt tccctcccca agcctgccgc accaacccgt gcctccatgg gggtcgctgc     9480

ctagaggtgg agggccaccg cctgtgccac tgcccggtgg gctacaccgg acccttctgc     9540

gacgtgggtg agtgagggtc tggggcaagc agaaggccag cccccaggtg ggacgggctt     9600

gccaggaagg aggagggaga gtgcggaaag cagatgagag ggaggcagga gagcccagcc     9660

ttggctgccc agggagcccc ctttctcctc agacaccaag gcaagctgct atgatggccg     9720

cgggctcagc taccgcggcc tggccaggac cacgctctcg ggtgcgccct gtcagccgtg     9780

ggcctcggag gccacctacc ggaacgtgac tgccgagcaa gcgcggaact ggggactggg     9840

cggccacgcc ttctgccggt gcgccgcgtg gggctgggtg acccctccgc cccagggctc     9900

cgggctcccg gcgctctaac ggcgccccgt cgtgtggcta caggaacccg gacaacgaca     9960

tccgcccgtg gtgcttcgtg ctgaaccgcg accggctgag ctgggagtac tgcgacctgg    10020

cacagtgcca gaccccaacc caggcggcgc ctccgacccc ggtgtcccct aggcttcatg    10080

tcccactcat gcccgcgcag ccggcaccgc cgaagcctca gcccacgacc cggaccccgc    10140

ctcagtccca gaccccggga ggttaggaag tggggggggg aaggaggagc cgagagggcg    10200

ccgggcgagc tagattccgg ccagccggcc gcgggctctc cgtcctcagc ccctgctcct    10260

ccacagcctt gccggcgaag cgggagcagc cgccttccct gaccaggaac ggcccactga    10320

gctgcgggca gcggctccgc aagagtctgt cttcgatgac ccgcgtcgtt ggcgggctgg    10380

tggcgctacg cggggcgcac ccctacatcg ccgcgctgta ctggggccac agtttctgcg    10440

ccggcagcct catcgccccc tgctgggtgc tgacggccgc tcactgcctg caggaccggc    10500

gagtacccgc ccgcccagag ccgccccagg ggccgcggct cctccgtctc ccagcgcagc    10560

ttccacgctg cacccgaacc cgtgccctac cttctcccgc cccacccttc tttccacgcc    10620

cctccggagc tcccggggag gaagctggaa cacgggattg gggttcggga gcagggggct    10680

tccccagaac gcttgtggcc aggtctgaga gcgctgcctc tcccctaccc cccccgcagg    10740

cccgcacccg aggatctgac ggtggtgctc ggccaggaac gccgtaacca cagctgtgag    10800

ccgtgccaga cgttggccgt gcgctcctac cgcttgcacg aggccttctc gcccgtcagc    10860

taccagcacg acctgggtgc gtgggggcgc cccgcgggga cgggaagaga gcttggggcc    10920

ccggcgtccc cgcctcacgc tcctctccgc ccgggttagc tctgttgcgc cttcaggagg    10980

atgcggacgg cagctgcgcg ctcctgtcgc cttacgttca gccggtgtgc ctgccaagcg    11040

gcgccgcgcg accctccgag accacgctct gccaggtggc cggctggggc caccagttcg    11100

agggtaggca caactgctag gggcaggggt aggggaggag acctttgatc actgggttag    11160

gcggaagaag cccgcgactt tggtatcgtt ccgggtgcct acagaatggg tggcgctgac    11220

ctgatgggtt gtgagaatgt gtaggtgaat cccaggtaga atcccagggc ctgggattca    11280

ctgctgggat ccccaaatct cctggggata cagggagaat cgaacttgct cttggttccc    11340

tctgggcgcc gggctgcaaa ggccaactag gacgctggcc ccgcgctccg ggctagtgtg    11400

ggagccaggt tctgcgactc tggatgggtg gtgggggagg ggtttctgtt tccgctccgc    11460

ccattcaaat cctggctttt ctctggacct cagcctcctt gcctatgaaa ttgaattaat    11520

ggcacctcct ccccttcggg cttgctgcga gagaggaagg gcatgagtgg gtttacaagc    11580

gcctggagca gctttgtcca tcgtccgggc ggcaagcgtt gtcagatggg gtgtgaagaa    11640

ggcgctctgt gttcgcaggg gcggaggaat atgccagctt cctgcaggag gcgcaggtac    11700

cgttcctctc cctggagcgc tgctcagccc cggacgtgca cggatcctcc atcctccccg    11760

gcatgctctg cgcagggttc ctcgagggcg gcaccgatgc gtgccaggtg agctcttagc    11820

ccggttggcg cccttccccg aggccgtcag gcacaaatct caggtccaca gcgctgagct    11880

gcgtgtttcc gacccagggt gattccggag gcccgctggt gtgtgaggac caagctgcag    11940

agcgccggct caccctgcaa ggcatcatca gctggggatc gggctgtggt gaccgcaaca    12000

agccaggcgt ctacaccgat gtggcctact acctggcctg gatccgggag cacaccgttt    12060

cctgactaac caggctttat ccttccctcc ttgtgtgctc cttgggatgg gacgatgaat    12120

gtggcatgct gggtcacagt gaagctagtg ccccgacact gggggcacag aaactc        12176


<210>  18
<211>  7444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (20)..(3893)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  Start Codon

<220>
<221>  misc_feature
<222>  (3742)..(3812)
<223>  Exon 4

<220>
<221>  misc_feature
<222>  (3894)..(3971)
<223>  Deleted Neo Self-Deleting Cassette

<220>
<221>  misc_feature
<222>  (3894)..(3899)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (3900)..(3933)
<223>  LoxP

<220>
<221>  misc_feature
<222>  (3940)..(3965)
<223>  I_Ceu

<220>
<221>  misc_feature
<222>  (3966)..(3971)
<223>  NheI

<220>
<221>  misc_feature
<222>  (3972)..(7333)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (4192)..(4302)
<223>  Exon 5

<220>
<221>  misc_feature
<222>  (4440)..(4571)
<223>  Exon 6

<220>
<221>  misc_feature
<222>  (4711)..(4815)
<223>  Exon 7

<220>
<221>  misc_feature
<222>  (7331)..(7333)
<223>  Stop Codon

<220>
<221>  misc_feature
<222>  (7334)..(7444)
<223>  Mouse Sequence

<400>  18
ggggccatcg gcagacgcca tgagggctct gctgctcctg gggttcctgc tggtgagctt       60

ggagtcaaca ctttcggtga gtgctgtggg aaccaggatt gtcccaggat tgttctgggg      120

ggtcgctatc acagccatga gccatggcct ctgctcatga cctgtgggtc caggtgacta      180

ggaggcctat gtggaaaggt gaggccagcc cggaaggccc aggcagagga gacagacaac      240

cagactgggt ggatacaagg gcacagcctg catttctggg ggagatgggc cttaagaaga      300

caacgggggg aggtagaaag ggtttgggtc ttgggaagaa atctctgcat ttctgggctg      360

tgagaggaag ctgcagacta gcaacagatc ggtggcaggc tatgacttat agtcagttcc      420

ctgccttctt ctctcccttg tagattccac cttgggaagc ccccaaggag cataagtaca      480

aagctgaaga gcacacagtc ggtaagtggc ctggctcctc ctcccgggaa cccttgggtg      540

gggatgtgta tggtgcagtg tgtgcagtct cagggcagtc tagtctagtg cctacctggt      600

gctaggtctt atgcccatgg gcactagagt gatcgtgagc tgtgtgatcc ttgagggcag      660

ggtatgggct gtgtctaagt gcccacgagc ctggctcgga gcaggtgctt gagatatgtg      720

ctgctggcgc catcacacct gggctcctgc cagccttcct cagtttcccc agcttctccc      780

cttcttttcc tttccccagt acgtctcatg ggcatcattc atgccacaca gaggccaggg      840

ccttcaatgg gcaaggaagg atcaagagct tgtctctggc atctgaatgc ctctgaagcc      900

cagctttatc acttatgagc tgggtgactc tgggcgaggg atttgagttc tccaagcttc      960

aatttcccct tctgtgaaac caggttgata acagtaaacc tcttagggtt gttgagaagg     1020

gaaacccatg tgaggtattc agcccatcac ctggtgcatg gaaatgcttt acaaatatta     1080

gcttttatta tgaaactacc ttttagatga agggtacctg ccatttcccc cttcctcaag     1140

ctctgccata gctccccatt gctttcattc ttccagacac taaattacct acatgccagg     1200

catggtggct catgcctgta atcccagcac tttgggaggc caaggtcggt ggatcatgag     1260

gtcaggagtt cgagaccagc ctggccaaca tggtgaaatg ctgtctctac taaaagtaca     1320

aaaattagcc aggcatggtg gcatgcgcca gtagtcccag ctactcggga ggctgaggca     1380

gaagaattgc ttgaacctgg gaggtgaagg ttgcagtgaa cgaagatcac accattgcac     1440

tccagcttgg gcaacacagc aagactccgt ctcaaaaaaa aaaaaaaaat ttacctagag     1500

tgtggcacat agcagggcct gtgaaccaga tggaccttac cctggtgggc ctgacttggt     1560

ggggttgagt ctctaagcat ggcgttgagg cccagcacat tccaaccctg gactccctca     1620

gcctcctctc ttcaccccac acccaaaagt ttctcctctc tcttgcctta cccaaacttg     1680

gtgccctatc cttgcctaat cccctgccta aggtccccct cctctctgtc cgtccatccc     1740

atctgcatct tttttttttt ttgagatgga gtctcgctct gtcccctagg ctagagtgca     1800

atggcgcgat cttggctcat tgcaacctcc gcctcctggg ttcaagcgat tctctgcctc     1860

agcctcccga gttgctggga ttacaggcac acaacttcat gctcagctaa tttttgtatt     1920

ttttagtaga gacagggttt caccatgttg gccaggctgg tctcgaactc ctgccctcag     1980

gtggtccgcc caccttagcc tcccaaagtg ctgggattac aggcgtgagc caccgcgcct     2040

ggcccccatt tgcatcttaa aggtccatct cagatccatt tccatttact gtcctagttc     2100

tggtttggtc cttggcaagt gcactttgcc ttgaacaaaa tagtggcaaa agcttattga     2160

gcaggtactt tgtgccagac actgctcagc atttcatggc attatctcat gaagccccac     2220

gacaattcct ctgaagaaga cacaggcaat tctcattatt cgcgatggtt atgttctata     2280

aaatcacagt gaacattgaa ctagcaaaca gtattaggtt cctgtgagcc tctggtcaca     2340

acattttcat caaccaacag catataatct ggttttatgt atgattctgt ttaaagacat     2400

tttatttagt atatgtgttg ctgattcatc aatgctaagc tgatggcact atagcacaca     2460

cctgaatcaa gtgtctaaca cacgctttct ccctaaggta gccttcttgt gcttaggaac     2520

tacacagctc ttcagcagga ggctcagagg ccatttccaa aagccaaatc cccagcaaaa     2580

gcacaaagtg tgaaaaacgt tgcactaagt agactgagaa ggacactcat tcaataggag     2640

agctgaaaca agcagcagca gcgtgacgcc ttgttgaacc ttaactggga atgtgcaaat     2700

ttttcactgc tctgtgcatg cccacaaatg gccatgaaaa catttcaagt attgacttgg     2760

gagttacaaa taaaattcag caagtaggca cattctcaat gtagaaccag agaagaatga     2820

ggatcaactg tactattatt actgccgttt tacagataag gaaaccaagg ctcagatcag     2880

agtggttaac agtgacttca acattcaaca agtattatta agtgcctact ttgtggcaag     2940

tgctcttcct ggccttggga ctgaagactt acccaaggtc acacagctag caggttgtgg     3000

agtcaggagt ctactccagc tatctgactc ctgaacccaa gttttttttt ttttctttaa     3060

gatggagtct cactctgtca cccaggctgg agtgcagtgg cgcgatctcg gctcactgca     3120

agctccgcct cccgggttca caccattctc ctgcctcggc ctcccgagta gctgggacta     3180

caggcacctg ccaccacccc cagctaattt ttttgtattt ttagtagaga gggggtttca     3240

ctgtattagc caggatggtc ttgatctcct gacctcgtga tctgcccgcc ttggcctccc     3300

aaagtgctgg gattacaggc ttgagccacc gcgcccggcc ctgaacccaa cttttagagc     3360

agaaagtgtt ttcaatgcac agcgaccttt ttgagggtct gtccttttcc tgaccagacc     3420

ctgagggaca gtgcctgagc agttgagtac aggggaagtc ctcagagagt gtgttgtccc     3480

tgcagttctc actgtcaccg gggagccctg ccacttcccc ttccagtacc accggcagct     3540

gtaccacaaa tgtacccaca agggccggcc aggccctcag ccctggtaag actacgcaga     3600

ggagttggag caggggcctg ggagacatgt accctgcctg tccttctgtc caaggaactc     3660

tgcttggaga gaggggactg tgatagggca gggtgggcca ggcccctggg tagagcaggg     3720

aagccttgtc tctttctaca ggtgtgctac cacccccaac tttgatcagg accagcgatg     3780

gggatactgt ttggagccca agaaagtgaa aggtgctaca cacagcctct ggggtggcct     3840

ggggctctct cctcccgcct cattactctc ctggtatcac cagaccccac acactcgaga     3900

taacttcgta taatgtatgc tatacgaagt tatgctaggt aactataacg gtcctaaggt     3960

agcgagctag ccctgggatt ctggacccag ccccttctct ccctccacaa taccctttgg     4020

aagtccagag ggagagttct gggaaggagt ggtcccattt tgcaggtggg taaaccaagc     4080

ttggaaactt ggagtagcaa ggtcacaagg caagtaggtt caagaagggc cttggccccc     4140

agctgtgtga ctcagctccc tgctcttcct tccaccatgt ccatctctca gaccactgca     4200

gcaaacacag cccctgccag aaaggaggga cctgtgtgaa catgccaagc ggcccccact     4260

gtctctgtcc acaacacctc actggaaacc actgccagaa aggtgaggag atgtggagga     4320

cctgggcggg gtgctggggg acaggggcaa ccctgggcct acagaatagg ttgctggata     4380

ctcggagact tggcatggtc ctagactctc ctgagaccac tatccctctt tgtccccaga     4440

gaagtgcttt gagcctcagc ttctccggtt tttccacaag aatgagatat ggtatagaac     4500

tgagcaagca gctgtggcca gatgccagtg caagggtcct gatgcccact gccagcggct     4560

ggccagccag ggtgagcaga tggttgggaa cgggccaggg aggagcgtca ggaagacagg     4620

ctggcaggag gccgggtggt gtgccaggaa ggagagctct ctgggggggt ctttaggccc     4680

aggggtggct cactgcgttc cctccccaag cctgccgcac caacccgtgc ctccatgggg     4740

gtcgctgcct agaggtggag ggccaccgcc tgtgccactg cccggtgggc tacaccggac     4800

ccttctgcga cgtgggtgag tgagggtctg gggcaagcag aaggccagcc cccaggtggg     4860

acgggcttgc caggaaggag gagggagagt gcggaaagca gatgagaggg aggcaggaga     4920

gcccagcctt ggctgcccag ggagccccct ttctcctcag acaccaaggc aagctgctat     4980

gatggccgcg ggctcagcta ccgcggcctg gccaggacca cgctctcggg tgcgccctgt     5040

cagccgtggg cctcggaggc cacctaccgg aacgtgactg ccgagcaagc gcggaactgg     5100

ggactgggcg gccacgcctt ctgccggtgc gccgcgtggg gctgggtgac ccctccgccc     5160

cagggctccg ggctcccggc gctctaacgg cgccccgtcg tgtggctaca ggaacccgga     5220

caacgacatc cgcccgtggt gcttcgtgct gaaccgcgac cggctgagct gggagtactg     5280

cgacctggca cagtgccaga ccccaaccca ggcggcgcct ccgaccccgg tgtcccctag     5340

gcttcatgtc ccactcatgc ccgcgcagcc ggcaccgccg aagcctcagc ccacgacccg     5400

gaccccgcct cagtcccaga ccccgggagg ttaggaagtg ggggggggaa ggaggagccg     5460

agagggcgcc gggcgagcta gattccggcc agccggccgc gggctctccg tcctcagccc     5520

ctgctcctcc acagccttgc cggcgaagcg ggagcagccg ccttccctga ccaggaacgg     5580

cccactgagc tgcgggcagc ggctccgcaa gagtctgtct tcgatgaccc gcgtcgttgg     5640

cgggctggtg gcgctacgcg gggcgcaccc ctacatcgcc gcgctgtact ggggccacag     5700

tttctgcgcc ggcagcctca tcgccccctg ctgggtgctg acggccgctc actgcctgca     5760

ggaccggcga gtacccgccc gcccagagcc gccccagggg ccgcggctcc tccgtctccc     5820

agcgcagctt ccacgctgca cccgaacccg tgccctacct tctcccgccc cacccttctt     5880

tccacgcccc tccggagctc ccggggagga agctggaaca cgggattggg gttcgggagc     5940

agggggcttc cccagaacgc ttgtggccag gtctgagagc gctgcctctc ccctaccccc     6000

cccgcaggcc cgcacccgag gatctgacgg tggtgctcgg ccaggaacgc cgtaaccaca     6060

gctgtgagcc gtgccagacg ttggccgtgc gctcctaccg cttgcacgag gccttctcgc     6120

ccgtcagcta ccagcacgac ctgggtgcgt gggggcgccc cgcggggacg ggaagagagc     6180

ttggggcccc ggcgtccccg cctcacgctc ctctccgccc gggttagctc tgttgcgcct     6240

tcaggaggat gcggacggca gctgcgcgct cctgtcgcct tacgttcagc cggtgtgcct     6300

gccaagcggc gccgcgcgac cctccgagac cacgctctgc caggtggccg gctggggcca     6360

ccagttcgag ggtaggcaca actgctaggg gcaggggtag gggaggagac ctttgatcac     6420

tgggttaggc ggaagaagcc cgcgactttg gtatcgttcc gggtgcctac agaatgggtg     6480

gcgctgacct gatgggttgt gagaatgtgt aggtgaatcc caggtagaat cccagggcct     6540

gggattcact gctgggatcc ccaaatctcc tggggataca gggagaatcg aacttgctct     6600

tggttccctc tgggcgccgg gctgcaaagg ccaactagga cgctggcccc gcgctccggg     6660

ctagtgtggg agccaggttc tgcgactctg gatgggtggt gggggagggg tttctgtttc     6720

cgctccgccc attcaaatcc tggcttttct ctggacctca gcctccttgc ctatgaaatt     6780

gaattaatgg cacctcctcc ccttcgggct tgctgcgaga gaggaagggc atgagtgggt     6840

ttacaagcgc ctggagcagc tttgtccatc gtccgggcgg caagcgttgt cagatggggt     6900

gtgaagaagg cgctctgtgt tcgcaggggc ggaggaatat gccagcttcc tgcaggaggc     6960

gcaggtaccg ttcctctccc tggagcgctg ctcagccccg gacgtgcacg gatcctccat     7020

cctccccggc atgctctgcg cagggttcct cgagggcggc accgatgcgt gccaggtgag     7080

ctcttagccc ggttggcgcc cttccccgag gccgtcaggc acaaatctca ggtccacagc     7140

gctgagctgc gtgtttccga cccagggtga ttccggaggc ccgctggtgt gtgaggacca     7200

agctgcagag cgccggctca ccctgcaagg catcatcagc tggggatcgg gctgtggtga     7260

ccgcaacaag ccaggcgtct acaccgatgt ggcctactac ctggcctgga tccgggagca     7320

caccgtttcc tgactaacca ggctttatcc ttccctcctt gtgtgctcct tgggatggga     7380

cgatgaatgt ggcatgctgg gtcacagtga agctagtgcc ccgacactgg gggcacagaa     7440

actc                                                                  7444


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
tcggtggcag gctatgactt atag                                              24


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
cagttccctg ccttcttctc tccc                                              24


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ggcttcccaa ggtggaatct ac                                                22


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
aagggcatga gtgggtttac aag                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
cgcctggagc agctttgtcc atc                                               23


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
acacagagcg ccttcttcac a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
gttcctgcct tctctctcct a                                                 21


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
taggctccac catggaaaga ctcca                                             25


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
cccatcaggt gcgtcctta                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
tcgctgctcc aactctaacg                                                   20


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
acgccattct ccctgggatg ctt                                               23


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
atcggtgcct ccctccaaga ag                                                22


<210>  31
<211>  3874
<212>  DNA
<213>  Homo sapiens

<400>  31
atgagggctc tgctgctcct ggggttcctg ctggtgagct tggagtcaac actttcggtg       60

agtgctgtgg gaaccaggat tgtcccagga ttgttctggg gggtcgctat cacagccatg      120

agccatggcc tctgctcatg acctgtgggt ccaggtgact aggaggccta tgtggaaagg      180

tgaggccagc ccggaaggcc caggcagagg agacagacaa ccagactggg tggatacaag      240

ggcacagcct gcatttctgg gggagatggg ccttaagaag acaacggggg gaggtagaaa      300

gggtttgggt cttgggaaga aatctctgca tttctgggct gtgagaggaa gctgcagact      360

agcaacagat cggtggcagg ctatgactta tagtcagttc cctgccttct tctctccctt      420

gtagattcca ccttgggaag cccccaagga gcataagtac aaagctgaag agcacacagt      480

cggtaagtgg cctggctcct cctcccggga acccttgggt ggggatgtgt atggtgcagt      540

gtgtgcagtc tcagggcagt ctagtctagt gcctacctgg tgctaggtct tatgcccatg      600

ggcactagag tgatcgtgag ctgtgtgatc cttgagggca gggtatgggc tgtgtctaag      660

tgcccacgag cctggctcgg agcaggtgct tgagatatgt gctgctggcg ccatcacacc      720

tgggctcctg ccagccttcc tcagtttccc cagcttctcc ccttcttttc ctttccccag      780

tacgtctcat gggcatcatt catgccacac agaggccagg gccttcaatg ggcaaggaag      840

gatcaagagc ttgtctctgg catctgaatg cctctgaagc ccagctttat cacttatgag      900

ctgggtgact ctgggcgagg gatttgagtt ctccaagctt caatttcccc ttctgtgaaa      960

ccaggttgat aacagtaaac ctcttagggt tgttgagaag ggaaacccat gtgaggtatt     1020

cagcccatca cctggtgcat ggaaatgctt tacaaatatt agcttttatt atgaaactac     1080

cttttagatg aagggtacct gccatttccc ccttcctcaa gctctgccat agctccccat     1140

tgctttcatt cttccagaca ctaaattacc tacatgccag gcatggtggc tcatgcctgt     1200

aatcccagca ctttgggagg ccaaggtcgg tggatcatga ggtcaggagt tcgagaccag     1260

cctggccaac atggtgaaat gctgtctcta ctaaaagtac aaaaattagc caggcatggt     1320

ggcatgcgcc agtagtccca gctactcggg aggctgaggc agaagaattg cttgaacctg     1380

ggaggtgaag gttgcagtga acgaagatca caccattgca ctccagcttg ggcaacacag     1440

caagactccg tctcaaaaaa aaaaaaaaaa tttacctaga gtgtggcaca tagcagggcc     1500

tgtgaaccag atggacctta ccctggtggg cctgacttgg tggggttgag tctctaagca     1560

tggcgttgag gcccagcaca ttccaaccct ggactccctc agcctcctct cttcacccca     1620

cacccaaaag tttctcctct ctcttgcctt acccaaactt ggtgccctat ccttgcctaa     1680

tcccctgcct aaggtccccc tcctctctgt ccgtccatcc catctgcatc tttttttttt     1740

tttgagatgg agtctcgctc tgtcccctag gctagagtgc aatggcgcga tcttggctca     1800

ttgcaacctc cgcctcctgg gttcaagcga ttctctgcct cagcctcccg agttgctggg     1860

attacaggca cacaacttca tgctcagcta atttttgtat tttttagtag agacagggtt     1920

tcaccatgtt ggccaggctg gtctcgaact cctgccctca ggtggtccgc ccaccttagc     1980

ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc tggcccccat ttgcatctta     2040

aaggtccatc tcagatccat ttccatttac tgtcctagtt ctggtttggt ccttggcaag     2100

tgcactttgc cttgaacaaa atagtggcaa aagcttattg agcaggtact ttgtgccaga     2160

cactgctcag catttcatgg cattatctca tgaagcccca cgacaattcc tctgaagaag     2220

acacaggcaa ttctcattat tcgcgatggt tatgttctat aaaatcacag tgaacattga     2280

actagcaaac agtattaggt tcctgtgagc ctctggtcac aacattttca tcaaccaaca     2340

gcatataatc tggttttatg tatgattctg tttaaagaca ttttatttag tatatgtgtt     2400

gctgattcat caatgctaag ctgatggcac tatagcacac acctgaatca agtgtctaac     2460

acacgctttc tccctaaggt agccttcttg tgcttaggaa ctacacagct cttcagcagg     2520

aggctcagag gccatttcca aaagccaaat ccccagcaaa agcacaaagt gtgaaaaacg     2580

ttgcactaag tagactgaga aggacactca ttcaatagga gagctgaaac aagcagcagc     2640

agcgtgacgc cttgttgaac cttaactggg aatgtgcaaa tttttcactg ctctgtgcat     2700

gcccacaaat ggccatgaaa acatttcaag tattgacttg ggagttacaa ataaaattca     2760

gcaagtaggc acattctcaa tgtagaacca gagaagaatg aggatcaact gtactattat     2820

tactgccgtt ttacagataa ggaaaccaag gctcagatca gagtggttaa cagtgacttc     2880

aacattcaac aagtattatt aagtgcctac tttgtggcaa gtgctcttcc tggccttggg     2940

actgaagact tacccaaggt cacacagcta gcaggttgtg gagtcaggag tctactccag     3000

ctatctgact cctgaaccca agtttttttt tttttcttta agatggagtc tcactctgtc     3060

acccaggctg gagtgcagtg gcgcgatctc ggctcactgc aagctccgcc tcccgggttc     3120

acaccattct cctgcctcgg cctcccgagt agctgggact acaggcacct gccaccaccc     3180

ccagctaatt tttttgtatt tttagtagag agggggtttc actgtattag ccaggatggt     3240

cttgatctcc tgacctcgtg atctgcccgc cttggcctcc caaagtgctg ggattacagg     3300

cttgagccac cgcgcccggc cctgaaccca acttttagag cagaaagtgt tttcaatgca     3360

cagcgacctt tttgagggtc tgtccttttc ctgaccagac cctgagggac agtgcctgag     3420

cagttgagta caggggaagt cctcagagag tgtgttgtcc ctgcagttct cactgtcacc     3480

ggggagccct gccacttccc cttccagtac caccggcagc tgtaccacaa atgtacccac     3540

aagggccggc caggccctca gccctggtaa gactacgcag aggagttgga gcaggggcct     3600

gggagacatg taccctgcct gtccttctgt ccaaggaact ctgcttggag agaggggact     3660

gtgatagggc agggtgggcc aggcccctgg gtagagcagg gaagccttgt ctctttctac     3720

aggtgtgcta ccacccccaa ctttgatcag gaccagcgat ggggatactg tttggagccc     3780

aagaaagtga aaggtgctac acacagcctc tggggtggcc tggggctctc tcctcccgcc     3840

tcattactct cctggtatca ccagacccca caca                                 3874


<210>  32
<211>  3362
<212>  DNA
<213>  Homo sapiens

<400>  32
cctgggattc tggacccagc cccttctctc cctccacaat accctttgga agtccagagg       60

gagagttctg ggaaggagtg gtcccatttt gcaggtgggt aaaccaagct tggaaacttg      120

gagtagcaag gtcacaaggc aagtaggttc aagaagggcc ttggccccca gctgtgtgac      180

tcagctccct gctcttcctt ccaccatgtc catctctcag accactgcag caaacacagc      240

ccctgccaga aaggagggac ctgtgtgaac atgccaagcg gcccccactg tctctgtcca      300

caacacctca ctggaaacca ctgccagaaa ggtgaggaga tgtggaggac ctgggcgggg      360

tgctggggga caggggcaac cctgggccta cagaataggt tgctggatac tcggagactt      420

ggcatggtcc tagactctcc tgagaccact atccctcttt gtccccagag aagtgctttg      480

agcctcagct tctccggttt ttccacaaga atgagatatg gtatagaact gagcaagcag      540

ctgtggccag atgccagtgc aagggtcctg atgcccactg ccagcggctg gccagccagg      600

gtgagcagat ggttgggaac gggccaggga ggagcgtcag gaagacaggc tggcaggagg      660

ccgggtggtg tgccaggaag gagagctctc tgggggggtc tttaggccca ggggtggctc      720

actgcgttcc ctccccaagc ctgccgcacc aacccgtgcc tccatggggg tcgctgccta      780

gaggtggagg gccaccgcct gtgccactgc ccggtgggct acaccggacc cttctgcgac      840

gtgggtgagt gagggtctgg ggcaagcaga aggccagccc ccaggtggga cgggcttgcc      900

aggaaggagg agggagagtg cggaaagcag atgagaggga ggcaggagag cccagccttg      960

gctgcccagg gagccccctt tctcctcaga caccaaggca agctgctatg atggccgcgg     1020

gctcagctac cgcggcctgg ccaggaccac gctctcgggt gcgccctgtc agccgtgggc     1080

ctcggaggcc acctaccgga acgtgactgc cgagcaagcg cggaactggg gactgggcgg     1140

ccacgccttc tgccggtgcg ccgcgtgggg ctgggtgacc cctccgcccc agggctccgg     1200

gctcccggcg ctctaacggc gccccgtcgt gtggctacag gaacccggac aacgacatcc     1260

gcccgtggtg cttcgtgctg aaccgcgacc ggctgagctg ggagtactgc gacctggcac     1320

agtgccagac cccaacccag gcggcgcctc cgaccccggt gtcccctagg cttcatgtcc     1380

cactcatgcc cgcgcagccg gcaccgccga agcctcagcc cacgacccgg accccgcctc     1440

agtcccagac cccgggaggt taggaagtgg gggggggaag gaggagccga gagggcgccg     1500

ggcgagctag attccggcca gccggccgcg ggctctccgt cctcagcccc tgctcctcca     1560

cagccttgcc ggcgaagcgg gagcagccgc cttccctgac caggaacggc ccactgagct     1620

gcgggcagcg gctccgcaag agtctgtctt cgatgacccg cgtcgttggc gggctggtgg     1680

cgctacgcgg ggcgcacccc tacatcgccg cgctgtactg gggccacagt ttctgcgccg     1740

gcagcctcat cgccccctgc tgggtgctga cggccgctca ctgcctgcag gaccggcgag     1800

tacccgcccg cccagagccg ccccaggggc cgcggctcct ccgtctccca gcgcagcttc     1860

cacgctgcac ccgaacccgt gccctacctt ctcccgcccc acccttcttt ccacgcccct     1920

ccggagctcc cggggaggaa gctggaacac gggattgggg ttcgggagca gggggcttcc     1980

ccagaacgct tgtggccagg tctgagagcg ctgcctctcc cctacccccc ccgcaggccc     2040

gcacccgagg atctgacggt ggtgctcggc caggaacgcc gtaaccacag ctgtgagccg     2100

tgccagacgt tggccgtgcg ctcctaccgc ttgcacgagg ccttctcgcc cgtcagctac     2160

cagcacgacc tgggtgcgtg ggggcgcccc gcggggacgg gaagagagct tggggccccg     2220

gcgtccccgc ctcacgctcc tctccgcccg ggttagctct gttgcgcctt caggaggatg     2280

cggacggcag ctgcgcgctc ctgtcgcctt acgttcagcc ggtgtgcctg ccaagcggcg     2340

ccgcgcgacc ctccgagacc acgctctgcc aggtggccgg ctggggccac cagttcgagg     2400

gtaggcacaa ctgctagggg caggggtagg ggaggagacc tttgatcact gggttaggcg     2460

gaagaagccc gcgactttgg tatcgttccg ggtgcctaca gaatgggtgg cgctgacctg     2520

atgggttgtg agaatgtgta ggtgaatccc aggtagaatc ccagggcctg ggattcactg     2580

ctgggatccc caaatctcct ggggatacag ggagaatcga acttgctctt ggttccctct     2640

gggcgccggg ctgcaaaggc caactaggac gctggccccg cgctccgggc tagtgtggga     2700

gccaggttct gcgactctgg atgggtggtg ggggaggggt ttctgtttcc gctccgccca     2760

ttcaaatcct ggcttttctc tggacctcag cctccttgcc tatgaaattg aattaatggc     2820

acctcctccc cttcgggctt gctgcgagag aggaagggca tgagtgggtt tacaagcgcc     2880

tggagcagct ttgtccatcg tccgggcggc aagcgttgtc agatggggtg tgaagaaggc     2940

gctctgtgtt cgcaggggcg gaggaatatg ccagcttcct gcaggaggcg caggtaccgt     3000

tcctctccct ggagcgctgc tcagccccgg acgtgcacgg atcctccatc ctccccggca     3060

tgctctgcgc agggttcctc gagggcggca ccgatgcgtg ccaggtgagc tcttagcccg     3120

gttggcgccc ttccccgagg ccgtcaggca caaatctcag gtccacagcg ctgagctgcg     3180

tgtttccgac ccagggtgat tccggaggcc cgctggtgtg tgaggaccaa gctgcagagc     3240

gccggctcac cctgcaaggc atcatcagct ggggatcggg ctgtggtgac cgcaacaagc     3300

caggcgtcta caccgatgtg gcctactacc tggcctggat ccgggagcac accgtttcct     3360

ga                                                                    3362


<210>  33
<211>  1971
<212>  DNA
<213>  Mus musculus

<400>  33
actcctgggc aggcagcggg gccatcggca gacgccatga cggctctgtt gttcctgggg       60

tctctgctga tgagtctgga tctgacactt tcggctccac catggaaaga ctccaagaaa      120

tttaaggacg cacctgatgg gcccacagtg gttctcactg tggatgggag gctctgccat      180

tttccctttc agtaccaccg tcagctacac cacaaatgca tccacaaaag gcggccaggc      240

tcccgcccct ggtgtgctac cacccccaac tttgatgaag atcagcaatg gggatactgc      300

ttggagccca agaaagtgaa agaccattgc agcaaacaca acccgtgcca caaaggaggg      360

acatgtatca acacccccaa tgggccacac tgtctctgcc ctgaacacct cactgggaaa      420

cattgccaga aagagaaatg ctttgagcct cagcttctca agttcttcca cgagaatgag      480

ctatggttta gaacggggcc aggaggtgtg gccaggtgcg agtgcaaagg ttctgaggct      540

cactgcaagc cggtggccag ccaggcctgc agcatcaatc cgtgccttaa tgggggcagc      600

tgcctcctcg tggaggacca cccactgtgc cgttgcccta caggctacac tggatatttt      660

tgcgacttgg acctttgggc gacctgctat gaaggcaggg ggctcagcta ccggggccag      720

gctggaacta cgcaatcggg tgcgccatgt cagcggtgga ccgtggaggc cacctaccgg      780

aacatgactg agaagcaagc gctaagctgg ggcctgggcc accacgcatt ttgccggaac      840

ccagataatg acacacgtcc atggtgcttc gtctggagtg gcgacaggct gagctgggac      900

tattgcggcc tggagcagtg ccagacgcca acgtttgcac ctctagttgt ccctgagagt      960

caggaggagt ccccgtccca ggcaccatct ctgtcccatg caccaaatga ctcgaccgat     1020

catcagactt ctctgtccaa gaccaacacg atgggctgcg gacagaggtt ccgcaaggga     1080

ctgtcctcgt tcatgcgcgt ggtgggcgga ctagtggctc tgcctgggtc gcacccctac     1140

atcgctgcac tgtactgggg taacaacttc tgcgcgggca gtctcatcgc cccctgttgg     1200

gtgctgaccg cggctcactg cctgcagaat cggccagcgc ccgaggaact gacagtggta     1260

cttggtcaag atcgccacaa ccagagctgc gagtggtgcc agactctggc tgtgcgctcc     1320

taccgccttc acgagggctt ctcctccatc acctaccagc acgacttggc tctgctgcgc     1380

ctgcaggaaa gcaaaaccaa cagttgcgcg atcctgtcac ctcacgttca gcctgtgtgt     1440

ctacccagcg gcgcggcccc accctctgag acagtgctct gcgaggtggc cggctggggt     1500

caccagttcg agggggctga agaatactcc accttcctgc aggaggcaca ggttcccttt     1560

atcgccctgg atcgctgctc caactctaac gtgcacggag acgccattct ccctgggatg     1620

ctttgcgctg gcttcttgga gggaggcacc gatgcctgcc agggtgactc cgggggccct     1680

ctggtgtgtg aggaaggaac tgcagaacat cagctcaccc tgcgcggagt catcagctgg     1740

ggctccggct gtggtgaccg caacaagccc ggagtctaca cagacgtggc caactacctg     1800

gcttggatcc agaagcatat tgcttcataa ctaaccaggc tttatccttc cctccttgtg     1860

tgctccttgg gatgggacga tgaatgtggc atgctgggtc acagtgaagc tagtgccccg     1920

acactggggg cacagaaact caataaagtg ctttgaaaac gttcctcaga a              1971


<210>  34
<211>  2060
<212>  DNA
<213>  Homo sapiens

<400>  34
ctattgatct ggactcctgg ataggcagct ggaccaacgg acggatgcca tgagggctct       60

gctgctcctg gggttcctgc tggtgagctt ggagtcaaca ctttcgattc caccttggga      120

agcccccaag gagcataagt acaaagctga agagcacaca gtcgttctca ctgtcaccgg      180

ggagccctgc cacttcccct tccagtacca ccggcagctg taccacaaat gtacccacaa      240

gggccggcca ggccctcagc cctggtgtgc taccaccccc aactttgatc aggaccagcg      300

atggggatac tgtttggagc ccaagaaagt gaaagaccac tgcagcaaac acagcccctg      360

ccagaaagga gggacctgtg tgaacatgcc aagcggcccc cactgtctct gtccacaaca      420

cctcactgga aaccactgcc agaaagagaa gtgctttgag cctcagcttc tccggttttt      480

ccacaagaat gagatatggt atagaactga gcaagcagct gtggccagat gccagtgcaa      540

gggtcctgat gcccactgcc agcggctggc cagccaggcc tgccgcacca acccgtgcct      600

ccatgggggt cgctgcctag aggtggaggg ccaccgcctg tgccactgcc cggtgggcta      660

caccggagcc ttctgcgacg tggacaccaa ggcaagctgc tatgatggcc gcgggctcag      720

ctaccgcggc ctggccagga ccacgctctc gggtgcgccc tgtcagccgt gggcctcgga      780

ggccacctac cggaacgtga ctgccgagca agcgcggaac tggggactgg gcggccacgc      840

cttctgccgg aacccggaca acgacatccg cccgtggtgc ttcgtgctga accgcgaccg      900

gctgagctgg gagtactgcg acctggcaca gtgccagacc ccaacccagg cggcgcctcc      960

gaccccggtg tcccctaggc ttcatgtccc actcatgccc gcgcagccgg caccgccgaa     1020

gcctcagccc acgacccgga ccccgcctca gtcccagacc ccgggagcct tgccggcgaa     1080

gcgggagcag ccgccttccc tgaccaggaa cggcccactg agctgcgggc agcggctccg     1140

caagagtctg tcttcgatga cccgcgtcgt tggcgggctg gtggcgctac gcggggcgca     1200

cccctacatc gccgcgctgt actggggcca cagtttctgc gccggcagcc tcatcgcccc     1260

ctgctgggtg ctgacggccg ctcactgcct gcaggaccgg cccgcacccg aggatctgac     1320

ggtggtgctc ggccaggaac gccgtaacca cagctgtgag ccgtgccaga cgttggccgt     1380

gcgctcctac cgcttgcacg aggccttctc gcccgtcagc taccagcacg acctggctct     1440

gttgcgcctt caggaggatg cggacggcag ctgcgcgctc ctgtcgcctt acgttcagcc     1500

ggtgtgcctg ccaagcggcg ccgcgcgacc ctccgagacc acgctctgcc aggtggccgg     1560

ctggggccac cagttcgagg gggcggagga atatgccagc ttcctgcagg aggcgcaggt     1620

accgttcctc tccctggagc gctgctcagc cccggacgtg cacggatcct ccatcctccc     1680

cggcatgctc tgcgcagggt tcctcgaggg cggcaccgat gcgtgccagg gtgattccgg     1740

aggcccgctg gtgtgtgagg accaagctgc agagcgccgg ctcaccctgc aaggcatcat     1800

cagctgggga tcgggctgtg gtgaccgcaa caagccaggc gtctacaccg atgtggccta     1860

ctacctggcc tggatccggg agcacaccgt ttcctgattg ctcagggact catctttccc     1920

tccttggtga ttccgcagtg agagagtggc tggggcatgg aaggcaagat tgtgtcccat     1980

tcccccagtg cggccagctc cgcgccagga tggcgcagga actcaataaa gtgctttgaa     2040

aatgctgaga aaaaaaaaaa                                                 2060


<210>  35
<211>  1391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (4)..(10)
<223>  5' NLS

<220>
<221>  MISC_FEATURE
<222>  (1376)..(1391)
<223>  3' NLS

<400>  35

Met Asp Lys Pro Lys Lys Lys Arg Lys Val Lys Tyr Ser Ile Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            20                  25                  30          


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        35                  40                  45              


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    50                  55                  60                  


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
65                  70                  75                  80  


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                85                  90                  95      


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            100                 105                 110         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        115                 120                 125             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    130                 135                 140                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
145                 150                 155                 160 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                165                 170                 175     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            180                 185                 190         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        195                 200                 205             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    210                 215                 220                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
225                 230                 235                 240 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                245                 250                 255     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            260                 265                 270         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        275                 280                 285             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    290                 295                 300                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
305                 310                 315                 320 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                325                 330                 335     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            340                 345                 350         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        355                 360                 365             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    370                 375                 380                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
385                 390                 395                 400 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                405                 410                 415     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            420                 425                 430         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        435                 440                 445             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    450                 455                 460                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
465                 470                 475                 480 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                485                 490                 495     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            500                 505                 510         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    530                 535                 540                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
545                 550                 555                 560 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                565                 570                 575     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            580                 585                 590         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        595                 600                 605             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    610                 615                 620                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
625                 630                 635                 640 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                645                 650                 655     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            660                 665                 670         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        675                 680                 685             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    690                 695                 700                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
705                 710                 715                 720 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            740                 745                 750         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    770                 775                 780                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
785                 790                 795                 800 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                805                 810                 815     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            820                 825                 830         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
        835                 840                 845             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
865                 870                 875                 880 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                885                 890                 895     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
    930                 935                 940                 


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp 
                965                 970                 975     


Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1055                 1060                 1065             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1070                 1075                 1080             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1115                 1120                 1125             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1175                 1180                 1185             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1220                 1225                 1230             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1235                 1240                 1245             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1250                 1255                 1260             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1265                 1270                 1275             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1295                 1300                 1305             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1310                 1315                 1320             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro Ala Ala  Thr Lys Lys 
    1370                 1375                 1380             


Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1385                 1390     


<210>  36
<211>  4176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Start Codon

<220>
<221>  misc_feature
<222>  (10)..(30)
<223>  5' NLS

<220>
<221>  misc_feature
<222>  (4126)..(4173)
<223>  3' NLS

<220>
<221>  misc_feature
<222>  (4174)..(4176)
<223>  Stop Codon

<400>  36
atggacaagc ccaagaaaaa gcggaaagtg aagtacagca tcggcctgga catcggcacc       60

aactctgtgg gctgggccgt gatcaccgac gagtacaagg tgcccagcaa gaaattcaag      120

gtgctgggca acaccgacag gcacagcatc aagaagaacc tgatcggcgc cctgctgttc      180

gacagcggcg aaacagccga ggccaccaga ctgaagagaa ccgccagaag aagatacacc      240

aggcggaaga acaggatctg ctatctgcaa gagatcttca gcaacgagat ggccaaggtg      300

gacgacagct tcttccacag actggaagag tccttcctgg tggaagagga caagaagcac      360

gagagacacc ccatcttcgg caacatcgtg gacgaggtgg cctaccacga gaagtacccc      420

accatctacc acctgagaaa gaaactggtg gacagcaccg acaaggccga cctgagactg      480

atctacctgg ccctggccca catgatcaag ttcagaggcc acttcctgat cgagggcgac      540

ctgaaccccg acaacagcga cgtggacaag ctgttcatcc agctggtgca gacctacaac      600

cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg acgccaaggc tatcctgtct      660

gccagactga gcaagagcag aaggctggaa aatctgatcg cccagctgcc cggcgagaag      720

aagaacggcc tgttcggcaa cctgattgcc ctgagcctgg gcctgacccc caacttcaag      780

agcaacttcg acctggccga ggatgccaaa ctgcagctga gcaaggacac ctacgacgac      840

gacctggaca acctgctggc ccagatcggc gaccagtacg ccgacctgtt cctggccgcc      900

aagaacctgt ctgacgccat cctgctgagc gacatcctga gagtgaacac cgagatcacc      960

aaggcccccc tgagcgcctc tatgatcaag agatacgacg agcaccacca ggacctgacc     1020

ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt acaaagaaat cttcttcgac     1080

cagagcaaga acggctacgc cggctacatc gatggcggcg ctagccagga agagttctac     1140

aagttcatca agcccatcct ggaaaagatg gacggcaccg aggaactgct cgtgaagctg     1200

aacagagagg acctgctgag aaagcagaga accttcgaca acggcagcat cccccaccag     1260

atccacctgg gagagctgca cgctatcctg agaaggcagg aagattttta cccattcctg     1320

aaggacaacc gggaaaagat cgagaagatc ctgaccttca ggatccccta ctacgtgggc     1380

cccctggcca gaggcaacag cagattcgcc tggatgacca gaaagagcga ggaaaccatc     1440

accccctgga acttcgagga agtggtggac aagggcgcca gcgcccagag cttcatcgag     1500

agaatgacaa acttcgataa gaacctgccc aacgagaagg tgctgcccaa gcacagcctg     1560

ctgtacgagt acttcaccgt gtacaacgag ctgaccaaag tgaaatacgt gaccgaggga     1620

atgagaaagc ccgccttcct gagcggcgag cagaaaaagg ccatcgtgga cctgctgttc     1680

aagaccaaca gaaaagtgac cgtgaagcag ctgaaagagg actacttcaa gaaaatcgag     1740

tgcttcgact ccgtggaaat ctccggcgtg gaagatagat tcaacgcctc cctgggcaca     1800

taccacgatc tgctgaaaat tatcaaggac aaggacttcc tggataacga agagaacgag     1860

gacattctgg aagatatcgt gctgaccctg acactgtttg aggaccgcga gatgatcgag     1920

gaaaggctga aaacctacgc tcacctgttc gacgacaaag tgatgaagca gctgaagaga     1980

aggcggtaca ccggctgggg caggctgagc agaaagctga tcaacggcat cagagacaag     2040

cagagcggca agacaatcct ggatttcctg aagtccgacg gcttcgccaa ccggaacttc     2100

atgcagctga tccacgacga cagcctgaca ttcaaagagg acatccagaa agcccaggtg     2160

tccggccagg gcgactctct gcacgagcat atcgctaacc tggccggcag ccccgctatc     2220

aagaagggca tcctgcagac agtgaaggtg gtggacgagc tcgtgaaagt gatgggcaga     2280

cacaagcccg agaacatcgt gatcgagatg gctagagaga accagaccac ccagaaggga     2340

cagaagaact cccgcgagag gatgaagaga atcgaagagg gcatcaaaga gctgggcagc     2400

cagatcctga aagaacaccc cgtggaaaac acccagctgc agaacgagaa gctgtacctg     2460

tactacctgc agaatggccg ggatatgtac gtggaccagg aactggacat caacagactg     2520

tccgactacg atgtggacca tatcgtgcct cagagctttc tgaaggacga ctccatcgat     2580

aacaaagtgc tgactcggag cgacaagaac agaggcaaga gcgacaacgt gccctccgaa     2640

gaggtcgtga agaagatgaa gaactactgg cgacagctgc tgaacgccaa gctgattacc     2700

cagaggaagt tcgataacct gaccaaggcc gagagaggcg gcctgagcga gctggataag     2760

gccggcttca tcaagaggca gctggtggaa accagacaga tcacaaagca cgtggcacag     2820

atcctggact cccggatgaa cactaagtac gacgaaaacg ataagctgat ccgggaagtg     2880

aaagtgatca ccctgaagtc caagctggtg tccgatttcc ggaaggattt ccagttttac     2940

aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg cctacctgaa cgccgtcgtg     3000

ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg agttcgtgta cggcgactac     3060

aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc aggaaatcgg caaggctacc     3120

gccaagtact tcttctacag caacatcatg aactttttca agaccgaaat caccctggcc     3180

aacggcgaga tcagaaagcg ccctctgatc gagacaaacg gcgaaaccgg ggagatcgtg     3240

tgggataagg gcagagactt cgccacagtg cgaaaggtgc tgagcatgcc ccaagtgaat     3300

atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca aagagtctat cctgcccaag     3360

aggaacagcg acaagctgat cgccagaaag aaggactggg accccaagaa gtacggcggc     3420

ttcgacagcc ctaccgtggc ctactctgtg ctggtggtgg ctaaggtgga aaagggcaag     3480

tccaagaaac tgaagagtgt gaaagagctg ctggggatca ccatcatgga aagaagcagc     3540

tttgagaaga accctatcga ctttctggaa gccaagggct acaaagaagt gaaaaaggac     3600

ctgatcatca agctgcctaa gtactccctg ttcgagctgg aaaacggcag aaagagaatg     3660

ctggcctctg ccggcgaact gcagaaggga aacgagctgg ccctgcctag caaatatgtg     3720

aacttcctgt acctggcctc ccactatgag aagctgaagg gcagccctga ggacaacgaa     3780

cagaaacagc tgtttgtgga acagcataag cactacctgg acgagatcat cgagcagatc     3840

agcgagttct ccaagagagt gatcctggcc gacgccaatc tggacaaggt gctgtctgcc     3900

tacaacaagc acagggacaa gcctatcaga gagcaggccg agaatatcat ccacctgttc     3960

accctgacaa acctgggcgc tcctgccgcc ttcaagtact ttgacaccac catcgaccgg     4020

aagaggtaca ccagcaccaa agaggtgctg gacgccaccc tgatccacca gagcatcacc     4080

ggcctgtacg agacaagaat cgacctgtct cagctgggag gcgacaagag acctgccgcc     4140

actaagaagg ccggacaggc caaaaagaag aagtga                               4176


<210>  37
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
guuuuagagc uaugcu                                                       16


<210>  38
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  39
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcu                                                      77


<210>  40
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  41
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  42
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugc                                            86


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  n is a, c, g, or t

<400>  43
gnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n is a, c, g, or t

<400>  44
nnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(23)
<223>  n is a, c, g, or t

<400>  45
ggnnnnnnnn nnnnnnnnnn nnngg                                             25


<210>  46
<211>  615
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (20)..(372)
<223>  Heavy Chain

<220>
<221>  MISC_FEATURE
<222>  (373)..(615)
<223>  Light Chain

<400>  46

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  47
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys Ala Glu Glu 
1               5                   10                  15      


His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His Phe Pro Phe 
            20                  25                  30          


Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys Gly Arg Pro 
        35                  40                  45              


Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp Gln Asp Gln 
    50                  55                  60                  


Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp His Cys Ser 
65                  70                  75                  80  


Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn Met Pro Ser 
                85                  90                  95      


Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn His Cys Gln 
            100                 105                 110         


Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe His Lys Asn 
        115                 120                 125             


Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg Cys Gln Cys 
    130                 135                 140                 


Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln Ala Cys Arg 
145                 150                 155                 160 


Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val Glu Gly His 
                165                 170                 175     


Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe Cys Asp Val 
            180                 185                 190         


Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser Tyr Arg Gly 
        195                 200                 205             


Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro Trp Ala Ser 
    210                 215                 220                 


Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg Asn Trp Gly 
225                 230                 235                 240 


Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp Ile Arg Pro 
                245                 250                 255     


Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu Tyr Cys Asp 
            260                 265                 270         


Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro Thr Pro Val 
        275                 280                 285             


Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro Ala Pro Pro 
    290                 295                 300                 


Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln Thr Pro Gly 
305                 310                 315                 320 


Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr Arg Asn Gly 
                325                 330                 335     


Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser Ser Met Thr 
            340                 345                 350         


Arg 
    


<210>  48
<211>  1848
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (58)..(1116)
<223>  Heavy Chain

<220>
<221>  misc_feature
<222>  (1117)..(1845)
<223>  Light Chain

<400>  48
atgagggctc tgctgctcct ggggttcctg ctggtgagct tggagtcaac actttcgatt       60

ccaccttggg aagcccccaa ggagcataag tacaaagctg aagagcacac agtcgttctc      120

actgtcaccg gggagccctg ccacttcccc ttccagtacc accggcagct gtaccacaaa      180

tgtacccaca agggccggcc aggccctcag ccctggtgtg ctaccacccc caactttgat      240

caggaccagc gatggggata ctgtttggag cccaagaaag tgaaagacca ctgcagcaaa      300

cacagcccct gccagaaagg agggacctgt gtgaacatgc caagcggccc ccactgtctc      360

tgtccacaac acctcactgg aaaccactgc cagaaagaga agtgctttga gcctcagctt      420

ctccggtttt tccacaagaa tgagatatgg tatagaactg agcaagcagc tgtggccaga      480

tgccagtgca agggtcctga tgcccactgc cagcggctgg ccagccaggc ctgccgcacc      540

aacccgtgcc tccatggggg tcgctgccta gaggtggagg gccaccgcct gtgccactgc      600

ccggtgggct acaccggagc cttctgcgac gtggacacca aggcaagctg ctatgatggc      660

cgcgggctca gctaccgcgg cctggccagg accacgctct cgggtgcgcc ctgtcagccg      720

tgggcctcgg aggccaccta ccggaacgtg actgccgagc aagcgcggaa ctggggactg      780

ggcggccacg ccttctgccg gaacccggac aacgacatcc gcccgtggtg cttcgtgctg      840

aaccgcgacc ggctgagctg ggagtactgc gacctggcac agtgccagac cccaacccag      900

gcggcgcctc cgaccccggt gtcccctagg cttcatgtcc cactcatgcc cgcgcagccg      960

gcaccgccga agcctcagcc cacgacccgg accccgcctc agtcccagac cccgggagcc     1020

ttgccggcga agcgggagca gccgccttcc ctgaccagga acggcccact gagctgcggg     1080

cagcggctcc gcaagagtct gtcttcgatg acccgcgtcg ttggcgggct ggtggcgcta     1140

cgcggggcgc acccctacat cgccgcgctg tactggggcc acagtttctg cgccggcagc     1200

ctcatcgccc cctgctgggt gctgacggcc gctcactgcc tgcaggaccg gcccgcaccc     1260

gaggatctga cggtggtgct cggccaggaa cgccgtaacc acagctgtga gccgtgccag     1320

acgttggccg tgcgctccta ccgcttgcac gaggccttct cgcccgtcag ctaccagcac     1380

gacctggctc tgttgcgcct tcaggaggat gcggacggca gctgcgcgct cctgtcgcct     1440

tacgttcagc cggtgtgcct gccaagcggc gccgcgcgac cctccgagac cacgctctgc     1500

caggtggccg gctggggcca ccagttcgag ggggcggagg aatatgccag cttcctgcag     1560

gaggcgcagg taccgttcct ctccctggag cgctgctcag ccccggacgt gcacggatcc     1620

tccatcctcc ccggcatgct ctgcgcaggg ttcctcgagg gcggcaccga tgcgtgccag     1680

ggtgattccg gaggcccgct ggtgtgtgag gaccaagctg cagagcgccg gctcaccctg     1740

caaggcatca tcagctgggg atcgggctgt ggtgaccgca acaagccagg cgtctacacc     1800

gatgtggcct actacctggc ctggatccgg gagcacaccg tttcctga                  1848


<210>  49
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  49
attccacctt gggaagcccc caaggagcat aagtacaaag ctgaagagca cacagtcgtt       60

ctcactgtca ccggggagcc ctgccacttc cccttccagt accaccggca gctgtaccac      120

aaatgtaccc acaagggccg gccaggccct cagccctggt gtgctaccac ccccaacttt      180

gatcaggacc agcgatgggg atactgtttg gagcccaaga aagtgaaaga ccactgcagc      240

aaacacagcc cctgccagaa aggagggacc tgtgtgaaca tgccaagcgg cccccactgt      300

ctctgtccac aacacctcac tggaaaccac tgccagaaag agaagtgctt tgagcctcag      360

cttctccggt ttttccacaa gaatgagata tggtatagaa ctgagcaagc agctgtggcc      420

agatgccagt gcaagggtcc tgatgcccac tgccagcggc tggccagcca ggcctgccgc      480

accaacccgt gcctccatgg gggtcgctgc ctagaggtgg agggccaccg cctgtgccac      540

tgcccggtgg gctacaccgg agccttctgc gacgtggaca ccaaggcaag ctgctatgat      600

ggccgcgggc tcagctaccg cggcctggcc aggaccacgc tctcgggtgc gccctgtcag      660

ccgtgggcct cggaggccac ctaccggaac gtgactgccg agcaagcgcg gaactgggga      720

ctgggcggcc acgccttctg ccggaacccg gacaacgaca tccgcccgtg gtgcttcgtg      780

ctgaaccgcg accggctgag ctgggagtac tgcgacctgg cacagtgcca gaccccaacc      840

caggcggcgc ctccgacccc ggtgtcccct aggcttcatg tcccactcat gcccgcgcag      900

ccggcaccgc cgaagcctca gcccacgacc cggaccccgc ctcagtccca gaccccggga      960

gccttgccgg cgaagcggga gcagccgcct tccctgacca ggaacggccc actgagctgc     1020

gggcagcggc tccgcaagag tctgtcttcg atgacccgc                            1059


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tggaccaacg gacggatg                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
tgccacttcc ccttccag                                                     18


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
actgtctctg tccacaacac c                                                 21


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
accaacccgt gcctccat                                                     18


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
gtggtgcttc gtgctgaac                                                    19


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
aggatctgac ggtggtgctc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
acaccgatgt ggcctactac                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
ccaggtggtc tcctctgact                                                   20


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
cccaaggtgg aatcgaaagt g                                                 21


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
gtagcacacc agggctgag                                                    19


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
cggagaagct gaggctcaaa g                                                 21


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
gcagaaggct ccggtgtag                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
gttggggtct ggcactgtg                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
gtagctgacg ggcgagaag                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
actgcggaat caccaagga                                                    19


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gcttgacaaa gtggtcgttg a                                                 21


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
catgagggct ctgctgctcc tgg                                               23


<210>  67
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
accaccggca gctgtaccac aaat                                              24


<210>  68
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
tcactggaaa ccactgccag aaagaga                                           27


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
ctgcctagag gtggagggcc acc                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
cgaccggctg agctgggagt act                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
ccaggaacgc cgtaaccaca gct                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
ctggatccgg gagcacaccg ttt                                               23


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
tcaacagcga cacccactcc tc                                                22


<210>  74
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Ala Gln Pro Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr 
1               5                   10                  15      


Pro Pro Gln Ser Gln Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln 
            20                  25                  30          


Pro Pro Ser Leu Thr Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu 
        35                  40                  45              


Arg Lys Ser Leu Ser Ser Met Thr Arg Val Val Gly Gly Leu Val Ala 
    50                  55                  60                  


Leu Arg Gly Ala His Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser 
65                  70                  75                  80  


Phe Cys Ala Gly Ser Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala 
                85                  90                  95      


His Cys Leu Gln Asp Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu 
            100                 105                 110         


Gly Gln Glu Arg Arg Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala 
        115                 120                 125             


Val Arg Ser Tyr Arg Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln 
    130                 135                 140                 


His Asp Leu Ala Leu Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys 
145                 150                 155                 160 


Ala Leu Leu Ser Pro Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala 
                165                 170                 175     


Ala Arg Pro Ser Glu Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His 
            180                 185                 190         


Gln Phe Glu Gly Ala Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln 
        195                 200                 205             


Val Pro Phe Leu Ser Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly 
    210                 215                 220                 


Ser Ser Ile Leu Pro Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly 
225                 230                 235                 240 


Thr Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp 
                245                 250                 255     


Gln Ala Ala Glu Arg Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly 
            260                 265                 270         


Ser Gly Cys Gly Asp Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala 
        275                 280                 285             


Tyr Tyr Leu Ala Trp Ile Arg Glu His Thr Val Ser 
    290                 295                 300 


<210>  75
<211>  903
<212>  DNA
<213>  Homo sapiens

<400>  75
atgcccgcgc agccggcacc gccgaagcct cagcccacga cccggacccc gcctcagtcc       60

cagaccccgg gagccttgcc ggcgaagcgg gagcagccgc cttccctgac caggaacggc      120

ccactgagct gcgggcagcg gctccgcaag agtctgtctt cgatgacccg cgtcgttggc      180

gggctggtgg cgctacgcgg ggcgcacccc tacatcgccg cgctgtactg gggccacagt      240

ttctgcgccg gcagcctcat cgccccctgc tgggtgctga cggccgctca ctgcctgcag      300

gaccggcccg cacccgagga tctgacggtg gtgctcggcc aggaacgccg taaccacagc      360

tgtgagccgt gccagacgtt ggccgtgcgc tcctaccgct tgcacgaggc cttctcgccc      420

gtcagctacc agcacgacct ggctctgttg cgccttcagg aggatgcgga cggcagctgc      480

gcgctcctgt cgccttacgt tcagccggtg tgcctgccaa gcggcgccgc gcgaccctcc      540

gagaccacgc tctgccaggt ggccggctgg ggccaccagt tcgagggggc ggaggaatat      600

gccagcttcc tgcaggaggc gcaggtaccg ttcctctccc tggagcgctg ctcagccccg      660

gacgtgcacg gatcctccat cctccccggc atgctctgcg cagggttcct cgagggcggc      720

accgatgcgt gccagggtga ttccggaggc ccgctggtgt gtgaggacca agctgcagag      780

cgccggctca ccctgcaagg catcatcagc tggggatcgg gctgtggtga ccgcaacaag      840

ccaggcgtct acaccgatgt ggcctactac ctggcctgga tccgggagca caccgtttcc      900

tga                                                                    903


<210>  76
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His Pro 
1               5                   10                  15      


Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser Leu 
            20                  25                  30          


Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp Arg 
        35                  40                  45              


Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg Asn 
    50                  55                  60                  


His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu 
65                  70                  75                  80  


His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu Leu 
                85                  90                  95      


Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro Tyr 
            100                 105                 110         


Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu Thr 
        115                 120                 125             


Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu 
    130                 135                 140                 


Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser Leu 
145                 150                 155                 160 


Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro Gly 
                165                 170                 175     


Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly 
            180                 185                 190         


Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg Arg 
        195                 200                 205             


Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg 
    210                 215                 220                 


Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp Ile 
225                 230                 235                 240 


Arg Glu His Thr Val Ser 
                245     


<210>  77
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  77
atgacccgcg tcgttggcgg gctggtggcg ctacgcgggg cgcaccccta catcgccgcg       60

ctgtactggg gccacagttt ctgcgccggc agcctcatcg ccccctgctg ggtgctgacg      120

gccgctcact gcctgcagga ccggcccgca cccgaggatc tgacggtggt gctcggccag      180

gaacgccgta accacagctg tgagccgtgc cagacgttgg ccgtgcgctc ctaccgcttg      240

cacgaggcct tctcgcccgt cagctaccag cacgacctgg ctctgttgcg ccttcaggag      300

gatgcggacg gcagctgcgc gctcctgtcg ccttacgttc agccggtgtg cctgccaagc      360

ggcgccgcgc gaccctccga gaccacgctc tgccaggtgg ccggctgggg ccaccagttc      420

gagggggcgg aggaatatgc cagcttcctg caggaggcgc aggtaccgtt cctctccctg      480

gagcgctgct cagccccgga cgtgcacgga tcctccatcc tccccggcat gctctgcgca      540

gggttcctcg agggcggcac cgatgcgtgc cagggtgatt ccggaggccc gctggtgtgt      600

gaggaccaag ctgcagagcg ccggctcacc ctgcaaggca tcatcagctg gggatcgggc      660

tgtggtgacc gcaacaagcc aggcgtctac accgatgtgg cctactacct ggcctggatc      720

cgggagcaca ccgtttcctg a                                                741


<210>  78
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly 
1               5                   10                  15      


Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg Arg 
            20                  25                  30          


Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg 
        35                  40                  45              


Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp Ile 
    50                  55                  60                  


Arg Glu His Thr Val Ser 
65                  70  


<210>  79
<211>  213
<212>  DNA
<213>  Homo sapiens

<400>  79
atgctctgcg cagggttcct cgagggcggc accgatgcgt gccagggtga ttccggaggc       60

ccgctggtgt gtgaggacca agctgcagag cgccggctca ccctgcaagg catcatcagc      120

tggggatcgg gctgtggtga ccgcaacaag ccaggcgtct acaccgatgt ggcctactac      180

ctggcctgga tccgggagca caccgtttcc tga                                   213


<210>  80
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa guggcaccga       60

gucggugcuu uu                                                           72


<210>  81
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  82
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uuu                                               83


<210>  83
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  84
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


