                         SEQUENCE LISTING

<110>  Boehringer Ingelheim Vetmedica (China) Co. Ltd.
 
<120>  Recombinant Classical Swine Fever Virus

<130>  P20193023

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  12296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-wt

<400>  1
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca aaacaaaatt ccgatttggc       60

ctagggcacc cctccagcga cggccgaact gggctagcca tgcccacagt aggactagca      120

aacggaggga ctagccgtag tggcgagctc cctgggtggt ctaagtcctg agtacaggac      180

agtcgtcagt agttcgacgt gagcaggagc ccacctcgag atgctatgtg gacgagggca      240

tgcccaagac acaccttaac cctggcgggg gtcgccaggg tgaaatcaca ccatgtgatg      300

ggggtacgac ctgatagggc gctgcagagg cccactaaca ggctagtata aaaatctctg      360

ctgtacatgg cacatggagt tgaatcattt tgaactattg tataaaacaa acaaacaaaa      420

accaatggga gtggaggaac cggtgtatga catcgcaggg agaccattat ttggggaccc      480

aagtgaggta cacccacaat caacactgaa gctaccacac gacaggggaa gaggtaatat      540

cagaactaca ctgaaggacc tacctaggaa aggcgactgc aggagtggaa accacctagg      600

accagttagt gggatatacg taaagcctgg ccctgtcttc tatcaggact acatgggccc      660

tgtctaccat agagccccat tagagttttt tggtgaggcc caattttgtg aggtgaccaa      720

gaggataggt agggtgacgg gtagtgacgg aaagctctac cacatatatg tgtgcatcga      780

cggttgcata ctgttgaagt tagccaaaag gggcgcgccc agatccctaa agtggactag      840

gaacttcacc gactgtccac tgtgggtcac tagttgttct gatgatggca caggtgacag      900

caaggataaa aagccagaca ggatgaacaa gggtaaatta aagatagccc caaaagagca      960

tgagaaggac agtaagacca agccacctga tgctacaatt gtggtagagg gagtaaaata     1020

ccaagtaaaa aagaaaggca aagtcaaagg gaagaacact caagatggcc tgtaccataa     1080

taagaacaaa ccaccagagt ccaggaagaa actagaaaaa gccctattgg cctgggcagt     1140

gatagcaata gtgctgtacc agcctgtagc agccgagaat ataacccaat ggaacctgag     1200

tgacaacggc acaagcggca tccagcaagc tatgtatctc agaggggtca ataggagctt     1260

gcatgggatc tggcctgaaa aaatatgcaa gggggtccct actcatctgg ccactgacac     1320

ggaactgaca gagatacgcg ggatgatgga cgccagtgag aggacgaact acacgtgttg     1380

taggttgcag agacacgaat ggaacaaaca tggctggtgc aactggtaca acatagaccc     1440

ctggattcag ttaatgaaca ggacccaagc aaatttgaca gaaggccctc cagataaaga     1500

gtgtgccgtg acttgcaggt atgacaaaaa taccgatgtt aacgtggtca cccaggccag     1560

gaatagacct actactctga ctggctgcaa gaaagggaaa aatttttcat ttgcaggtac     1620

ggtcatagag ggcccatgca atttcaacgt atccgtggag gacatcttat atggcgacca     1680

tgagtgtggc agcctgttcc aggacacggc tctgtaccta ttagatggaa tgaccaacac     1740

tatagagaaa gccaggcagg gtgcggcaag agtcacatct tggctcggga gacaactcag     1800

aaccacaggg aagaagttgg agagaggaag caaaacctgg ttcggtgcct atgccctgtc     1860

accttactgc aatgtaacaa ggaaaatagg gtacatatgg tacacgaaca attgcactcc     1920

ggcatgcctc ccaaaaaaca caaaaataat aggcccagga aagtttgaca ccaatgcaga     1980

agacgggaag attcttcatg aaatgggggg ccacctatca gaattcttgt tgctttctct     2040

ggtagtcctg tctgacttcg ccccagaaac ggccagtaca ttatacctaa tcttacacta     2100

tgcaatccct cagtcccgtg acgaacccga ggtttgcgat acaaaccagc tcaacctaac     2160

agtgggactt aggacagaag atgtggtacc atcatcagtc tggaatattg gcaaatatgt     2220

gtgtgttaga ccagattggt ggccgtatga aactaaggtg gctctactgt ttgaagaggc     2280

gggacaggtc ataaagttag ctctacgggc actgagggat ttaactagag tctggaacag     2340

tgcatcaact actgcgttcc tcatctgctt gataaaaata ttaagaggac aggttgtgca     2400

aggtataata tggctgctgc tggtgactgg ggcacaaggg cggttgtcct gcaaggaaga     2460

ctacaggtat gcgatatcat caaccaatga gatagggccg ctaggggctg aaggtctcac     2520

caccacctgg aaagaatata accatggttt gcagctggat gacgggactg tcagggccat     2580

ttgcactgca gggtccttta aagttatagc acttaatgtg gtcagtagga ggtacctggc     2640

atcattacac aagagggctt tacccacttc agtaacattt gaactcctat ttgatgggac     2700

tagtccagca attgaggaga tgggagatga ctttggattt gggctgtgcc cttttgacac     2760

aacccccgtg gtcaaaggga agtacaatac cactttatta aacggtagtg ctttctatct     2820

agtctgccca ataggatgga cgggtgtcat agagtgcacg gcagtaagcc ctacaacctt     2880

gagaacagaa gtggtgaaga ccttcaagag agagaagcct ttcccacaca gagtgggttg     2940

cgtgaccact gttgtagaaa aagaagacct gttctactgc aagtgggggg gtaattggac     3000

atgtgtaaaa ggcaacccgg tgacctacat gggggggcaa gtaaaacaat gcagatggtg     3060

cggttttgac ttcaaggagc ccgatgggct cccacactac cccataggca agtgcatcct     3120

agcaaatgag acgggttaca gggtagtgga ttccacagac tgcaatagag atggcgtcgt     3180

tatcagcact gaaggtgaac acgagtgctt gattggcaac accaccgtca aggtgcacgc     3240

gttggatgga agactgggcc ctatgccgtg cagacccaaa gaaatcgtct ctagcgcagg     3300

acctgtaagg aaaacttcct gcaccttcaa ctacacaaag acactaagaa acaagtacta     3360

tgaacccagg gacagctatt tccagcaata tatgcttaag ggcgagtacc aatactggtt     3420

tgatctggac gtgaccgacc accacacaga ctactttgcc gaatttgttg tcttggtggt     3480

agtggcacta ttagggggga ggtacgtcct atggctaata gtgacctatg taattttaac     3540

agagcaactc gctgccggtt tacagctggg ccaaggcgag gtagtactga tagggaactt     3600

aattacccac acggacaatg aggtagtggt atacttctta ctgctctacc taataataag     3660

agacgagcct ataaagaaat ggatactact gctgtttcat gccatgacca acaacccagt     3720

taagaccatg acagtagcat tgctgatgat cagtggggtc gccaagggtg ggaaaacaga     3780

tggtggttgg cagaggcagc cggagaccaa ttttgacatt caactcgcac tggcagttat     3840

agtagtcgtt gtgatgttac tggcaaagag agacccgact acttttcccc tggtgatcac     3900

agtggcaacc ttaagaacag ctaagataac caatggtttc agcacagatc tagctatagc     3960

cacagtgtcg gcagctttgc taacctggac ttatatcagt gactactaca aatataagac     4020

ttggctacag tacctcatca gcacggtgac tgggatcttc ctaataaggg tactgaaggg     4080

aataggcgag ctagacatgc acgccccaac tttgccatct cacagacccc ttttctacat     4140

cctcgtgtac ctcatctcca ctgctgtggt gactagatgg aacctggacg tagccggact     4200

gctgctacag tgtgtcccaa cacttctaat ggtgttcacg atgtgggctg acattctcac     4260

cctaatcctc gtgttaccca cttatgaact ggcaaagttg tattacctta aggaagtgaa     4320

gatcggaacc gaaagaggat ggctgtggaa aactaactat aagagggtaa atgacatcta     4380

tgaagtcgac caagctggcg agggggtcta cctcttccct tcgaaacaaa agactagtgc     4440

tataacaagc accatgttgc cattgatcaa agccatactc attagctgca tcagtaacaa     4500

gtggcaactc atatatttac tgtacctgat attcgaagtg tcctactacc ttcacaagaa     4560

agtcatagat gaaatagctg gtgggaccaa cttcgtttca aggctagtgg cagccttaat     4620

tgaagttaat tgggccttcg acaatgaaga agttaaaggc ctaaagaagt tctttttgct     4680

gtccagtaga gttaaagaat tggtcatcaa acacaaagtg aggaatgaag tagtggcccg     4740

ctggttcgga gatgaagaga tctatgggat gcccaagttg atcggcttag tcaaggcagc     4800

aactctaagt aaaaataaac actgtatctt gtgcaccgtc tgcgaggaca gagattggag     4860

aggagaaacc tgcccaaaat gtgggcgttt cggaccacca gtgatctgtg gtatgaccct     4920

agccgacttc gaggagaagc attataagag gatattcatc agggaggacc aatcagatgg     4980

accgctcagg gaggagcgtg cagggtactt acagtacaga gctaggggtc aactgtttct     5040

gaggaatctc ccagtgttgg cgacaaaagt caagatgctc ctggttggta acctcgggac     5100

ggaggttggg gatttggagc accttggctg ggtgcttaga gggcctgctg tctgcaagaa     5160

ggttactgaa catgaaaagt gtgctacgtc tataatggat aagttgactg ctttcttcgg     5220

cgttatgcca agaggtacca cccccagagc ccccgtgaga tttcccacct ccctcctaaa     5280

gataagaaga gggctagaga cgggttgggc ttacacacat caaggtggca ttagctcagt     5340

tgaccatgtg acttgtggga aagacttgct ggtgtgtgac actatgggcc ggacaagggt     5400

cgtttgccaa tcaaataata agatgactga cgaatccgaa tacggggtca aaaccgactc     5460

agggtgccca gaaggggcca gatgttatgt gttcaaccct gaggcagtta acatatcagg     5520

cactaaaggg gccatggtcc acttacaaaa aactggtggg gagttcacct gcgtaacagc     5580

atcaggaacc ccggccttct ttgatctcaa gaacctcaag ggctggtcag ggctaccgat     5640

attcgaagca tcgagtggaa gggtagtcgg aagggtcaag gtcgggaaga acgatgactc     5700

taaaccaacc aaactcatga gtgggataca aacggtctct aaaagtgcca ctgacctgac     5760

ggagatggta aagaagataa caactatgaa caggggagag ttcagacaga taaccttggc     5820

cacaggtgct gggaaaacta cagagctccc caggtcagtc atagaagaga tagggagaca     5880

caaaagggtg ttggtattga tccccttgag ggccgcagca gaatcagtat accaatatat     5940

gaggcagaaa cacccaagta tagcattcaa cctgaggata ggggagatga aggaaggtca     6000

catggccacg gggataacct atgcctccta cggttacttt tgccagatgc cacaacctaa     6060

gctgagggcc gcaatggtag agtactccta catctttcta gatgagtacc attgtgccac     6120

cccagaacaa ctggctatca tggggaagat ccacagattc tcagagaacc tgcgggtggt     6180

agctatgaca gcgacaccag cagggacagt aacaactact gggcagaaac accctataga     6240

ggagttcata gccccggaag taatgaaagg agaagactta ggttcagagt acttagacat     6300

tgccggacta aagataccag tagaggagat gaagaacaac atgctagttt ttgtaccaac     6360

taggaatatg gcggtagagg cggcaaagaa actgaaagct aaaggataca actcaggcta     6420

ttactacagt ggtgaggatc catctaacct gagggtagtc acatcgcagt ccccatacgt     6480

ggttgtagcg accaacgcga tagaatcagg cgtcactctc ccggaccttg acgtggtcgt     6540

tgacacggga ctcaagtgtg agaaaagaat ccgattgtca cccaagatgc ctttcatagt     6600

gactggccta aaaagaatgg ctgttaccat tggggaacaa gcccagagaa gagggagggt     6660

tggaagagta aagcccggga gatactacag gagccaagaa acccctgtcg gctctaagga     6720

ctaccactac gatttattgc aagcccagag gtacggtata gaagatggga taaatatcac     6780

caaatccttc agagaaatga actatgattg gagcctctat gaggaagata gcctgatgat     6840

aacacaattg gaaatcctca acaatctact gatatcagag gagctgccgg tggcagtaaa     6900

aaatataatg gctaggactg accacccaga accaattcaa ctagcatata atagctacga     6960

gacacaagtg cctgtgttgt tcccaaaaat aagaaatgga gaggtgactg acacttacga     7020

tacttacacc ttcatcaatg caagaaaatt gggagatgat gtacctccct acgtgtatgc     7080

cacagaagat gaggacttgg cagtggaact gttgggccta gattggccgg accctgggaa     7140

ccaaggcact gtggaggccg gcagagcact aaaacaggtg gtcggtctat caacagccga     7200

gaatgccctg ttagtagcct tgtttggcta cgtagggtac caggccctct caaagaggca     7260

tatacctgtg gtcacagaca tatactcagt tgaagatcac aggctagagg acaccacaca     7320

cctacagtac gctccgaatg ccatcaagac ggaggggaag gagactgaat tgaaggagtt     7380

ggctcagggg gatgtgcaga gatgcgtgga agcgatgacc aattacgcga gagggggcat     7440

ccaatttatg aagtcacagg cactgcaggt gagagaaacc cccacttata aagagacaat     7500

gaatactgta gcagactatg tgaaaaagtt tatcgaggca ctgtctgata gcaaggaaga     7560

catcttgaaa tatgggctgt ggggcgtaca tacggccttg tacaagagca ttggtgccag     7620

gcttggtcac gaaaccgcgt tcgcaaccct agccgtgaaa tggctggcat ttggggggga     7680

atcaatagca gatcatataa aacaagcggc tacagacttg gtcgtctact atatcatcaa     7740

cagacctcag ttcccaggag acacagagac acaacaggag gggagaaatt ttgtggccag     7800

cctactggtc tcagccctag caacttacac atataaaagc tggaactata ataacctgtc     7860

caagatagta gaaccggctt tggccaccct gccctatgcc gctaaagccc ttaaattatt     7920

tgcccctacc aggctagaga gcgtcgtcat attgagcacc gcaatctaca aaacatacct     7980

atcaatcagg cgaggcaaaa gcgatggatt gctaggtaca ggggttagtg cggctatgga     8040

gattatgtca caaaatccgg tatcagtggg catagcagtt atgctggggg ttggggctgt     8100

agcagcacac aacgcaattg aagccagtga gcagaagaga acactactta tgaaagtttt     8160

tgtaaagaac ttcttggacc aagcagccac agatgaacta gtcaaagaga gccctgagaa     8220

aataataatg gccttgtttg aagcagtgca aacagtaggc aatcctctta ggctagtgta     8280

ccacctttac ggggtttttt ataaagggtg ggaagcaaaa gagttggccc aaaggacagc     8340

cggcaggaat cttttcacct tgataatgtt tgaggccgtg gaactattgg gagtagatag     8400

cgaaggaaaa atccgccaac tatcgagtaa ttacatatta gagctcctgt ataagttccg     8460

tgacagtatc aaatctagtg tgagggagat agcaatcagc tgggcccctg ccccctttag     8520

ttgcgattgg acaccaacag atgacagaat agggcttccc cataacaatt acctccaaat     8580

ggagacaaga tgcccttgtg gctacaggat gaaagcagta aaaacctgtg ctggggagtt     8640

gagacttctg gaagagggag gttcattcct ctgcaggaat aaattcggta gagggtcacg     8700

gaactatagg gtgacaaaat actatgatga caatttatca gaaataaaac cagtgataag     8760

aatggaagga catgtggaac tatattataa gggggccact atcaaactgg actttaacaa     8820

cagtaaaaca gtactggcaa ccgacaaatg ggaggttgac cattccaccc tggtcagggc     8880

gctcaagagg cacacagggg ctgggtacca aggagcgtat atgggtgaga aacctaacca     8940

caaacatctg atagagagag actgtgcaac gatcacaaaa gacaaggttt acttcatcaa     9000

gatgaagagg gggtgtgcgt tcacttatga cttgtccctc cacaacctca cccggttaat     9060

cgaattggta cacaaaaacg acctggaaga tagagaaatc cctgctgtta cggttacaac     9120

ctggctggcc tacacatttg tgaatgaaga catagggacc ataaaaccag tttttgggga     9180

aaaagtaaca ccggaaaaac aggaggaggt agccttgcag cctgctgtgg tggtggacac     9240

aacagatgtg gccgtgaccg tggtggggga aacctctact atgactacag gggagacccc     9300

aacggcattc accagcttag gttcagactc taaagttcaa caagttctga agttaggggt     9360

ggatgagggt caataccccg ggcccagtca gcagagagca agcttgctcg acgctataca     9420

aggcgtggat gaaaggccct cggtattgat attgggatct gataaggcca cctccaatag     9480

ggtgaagacc gcaaagaatg tcaagatatt caggagcaga gaccccctgg aactgagaga     9540

aatgatgaga agagggaaga tcctggtcat agccctatgt aaggtcgaca ctgctctact     9600

gaaatttgtt gattacaaag gcaccttcct gaccagagaa accctagagg cattaagttt     9660

gggtaagcct aagaaaaaaa acataaccaa gacagaggca caatggttgt tgtgcctcga     9720

aaaccaaata gaagagctgc ctgactggtt cgcagctgag gagcccgtat ttctggaagc     9780

caacatcaaa cgtgacaagt atcacctagt gggggatata gctactatca aagaaaaagc     9840

taaacaactg ggggcaacag actccacaaa gatatcaaaa gaggttggag ctaaagtata     9900

ttctatgaag ctgagtaact gggtgataca agaagagaat aaacagggca gcttagcccc     9960

tttgtttgaa gagctcctgc aacagtgccc acctgggggc cagaataaaa ccacacatat    10020

ggtctcagcc taccaactgg ctcaagggaa ctggatgcca gttggttgtc acgtgttcat    10080

ggggaccata cccgccagaa gaaccaagac ccatccctat gaggcatacg tcaagctgag    10140

ggagttggta gatgaatata agatgaagac gctatgtggc ggttcaggcc taagtaagca    10200

caacgaatgg gtaattcgta agatcaagca tcaagggaac ctgaggacca aacacatgtt    10260

gaaccccggg aaggttgcag agcaactgct tagagaagga cacagacaca atgtatataa    10320

taagactata ggctcagtga tgacagcaac tggtatcagg ctggaaaagt tacccgtggt    10380

cagggcccaa acagacacaa ccaacttcca tcaagcaata agggataaaa tagacaagga    10440

agagaactta cagactccag gcttacacaa gaagttaatg gaagtcttca atgcattaaa    10500

aagacccgat cttgaggcct cttacgacgc tgtggagtgg gaggaattgg agaaaggaat    10560

aaataggaag ggtgctgcag gtttctttga acacaagaat ataggagagg ttctggattc    10620

agaaaaaaac aaggttgaag agatcataga cagtttgaga aaaggtagga gtatcaggta    10680

ctatgaaact gcaatcccaa aaaacgagaa gagggacgtc aatgatgact ggactgccgg    10740

tgactttgta gacgagaaaa agcccagggt gatacaatac cctgaggcta aaaccaggtt    10800

ggccatcact aaagtaatgt acaagtgggt gaagcagaaa ccagtagtca tacccggcta    10860

tgaaggtaag acacctctgt tccaaatctt tgacaaagtg aagaaagaat gggaccaatt    10920

ccaaaatcca gtggctgtga gctttgacac caaagcgtgg gacacccagg tgactacagg    10980

agacctggaa ctaataaggg atatacagaa gttctacttc aagaagaagt ggcacaaatt    11040

cattgacacc ctaaccatgc acatgtcaga agtacccgta attagtgccg acggggaggt    11100

gtacataagg aaggggcaga gaggcagtgg acaacctgat acgagcgcag gcaacagcat    11160

gttgaatgta ttaacaatgg tttatgcctt ctgtgaggcc acgggagtgc cctataagag    11220

ttttgacaga gtggcaaaga tccacgtctg cggggatgat ggtttcttga tcactgaaag    11280

ggctcttggt gaaaaatttt cgagtaaagg agtccagatc ctatatgaag ctggtaagcc    11340

ccaaaaaatt acagaagggg ataagatgaa agtggcctac cagtttgatg acatcgagtt    11400

ctgctcccat acaccagtgc aagtaaggtg gtcagacaat acttccagtt atatgccggg    11460

gaggaacacg actacaatcc tggcaaaaat ggctacaagg ttagattcca gtggtgagag    11520

gggcactata gcatatgaga aggcggtggc gtttagcttc ttattgatgt actcctggaa    11580

cccactgatc agaaggatat gcttactggt gttgtcaact gaactgcaag tgagaccagg    11640

gaagtcaacc acctattact atgaagggga cccaatttct gcttacaagg aggtcatagg    11700

ccataatctc tttgacctta aaagaacaag ctttgagaaa ctagctaagt taaatcttag    11760

tatgtccaca ctcggggtat ggaccagaca caccagcaaa agattactac aagactgtgt    11820

caacgtcggc actaaagagg gcaactggct ggttaatgca gacagactgg tgagtagcaa    11880

gacaggaaat aggtatatac ctggagaggg tcatacccag caagggaaac attatgaaga    11940

actgatattg gcaaggaagc cgatcagcaa ttttgaaggg actgatagat acaatttggg    12000

cccaatagtc aacgtagtgt tgaggaggct gagagtcatg atgatggctc ttataggaag    12060

gggggtgtaa gcatggccgg cccttaaccg ggccctatca gtagaaccct gttgtaaata    12120

acactaactt attatttatt taaatactat tatttattta tttatttatt tattgaatga    12180

gcaaggattg gtacaaacta cctcatgtta ccacactaca ctcattttaa cagcacttta    12240

gctggaggga aaatcctgac gtccatagtt ggactaaggt aatttcctaa cggccc        12296


<210>  2
<211>  12299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GD18-wt


<220>
<221>  misc_feature
<222>  (12256)..(12256)
<223>  n is a, c, g, or t

<400>  2
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca agaccaaaat tccgatttgg       60

cctagggcac ccctccagcg acggccgaac tgggctagcc atgcccacag taggactagc      120

aaacggaggg actagccgta gtggcgagct ccctgggtgg tctaagtcct gagtacagga      180

cagtcgtcag tagttcgacg tgagcaggag cccacctcga gatgctatgt ggacgagggc      240

atgcccaaga cacaccttaa ccctggcggg ggtcgccagg gtgaaatcac accatgtgat      300

gggggtacga cctgataggg tgctgcagag gcccactaac aggctagtat aaaaaatctc      360

tgctgtacat ggcacatgga gttgaatcat tttgaactac tatacaaaac aaataaacaa      420

aaaccaatag gagtggagga accggtgtat gacatcgcag gaagaccatt tttcggggac      480

ccaagtgagg tacacccaca atcaacactg aagctgccac atgacagggg gagaggtaat      540

atcagaacta cactgaagaa cctacctagg aaaggcgact gtaggagtgg aaaccaccta      600

ggaccagtca gtgggatata tgtaaaaccc ggccctgtct tctatcagga ctacatgggc      660

cctgtctatc atagagctcc attggagttt tttgaagagg cccagctgtg tgaggtgact      720

aagagaatag gtagggtgac gggtagtgat gggaagcttt accacatata tgtgtgcatt      780

gacggttgca tactgctgaa gttagccaaa aggggcacgc ctagatccct aaagtggact      840

aggaacttca ccgactgtcc actatgggtc actagttgtt ctgatgatgg cgcaggtggc      900

agcaaggata agaaaccaga caggatgaac aagggtaaat taaaaatagc cccaaaagag      960

catgagaagg acagcaaaac caagccacct gatgccacga tcgtggtaga gggagtaaaa     1020

taccaagtga aaaagaaagg caaagtcaaa gggaagaaca ctcaagatgg cctataccat     1080

aataagaaca aaccaccaga gtccaggaag aaactagaaa aagccctact ggcttgggca     1140

gtgataacaa tcgtactgta ccagcctgta gcggccgaga atataactca gtggaacctg     1200

agtgacaatg gcacaagcgg tatccagcaa gccatgtatc ttagaggggt taataggagt     1260

ctacatggga tctggcctga aaaaatatgc aaaggggtcc ctactcacct ggctactgat     1320

acggagctga cagagatacg agggatgatg gacgccagcg agaggacaaa ctatacgtgt     1380

tgcaggttgc agagacacga atggaataaa catggatggt gtaactggta caacatagac     1440

ccctggattc aattaatgaa caggacccaa gcaaatctga cagaaggccc cccggataag     1500

gagtgcgccg tgacttgcag gtatgacaaa aatgctgacg ttaacgtggt cacccaggcc     1560

aggaatagac caaccactct gaccggctgc aagaaaggaa aaaacttttc atttgcaggt     1620

acgattatag agggcccatg caatttcaac gtctccgtgg aggacatcct atatggggac     1680

catgagtgtg gcagcctgtt ccaggacaca gctctgtacc tattagatgg aatgaccaac     1740

actatagaga aagccaggca gggtgcggca agagttacat cctggcttgg gaggcaactc     1800

agcaccacag ggaagaagtt ggagagagga agcaaaacct ggttcggcgc ctacgccctg     1860

tcaccttact gtaacgtaac aaggaaagtg gggtacatat ggtatacgaa caattgcact     1920

ccggcatgtc tcccaaaaaa cacgaaaata ataggtccag gaaaattcga taccaacgcg     1980

gaagatggga agatacttca tgaaatgggg ggccacctat cagaattttt gttgctttct     2040

ttagtaatcc tgtctgactt cgccccggag acggccagta cgctatacct aatcttacac     2100

tatgcaatcc ctcagtccca tgaagagcct gaaggttgcg atacgaacca gctcaatcta     2160

acagtgggac ttaggacaga agatgtggta ccatcatcag tttggaatat cggcaaatat     2220

gtgtgtgtca gaccagactg gtggccgtat gaaactaagg tggctttgct gtttgaggag     2280

gcaggacagg ttataaaact agctctacgg gcactgagag atttaactag agtctggaac     2340

agtgcatcaa ctactgcgtt cctcatctgc ttgataaaaa tattaagagg acaggttgtg     2400

caaggtataa tatggctgct gctggtaact ggggcacaag ggcggttgac ctgtaaggaa     2460

gactacaggt atgcgatatc atcaaccaat gagatagggc cgcttggagc tgaaggtctc     2520

actaccacct ggaaagaata caaccatggt ttacagctgg atgacgggac tgtcagggcc     2580

acttgcactg cagggtcctt taaagttata gcacttaatg tggttagtag gaggtacctg     2640

gcatcattac acaagagggc tttgcccacc tcagtaacat ttgaactcct atttgatggg     2700

accagcccag taattgagga gatgggagac gactttggat ttgggctgtg cccttttgac     2760

acgatccctg tggtcaaagg gaagtataac accaccttat taaacggcag tgctttctat     2820

ctagtctgcc ctataggatg gacgggtgtt atagagtgca cggcagtaag ccccacaacc     2880

ttgagaacag aagtggtgaa gaccttcaag agagagaagc ctttccctca cagagtggac     2940

tgcgtgacca ctatagtaga aaaagaagac ctgttctatt gcaggctggg gggtaattgg     3000

acatgcgtga aaggtgaccc ggtgacctac acggggggcc aagtaaaaca atgcaggtgg     3060

tgcggtttca acttcaagga gcctgatggg ctcccacact accccatagg caagtgcatc     3120

ctagcaaatg agacgggata cagggtagtg gactccacag actgcaacag agacggcgtc     3180

gtcatcggca ctgaaggaga gcatgagtgc ttgatcggca acaccaccgt caaggtgcac     3240

gcgctggacg gaagactggc ccctatgcct tgcagaccca aagaaatcgt atctagtgcg     3300

ggacctgtaa ggaaaacttc ctgcacattt aactatacaa agactttgag gaacaagtac     3360

tatgagccca gggacagcta cttccagcaa tacatgctta agggcgagta tcaatactgg     3420

tttgatctgg acgtgacaga ccaccacaca gactacttcg ccgagtttgt tgtcttggtg     3480

gtagtggcac tattaggggg aaggtacgtc ctgtggctaa tagtgaccta tatagttcta     3540

acagagcaac tcgctgctgg tttacagcta ggccagggcg aggtggtgct gatagggaac     3600

ttaatcaccc acatggacaa cgaggtagtg gtatacttct tactgcttta cctaataata     3660

agagacgagc ccataaagaa atggatacta ctgctgttcc atgccatgac caacaaccca     3720

gttaagacca tgacagtagc attgctaatg ataagcgggg tagccaaggg tgggaaaata     3780

gatggtggtt ggcagaggca gccggagacc aattttgaca tccaattcgc actggcagtc     3840

ataatagtcg tcgtgatgtt gttggcaaag agagatccga ctacttttcc cctggtgatc     3900

actgtggcaa ccttgagaac ggctaagata accagtggtt tcagcacaga tctagccata     3960

gccacagtgt cggcaacttt gctaacctgg acttatatca gtgactacta caaatacaag     4020

acttggctac agtacctcat cagcacggtg actggaattt ttctgataag ggtactgaag     4080

ggggtcggcg agttggacct acacgccccg actctgccat cccacagacc ccttttctac     4140

atccttgtgt acctcatctc cactgccgtg gtaacgagat ggaacttgga cgtagccgga     4200

atactgctac agtgcgcccc aacacttcta atggtattca cgatgtgggc tgacatcctc     4260

accctaattc tcatactgcc cacctatgag ttgacaaagt tatattacct taaggaagtg     4320

aagataggga ctgaaagagg atggctgtgg aaaactaatt acaagagggt aaatgacatc     4380

tatgaagtcg accaagctgg cgaaggggtt tacctcttcc cttcgaaaca aaagactgga     4440

gctataacga gcaccgtgtt gccgttgatc aaagccatac tcattagctg catcagtaac     4500

aagtggcaat tcatatattt actgtacttg atatttgagg tgtcctacta ccttcacaag     4560

aaaatcatag atgagatagc cggcgggacc aacttcgttt cgagactagt ggcggcttta     4620

attgaagtta attgggctct agacaatgaa gaagtcaaag gcctaaagaa gtttttcttg     4680

ttgtctagta gggtcaaaga gttggttatc aaacacaaag tgaggaatga agtaatggtc     4740

cgctggtttg aagatgaaga gatctacggg atgccaaagc tgatcggcct ggttaaggca     4800

gcaacactga gcaaaaacaa acactgtatt ttgtgcaccg tctgtgagga cagagattgg     4860

cggggagaaa cttgcccgaa atgcgggcgt tttggaccac cagtgatctg tggtatgacc     4920

ctagctgact tcgaggaaaa acactataag aggattttca tcagggagga ccaatcagac     4980

gggccgctca gggaggagca tgcagggtac ttgcagtaca aagctagggg tcaattgttt     5040

ctgaggaatc tcccagtgtt ggcaacaaaa gtcaagatgc ttctggttgg caacctaggg     5100

acagaggttg gggacctgga gcaccttggc tgggtgctca gagggcccgc tgtctgcaag     5160

aaggttactg aacatgaaaa gtgtgctacg tctataatgg ataagttgac tgccttcttt     5220

ggtgtcatgc caaggggtac cacccccaga gctcctgtaa gatttcccac ctcccttcta     5280

aagataagaa gagggctgga gacgggttgg gcttatacac accaaggcgg tatcagctca     5340

gttgaccatg ttacttgcgg gaaagacctg ctagtgtgtg acaccatggg tcggacaagg     5400

gttgtctgcc aatcgaataa caagatgact gacgagtctg aatacggagt caaaaccgac     5460

tcagggtgcc cagagggagc caggtgctac gtgttcaacc ctgaggcagt taatatatca     5520

ggcactaaag gagccatggt ccacttacag aaaactggtg gagaattcac ctgtgtaaca     5580

gcatcaggga ccccagcttt cttcgatctc aagaacctca agggttggtc agggctaccg     5640

atatttgaag catcgagtgg aagggtagtc ggaagggtca aggtcgggaa gaacgaagac     5700

tctaaaccaa ccaaactcat gagtgggata caaacggtct ctaaaagtgc cactgatttg     5760

acggagatgg tgaagaagat aacaaccatg aacagggggg agttcagaca aataaccttg     5820

gccacaggtg ctggaaaaac tacagagcta cccaggtcag tcatagaaga gatagggaga     5880

cacaaaaggg tgctggtatt gatccccctt agggccgcag cagaatcagt ataccaatac     5940

atgaggcaga aacacccgag tatagcattc aacctgagga taggggagat ggaggaagga     6000

tacatggcca cgggaataac ctatgcttct tatggttact tttgccagat gccacaaccc     6060

aagttgagag ccgcaatggt agagtattcc tacatctttc tagacgagta ccattgcgcc     6120

accccggaac aattggctat catggggaag atccacagat tctcagagaa cctgcgggtg     6180

gtcgctatga cagcgacgcc ggcaggcacg gtaacaacta ctgggcagaa acaccctata     6240

gaggagttca tagccccgga agtgatgaaa ggagaagact taggttcaga gtacttagac     6300

atcgccggac taaagatacc agtagaggag atgaagaaca acatgctagt ttttgtacca     6360

actaggaaca tggcagtgga ggcggcaaag aaattgaaag ccaaaggata taactcaggc     6420

tattactaca gtggtgagga cccatccaac ctgagggtag ttacatcgca gtccccatac     6480

gtggtggtag cgaccaacgc aatagaatca ggcgtcactc tcccagacct tgatgtggtc     6540

gttgacacag gactcaagtg tgagaaaaga atccgactgt cacccaagat gcctttcata     6600

gtgactggcc tgaaaagaat ggccgtcact attggggaac aagcccagag aagagggagg     6660

gttggaagag taaagcccgg gagatactac aggagccaag aaactccagt cggctctaag     6720

gactaccact atgacttgct gcaagcccaa aggtacggta tagaagatgg gataaatatc     6780

accaaatcct tcagagagat gaactacgat tggagccttt atgaggaaga tagcctgatg     6840

ataacacaac tggaaatcct caacaatctg ttgatatcag aggagctgcc ggtagcagta     6900

aaaaatataa tggctaggac tgaccaccca gaaccaattc aactagcgta taatagctac     6960

gagacacagg taccagtgtt gttcccaaag ataaggaatg gagaggtgac tgacacttac     7020

gacaactaca ccttcctcaa tgcaagaaaa ttgggagatg atgtaccccc ctatgtgtat     7080

gccacagaag atgaggactt ggcagtggaa ctgttaggcc tagattggcc agaccctgga     7140

aaccaaggca ctgtggaggc tggcagagca ctaaaacagg tggtcggcct atcaacagcc     7200

gagaatgccc tgctagtggc cttgtttggc tacgtagggt accaggccct ctcaaaaagg     7260

catatacctg tagtcacaga catatattca gttgaagatc acaggttgga agatacaaca     7320

cacctacagt atgccccgaa cgccatcaag acggagggga aggagactga attgaaggag     7380

ttggctcaag gggatgtgca gagatgtgtg gaagcagtgg ccaattatgc gagtgagggc     7440

atccaattta ttaagtcaca ggcactgaag gtgagagaga ccccgactta caaagagaca     7500

atgaatacag tggcagacta tgtgaaaaag ttcattgagg cactgtcaga tagcaaggaa     7560

gacatcttga aatatgggct gtggggtgta cacacggcct tgtataagag cattggtgcc     7620

agactaggtc acgaaactgc gttcgcaact ttagtcgtga aatggttggc atttgggggg     7680

gaatcagtaa cagatcacat aaagcaagca gccacagact tggttgttta ctatattatc     7740

aacagacctc aattcccagg ggacacggag acacaacaag aagggaggaa atttgtggcc     7800

agcttactgg tctcagccct agcaacctac acatacaaaa gctggaacta caacaatctg     7860

tccaagatag ttgaacctgc tttggccact ttgccctacg ccgccaaagc ccttaaatta     7920

ttcgccccta cccgactgga gagcgtcgtc atattgagca ccgcaatcta caaaacatat     7980

ctatcaatca ggcgaggcaa aagtgatgga ttgcttggta caggggttag tgcggctatg     8040

gagattatgt cacaaaatcc agtatcagtg ggcatagcag tcatgctggg ggttggggct     8100

gtagcagccc ataatgcaat tgaagccagt gagcagaaga gaacactact aatgaaagtc     8160

tttgtgaaaa acttcttgga ccaagcagcc acggatgaac tagtcaaaga gagccctgag     8220

aaaataataa tggccctgtt tgaagcagtg cagacggtag gcaaccctct cagactggtg     8280

taccacctat atggagtttt ttataaaggg tgggaagcaa aagagttggc ccaaaggaca     8340

gccggcagga acctcttcac cttaataatg ttcgaggctg tggaactact gggagtagat     8400

agtgaaggga aaatccgcca gctctcaagt aactacatat tagagctcct gtacaagttc     8460

cgtgacgaca tcaaatctag tgtgagggag atagcaatca gttgggcccc tgcccccttc     8520

agctgcgact ggacaccaac agatgacaga ataggacttc cccatgacaa ttatctccag     8580

atggagacaa gatgtccttg tggttacagg atgaaagcag taaaaacctg tgccggggag     8640

ttgagactcc tggaagaggg gggttcattc ctctgcagga ataaattcgg cagagggtca     8700

cggaattata gggtgacaaa atattatgat gacaacttat cagaaataaa accagtgata     8760

agaatggaag gacacgtgga actgtatcat aaaggggcca ctttcaaact ggactttgac     8820

aacagtaaaa cagtactggc aacagataga tgggaagtcg accattccac cctgatcagg     8880

gtgctcaaga ggcacacagg ggctggattt caaggggcgt atctgggtga gaaacccaat     8940

cacaagcacc tgatagagag agactgtgca acgatcacaa aagacaaggt ctgcttcatc     9000

aaaatgaaga gggggtgcgc gttcacctat gacttatcac tccacaacct tacccggcta     9060

atcgaattgg tacataagaa caacctggat gacagagaaa tccctgccgt tacggtcaca     9120

acctggctgg cctacacatt cgtgaatgaa gacataggga ccataaaacc agtcttcggg     9180

gaaaaagtaa caccggagaa gcaggaggag gtagccttgc agcctgcagt ggtggtggac     9240

acaacagatg tggccgtgac cgtggtgggg gaaacctcca ctatgaccac aggggagacc     9300

cccacaatat ttaccagctt aggttcggac tctaagtttc aacaagtcct gaaactgggg     9360

gtggatgagg gtcaatatcc cgggcccagg cagcagagag caagtttgct cgaagctgta     9420

caaggtgtag atgagaggcc ctcggtacta atattggggt ctgataaggc cacctccaat     9480

agggtgaaga ccgcaaagaa tgtgaagata ttcaggagca gagaccccct ggaactgaga     9540

gagatgatga gaagagggaa gatcctaatc atagccctgt gtaaggtgga caccgctctg     9600

ctgaaatttg ttgattacaa aggtaccttc ctgaccagag agaccctaga ggcattaagt     9660

ctgggcaaac ctaagaaaag agacataact aagacagagg cacgatggtt gttgtgcctc     9720

gaaggtcaat tagaagagct gcctgactgg tttgcagcca aggagcccat attcttagaa     9780

gccaacatca aacgtgacaa gtatcatctg gtgggagaca tagctacaat caaagaaaaa     9840

gccaagcaac tgggggcaac agactccaca aagatatcaa aagaggttgg cgcgaaagtg     9900

tattctatga agttgagtaa ctgggtgata caggaagaga ataaacaggg cagcttaacc     9960

cccttgtttg aagagctcct gcaacagtgc ccgcccgggg gccagaataa aaccacacat    10020

atggcctcag cctaccaatt ggctcagggg aactggatgc cagttggttg ccacgtgttc    10080

atggggacca tacccgctag aagaaccaag actcatccct acgaggcata tgtcaagttg    10140

agggagttgg tggaagaaca taagatgaag acatcatgtg gcggttcagg cctatgtaag    10200

cacaacgaat gggtaattcg taagatcaag catcaaggga acctgaggac cagacacatg    10260

ctgaaccccg gaaagattgc tgagcaactg gatagagaag ggcacagaca caatgtgtac    10320

aacaagacca taggctcagt aatgacagcg actggcatca ggctggaaaa gttacccgtg    10380

gttagagccc agacagatac aactaatttc caccaagcaa taagggataa aatagacaag    10440

gaagagaacc tacagacccc aggcttacac aagaagttaa tggaggtatt caatgcatta    10500

aaaagacctg agcttgaggc ctcttacgac gccgtggagt gggaggaatt ggagagagga    10560

ataaatagga agggtgctgc agggttcttc gaacgcaaga atataggaga ggtcctagat    10620

tcagaaaaat ataaggttga agagatcata gacagtttga agaaaggtag gagtattaaa    10680

tattatgaaa ctgcaatccc aaagaacgaa aagagggatg tcaatgatga ctggactgcc    10740

ggagactttg tggatgagaa aaaacccagg gtgatacaat atcctgaggc caaaaccagg    10800

ttagccatca ctaaagtgat gtataagtgg gtgaaacaga aaccagtagt catacccggc    10860

tatgaaggta agacacctct gttccaaatt tttgacaaag tgaaaaaaga atggaaccaa    10920

ttccaaaatc cagtggcagt gagctttgac actaaagcat gggataccca ggtgactaca    10980

agagacctgg aactaataag ggatatacag aagttctatt tcaagaagaa gtggcacaaa    11040

ttcatcgaca ccctaaccat gcacatgtca gaagtacccg tgattagtgc cgacggggag    11100

gtgtatataa ggaaagggca gagaggcagt gggcaacctg atacgagcgc aggcaacagt    11160

atgctgaatg tgttaacaat ggtttatgcc ttctgtgagg ccacgggggt accctataaa    11220

agtttcgaca gagtggcaaa gatccacgtc tgtggggatg atggcttctt gattactgaa    11280

agggctcttg gtgaaaaatt tgcaagtaga ggagtccaga tcctatatga agccgggaag    11340

ccccaaaaaa tcactgaagg ggacaatatg aaagtggcct atcagtttga cgacatcgag    11400

ttctgctccc atacaccagt gcaggtaagg tggtcagaca acacctccag ttacatgccg    11460

gggaggaaca caaccacaat actggcaaaa atggctacaa ggttggattc cagtggtgag    11520

agaggcacta tagcatatga gaaggcagtg gcattcagtt tcttgttgat gtactcctgg    11580

aacccactga ttagaaggat atgcttattg gtgttatcaa ctgaaatgca agtgagacca    11640

gggaagtcaa ccacctatta ctatgaagga gacccaatat ctgcttacaa ggaggtcatc    11700

ggccataatc tctttgacct taaaagaaca agtttcgaga agctagctaa gctaaatctt    11760

agtatgtcca cactcggggt atggaccagg cataccagca aaagattact acaagactgt    11820

gtcaatgtcg gcaccaaaga gggcaactgg ctggttaacg cagacagact ggtgagtagt    11880

aagacaggga ataggtatat acctggagag ggtcataccc aacaaggaaa acattatgaa    11940

gagctggtat tggcaagaaa accgaccagt aattttgaag ggactgatag atataatttg    12000

ggcccaatag tcaacgtagt gttgaggagg ctgagagtca tgatgatggc tcttatagga    12060

aggggggtgt gagagcggcc ggctcttgac cgggccctat cagtataacc ctgttgtaaa    12120

taacactaac ttattattta tctagacact actatttatt tatttattta tttattgaat    12180

gagcaaggaa tggtacgaac tacctcatgt taccacacta cactcatttt aacagcactt    12240

tagctgagga aaaaantcct gacgtccata gttggactaa ggtaatttcc taacggccc     12299


<210>  3
<211>  12293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-sdErnsH-KARD

<400>  3
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca aaacaaaatt ccgatttggc       60

ctagggcacc cctccagcga cggccgaact gggctagcca tgcccacagt aggactagca      120

aacggaggga ctagccgtag tggcgagctc cctgggtggt ctaagtcctg agtacaggac      180

agtcgtcagt agttcgacgt gagcaggagc ccacctcgag atgctatgtg gacgagggca      240

tgcccaagac acaccttaac cctggcgggg gtcgccaggg tgaaatcaca ccatgtgatg      300

ggggtacgac ctgatagggc gctgcagagg cccactaaca ggctagtata aaaatctctg      360

ctgtacatgg cacatggagt tgaatcattt tgaactattg tataaaacaa acaaacaaaa      420

accaatggga gtggaggaac cggtgtatga catcgcaggg agaccattat ttggggaccc      480

aagtgaggta cacccacaat caacactgaa gctaccacac gacaggggaa gaggtaatat      540

cagaactaca ctgaaggacc tacctaggaa aggcgactgc aggagtggaa accacctagg      600

accagttagt gggatatacg taaagcctgg ccctgtcttc tatcaggact acatgggccc      660

tgtctaccat agagccccat tagagttttt tggtgaggcc caattttgtg aggtgaccaa      720

gaggataggt agggtgacgg gtagtgacgg aaagctctac cacatatatg tgtgcatcga      780

cggttgcata ctgttgaagt tagccaaaag gggcgcgccc agatccctaa agtggactag      840

gaacttcacc gactgtccac tgtgggtcac tagttgttct gatgatggca caggtgacag      900

caaggataaa aagccagaca ggatgaacaa gggtaaatta aagatagccc caaaagagca      960

tgagaaggac agtaagacca agccacctga tgctacaatt gtggtagagg gagtaaaata     1020

ccaagtaaaa aagaaaggca aagtcaaagg gaagaacact caagatggcc tgtaccataa     1080

taagaacaaa ccaccagagt ccaggaagaa actagaaaaa gccctattgg cctgggcagt     1140

gatagcaata gtgctgtacc agcctgtagc agccgagaat ataacccaat ggaacctgag     1200

tgacaacggc acaagcggca tccagcaagc tatgtatctc agaggggtca ataggagctt     1260

gcatgggatc tggcctgaaa aaatatgcaa gggggtccct actcatctgg ccactgacac     1320

ggaactgaca gagatacgcg ggatgatgga cgccagtgag aggacgaact acacgtgttg     1380

taggttgcag agacacgaat ggaacaaagg ctggtgcaac tggtacaaca tagacccctg     1440

gattcagtta atgaacagga cccaagcaaa tttgacagaa ggccctccag ataaagagtg     1500

tgccgtgact tgcaggtatg acaaaaatac cgatgttaac gtggtcaccc aggccaggaa     1560

tagacctact actctgactg gctgcaagaa agggaaaaat ttttcatttg caggtacggt     1620

catagagggc ccatgcaatt tcaacgtatc cgtggaggac atcttatatg gcgaccatga     1680

gtgtggcagc ctgttccagg acacggctct gtacctatta gatggaatga ccaacactat     1740

agagaaagcc aggcagggtg cggcaagagt cacatcttgg ctcgggagac aactcagaac     1800

cacagggaag aagttggaga gaggaagcaa aacctggttc ggtgcctatg ccctgtcacc     1860

ttactgcaat gtaacaagga aaatagggta catatggtac acgaacaatt gcactccggc     1920

atgcctccca aaaaacacaa aaataatagg cccaggaaag tttgacacca atgcagaaga     1980

cgggaagatt cttcatgaaa tggggggcca cctatcagaa ttcttgttgc tttctctggt     2040

agtcctgtct gacttcgccc cagaaacggc cagtacatta tacctaatct tacactatgc     2100

aatccctcag tcccgtgacg aacccgaggt ttgcgataca aaccagctca acctaacagt     2160

gggacttagg acagaagatg tggtaccatc atcagtctgg aatattggca aatatgtgtg     2220

tgttagacca gattggtggc cgtatgaaac taaggtggct ctactgtttg aagaggcggg     2280

acaggtcata aagttagctc tacgggcact gagggattta actagagtct ggaacagtgc     2340

atcaactact gcgttcctca tctgcttgat aaaaatatta agaggacagg ttgtgcaagg     2400

tataatatgg ctgctgctgg tgactggggc acaagggcgg ttgtcctgca aggaagacta     2460

caggtatgcg atatcaaaga ccaatgagat agggccgcta gcagctaggg acctcaccac     2520

cacctggaaa gaatataacc atggtttgca gctggatgac gggactgtca gggccatttg     2580

cactgcaggg tcctttaaag ttatagcact taatgtggtc agtaggaggt acctggcatc     2640

attacacaag agggctttac ccacttcagt aacatttgaa ctcctatttg atgggactag     2700

tccagcaatt gaggagatgg gagatgactt tggatttggg ctgtgccctt ttgacacaac     2760

ccccgtggtc aaagggaagt acaataccac tttattaaac ggtagtgctt tctatctagt     2820

ctgcccaata ggatggacgg gtgtcataga gtgcacggca gtaagcccta caaccttgag     2880

aacagaagtg gtgaagacct tcaagagaga gaagcctttc ccacacagag tgggttgcgt     2940

gaccactgtt gtagaaaaag aagacctgtt ctactgcaag tgggggggta attggacatg     3000

tgtaaaaggc aacccggtga cctacatggg ggggcaagta aaacaatgca gatggtgcgg     3060

ttttgacttc aaggagcccg atgggctccc acactacccc ataggcaagt gcatcctagc     3120

aaatgagacg ggttacaggg tagtggattc cacagactgc aatagagatg gcgtcgttat     3180

cagcactgaa ggtgaacacg agtgcttgat tggcaacacc accgtcaagg tgcacgcgtt     3240

ggatggaaga ctgggcccta tgccgtgcag acccaaagaa atcgtctcta gcgcaggacc     3300

tgtaaggaaa acttcctgca ccttcaacta cacaaagaca ctaagaaaca agtactatga     3360

acccagggac agctatttcc agcaatatat gcttaagggc gagtaccaat actggtttga     3420

tctggacgtg accgaccacc acacagacta ctttgccgaa tttgttgtct tggtggtagt     3480

ggcactatta ggggggaggt acgtcctatg gctaatagtg acctatgtaa ttttaacaga     3540

gcaactcgct gccggtttac agctgggcca aggcgaggta gtactgatag ggaacttaat     3600

tacccacacg gacaatgagg tagtggtata cttcttactg ctctacctaa taataagaga     3660

cgagcctata aagaaatgga tactactgct gtttcatgcc atgaccaaca acccagttaa     3720

gaccatgaca gtagcattgc tgatgatcag tggggtcgcc aagggtggga aaacagatgg     3780

tggttggcag aggcagccgg agaccaattt tgacattcaa ctcgcactgg cagttatagt     3840

agtcgttgtg atgttactgg caaagagaga cccgactact tttcccctgg tgatcacagt     3900

ggcaacctta agaacagcta agataaccaa tggtttcagc acagatctag ctatagccac     3960

agtgtcggca gctttgctaa cctggactta tatcagtgac tactacaaat ataagacttg     4020

gctacagtac ctcatcagca cggtgactgg gatcttccta ataagggtac tgaagggaat     4080

aggcgagcta gacatgcacg ccccaacttt gccatctcac agaccccttt tctacatcct     4140

cgtgtacctc atctccactg ctgtggtgac tagatggaac ctggacgtag ccggactgct     4200

gctacagtgt gtcccaacac ttctaatggt gttcacgatg tgggctgaca ttctcaccct     4260

aatcctcgtg ttacccactt atgaactggc aaagttgtat taccttaagg aagtgaagat     4320

cggaaccgaa agaggatggc tgtggaaaac taactataag agggtaaatg acatctatga     4380

agtcgaccaa gctggcgagg gggtctacct cttcccttcg aaacaaaaga ctagtgctat     4440

aacaagcacc atgttgccat tgatcaaagc catactcatt agctgcatca gtaacaagtg     4500

gcaactcata tatttactgt acctgatatt cgaagtgtcc tactaccttc acaagaaagt     4560

catagatgaa atagctggtg ggaccaactt cgtttcaagg ctagtggcag ccttaattga     4620

agttaattgg gccttcgaca atgaagaagt taaaggccta aagaagttct ttttgctgtc     4680

cagtagagtt aaagaattgg tcatcaaaca caaagtgagg aatgaagtag tggcccgctg     4740

gttcggagat gaagagatct atgggatgcc caagttgatc ggcttagtca aggcagcaac     4800

tctaagtaaa aataaacact gtatcttgtg caccgtctgc gaggacagag attggagagg     4860

agaaacctgc ccaaaatgtg ggcgtttcgg accaccagtg atctgtggta tgaccctagc     4920

cgacttcgag gagaagcatt ataagaggat attcatcagg gaggaccaat cagatggacc     4980

gctcagggag gagcgtgcag ggtacttaca gtacagagct aggggtcaac tgtttctgag     5040

gaatctccca gtgttggcga caaaagtcaa gatgctcctg gttggtaacc tcgggacgga     5100

ggttggggat ttggagcacc ttggctgggt gcttagaggg cctgctgtct gcaagaaggt     5160

tactgaacat gaaaagtgtg ctacgtctat aatggataag ttgactgctt tcttcggcgt     5220

tatgccaaga ggtaccaccc ccagagcccc cgtgagattt cccacctccc tcctaaagat     5280

aagaagaggg ctagagacgg gttgggctta cacacatcaa ggtggcatta gctcagttga     5340

ccatgtgact tgtgggaaag acttgctggt gtgtgacact atgggccgga caagggtcgt     5400

ttgccaatca aataataaga tgactgacga atccgaatac ggggtcaaaa ccgactcagg     5460

gtgcccagaa ggggccagat gttatgtgtt caaccctgag gcagttaaca tatcaggcac     5520

taaaggggcc atggtccact tacaaaaaac tggtggggag ttcacctgcg taacagcatc     5580

aggaaccccg gccttctttg atctcaagaa cctcaagggc tggtcagggc taccgatatt     5640

cgaagcatcg agtggaaggg tagtcggaag ggtcaaggtc gggaagaacg atgactctaa     5700

accaaccaaa ctcatgagtg ggatacaaac ggtctctaaa agtgccactg acctgacgga     5760

gatggtaaag aagataacaa ctatgaacag gggagagttc agacagataa ccttggccac     5820

aggtgctggg aaaactacag agctccccag gtcagtcata gaagagatag ggagacacaa     5880

aagggtgttg gtattgatcc ccttgagggc cgcagcagaa tcagtatacc aatatatgag     5940

gcagaaacac ccaagtatag cattcaacct gaggataggg gagatgaagg aaggtcacat     6000

ggccacgggg ataacctatg cctcctacgg ttacttttgc cagatgccac aacctaagct     6060

gagggccgca atggtagagt actcctacat ctttctagat gagtaccatt gtgccacccc     6120

agaacaactg gctatcatgg ggaagatcca cagattctca gagaacctgc gggtggtagc     6180

tatgacagcg acaccagcag ggacagtaac aactactggg cagaaacacc ctatagagga     6240

gttcatagcc ccggaagtaa tgaaaggaga agacttaggt tcagagtact tagacattgc     6300

cggactaaag ataccagtag aggagatgaa gaacaacatg ctagtttttg taccaactag     6360

gaatatggcg gtagaggcgg caaagaaact gaaagctaaa ggatacaact caggctatta     6420

ctacagtggt gaggatccat ctaacctgag ggtagtcaca tcgcagtccc catacgtggt     6480

tgtagcgacc aacgcgatag aatcaggcgt cactctcccg gaccttgacg tggtcgttga     6540

cacgggactc aagtgtgaga aaagaatccg attgtcaccc aagatgcctt tcatagtgac     6600

tggcctaaaa agaatggctg ttaccattgg ggaacaagcc cagagaagag ggagggttgg     6660

aagagtaaag cccgggagat actacaggag ccaagaaacc cctgtcggct ctaaggacta     6720

ccactacgat ttattgcaag cccagaggta cggtatagaa gatgggataa atatcaccaa     6780

atccttcaga gaaatgaact atgattggag cctctatgag gaagatagcc tgatgataac     6840

acaattggaa atcctcaaca atctactgat atcagaggag ctgccggtgg cagtaaaaaa     6900

tataatggct aggactgacc acccagaacc aattcaacta gcatataata gctacgagac     6960

acaagtgcct gtgttgttcc caaaaataag aaatggagag gtgactgaca cttacgatac     7020

ttacaccttc atcaatgcaa gaaaattggg agatgatgta cctccctacg tgtatgccac     7080

agaagatgag gacttggcag tggaactgtt gggcctagat tggccggacc ctgggaacca     7140

aggcactgtg gaggccggca gagcactaaa acaggtggtc ggtctatcaa cagccgagaa     7200

tgccctgtta gtagccttgt ttggctacgt agggtaccag gccctctcaa agaggcatat     7260

acctgtggtc acagacatat actcagttga agatcacagg ctagaggaca ccacacacct     7320

acagtacgct ccgaatgcca tcaagacgga ggggaaggag actgaattga aggagttggc     7380

tcagggggat gtgcagagat gcgtggaagc gatgaccaat tacgcgagag ggggcatcca     7440

atttatgaag tcacaggcac tgcaggtgag agaaaccccc acttataaag agacaatgaa     7500

tactgtagca gactatgtga aaaagtttat cgaggcactg tctgatagca aggaagacat     7560

cttgaaatat gggctgtggg gcgtacatac ggccttgtac aagagcattg gtgccaggct     7620

tggtcacgaa accgcgttcg caaccctagc cgtgaaatgg ctggcatttg ggggggaatc     7680

aatagcagat catataaaac aagcggctac agacttggtc gtctactata tcatcaacag     7740

acctcagttc ccaggagaca cagagacaca acaggagggg agaaattttg tggccagcct     7800

actggtctca gccctagcaa cttacacata taaaagctgg aactataata acctgtccaa     7860

gatagtagaa ccggctttgg ccaccctgcc ctatgccgct aaagccctta aattatttgc     7920

ccctaccagg ctagagagcg tcgtcatatt gagcaccgca atctacaaaa catacctatc     7980

aatcaggcga ggcaaaagcg atggattgct aggtacaggg gttagtgcgg ctatggagat     8040

tatgtcacaa aatccggtat cagtgggcat agcagttatg ctgggggttg gggctgtagc     8100

agcacacaac gcaattgaag ccagtgagca gaagagaaca ctacttatga aagtttttgt     8160

aaagaacttc ttggaccaag cagccacaga tgaactagtc aaagagagcc ctgagaaaat     8220

aataatggcc ttgtttgaag cagtgcaaac agtaggcaat cctcttaggc tagtgtacca     8280

cctttacggg gttttttata aagggtggga agcaaaagag ttggcccaaa ggacagccgg     8340

caggaatctt ttcaccttga taatgtttga ggccgtggaa ctattgggag tagatagcga     8400

aggaaaaatc cgccaactat cgagtaatta catattagag ctcctgtata agttccgtga     8460

cagtatcaaa tctagtgtga gggagatagc aatcagctgg gcccctgccc cctttagttg     8520

cgattggaca ccaacagatg acagaatagg gcttccccat aacaattacc tccaaatgga     8580

gacaagatgc ccttgtggct acaggatgaa agcagtaaaa acctgtgctg gggagttgag     8640

acttctggaa gagggaggtt cattcctctg caggaataaa ttcggtagag ggtcacggaa     8700

ctatagggtg acaaaatact atgatgacaa tttatcagaa ataaaaccag tgataagaat     8760

ggaaggacat gtggaactat attataaggg ggccactatc aaactggact ttaacaacag     8820

taaaacagta ctggcaaccg acaaatggga ggttgaccat tccaccctgg tcagggcgct     8880

caagaggcac acaggggctg ggtaccaagg agcgtatatg ggtgagaaac ctaaccacaa     8940

acatctgata gagagagact gtgcaacgat cacaaaagac aaggtttact tcatcaagat     9000

gaagaggggg tgtgcgttca cttatgactt gtccctccac aacctcaccc ggttaatcga     9060

attggtacac aaaaacgacc tggaagatag agaaatccct gctgttacgg ttacaacctg     9120

gctggcctac acatttgtga atgaagacat agggaccata aaaccagttt ttggggaaaa     9180

agtaacaccg gaaaaacagg aggaggtagc cttgcagcct gctgtggtgg tggacacaac     9240

agatgtggcc gtgaccgtgg tgggggaaac ctctactatg actacagggg agaccccaac     9300

ggcattcacc agcttaggtt cagactctaa agttcaacaa gttctgaagt taggggtgga     9360

tgagggtcaa taccccgggc ccagtcagca gagagcaagc ttgctcgacg ctatacaagg     9420

cgtggatgaa aggccctcgg tattgatatt gggatctgat aaggccacct ccaatagggt     9480

gaagaccgca aagaatgtca agatattcag gagcagagac cccctggaac tgagagaaat     9540

gatgagaaga gggaagatcc tggtcatagc cctatgtaag gtcgacactg ctctactgaa     9600

atttgttgat tacaaaggca ccttcctgac cagagaaacc ctagaggcat taagtttggg     9660

taagcctaag aaaaaaaaca taaccaagac agaggcacaa tggttgttgt gcctcgaaaa     9720

ccaaatagaa gagctgcctg actggttcgc agctgaggag cccgtatttc tggaagccaa     9780

catcaaacgt gacaagtatc acctagtggg ggatatagct actatcaaag aaaaagctaa     9840

acaactgggg gcaacagact ccacaaagat atcaaaagag gttggagcta aagtatattc     9900

tatgaagctg agtaactggg tgatacaaga agagaataaa cagggcagct tagccccttt     9960

gtttgaagag ctcctgcaac agtgcccacc tgggggccag aataaaacca cacatatggt    10020

ctcagcctac caactggctc aagggaactg gatgccagtt ggttgtcacg tgttcatggg    10080

gaccataccc gccagaagaa ccaagaccca tccctatgag gcatacgtca agctgaggga    10140

gttggtagat gaatataaga tgaagacgct atgtggcggt tcaggcctaa gtaagcacaa    10200

cgaatgggta attcgtaaga tcaagcatca agggaacctg aggaccaaac acatgttgaa    10260

ccccgggaag gttgcagagc aactgcttag agaaggacac agacacaatg tatataataa    10320

gactataggc tcagtgatga cagcaactgg tatcaggctg gaaaagttac ccgtggtcag    10380

ggcccaaaca gacacaacca acttccatca agcaataagg gataaaatag acaaggaaga    10440

gaacttacag actccaggct tacacaagaa gttaatggaa gtcttcaatg cattaaaaag    10500

acccgatctt gaggcctctt acgacgctgt ggagtgggag gaattggaga aaggaataaa    10560

taggaagggt gctgcaggtt tctttgaaca caagaatata ggagaggttc tggattcaga    10620

aaaaaacaag gttgaagaga tcatagacag tttgagaaaa ggtaggagta tcaggtacta    10680

tgaaactgca atcccaaaaa acgagaagag ggacgtcaat gatgactgga ctgccggtga    10740

ctttgtagac gagaaaaagc ccagggtgat acaataccct gaggctaaaa ccaggttggc    10800

catcactaaa gtaatgtaca agtgggtgaa gcagaaacca gtagtcatac ccggctatga    10860

aggtaagaca cctctgttcc aaatctttga caaagtgaag aaagaatggg accaattcca    10920

aaatccagtg gctgtgagct ttgacaccaa agcgtgggac acccaggtga ctacaggaga    10980

cctggaacta ataagggata tacagaagtt ctacttcaag aagaagtggc acaaattcat    11040

tgacacccta accatgcaca tgtcagaagt acccgtaatt agtgccgacg gggaggtgta    11100

cataaggaag gggcagagag gcagtggaca acctgatacg agcgcaggca acagcatgtt    11160

gaatgtatta acaatggttt atgccttctg tgaggccacg ggagtgccct ataagagttt    11220

tgacagagtg gcaaagatcc acgtctgcgg ggatgatggt ttcttgatca ctgaaagggc    11280

tcttggtgaa aaattttcga gtaaaggagt ccagatccta tatgaagctg gtaagcccca    11340

aaaaattaca gaaggggata agatgaaagt ggcctaccag tttgatgaca tcgagttctg    11400

ctcccataca ccagtgcaag taaggtggtc agacaatact tccagttata tgccggggag    11460

gaacacgact acaatcctgg caaaaatggc tacaaggtta gattccagtg gtgagagggg    11520

cactatagca tatgagaagg cggtggcgtt tagcttctta ttgatgtact cctggaaccc    11580

actgatcaga aggatatgct tactggtgtt gtcaactgaa ctgcaagtga gaccagggaa    11640

gtcaaccacc tattactatg aaggggaccc aatttctgct tacaaggagg tcataggcca    11700

taatctcttt gaccttaaaa gaacaagctt tgagaaacta gctaagttaa atcttagtat    11760

gtccacactc ggggtatgga ccagacacac cagcaaaaga ttactacaag actgtgtcaa    11820

cgtcggcact aaagagggca actggctggt taatgcagac agactggtga gtagcaagac    11880

aggaaatagg tatatacctg gagagggtca tacccagcaa gggaaacatt atgaagaact    11940

gatattggca aggaagccga tcagcaattt tgaagggact gatagataca atttgggccc    12000

aatagtcaac gtagtgttga ggaggctgag agtcatgatg atggctctta taggaagggg    12060

ggtgtaagca tggccggccc ttaaccgggc cctatcagta gaaccctgtt gtaaataaca    12120

ctaacttatt atttatttaa atactattat ttatttattt atttatttat tgaatgagca    12180

aggattggta caaactacct catgttacca cactacactc attttaacag cactttagct    12240

ggagggaaaa tcctgacgtc catagttgga ctaaggtaat ttcctaacgg ccc           12293


<210>  4
<211>  12290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-ddErnsHC-KARD

<400>  4
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca aaacaaaatt ccgatttggc       60

ctagggcacc cctccagcga cggccgaact gggctagcca tgcccacagt aggactagca      120

aacggaggga ctagccgtag tggcgagctc cctgggtggt ctaagtcctg agtacaggac      180

agtcgtcagt agttcgacgt gagcaggagc ccacctcgag atgctatgtg gacgagggca      240

tgcccaagac acaccttaac cctggcgggg gtcgccaggg tgaaatcaca ccatgtgatg      300

ggggtacgac ctgatagggc gctgcagagg cccactaaca ggctagtata aaaatctctg      360

ctgtacatgg cacatggagt tgaatcattt tgaactattg tataaaacaa acaaacaaaa      420

accaatggga gtggaggaac cggtgtatga catcgcaggg agaccattat ttggggaccc      480

aagtgaggta cacccacaat caacactgaa gctaccacac gacaggggaa gaggtaatat      540

cagaactaca ctgaaggacc tacctaggaa aggcgactgc aggagtggaa accacctagg      600

accagttagt gggatatacg taaagcctgg ccctgtcttc tatcaggact acatgggccc      660

tgtctaccat agagccccat tagagttttt tggtgaggcc caattttgtg aggtgaccaa      720

gaggataggt agggtgacgg gtagtgacgg aaagctctac cacatatatg tgtgcatcga      780

cggttgcata ctgttgaagt tagccaaaag gggcgcgccc agatccctaa agtggactag      840

gaacttcacc gactgtccac tgtgggtcac tagttgttct gatgatggca caggtgacag      900

caaggataaa aagccagaca ggatgaacaa gggtaaatta aagatagccc caaaagagca      960

tgagaaggac agtaagacca agccacctga tgctacaatt gtggtagagg gagtaaaata     1020

ccaagtaaaa aagaaaggca aagtcaaagg gaagaacact caagatggcc tgtaccataa     1080

taagaacaaa ccaccagagt ccaggaagaa actagaaaaa gccctattgg cctgggcagt     1140

gatagcaata gtgctgtacc agcctgtagc agccgagaat ataacccaat ggaacctgag     1200

tgacaacggc acaagcggca tccagcaagc tatgtatctc agaggggtca ataggagctt     1260

gcatgggatc tggcctgaaa aaatatgcaa gggggtccct actcatctgg ccactgacac     1320

ggaactgaca gagatacgcg ggatgatgga cgccagtgag aggacgaact acacgtgttg     1380

taggttgcag agacacgaat ggaacaaagg ctggtgcaac tggtacaaca tagacccctg     1440

gattcagtta atgaacagga cccaagcaaa tttgacagaa ggccctccag ataaagagtg     1500

tgccgtgact tgcaggtatg acaaaaatac cgatgttaac gtggtcaccc aggccaggaa     1560

tagacctact actctgactg gctgcaagaa agggaaaaat ttttcatttg caggtacggt     1620

catagagggc ccatgcaatt tcaacgtatc cgtggaggac atcttatatg gcgaccatga     1680

gggcagcctg ttccaggaca cggctctgta cctattagat ggaatgacca acactataga     1740

gaaagccagg cagggtgcgg caagagtcac atcttggctc gggagacaac tcagaaccac     1800

agggaagaag ttggagagag gaagcaaaac ctggttcggt gcctatgccc tgtcacctta     1860

ctgcaatgta acaaggaaaa tagggtacat atggtacacg aacaattgca ctccggcatg     1920

cctcccaaaa aacacaaaaa taataggccc aggaaagttt gacaccaatg cagaagacgg     1980

gaagattctt catgaaatgg ggggccacct atcagaattc ttgttgcttt ctctggtagt     2040

cctgtctgac ttcgccccag aaacggccag tacattatac ctaatcttac actatgcaat     2100

ccctcagtcc cgtgacgaac ccgaggtttg cgatacaaac cagctcaacc taacagtggg     2160

acttaggaca gaagatgtgg taccatcatc agtctggaat attggcaaat atgtgtgtgt     2220

tagaccagat tggtggccgt atgaaactaa ggtggctcta ctgtttgaag aggcgggaca     2280

ggtcataaag ttagctctac gggcactgag ggatttaact agagtctgga acagtgcatc     2340

aactactgcg ttcctcatct gcttgataaa aatattaaga ggacaggttg tgcaaggtat     2400

aatatggctg ctgctggtga ctggggcaca agggcggttg tcctgcaagg aagactacag     2460

gtatgcgata tcaaagacca atgagatagg gccgctagca gctagggacc tcaccaccac     2520

ctggaaagaa tataaccatg gtttgcagct ggatgacggg actgtcaggg ccatttgcac     2580

tgcagggtcc tttaaagtta tagcacttaa tgtggtcagt aggaggtacc tggcatcatt     2640

acacaagagg gctttaccca cttcagtaac atttgaactc ctatttgatg ggactagtcc     2700

agcaattgag gagatgggag atgactttgg atttgggctg tgcccttttg acacaacccc     2760

cgtggtcaaa gggaagtaca ataccacttt attaaacggt agtgctttct atctagtctg     2820

cccaatagga tggacgggtg tcatagagtg cacggcagta agccctacaa ccttgagaac     2880

agaagtggtg aagaccttca agagagagaa gcctttccca cacagagtgg gttgcgtgac     2940

cactgttgta gaaaaagaag acctgttcta ctgcaagtgg gggggtaatt ggacatgtgt     3000

aaaaggcaac ccggtgacct acatgggggg gcaagtaaaa caatgcagat ggtgcggttt     3060

tgacttcaag gagcccgatg ggctcccaca ctaccccata ggcaagtgca tcctagcaaa     3120

tgagacgggt tacagggtag tggattccac agactgcaat agagatggcg tcgttatcag     3180

cactgaaggt gaacacgagt gcttgattgg caacaccacc gtcaaggtgc acgcgttgga     3240

tggaagactg ggccctatgc cgtgcagacc caaagaaatc gtctctagcg caggacctgt     3300

aaggaaaact tcctgcacct tcaactacac aaagacacta agaaacaagt actatgaacc     3360

cagggacagc tatttccagc aatatatgct taagggcgag taccaatact ggtttgatct     3420

ggacgtgacc gaccaccaca cagactactt tgccgaattt gttgtcttgg tggtagtggc     3480

actattaggg gggaggtacg tcctatggct aatagtgacc tatgtaattt taacagagca     3540

actcgctgcc ggtttacagc tgggccaagg cgaggtagta ctgataggga acttaattac     3600

ccacacggac aatgaggtag tggtatactt cttactgctc tacctaataa taagagacga     3660

gcctataaag aaatggatac tactgctgtt tcatgccatg accaacaacc cagttaagac     3720

catgacagta gcattgctga tgatcagtgg ggtcgccaag ggtgggaaaa cagatggtgg     3780

ttggcagagg cagccggaga ccaattttga cattcaactc gcactggcag ttatagtagt     3840

cgttgtgatg ttactggcaa agagagaccc gactactttt cccctggtga tcacagtggc     3900

aaccttaaga acagctaaga taaccaatgg tttcagcaca gatctagcta tagccacagt     3960

gtcggcagct ttgctaacct ggacttatat cagtgactac tacaaatata agacttggct     4020

acagtacctc atcagcacgg tgactgggat cttcctaata agggtactga agggaatagg     4080

cgagctagac atgcacgccc caactttgcc atctcacaga ccccttttct acatcctcgt     4140

gtacctcatc tccactgctg tggtgactag atggaacctg gacgtagccg gactgctgct     4200

acagtgtgtc ccaacacttc taatggtgtt cacgatgtgg gctgacattc tcaccctaat     4260

cctcgtgtta cccacttatg aactggcaaa gttgtattac cttaaggaag tgaagatcgg     4320

aaccgaaaga ggatggctgt ggaaaactaa ctataagagg gtaaatgaca tctatgaagt     4380

cgaccaagct ggcgaggggg tctacctctt cccttcgaaa caaaagacta gtgctataac     4440

aagcaccatg ttgccattga tcaaagccat actcattagc tgcatcagta acaagtggca     4500

actcatatat ttactgtacc tgatattcga agtgtcctac taccttcaca agaaagtcat     4560

agatgaaata gctggtggga ccaacttcgt ttcaaggcta gtggcagcct taattgaagt     4620

taattgggcc ttcgacaatg aagaagttaa aggcctaaag aagttctttt tgctgtccag     4680

tagagttaaa gaattggtca tcaaacacaa agtgaggaat gaagtagtgg cccgctggtt     4740

cggagatgaa gagatctatg ggatgcccaa gttgatcggc ttagtcaagg cagcaactct     4800

aagtaaaaat aaacactgta tcttgtgcac cgtctgcgag gacagagatt ggagaggaga     4860

aacctgccca aaatgtgggc gtttcggacc accagtgatc tgtggtatga ccctagccga     4920

cttcgaggag aagcattata agaggatatt catcagggag gaccaatcag atggaccgct     4980

cagggaggag cgtgcagggt acttacagta cagagctagg ggtcaactgt ttctgaggaa     5040

tctcccagtg ttggcgacaa aagtcaagat gctcctggtt ggtaacctcg ggacggaggt     5100

tggggatttg gagcaccttg gctgggtgct tagagggcct gctgtctgca agaaggttac     5160

tgaacatgaa aagtgtgcta cgtctataat ggataagttg actgctttct tcggcgttat     5220

gccaagaggt accaccccca gagcccccgt gagatttccc acctccctcc taaagataag     5280

aagagggcta gagacgggtt gggcttacac acatcaaggt ggcattagct cagttgacca     5340

tgtgacttgt gggaaagact tgctggtgtg tgacactatg ggccggacaa gggtcgtttg     5400

ccaatcaaat aataagatga ctgacgaatc cgaatacggg gtcaaaaccg actcagggtg     5460

cccagaaggg gccagatgtt atgtgttcaa ccctgaggca gttaacatat caggcactaa     5520

aggggccatg gtccacttac aaaaaactgg tggggagttc acctgcgtaa cagcatcagg     5580

aaccccggcc ttctttgatc tcaagaacct caagggctgg tcagggctac cgatattcga     5640

agcatcgagt ggaagggtag tcggaagggt caaggtcggg aagaacgatg actctaaacc     5700

aaccaaactc atgagtggga tacaaacggt ctctaaaagt gccactgacc tgacggagat     5760

ggtaaagaag ataacaacta tgaacagggg agagttcaga cagataacct tggccacagg     5820

tgctgggaaa actacagagc tccccaggtc agtcatagaa gagataggga gacacaaaag     5880

ggtgttggta ttgatcccct tgagggccgc agcagaatca gtataccaat atatgaggca     5940

gaaacaccca agtatagcat tcaacctgag gataggggag atgaaggaag gtcacatggc     6000

cacggggata acctatgcct cctacggtta cttttgccag atgccacaac ctaagctgag     6060

ggccgcaatg gtagagtact cctacatctt tctagatgag taccattgtg ccaccccaga     6120

acaactggct atcatgggga agatccacag attctcagag aacctgcggg tggtagctat     6180

gacagcgaca ccagcaggga cagtaacaac tactgggcag aaacacccta tagaggagtt     6240

catagccccg gaagtaatga aaggagaaga cttaggttca gagtacttag acattgccgg     6300

actaaagata ccagtagagg agatgaagaa caacatgcta gtttttgtac caactaggaa     6360

tatggcggta gaggcggcaa agaaactgaa agctaaagga tacaactcag gctattacta     6420

cagtggtgag gatccatcta acctgagggt agtcacatcg cagtccccat acgtggttgt     6480

agcgaccaac gcgatagaat caggcgtcac tctcccggac cttgacgtgg tcgttgacac     6540

gggactcaag tgtgagaaaa gaatccgatt gtcacccaag atgcctttca tagtgactgg     6600

cctaaaaaga atggctgtta ccattgggga acaagcccag agaagaggga gggttggaag     6660

agtaaagccc gggagatact acaggagcca agaaacccct gtcggctcta aggactacca     6720

ctacgattta ttgcaagccc agaggtacgg tatagaagat gggataaata tcaccaaatc     6780

cttcagagaa atgaactatg attggagcct ctatgaggaa gatagcctga tgataacaca     6840

attggaaatc ctcaacaatc tactgatatc agaggagctg ccggtggcag taaaaaatat     6900

aatggctagg actgaccacc cagaaccaat tcaactagca tataatagct acgagacaca     6960

agtgcctgtg ttgttcccaa aaataagaaa tggagaggtg actgacactt acgatactta     7020

caccttcatc aatgcaagaa aattgggaga tgatgtacct ccctacgtgt atgccacaga     7080

agatgaggac ttggcagtgg aactgttggg cctagattgg ccggaccctg ggaaccaagg     7140

cactgtggag gccggcagag cactaaaaca ggtggtcggt ctatcaacag ccgagaatgc     7200

cctgttagta gccttgtttg gctacgtagg gtaccaggcc ctctcaaaga ggcatatacc     7260

tgtggtcaca gacatatact cagttgaaga tcacaggcta gaggacacca cacacctaca     7320

gtacgctccg aatgccatca agacggaggg gaaggagact gaattgaagg agttggctca     7380

gggggatgtg cagagatgcg tggaagcgat gaccaattac gcgagagggg gcatccaatt     7440

tatgaagtca caggcactgc aggtgagaga aacccccact tataaagaga caatgaatac     7500

tgtagcagac tatgtgaaaa agtttatcga ggcactgtct gatagcaagg aagacatctt     7560

gaaatatggg ctgtggggcg tacatacggc cttgtacaag agcattggtg ccaggcttgg     7620

tcacgaaacc gcgttcgcaa ccctagccgt gaaatggctg gcatttgggg gggaatcaat     7680

agcagatcat ataaaacaag cggctacaga cttggtcgtc tactatatca tcaacagacc     7740

tcagttccca ggagacacag agacacaaca ggaggggaga aattttgtgg ccagcctact     7800

ggtctcagcc ctagcaactt acacatataa aagctggaac tataataacc tgtccaagat     7860

agtagaaccg gctttggcca ccctgcccta tgccgctaaa gcccttaaat tatttgcccc     7920

taccaggcta gagagcgtcg tcatattgag caccgcaatc tacaaaacat acctatcaat     7980

caggcgaggc aaaagcgatg gattgctagg tacaggggtt agtgcggcta tggagattat     8040

gtcacaaaat ccggtatcag tgggcatagc agttatgctg ggggttgggg ctgtagcagc     8100

acacaacgca attgaagcca gtgagcagaa gagaacacta cttatgaaag tttttgtaaa     8160

gaacttcttg gaccaagcag ccacagatga actagtcaaa gagagccctg agaaaataat     8220

aatggccttg tttgaagcag tgcaaacagt aggcaatcct cttaggctag tgtaccacct     8280

ttacggggtt ttttataaag ggtgggaagc aaaagagttg gcccaaagga cagccggcag     8340

gaatcttttc accttgataa tgtttgaggc cgtggaacta ttgggagtag atagcgaagg     8400

aaaaatccgc caactatcga gtaattacat attagagctc ctgtataagt tccgtgacag     8460

tatcaaatct agtgtgaggg agatagcaat cagctgggcc cctgccccct ttagttgcga     8520

ttggacacca acagatgaca gaatagggct tccccataac aattacctcc aaatggagac     8580

aagatgccct tgtggctaca ggatgaaagc agtaaaaacc tgtgctgggg agttgagact     8640

tctggaagag ggaggttcat tcctctgcag gaataaattc ggtagagggt cacggaacta     8700

tagggtgaca aaatactatg atgacaattt atcagaaata aaaccagtga taagaatgga     8760

aggacatgtg gaactatatt ataagggggc cactatcaaa ctggacttta acaacagtaa     8820

aacagtactg gcaaccgaca aatgggaggt tgaccattcc accctggtca gggcgctcaa     8880

gaggcacaca ggggctgggt accaaggagc gtatatgggt gagaaaccta accacaaaca     8940

tctgatagag agagactgtg caacgatcac aaaagacaag gtttacttca tcaagatgaa     9000

gagggggtgt gcgttcactt atgacttgtc cctccacaac ctcacccggt taatcgaatt     9060

ggtacacaaa aacgacctgg aagatagaga aatccctgct gttacggtta caacctggct     9120

ggcctacaca tttgtgaatg aagacatagg gaccataaaa ccagtttttg gggaaaaagt     9180

aacaccggaa aaacaggagg aggtagcctt gcagcctgct gtggtggtgg acacaacaga     9240

tgtggccgtg accgtggtgg gggaaacctc tactatgact acaggggaga ccccaacggc     9300

attcaccagc ttaggttcag actctaaagt tcaacaagtt ctgaagttag gggtggatga     9360

gggtcaatac cccgggccca gtcagcagag agcaagcttg ctcgacgcta tacaaggcgt     9420

ggatgaaagg ccctcggtat tgatattggg atctgataag gccacctcca atagggtgaa     9480

gaccgcaaag aatgtcaaga tattcaggag cagagacccc ctggaactga gagaaatgat     9540

gagaagaggg aagatcctgg tcatagccct atgtaaggtc gacactgctc tactgaaatt     9600

tgttgattac aaaggcacct tcctgaccag agaaacccta gaggcattaa gtttgggtaa     9660

gcctaagaaa aaaaacataa ccaagacaga ggcacaatgg ttgttgtgcc tcgaaaacca     9720

aatagaagag ctgcctgact ggttcgcagc tgaggagccc gtatttctgg aagccaacat     9780

caaacgtgac aagtatcacc tagtggggga tatagctact atcaaagaaa aagctaaaca     9840

actgggggca acagactcca caaagatatc aaaagaggtt ggagctaaag tatattctat     9900

gaagctgagt aactgggtga tacaagaaga gaataaacag ggcagcttag cccctttgtt     9960

tgaagagctc ctgcaacagt gcccacctgg gggccagaat aaaaccacac atatggtctc    10020

agcctaccaa ctggctcaag ggaactggat gccagttggt tgtcacgtgt tcatggggac    10080

catacccgcc agaagaacca agacccatcc ctatgaggca tacgtcaagc tgagggagtt    10140

ggtagatgaa tataagatga agacgctatg tggcggttca ggcctaagta agcacaacga    10200

atgggtaatt cgtaagatca agcatcaagg gaacctgagg accaaacaca tgttgaaccc    10260

cgggaaggtt gcagagcaac tgcttagaga aggacacaga cacaatgtat ataataagac    10320

tataggctca gtgatgacag caactggtat caggctggaa aagttacccg tggtcagggc    10380

ccaaacagac acaaccaact tccatcaagc aataagggat aaaatagaca aggaagagaa    10440

cttacagact ccaggcttac acaagaagtt aatggaagtc ttcaatgcat taaaaagacc    10500

cgatcttgag gcctcttacg acgctgtgga gtgggaggaa ttggagaaag gaataaatag    10560

gaagggtgct gcaggtttct ttgaacacaa gaatatagga gaggttctgg attcagaaaa    10620

aaacaaggtt gaagagatca tagacagttt gagaaaaggt aggagtatca ggtactatga    10680

aactgcaatc ccaaaaaacg agaagaggga cgtcaatgat gactggactg ccggtgactt    10740

tgtagacgag aaaaagccca gggtgataca ataccctgag gctaaaacca ggttggccat    10800

cactaaagta atgtacaagt gggtgaagca gaaaccagta gtcatacccg gctatgaagg    10860

taagacacct ctgttccaaa tctttgacaa agtgaagaaa gaatgggacc aattccaaaa    10920

tccagtggct gtgagctttg acaccaaagc gtgggacacc caggtgacta caggagacct    10980

ggaactaata agggatatac agaagttcta cttcaagaag aagtggcaca aattcattga    11040

caccctaacc atgcacatgt cagaagtacc cgtaattagt gccgacgggg aggtgtacat    11100

aaggaagggg cagagaggca gtggacaacc tgatacgagc gcaggcaaca gcatgttgaa    11160

tgtattaaca atggtttatg ccttctgtga ggccacggga gtgccctata agagttttga    11220

cagagtggca aagatccacg tctgcgggga tgatggtttc ttgatcactg aaagggctct    11280

tggtgaaaaa ttttcgagta aaggagtcca gatcctatat gaagctggta agccccaaaa    11340

aattacagaa ggggataaga tgaaagtggc ctaccagttt gatgacatcg agttctgctc    11400

ccatacacca gtgcaagtaa ggtggtcaga caatacttcc agttatatgc cggggaggaa    11460

cacgactaca atcctggcaa aaatggctac aaggttagat tccagtggtg agaggggcac    11520

tatagcatat gagaaggcgg tggcgtttag cttcttattg atgtactcct ggaacccact    11580

gatcagaagg atatgcttac tggtgttgtc aactgaactg caagtgagac cagggaagtc    11640

aaccacctat tactatgaag gggacccaat ttctgcttac aaggaggtca taggccataa    11700

tctctttgac cttaaaagaa caagctttga gaaactagct aagttaaatc ttagtatgtc    11760

cacactcggg gtatggacca gacacaccag caaaagatta ctacaagact gtgtcaacgt    11820

cggcactaaa gagggcaact ggctggttaa tgcagacaga ctggtgagta gcaagacagg    11880

aaataggtat atacctggag agggtcatac ccagcaaggg aaacattatg aagaactgat    11940

attggcaagg aagccgatca gcaattttga agggactgat agatacaatt tgggcccaat    12000

agtcaacgta gtgttgagga ggctgagagt catgatgatg gctcttatag gaaggggggt    12060

gtaagcatgg ccggccctta accgggccct atcagtagaa ccctgttgta aataacacta    12120

acttattatt tatttaaata ctattattta tttatttatt tatttattga atgagcaagg    12180

attggtacaa actacctcat gttaccacac tacactcatt ttaacagcac tttagctgga    12240

gggaaaatcc tgacgtccat agttggacta aggtaatttc ctaacggccc               12290


<210>  5
<211>  12293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GD18-ddErnsHC-KARD


<220>
<221>  misc_feature
<222>  (12250)..(12250)
<223>  n is a, c, g, or t

<400>  5
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca agaccaaaat tccgatttgg       60

cctagggcac ccctccagcg acggccgaac tgggctagcc atgcccacag taggactagc      120

aaacggaggg actagccgta gtggcgagct ccctgggtgg tctaagtcct gagtacagga      180

cagtcgtcag tagttcgacg tgagcaggag cccacctcga gatgctatgt ggacgagggc      240

atgcccaaga cacaccttaa ccctggcggg ggtcgccagg gtgaaatcac accatgtgat      300

gggggtacga cctgataggg tgctgcagag gcccactaac aggctagtat aaaaaatctc      360

tgctgtacat ggcacatgga gttgaatcat tttgaactac tatacaaaac aaataaacaa      420

aaaccaatag gagtggagga accggtgtat gacatcacag gaagaccatt tttcggggac      480

ccaagtgagg tacacccaca atcaacactg aagctgccac atgacagggg gagaggtaat      540

atcagaacta cactgaagaa cctacctagg aaaggcgact gtaggagtgg aaaccaccta      600

ggaccagtca gtgggatata tgtaaaaccc ggccctgtct tctatcagga ctacatgggc      660

cctgtctatc atagagctcc attggagttt tttgaagagg cccagctgtg tgaggtgact      720

aagagaatag gtagggtgac gggtagtgat gggaagcttt accacatata tgtgtgcatt      780

gacggttgca tactgctgaa gttagccaaa aggggcacgc ctagatccct aaagtggact      840

aggaacttca ccgactgtcc actatgggtc actagttgtt ctgatgatgg cgcaggtggc      900

agcaaggata agaaaccaga caggatgaac aagggtaaat taaaaatagc cccaaaagag      960

catgagaagg acagcaaaac caagccacct gatgccacga tcgtggtaga gggagtaaaa     1020

taccaagtga aaaagaaagg caaagtcaaa gggaagaaca ctcaagatgg cctataccat     1080

aataagaaca aaccaccaga gtccaggaag aaactagaaa aagccctact ggcttgggca     1140

gtgataacaa tcgtactgta ccagcctgta gcggccgaga atataactca gtggaacctg     1200

agtgacaatg gcacaagcgg tatccagcaa gccatgtatc ttagaggggt taataggagt     1260

ctacatggga tctggcctga aaaaatatgc aaaggggtcc ctactcacct ggctactgat     1320

acggagctga cagagatacg agggatgatg gacgccagcg agaggacaaa ctatacgtgt     1380

tgcaggttgc agagacacga atggaataaa ggatggtgta actggtacaa catagacccc     1440

tggattcaat taatgaacag gacccaagca aatctgacag aaggcccccc ggataaggag     1500

tgcgccgtga cttgcaggta tgacaaaaat gctgacgtta acgtggtcac ccaggccagg     1560

aatagaccaa ccactctgac cggctgcaag aaaggaaaaa acttttcatt tgcaggtacg     1620

attatagagg gcccatgcaa tttcaacgtc tccgtggagg acatcctata tggggaccat     1680

gagggcagcc tgttccagga cacagctctg tacctattag atggaatgac caacactata     1740

gagaaagcca ggcagggtgc ggcaagagtt acatcctggc ttgggaggca actcagaacc     1800

acagggaaga agttggagag aggaagcaaa acctggttcg gcgcctacgc cctgtcacct     1860

tactgtaacg taacaaggaa agtggggtac atatggtata cgaacaattg cactccggca     1920

tgtctcccaa aaaacacgaa aataataggt ccaggaaaat tcgataccaa cgcggaagat     1980

gggaagatac ttcatgaaat ggggggccac ctatcagaat ttttgttgct ttctttagta     2040

atcctgtctg acttcgcccc ggagacggcc agtacgctat acctaatctt acactatgca     2100

atccctcagt cccatgaaga gcctgagggt tgcgatacga accagctcaa tctaacagtg     2160

ggacttagga cagaagatgt ggtaccatca tcagtttgga atatcggcaa atatgtgtgt     2220

gtcagaccag actggtggcc gtatgaaact aaggtggctt tgctgtttga ggaggcagga     2280

caggttataa aactagctct acgggcactg agagatttaa ctagagtctg gaacagtgca     2340

tcaactactg cgttcctcat ctgcttgata aaaatattaa gaggacaggt tgtgcaaggt     2400

ataatatggc tgctgctggt aactggggca caagggcggt tgacctgtaa ggaagactac     2460

aggtatgcga tatcaaagac caatgagata gggccgcttg ccgctaggga cctcactacc     2520

acctggaaag aatacaacca tggtttacag ctggatgacg ggactgtcag ggccacttgc     2580

actgcagggt cctttaaagt tatagcactt aatgtggtta gtaggaggta cctggcatca     2640

ttacacaaga gggctttgcc cacctcagta acatttgaac tcctatttga tgggaccagc     2700

ccagtaattg aggagatggg agacgacttt ggatttgggc tgtgcccttt tgacacgatc     2760

cctgtggtca aagggaagta taacaccacc ttattaaacg gcagtgcttt ctatctagtc     2820

tgccctatag gatggacggg tgttatagag tgcacggcag taagccccac aaccttgaga     2880

acagaagtgg tgaagacctt caagagagag aagcctttcc ctcacagagt ggactgcgtg     2940

accactatag tagaaaaaga agacctgttc tattgcaggc tggggggtaa ttggacatgc     3000

gtgaaaggtg acccggtgac ctacacgggg ggccaagtaa aacaatgcag gtggtgcggt     3060

ttcaacttca aggagcctga tgggctccca cactacccca taggcaagtg catcctagca     3120

aatgagacgg gatacagggt agtggactcc acagactgca acagagacgg cgtcgtcatc     3180

ggcactgaag gagagcatga gtgcttgatc ggcaacacca ccgtcaaggt gcacgcgctg     3240

gacggaagac tggcccctat gccttgcaga cccaaagaaa tcgtatctag tgcgggacct     3300

gtaaggaaaa cttcctgcac atttaactat acaaagactt tgaggaacaa gtactatgag     3360

cccagggaca gctacttcca gcaatacatg cttaagggcg agtatcaata ctggtttgat     3420

ctggacgtga cagaccacca cacagactac ttcgccgagt ttgttgtctt ggtggtagtg     3480

gcactattag ggggaaggta cgtcctgtgg ctaatagtga cctatatagt tctaacagag     3540

caactcgctg ctggtttaca gctaggccag ggcgaggtgg tgctgatagg gaacttaatc     3600

acccacatgg acaacgaggt agtggtatac ttcttactgc tttacctaat aataagagac     3660

gagcccataa agaaatggat actactgctg ttccatgcca tgaccaacaa cccagttaag     3720

accatgacag tagcattgct aatgataagc ggggtagcca agggtgggaa aatagatggt     3780

ggttggcaga ggcagccgga gaccaatttt gacatccaat tcgcactggc agtcataata     3840

gtcgtcgtga tgttgttggc aaagagagat ccgactactt ttcccctggt gatcactgtg     3900

gcaaccttga gaacggctaa gataaccagt ggtttcagca cagatctagc catagccaca     3960

gtgtcggcaa ctttgctaac ctggacttat atcagtgact actacaaata caagacttgg     4020

ctacagtacc tcatcagcac ggtgactgga atttttctga taagggtact gaagggggtc     4080

ggcgagttgg acctacacgc cccgactctg ccatcccaca gacccctttt ctacatcctt     4140

gtgtacctca tctccactgc cgtggtaacg agatggaact tggacgtagc cggaatactg     4200

ctacagtgcg ccccaacact tctaatggta ttcacgatgt gggctgacat cctcacccta     4260

attctcatac tgcccaccta tgagttgaca aagttatatt accttaagga agtgaagata     4320

gggactgaaa gaggatggct gtggaaaact aattacaaga gggtaaatga catctatgaa     4380

gtcgaccaag ctggcgaagg ggtttacctc ttcccttcga aacaaaagac tggagctata     4440

acgagcaccg tgttgccgtt gatcaaagcc atactcatta gctgcatcag taacaagtgg     4500

caattcatat atttactgta cttgatattt gaggtgacct actaccttca caagaaaatc     4560

atagatgaga tagccggcgg gaccaacttc gtttcgagac tagtggcggc tttaattgaa     4620

gttaattggg ctctagacaa tgaagaagtc aaaggcctaa agaagttttt cttgttgtct     4680

agtagggtca aagagttggt tatcaaacac aaagtgagga atgaagtaat ggtccgctgg     4740

tttgaagatg aagagatcta cgggatgcca aagctgatcg gcctggttaa ggcagcaaca     4800

ctgagcaaaa acaaacactg tattttgtgc accgtctgtg aggacagaga ttggcgggga     4860

gaaacttgcc cgaaatgcgg gcgttttgga ccaccagtga tctgtggtat gaccctagct     4920

gacttcgagg aaaaacacta taagaggatt ttcatcaggg aggaccaatc agacgggccg     4980

ctcagggagg agcatgcagg gtacttgcag tacaaagcta ggggtcaatt gtttctgagg     5040

aatctcccag tgttggcaac aaaagtcaag atgcttctgg ttggcaacct agggacagag     5100

gttggggacc tggagcacct tggctgggtg ctcagagggc ccgctgtctg caagaaggtt     5160

actgaacatg aaaagtgtgc tacgtctata atggataagt tgactgcctt ctttggtgtc     5220

atgccaaggg gtaccacccc cagagctcct gtaagatttc ccacctccct tctaaagata     5280

agaagagggc tggagacggg ttgggcttat acacaccaag gcggtatcag ctcagttgac     5340

catgttactt gcgggaaaga cctgctagtg tgtgacacca tgggtcggac aagggttgtc     5400

tgccaatcga ataacaagat gactgacgag tctgaatacg gagtcaaaac cgactcaggg     5460

tgcccagagg gagccaggtg ctacgtgttc aaccctgagg cagttaatat atcaggcact     5520

aaaggagcca tggtccactt acagaaaact ggtggagaat tcacctgtgt aacagcatca     5580

gggaccccag ctttcttcga tctcaagaac ctcaagggtt ggtcagggct accgatattt     5640

gaagcatcga gtggaagggt agtcggaagg gtcaaggtcg ggaagaacga agactctaaa     5700

ccaaccaaac tcatgagtgg gatacaaacg gtctctaaaa gtgccactga tttgacggag     5760

atggtgaaga agataacaac catgaacagg ggggagttca gacaaataac cttggccaca     5820

ggtgctggaa aaactacaga gctacccagg tcagtcatag aagagatagg gagacacaaa     5880

agggtgctgg tattgatccc ccttagggcc gcagcagaat cagtatacca atacatgagg     5940

cagaaacacc cgagtatagc attcaacctg aggatagggg agatggagga aggatacatg     6000

gccacgggaa taacctatgc ttcttatggt tacttttgcc agatgccaca acccaagttg     6060

agagccgcaa tggtagagta ttcctacatc tttctagacg agtaccattg cgccaccccg     6120

gaacaattgg ctatcatggg gaagatccac agattctcag agaacctgcg ggtggtcgct     6180

atgacagcga cgccggcagg cacggtaaca actactgggc agaaacaccc tatagaggag     6240

ttcatagccc cggaagtgat gaaaggagaa gacttaggtt cagagtactt agacatcgcc     6300

ggactaaaga taccagtaga ggagatgaag aacaacatgc tagtttttgt accaactagg     6360

aacatggcag tggaggcggc aaagaaattg aaagccaaag gatataactc aggctattac     6420

tacagtggtg aggacccatc caacctgagg gtagttacat cgcagtcccc atacgtggtg     6480

gtagcgacca acgcaataga atcaggcgtc actctcccag accttgatgt ggtcgttgac     6540

acaggactca agtgtgagaa aagaatccga ctgtcaccca agatgccttt catagtgact     6600

ggcctgaaaa gaatggccgt cactattggg gaacaagccc agagaagagg gagggttgga     6660

agagtaaagc ccgggagata ctacaggagc caagaaactc cagtcggctc taaggactac     6720

cactatgact tgctgcaagc ccaaaggtac ggtatagaag atgggataaa tatcaccaaa     6780

tccttcagag agatgaacta cgattggagc ctttatgagg aagatagcct gatgataaca     6840

caactggaaa tcctcaacaa tctgttgata tcagaggagc tgccggtagc agtaaaaaat     6900

ataatggcta ggactgacca cccagaacca attcaactag cgtataatag ctacgagaca     6960

caggtaccag tgttgttccc aaagataagg aatggagagg tgactgacac ttacgacaac     7020

tacaccttcc tcaatgcaag aaaattggga gatgatgtac ccccctatgt gtatgccaca     7080

gaagatgagg acttggcagt ggaactgtta ggcctagatt ggccagaccc tggaaaccaa     7140

ggcactgtgg aggctggcag agcactaaaa caggtggtcg gcctatcaac agccgagaat     7200

gccctgctag tggccttgtt tggctacgta gggtaccagg ccctctcaaa aaggcatata     7260

cctgtagtca cagacatata ttcagttgaa gatcacaggt tggaagatac aacacaccta     7320

cagtatgccc cgaacgccat caagacggag gggaaggaga ctgaattgaa ggagttggct     7380

caaggggatg tgcagagatg tgtggaagca gtggccaatt atgcgagtga gggcatccaa     7440

tttattaagt cacaggcact gaaggtgaga gagaccccga cttacaaaga gacaatgaat     7500

acagtggcag actatgtgaa aaagttcatt gaggcactgt cagatagcaa ggaagacatc     7560

ttgaaatatg ggctgtgggg tgtacacacg gccttgtata agagcattgg tgccagacta     7620

ggtcacgaaa ctgcgttcgc aactttagtc gtgaaatggt tggcatttgg gggggaatca     7680

gtaacagatc acataaagca agcagccaca gacttggttg tttactatat tatcaacaga     7740

cctcaattcc caggggacac ggagacacaa caagaaggga ggaaatttgt ggccagctta     7800

ctggtctcag ccctagcaac ctacacatac aaaagctgga actacaacaa tctgtccaag     7860

atagttgaac ctgctttggc cactttgccc tacgccgcca aagcccttaa attattcgcc     7920

cctacccgac tggagagcgt cgtcatattg agcaccgcaa tctacaaaac atatctatca     7980

atcaggcgag gcaaaagtga tggattgctt ggtacagggg ttagtgcggc tatggagatt     8040

atgtcacaaa atccagtatc agtgggcata gcagtcatgc tgggggttgg ggctgtagca     8100

gcccataatg caattgaagc cagtgagcag aagagaacac tactaatgaa agtctttgtg     8160

aaaaacttct tggaccaagc agccacggat gaactagtca aagagagccc tgagaaaata     8220

ataatggccc tgtttgaagc agtgcagacg gtaggcaacc ctctcagact ggtgtaccac     8280

ctatatggag ttttttataa agggtgggaa gcaaaagagt tggcccaaag gacagccggc     8340

aggaacctct tcaccttaat aatgttcgag gctgtggaac tactgggagt agatagtgaa     8400

gggaaaatcc gccagctctc aagtaactac atattagagc tcctgtacaa gttccgtgac     8460

gacatcaaat ctagtgtgag ggagatagca atcagttggg cccctgcccc cttcagctgc     8520

gactggacac caacagatga cagaatagga cttccccatg acaattatct ccagatggag     8580

acaagatgtc cttgtggtta caggatgaaa gcagtaaaaa cctgtgccgg ggagttgaga     8640

ctcctggaag aggggggttc attcctctgc aggaataaat tcggcagagg gtcacggaat     8700

tatagggtga caaaatatta tgatgacaac ttatcagaaa taaaaccagt gataagaatg     8760

gaaggacacg tggaactgta tcataaaggg gccactttca aactggactt tgacaacagt     8820

aaaacagtac tggcaacaga tagatgggaa gtcgaccatt ccaccctgat cagggtgctc     8880

aagaggcaca caggggctgg atttcaaggg gcgtatctgg gtgagaaacc caatcacaag     8940

cacctgatag agagagactg tgcaacgatc acaaaagaca aggtctgctt catcaaaatg     9000

aagagggggt gcgcgttcac ctatgactta tcactccaca accttacccg gctaatcgaa     9060

ttggtacata agaacaacct ggatgacaga gaaatccctg ccgttacggt cacaacctgg     9120

ctggcctaca cattcgtgaa tgaagacata gggaccataa aaccagtctt cggggaaaaa     9180

gtaacaccgg agaagcagga ggaggtagcc ttgcagcctg cagtggtggt ggacacaaca     9240

gatgtggccg tgaccgtggt gggggaaacc tccactatga ccacagggga gacccccaca     9300

atatttacca gcttaggttc ggactctaag tttcaacaag tcctgaaact gggggtggat     9360

gagggtcaat atcccgggcc caggcagcag agagcaagtt tgctcgaagc tgtacaaggt     9420

gtagatgaga ggccctcggt actaatattg gggtctgata aggccacctc caatagggtg     9480

aagaccgcaa agaatgtgaa gatattcagg agcagagacc ccctggaact gagagagatg     9540

atgagaagag ggaagatcct aatcatagcc ctgtgtaagg tggacaccgc tctgctgaaa     9600

tttgttgatt acaaaggtac cttcctgacc agagagaccc tagaggcatt aagtctgggc     9660

aaacctaaga aaagagacat aactaagaca gaggcacgat ggttgttgtg cctcgaaggt     9720

caattagaag agctgcctga ctggtttgca gccaaggagc ccatattctt agaagccaac     9780

atcaaacgtg acaagtatca tctggtggga gacatagcta caatcaaaga aaaagccaag     9840

caactggggg caacagactc cacaaagata tcaaaagagg ttggcgcgaa agtgtattct     9900

atgaagttga gtaactgggt gatacaggaa gagaataaac agggcagctt aacccccttg     9960

tttgaagagc tcctgcaaca gtgcccgccc gggggccaga ataaaaccac acatatggcc    10020

tcagcctacc aattggctca ggggaactgg atgccagttg gttgccacgt gttcatgggg    10080

accatacccg ctagaagaac caagactcat ccctacgagg catatgtcaa gttgagggag    10140

ttggtggaag aacataagat gaagacatca tgtggcggtt caggcctatg taagcacaac    10200

gaatgggtaa ttcgtaagat caagcatcaa gggaacctga ggaccagaca catgctgaac    10260

cccggaaaga ttgctgagca actggataga gaagggcaca gacacaatgt gtacaacaag    10320

accataggct cagtaatgac agcgactggc atcaggctgg aaaagttacc cgtggttaga    10380

gcccagacag atacaactaa tttccaccaa gcaataaggg ataaaataga caaggaagag    10440

aacctacaga ccccaggctt acacaagaag ttaatggagg tattcaatgc attaaaaaga    10500

cctgagcttg aggcctctta cgacgccgtg gagtgggagg aattggagag aggaataaat    10560

aggaagggtg ctgcagggtt cttcgaacgc aagaatatag gagaggtcct agattcagaa    10620

aaatataagg ttgaagagat catagacagt ttgaagaaag gtaggagtat taaatattat    10680

gaaactgcaa tcccaaagaa cgaaaagagg gatgtcaatg atgactggac tgccggagac    10740

tttgtggatg agaaaaaacc cagggtgata caatatcctg aggccaaaac caggttagcc    10800

atcactaaag tgatgtataa gtgggtgaaa cagaaaccag tagtcatacc cggctatgaa    10860

ggtaagacac ctctgttcca aatttttgac aaagtgaaaa aagaatggaa ccaattccaa    10920

aatccagtgg cagtgagctt tgacactaaa gcatgggata cccaggtgac tacaagagac    10980

ctggaactaa taagggatat acagaagttc tatttcaaga agaagtggca caaattcatc    11040

gacaccctaa ccatgcacat gtcagaagta cccgtgatta gtgccgacgg ggaggtgtat    11100

ataaggaaag ggcagagagg cagtgggcaa cctgatacga gcgcaggcaa cagtatgctg    11160

aatgtgttaa caatggttta tgccttctgt gaggccacgg gggtacccta taaaagtttc    11220

gacagagtgg caaagatcca cgtctgtggg gatgatggct tcttgattac tgaaagggct    11280

cttggtgaaa aatttgcaag tagaggagtc cagatcctat atgaagccgg gaagccccaa    11340

aaaatcactg aaggggacaa tatgaaagtg gcctatcagt ttgacgacat cgagttctgc    11400

tcccatacac cagtgcaggt aaggtggtca gacaacacct ccagttacat gccggggagg    11460

aacacaacca caatactggc aaaaatggct acaaggttgg attccagtgg tgagagaggc    11520

actatagcat atgagaaggc agtggcattc agtttcttgt tgatgtactc ctggaaccca    11580

ctgattagaa ggatatgctt attggtgtta tcaactgaaa tgcaagtgag accagggaag    11640

tcaaccacct attactatga aggagaccca atatctgctt acaaggaggt catcggccat    11700

aatctctttg accttaaaag aacaagtttc gagaagctag ctaagctaaa tcttagtatg    11760

tccacactcg gggtatggac caggcatacc agcaaaagat tactacaaga ctgtgtcaat    11820

gtcggcacca aagagggcaa ctggctggtt aacgcagaca gactggtgag tagtaagaca    11880

gggaataggt atatacctgg agagggtcat acccaacaag gaaaacatta tgaagagctg    11940

gtattggcaa gaaaaccgac cagtaatttt gaagggactg atagatataa tttgggccca    12000

atagtcaacg tagtgttgag gaggctgaga gtcatgatga tggctcttat aggaaggggg    12060

gtgtgagagc ggccggctct tgaccgggcc ctatcagtat aaccctgttg taaataacgc    12120

taacttatta tttatctaga cactactatt tatttattta tttatttatt gaatgagcaa    12180

ggaatggtac gaactacctc atgttaccac actacactca ttttaacagc actttagctg    12240

aggaaaaaan tcctgacgtc catagttgga ctaaggtaat ttcctaacgg ccc           12293


<210>  6
<211>  11804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GD18-ddNproErnsH-KARD


<220>
<221>  misc_feature
<222>  (11761)..(11761)
<223>  n is a, c, g, or t

<400>  6
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca agaccaaaat tccgatttgg       60

cctagggcac ccctccagcg acggccgaac tgggctagcc atgcccacag taggactagc      120

aaacggaggg actagccgta gtggcgagct ccctgggtgg tctaagtcct gagtacagga      180

cagtcgtcag tagttcgacg tgagcaggag cccacctcga gatgctatgt ggacgagggc      240

atgcccaaga cacaccttaa ccctggcggg ggtcgccagg gtgaaatcac accatgtgat      300

gggggtacga cctgataggg tgctgcagag gcccactaac aggctagtat aaaaaatctc      360

tgctgtacat ggcacatgga gttgaattct gatgatggcg caggtggcag caaggataag      420

aaaccagaca ggatgaacaa gggtaaatta aaaatagccc caaaagagca tgagaaggac      480

agcaaaacca agccacctga tgccacgatc gtggtagagg gagtaaaata ccaagtgaaa      540

aagaaaggca aagtcaaagg gaagaacact caagatggcc tataccataa taagaacaaa      600

ccaccagagt ccaggaagaa actagaaaaa gccctactgg cttgggcagt gataacaatc      660

gtactgtacc agcctgtagc ggccgagaat ataactcagt ggaacctgag tgacaatggc      720

acaagcggta tccagcaagc catgtatctt agaggggtta ataggagtct acatgggatc      780

tggcctgaaa aaatatgcaa aggggtccct actcacctgg ctactgatac ggagctgaca      840

gagatacgag ggatgatgga cgccagcgag aggacaaact atacgtgttg caggttgcag      900

agacacgaat ggaataaagg atggtgtaac tggtacaaca tagacccctg gattcaatta      960

atgaacagga cccaagcaaa tctgacagaa ggccccccgg ataaggagtg cgccgtgact     1020

tgcaggtatg acaaaaatgc tgacgttaac gtggtcaccc aggccaggaa tagaccaacc     1080

actctgaccg gctgcaagaa aggaaaaaac ttttcatttg caggtacgat tatagagggc     1140

ccatgcaatt tcaacgtctc cgtggaggac atcctatatg gggaccatga gtgtggcagc     1200

ctgttccagg acacagctct gtacctatta gatggaatga ccaacactat agagaaagcc     1260

aggcagggtg cggcaagagt tacatcctgg cttgggaggc aactcagaac cacagggaag     1320

aagttggaga gaggaagcaa aacctggttc ggcgcctacg ccctgtcacc ttactgtaac     1380

gtaacaagga aagtggggta catatggtat acgaacaatt gcactccggc atgtctccca     1440

aaaaacacga aaataatagg tccaggaaaa ttcgatacca acgcggaaga tgggaagata     1500

cttcatgaaa tggggggcca cctatcagaa tttttgttgc tttctttagt aatcctgtct     1560

gacttcgccc cggagacggc cagtacgcta tacctaatct tacactatgc aatccctcag     1620

tcccatgaag agcctgaagg ttgcgatacg aaccagctca atctaacagt gggacttagg     1680

acagaagatg tggtaccatc atcagtttgg aatatcggca aatatgtgtg tgtcagacca     1740

gactggtggc cgtatgaaac taaggtggct ttgctgtttg aggaggcagg acaggttata     1800

aaactagctc tacgggcact gagagattta actagagtct ggaacagtgc atcaactact     1860

gcgttcctca tctgcttgat aaaaatatta agaggacagg ttgtgcaagg tataatatgg     1920

ctgctgctgg taactggggc acaagggcgg ttgacctgta aggaagacta caggtatgcg     1980

atatcaaaga ccaatgagat agggccgctt gccgctaggg acctcactac cacctggaaa     2040

gaatacaacc atggtttaca gctggatgac gggactgtca gggccacttg cactgcaggg     2100

tcctttaaag ttatagcact taatgtggtt agtaggaggt acctggcatc attacacaag     2160

agggctttgc ccacctcagt aacatttgaa ctcctatttg atgggaccag cccagtaatt     2220

gaggagatgg gagacgactt tggatttggg ctgtgccctt ttgacacgat ccctgtggtc     2280

aaagggaagt ataacaccac cttattaaac ggcagtgctt tctatctagt ctgccctata     2340

ggatggacgg gtgttataga gtgcacggca gtaagcccca caaccttgag aacagaagtg     2400

gtgaagacct tcaagagaga gaagcctttc cctcacagag tggactgcgt gaccactata     2460

gtagaaaaag aagacctgtt ctattgcagg ctggggggta attggacatg cgtgaaaggt     2520

gacccggtga cctacacggg gggccaagta aaacaatgca ggtggtgcgg tttcaacttc     2580

aaggagcctg atgggctccc acactacccc ataggcaagt gcatcctagc aaatgagacg     2640

ggatacaggg tagtggactc cacagactgc aacagagacg gcgtcgtcat cggcactgaa     2700

ggagagcatg agtgcttgat cggcaacacc accgtcaagg tgcacgcgct ggacggaaga     2760

ctggccccta tgccttgcag acccaaagaa atcgtatcta gtgcgggacc tgtaaggaaa     2820

acttcctgca catttaacta tacaaagact ttgaggaaca agtactatga gcccagggac     2880

agctacttcc agcaatacat gcttaagggc gagtatcaat actggtttga tctggacgtg     2940

acagaccacc acacagacta cttcgccgag tttgttgtct tggtggtagt ggcactatta     3000

gggggaaggt acgtcctgtg gctaatagtg acctatatag ttctaacaga gcaactcgct     3060

gctggtttac agctaggcca gggcgaggtg gtgctgatag ggaacttaat cacccacatg     3120

gacaacgagg tagtggtata cttcttactg ctttacctaa taataagaga cgagcccata     3180

aagaaatgga tactactgct gttccatgcc atgaccaaca acccagttaa gaccatgaca     3240

gtagcattgc taatgataag cggggtagcc aagggtggga aaatagatgg tggttggcag     3300

aggcagccgg agaccaattt tgacatccaa ttcgcactgg cagtcataat agtcgtcgtg     3360

atgttgttgg caaagagaga tccgactact tttcccctgg tgatcactgt ggcaaccttg     3420

agaacggcta agataaccag tggtttcagc acagatctag ccatagccac agtgtcggca     3480

actttgctaa cctggactta tatcagtgac tactacaaat acaagacttg gctacagtac     3540

ctcatcagca cggtgactgg aatttttctg ataagggtac tgaagggggt cggcgagttg     3600

gacctacacg ccccgactct gccatcccac agaccccttt tctacatcct tgtgtacctc     3660

atctccactg ccgtggtaac gagatggaac ttggacgtag ccggaatact gctacagtgc     3720

gccccaacac ttctaatggt attcacgatg tgggctgaca tcctcaccct aattctcata     3780

ctgcccacct atgagttgac aaagttatat taccttaagg aagtgaagat agggactgaa     3840

agaggatggc tgtggaaaac taattacaag agggtaaatg acatctatga agtcgaccaa     3900

gctggcgaag gggtttacct cttcccttcg aaacaaaaga ctggagctat aacgagcacc     3960

gtgttgccgt tgatcaaagc catactcatt agctgcatca gtaacaagtg gcaattcata     4020

tatttactgt acttgatatt tgaggtgtcc tactaccttc acaagaaaat catagatgag     4080

atagccggcg ggaccaactt cgtttcgaga ctagtggcgg ctttaattga agttaattgg     4140

gctctagaca atgaagaagt caaaggccta aagaagtttt tcttgttgtc tagtagggtc     4200

aaagagttgg ttatcaaaca caaagtgagg aatgaagtaa tggtccgctg gtttgaagat     4260

gaagagatct acgggatgcc aaagctgatc ggcctggtta aggcagcaac actgagcaaa     4320

aacaaacact gtattttgtg caccgtctgt gaggacagag attggcgggg agaaacttgc     4380

ccgaaatgcg ggcgttttgg accaccagtg atctgtggta tgaccctagc tgacttcgag     4440

gaaaaacact ataagaggat tttcatcagg gaggaccaat cagacgggcc gctcagggag     4500

gagcatgcag ggtacttgca gtacaaagct aggggtcaat tgtttctgag gaatctccca     4560

gtgttggcaa caaaagtcaa gatgcttctg gttggcaacc tagggacaga ggttggggac     4620

ctggagcacc ttggctgggt gctcagaggg cccgctgtct gcaagaaggt tactgaacat     4680

gaaaagtgtg ctacgtctat aatggataag ttgactgcct tctttggtgt catgccaagg     4740

ggtaccaccc ccagagctcc tgtaagattt cccacctccc ttctaaagat aagaagaggg     4800

ctggagacgg gttgggctta tacacaccaa ggcggtatca gctcagttga ccatgttact     4860

tgcgggaaag acctgctagt gtgtgacacc atgggtcgga caagggttgt ctgccaatcg     4920

aataacaaga tgactgacga gtctgaatac ggagtcaaaa ccgactcagg gtgcccagag     4980

ggagccaggt gctacgtgtt caaccctgag gcagttaata tatcaggcac taaaggagcc     5040

atggtccact tacagaaaac tggtggagaa ttcacctgtg taacagcatc agggacccca     5100

gctttcttcg atctcaagaa cctcaagggt tggtcagggc taccgatatt tgaagcatcg     5160

agtggaaggg tagtcggaag ggtcaaggtc gggaagaacg aagactctaa accaaccaaa     5220

ctcatgagtg ggatacaaac ggtctctaaa agtgccactg atttgacgga gatggtgaag     5280

aagataacaa ccatgaacag gggggagttc agacaaataa ccttggccac aggtgctgga     5340

aaaactacag agctacccag gtcagtcata gaagagatag ggagacacaa aagggtgctg     5400

gtattgatcc cccttagggc cgcagcagaa tcagtatacc aatacatgag gcagaaacac     5460

ccgagtatag cattcaacct gaggataggg gagatggagg aaggatacat ggccacggga     5520

ataacctatg cttcttatgg ttacttttgc cagatgccac aacccaagtt gagagccgca     5580

atggtagagt attcctacat ctttctagac gagtaccatt gcgccacccc ggaacaattg     5640

gctatcatgg ggaagatcca cagattctca gagaacctgc gggtggtcgc tatgacagcg     5700

acgccggcag gcacggtaac aactactggg cagaaacacc ctatagagga gttcatagcc     5760

ccggaagtga tgaaaggaga agacttaggt tcagagtact tagacatcgc cggactaaag     5820

ataccagtag aggagatgaa gaacaacatg ctagtttttg taccaactag gaacatggca     5880

gtggaggcgg caaagaaatt gaaagccaaa ggatataact caggctatta ctacagtggt     5940

gaggacccat ccaacctgag ggtagttaca tcgcagtccc catacgtggt ggtagcgacc     6000

aacgcaatag aatcaggcgt cactctccca gaccttgatg tggtcgttga cacaggactc     6060

aagtgtgaga aaagaatccg actgtcaccc aagatgcctt tcatagtgac tggcctgaaa     6120

agaatggccg tcactattgg ggaacaagcc cagagaagag ggagggttgg aagagtaaag     6180

cccgggagat actacaggag ccaagaaact ccagtcggct ctaaggacta ccactatgac     6240

ttgctgcaag cccaaaggta cggtatagaa gatgggataa atatcaccaa atccttcaga     6300

gagatgaact acgattggag cctttatgag gaagatagcc tgatgataac acaactggaa     6360

atcctcaaca atctgttgat atcagaggag ctgccggtag cagtaaaaaa tataatggct     6420

aggactgacc acccagaacc aattcaacta gcgtataata gctacgagac acaggtacca     6480

gtgttgttcc caaagataag gaatggagag gtgactgaca cttacgacaa ctacaccttc     6540

ctcaatgcaa gaaaattggg agatgatgta cccccctatg tgtatgccac agaagatgag     6600

gacttggcag tggaactgtt aggcctagat tggccagacc ctggaaacca aggcactgtg     6660

gaggctggca gagcactaaa acaggtggtc ggcctatcaa cagccgagaa tgccctgcta     6720

gtggccttgt ttggctacgt agggtaccag gccctctcaa aaaggcatat acctgtagtc     6780

acagacatat attcagttga agatcacagg ttggaagata caacacacct acagtatgcc     6840

ccgaacgcca tcaagacgga ggggaaggag actgaattga aggagttggc tcaaggggat     6900

gtgcagagat gtgtggaagc agtggccaat tatgcgagtg agggcatcca atttattaag     6960

tcacaggcac tgaaggtgag agagaccccg acttacaaag agacaatgaa tacagtggca     7020

gactatgtga aaaagttcat tgaggcactg tcagatagca aggaagacat cttgaaatat     7080

gggctgtggg gtgtacacac ggccttgtat aagagcattg gtgccagact aggtcacgaa     7140

actgcgttcg caactttagt cgtgaaatgg ttggcatttg ggggggaatc agtaacagat     7200

cacataaagc aagcagccac agacttggtt gtttactata ttatcaacag acctcaattc     7260

ccaggggaca cggagacaca acaagaaggg aggaaatttg tggccagctt actggtctca     7320

gccctagcaa cctacacata caaaagctgg aactacaaca atctgtccaa gatagttgaa     7380

cctgctttgg ccactttgcc ctacgccgcc aaagccctta aattattcgc ccctacccga     7440

ctggagagcg tcgtcatatt gagcaccgca atctacaaaa catatctatc aatcaggcga     7500

ggcaaaagtg atggattgct tggtacaggg gttagtgcgg ctatggagat tatgtcacaa     7560

aatccagtat cagtgggcat agcagtcatg ctgggggttg gggctgtagc agcccataat     7620

gcaattgaag ccagtgagca gaagagaaca ctactaatga aagtctttgt gaaaaacttc     7680

ttggaccaag cagccacgga tgaactagtc aaagagagcc ctgagaaaat aataatggcc     7740

ctgtttgaag cagtgcagac ggtaggcaac cctctcagac tggtgtacca cctatatgga     7800

gttttttata aagggtggga agcaaaagag ttggcccaaa ggacagccgg caggaacctc     7860

ttcaccttaa taatgttcga ggctgtggaa ctactgggag tagatagtga agggaaaatc     7920

cgccagctct caagtaacta catattagag ctcctgtaca agttccgtga cgacatcaaa     7980

tctagtgtga gggagatagc aatcagttgg gcccctgccc ccttcagctg cgactggaca     8040

ccaacagatg acagaatagg acttccccat gacaattatc tccagatgga gacaagatgt     8100

ccttgtggtt acaggatgaa agcagtaaaa acctgtgccg gggagttgag actcctggaa     8160

gaggggggtt cattcctctg caggaataaa ttcggcagag ggtcacggaa ttatagggtg     8220

acaaaatatt atgatgacaa cttatcagaa ataaaaccag tgataagaat ggaaggacac     8280

gtggaactgt atcataaagg ggccactttc aaactggact ttgacaacag taaaacagta     8340

ctggcaacag atagatggga agtcgaccat tccaccctga tcagggtgct caagaggcac     8400

acaggggctg gatttcaagg ggcgtatctg ggtgagaaac ccaatcacaa gcacctgata     8460

gagagagact gtgcaacgat cacaaaagac aaggtctgct tcatcaaaat gaagaggggg     8520

tgcgcgttca cctatgactt atcactccac aaccttaccc ggctaatcga attggtacat     8580

aagaacaacc tggatgacag agaaatccct gccgttacgg tcacaacctg gctggcctac     8640

acattcgtga atgaagacat agggaccata aaaccagtct tcggggaaaa agtaacaccg     8700

gagaagcagg aggaggtagc cttgcagcct gcagtggtgg tggacacaac agatgtggcc     8760

gtgaccgtgg tgggggaaac ctccactatg accacagggg agacccccac aatatttacc     8820

agcttaggtt cggactctaa gtttcaacaa gtcctgaaac tgggggtgga tgagggtcaa     8880

tatcccgggc ccaggcagca gagagcaagt ttgctcgaag ctgtacaagg tgtagatgag     8940

aggccctcgg tactaatatt ggggtctgat aaggccacct ccaatagggt gaagaccgca     9000

aagaatgtga agatattcag gagcagagac cccctggaac tgagagagat gatgagaaga     9060

gggaagatcc taatcatagc cctgtgtaag gtggacaccg ctctgctgaa atttgttgat     9120

tacaaaggta ccttcctgac cagagagacc ctagaggcat taagtctggg caaacctaag     9180

aaaagagaca taactaagac agaggcacga tggttgttgt gcctcgaagg tcaattagaa     9240

gagctgcctg actggtttgc agccaaggag cccatattct tagaagccaa catcaaacgt     9300

gacaagtatc atctggtggg agacatagct acaatcaaag aaaaagccaa gcaactgggg     9360

gcaacagact ccacaaagat atcaaaagag gttggcgcga aagtgtattc tatgaagttg     9420

agtaactggg tgatacagga agagaataaa cagggcagct taaccccctt gtttgaagag     9480

ctcctgcaac agtgcccgcc cgggggccag aataaaacca cacatatggc ctcagcctac     9540

caattggctc aggggaactg gatgccagtt ggttgccacg tgttcatggg gaccataccc     9600

gctagaagaa ccaagactca tccctacgag gcatatgtca agttgaggga gttggtggaa     9660

gaacataaga tgaagacatc atgtggcggt tcaggcctat gtaagcacaa cgaatgggta     9720

attcgtaaga tcaagcatca agggaacctg aggaccagac acatgctgaa ccccggaaag     9780

attgctgagc aactggatag agaagggcac agacacaatg tgtacaacaa gaccataggc     9840

tcagtaatga cagcgactgg catcaggctg gaaaagttac ccgtggttag agcccagaca     9900

gatacaacta atttccacca agcaataagg gataaaatag acaaggaaga gaacctacag     9960

accccaggct tacacaagaa gttaatggag gtattcaatg cattaaaaag acctgagctt    10020

gaggcctctt acgacgccgt ggagtgggag gaattggaga gaggaataaa taggaagggt    10080

gctgcagggt tcttcgaacg caagaatata ggagaggtcc tagattcaga aaaatataag    10140

gttgaagaga tcatagacag tttgaagaaa ggtaggagta ttaaatatta tgaaactgca    10200

atcccaaaga acgaaaagag ggatgtcaat gatgactgga ctgccggaga ctttgtggat    10260

gagaaaaaac ccagggtgat acaatatcct gaggccaaaa ccaggttagc catcactaaa    10320

gtgatgtata agtgggtgaa acagaaacca gtagtcatac ccggctatga aggtaagaca    10380

cctctgttcc aaatttttga caaagtgaaa aaagaatgga accaattcca aaatccagtg    10440

gcagtgagct ttgacactaa agcatgggat acccaggtga ctacaagaga cctggaacta    10500

ataagggata tacagaagtt ctatttcaag aagaagtggc acaaattcat cgacacccta    10560

accatgcaca tgtcagaagt acccgtgatt agtgccgacg gggaggtgta tataaggaaa    10620

gggcagagag gcagtgggca acctgatacg agcgcaggca acagtatgct gaatgtgtta    10680

acaatggttt atgccttctg tgaggccacg ggggtaccct ataaaagttt cgacagagtg    10740

gcaaagatcc acgtctgtgg ggatgatggc ttcttgatta ctgaaagggc tcttggtgaa    10800

aaatttgcaa gtagaggagt ccagatccta tatgaagccg ggaagcccca aaaaatcact    10860

gaaggggaca atatgaaagt ggcctatcag tttgacgaca tcgagttctg ctcccataca    10920

ccagtgcagg taaggtggtc agacaacacc tccagttaca tgccggggag gaacacaacc    10980

acaatactgg caaaaatggc tacaaggttg gattccagtg gtgagagagg cactatagca    11040

tatgagaagg cagtggcatt cagtttcttg ttgatgtact cctggaaccc actgattaga    11100

aggatatgct tattggtgtt atcaactgaa atgcaagtga gaccagggaa gtcaaccacc    11160

tattactatg aaggagaccc aatatctgct tacaaggagg tcatcggcca taatctcttt    11220

gaccttaaaa gaacaagttt cgagaagcta gctaagctaa atcttagtat gtccacactc    11280

ggggtatgga ccaggcatac cagcaaaaga ttactacaag actgtgtcaa tgtcggcacc    11340

aaagagggca actggctggt taacgcagac agactggtga gtagtaagac agggaatagg    11400

tatatacctg gagagggtca tacccaacaa ggaaaacatt atgaagagct ggtattggca    11460

agaaaaccga ccagtaattt tgaagggact gatagatata atttgggccc aatagtcaac    11520

gtagtgttga ggaggctgag agtcatgatg atggctctta taggaagggg ggtgtgagag    11580

cggccggctc ttgaccgggc cctatcagta taaccctgtt gtaaataacg ctaacttatt    11640

atttatctag acactactat ttatttattt atttatttat tgaatgagca aggaatggta    11700

cgaactacct catgttacca cactacactc attttaacag cactttagct gaggaaaaaa    11760

ntcctgacgt ccatagttgg actaaggtaa tttcctaacg gccc                     11804


<210>  7
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QZ07-E2

<400>  7

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Ile Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  8
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD18-E2

<400>  8

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  9
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of heavy chain of mAb 6B8

<400>  9

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Asp Ser Phe Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asp Leu Pro Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala 
    130                 135 


<210>  10
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of light chain of mAb 6B8

<400>  10

Met Gly Ile Lys Met Glu Thr His Ser Gln Val Phe Val Tyr Met Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His 
            20                  25                  30          


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
        35                  40                  45              


Ala Ser Gln Ala Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            100                 105                 110         


His Gln Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B8 epitope for GD18 or QZ07 or GD191

<400>  11

Ser Thr Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B8 epitope for C strain

<400>  12

Ser Thr Asp Glu Ile Gly Leu Leu Gly Ala Gly Gly 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KRD for GD18 or QZ07 or GD191

<400>  13

Lys Thr Asn Glu Ile Gly Pro Leu Gly Ala Arg Asp 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KARD for GD18 or QZ07 or GD191

<400>  14

Lys Thr Asn Glu Ile Gly Pro Leu Ala Ala Arg Asp 
1               5                   10          


<210>  15
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Npro of GD18

<400>  15

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Ile Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Phe 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asn Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Glu Glu Ala Gln Leu Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys 
                165             


<210>  16
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Erns of GD18

<400>  16

Glu Asn Ile Thr Gln Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile 
1               5                   10                  15      


Gln Gln Ala Met Tyr Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile 
            20                  25                  30          


Trp Pro Glu Lys Ile Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp 
        35                  40                  45              


Thr Glu Leu Thr Glu Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr 
    50                  55                  60                  


Asn Tyr Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His Gly 
65                  70                  75                  80  


Trp Cys Asn Trp Tyr Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg 
                85                  90                  95      


Thr Gln Ala Asn Leu Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val 
            100                 105                 110         


Thr Cys Arg Tyr Asp Lys Asn Ala Asp Val Asn Val Val Thr Gln Ala 
        115                 120                 125             


Arg Asn Arg Pro Thr Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe 
    130                 135                 140                 


Ser Phe Ala Gly Thr Ile Ile Glu Gly Pro Cys Asn Phe Asn Val Ser 
145                 150                 155                 160 


Val Glu Asp Ile Leu Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln 
                165                 170                 175     


Asp Thr Ala Leu Tyr Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys 
            180                 185                 190         


Ala Arg Gln Gly Ala Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu 
        195                 200                 205             


Ser Thr Thr Gly Lys Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly 
    210                 215                 220                 


Ala Tyr Ala 
225         


<210>  17
<211>  3898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of GD18

<400>  17

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Ile Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Phe 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asn Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Glu Glu Ala Gln Leu Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Ala Gly Gly Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Thr Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys His Gly Trp Cys Asn Trp Tyr 
            340                 345                 350         


Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu 
        355                 360                 365             


Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp 
    370                 375                 380                 


Lys Asn Ala Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr 
385                 390                 395                 400 


Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr 
                405                 410                 415     


Ile Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu 
            420                 425                 430         


Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr 
        435                 440                 445             


Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala 
    450                 455                 460                 


Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Ser Thr Thr Gly Lys 
465                 470                 475                 480 


Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser 
                485                 490                 495     


Pro Tyr Cys Asn Val Thr Arg Lys Val Gly Tyr Ile Trp Tyr Thr Asn 
            500                 505                 510         


Asn Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro 
        515                 520                 525             


Gly Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met 
    530                 535                 540                 


Gly Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Ile Leu Ser 
545                 550                 555                 560 


Asp Phe Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr 
                565                 570                 575     


Ala Ile Pro Gln Ser His Glu Glu Pro Glu Gly Cys Asp Thr Asn Gln 
            580                 585                 590         


Leu Asn Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser 
        595                 600                 605             


Val Trp Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro 
    610                 615                 620                 


Tyr Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile 
625                 630                 635                 640 


Lys Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser 
                645                 650                 655     


Ala Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly 
            660                 665                 670         


Gln Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln 
        675                 680                 685             


Gly Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr 
    690                 695                 700                 


Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys 
705                 710                 715                 720 


Glu Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr 
                725                 730                 735     


Cys Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg 
            740                 745                 750         


Arg Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr 
        755                 760                 765             


Phe Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly 
    770                 775                 780                 


Asp Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val 
785                 790                 795                 800 


Lys Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu 
                805                 810                 815     


Val Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser 
            820                 825                 830         


Pro Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys 
        835                 840                 845             


Pro Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu 
    850                 855                 860                 


Asp Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly 
865                 870                 875                 880 


Asp Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys 
                885                 890                 895     


Gly Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly 
            900                 905                 910         


Lys Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr 
        915                 920                 925             


Asp Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu 
    930                 935                 940                 


Cys Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg 
945                 950                 955                 960 


Leu Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly 
                965                 970                 975     


Pro Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg 
            980                 985                 990         


Asn Lys Tyr Tyr Glu Pro Arg Asp  Ser Tyr Phe Gln Gln  Tyr Met Leu 
        995                 1000                 1005             


Lys Gly  Glu Tyr Gln Tyr Trp  Phe Asp Leu Asp Val  Thr Asp His 
    1010                 1015                 1020             


His Thr  Asp Tyr Phe Ala Glu  Phe Val Val Leu Val  Val Val Ala 
    1025                 1030                 1035             


Leu Leu  Gly Gly Arg Tyr Val  Leu Trp Leu Ile Val  Thr Tyr Ile 
    1040                 1045                 1050             


Val Leu  Thr Glu Gln Leu Ala  Ala Gly Leu Gln Leu  Gly Gln Gly 
    1055                 1060                 1065             


Glu Val  Val Leu Ile Gly Asn  Leu Ile Thr His Met  Asp Asn Glu 
    1070                 1075                 1080             


Val Val  Val Tyr Phe Leu Leu  Leu Tyr Leu Ile Ile  Arg Asp Glu 
    1085                 1090                 1095             


Pro Ile  Lys Lys Trp Ile Leu  Leu Leu Phe His Ala  Met Thr Asn 
    1100                 1105                 1110             


Asn Pro  Val Lys Thr Met Thr  Val Ala Leu Leu Met  Ile Ser Gly 
    1115                 1120                 1125             


Val Ala  Lys Gly Gly Lys Ile  Asp Gly Gly Trp Gln  Arg Gln Pro 
    1130                 1135                 1140             


Glu Thr  Asn Phe Asp Ile Gln  Phe Ala Leu Ala Val  Ile Ile Val 
    1145                 1150                 1155             


Val Val  Met Leu Leu Ala Lys  Arg Asp Pro Thr Thr  Phe Pro Leu 
    1160                 1165                 1170             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Ser Gly 
    1175                 1180                 1185             


Phe Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Ala  Thr Leu Leu 
    1190                 1195                 1200             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Trp Leu 
    1205                 1210                 1215             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1220                 1225                 1230             


Leu Lys  Gly Val Gly Glu Leu  Asp Leu His Ala Pro  Thr Leu Pro 
    1235                 1240                 1245             


Ser His  Arg Pro Leu Phe Tyr  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1250                 1255                 1260             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Val Ala Gly  Ile Leu Leu 
    1265                 1270                 1275             


Gln Cys  Ala Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1280                 1285                 1290             


Ile Leu  Thr Leu Ile Leu Ile  Leu Pro Thr Tyr Glu  Leu Thr Lys 
    1295                 1300                 1305             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Thr Glu  Arg Gly Trp 
    1310                 1315                 1320             


Leu Trp  Lys Thr Asn Tyr Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1325                 1330                 1335             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1340                 1345                 1350             


Thr Gly  Ala Ile Thr Ser Thr  Val Leu Pro Leu Ile  Lys Ala Ile 
    1355                 1360                 1365             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Phe Ile  Tyr Leu Leu 
    1370                 1375                 1380             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Ile Ile 
    1385                 1390                 1395             


Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Val Ser Arg  Leu Val Ala 
    1400                 1405                 1410             


Ala Leu  Ile Glu Val Asn Trp  Ala Leu Asp Asn Glu  Glu Val Lys 
    1415                 1420                 1425             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1430                 1435                 1440             


Val Ile  Lys His Lys Val Arg  Asn Glu Val Met Val  Arg Trp Phe 
    1445                 1450                 1455             


Glu Asp  Glu Glu Ile Tyr Gly  Met Pro Lys Leu Ile  Gly Leu Val 
    1460                 1465                 1470             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1475                 1480                 1485             


Val Cys  Glu Asp Arg Asp Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1490                 1495                 1500             


Gly Arg  Phe Gly Pro Pro Val  Ile Cys Gly Met Thr  Leu Ala Asp 
    1505                 1510                 1515             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Ile Arg  Glu Asp Gln 
    1520                 1525                 1530             


Ser Asp  Gly Pro Leu Arg Glu  Glu His Ala Gly Tyr  Leu Gln Tyr 
    1535                 1540                 1545             


Lys Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1550                 1555                 1560             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1565                 1570                 1575             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1580                 1585                 1590             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Ala Thr  Ser Ile Met 
    1595                 1600                 1605             


Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1610                 1615                 1620             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1625                 1630                 1635             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1640                 1645                 1650             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1655                 1660                 1665             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1685                 1690                 1695             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1700                 1705                 1710             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1715                 1720                 1725             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1730                 1735                 1740             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1745                 1750                 1755             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1760                 1765                 1770             


Glu Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1775                 1780                 1785             


Ser Lys  Ser Ala Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1790                 1795                 1800             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1805                 1810                 1815             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1820                 1825                 1830             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1835                 1840                 1845             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1850                 1855                 1860             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Glu Glu Gly  Tyr Met Ala 
    1865                 1870                 1875             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1880                 1885                 1890             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Tyr Ile Phe 
    1895                 1900                 1905             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1910                 1915                 1920             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1925                 1930                 1935             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1940                 1945                 1950             


Pro Ile  Glu Glu Phe Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1955                 1960                 1965             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1970                 1975                 1980             


Glu Glu  Met Lys Asn Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1985                 1990                 1995             


Met Ala  Val Glu Ala Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    2000                 2005                 2010             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    2015                 2020                 2025             


Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    2030                 2035                 2040             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    2045                 2050                 2055             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    2060                 2065                 2070             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    2075                 2080                 2085             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    2090                 2095                 2100             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    2105                 2110                 2115             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    2120                 2125                 2130             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    2135                 2140                 2145             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    2150                 2155                 2160             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Val Ala Val  Lys Asn Ile 
    2165                 2170                 2175             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2180                 2185                 2190             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Arg Asn 
    2195                 2200                 2205             


Gly Glu  Val Thr Asp Thr Tyr  Asp Asn Tyr Thr Phe  Leu Asn Ala 
    2210                 2215                 2220             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2225                 2230                 2235             


Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2240                 2245                 2250             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2255                 2260                 2265             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2270                 2275                 2280             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2285                 2290                 2295             


Val Val  Thr Asp Ile Tyr Ser  Val Glu Asp His Arg  Leu Glu Asp 
    2300                 2305                 2310             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2315                 2320                 2325             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2330                 2335                 2340             


Cys Val  Glu Ala Val Ala Asn  Tyr Ala Ser Glu Gly  Ile Gln Phe 
    2345                 2350                 2355             


Ile Lys  Ser Gln Ala Leu Lys  Val Arg Glu Thr Pro  Thr Tyr Lys 
    2360                 2365                 2370             


Glu Thr  Met Asn Thr Val Ala  Asp Tyr Val Lys Lys  Phe Ile Glu 
    2375                 2380                 2385             


Ala Leu  Ser Asp Ser Lys Glu  Asp Ile Leu Lys Tyr  Gly Leu Trp 
    2390                 2395                 2400             


Gly Val  His Thr Ala Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2405                 2410                 2415             


His Glu  Thr Ala Phe Ala Thr  Leu Val Val Lys Trp  Leu Ala Phe 
    2420                 2425                 2430             


Gly Gly  Glu Ser Val Thr Asp  His Ile Lys Gln Ala  Ala Thr Asp 
    2435                 2440                 2445             


Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2450                 2455                 2460             


Thr Glu  Thr Gln Gln Glu Gly  Arg Lys Phe Val Ala  Ser Leu Leu 
    2465                 2470                 2475             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2480                 2485                 2490             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2495                 2500                 2505             


Ala Ala  Lys Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2510                 2515                 2520             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2525                 2530                 2535             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2540                 2545                 2550             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Val  Gly Ile Ala 
    2555                 2560                 2565             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2570                 2575                 2580             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2585                 2590                 2595             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2600                 2605                 2610             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2615                 2620                 2625             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2630                 2635                 2640             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2645                 2650                 2655             


Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2660                 2665                 2670             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2675                 2680                 2685             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Asp Ile Lys  Ser Ser Val 
    2690                 2695                 2700             


Arg Glu  Ile Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2705                 2710                 2715             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro His  Asp Asn Tyr 
    2720                 2725                 2730             


Leu Gln  Met Glu Thr Arg Cys  Pro Cys Gly Tyr Arg  Met Lys Ala 
    2735                 2740                 2745             


Val Lys  Thr Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Gly Gly 
    2750                 2755                 2760             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2765                 2770                 2775             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2780                 2785                 2790             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr His  Lys Gly Ala 
    2795                 2800                 2805             


Thr Phe  Lys Leu Asp Phe Asp  Asn Ser Lys Thr Val  Leu Ala Thr 
    2810                 2815                 2820             


Asp Arg  Trp Glu Val Asp His  Ser Thr Leu Ile Arg  Val Leu Lys 
    2825                 2830                 2835             


Arg His  Thr Gly Ala Gly Phe  Gln Gly Ala Tyr Leu  Gly Glu Lys 
    2840                 2845                 2850             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2855                 2860                 2865             


Lys Asp  Lys Val Cys Phe Ile  Lys Met Lys Arg Gly  Cys Ala Phe 
    2870                 2875                 2880             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2885                 2890                 2895             


Val His  Lys Asn Asn Leu Asp  Asp Arg Glu Ile Pro  Ala Val Thr 
    2900                 2905                 2910             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2915                 2920                 2925             


Thr Ile  Lys Pro Val Phe Gly  Glu Lys Val Thr Pro  Glu Lys Gln 
    2930                 2935                 2940             


Glu Glu  Val Ala Leu Gln Pro  Ala Val Val Val Asp  Thr Thr Asp 
    2945                 2950                 2955             


Val Ala  Val Thr Val Val Gly  Glu Thr Ser Thr Met  Thr Thr Gly 
    2960                 2965                 2970             


Glu Thr  Pro Thr Ile Phe Thr  Ser Leu Gly Ser Asp  Ser Lys Phe 
    2975                 2980                 2985             


Gln Gln  Val Leu Lys Leu Gly  Val Asp Glu Gly Gln  Tyr Pro Gly 
    2990                 2995                 3000             


Pro Arg  Gln Gln Arg Ala Ser  Leu Leu Glu Ala Val  Gln Gly Val 
    3005                 3010                 3015             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    3020                 3025                 3030             


Ser Asn  Arg Val Lys Thr Ala  Lys Asn Val Lys Ile  Phe Arg Ser 
    3035                 3040                 3045             


Arg Asp  Pro Leu Glu Leu Arg  Glu Met Met Arg Arg  Gly Lys Ile 
    3050                 3055                 3060             


Leu Ile  Ile Ala Leu Cys Lys  Val Asp Thr Ala Leu  Leu Lys Phe 
    3065                 3070                 3075             


Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    3080                 3085                 3090             


Leu Ser  Leu Gly Lys Pro Lys  Lys Arg Asp Ile Thr  Lys Thr Glu 
    3095                 3100                 3105             


Ala Arg  Trp Leu Leu Cys Leu  Glu Gly Gln Leu Glu  Glu Leu Pro 
    3110                 3115                 3120             


Asp Trp  Phe Ala Ala Lys Glu  Pro Ile Phe Leu Glu  Ala Asn Ile 
    3125                 3130                 3135             


Lys Arg  Asp Lys Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    3140                 3145                 3150             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    3155                 3160                 3165             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  Ser Asn Trp 
    3170                 3175                 3180             


Val Ile  Gln Glu Glu Asn Lys  Gln Gly Ser Leu Thr  Pro Leu Phe 
    3185                 3190                 3195             


Glu Glu  Leu Leu Gln Gln Cys  Pro Pro Gly Gly Gln  Asn Lys Thr 
    3200                 3205                 3210             


Thr His  Met Ala Ser Ala Tyr  Gln Leu Ala Gln Gly  Asn Trp Met 
    3215                 3220                 3225             


Pro Val  Gly Cys His Val Phe  Met Gly Thr Ile Pro  Ala Arg Arg 
    3230                 3235                 3240             


Thr Lys  Thr His Pro Tyr Glu  Ala Tyr Val Lys Leu  Arg Glu Leu 
    3245                 3250                 3255             


Val Glu  Glu His Lys Met Lys  Thr Ser Cys Gly Gly  Ser Gly Leu 
    3260                 3265                 3270             


Cys Lys  His Asn Glu Trp Val  Ile Arg Lys Ile Lys  His Gln Gly 
    3275                 3280                 3285             


Asn Leu  Arg Thr Arg His Met  Leu Asn Pro Gly Lys  Ile Ala Glu 
    3290                 3295                 3300             


Gln Leu  Asp Arg Glu Gly His  Arg His Asn Val Tyr  Asn Lys Thr 
    3305                 3310                 3315             


Ile Gly  Ser Val Met Thr Ala  Thr Gly Ile Arg Leu  Glu Lys Leu 
    3320                 3325                 3330             


Pro Val  Val Arg Ala Gln Thr  Asp Thr Thr Asn Phe  His Gln Ala 
    3335                 3340                 3345             


Ile Arg  Asp Lys Ile Asp Lys  Glu Glu Asn Leu Gln  Thr Pro Gly 
    3350                 3355                 3360             


Leu His  Lys Lys Leu Met Glu  Val Phe Asn Ala Leu  Lys Arg Pro 
    3365                 3370                 3375             


Glu Leu  Glu Ala Ser Tyr Asp  Ala Val Glu Trp Glu  Glu Leu Glu 
    3380                 3385                 3390             


Arg Gly  Ile Asn Arg Lys Gly  Ala Ala Gly Phe Phe  Glu Arg Lys 
    3395                 3400                 3405             


Asn Ile  Gly Glu Val Leu Asp  Ser Glu Lys Tyr Lys  Val Glu Glu 
    3410                 3415                 3420             


Ile Ile  Asp Ser Leu Lys Lys  Gly Arg Ser Ile Lys  Tyr Tyr Glu 
    3425                 3430                 3435             


Thr Ala  Ile Pro Lys Asn Glu  Lys Arg Asp Val Asn  Asp Asp Trp 
    3440                 3445                 3450             


Thr Ala  Gly Asp Phe Val Asp  Glu Lys Lys Pro Arg  Val Ile Gln 
    3455                 3460                 3465             


Tyr Pro  Glu Ala Lys Thr Arg  Leu Ala Ile Thr Lys  Val Met Tyr 
    3470                 3475                 3480             


Lys Trp  Val Lys Gln Lys Pro  Val Val Ile Pro Gly  Tyr Glu Gly 
    3485                 3490                 3495             


Lys Thr  Pro Leu Phe Gln Ile  Phe Asp Lys Val Lys  Lys Glu Trp 
    3500                 3505                 3510             


Asn Gln  Phe Gln Asn Pro Val  Ala Val Ser Phe Asp  Thr Lys Ala 
    3515                 3520                 3525             


Trp Asp  Thr Gln Val Thr Thr  Arg Asp Leu Glu Leu  Ile Arg Asp 
    3530                 3535                 3540             


Ile Gln  Lys Phe Tyr Phe Lys  Lys Lys Trp His Lys  Phe Ile Asp 
    3545                 3550                 3555             


Thr Leu  Thr Met His Met Ser  Glu Val Pro Val Ile  Ser Ala Asp 
    3560                 3565                 3570             


Gly Glu  Val Tyr Ile Arg Lys  Gly Gln Arg Gly Ser  Gly Gln Pro 
    3575                 3580                 3585             


Asp Thr  Ser Ala Gly Asn Ser  Met Leu Asn Val Leu  Thr Met Val 
    3590                 3595                 3600             


Tyr Ala  Phe Cys Glu Ala Thr  Gly Val Pro Tyr Lys  Ser Phe Asp 
    3605                 3610                 3615             


Arg Val  Ala Lys Ile His Val  Cys Gly Asp Asp Gly  Phe Leu Ile 
    3620                 3625                 3630             


Thr Glu  Arg Ala Leu Gly Glu  Lys Phe Ala Ser Arg  Gly Val Gln 
    3635                 3640                 3645             


Ile Leu  Tyr Glu Ala Gly Lys  Pro Gln Lys Ile Thr  Glu Gly Asp 
    3650                 3655                 3660             


Asn Met  Lys Val Ala Tyr Gln  Phe Asp Asp Ile Glu  Phe Cys Ser 
    3665                 3670                 3675             


His Thr  Pro Val Gln Val Arg  Trp Ser Asp Asn Thr  Ser Ser Tyr 
    3680                 3685                 3690             


Met Pro  Gly Arg Asn Thr Thr  Thr Ile Leu Ala Lys  Met Ala Thr 
    3695                 3700                 3705             


Arg Leu  Asp Ser Ser Gly Glu  Arg Gly Thr Ile Ala  Tyr Glu Lys 
    3710                 3715                 3720             


Ala Val  Ala Phe Ser Phe Leu  Leu Met Tyr Ser Trp  Asn Pro Leu 
    3725                 3730                 3735             


Ile Arg  Arg Ile Cys Leu Leu  Val Leu Ser Thr Glu  Met Gln Val 
    3740                 3745                 3750             


Arg Pro  Gly Lys Ser Thr Thr  Tyr Tyr Tyr Glu Gly  Asp Pro Ile 
    3755                 3760                 3765             


Ser Ala  Tyr Lys Glu Val Ile  Gly His Asn Leu Phe  Asp Leu Lys 
    3770                 3775                 3780             


Arg Thr  Ser Phe Glu Lys Leu  Ala Lys Leu Asn Leu  Ser Met Ser 
    3785                 3790                 3795             


Thr Leu  Gly Val Trp Thr Arg  His Thr Ser Lys Arg  Leu Leu Gln 
    3800                 3805                 3810             


Asp Cys  Val Asn Val Gly Thr  Lys Glu Gly Asn Trp  Leu Val Asn 
    3815                 3820                 3825             


Ala Asp  Arg Leu Val Ser Ser  Lys Thr Gly Asn Arg  Tyr Ile Pro 
    3830                 3835                 3840             


Gly Glu  Gly His Thr Gln Gln  Gly Lys His Tyr Glu  Glu Leu Val 
    3845                 3850                 3855             


Leu Ala  Arg Lys Pro Thr Ser  Asn Phe Glu Gly Thr  Asp Arg Tyr 
    3860                 3865                 3870             


Asn Leu  Gly Pro Ile Val Asn  Val Val Leu Arg Arg  Leu Arg Val 
    3875                 3880                 3885             


Met Met  Met Ala Leu Ile Gly  Arg Gly Val 
    3890                 3895             


<210>  18
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Npro of QZ07

<400>  18

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Gly Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Ala Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys 
                165             


<210>  19
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Erns of QZ07

<400>  19

Glu Asn Ile Thr Gln Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile 
1               5                   10                  15      


Gln Gln Ala Met Tyr Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile 
            20                  25                  30          


Trp Pro Glu Lys Ile Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp 
        35                  40                  45              


Thr Glu Leu Thr Glu Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr 
    50                  55                  60                  


Asn Tyr Thr Cys Cys Arg Leu Gln Arg His Glu Trp Asn Lys His Gly 
65                  70                  75                  80  


Trp Cys Asn Trp Tyr Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg 
                85                  90                  95      


Thr Gln Ala Asn Leu Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val 
            100                 105                 110         


Thr Cys Arg Tyr Asp Lys Asn Thr Asp Val Asn Val Val Thr Gln Ala 
        115                 120                 125             


Arg Asn Arg Pro Thr Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe 
    130                 135                 140                 


Ser Phe Ala Gly Thr Val Ile Glu Gly Pro Cys Asn Phe Asn Val Ser 
145                 150                 155                 160 


Val Glu Asp Ile Leu Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln 
                165                 170                 175     


Asp Thr Ala Leu Tyr Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys 
            180                 185                 190         


Ala Arg Gln Gly Ala Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu 
        195                 200                 205             


Arg Thr Thr Gly Lys Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly 
    210                 215                 220                 


Ala Tyr Ala 
225         


<210>  20
<211>  3898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of QZ07

<400>  20

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Gly Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Ala Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Thr Gly Asp Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Ala Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys His Gly Trp Cys Asn Trp Tyr 
            340                 345                 350         


Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu 
        355                 360                 365             


Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp 
    370                 375                 380                 


Lys Asn Thr Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr 
385                 390                 395                 400 


Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr 
                405                 410                 415     


Val Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu 
            420                 425                 430         


Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr 
        435                 440                 445             


Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala 
    450                 455                 460                 


Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys 
465                 470                 475                 480 


Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser 
                485                 490                 495     


Pro Tyr Cys Asn Val Thr Arg Lys Ile Gly Tyr Ile Trp Tyr Thr Asn 
            500                 505                 510         


Asn Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro 
        515                 520                 525             


Gly Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met 
    530                 535                 540                 


Gly Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Val Leu Ser 
545                 550                 555                 560 


Asp Phe Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr 
                565                 570                 575     


Ala Ile Pro Gln Ser Arg Asp Glu Pro Glu Val Cys Asp Thr Asn Gln 
            580                 585                 590         


Leu Asn Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser 
        595                 600                 605             


Val Trp Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro 
    610                 615                 620                 


Tyr Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile 
625                 630                 635                 640 


Lys Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser 
                645                 650                 655     


Ala Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly 
            660                 665                 670         


Gln Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln 
        675                 680                 685             


Gly Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr 
    690                 695                 700                 


Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys 
705                 710                 715                 720 


Glu Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile 
                725                 730                 735     


Cys Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg 
            740                 745                 750         


Arg Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr 
        755                 760                 765             


Phe Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly 
    770                 775                 780                 


Asp Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val 
785                 790                 795                 800 


Lys Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu 
                805                 810                 815     


Val Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser 
            820                 825                 830         


Pro Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys 
        835                 840                 845             


Pro Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu 
    850                 855                 860                 


Asp Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly 
865                 870                 875                 880 


Asn Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys 
                885                 890                 895     


Gly Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly 
            900                 905                 910         


Lys Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr 
        915                 920                 925             


Asp Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu 
    930                 935                 940                 


Cys Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg 
945                 950                 955                 960 


Leu Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly 
                965                 970                 975     


Pro Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg 
            980                 985                 990         


Asn Lys Tyr Tyr Glu Pro Arg Asp  Ser Tyr Phe Gln Gln  Tyr Met Leu 
        995                 1000                 1005             


Lys Gly  Glu Tyr Gln Tyr Trp  Phe Asp Leu Asp Val  Thr Asp His 
    1010                 1015                 1020             


His Thr  Asp Tyr Phe Ala Glu  Phe Val Val Leu Val  Val Val Ala 
    1025                 1030                 1035             


Leu Leu  Gly Gly Arg Tyr Val  Leu Trp Leu Ile Val  Thr Tyr Val 
    1040                 1045                 1050             


Ile Leu  Thr Glu Gln Leu Ala  Ala Gly Leu Gln Leu  Gly Gln Gly 
    1055                 1060                 1065             


Glu Val  Val Leu Ile Gly Asn  Leu Ile Thr His Thr  Asp Asn Glu 
    1070                 1075                 1080             


Val Val  Val Tyr Phe Leu Leu  Leu Tyr Leu Ile Ile  Arg Asp Glu 
    1085                 1090                 1095             


Pro Ile  Lys Lys Trp Ile Leu  Leu Leu Phe His Ala  Met Thr Asn 
    1100                 1105                 1110             


Asn Pro  Val Lys Thr Met Thr  Val Ala Leu Leu Met  Ile Ser Gly 
    1115                 1120                 1125             


Val Ala  Lys Gly Gly Lys Thr  Asp Gly Gly Trp Gln  Arg Gln Pro 
    1130                 1135                 1140             


Glu Thr  Asn Phe Asp Ile Gln  Leu Ala Leu Ala Val  Ile Val Val 
    1145                 1150                 1155             


Val Val  Met Leu Leu Ala Lys  Arg Asp Pro Thr Thr  Phe Pro Leu 
    1160                 1165                 1170             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Asn Gly 
    1175                 1180                 1185             


Phe Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Ala  Ala Leu Leu 
    1190                 1195                 1200             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Trp Leu 
    1205                 1210                 1215             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1220                 1225                 1230             


Leu Lys  Gly Ile Gly Glu Leu  Asp Met His Ala Pro  Thr Leu Pro 
    1235                 1240                 1245             


Ser His  Arg Pro Leu Phe Tyr  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1250                 1255                 1260             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Val Ala Gly  Leu Leu Leu 
    1265                 1270                 1275             


Gln Cys  Val Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1280                 1285                 1290             


Ile Leu  Thr Leu Ile Leu Val  Leu Pro Thr Tyr Glu  Leu Ala Lys 
    1295                 1300                 1305             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Thr Glu  Arg Gly Trp 
    1310                 1315                 1320             


Leu Trp  Lys Thr Asn Tyr Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1325                 1330                 1335             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1340                 1345                 1350             


Thr Ser  Ala Ile Thr Ser Thr  Met Leu Pro Leu Ile  Lys Ala Ile 
    1355                 1360                 1365             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Leu Ile  Tyr Leu Leu 
    1370                 1375                 1380             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Val Ile 
    1385                 1390                 1395             


Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Val Ser Arg  Leu Val Ala 
    1400                 1405                 1410             


Ala Leu  Ile Glu Val Asn Trp  Ala Phe Asp Asn Glu  Glu Val Lys 
    1415                 1420                 1425             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1430                 1435                 1440             


Val Ile  Lys His Lys Val Arg  Asn Glu Val Val Ala  Arg Trp Phe 
    1445                 1450                 1455             


Gly Asp  Glu Glu Ile Tyr Gly  Met Pro Lys Leu Ile  Gly Leu Val 
    1460                 1465                 1470             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1475                 1480                 1485             


Val Cys  Glu Asp Arg Asp Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1490                 1495                 1500             


Gly Arg  Phe Gly Pro Pro Val  Ile Cys Gly Met Thr  Leu Ala Asp 
    1505                 1510                 1515             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Ile Arg  Glu Asp Gln 
    1520                 1525                 1530             


Ser Asp  Gly Pro Leu Arg Glu  Glu Arg Ala Gly Tyr  Leu Gln Tyr 
    1535                 1540                 1545             


Arg Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1550                 1555                 1560             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1565                 1570                 1575             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1580                 1585                 1590             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Ala Thr  Ser Ile Met 
    1595                 1600                 1605             


Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1610                 1615                 1620             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1625                 1630                 1635             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1640                 1645                 1650             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1655                 1660                 1665             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1685                 1690                 1695             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1700                 1705                 1710             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1715                 1720                 1725             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1730                 1735                 1740             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1745                 1750                 1755             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1760                 1765                 1770             


Asp Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1775                 1780                 1785             


Ser Lys  Ser Ala Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1790                 1795                 1800             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1805                 1810                 1815             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1820                 1825                 1830             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1835                 1840                 1845             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1850                 1855                 1860             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Lys Glu Gly  His Met Ala 
    1865                 1870                 1875             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1880                 1885                 1890             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Tyr Ile Phe 
    1895                 1900                 1905             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1910                 1915                 1920             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1925                 1930                 1935             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1940                 1945                 1950             


Pro Ile  Glu Glu Phe Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1955                 1960                 1965             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1970                 1975                 1980             


Glu Glu  Met Lys Asn Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1985                 1990                 1995             


Met Ala  Val Glu Ala Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    2000                 2005                 2010             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    2015                 2020                 2025             


Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    2030                 2035                 2040             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    2045                 2050                 2055             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    2060                 2065                 2070             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    2075                 2080                 2085             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    2090                 2095                 2100             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    2105                 2110                 2115             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    2120                 2125                 2130             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    2135                 2140                 2145             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    2150                 2155                 2160             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Val Ala Val  Lys Asn Ile 
    2165                 2170                 2175             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2180                 2185                 2190             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Arg Asn 
    2195                 2200                 2205             


Gly Glu  Val Thr Asp Thr Tyr  Asp Thr Tyr Thr Phe  Ile Asn Ala 
    2210                 2215                 2220             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2225                 2230                 2235             


Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2240                 2245                 2250             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2255                 2260                 2265             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2270                 2275                 2280             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2285                 2290                 2295             


Val Val  Thr Asp Ile Tyr Ser  Val Glu Asp His Arg  Leu Glu Asp 
    2300                 2305                 2310             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2315                 2320                 2325             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2330                 2335                 2340             


Cys Val  Glu Ala Met Thr Asn  Tyr Ala Arg Gly Gly  Ile Gln Phe 
    2345                 2350                 2355             


Met Lys  Ser Gln Ala Leu Gln  Val Arg Glu Thr Pro  Thr Tyr Lys 
    2360                 2365                 2370             


Glu Thr  Met Asn Thr Val Ala  Asp Tyr Val Lys Lys  Phe Ile Glu 
    2375                 2380                 2385             


Ala Leu  Ser Asp Ser Lys Glu  Asp Ile Leu Lys Tyr  Gly Leu Trp 
    2390                 2395                 2400             


Gly Val  His Thr Ala Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2405                 2410                 2415             


His Glu  Thr Ala Phe Ala Thr  Leu Ala Val Lys Trp  Leu Ala Phe 
    2420                 2425                 2430             


Gly Gly  Glu Ser Ile Ala Asp  His Ile Lys Gln Ala  Ala Thr Asp 
    2435                 2440                 2445             


Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2450                 2455                 2460             


Thr Glu  Thr Gln Gln Glu Gly  Arg Asn Phe Val Ala  Ser Leu Leu 
    2465                 2470                 2475             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2480                 2485                 2490             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2495                 2500                 2505             


Ala Ala  Lys Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2510                 2515                 2520             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2525                 2530                 2535             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2540                 2545                 2550             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Val  Gly Ile Ala 
    2555                 2560                 2565             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2570                 2575                 2580             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2585                 2590                 2595             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2600                 2605                 2610             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2615                 2620                 2625             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2630                 2635                 2640             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2645                 2650                 2655             


Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2660                 2665                 2670             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2675                 2680                 2685             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Ser Ile Lys  Ser Ser Val 
    2690                 2695                 2700             


Arg Glu  Ile Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2705                 2710                 2715             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro His  Asn Asn Tyr 
    2720                 2725                 2730             


Leu Gln  Met Glu Thr Arg Cys  Pro Cys Gly Tyr Arg  Met Lys Ala 
    2735                 2740                 2745             


Val Lys  Thr Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Gly Gly 
    2750                 2755                 2760             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2765                 2770                 2775             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2780                 2785                 2790             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr Tyr  Lys Gly Ala 
    2795                 2800                 2805             


Thr Ile  Lys Leu Asp Phe Asn  Asn Ser Lys Thr Val  Leu Ala Thr 
    2810                 2815                 2820             


Asp Lys  Trp Glu Val Asp His  Ser Thr Leu Val Arg  Ala Leu Lys 
    2825                 2830                 2835             


Arg His  Thr Gly Ala Gly Tyr  Gln Gly Ala Tyr Met  Gly Glu Lys 
    2840                 2845                 2850             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2855                 2860                 2865             


Lys Asp  Lys Val Tyr Phe Ile  Lys Met Lys Arg Gly  Cys Ala Phe 
    2870                 2875                 2880             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2885                 2890                 2895             


Val His  Lys Asn Asp Leu Glu  Asp Arg Glu Ile Pro  Ala Val Thr 
    2900                 2905                 2910             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2915                 2920                 2925             


Thr Ile  Lys Pro Val Phe Gly  Glu Lys Val Thr Pro  Glu Lys Gln 
    2930                 2935                 2940             


Glu Glu  Val Ala Leu Gln Pro  Ala Val Val Val Asp  Thr Thr Asp 
    2945                 2950                 2955             


Val Ala  Val Thr Val Val Gly  Glu Thr Ser Thr Met  Thr Thr Gly 
    2960                 2965                 2970             


Glu Thr  Pro Thr Ala Phe Thr  Ser Leu Gly Ser Asp  Ser Lys Val 
    2975                 2980                 2985             


Gln Gln  Val Leu Lys Leu Gly  Val Asp Glu Gly Gln  Tyr Pro Gly 
    2990                 2995                 3000             


Pro Ser  Gln Gln Arg Ala Ser  Leu Leu Asp Ala Ile  Gln Gly Val 
    3005                 3010                 3015             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    3020                 3025                 3030             


Ser Asn  Arg Val Lys Thr Ala  Lys Asn Val Lys Ile  Phe Arg Ser 
    3035                 3040                 3045             


Arg Asp  Pro Leu Glu Leu Arg  Glu Met Met Arg Arg  Gly Lys Ile 
    3050                 3055                 3060             


Leu Val  Ile Ala Leu Cys Lys  Val Asp Thr Ala Leu  Leu Lys Phe 
    3065                 3070                 3075             


Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    3080                 3085                 3090             


Leu Ser  Leu Gly Lys Pro Lys  Lys Lys Asn Ile Thr  Lys Thr Glu 
    3095                 3100                 3105             


Ala Gln  Trp Leu Leu Cys Leu  Glu Asn Gln Ile Glu  Glu Leu Pro 
    3110                 3115                 3120             


Asp Trp  Phe Ala Ala Glu Glu  Pro Val Phe Leu Glu  Ala Asn Ile 
    3125                 3130                 3135             


Lys Arg  Asp Lys Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    3140                 3145                 3150             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    3155                 3160                 3165             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  Ser Asn Trp 
    3170                 3175                 3180             


Val Ile  Gln Glu Glu Asn Lys  Gln Gly Ser Leu Ala  Pro Leu Phe 
    3185                 3190                 3195             


Glu Glu  Leu Leu Gln Gln Cys  Pro Pro Gly Gly Gln  Asn Lys Thr 
    3200                 3205                 3210             


Thr His  Met Val Ser Ala Tyr  Gln Leu Ala Gln Gly  Asn Trp Met 
    3215                 3220                 3225             


Pro Val  Gly Cys His Val Phe  Met Gly Thr Ile Pro  Ala Arg Arg 
    3230                 3235                 3240             


Thr Lys  Thr His Pro Tyr Glu  Ala Tyr Val Lys Leu  Arg Glu Leu 
    3245                 3250                 3255             


Val Asp  Glu Tyr Lys Met Lys  Thr Leu Cys Gly Gly  Ser Gly Leu 
    3260                 3265                 3270             


Ser Lys  His Asn Glu Trp Val  Ile Arg Lys Ile Lys  His Gln Gly 
    3275                 3280                 3285             


Asn Leu  Arg Thr Lys His Met  Leu Asn Pro Gly Lys  Val Ala Glu 
    3290                 3295                 3300             


Gln Leu  Leu Arg Glu Gly His  Arg His Asn Val Tyr  Asn Lys Thr 
    3305                 3310                 3315             


Ile Gly  Ser Val Met Thr Ala  Thr Gly Ile Arg Leu  Glu Lys Leu 
    3320                 3325                 3330             


Pro Val  Val Arg Ala Gln Thr  Asp Thr Thr Asn Phe  His Gln Ala 
    3335                 3340                 3345             


Ile Arg  Asp Lys Ile Asp Lys  Glu Glu Asn Leu Gln  Thr Pro Gly 
    3350                 3355                 3360             


Leu His  Lys Lys Leu Met Glu  Val Phe Asn Ala Leu  Lys Arg Pro 
    3365                 3370                 3375             


Asp Leu  Glu Ala Ser Tyr Asp  Ala Val Glu Trp Glu  Glu Leu Glu 
    3380                 3385                 3390             


Lys Gly  Ile Asn Arg Lys Gly  Ala Ala Gly Phe Phe  Glu His Lys 
    3395                 3400                 3405             


Asn Ile  Gly Glu Val Leu Asp  Ser Glu Lys Asn Lys  Val Glu Glu 
    3410                 3415                 3420             


Ile Ile  Asp Ser Leu Arg Lys  Gly Arg Ser Ile Arg  Tyr Tyr Glu 
    3425                 3430                 3435             


Thr Ala  Ile Pro Lys Asn Glu  Lys Arg Asp Val Asn  Asp Asp Trp 
    3440                 3445                 3450             


Thr Ala  Gly Asp Phe Val Asp  Glu Lys Lys Pro Arg  Val Ile Gln 
    3455                 3460                 3465             


Tyr Pro  Glu Ala Lys Thr Arg  Leu Ala Ile Thr Lys  Val Met Tyr 
    3470                 3475                 3480             


Lys Trp  Val Lys Gln Lys Pro  Val Val Ile Pro Gly  Tyr Glu Gly 
    3485                 3490                 3495             


Lys Thr  Pro Leu Phe Gln Ile  Phe Asp Lys Val Lys  Lys Glu Trp 
    3500                 3505                 3510             


Asp Gln  Phe Gln Asn Pro Val  Ala Val Ser Phe Asp  Thr Lys Ala 
    3515                 3520                 3525             


Trp Asp  Thr Gln Val Thr Thr  Gly Asp Leu Glu Leu  Ile Arg Asp 
    3530                 3535                 3540             


Ile Gln  Lys Phe Tyr Phe Lys  Lys Lys Trp His Lys  Phe Ile Asp 
    3545                 3550                 3555             


Thr Leu  Thr Met His Met Ser  Glu Val Pro Val Ile  Ser Ala Asp 
    3560                 3565                 3570             


Gly Glu  Val Tyr Ile Arg Lys  Gly Gln Arg Gly Ser  Gly Gln Pro 
    3575                 3580                 3585             


Asp Thr  Ser Ala Gly Asn Ser  Met Leu Asn Val Leu  Thr Met Val 
    3590                 3595                 3600             


Tyr Ala  Phe Cys Glu Ala Thr  Gly Val Pro Tyr Lys  Ser Phe Asp 
    3605                 3610                 3615             


Arg Val  Ala Lys Ile His Val  Cys Gly Asp Asp Gly  Phe Leu Ile 
    3620                 3625                 3630             


Thr Glu  Arg Ala Leu Gly Glu  Lys Phe Ser Ser Lys  Gly Val Gln 
    3635                 3640                 3645             


Ile Leu  Tyr Glu Ala Gly Lys  Pro Gln Lys Ile Thr  Glu Gly Asp 
    3650                 3655                 3660             


Lys Met  Lys Val Ala Tyr Gln  Phe Asp Asp Ile Glu  Phe Cys Ser 
    3665                 3670                 3675             


His Thr  Pro Val Gln Val Arg  Trp Ser Asp Asn Thr  Ser Ser Tyr 
    3680                 3685                 3690             


Met Pro  Gly Arg Asn Thr Thr  Thr Ile Leu Ala Lys  Met Ala Thr 
    3695                 3700                 3705             


Arg Leu  Asp Ser Ser Gly Glu  Arg Gly Thr Ile Ala  Tyr Glu Lys 
    3710                 3715                 3720             


Ala Val  Ala Phe Ser Phe Leu  Leu Met Tyr Ser Trp  Asn Pro Leu 
    3725                 3730                 3735             


Ile Arg  Arg Ile Cys Leu Leu  Val Leu Ser Thr Glu  Leu Gln Val 
    3740                 3745                 3750             


Arg Pro  Gly Lys Ser Thr Thr  Tyr Tyr Tyr Glu Gly  Asp Pro Ile 
    3755                 3760                 3765             


Ser Ala  Tyr Lys Glu Val Ile  Gly His Asn Leu Phe  Asp Leu Lys 
    3770                 3775                 3780             


Arg Thr  Ser Phe Glu Lys Leu  Ala Lys Leu Asn Leu  Ser Met Ser 
    3785                 3790                 3795             


Thr Leu  Gly Val Trp Thr Arg  His Thr Ser Lys Arg  Leu Leu Gln 
    3800                 3805                 3810             


Asp Cys  Val Asn Val Gly Thr  Lys Glu Gly Asn Trp  Leu Val Asn 
    3815                 3820                 3825             


Ala Asp  Arg Leu Val Ser Ser  Lys Thr Gly Asn Arg  Tyr Ile Pro 
    3830                 3835                 3840             


Gly Glu  Gly His Thr Gln Gln  Gly Lys His Tyr Glu  Glu Leu Ile 
    3845                 3850                 3855             


Leu Ala  Arg Lys Pro Ile Ser  Asn Phe Glu Gly Thr  Asp Arg Tyr 
    3860                 3865                 3870             


Asn Leu  Gly Pro Ile Val Asn  Val Val Leu Arg Arg  Leu Arg Val 
    3875                 3880                 3885             


Met Met  Met Ala Leu Ile Gly  Arg Gly Val 
    3890                 3895             


<210>  21
<211>  3897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of QZ07-sdErnsH-KARD

<400>  21

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Gly Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Ala Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Thr Gly Asp Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Ala Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys Gly Trp Cys Asn Trp Tyr Asn 
            340                 345                 350         


Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu Thr 
        355                 360                 365             


Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp Lys 
    370                 375                 380                 


Asn Thr Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr Thr 
385                 390                 395                 400 


Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr Val 
                405                 410                 415     


Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu Tyr 
            420                 425                 430         


Gly Asp His Glu Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr Leu 
        435                 440                 445             


Leu Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala Ala 
    450                 455                 460                 


Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys Lys 
465                 470                 475                 480 


Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser Pro 
                485                 490                 495     


Tyr Cys Asn Val Thr Arg Lys Ile Gly Tyr Ile Trp Tyr Thr Asn Asn 
            500                 505                 510         


Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro Gly 
        515                 520                 525             


Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met Gly 
    530                 535                 540                 


Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Val Leu Ser Asp 
545                 550                 555                 560 


Phe Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr Ala 
                565                 570                 575     


Ile Pro Gln Ser Arg Asp Glu Pro Glu Val Cys Asp Thr Asn Gln Leu 
            580                 585                 590         


Asn Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser Val 
        595                 600                 605             


Trp Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro Tyr 
    610                 615                 620                 


Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile Lys 
625                 630                 635                 640 


Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser Ala 
                645                 650                 655     


Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly Gln 
            660                 665                 670         


Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln Gly 
        675                 680                 685             


Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
    690                 695                 700                 


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
705                 710                 715                 720 


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
                725                 730                 735     


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
            740                 745                 750         


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
        755                 760                 765             


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
    770                 775                 780                 


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
785                 790                 795                 800 


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
                805                 810                 815     


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
            820                 825                 830         


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
        835                 840                 845             


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
    850                 855                 860                 


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
865                 870                 875                 880 


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
                885                 890                 895     


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
            900                 905                 910         


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
        915                 920                 925             


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
    930                 935                 940                 


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
945                 950                 955                 960 


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
                965                 970                 975     


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
            980                 985                 990         


Lys Tyr Tyr Glu Pro Arg Asp Ser  Tyr Phe Gln Gln Tyr  Met Leu Lys 
        995                 1000                 1005             


Gly Glu  Tyr Gln Tyr Trp Phe  Asp Leu Asp Val Thr  Asp His His 
    1010                 1015                 1020             


Thr Asp  Tyr Phe Ala Glu Phe  Val Val Leu Val Val  Val Ala Leu 
    1025                 1030                 1035             


Leu Gly  Gly Arg Tyr Val Leu  Trp Leu Ile Val Thr  Tyr Val Ile 
    1040                 1045                 1050             


Leu Thr  Glu Gln Leu Ala Ala  Gly Leu Gln Leu Gly  Gln Gly Glu 
    1055                 1060                 1065             


Val Val  Leu Ile Gly Asn Leu  Ile Thr His Thr Asp  Asn Glu Val 
    1070                 1075                 1080             


Val Val  Tyr Phe Leu Leu Leu  Tyr Leu Ile Ile Arg  Asp Glu Pro 
    1085                 1090                 1095             


Ile Lys  Lys Trp Ile Leu Leu  Leu Phe His Ala Met  Thr Asn Asn 
    1100                 1105                 1110             


Pro Val  Lys Thr Met Thr Val  Ala Leu Leu Met Ile  Ser Gly Val 
    1115                 1120                 1125             


Ala Lys  Gly Gly Lys Thr Asp  Gly Gly Trp Gln Arg  Gln Pro Glu 
    1130                 1135                 1140             


Thr Asn  Phe Asp Ile Gln Leu  Ala Leu Ala Val Ile  Val Val Val 
    1145                 1150                 1155             


Val Met  Leu Leu Ala Lys Arg  Asp Pro Thr Thr Phe  Pro Leu Val 
    1160                 1165                 1170             


Ile Thr  Val Ala Thr Leu Arg  Thr Ala Lys Ile Thr  Asn Gly Phe 
    1175                 1180                 1185             


Ser Thr  Asp Leu Ala Ile Ala  Thr Val Ser Ala Ala  Leu Leu Thr 
    1190                 1195                 1200             


Trp Thr  Tyr Ile Ser Asp Tyr  Tyr Lys Tyr Lys Thr  Trp Leu Gln 
    1205                 1210                 1215             


Tyr Leu  Ile Ser Thr Val Thr  Gly Ile Phe Leu Ile  Arg Val Leu 
    1220                 1225                 1230             


Lys Gly  Ile Gly Glu Leu Asp  Met His Ala Pro Thr  Leu Pro Ser 
    1235                 1240                 1245             


His Arg  Pro Leu Phe Tyr Ile  Leu Val Tyr Leu Ile  Ser Thr Ala 
    1250                 1255                 1260             


Val Val  Thr Arg Trp Asn Leu  Asp Val Ala Gly Leu  Leu Leu Gln 
    1265                 1270                 1275             


Cys Val  Pro Thr Leu Leu Met  Val Phe Thr Met Trp  Ala Asp Ile 
    1280                 1285                 1290             


Leu Thr  Leu Ile Leu Val Leu  Pro Thr Tyr Glu Leu  Ala Lys Leu 
    1295                 1300                 1305             


Tyr Tyr  Leu Lys Glu Val Lys  Ile Gly Thr Glu Arg  Gly Trp Leu 
    1310                 1315                 1320             


Trp Lys  Thr Asn Tyr Lys Arg  Val Asn Asp Ile Tyr  Glu Val Asp 
    1325                 1330                 1335             


Gln Ala  Gly Glu Gly Val Tyr  Leu Phe Pro Ser Lys  Gln Lys Thr 
    1340                 1345                 1350             


Ser Ala  Ile Thr Ser Thr Met  Leu Pro Leu Ile Lys  Ala Ile Leu 
    1355                 1360                 1365             


Ile Ser  Cys Ile Ser Asn Lys  Trp Gln Leu Ile Tyr  Leu Leu Tyr 
    1370                 1375                 1380             


Leu Ile  Phe Glu Val Ser Tyr  Tyr Leu His Lys Lys  Val Ile Asp 
    1385                 1390                 1395             


Glu Ile  Ala Gly Gly Thr Asn  Phe Val Ser Arg Leu  Val Ala Ala 
    1400                 1405                 1410             


Leu Ile  Glu Val Asn Trp Ala  Phe Asp Asn Glu Glu  Val Lys Gly 
    1415                 1420                 1425             


Leu Lys  Lys Phe Phe Leu Leu  Ser Ser Arg Val Lys  Glu Leu Val 
    1430                 1435                 1440             


Ile Lys  His Lys Val Arg Asn  Glu Val Val Ala Arg  Trp Phe Gly 
    1445                 1450                 1455             


Asp Glu  Glu Ile Tyr Gly Met  Pro Lys Leu Ile Gly  Leu Val Lys 
    1460                 1465                 1470             


Ala Ala  Thr Leu Ser Lys Asn  Lys His Cys Ile Leu  Cys Thr Val 
    1475                 1480                 1485             


Cys Glu  Asp Arg Asp Trp Arg  Gly Glu Thr Cys Pro  Lys Cys Gly 
    1490                 1495                 1500             


Arg Phe  Gly Pro Pro Val Ile  Cys Gly Met Thr Leu  Ala Asp Phe 
    1505                 1510                 1515             


Glu Glu  Lys His Tyr Lys Arg  Ile Phe Ile Arg Glu  Asp Gln Ser 
    1520                 1525                 1530             


Asp Gly  Pro Leu Arg Glu Glu  Arg Ala Gly Tyr Leu  Gln Tyr Arg 
    1535                 1540                 1545             


Ala Arg  Gly Gln Leu Phe Leu  Arg Asn Leu Pro Val  Leu Ala Thr 
    1550                 1555                 1560             


Lys Val  Lys Met Leu Leu Val  Gly Asn Leu Gly Thr  Glu Val Gly 
    1565                 1570                 1575             


Asp Leu  Glu His Leu Gly Trp  Val Leu Arg Gly Pro  Ala Val Cys 
    1580                 1585                 1590             


Lys Lys  Val Thr Glu His Glu  Lys Cys Ala Thr Ser  Ile Met Asp 
    1595                 1600                 1605             


Lys Leu  Thr Ala Phe Phe Gly  Val Met Pro Arg Gly  Thr Thr Pro 
    1610                 1615                 1620             


Arg Ala  Pro Val Arg Phe Pro  Thr Ser Leu Leu Lys  Ile Arg Arg 
    1625                 1630                 1635             


Gly Leu  Glu Thr Gly Trp Ala  Tyr Thr His Gln Gly  Gly Ile Ser 
    1640                 1645                 1650             


Ser Val  Asp His Val Thr Cys  Gly Lys Asp Leu Leu  Val Cys Asp 
    1655                 1660                 1665             


Thr Met  Gly Arg Thr Arg Val  Val Cys Gln Ser Asn  Asn Lys Met 
    1670                 1675                 1680             


Thr Asp  Glu Ser Glu Tyr Gly  Val Lys Thr Asp Ser  Gly Cys Pro 
    1685                 1690                 1695             


Glu Gly  Ala Arg Cys Tyr Val  Phe Asn Pro Glu Ala  Val Asn Ile 
    1700                 1705                 1710             


Ser Gly  Thr Lys Gly Ala Met  Val His Leu Gln Lys  Thr Gly Gly 
    1715                 1720                 1725             


Glu Phe  Thr Cys Val Thr Ala  Ser Gly Thr Pro Ala  Phe Phe Asp 
    1730                 1735                 1740             


Leu Lys  Asn Leu Lys Gly Trp  Ser Gly Leu Pro Ile  Phe Glu Ala 
    1745                 1750                 1755             


Ser Ser  Gly Arg Val Val Gly  Arg Val Lys Val Gly  Lys Asn Asp 
    1760                 1765                 1770             


Asp Ser  Lys Pro Thr Lys Leu  Met Ser Gly Ile Gln  Thr Val Ser 
    1775                 1780                 1785             


Lys Ser  Ala Thr Asp Leu Thr  Glu Met Val Lys Lys  Ile Thr Thr 
    1790                 1795                 1800             


Met Asn  Arg Gly Glu Phe Arg  Gln Ile Thr Leu Ala  Thr Gly Ala 
    1805                 1810                 1815             


Gly Lys  Thr Thr Glu Leu Pro  Arg Ser Val Ile Glu  Glu Ile Gly 
    1820                 1825                 1830             


Arg His  Lys Arg Val Leu Val  Leu Ile Pro Leu Arg  Ala Ala Ala 
    1835                 1840                 1845             


Glu Ser  Val Tyr Gln Tyr Met  Arg Gln Lys His Pro  Ser Ile Ala 
    1850                 1855                 1860             


Phe Asn  Leu Arg Ile Gly Glu  Met Lys Glu Gly His  Met Ala Thr 
    1865                 1870                 1875             


Gly Ile  Thr Tyr Ala Ser Tyr  Gly Tyr Phe Cys Gln  Met Pro Gln 
    1880                 1885                 1890             


Pro Lys  Leu Arg Ala Ala Met  Val Glu Tyr Ser Tyr  Ile Phe Leu 
    1895                 1900                 1905             


Asp Glu  Tyr His Cys Ala Thr  Pro Glu Gln Leu Ala  Ile Met Gly 
    1910                 1915                 1920             


Lys Ile  His Arg Phe Ser Glu  Asn Leu Arg Val Val  Ala Met Thr 
    1925                 1930                 1935             


Ala Thr  Pro Ala Gly Thr Val  Thr Thr Thr Gly Gln  Lys His Pro 
    1940                 1945                 1950             


Ile Glu  Glu Phe Ile Ala Pro  Glu Val Met Lys Gly  Glu Asp Leu 
    1955                 1960                 1965             


Gly Ser  Glu Tyr Leu Asp Ile  Ala Gly Leu Lys Ile  Pro Val Glu 
    1970                 1975                 1980             


Glu Met  Lys Asn Asn Met Leu  Val Phe Val Pro Thr  Arg Asn Met 
    1985                 1990                 1995             


Ala Val  Glu Ala Ala Lys Lys  Leu Lys Ala Lys Gly  Tyr Asn Ser 
    2000                 2005                 2010             


Gly Tyr  Tyr Tyr Ser Gly Glu  Asp Pro Ser Asn Leu  Arg Val Val 
    2015                 2020                 2025             


Thr Ser  Gln Ser Pro Tyr Val  Val Val Ala Thr Asn  Ala Ile Glu 
    2030                 2035                 2040             


Ser Gly  Val Thr Leu Pro Asp  Leu Asp Val Val Val  Asp Thr Gly 
    2045                 2050                 2055             


Leu Lys  Cys Glu Lys Arg Ile  Arg Leu Ser Pro Lys  Met Pro Phe 
    2060                 2065                 2070             


Ile Val  Thr Gly Leu Lys Arg  Met Ala Val Thr Ile  Gly Glu Gln 
    2075                 2080                 2085             


Ala Gln  Arg Arg Gly Arg Val  Gly Arg Val Lys Pro  Gly Arg Tyr 
    2090                 2095                 2100             


Tyr Arg  Ser Gln Glu Thr Pro  Val Gly Ser Lys Asp  Tyr His Tyr 
    2105                 2110                 2115             


Asp Leu  Leu Gln Ala Gln Arg  Tyr Gly Ile Glu Asp  Gly Ile Asn 
    2120                 2125                 2130             


Ile Thr  Lys Ser Phe Arg Glu  Met Asn Tyr Asp Trp  Ser Leu Tyr 
    2135                 2140                 2145             


Glu Glu  Asp Ser Leu Met Ile  Thr Gln Leu Glu Ile  Leu Asn Asn 
    2150                 2155                 2160             


Leu Leu  Ile Ser Glu Glu Leu  Pro Val Ala Val Lys  Asn Ile Met 
    2165                 2170                 2175             


Ala Arg  Thr Asp His Pro Glu  Pro Ile Gln Leu Ala  Tyr Asn Ser 
    2180                 2185                 2190             


Tyr Glu  Thr Gln Val Pro Val  Leu Phe Pro Lys Ile  Arg Asn Gly 
    2195                 2200                 2205             


Glu Val  Thr Asp Thr Tyr Asp  Thr Tyr Thr Phe Ile  Asn Ala Arg 
    2210                 2215                 2220             


Lys Leu  Gly Asp Asp Val Pro  Pro Tyr Val Tyr Ala  Thr Glu Asp 
    2225                 2230                 2235             


Glu Asp  Leu Ala Val Glu Leu  Leu Gly Leu Asp Trp  Pro Asp Pro 
    2240                 2245                 2250             


Gly Asn  Gln Gly Thr Val Glu  Ala Gly Arg Ala Leu  Lys Gln Val 
    2255                 2260                 2265             


Val Gly  Leu Ser Thr Ala Glu  Asn Ala Leu Leu Val  Ala Leu Phe 
    2270                 2275                 2280             


Gly Tyr  Val Gly Tyr Gln Ala  Leu Ser Lys Arg His  Ile Pro Val 
    2285                 2290                 2295             


Val Thr  Asp Ile Tyr Ser Val  Glu Asp His Arg Leu  Glu Asp Thr 
    2300                 2305                 2310             


Thr His  Leu Gln Tyr Ala Pro  Asn Ala Ile Lys Thr  Glu Gly Lys 
    2315                 2320                 2325             


Glu Thr  Glu Leu Lys Glu Leu  Ala Gln Gly Asp Val  Gln Arg Cys 
    2330                 2335                 2340             


Val Glu  Ala Met Thr Asn Tyr  Ala Arg Gly Gly Ile  Gln Phe Met 
    2345                 2350                 2355             


Lys Ser  Gln Ala Leu Gln Val  Arg Glu Thr Pro Thr  Tyr Lys Glu 
    2360                 2365                 2370             


Thr Met  Asn Thr Val Ala Asp  Tyr Val Lys Lys Phe  Ile Glu Ala 
    2375                 2380                 2385             


Leu Ser  Asp Ser Lys Glu Asp  Ile Leu Lys Tyr Gly  Leu Trp Gly 
    2390                 2395                 2400             


Val His  Thr Ala Leu Tyr Lys  Ser Ile Gly Ala Arg  Leu Gly His 
    2405                 2410                 2415             


Glu Thr  Ala Phe Ala Thr Leu  Ala Val Lys Trp Leu  Ala Phe Gly 
    2420                 2425                 2430             


Gly Glu  Ser Ile Ala Asp His  Ile Lys Gln Ala Ala  Thr Asp Leu 
    2435                 2440                 2445             


Val Val  Tyr Tyr Ile Ile Asn  Arg Pro Gln Phe Pro  Gly Asp Thr 
    2450                 2455                 2460             


Glu Thr  Gln Gln Glu Gly Arg  Asn Phe Val Ala Ser  Leu Leu Val 
    2465                 2470                 2475             


Ser Ala  Leu Ala Thr Tyr Thr  Tyr Lys Ser Trp Asn  Tyr Asn Asn 
    2480                 2485                 2490             


Leu Ser  Lys Ile Val Glu Pro  Ala Leu Ala Thr Leu  Pro Tyr Ala 
    2495                 2500                 2505             


Ala Lys  Ala Leu Lys Leu Phe  Ala Pro Thr Arg Leu  Glu Ser Val 
    2510                 2515                 2520             


Val Ile  Leu Ser Thr Ala Ile  Tyr Lys Thr Tyr Leu  Ser Ile Arg 
    2525                 2530                 2535             


Arg Gly  Lys Ser Asp Gly Leu  Leu Gly Thr Gly Val  Ser Ala Ala 
    2540                 2545                 2550             


Met Glu  Ile Met Ser Gln Asn  Pro Val Ser Val Gly  Ile Ala Val 
    2555                 2560                 2565             


Met Leu  Gly Val Gly Ala Val  Ala Ala His Asn Ala  Ile Glu Ala 
    2570                 2575                 2580             


Ser Glu  Gln Lys Arg Thr Leu  Leu Met Lys Val Phe  Val Lys Asn 
    2585                 2590                 2595             


Phe Leu  Asp Gln Ala Ala Thr  Asp Glu Leu Val Lys  Glu Ser Pro 
    2600                 2605                 2610             


Glu Lys  Ile Ile Met Ala Leu  Phe Glu Ala Val Gln  Thr Val Gly 
    2615                 2620                 2625             


Asn Pro  Leu Arg Leu Val Tyr  His Leu Tyr Gly Val  Phe Tyr Lys 
    2630                 2635                 2640             


Gly Trp  Glu Ala Lys Glu Leu  Ala Gln Arg Thr Ala  Gly Arg Asn 
    2645                 2650                 2655             


Leu Phe  Thr Leu Ile Met Phe  Glu Ala Val Glu Leu  Leu Gly Val 
    2660                 2665                 2670             


Asp Ser  Glu Gly Lys Ile Arg  Gln Leu Ser Ser Asn  Tyr Ile Leu 
    2675                 2680                 2685             


Glu Leu  Leu Tyr Lys Phe Arg  Asp Ser Ile Lys Ser  Ser Val Arg 
    2690                 2695                 2700             


Glu Ile  Ala Ile Ser Trp Ala  Pro Ala Pro Phe Ser  Cys Asp Trp 
    2705                 2710                 2715             


Thr Pro  Thr Asp Asp Arg Ile  Gly Leu Pro His Asn  Asn Tyr Leu 
    2720                 2725                 2730             


Gln Met  Glu Thr Arg Cys Pro  Cys Gly Tyr Arg Met  Lys Ala Val 
    2735                 2740                 2745             


Lys Thr  Cys Ala Gly Glu Leu  Arg Leu Leu Glu Glu  Gly Gly Ser 
    2750                 2755                 2760             


Phe Leu  Cys Arg Asn Lys Phe  Gly Arg Gly Ser Arg  Asn Tyr Arg 
    2765                 2770                 2775             


Val Thr  Lys Tyr Tyr Asp Asp  Asn Leu Ser Glu Ile  Lys Pro Val 
    2780                 2785                 2790             


Ile Arg  Met Glu Gly His Val  Glu Leu Tyr Tyr Lys  Gly Ala Thr 
    2795                 2800                 2805             


Ile Lys  Leu Asp Phe Asn Asn  Ser Lys Thr Val Leu  Ala Thr Asp 
    2810                 2815                 2820             


Lys Trp  Glu Val Asp His Ser  Thr Leu Val Arg Ala  Leu Lys Arg 
    2825                 2830                 2835             


His Thr  Gly Ala Gly Tyr Gln  Gly Ala Tyr Met Gly  Glu Lys Pro 
    2840                 2845                 2850             


Asn His  Lys His Leu Ile Glu  Arg Asp Cys Ala Thr  Ile Thr Lys 
    2855                 2860                 2865             


Asp Lys  Val Tyr Phe Ile Lys  Met Lys Arg Gly Cys  Ala Phe Thr 
    2870                 2875                 2880             


Tyr Asp  Leu Ser Leu His Asn  Leu Thr Arg Leu Ile  Glu Leu Val 
    2885                 2890                 2895             


His Lys  Asn Asp Leu Glu Asp  Arg Glu Ile Pro Ala  Val Thr Val 
    2900                 2905                 2910             


Thr Thr  Trp Leu Ala Tyr Thr  Phe Val Asn Glu Asp  Ile Gly Thr 
    2915                 2920                 2925             


Ile Lys  Pro Val Phe Gly Glu  Lys Val Thr Pro Glu  Lys Gln Glu 
    2930                 2935                 2940             


Glu Val  Ala Leu Gln Pro Ala  Val Val Val Asp Thr  Thr Asp Val 
    2945                 2950                 2955             


Ala Val  Thr Val Val Gly Glu  Thr Ser Thr Met Thr  Thr Gly Glu 
    2960                 2965                 2970             


Thr Pro  Thr Ala Phe Thr Ser  Leu Gly Ser Asp Ser  Lys Val Gln 
    2975                 2980                 2985             


Gln Val  Leu Lys Leu Gly Val  Asp Glu Gly Gln Tyr  Pro Gly Pro 
    2990                 2995                 3000             


Ser Gln  Gln Arg Ala Ser Leu  Leu Asp Ala Ile Gln  Gly Val Asp 
    3005                 3010                 3015             


Glu Arg  Pro Ser Val Leu Ile  Leu Gly Ser Asp Lys  Ala Thr Ser 
    3020                 3025                 3030             


Asn Arg  Val Lys Thr Ala Lys  Asn Val Lys Ile Phe  Arg Ser Arg 
    3035                 3040                 3045             


Asp Pro  Leu Glu Leu Arg Glu  Met Met Arg Arg Gly  Lys Ile Leu 
    3050                 3055                 3060             


Val Ile  Ala Leu Cys Lys Val  Asp Thr Ala Leu Leu  Lys Phe Val 
    3065                 3070                 3075             


Asp Tyr  Lys Gly Thr Phe Leu  Thr Arg Glu Thr Leu  Glu Ala Leu 
    3080                 3085                 3090             


Ser Leu  Gly Lys Pro Lys Lys  Lys Asn Ile Thr Lys  Thr Glu Ala 
    3095                 3100                 3105             


Gln Trp  Leu Leu Cys Leu Glu  Asn Gln Ile Glu Glu  Leu Pro Asp 
    3110                 3115                 3120             


Trp Phe  Ala Ala Glu Glu Pro  Val Phe Leu Glu Ala  Asn Ile Lys 
    3125                 3130                 3135             


Arg Asp  Lys Tyr His Leu Val  Gly Asp Ile Ala Thr  Ile Lys Glu 
    3140                 3145                 3150             


Lys Ala  Lys Gln Leu Gly Ala  Thr Asp Ser Thr Lys  Ile Ser Lys 
    3155                 3160                 3165             


Glu Val  Gly Ala Lys Val Tyr  Ser Met Lys Leu Ser  Asn Trp Val 
    3170                 3175                 3180             


Ile Gln  Glu Glu Asn Lys Gln  Gly Ser Leu Ala Pro  Leu Phe Glu 
    3185                 3190                 3195             


Glu Leu  Leu Gln Gln Cys Pro  Pro Gly Gly Gln Asn  Lys Thr Thr 
    3200                 3205                 3210             


His Met  Val Ser Ala Tyr Gln  Leu Ala Gln Gly Asn  Trp Met Pro 
    3215                 3220                 3225             


Val Gly  Cys His Val Phe Met  Gly Thr Ile Pro Ala  Arg Arg Thr 
    3230                 3235                 3240             


Lys Thr  His Pro Tyr Glu Ala  Tyr Val Lys Leu Arg  Glu Leu Val 
    3245                 3250                 3255             


Asp Glu  Tyr Lys Met Lys Thr  Leu Cys Gly Gly Ser  Gly Leu Ser 
    3260                 3265                 3270             


Lys His  Asn Glu Trp Val Ile  Arg Lys Ile Lys His  Gln Gly Asn 
    3275                 3280                 3285             


Leu Arg  Thr Lys His Met Leu  Asn Pro Gly Lys Val  Ala Glu Gln 
    3290                 3295                 3300             


Leu Leu  Arg Glu Gly His Arg  His Asn Val Tyr Asn  Lys Thr Ile 
    3305                 3310                 3315             


Gly Ser  Val Met Thr Ala Thr  Gly Ile Arg Leu Glu  Lys Leu Pro 
    3320                 3325                 3330             


Val Val  Arg Ala Gln Thr Asp  Thr Thr Asn Phe His  Gln Ala Ile 
    3335                 3340                 3345             


Arg Asp  Lys Ile Asp Lys Glu  Glu Asn Leu Gln Thr  Pro Gly Leu 
    3350                 3355                 3360             


His Lys  Lys Leu Met Glu Val  Phe Asn Ala Leu Lys  Arg Pro Asp 
    3365                 3370                 3375             


Leu Glu  Ala Ser Tyr Asp Ala  Val Glu Trp Glu Glu  Leu Glu Lys 
    3380                 3385                 3390             


Gly Ile  Asn Arg Lys Gly Ala  Ala Gly Phe Phe Glu  His Lys Asn 
    3395                 3400                 3405             


Ile Gly  Glu Val Leu Asp Ser  Glu Lys Asn Lys Val  Glu Glu Ile 
    3410                 3415                 3420             


Ile Asp  Ser Leu Arg Lys Gly  Arg Ser Ile Arg Tyr  Tyr Glu Thr 
    3425                 3430                 3435             


Ala Ile  Pro Lys Asn Glu Lys  Arg Asp Val Asn Asp  Asp Trp Thr 
    3440                 3445                 3450             


Ala Gly  Asp Phe Val Asp Glu  Lys Lys Pro Arg Val  Ile Gln Tyr 
    3455                 3460                 3465             


Pro Glu  Ala Lys Thr Arg Leu  Ala Ile Thr Lys Val  Met Tyr Lys 
    3470                 3475                 3480             


Trp Val  Lys Gln Lys Pro Val  Val Ile Pro Gly Tyr  Glu Gly Lys 
    3485                 3490                 3495             


Thr Pro  Leu Phe Gln Ile Phe  Asp Lys Val Lys Lys  Glu Trp Asp 
    3500                 3505                 3510             


Gln Phe  Gln Asn Pro Val Ala  Val Ser Phe Asp Thr  Lys Ala Trp 
    3515                 3520                 3525             


Asp Thr  Gln Val Thr Thr Gly  Asp Leu Glu Leu Ile  Arg Asp Ile 
    3530                 3535                 3540             


Gln Lys  Phe Tyr Phe Lys Lys  Lys Trp His Lys Phe  Ile Asp Thr 
    3545                 3550                 3555             


Leu Thr  Met His Met Ser Glu  Val Pro Val Ile Ser  Ala Asp Gly 
    3560                 3565                 3570             


Glu Val  Tyr Ile Arg Lys Gly  Gln Arg Gly Ser Gly  Gln Pro Asp 
    3575                 3580                 3585             


Thr Ser  Ala Gly Asn Ser Met  Leu Asn Val Leu Thr  Met Val Tyr 
    3590                 3595                 3600             


Ala Phe  Cys Glu Ala Thr Gly  Val Pro Tyr Lys Ser  Phe Asp Arg 
    3605                 3610                 3615             


Val Ala  Lys Ile His Val Cys  Gly Asp Asp Gly Phe  Leu Ile Thr 
    3620                 3625                 3630             


Glu Arg  Ala Leu Gly Glu Lys  Phe Ser Ser Lys Gly  Val Gln Ile 
    3635                 3640                 3645             


Leu Tyr  Glu Ala Gly Lys Pro  Gln Lys Ile Thr Glu  Gly Asp Lys 
    3650                 3655                 3660             


Met Lys  Val Ala Tyr Gln Phe  Asp Asp Ile Glu Phe  Cys Ser His 
    3665                 3670                 3675             


Thr Pro  Val Gln Val Arg Trp  Ser Asp Asn Thr Ser  Ser Tyr Met 
    3680                 3685                 3690             


Pro Gly  Arg Asn Thr Thr Thr  Ile Leu Ala Lys Met  Ala Thr Arg 
    3695                 3700                 3705             


Leu Asp  Ser Ser Gly Glu Arg  Gly Thr Ile Ala Tyr  Glu Lys Ala 
    3710                 3715                 3720             


Val Ala  Phe Ser Phe Leu Leu  Met Tyr Ser Trp Asn  Pro Leu Ile 
    3725                 3730                 3735             


Arg Arg  Ile Cys Leu Leu Val  Leu Ser Thr Glu Leu  Gln Val Arg 
    3740                 3745                 3750             


Pro Gly  Lys Ser Thr Thr Tyr  Tyr Tyr Glu Gly Asp  Pro Ile Ser 
    3755                 3760                 3765             


Ala Tyr  Lys Glu Val Ile Gly  His Asn Leu Phe Asp  Leu Lys Arg 
    3770                 3775                 3780             


Thr Ser  Phe Glu Lys Leu Ala  Lys Leu Asn Leu Ser  Met Ser Thr 
    3785                 3790                 3795             


Leu Gly  Val Trp Thr Arg His  Thr Ser Lys Arg Leu  Leu Gln Asp 
    3800                 3805                 3810             


Cys Val  Asn Val Gly Thr Lys  Glu Gly Asn Trp Leu  Val Asn Ala 
    3815                 3820                 3825             


Asp Arg  Leu Val Ser Ser Lys  Thr Gly Asn Arg Tyr  Ile Pro Gly 
    3830                 3835                 3840             


Glu Gly  His Thr Gln Gln Gly  Lys His Tyr Glu Glu  Leu Ile Leu 
    3845                 3850                 3855             


Ala Arg  Lys Pro Ile Ser Asn  Phe Glu Gly Thr Asp  Arg Tyr Asn 
    3860                 3865                 3870             


Leu Gly  Pro Ile Val Asn Val  Val Leu Arg Arg Leu  Arg Val Met 
    3875                 3880                 3885             


Met Met  Ala Leu Ile Gly Arg  Gly Val 
    3890                 3895         


<210>  22
<211>  3896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of QZ07-ddErnsHC-KARD

<400>  22

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Gly Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Ala Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Thr Gly Asp Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Ala Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys Gly Trp Cys Asn Trp Tyr Asn 
            340                 345                 350         


Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu Thr 
        355                 360                 365             


Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp Lys 
    370                 375                 380                 


Asn Thr Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr Thr 
385                 390                 395                 400 


Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr Val 
                405                 410                 415     


Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu Tyr 
            420                 425                 430         


Gly Asp His Glu Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr Leu Leu 
        435                 440                 445             


Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala Ala Arg 
    450                 455                 460                 


Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys Lys Leu 
465                 470                 475                 480 


Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser Pro Tyr 
                485                 490                 495     


Cys Asn Val Thr Arg Lys Ile Gly Tyr Ile Trp Tyr Thr Asn Asn Cys 
            500                 505                 510         


Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro Gly Lys 
        515                 520                 525             


Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met Gly Gly 
    530                 535                 540                 


His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Val Leu Ser Asp Phe 
545                 550                 555                 560 


Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr Ala Ile 
                565                 570                 575     


Pro Gln Ser Arg Asp Glu Pro Glu Val Cys Asp Thr Asn Gln Leu Asn 
            580                 585                 590         


Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser Val Trp 
        595                 600                 605             


Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro Tyr Glu 
    610                 615                 620                 


Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile Lys Leu 
625                 630                 635                 640 


Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser Ala Ser 
                645                 650                 655     


Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly Gln Val 
            660                 665                 670         


Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln Gly Arg 
        675                 680                 685             


Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn Glu 
    690                 695                 700                 


Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu Tyr 
705                 710                 715                 720 


Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys Thr 
                725                 730                 735     


Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg Tyr 
            740                 745                 750         


Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe Glu 
        755                 760                 765             


Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp Asp 
    770                 775                 780                 


Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys Gly 
785                 790                 795                 800 


Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val Cys 
                805                 810                 815     


Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro Thr 
            820                 825                 830         


Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro Phe 
        835                 840                 845             


Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp Leu 
    850                 855                 860                 


Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn Pro 
865                 870                 875                 880 


Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly Phe 
                885                 890                 895     


Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys Cys 
            900                 905                 910         


Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp Cys 
        915                 920                 925             


Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys Leu 
    930                 935                 940                 


Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu Gly 
945                 950                 955                 960 


Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro Val 
                965                 970                 975     


Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn Lys 
            980                 985                 990         


Tyr Tyr Glu Pro Arg Asp Ser Tyr  Phe Gln Gln Tyr Met  Leu Lys Gly 
        995                 1000                 1005             


Glu Tyr  Gln Tyr Trp Phe Asp  Leu Asp Val Thr Asp  His His Thr 
    1010                 1015                 1020             


Asp Tyr  Phe Ala Glu Phe Val  Val Leu Val Val Val  Ala Leu Leu 
    1025                 1030                 1035             


Gly Gly  Arg Tyr Val Leu Trp  Leu Ile Val Thr Tyr  Val Ile Leu 
    1040                 1045                 1050             


Thr Glu  Gln Leu Ala Ala Gly  Leu Gln Leu Gly Gln  Gly Glu Val 
    1055                 1060                 1065             


Val Leu  Ile Gly Asn Leu Ile  Thr His Thr Asp Asn  Glu Val Val 
    1070                 1075                 1080             


Val Tyr  Phe Leu Leu Leu Tyr  Leu Ile Ile Arg Asp  Glu Pro Ile 
    1085                 1090                 1095             


Lys Lys  Trp Ile Leu Leu Leu  Phe His Ala Met Thr  Asn Asn Pro 
    1100                 1105                 1110             


Val Lys  Thr Met Thr Val Ala  Leu Leu Met Ile Ser  Gly Val Ala 
    1115                 1120                 1125             


Lys Gly  Gly Lys Thr Asp Gly  Gly Trp Gln Arg Gln  Pro Glu Thr 
    1130                 1135                 1140             


Asn Phe  Asp Ile Gln Leu Ala  Leu Ala Val Ile Val  Val Val Val 
    1145                 1150                 1155             


Met Leu  Leu Ala Lys Arg Asp  Pro Thr Thr Phe Pro  Leu Val Ile 
    1160                 1165                 1170             


Thr Val  Ala Thr Leu Arg Thr  Ala Lys Ile Thr Asn  Gly Phe Ser 
    1175                 1180                 1185             


Thr Asp  Leu Ala Ile Ala Thr  Val Ser Ala Ala Leu  Leu Thr Trp 
    1190                 1195                 1200             


Thr Tyr  Ile Ser Asp Tyr Tyr  Lys Tyr Lys Thr Trp  Leu Gln Tyr 
    1205                 1210                 1215             


Leu Ile  Ser Thr Val Thr Gly  Ile Phe Leu Ile Arg  Val Leu Lys 
    1220                 1225                 1230             


Gly Ile  Gly Glu Leu Asp Met  His Ala Pro Thr Leu  Pro Ser His 
    1235                 1240                 1245             


Arg Pro  Leu Phe Tyr Ile Leu  Val Tyr Leu Ile Ser  Thr Ala Val 
    1250                 1255                 1260             


Val Thr  Arg Trp Asn Leu Asp  Val Ala Gly Leu Leu  Leu Gln Cys 
    1265                 1270                 1275             


Val Pro  Thr Leu Leu Met Val  Phe Thr Met Trp Ala  Asp Ile Leu 
    1280                 1285                 1290             


Thr Leu  Ile Leu Val Leu Pro  Thr Tyr Glu Leu Ala  Lys Leu Tyr 
    1295                 1300                 1305             


Tyr Leu  Lys Glu Val Lys Ile  Gly Thr Glu Arg Gly  Trp Leu Trp 
    1310                 1315                 1320             


Lys Thr  Asn Tyr Lys Arg Val  Asn Asp Ile Tyr Glu  Val Asp Gln 
    1325                 1330                 1335             


Ala Gly  Glu Gly Val Tyr Leu  Phe Pro Ser Lys Gln  Lys Thr Ser 
    1340                 1345                 1350             


Ala Ile  Thr Ser Thr Met Leu  Pro Leu Ile Lys Ala  Ile Leu Ile 
    1355                 1360                 1365             


Ser Cys  Ile Ser Asn Lys Trp  Gln Leu Ile Tyr Leu  Leu Tyr Leu 
    1370                 1375                 1380             


Ile Phe  Glu Val Ser Tyr Tyr  Leu His Lys Lys Val  Ile Asp Glu 
    1385                 1390                 1395             


Ile Ala  Gly Gly Thr Asn Phe  Val Ser Arg Leu Val  Ala Ala Leu 
    1400                 1405                 1410             


Ile Glu  Val Asn Trp Ala Phe  Asp Asn Glu Glu Val  Lys Gly Leu 
    1415                 1420                 1425             


Lys Lys  Phe Phe Leu Leu Ser  Ser Arg Val Lys Glu  Leu Val Ile 
    1430                 1435                 1440             


Lys His  Lys Val Arg Asn Glu  Val Val Ala Arg Trp  Phe Gly Asp 
    1445                 1450                 1455             


Glu Glu  Ile Tyr Gly Met Pro  Lys Leu Ile Gly Leu  Val Lys Ala 
    1460                 1465                 1470             


Ala Thr  Leu Ser Lys Asn Lys  His Cys Ile Leu Cys  Thr Val Cys 
    1475                 1480                 1485             


Glu Asp  Arg Asp Trp Arg Gly  Glu Thr Cys Pro Lys  Cys Gly Arg 
    1490                 1495                 1500             


Phe Gly  Pro Pro Val Ile Cys  Gly Met Thr Leu Ala  Asp Phe Glu 
    1505                 1510                 1515             


Glu Lys  His Tyr Lys Arg Ile  Phe Ile Arg Glu Asp  Gln Ser Asp 
    1520                 1525                 1530             


Gly Pro  Leu Arg Glu Glu Arg  Ala Gly Tyr Leu Gln  Tyr Arg Ala 
    1535                 1540                 1545             


Arg Gly  Gln Leu Phe Leu Arg  Asn Leu Pro Val Leu  Ala Thr Lys 
    1550                 1555                 1560             


Val Lys  Met Leu Leu Val Gly  Asn Leu Gly Thr Glu  Val Gly Asp 
    1565                 1570                 1575             


Leu Glu  His Leu Gly Trp Val  Leu Arg Gly Pro Ala  Val Cys Lys 
    1580                 1585                 1590             


Lys Val  Thr Glu His Glu Lys  Cys Ala Thr Ser Ile  Met Asp Lys 
    1595                 1600                 1605             


Leu Thr  Ala Phe Phe Gly Val  Met Pro Arg Gly Thr  Thr Pro Arg 
    1610                 1615                 1620             


Ala Pro  Val Arg Phe Pro Thr  Ser Leu Leu Lys Ile  Arg Arg Gly 
    1625                 1630                 1635             


Leu Glu  Thr Gly Trp Ala Tyr  Thr His Gln Gly Gly  Ile Ser Ser 
    1640                 1645                 1650             


Val Asp  His Val Thr Cys Gly  Lys Asp Leu Leu Val  Cys Asp Thr 
    1655                 1660                 1665             


Met Gly  Arg Thr Arg Val Val  Cys Gln Ser Asn Asn  Lys Met Thr 
    1670                 1675                 1680             


Asp Glu  Ser Glu Tyr Gly Val  Lys Thr Asp Ser Gly  Cys Pro Glu 
    1685                 1690                 1695             


Gly Ala  Arg Cys Tyr Val Phe  Asn Pro Glu Ala Val  Asn Ile Ser 
    1700                 1705                 1710             


Gly Thr  Lys Gly Ala Met Val  His Leu Gln Lys Thr  Gly Gly Glu 
    1715                 1720                 1725             


Phe Thr  Cys Val Thr Ala Ser  Gly Thr Pro Ala Phe  Phe Asp Leu 
    1730                 1735                 1740             


Lys Asn  Leu Lys Gly Trp Ser  Gly Leu Pro Ile Phe  Glu Ala Ser 
    1745                 1750                 1755             


Ser Gly  Arg Val Val Gly Arg  Val Lys Val Gly Lys  Asn Asp Asp 
    1760                 1765                 1770             


Ser Lys  Pro Thr Lys Leu Met  Ser Gly Ile Gln Thr  Val Ser Lys 
    1775                 1780                 1785             


Ser Ala  Thr Asp Leu Thr Glu  Met Val Lys Lys Ile  Thr Thr Met 
    1790                 1795                 1800             


Asn Arg  Gly Glu Phe Arg Gln  Ile Thr Leu Ala Thr  Gly Ala Gly 
    1805                 1810                 1815             


Lys Thr  Thr Glu Leu Pro Arg  Ser Val Ile Glu Glu  Ile Gly Arg 
    1820                 1825                 1830             


His Lys  Arg Val Leu Val Leu  Ile Pro Leu Arg Ala  Ala Ala Glu 
    1835                 1840                 1845             


Ser Val  Tyr Gln Tyr Met Arg  Gln Lys His Pro Ser  Ile Ala Phe 
    1850                 1855                 1860             


Asn Leu  Arg Ile Gly Glu Met  Lys Glu Gly His Met  Ala Thr Gly 
    1865                 1870                 1875             


Ile Thr  Tyr Ala Ser Tyr Gly  Tyr Phe Cys Gln Met  Pro Gln Pro 
    1880                 1885                 1890             


Lys Leu  Arg Ala Ala Met Val  Glu Tyr Ser Tyr Ile  Phe Leu Asp 
    1895                 1900                 1905             


Glu Tyr  His Cys Ala Thr Pro  Glu Gln Leu Ala Ile  Met Gly Lys 
    1910                 1915                 1920             


Ile His  Arg Phe Ser Glu Asn  Leu Arg Val Val Ala  Met Thr Ala 
    1925                 1930                 1935             


Thr Pro  Ala Gly Thr Val Thr  Thr Thr Gly Gln Lys  His Pro Ile 
    1940                 1945                 1950             


Glu Glu  Phe Ile Ala Pro Glu  Val Met Lys Gly Glu  Asp Leu Gly 
    1955                 1960                 1965             


Ser Glu  Tyr Leu Asp Ile Ala  Gly Leu Lys Ile Pro  Val Glu Glu 
    1970                 1975                 1980             


Met Lys  Asn Asn Met Leu Val  Phe Val Pro Thr Arg  Asn Met Ala 
    1985                 1990                 1995             


Val Glu  Ala Ala Lys Lys Leu  Lys Ala Lys Gly Tyr  Asn Ser Gly 
    2000                 2005                 2010             


Tyr Tyr  Tyr Ser Gly Glu Asp  Pro Ser Asn Leu Arg  Val Val Thr 
    2015                 2020                 2025             


Ser Gln  Ser Pro Tyr Val Val  Val Ala Thr Asn Ala  Ile Glu Ser 
    2030                 2035                 2040             


Gly Val  Thr Leu Pro Asp Leu  Asp Val Val Val Asp  Thr Gly Leu 
    2045                 2050                 2055             


Lys Cys  Glu Lys Arg Ile Arg  Leu Ser Pro Lys Met  Pro Phe Ile 
    2060                 2065                 2070             


Val Thr  Gly Leu Lys Arg Met  Ala Val Thr Ile Gly  Glu Gln Ala 
    2075                 2080                 2085             


Gln Arg  Arg Gly Arg Val Gly  Arg Val Lys Pro Gly  Arg Tyr Tyr 
    2090                 2095                 2100             


Arg Ser  Gln Glu Thr Pro Val  Gly Ser Lys Asp Tyr  His Tyr Asp 
    2105                 2110                 2115             


Leu Leu  Gln Ala Gln Arg Tyr  Gly Ile Glu Asp Gly  Ile Asn Ile 
    2120                 2125                 2130             


Thr Lys  Ser Phe Arg Glu Met  Asn Tyr Asp Trp Ser  Leu Tyr Glu 
    2135                 2140                 2145             


Glu Asp  Ser Leu Met Ile Thr  Gln Leu Glu Ile Leu  Asn Asn Leu 
    2150                 2155                 2160             


Leu Ile  Ser Glu Glu Leu Pro  Val Ala Val Lys Asn  Ile Met Ala 
    2165                 2170                 2175             


Arg Thr  Asp His Pro Glu Pro  Ile Gln Leu Ala Tyr  Asn Ser Tyr 
    2180                 2185                 2190             


Glu Thr  Gln Val Pro Val Leu  Phe Pro Lys Ile Arg  Asn Gly Glu 
    2195                 2200                 2205             


Val Thr  Asp Thr Tyr Asp Thr  Tyr Thr Phe Ile Asn  Ala Arg Lys 
    2210                 2215                 2220             


Leu Gly  Asp Asp Val Pro Pro  Tyr Val Tyr Ala Thr  Glu Asp Glu 
    2225                 2230                 2235             


Asp Leu  Ala Val Glu Leu Leu  Gly Leu Asp Trp Pro  Asp Pro Gly 
    2240                 2245                 2250             


Asn Gln  Gly Thr Val Glu Ala  Gly Arg Ala Leu Lys  Gln Val Val 
    2255                 2260                 2265             


Gly Leu  Ser Thr Ala Glu Asn  Ala Leu Leu Val Ala  Leu Phe Gly 
    2270                 2275                 2280             


Tyr Val  Gly Tyr Gln Ala Leu  Ser Lys Arg His Ile  Pro Val Val 
    2285                 2290                 2295             


Thr Asp  Ile Tyr Ser Val Glu  Asp His Arg Leu Glu  Asp Thr Thr 
    2300                 2305                 2310             


His Leu  Gln Tyr Ala Pro Asn  Ala Ile Lys Thr Glu  Gly Lys Glu 
    2315                 2320                 2325             


Thr Glu  Leu Lys Glu Leu Ala  Gln Gly Asp Val Gln  Arg Cys Val 
    2330                 2335                 2340             


Glu Ala  Met Thr Asn Tyr Ala  Arg Gly Gly Ile Gln  Phe Met Lys 
    2345                 2350                 2355             


Ser Gln  Ala Leu Gln Val Arg  Glu Thr Pro Thr Tyr  Lys Glu Thr 
    2360                 2365                 2370             


Met Asn  Thr Val Ala Asp Tyr  Val Lys Lys Phe Ile  Glu Ala Leu 
    2375                 2380                 2385             


Ser Asp  Ser Lys Glu Asp Ile  Leu Lys Tyr Gly Leu  Trp Gly Val 
    2390                 2395                 2400             


His Thr  Ala Leu Tyr Lys Ser  Ile Gly Ala Arg Leu  Gly His Glu 
    2405                 2410                 2415             


Thr Ala  Phe Ala Thr Leu Ala  Val Lys Trp Leu Ala  Phe Gly Gly 
    2420                 2425                 2430             


Glu Ser  Ile Ala Asp His Ile  Lys Gln Ala Ala Thr  Asp Leu Val 
    2435                 2440                 2445             


Val Tyr  Tyr Ile Ile Asn Arg  Pro Gln Phe Pro Gly  Asp Thr Glu 
    2450                 2455                 2460             


Thr Gln  Gln Glu Gly Arg Asn  Phe Val Ala Ser Leu  Leu Val Ser 
    2465                 2470                 2475             


Ala Leu  Ala Thr Tyr Thr Tyr  Lys Ser Trp Asn Tyr  Asn Asn Leu 
    2480                 2485                 2490             


Ser Lys  Ile Val Glu Pro Ala  Leu Ala Thr Leu Pro  Tyr Ala Ala 
    2495                 2500                 2505             


Lys Ala  Leu Lys Leu Phe Ala  Pro Thr Arg Leu Glu  Ser Val Val 
    2510                 2515                 2520             


Ile Leu  Ser Thr Ala Ile Tyr  Lys Thr Tyr Leu Ser  Ile Arg Arg 
    2525                 2530                 2535             


Gly Lys  Ser Asp Gly Leu Leu  Gly Thr Gly Val Ser  Ala Ala Met 
    2540                 2545                 2550             


Glu Ile  Met Ser Gln Asn Pro  Val Ser Val Gly Ile  Ala Val Met 
    2555                 2560                 2565             


Leu Gly  Val Gly Ala Val Ala  Ala His Asn Ala Ile  Glu Ala Ser 
    2570                 2575                 2580             


Glu Gln  Lys Arg Thr Leu Leu  Met Lys Val Phe Val  Lys Asn Phe 
    2585                 2590                 2595             


Leu Asp  Gln Ala Ala Thr Asp  Glu Leu Val Lys Glu  Ser Pro Glu 
    2600                 2605                 2610             


Lys Ile  Ile Met Ala Leu Phe  Glu Ala Val Gln Thr  Val Gly Asn 
    2615                 2620                 2625             


Pro Leu  Arg Leu Val Tyr His  Leu Tyr Gly Val Phe  Tyr Lys Gly 
    2630                 2635                 2640             


Trp Glu  Ala Lys Glu Leu Ala  Gln Arg Thr Ala Gly  Arg Asn Leu 
    2645                 2650                 2655             


Phe Thr  Leu Ile Met Phe Glu  Ala Val Glu Leu Leu  Gly Val Asp 
    2660                 2665                 2670             


Ser Glu  Gly Lys Ile Arg Gln  Leu Ser Ser Asn Tyr  Ile Leu Glu 
    2675                 2680                 2685             


Leu Leu  Tyr Lys Phe Arg Asp  Ser Ile Lys Ser Ser  Val Arg Glu 
    2690                 2695                 2700             


Ile Ala  Ile Ser Trp Ala Pro  Ala Pro Phe Ser Cys  Asp Trp Thr 
    2705                 2710                 2715             


Pro Thr  Asp Asp Arg Ile Gly  Leu Pro His Asn Asn  Tyr Leu Gln 
    2720                 2725                 2730             


Met Glu  Thr Arg Cys Pro Cys  Gly Tyr Arg Met Lys  Ala Val Lys 
    2735                 2740                 2745             


Thr Cys  Ala Gly Glu Leu Arg  Leu Leu Glu Glu Gly  Gly Ser Phe 
    2750                 2755                 2760             


Leu Cys  Arg Asn Lys Phe Gly  Arg Gly Ser Arg Asn  Tyr Arg Val 
    2765                 2770                 2775             


Thr Lys  Tyr Tyr Asp Asp Asn  Leu Ser Glu Ile Lys  Pro Val Ile 
    2780                 2785                 2790             


Arg Met  Glu Gly His Val Glu  Leu Tyr Tyr Lys Gly  Ala Thr Ile 
    2795                 2800                 2805             


Lys Leu  Asp Phe Asn Asn Ser  Lys Thr Val Leu Ala  Thr Asp Lys 
    2810                 2815                 2820             


Trp Glu  Val Asp His Ser Thr  Leu Val Arg Ala Leu  Lys Arg His 
    2825                 2830                 2835             


Thr Gly  Ala Gly Tyr Gln Gly  Ala Tyr Met Gly Glu  Lys Pro Asn 
    2840                 2845                 2850             


His Lys  His Leu Ile Glu Arg  Asp Cys Ala Thr Ile  Thr Lys Asp 
    2855                 2860                 2865             


Lys Val  Tyr Phe Ile Lys Met  Lys Arg Gly Cys Ala  Phe Thr Tyr 
    2870                 2875                 2880             


Asp Leu  Ser Leu His Asn Leu  Thr Arg Leu Ile Glu  Leu Val His 
    2885                 2890                 2895             


Lys Asn  Asp Leu Glu Asp Arg  Glu Ile Pro Ala Val  Thr Val Thr 
    2900                 2905                 2910             


Thr Trp  Leu Ala Tyr Thr Phe  Val Asn Glu Asp Ile  Gly Thr Ile 
    2915                 2920                 2925             


Lys Pro  Val Phe Gly Glu Lys  Val Thr Pro Glu Lys  Gln Glu Glu 
    2930                 2935                 2940             


Val Ala  Leu Gln Pro Ala Val  Val Val Asp Thr Thr  Asp Val Ala 
    2945                 2950                 2955             


Val Thr  Val Val Gly Glu Thr  Ser Thr Met Thr Thr  Gly Glu Thr 
    2960                 2965                 2970             


Pro Thr  Ala Phe Thr Ser Leu  Gly Ser Asp Ser Lys  Val Gln Gln 
    2975                 2980                 2985             


Val Leu  Lys Leu Gly Val Asp  Glu Gly Gln Tyr Pro  Gly Pro Ser 
    2990                 2995                 3000             


Gln Gln  Arg Ala Ser Leu Leu  Asp Ala Ile Gln Gly  Val Asp Glu 
    3005                 3010                 3015             


Arg Pro  Ser Val Leu Ile Leu  Gly Ser Asp Lys Ala  Thr Ser Asn 
    3020                 3025                 3030             


Arg Val  Lys Thr Ala Lys Asn  Val Lys Ile Phe Arg  Ser Arg Asp 
    3035                 3040                 3045             


Pro Leu  Glu Leu Arg Glu Met  Met Arg Arg Gly Lys  Ile Leu Val 
    3050                 3055                 3060             


Ile Ala  Leu Cys Lys Val Asp  Thr Ala Leu Leu Lys  Phe Val Asp 
    3065                 3070                 3075             


Tyr Lys  Gly Thr Phe Leu Thr  Arg Glu Thr Leu Glu  Ala Leu Ser 
    3080                 3085                 3090             


Leu Gly  Lys Pro Lys Lys Lys  Asn Ile Thr Lys Thr  Glu Ala Gln 
    3095                 3100                 3105             


Trp Leu  Leu Cys Leu Glu Asn  Gln Ile Glu Glu Leu  Pro Asp Trp 
    3110                 3115                 3120             


Phe Ala  Ala Glu Glu Pro Val  Phe Leu Glu Ala Asn  Ile Lys Arg 
    3125                 3130                 3135             


Asp Lys  Tyr His Leu Val Gly  Asp Ile Ala Thr Ile  Lys Glu Lys 
    3140                 3145                 3150             


Ala Lys  Gln Leu Gly Ala Thr  Asp Ser Thr Lys Ile  Ser Lys Glu 
    3155                 3160                 3165             


Val Gly  Ala Lys Val Tyr Ser  Met Lys Leu Ser Asn  Trp Val Ile 
    3170                 3175                 3180             


Gln Glu  Glu Asn Lys Gln Gly  Ser Leu Ala Pro Leu  Phe Glu Glu 
    3185                 3190                 3195             


Leu Leu  Gln Gln Cys Pro Pro  Gly Gly Gln Asn Lys  Thr Thr His 
    3200                 3205                 3210             


Met Val  Ser Ala Tyr Gln Leu  Ala Gln Gly Asn Trp  Met Pro Val 
    3215                 3220                 3225             


Gly Cys  His Val Phe Met Gly  Thr Ile Pro Ala Arg  Arg Thr Lys 
    3230                 3235                 3240             


Thr His  Pro Tyr Glu Ala Tyr  Val Lys Leu Arg Glu  Leu Val Asp 
    3245                 3250                 3255             


Glu Tyr  Lys Met Lys Thr Leu  Cys Gly Gly Ser Gly  Leu Ser Lys 
    3260                 3265                 3270             


His Asn  Glu Trp Val Ile Arg  Lys Ile Lys His Gln  Gly Asn Leu 
    3275                 3280                 3285             


Arg Thr  Lys His Met Leu Asn  Pro Gly Lys Val Ala  Glu Gln Leu 
    3290                 3295                 3300             


Leu Arg  Glu Gly His Arg His  Asn Val Tyr Asn Lys  Thr Ile Gly 
    3305                 3310                 3315             


Ser Val  Met Thr Ala Thr Gly  Ile Arg Leu Glu Lys  Leu Pro Val 
    3320                 3325                 3330             


Val Arg  Ala Gln Thr Asp Thr  Thr Asn Phe His Gln  Ala Ile Arg 
    3335                 3340                 3345             


Asp Lys  Ile Asp Lys Glu Glu  Asn Leu Gln Thr Pro  Gly Leu His 
    3350                 3355                 3360             


Lys Lys  Leu Met Glu Val Phe  Asn Ala Leu Lys Arg  Pro Asp Leu 
    3365                 3370                 3375             


Glu Ala  Ser Tyr Asp Ala Val  Glu Trp Glu Glu Leu  Glu Lys Gly 
    3380                 3385                 3390             


Ile Asn  Arg Lys Gly Ala Ala  Gly Phe Phe Glu His  Lys Asn Ile 
    3395                 3400                 3405             


Gly Glu  Val Leu Asp Ser Glu  Lys Asn Lys Val Glu  Glu Ile Ile 
    3410                 3415                 3420             


Asp Ser  Leu Arg Lys Gly Arg  Ser Ile Arg Tyr Tyr  Glu Thr Ala 
    3425                 3430                 3435             


Ile Pro  Lys Asn Glu Lys Arg  Asp Val Asn Asp Asp  Trp Thr Ala 
    3440                 3445                 3450             


Gly Asp  Phe Val Asp Glu Lys  Lys Pro Arg Val Ile  Gln Tyr Pro 
    3455                 3460                 3465             


Glu Ala  Lys Thr Arg Leu Ala  Ile Thr Lys Val Met  Tyr Lys Trp 
    3470                 3475                 3480             


Val Lys  Gln Lys Pro Val Val  Ile Pro Gly Tyr Glu  Gly Lys Thr 
    3485                 3490                 3495             


Pro Leu  Phe Gln Ile Phe Asp  Lys Val Lys Lys Glu  Trp Asp Gln 
    3500                 3505                 3510             


Phe Gln  Asn Pro Val Ala Val  Ser Phe Asp Thr Lys  Ala Trp Asp 
    3515                 3520                 3525             


Thr Gln  Val Thr Thr Gly Asp  Leu Glu Leu Ile Arg  Asp Ile Gln 
    3530                 3535                 3540             


Lys Phe  Tyr Phe Lys Lys Lys  Trp His Lys Phe Ile  Asp Thr Leu 
    3545                 3550                 3555             


Thr Met  His Met Ser Glu Val  Pro Val Ile Ser Ala  Asp Gly Glu 
    3560                 3565                 3570             


Val Tyr  Ile Arg Lys Gly Gln  Arg Gly Ser Gly Gln  Pro Asp Thr 
    3575                 3580                 3585             


Ser Ala  Gly Asn Ser Met Leu  Asn Val Leu Thr Met  Val Tyr Ala 
    3590                 3595                 3600             


Phe Cys  Glu Ala Thr Gly Val  Pro Tyr Lys Ser Phe  Asp Arg Val 
    3605                 3610                 3615             


Ala Lys  Ile His Val Cys Gly  Asp Asp Gly Phe Leu  Ile Thr Glu 
    3620                 3625                 3630             


Arg Ala  Leu Gly Glu Lys Phe  Ser Ser Lys Gly Val  Gln Ile Leu 
    3635                 3640                 3645             


Tyr Glu  Ala Gly Lys Pro Gln  Lys Ile Thr Glu Gly  Asp Lys Met 
    3650                 3655                 3660             


Lys Val  Ala Tyr Gln Phe Asp  Asp Ile Glu Phe Cys  Ser His Thr 
    3665                 3670                 3675             


Pro Val  Gln Val Arg Trp Ser  Asp Asn Thr Ser Ser  Tyr Met Pro 
    3680                 3685                 3690             


Gly Arg  Asn Thr Thr Thr Ile  Leu Ala Lys Met Ala  Thr Arg Leu 
    3695                 3700                 3705             


Asp Ser  Ser Gly Glu Arg Gly  Thr Ile Ala Tyr Glu  Lys Ala Val 
    3710                 3715                 3720             


Ala Phe  Ser Phe Leu Leu Met  Tyr Ser Trp Asn Pro  Leu Ile Arg 
    3725                 3730                 3735             


Arg Ile  Cys Leu Leu Val Leu  Ser Thr Glu Leu Gln  Val Arg Pro 
    3740                 3745                 3750             


Gly Lys  Ser Thr Thr Tyr Tyr  Tyr Glu Gly Asp Pro  Ile Ser Ala 
    3755                 3760                 3765             


Tyr Lys  Glu Val Ile Gly His  Asn Leu Phe Asp Leu  Lys Arg Thr 
    3770                 3775                 3780             


Ser Phe  Glu Lys Leu Ala Lys  Leu Asn Leu Ser Met  Ser Thr Leu 
    3785                 3790                 3795             


Gly Val  Trp Thr Arg His Thr  Ser Lys Arg Leu Leu  Gln Asp Cys 
    3800                 3805                 3810             


Val Asn  Val Gly Thr Lys Glu  Gly Asn Trp Leu Val  Asn Ala Asp 
    3815                 3820                 3825             


Arg Leu  Val Ser Ser Lys Thr  Gly Asn Arg Tyr Ile  Pro Gly Glu 
    3830                 3835                 3840             


Gly His  Thr Gln Gln Gly Lys  His Tyr Glu Glu Leu  Ile Leu Ala 
    3845                 3850                 3855             


Arg Lys  Pro Ile Ser Asn Phe  Glu Gly Thr Asp Arg  Tyr Asn Leu 
    3860                 3865                 3870             


Gly Pro  Ile Val Asn Val Val  Leu Arg Arg Leu Arg  Val Met Met 
    3875                 3880                 3885             


Met Ala  Leu Ile Gly Arg Gly  Val 
    3890                 3895     


<210>  23
<211>  3896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of GD18-ddErnsHC-KARD

<400>  23

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Ile Gly Val Glu Glu Pro Val Tyr Asp Ile Thr Gly Arg Pro Phe 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asn Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Glu Glu Ala Gln Leu Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Ala Gly Gly Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Thr Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys Gly Trp Cys Asn Trp Tyr Asn 
            340                 345                 350         


Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu Thr 
        355                 360                 365             


Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp Lys 
    370                 375                 380                 


Asn Ala Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr Thr 
385                 390                 395                 400 


Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr Ile 
                405                 410                 415     


Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu Tyr 
            420                 425                 430         


Gly Asp His Glu Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr Leu Leu 
        435                 440                 445             


Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala Ala Arg 
    450                 455                 460                 


Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys Lys Leu 
465                 470                 475                 480 


Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser Pro Tyr 
                485                 490                 495     


Cys Asn Val Thr Arg Lys Val Gly Tyr Ile Trp Tyr Thr Asn Asn Cys 
            500                 505                 510         


Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro Gly Lys 
        515                 520                 525             


Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met Gly Gly 
    530                 535                 540                 


His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Ile Leu Ser Asp Phe 
545                 550                 555                 560 


Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr Ala Ile 
                565                 570                 575     


Pro Gln Ser His Glu Glu Pro Glu Gly Cys Asp Thr Asn Gln Leu Asn 
            580                 585                 590         


Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser Val Trp 
        595                 600                 605             


Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro Tyr Glu 
    610                 615                 620                 


Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile Lys Leu 
625                 630                 635                 640 


Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser Ala Ser 
                645                 650                 655     


Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly Gln Val 
            660                 665                 670         


Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln Gly Arg 
        675                 680                 685             


Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn Glu 
    690                 695                 700                 


Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu Tyr 
705                 710                 715                 720 


Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys Thr 
                725                 730                 735     


Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg Tyr 
            740                 745                 750         


Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe Glu 
        755                 760                 765             


Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp Asp 
    770                 775                 780                 


Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys Gly 
785                 790                 795                 800 


Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val Cys 
                805                 810                 815     


Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro Thr 
            820                 825                 830         


Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro Phe 
        835                 840                 845             


Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp Leu 
    850                 855                 860                 


Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp Pro 
865                 870                 875                 880 


Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly Phe 
                885                 890                 895     


Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys Cys 
            900                 905                 910         


Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp Cys 
        915                 920                 925             


Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys Leu 
    930                 935                 940                 


Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu Ala 
945                 950                 955                 960 


Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro Val 
                965                 970                 975     


Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn Lys 
            980                 985                 990         


Tyr Tyr Glu Pro Arg Asp Ser Tyr  Phe Gln Gln Tyr Met  Leu Lys Gly 
        995                 1000                 1005             


Glu Tyr  Gln Tyr Trp Phe Asp  Leu Asp Val Thr Asp  His His Thr 
    1010                 1015                 1020             


Asp Tyr  Phe Ala Glu Phe Val  Val Leu Val Val Val  Ala Leu Leu 
    1025                 1030                 1035             


Gly Gly  Arg Tyr Val Leu Trp  Leu Ile Val Thr Tyr  Ile Val Leu 
    1040                 1045                 1050             


Thr Glu  Gln Leu Ala Ala Gly  Leu Gln Leu Gly Gln  Gly Glu Val 
    1055                 1060                 1065             


Val Leu  Ile Gly Asn Leu Ile  Thr His Met Asp Asn  Glu Val Val 
    1070                 1075                 1080             


Val Tyr  Phe Leu Leu Leu Tyr  Leu Ile Ile Arg Asp  Glu Pro Ile 
    1085                 1090                 1095             


Lys Lys  Trp Ile Leu Leu Leu  Phe His Ala Met Thr  Asn Asn Pro 
    1100                 1105                 1110             


Val Lys  Thr Met Thr Val Ala  Leu Leu Met Ile Ser  Gly Val Ala 
    1115                 1120                 1125             


Lys Gly  Gly Lys Ile Asp Gly  Gly Trp Gln Arg Gln  Pro Glu Thr 
    1130                 1135                 1140             


Asn Phe  Asp Ile Gln Phe Ala  Leu Ala Val Ile Ile  Val Val Val 
    1145                 1150                 1155             


Met Leu  Leu Ala Lys Arg Asp  Pro Thr Thr Phe Pro  Leu Val Ile 
    1160                 1165                 1170             


Thr Val  Ala Thr Leu Arg Thr  Ala Lys Ile Thr Ser  Gly Phe Ser 
    1175                 1180                 1185             


Thr Asp  Leu Ala Ile Ala Thr  Val Ser Ala Thr Leu  Leu Thr Trp 
    1190                 1195                 1200             


Thr Tyr  Ile Ser Asp Tyr Tyr  Lys Tyr Lys Thr Trp  Leu Gln Tyr 
    1205                 1210                 1215             


Leu Ile  Ser Thr Val Thr Gly  Ile Phe Leu Ile Arg  Val Leu Lys 
    1220                 1225                 1230             


Gly Val  Gly Glu Leu Asp Leu  His Ala Pro Thr Leu  Pro Ser His 
    1235                 1240                 1245             


Arg Pro  Leu Phe Tyr Ile Leu  Val Tyr Leu Ile Ser  Thr Ala Val 
    1250                 1255                 1260             


Val Thr  Arg Trp Asn Leu Asp  Val Ala Gly Ile Leu  Leu Gln Cys 
    1265                 1270                 1275             


Ala Pro  Thr Leu Leu Met Val  Phe Thr Met Trp Ala  Asp Ile Leu 
    1280                 1285                 1290             


Thr Leu  Ile Leu Ile Leu Pro  Thr Tyr Glu Leu Thr  Lys Leu Tyr 
    1295                 1300                 1305             


Tyr Leu  Lys Glu Val Lys Ile  Gly Thr Glu Arg Gly  Trp Leu Trp 
    1310                 1315                 1320             


Lys Thr  Asn Tyr Lys Arg Val  Asn Asp Ile Tyr Glu  Val Asp Gln 
    1325                 1330                 1335             


Ala Gly  Glu Gly Val Tyr Leu  Phe Pro Ser Lys Gln  Lys Thr Gly 
    1340                 1345                 1350             


Ala Ile  Thr Ser Thr Val Leu  Pro Leu Ile Lys Ala  Ile Leu Ile 
    1355                 1360                 1365             


Ser Cys  Ile Ser Asn Lys Trp  Gln Phe Ile Tyr Leu  Leu Tyr Leu 
    1370                 1375                 1380             


Ile Phe  Glu Val Thr Tyr Tyr  Leu His Lys Lys Ile  Ile Asp Glu 
    1385                 1390                 1395             


Ile Ala  Gly Gly Thr Asn Phe  Val Ser Arg Leu Val  Ala Ala Leu 
    1400                 1405                 1410             


Ile Glu  Val Asn Trp Ala Leu  Asp Asn Glu Glu Val  Lys Gly Leu 
    1415                 1420                 1425             


Lys Lys  Phe Phe Leu Leu Ser  Ser Arg Val Lys Glu  Leu Val Ile 
    1430                 1435                 1440             


Lys His  Lys Val Arg Asn Glu  Val Met Val Arg Trp  Phe Glu Asp 
    1445                 1450                 1455             


Glu Glu  Ile Tyr Gly Met Pro  Lys Leu Ile Gly Leu  Val Lys Ala 
    1460                 1465                 1470             


Ala Thr  Leu Ser Lys Asn Lys  His Cys Ile Leu Cys  Thr Val Cys 
    1475                 1480                 1485             


Glu Asp  Arg Asp Trp Arg Gly  Glu Thr Cys Pro Lys  Cys Gly Arg 
    1490                 1495                 1500             


Phe Gly  Pro Pro Val Ile Cys  Gly Met Thr Leu Ala  Asp Phe Glu 
    1505                 1510                 1515             


Glu Lys  His Tyr Lys Arg Ile  Phe Ile Arg Glu Asp  Gln Ser Asp 
    1520                 1525                 1530             


Gly Pro  Leu Arg Glu Glu His  Ala Gly Tyr Leu Gln  Tyr Lys Ala 
    1535                 1540                 1545             


Arg Gly  Gln Leu Phe Leu Arg  Asn Leu Pro Val Leu  Ala Thr Lys 
    1550                 1555                 1560             


Val Lys  Met Leu Leu Val Gly  Asn Leu Gly Thr Glu  Val Gly Asp 
    1565                 1570                 1575             


Leu Glu  His Leu Gly Trp Val  Leu Arg Gly Pro Ala  Val Cys Lys 
    1580                 1585                 1590             


Lys Val  Thr Glu His Glu Lys  Cys Ala Thr Ser Ile  Met Asp Lys 
    1595                 1600                 1605             


Leu Thr  Ala Phe Phe Gly Val  Met Pro Arg Gly Thr  Thr Pro Arg 
    1610                 1615                 1620             


Ala Pro  Val Arg Phe Pro Thr  Ser Leu Leu Lys Ile  Arg Arg Gly 
    1625                 1630                 1635             


Leu Glu  Thr Gly Trp Ala Tyr  Thr His Gln Gly Gly  Ile Ser Ser 
    1640                 1645                 1650             


Val Asp  His Val Thr Cys Gly  Lys Asp Leu Leu Val  Cys Asp Thr 
    1655                 1660                 1665             


Met Gly  Arg Thr Arg Val Val  Cys Gln Ser Asn Asn  Lys Met Thr 
    1670                 1675                 1680             


Asp Glu  Ser Glu Tyr Gly Val  Lys Thr Asp Ser Gly  Cys Pro Glu 
    1685                 1690                 1695             


Gly Ala  Arg Cys Tyr Val Phe  Asn Pro Glu Ala Val  Asn Ile Ser 
    1700                 1705                 1710             


Gly Thr  Lys Gly Ala Met Val  His Leu Gln Lys Thr  Gly Gly Glu 
    1715                 1720                 1725             


Phe Thr  Cys Val Thr Ala Ser  Gly Thr Pro Ala Phe  Phe Asp Leu 
    1730                 1735                 1740             


Lys Asn  Leu Lys Gly Trp Ser  Gly Leu Pro Ile Phe  Glu Ala Ser 
    1745                 1750                 1755             


Ser Gly  Arg Val Val Gly Arg  Val Lys Val Gly Lys  Asn Glu Asp 
    1760                 1765                 1770             


Ser Lys  Pro Thr Lys Leu Met  Ser Gly Ile Gln Thr  Val Ser Lys 
    1775                 1780                 1785             


Ser Ala  Thr Asp Leu Thr Glu  Met Val Lys Lys Ile  Thr Thr Met 
    1790                 1795                 1800             


Asn Arg  Gly Glu Phe Arg Gln  Ile Thr Leu Ala Thr  Gly Ala Gly 
    1805                 1810                 1815             


Lys Thr  Thr Glu Leu Pro Arg  Ser Val Ile Glu Glu  Ile Gly Arg 
    1820                 1825                 1830             


His Lys  Arg Val Leu Val Leu  Ile Pro Leu Arg Ala  Ala Ala Glu 
    1835                 1840                 1845             


Ser Val  Tyr Gln Tyr Met Arg  Gln Lys His Pro Ser  Ile Ala Phe 
    1850                 1855                 1860             


Asn Leu  Arg Ile Gly Glu Met  Glu Glu Gly Tyr Met  Ala Thr Gly 
    1865                 1870                 1875             


Ile Thr  Tyr Ala Ser Tyr Gly  Tyr Phe Cys Gln Met  Pro Gln Pro 
    1880                 1885                 1890             


Lys Leu  Arg Ala Ala Met Val  Glu Tyr Ser Tyr Ile  Phe Leu Asp 
    1895                 1900                 1905             


Glu Tyr  His Cys Ala Thr Pro  Glu Gln Leu Ala Ile  Met Gly Lys 
    1910                 1915                 1920             


Ile His  Arg Phe Ser Glu Asn  Leu Arg Val Val Ala  Met Thr Ala 
    1925                 1930                 1935             


Thr Pro  Ala Gly Thr Val Thr  Thr Thr Gly Gln Lys  His Pro Ile 
    1940                 1945                 1950             


Glu Glu  Phe Ile Ala Pro Glu  Val Met Lys Gly Glu  Asp Leu Gly 
    1955                 1960                 1965             


Ser Glu  Tyr Leu Asp Ile Ala  Gly Leu Lys Ile Pro  Val Glu Glu 
    1970                 1975                 1980             


Met Lys  Asn Asn Met Leu Val  Phe Val Pro Thr Arg  Asn Met Ala 
    1985                 1990                 1995             


Val Glu  Ala Ala Lys Lys Leu  Lys Ala Lys Gly Tyr  Asn Ser Gly 
    2000                 2005                 2010             


Tyr Tyr  Tyr Ser Gly Glu Asp  Pro Ser Asn Leu Arg  Val Val Thr 
    2015                 2020                 2025             


Ser Gln  Ser Pro Tyr Val Val  Val Ala Thr Asn Ala  Ile Glu Ser 
    2030                 2035                 2040             


Gly Val  Thr Leu Pro Asp Leu  Asp Val Val Val Asp  Thr Gly Leu 
    2045                 2050                 2055             


Lys Cys  Glu Lys Arg Ile Arg  Leu Ser Pro Lys Met  Pro Phe Ile 
    2060                 2065                 2070             


Val Thr  Gly Leu Lys Arg Met  Ala Val Thr Ile Gly  Glu Gln Ala 
    2075                 2080                 2085             


Gln Arg  Arg Gly Arg Val Gly  Arg Val Lys Pro Gly  Arg Tyr Tyr 
    2090                 2095                 2100             


Arg Ser  Gln Glu Thr Pro Val  Gly Ser Lys Asp Tyr  His Tyr Asp 
    2105                 2110                 2115             


Leu Leu  Gln Ala Gln Arg Tyr  Gly Ile Glu Asp Gly  Ile Asn Ile 
    2120                 2125                 2130             


Thr Lys  Ser Phe Arg Glu Met  Asn Tyr Asp Trp Ser  Leu Tyr Glu 
    2135                 2140                 2145             


Glu Asp  Ser Leu Met Ile Thr  Gln Leu Glu Ile Leu  Asn Asn Leu 
    2150                 2155                 2160             


Leu Ile  Ser Glu Glu Leu Pro  Val Ala Val Lys Asn  Ile Met Ala 
    2165                 2170                 2175             


Arg Thr  Asp His Pro Glu Pro  Ile Gln Leu Ala Tyr  Asn Ser Tyr 
    2180                 2185                 2190             


Glu Thr  Gln Val Pro Val Leu  Phe Pro Lys Ile Arg  Asn Gly Glu 
    2195                 2200                 2205             


Val Thr  Asp Thr Tyr Asp Asn  Tyr Thr Phe Leu Asn  Ala Arg Lys 
    2210                 2215                 2220             


Leu Gly  Asp Asp Val Pro Pro  Tyr Val Tyr Ala Thr  Glu Asp Glu 
    2225                 2230                 2235             


Asp Leu  Ala Val Glu Leu Leu  Gly Leu Asp Trp Pro  Asp Pro Gly 
    2240                 2245                 2250             


Asn Gln  Gly Thr Val Glu Ala  Gly Arg Ala Leu Lys  Gln Val Val 
    2255                 2260                 2265             


Gly Leu  Ser Thr Ala Glu Asn  Ala Leu Leu Val Ala  Leu Phe Gly 
    2270                 2275                 2280             


Tyr Val  Gly Tyr Gln Ala Leu  Ser Lys Arg His Ile  Pro Val Val 
    2285                 2290                 2295             


Thr Asp  Ile Tyr Ser Val Glu  Asp His Arg Leu Glu  Asp Thr Thr 
    2300                 2305                 2310             


His Leu  Gln Tyr Ala Pro Asn  Ala Ile Lys Thr Glu  Gly Lys Glu 
    2315                 2320                 2325             


Thr Glu  Leu Lys Glu Leu Ala  Gln Gly Asp Val Gln  Arg Cys Val 
    2330                 2335                 2340             


Glu Ala  Val Ala Asn Tyr Ala  Ser Glu Gly Ile Gln  Phe Ile Lys 
    2345                 2350                 2355             


Ser Gln  Ala Leu Lys Val Arg  Glu Thr Pro Thr Tyr  Lys Glu Thr 
    2360                 2365                 2370             


Met Asn  Thr Val Ala Asp Tyr  Val Lys Lys Phe Ile  Glu Ala Leu 
    2375                 2380                 2385             


Ser Asp  Ser Lys Glu Asp Ile  Leu Lys Tyr Gly Leu  Trp Gly Val 
    2390                 2395                 2400             


His Thr  Ala Leu Tyr Lys Ser  Ile Gly Ala Arg Leu  Gly His Glu 
    2405                 2410                 2415             


Thr Ala  Phe Ala Thr Leu Val  Val Lys Trp Leu Ala  Phe Gly Gly 
    2420                 2425                 2430             


Glu Ser  Val Thr Asp His Ile  Lys Gln Ala Ala Thr  Asp Leu Val 
    2435                 2440                 2445             


Val Tyr  Tyr Ile Ile Asn Arg  Pro Gln Phe Pro Gly  Asp Thr Glu 
    2450                 2455                 2460             


Thr Gln  Gln Glu Gly Arg Lys  Phe Val Ala Ser Leu  Leu Val Ser 
    2465                 2470                 2475             


Ala Leu  Ala Thr Tyr Thr Tyr  Lys Ser Trp Asn Tyr  Asn Asn Leu 
    2480                 2485                 2490             


Ser Lys  Ile Val Glu Pro Ala  Leu Ala Thr Leu Pro  Tyr Ala Ala 
    2495                 2500                 2505             


Lys Ala  Leu Lys Leu Phe Ala  Pro Thr Arg Leu Glu  Ser Val Val 
    2510                 2515                 2520             


Ile Leu  Ser Thr Ala Ile Tyr  Lys Thr Tyr Leu Ser  Ile Arg Arg 
    2525                 2530                 2535             


Gly Lys  Ser Asp Gly Leu Leu  Gly Thr Gly Val Ser  Ala Ala Met 
    2540                 2545                 2550             


Glu Ile  Met Ser Gln Asn Pro  Val Ser Val Gly Ile  Ala Val Met 
    2555                 2560                 2565             


Leu Gly  Val Gly Ala Val Ala  Ala His Asn Ala Ile  Glu Ala Ser 
    2570                 2575                 2580             


Glu Gln  Lys Arg Thr Leu Leu  Met Lys Val Phe Val  Lys Asn Phe 
    2585                 2590                 2595             


Leu Asp  Gln Ala Ala Thr Asp  Glu Leu Val Lys Glu  Ser Pro Glu 
    2600                 2605                 2610             


Lys Ile  Ile Met Ala Leu Phe  Glu Ala Val Gln Thr  Val Gly Asn 
    2615                 2620                 2625             


Pro Leu  Arg Leu Val Tyr His  Leu Tyr Gly Val Phe  Tyr Lys Gly 
    2630                 2635                 2640             


Trp Glu  Ala Lys Glu Leu Ala  Gln Arg Thr Ala Gly  Arg Asn Leu 
    2645                 2650                 2655             


Phe Thr  Leu Ile Met Phe Glu  Ala Val Glu Leu Leu  Gly Val Asp 
    2660                 2665                 2670             


Ser Glu  Gly Lys Ile Arg Gln  Leu Ser Ser Asn Tyr  Ile Leu Glu 
    2675                 2680                 2685             


Leu Leu  Tyr Lys Phe Arg Asp  Asp Ile Lys Ser Ser  Val Arg Glu 
    2690                 2695                 2700             


Ile Ala  Ile Ser Trp Ala Pro  Ala Pro Phe Ser Cys  Asp Trp Thr 
    2705                 2710                 2715             


Pro Thr  Asp Asp Arg Ile Gly  Leu Pro His Asp Asn  Tyr Leu Gln 
    2720                 2725                 2730             


Met Glu  Thr Arg Cys Pro Cys  Gly Tyr Arg Met Lys  Ala Val Lys 
    2735                 2740                 2745             


Thr Cys  Ala Gly Glu Leu Arg  Leu Leu Glu Glu Gly  Gly Ser Phe 
    2750                 2755                 2760             


Leu Cys  Arg Asn Lys Phe Gly  Arg Gly Ser Arg Asn  Tyr Arg Val 
    2765                 2770                 2775             


Thr Lys  Tyr Tyr Asp Asp Asn  Leu Ser Glu Ile Lys  Pro Val Ile 
    2780                 2785                 2790             


Arg Met  Glu Gly His Val Glu  Leu Tyr His Lys Gly  Ala Thr Phe 
    2795                 2800                 2805             


Lys Leu  Asp Phe Asp Asn Ser  Lys Thr Val Leu Ala  Thr Asp Arg 
    2810                 2815                 2820             


Trp Glu  Val Asp His Ser Thr  Leu Ile Arg Val Leu  Lys Arg His 
    2825                 2830                 2835             


Thr Gly  Ala Gly Phe Gln Gly  Ala Tyr Leu Gly Glu  Lys Pro Asn 
    2840                 2845                 2850             


His Lys  His Leu Ile Glu Arg  Asp Cys Ala Thr Ile  Thr Lys Asp 
    2855                 2860                 2865             


Lys Val  Cys Phe Ile Lys Met  Lys Arg Gly Cys Ala  Phe Thr Tyr 
    2870                 2875                 2880             


Asp Leu  Ser Leu His Asn Leu  Thr Arg Leu Ile Glu  Leu Val His 
    2885                 2890                 2895             


Lys Asn  Asn Leu Asp Asp Arg  Glu Ile Pro Ala Val  Thr Val Thr 
    2900                 2905                 2910             


Thr Trp  Leu Ala Tyr Thr Phe  Val Asn Glu Asp Ile  Gly Thr Ile 
    2915                 2920                 2925             


Lys Pro  Val Phe Gly Glu Lys  Val Thr Pro Glu Lys  Gln Glu Glu 
    2930                 2935                 2940             


Val Ala  Leu Gln Pro Ala Val  Val Val Asp Thr Thr  Asp Val Ala 
    2945                 2950                 2955             


Val Thr  Val Val Gly Glu Thr  Ser Thr Met Thr Thr  Gly Glu Thr 
    2960                 2965                 2970             


Pro Thr  Ile Phe Thr Ser Leu  Gly Ser Asp Ser Lys  Phe Gln Gln 
    2975                 2980                 2985             


Val Leu  Lys Leu Gly Val Asp  Glu Gly Gln Tyr Pro  Gly Pro Arg 
    2990                 2995                 3000             


Gln Gln  Arg Ala Ser Leu Leu  Glu Ala Val Gln Gly  Val Asp Glu 
    3005                 3010                 3015             


Arg Pro  Ser Val Leu Ile Leu  Gly Ser Asp Lys Ala  Thr Ser Asn 
    3020                 3025                 3030             


Arg Val  Lys Thr Ala Lys Asn  Val Lys Ile Phe Arg  Ser Arg Asp 
    3035                 3040                 3045             


Pro Leu  Glu Leu Arg Glu Met  Met Arg Arg Gly Lys  Ile Leu Ile 
    3050                 3055                 3060             


Ile Ala  Leu Cys Lys Val Asp  Thr Ala Leu Leu Lys  Phe Val Asp 
    3065                 3070                 3075             


Tyr Lys  Gly Thr Phe Leu Thr  Arg Glu Thr Leu Glu  Ala Leu Ser 
    3080                 3085                 3090             


Leu Gly  Lys Pro Lys Lys Arg  Asp Ile Thr Lys Thr  Glu Ala Arg 
    3095                 3100                 3105             


Trp Leu  Leu Cys Leu Glu Gly  Gln Leu Glu Glu Leu  Pro Asp Trp 
    3110                 3115                 3120             


Phe Ala  Ala Lys Glu Pro Ile  Phe Leu Glu Ala Asn  Ile Lys Arg 
    3125                 3130                 3135             


Asp Lys  Tyr His Leu Val Gly  Asp Ile Ala Thr Ile  Lys Glu Lys 
    3140                 3145                 3150             


Ala Lys  Gln Leu Gly Ala Thr  Asp Ser Thr Lys Ile  Ser Lys Glu 
    3155                 3160                 3165             


Val Gly  Ala Lys Val Tyr Ser  Met Lys Leu Ser Asn  Trp Val Ile 
    3170                 3175                 3180             


Gln Glu  Glu Asn Lys Gln Gly  Ser Leu Thr Pro Leu  Phe Glu Glu 
    3185                 3190                 3195             


Leu Leu  Gln Gln Cys Pro Pro  Gly Gly Gln Asn Lys  Thr Thr His 
    3200                 3205                 3210             


Met Ala  Ser Ala Tyr Gln Leu  Ala Gln Gly Asn Trp  Met Pro Val 
    3215                 3220                 3225             


Gly Cys  His Val Phe Met Gly  Thr Ile Pro Ala Arg  Arg Thr Lys 
    3230                 3235                 3240             


Thr His  Pro Tyr Glu Ala Tyr  Val Lys Leu Arg Glu  Leu Val Glu 
    3245                 3250                 3255             


Glu His  Lys Met Lys Thr Ser  Cys Gly Gly Ser Gly  Leu Cys Lys 
    3260                 3265                 3270             


His Asn  Glu Trp Val Ile Arg  Lys Ile Lys His Gln  Gly Asn Leu 
    3275                 3280                 3285             


Arg Thr  Arg His Met Leu Asn  Pro Gly Lys Ile Ala  Glu Gln Leu 
    3290                 3295                 3300             


Asp Arg  Glu Gly His Arg His  Asn Val Tyr Asn Lys  Thr Ile Gly 
    3305                 3310                 3315             


Ser Val  Met Thr Ala Thr Gly  Ile Arg Leu Glu Lys  Leu Pro Val 
    3320                 3325                 3330             


Val Arg  Ala Gln Thr Asp Thr  Thr Asn Phe His Gln  Ala Ile Arg 
    3335                 3340                 3345             


Asp Lys  Ile Asp Lys Glu Glu  Asn Leu Gln Thr Pro  Gly Leu His 
    3350                 3355                 3360             


Lys Lys  Leu Met Glu Val Phe  Asn Ala Leu Lys Arg  Pro Glu Leu 
    3365                 3370                 3375             


Glu Ala  Ser Tyr Asp Ala Val  Glu Trp Glu Glu Leu  Glu Arg Gly 
    3380                 3385                 3390             


Ile Asn  Arg Lys Gly Ala Ala  Gly Phe Phe Glu Arg  Lys Asn Ile 
    3395                 3400                 3405             


Gly Glu  Val Leu Asp Ser Glu  Lys Tyr Lys Val Glu  Glu Ile Ile 
    3410                 3415                 3420             


Asp Ser  Leu Lys Lys Gly Arg  Ser Ile Lys Tyr Tyr  Glu Thr Ala 
    3425                 3430                 3435             


Ile Pro  Lys Asn Glu Lys Arg  Asp Val Asn Asp Asp  Trp Thr Ala 
    3440                 3445                 3450             


Gly Asp  Phe Val Asp Glu Lys  Lys Pro Arg Val Ile  Gln Tyr Pro 
    3455                 3460                 3465             


Glu Ala  Lys Thr Arg Leu Ala  Ile Thr Lys Val Met  Tyr Lys Trp 
    3470                 3475                 3480             


Val Lys  Gln Lys Pro Val Val  Ile Pro Gly Tyr Glu  Gly Lys Thr 
    3485                 3490                 3495             


Pro Leu  Phe Gln Ile Phe Asp  Lys Val Lys Lys Glu  Trp Asn Gln 
    3500                 3505                 3510             


Phe Gln  Asn Pro Val Ala Val  Ser Phe Asp Thr Lys  Ala Trp Asp 
    3515                 3520                 3525             


Thr Gln  Val Thr Thr Arg Asp  Leu Glu Leu Ile Arg  Asp Ile Gln 
    3530                 3535                 3540             


Lys Phe  Tyr Phe Lys Lys Lys  Trp His Lys Phe Ile  Asp Thr Leu 
    3545                 3550                 3555             


Thr Met  His Met Ser Glu Val  Pro Val Ile Ser Ala  Asp Gly Glu 
    3560                 3565                 3570             


Val Tyr  Ile Arg Lys Gly Gln  Arg Gly Ser Gly Gln  Pro Asp Thr 
    3575                 3580                 3585             


Ser Ala  Gly Asn Ser Met Leu  Asn Val Leu Thr Met  Val Tyr Ala 
    3590                 3595                 3600             


Phe Cys  Glu Ala Thr Gly Val  Pro Tyr Lys Ser Phe  Asp Arg Val 
    3605                 3610                 3615             


Ala Lys  Ile His Val Cys Gly  Asp Asp Gly Phe Leu  Ile Thr Glu 
    3620                 3625                 3630             


Arg Ala  Leu Gly Glu Lys Phe  Ala Ser Arg Gly Val  Gln Ile Leu 
    3635                 3640                 3645             


Tyr Glu  Ala Gly Lys Pro Gln  Lys Ile Thr Glu Gly  Asp Asn Met 
    3650                 3655                 3660             


Lys Val  Ala Tyr Gln Phe Asp  Asp Ile Glu Phe Cys  Ser His Thr 
    3665                 3670                 3675             


Pro Val  Gln Val Arg Trp Ser  Asp Asn Thr Ser Ser  Tyr Met Pro 
    3680                 3685                 3690             


Gly Arg  Asn Thr Thr Thr Ile  Leu Ala Lys Met Ala  Thr Arg Leu 
    3695                 3700                 3705             


Asp Ser  Ser Gly Glu Arg Gly  Thr Ile Ala Tyr Glu  Lys Ala Val 
    3710                 3715                 3720             


Ala Phe  Ser Phe Leu Leu Met  Tyr Ser Trp Asn Pro  Leu Ile Arg 
    3725                 3730                 3735             


Arg Ile  Cys Leu Leu Val Leu  Ser Thr Glu Met Gln  Val Arg Pro 
    3740                 3745                 3750             


Gly Lys  Ser Thr Thr Tyr Tyr  Tyr Glu Gly Asp Pro  Ile Ser Ala 
    3755                 3760                 3765             


Tyr Lys  Glu Val Ile Gly His  Asn Leu Phe Asp Leu  Lys Arg Thr 
    3770                 3775                 3780             


Ser Phe  Glu Lys Leu Ala Lys  Leu Asn Leu Ser Met  Ser Thr Leu 
    3785                 3790                 3795             


Gly Val  Trp Thr Arg His Thr  Ser Lys Arg Leu Leu  Gln Asp Cys 
    3800                 3805                 3810             


Val Asn  Val Gly Thr Lys Glu  Gly Asn Trp Leu Val  Asn Ala Asp 
    3815                 3820                 3825             


Arg Leu  Val Ser Ser Lys Thr  Gly Asn Arg Tyr Ile  Pro Gly Glu 
    3830                 3835                 3840             


Gly His  Thr Gln Gln Gly Lys  His Tyr Glu Glu Leu  Val Leu Ala 
    3845                 3850                 3855             


Arg Lys  Pro Thr Ser Asn Phe  Glu Gly Thr Asp Arg  Tyr Asn Leu 
    3860                 3865                 3870             


Gly Pro  Ile Val Asn Val Val  Leu Arg Arg Leu Arg  Val Met Met 
    3875                 3880                 3885             


Met Ala  Leu Ile Gly Arg Gly  Val 
    3890                 3895     


<210>  24
<211>  3733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of GD18-ddNproErnsH-KARD

<400>  24

Met Glu Leu Asn Ser Asp Asp Gly Ala Gly Gly Ser Lys Asp Lys Lys 
1               5                   10                  15      


Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala Pro Lys Glu His 
            20                  25                  30          


Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr Ile Val Val Glu 
        35                  40                  45              


Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val Lys Gly Lys Asn 
    50                  55                  60                  


Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro Pro Glu Ser Arg 
65                  70                  75                  80  


Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val Ile Thr Ile Val 
                85                  90                  95      


Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln Trp Asn Leu Ser 
            100                 105                 110         


Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr Leu Arg Gly Val 
        115                 120                 125             


Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile Cys Lys Gly Val 
    130                 135                 140                 


Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu Ile Arg Gly Met 
145                 150                 155                 160 


Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys Arg Leu Gln Arg 
                165                 170                 175     


His Glu Trp Asn Lys Gly Trp Cys Asn Trp Tyr Asn Ile Asp Pro Trp 
            180                 185                 190         


Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu Thr Glu Gly Pro Pro 
        195                 200                 205             


Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp Lys Asn Ala Asp Val 
    210                 215                 220                 


Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr Thr Leu Thr Gly Cys 
225                 230                 235                 240 


Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr Ile Ile Glu Gly Pro 
                245                 250                 255     


Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu Tyr Gly Asp His Glu 
            260                 265                 270         


Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr Leu Leu Asp Gly Met 
        275                 280                 285             


Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala Ala Arg Val Thr Ser 
    290                 295                 300                 


Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys Lys Leu Glu Arg Gly 
305                 310                 315                 320 


Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser Pro Tyr Cys Asn Val 
                325                 330                 335     


Thr Arg Lys Val Gly Tyr Ile Trp Tyr Thr Asn Asn Cys Thr Pro Ala 
            340                 345                 350         


Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro Gly Lys Phe Asp Thr 
        355                 360                 365             


Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met Gly Gly His Leu Ser 
    370                 375                 380                 


Glu Phe Leu Leu Leu Ser Leu Val Ile Leu Ser Asp Phe Ala Pro Glu 
385                 390                 395                 400 


Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr Ala Ile Pro Gln Ser 
                405                 410                 415     


His Glu Glu Pro Glu Gly Cys Asp Thr Asn Gln Leu Asn Leu Thr Val 
            420                 425                 430         


Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser Val Trp Asn Ile Gly 
        435                 440                 445             


Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro Tyr Glu Thr Lys Val 
    450                 455                 460                 


Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile Lys Leu Ala Leu Arg 
465                 470                 475                 480 


Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser Ala Ser Thr Thr Ala 
                485                 490                 495     


Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly Gln Val Val Gln Gly 
            500                 505                 510         


Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln Gly Arg Leu Thr Cys 
        515                 520                 525             


Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn Glu Ile Gly Pro 
    530                 535                 540                 


Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu Tyr Asn His Gly 
545                 550                 555                 560 


Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys Thr Ala Gly Ser 
                565                 570                 575     


Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg Tyr Leu Ala Ser 
            580                 585                 590         


Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe Glu Leu Leu Phe 
        595                 600                 605             


Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp Asp Phe Gly Phe 
    610                 615                 620                 


Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys Gly Lys Tyr Asn 
625                 630                 635                 640 


Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val Cys Pro Ile Gly 
                645                 650                 655     


Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro Thr Thr Leu Arg 
            660                 665                 670         


Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro Phe Pro His Arg 
        675                 680                 685             


Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp Leu Phe Tyr Cys 
    690                 695                 700                 


Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp Pro Val Thr Tyr 
705                 710                 715                 720 


Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly Phe Asn Phe Lys 
                725                 730                 735     


Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys Cys Ile Leu Ala 
            740                 745                 750         


Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp Cys Asn Arg Asp 
        755                 760                 765             


Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys Leu Ile Gly Asn 
    770                 775                 780                 


Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu Ala Pro Met Pro 
785                 790                 795                 800 


Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro Val Arg Lys Thr 
                805                 810                 815     


Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn Lys Tyr Tyr Glu 
            820                 825                 830         


Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys Gly Glu Tyr Gln 
        835                 840                 845             


Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr Asp Tyr Phe Ala 
    850                 855                 860                 


Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly Gly Arg Tyr Val 
865                 870                 875                 880 


Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu Gln Leu Ala Ala 
                885                 890                 895     


Gly Leu Gln Leu Gly Gln Gly Glu Val Val Leu Ile Gly Asn Leu Ile 
            900                 905                 910         


Thr His Met Asp Asn Glu Val Val Val Tyr Phe Leu Leu Leu Tyr Leu 
        915                 920                 925             


Ile Ile Arg Asp Glu Pro Ile Lys Lys Trp Ile Leu Leu Leu Phe His 
    930                 935                 940                 


Ala Met Thr Asn Asn Pro Val Lys Thr Met Thr Val Ala Leu Leu Met 
945                 950                 955                 960 


Ile Ser Gly Val Ala Lys Gly Gly Lys Ile Asp Gly Gly Trp Gln Arg 
                965                 970                 975     


Gln Pro Glu Thr Asn Phe Asp Ile Gln Phe Ala Leu Ala Val Ile Ile 
            980                 985                 990         


Val Val Val Met Leu Leu Ala Lys  Arg Asp Pro Thr Thr  Phe Pro Leu 
        995                 1000                 1005             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Ser Gly 
    1010                 1015                 1020             


Phe Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Ala  Thr Leu Leu 
    1025                 1030                 1035             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Trp Leu 
    1040                 1045                 1050             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1055                 1060                 1065             


Leu Lys  Gly Val Gly Glu Leu  Asp Leu His Ala Pro  Thr Leu Pro 
    1070                 1075                 1080             


Ser His  Arg Pro Leu Phe Tyr  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1085                 1090                 1095             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Val Ala Gly  Ile Leu Leu 
    1100                 1105                 1110             


Gln Cys  Ala Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1115                 1120                 1125             


Ile Leu  Thr Leu Ile Leu Ile  Leu Pro Thr Tyr Glu  Leu Thr Lys 
    1130                 1135                 1140             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Thr Glu  Arg Gly Trp 
    1145                 1150                 1155             


Leu Trp  Lys Thr Asn Tyr Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1160                 1165                 1170             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1175                 1180                 1185             


Thr Gly  Ala Ile Thr Ser Thr  Val Leu Pro Leu Ile  Lys Ala Ile 
    1190                 1195                 1200             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Phe Ile  Tyr Leu Leu 
    1205                 1210                 1215             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Ile Ile 
    1220                 1225                 1230             


Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Val Ser Arg  Leu Val Ala 
    1235                 1240                 1245             


Ala Leu  Ile Glu Val Asn Trp  Ala Leu Asp Asn Glu  Glu Val Lys 
    1250                 1255                 1260             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1265                 1270                 1275             


Val Ile  Lys His Lys Val Arg  Asn Glu Val Met Val  Arg Trp Phe 
    1280                 1285                 1290             


Glu Asp  Glu Glu Ile Tyr Gly  Met Pro Lys Leu Ile  Gly Leu Val 
    1295                 1300                 1305             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1310                 1315                 1320             


Val Cys  Glu Asp Arg Asp Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1325                 1330                 1335             


Gly Arg  Phe Gly Pro Pro Val  Ile Cys Gly Met Thr  Leu Ala Asp 
    1340                 1345                 1350             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Ile Arg  Glu Asp Gln 
    1355                 1360                 1365             


Ser Asp  Gly Pro Leu Arg Glu  Glu His Ala Gly Tyr  Leu Gln Tyr 
    1370                 1375                 1380             


Lys Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1385                 1390                 1395             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1400                 1405                 1410             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1415                 1420                 1425             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Ala Thr  Ser Ile Met 
    1430                 1435                 1440             


Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1445                 1450                 1455             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1460                 1465                 1470             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1475                 1480                 1485             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1490                 1495                 1500             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1505                 1510                 1515             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1520                 1525                 1530             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1535                 1540                 1545             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1550                 1555                 1560             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1565                 1570                 1575             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1580                 1585                 1590             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1595                 1600                 1605             


Glu Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1610                 1615                 1620             


Ser Lys  Ser Ala Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1625                 1630                 1635             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1640                 1645                 1650             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1655                 1660                 1665             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1670                 1675                 1680             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1685                 1690                 1695             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Glu Glu Gly  Tyr Met Ala 
    1700                 1705                 1710             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1715                 1720                 1725             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Tyr Ile Phe 
    1730                 1735                 1740             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1745                 1750                 1755             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1760                 1765                 1770             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1775                 1780                 1785             


Pro Ile  Glu Glu Phe Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1790                 1795                 1800             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1805                 1810                 1815             


Glu Glu  Met Lys Asn Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1820                 1825                 1830             


Met Ala  Val Glu Ala Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    1835                 1840                 1845             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    1850                 1855                 1860             


Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    1865                 1870                 1875             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    1880                 1885                 1890             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    1895                 1900                 1905             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    1910                 1915                 1920             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    1925                 1930                 1935             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    1940                 1945                 1950             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    1955                 1960                 1965             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    1970                 1975                 1980             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    1985                 1990                 1995             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Val Ala Val  Lys Asn Ile 
    2000                 2005                 2010             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2015                 2020                 2025             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Arg Asn 
    2030                 2035                 2040             


Gly Glu  Val Thr Asp Thr Tyr  Asp Asn Tyr Thr Phe  Leu Asn Ala 
    2045                 2050                 2055             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2060                 2065                 2070             


Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2075                 2080                 2085             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2090                 2095                 2100             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2105                 2110                 2115             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2120                 2125                 2130             


Val Val  Thr Asp Ile Tyr Ser  Val Glu Asp His Arg  Leu Glu Asp 
    2135                 2140                 2145             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2150                 2155                 2160             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2165                 2170                 2175             


Cys Val  Glu Ala Val Ala Asn  Tyr Ala Ser Glu Gly  Ile Gln Phe 
    2180                 2185                 2190             


Ile Lys  Ser Gln Ala Leu Lys  Val Arg Glu Thr Pro  Thr Tyr Lys 
    2195                 2200                 2205             


Glu Thr  Met Asn Thr Val Ala  Asp Tyr Val Lys Lys  Phe Ile Glu 
    2210                 2215                 2220             


Ala Leu  Ser Asp Ser Lys Glu  Asp Ile Leu Lys Tyr  Gly Leu Trp 
    2225                 2230                 2235             


Gly Val  His Thr Ala Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2240                 2245                 2250             


His Glu  Thr Ala Phe Ala Thr  Leu Val Val Lys Trp  Leu Ala Phe 
    2255                 2260                 2265             


Gly Gly  Glu Ser Val Thr Asp  His Ile Lys Gln Ala  Ala Thr Asp 
    2270                 2275                 2280             


Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2285                 2290                 2295             


Thr Glu  Thr Gln Gln Glu Gly  Arg Lys Phe Val Ala  Ser Leu Leu 
    2300                 2305                 2310             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2315                 2320                 2325             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2330                 2335                 2340             


Ala Ala  Lys Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2345                 2350                 2355             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2360                 2365                 2370             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2375                 2380                 2385             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Val  Gly Ile Ala 
    2390                 2395                 2400             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2405                 2410                 2415             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2420                 2425                 2430             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2435                 2440                 2445             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2450                 2455                 2460             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2465                 2470                 2475             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2480                 2485                 2490             


Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2495                 2500                 2505             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2510                 2515                 2520             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Asp Ile Lys  Ser Ser Val 
    2525                 2530                 2535             


Arg Glu  Ile Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2540                 2545                 2550             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro His  Asp Asn Tyr 
    2555                 2560                 2565             


Leu Gln  Met Glu Thr Arg Cys  Pro Cys Gly Tyr Arg  Met Lys Ala 
    2570                 2575                 2580             


Val Lys  Thr Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Gly Gly 
    2585                 2590                 2595             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2600                 2605                 2610             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2615                 2620                 2625             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr His  Lys Gly Ala 
    2630                 2635                 2640             


Thr Phe  Lys Leu Asp Phe Asp  Asn Ser Lys Thr Val  Leu Ala Thr 
    2645                 2650                 2655             


Asp Arg  Trp Glu Val Asp His  Ser Thr Leu Ile Arg  Val Leu Lys 
    2660                 2665                 2670             


Arg His  Thr Gly Ala Gly Phe  Gln Gly Ala Tyr Leu  Gly Glu Lys 
    2675                 2680                 2685             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2690                 2695                 2700             


Lys Asp  Lys Val Cys Phe Ile  Lys Met Lys Arg Gly  Cys Ala Phe 
    2705                 2710                 2715             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2720                 2725                 2730             


Val His  Lys Asn Asn Leu Asp  Asp Arg Glu Ile Pro  Ala Val Thr 
    2735                 2740                 2745             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2750                 2755                 2760             


Thr Ile  Lys Pro Val Phe Gly  Glu Lys Val Thr Pro  Glu Lys Gln 
    2765                 2770                 2775             


Glu Glu  Val Ala Leu Gln Pro  Ala Val Val Val Asp  Thr Thr Asp 
    2780                 2785                 2790             


Val Ala  Val Thr Val Val Gly  Glu Thr Ser Thr Met  Thr Thr Gly 
    2795                 2800                 2805             


Glu Thr  Pro Thr Ile Phe Thr  Ser Leu Gly Ser Asp  Ser Lys Phe 
    2810                 2815                 2820             


Gln Gln  Val Leu Lys Leu Gly  Val Asp Glu Gly Gln  Tyr Pro Gly 
    2825                 2830                 2835             


Pro Arg  Gln Gln Arg Ala Ser  Leu Leu Glu Ala Val  Gln Gly Val 
    2840                 2845                 2850             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    2855                 2860                 2865             


Ser Asn  Arg Val Lys Thr Ala  Lys Asn Val Lys Ile  Phe Arg Ser 
    2870                 2875                 2880             


Arg Asp  Pro Leu Glu Leu Arg  Glu Met Met Arg Arg  Gly Lys Ile 
    2885                 2890                 2895             


Leu Ile  Ile Ala Leu Cys Lys  Val Asp Thr Ala Leu  Leu Lys Phe 
    2900                 2905                 2910             


Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    2915                 2920                 2925             


Leu Ser  Leu Gly Lys Pro Lys  Lys Arg Asp Ile Thr  Lys Thr Glu 
    2930                 2935                 2940             


Ala Arg  Trp Leu Leu Cys Leu  Glu Gly Gln Leu Glu  Glu Leu Pro 
    2945                 2950                 2955             


Asp Trp  Phe Ala Ala Lys Glu  Pro Ile Phe Leu Glu  Ala Asn Ile 
    2960                 2965                 2970             


Lys Arg  Asp Lys Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    2975                 2980                 2985             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    2990                 2995                 3000             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  Ser Asn Trp 
    3005                 3010                 3015             


Val Ile  Gln Glu Glu Asn Lys  Gln Gly Ser Leu Thr  Pro Leu Phe 
    3020                 3025                 3030             


Glu Glu  Leu Leu Gln Gln Cys  Pro Pro Gly Gly Gln  Asn Lys Thr 
    3035                 3040                 3045             


Thr His  Met Ala Ser Ala Tyr  Gln Leu Ala Gln Gly  Asn Trp Met 
    3050                 3055                 3060             


Pro Val  Gly Cys His Val Phe  Met Gly Thr Ile Pro  Ala Arg Arg 
    3065                 3070                 3075             


Thr Lys  Thr His Pro Tyr Glu  Ala Tyr Val Lys Leu  Arg Glu Leu 
    3080                 3085                 3090             


Val Glu  Glu His Lys Met Lys  Thr Ser Cys Gly Gly  Ser Gly Leu 
    3095                 3100                 3105             


Cys Lys  His Asn Glu Trp Val  Ile Arg Lys Ile Lys  His Gln Gly 
    3110                 3115                 3120             


Asn Leu  Arg Thr Arg His Met  Leu Asn Pro Gly Lys  Ile Ala Glu 
    3125                 3130                 3135             


Gln Leu  Asp Arg Glu Gly His  Arg His Asn Val Tyr  Asn Lys Thr 
    3140                 3145                 3150             


Ile Gly  Ser Val Met Thr Ala  Thr Gly Ile Arg Leu  Glu Lys Leu 
    3155                 3160                 3165             


Pro Val  Val Arg Ala Gln Thr  Asp Thr Thr Asn Phe  His Gln Ala 
    3170                 3175                 3180             


Ile Arg  Asp Lys Ile Asp Lys  Glu Glu Asn Leu Gln  Thr Pro Gly 
    3185                 3190                 3195             


Leu His  Lys Lys Leu Met Glu  Val Phe Asn Ala Leu  Lys Arg Pro 
    3200                 3205                 3210             


Glu Leu  Glu Ala Ser Tyr Asp  Ala Val Glu Trp Glu  Glu Leu Glu 
    3215                 3220                 3225             


Arg Gly  Ile Asn Arg Lys Gly  Ala Ala Gly Phe Phe  Glu Arg Lys 
    3230                 3235                 3240             


Asn Ile  Gly Glu Val Leu Asp  Ser Glu Lys Tyr Lys  Val Glu Glu 
    3245                 3250                 3255             


Ile Ile  Asp Ser Leu Lys Lys  Gly Arg Ser Ile Lys  Tyr Tyr Glu 
    3260                 3265                 3270             


Thr Ala  Ile Pro Lys Asn Glu  Lys Arg Asp Val Asn  Asp Asp Trp 
    3275                 3280                 3285             


Thr Ala  Gly Asp Phe Val Asp  Glu Lys Lys Pro Arg  Val Ile Gln 
    3290                 3295                 3300             


Tyr Pro  Glu Ala Lys Thr Arg  Leu Ala Ile Thr Lys  Val Met Tyr 
    3305                 3310                 3315             


Lys Trp  Val Lys Gln Lys Pro  Val Val Ile Pro Gly  Tyr Glu Gly 
    3320                 3325                 3330             


Lys Thr  Pro Leu Phe Gln Ile  Phe Asp Lys Val Lys  Lys Glu Trp 
    3335                 3340                 3345             


Asn Gln  Phe Gln Asn Pro Val  Ala Val Ser Phe Asp  Thr Lys Ala 
    3350                 3355                 3360             


Trp Asp  Thr Gln Val Thr Thr  Arg Asp Leu Glu Leu  Ile Arg Asp 
    3365                 3370                 3375             


Ile Gln  Lys Phe Tyr Phe Lys  Lys Lys Trp His Lys  Phe Ile Asp 
    3380                 3385                 3390             


Thr Leu  Thr Met His Met Ser  Glu Val Pro Val Ile  Ser Ala Asp 
    3395                 3400                 3405             


Gly Glu  Val Tyr Ile Arg Lys  Gly Gln Arg Gly Ser  Gly Gln Pro 
    3410                 3415                 3420             


Asp Thr  Ser Ala Gly Asn Ser  Met Leu Asn Val Leu  Thr Met Val 
    3425                 3430                 3435             


Tyr Ala  Phe Cys Glu Ala Thr  Gly Val Pro Tyr Lys  Ser Phe Asp 
    3440                 3445                 3450             


Arg Val  Ala Lys Ile His Val  Cys Gly Asp Asp Gly  Phe Leu Ile 
    3455                 3460                 3465             


Thr Glu  Arg Ala Leu Gly Glu  Lys Phe Ala Ser Arg  Gly Val Gln 
    3470                 3475                 3480             


Ile Leu  Tyr Glu Ala Gly Lys  Pro Gln Lys Ile Thr  Glu Gly Asp 
    3485                 3490                 3495             


Asn Met  Lys Val Ala Tyr Gln  Phe Asp Asp Ile Glu  Phe Cys Ser 
    3500                 3505                 3510             


His Thr  Pro Val Gln Val Arg  Trp Ser Asp Asn Thr  Ser Ser Tyr 
    3515                 3520                 3525             


Met Pro  Gly Arg Asn Thr Thr  Thr Ile Leu Ala Lys  Met Ala Thr 
    3530                 3535                 3540             


Arg Leu  Asp Ser Ser Gly Glu  Arg Gly Thr Ile Ala  Tyr Glu Lys 
    3545                 3550                 3555             


Ala Val  Ala Phe Ser Phe Leu  Leu Met Tyr Ser Trp  Asn Pro Leu 
    3560                 3565                 3570             


Ile Arg  Arg Ile Cys Leu Leu  Val Leu Ser Thr Glu  Met Gln Val 
    3575                 3580                 3585             


Arg Pro  Gly Lys Ser Thr Thr  Tyr Tyr Tyr Glu Gly  Asp Pro Ile 
    3590                 3595                 3600             


Ser Ala  Tyr Lys Glu Val Ile  Gly His Asn Leu Phe  Asp Leu Lys 
    3605                 3610                 3615             


Arg Thr  Ser Phe Glu Lys Leu  Ala Lys Leu Asn Leu  Ser Met Ser 
    3620                 3625                 3630             


Thr Leu  Gly Val Trp Thr Arg  His Thr Ser Lys Arg  Leu Leu Gln 
    3635                 3640                 3645             


Asp Cys  Val Asn Val Gly Thr  Lys Glu Gly Asn Trp  Leu Val Asn 
    3650                 3655                 3660             


Ala Asp  Arg Leu Val Ser Ser  Lys Thr Gly Asn Arg  Tyr Ile Pro 
    3665                 3670                 3675             


Gly Glu  Gly His Thr Gln Gln  Gly Lys His Tyr Glu  Glu Leu Val 
    3680                 3685                 3690             


Leu Ala  Arg Lys Pro Thr Ser  Asn Phe Glu Gly Thr  Asp Arg Tyr 
    3695                 3700                 3705             


Asn Leu  Gly Pro Ile Val Asn  Val Val Leu Arg Arg  Leu Arg Val 
    3710                 3715                 3720             


Met Met  Met Ala Leu Ile Gly  Arg Gly Val 
    3725                 3730             


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  25

Ser Phe Gly Met His 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  26

Tyr Ile Ser Ser Asp Ser Phe Thr Ile Tyr Tyr Ala Asp Thr Met Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  27

Gly Asp Leu Pro Phe Ala Tyr 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  28

Lys Ala Ser Gln Ala Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  29

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  30

His Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with RD for GD18 or QZ07 or GD191

<400>  31

Ser Thr Asn Glu Ile Gly Pro Leu Gly Ala Arg Asp 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with RD for C-strain

<400>  32

Ser Thr Asp Glu Ile Gly Leu Leu Gly Ala Arg Asp 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KRD for C-strain

<400>  33

Lys Thr Asp Glu Ile Gly Leu Leu Gly Ala Arg Asp 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KARD for C-strain

<400>  34

Lys Thr Asp Glu Ile Gly Leu Leu Ala Ala Arg Asp 
1               5                   10          


<210>  35
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C strain-E2

<400>  35

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Gly Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala Thr Asp Arg His Ser 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


