                         SEQUENCE LISTING

<110>  Belief BioMed Limited
 
<120>  A NEW TYPE OF ENZYME COMPOSITION

<130>  075580-8001WO01

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  2
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of TH with a deletion of 90 amino acids

<400>  2

Pro Ser Glu Pro Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys 
1               5                   10                  15      


Glu Gly Lys Ala Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys 
            20                  25                  30          


Pro Ser Ala Leu Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala 
        35                  40                  45              


Lys Ile His His Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly 
    50                  55                  60                  


Gly Pro His Leu Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp 
65                  70                  75                  80  


Leu Ala Ala Leu Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg 
                85                  90                  95      


Ser Pro Ala Gly Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu 
            100                 105                 110         


Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp 
        115                 120                 125             


Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys 
    130                 135                 140                 


Leu Ile Ala Glu Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro 
145                 150                 155                 160 


Arg Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr 
                165                 170                 175     


Thr Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu 
            180                 185                 190         


Glu Ala Phe Ala Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn 
        195                 200                 205             


Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly 
    210                 215                 220                 


Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu 
225                 230                 235                 240 


Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His 
                245                 250                 255     


Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu 
            260                 265                 270         


Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser 
        275                 280                 285             


Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu 
    290                 295                 300                 


Lys Leu Ser Thr Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys 
305                 310                 315                 320 


Gln Asn Gly Glu Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr 
                325                 330                 335     


Gly Glu Leu Leu His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe 
            340                 345                 350         


Asp Pro Glu Ala Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln 
        355                 360                 365             


Ser Val Tyr Phe Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu 
    370                 375                 380                 


Arg Ser Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp 
385                 390                 395                 400 


Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg 
                405                 410                 415     


Arg Ser Leu Glu Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala 
            420                 425                 430         


Leu Ser Ala Ile Gly 
        435         


<210>  3
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of TH with an HA tag and a deletion of 90 
       amino acids

<400>  3

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Pro Ser Glu Pro Gly Asp Pro Leu Glu Ala Val Ala Phe 
            20                  25                  30          


Glu Glu Lys Glu Gly Lys Ala Val Leu Asn Leu Leu Phe Ser Pro Arg 
        35                  40                  45              


Ala Thr Lys Pro Ser Ala Leu Ser Arg Ala Val Lys Val Phe Glu Thr 
    50                  55                  60                  


Phe Glu Ala Lys Ile His His Leu Glu Thr Arg Pro Ala Gln Arg Pro 
65                  70                  75                  80  


Arg Ala Gly Gly Pro His Leu Glu Tyr Phe Val Arg Leu Glu Val Arg 
                85                  90                  95      


Arg Gly Asp Leu Ala Ala Leu Leu Ser Gly Val Arg Gln Val Ser Glu 
            100                 105                 110         


Asp Val Arg Ser Pro Ala Gly Pro Lys Val Pro Trp Phe Pro Arg Lys 
        115                 120                 125             


Val Ser Glu Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro 
    130                 135                 140                 


Asp Leu Asp Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln 
145                 150                 155                 160 


Arg Arg Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr Arg His Gly Asp 
                165                 170                 175     


Pro Ile Pro Arg Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys 
            180                 185                 190         


Glu Val Tyr Thr Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Gly 
        195                 200                 205             


Glu His Leu Glu Ala Phe Ala Leu Leu Glu Arg Phe Ser Gly Tyr Arg 
    210                 215                 220                 


Glu Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu 
225                 230                 235                 240 


Arg Thr Gly Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg 
                245                 250                 255     


Asp Phe Leu Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr 
            260                 265                 270         


Ile Arg His Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys 
        275                 280                 285             


His Glu Leu Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala 
    290                 295                 300                 


Gln Phe Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu 
305                 310                 315                 320 


Glu Ile Glu Lys Leu Ser Thr Leu Tyr Trp Phe Thr Val Glu Phe Gly 
                325                 330                 335     


Leu Cys Lys Gln Asn Gly Glu Val Lys Ala Tyr Gly Ala Gly Leu Leu 
            340                 345                 350         


Ser Ser Tyr Gly Glu Leu Leu His Cys Leu Ser Glu Glu Pro Glu Ile 
        355                 360                 365             


Arg Ala Phe Asp Pro Glu Ala Ala Ala Val Gln Pro Tyr Gln Asp Gln 
    370                 375                 380                 


Thr Tyr Gln Ser Val Tyr Phe Val Ser Glu Ser Phe Ser Asp Ala Lys 
385                 390                 395                 400 


Asp Lys Leu Arg Ser Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val 
                405                 410                 415     


Lys Phe Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro Gln 
            420                 425                 430         


Ala Val Arg Arg Ser Leu Glu Gly Val Gln Asp Glu Leu Asp Thr Leu 
        435                 440                 445             


Ala His Ala Leu Ser Ala Ile Gly 
    450                 455     


<210>  4
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 1

<400>  4

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  5
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 2

<400>  5

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Ala Ala Ser Pro Ala Cys Thr Glu Leu Glu Thr Val Met 
65                  70                  75                  80  


Met Asp Trp Leu Gly Lys Met Leu Glu Leu Pro Lys Ala Phe Leu Asn 
                85                  90                  95      


Glu Lys Ala Gly Glu Gly Gly Gly Val Ile Gln Gly Ser Ala Ser Glu 
            100                 105                 110         


Ala Thr Leu Val Ala Leu Leu Ala Ala Arg Thr Lys Val Ile His Arg 
        115                 120                 125             


Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln Ala Ala Ile Met Glu Lys 
    130                 135                 140                 


Leu Val Ala Tyr Ser Ser Asp Gln Ala His Ser Ser Val Glu Arg Ala 
145                 150                 155                 160 


Gly Leu Ile Gly Gly Val Lys Leu Lys Ala Ile Pro Ser Asp Gly Asn 
                165                 170                 175     


Phe Ala Met Arg Ala Ser Ala Leu Gln Glu Ala Leu Glu Arg Asp Lys 
            180                 185                 190         


Ala Ala Gly Leu Ile Pro Phe Phe Met Val Ala Thr Leu Gly Thr Thr 
        195                 200                 205             


Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu Val Gly Pro Ile Cys Asn 
    210                 215                 220                 


Lys Glu Asp Ile Trp Leu His Val Asp Ala Ala Tyr Ala Gly Ser Ala 
225                 230                 235                 240 


Phe Ile Cys Pro Glu Phe Arg His Leu Leu Asn Gly Val Glu Phe Ala 
                245                 250                 255     


Asp Ser Phe Asn Phe Asn Pro His Lys Trp Leu Leu Val Asn Phe Asp 
            260                 265                 270         


Cys Ser Ala Met Trp Val Lys Lys Arg Thr Asp Leu Thr Gly Ala Phe 
        275                 280                 285             


Arg Leu Asp Pro Thr Tyr Leu Lys His Ser His Gln Asp Ser Gly Leu 
    290                 295                 300                 


Ile Thr Asp Tyr Arg His Trp Gln Ile Pro Leu Gly Arg Arg Phe Arg 
305                 310                 315                 320 


Ser Leu Lys Met Trp Phe Val Phe Arg Met Tyr Gly Val Lys Gly Leu 
                325                 330                 335     


Gln Ala Tyr Ile Arg Lys His Val Gln Leu Ser His Glu Phe Glu Ser 
            340                 345                 350         


Leu Val Arg Gln Asp Pro Arg Phe Glu Ile Cys Val Glu Val Ile Leu 
        355                 360                 365             


Gly Leu Val Cys Phe Arg Leu Lys Gly Ser Asn Lys Val Asn Glu Ala 
    370                 375                 380                 


Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys Ile His Leu Val Pro Cys 
385                 390                 395                 400 


His Leu Arg Asp Lys Phe Val Leu Arg Phe Ala Ile Cys Ser Arg Thr 
                405                 410                 415     


Val Glu Ser Ala His Val Gln Arg Ala Trp Glu His Ile Lys Glu Leu 
            420                 425                 430         


Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
        435                 440         


<210>  6
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 3

<400>  6

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Met Val 
            180                 185                 190         


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
        195                 200                 205             


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
    210                 215                 220                 


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
225                 230                 235                 240 


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
                245                 250                 255     


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
            260                 265                 270         


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
        275                 280                 285             


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
    290                 295                 300                 


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
305                 310                 315                 320 


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
                325                 330                 335     


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
            340                 345                 350         


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
        355                 360                 365             


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
    370                 375                 380                 


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
385                 390                 395                 400 


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
                405                 410                 415     


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
            420                 425                 430         


<210>  7
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 4

<400>  7

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala 
65                  70                  75                  80  


Ala Arg Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu 
                85                  90                  95      


Thr Gln Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln 
            100                 105                 110         


Ala His Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu 
        115                 120                 125             


Lys Ala Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu 
    130                 135                 140                 


Gln Glu Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe 
145                 150                 155                 160 


Met Val Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu 
                165                 170                 175     


Leu Glu Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val 
            180                 185                 190         


Asp Ala Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His 
        195                 200                 205             


Leu Leu Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His 
    210                 215                 220                 


Lys Trp Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys 
225                 230                 235                 240 


Arg Thr Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys 
                245                 250                 255     


His Ser His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln 
            260                 265                 270         


Ile Pro Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe 
        275                 280                 285             


Arg Met Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val 
    290                 295                 300                 


Gln Leu Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe 
305                 310                 315                 320 


Glu Ile Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys 
                325                 330                 335     


Gly Ser Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala 
            340                 345                 350         


Lys Lys Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu 
        355                 360                 365             


Arg Phe Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg 
    370                 375                 380                 


Ala Trp Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu 
385                 390                 395                 400 


Arg Glu 
        


<210>  8
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 5

<400>  8

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Met Val Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn 
145                 150                 155                 160 


Leu Leu Glu Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His 
                165                 170                 175     


Val Asp Ala Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg 
            180                 185                 190         


His Leu Leu Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro 
        195                 200                 205             


His Lys Trp Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys 
    210                 215                 220                 


Lys Arg Thr Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu 
225                 230                 235                 240 


Lys His Ser His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp 
                245                 250                 255     


Gln Ile Pro Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val 
            260                 265                 270         


Phe Arg Met Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His 
        275                 280                 285             


Val Gln Leu Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg 
    290                 295                 300                 


Phe Glu Ile Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu 
305                 310                 315                 320 


Lys Gly Ser Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser 
                325                 330                 335     


Ala Lys Lys Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val 
            340                 345                 350         


Leu Arg Phe Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln 
        355                 360                 365             


Arg Ala Trp Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala 
    370                 375                 380                 


Glu Arg Glu 
385         


<210>  9
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring amino acid sequence of full-length AADC 
       Isoform 6

<400>  9

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Ser Arg Gln Pro Val 
305                 310                 315                 320 


Arg Met Leu Arg Leu Lys Lys Thr Cys Leu Val Ser Ala Val Val Arg 
                325                 330                 335     


Arg Ser 
        


<210>  10
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-lenght AADC with myc tag attached to 
       C terminus

<400>  10

Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr Val 
1               5                   10                  15      


Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp Val 
            20                  25                  30          


Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln Glu 
        35                  40                  45              


Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile Met 
    50                  55                  60                  


Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe Pro 
65                  70                  75                  80  


Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly Ala 
                85                  90                  95      


Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr Glu 
            100                 105                 110         


Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu Pro 
        115                 120                 125             


Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile Gln 
    130                 135                 140                 


Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg Thr 
145                 150                 155                 160 


Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln Ala 
                165                 170                 175     


Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His Ser 
            180                 185                 190         


Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala Ile 
        195                 200                 205             


Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu Ala 
    210                 215                 220                 


Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val Ala 
225                 230                 235                 240 


Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu Val 
                245                 250                 255     


Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala Ala 
            260                 265                 270         


Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu Asn 
        275                 280                 285             


Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp Leu 
    290                 295                 300                 


Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr Asp 
305                 310                 315                 320 


Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser His 
                325                 330                 335     


Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro Leu 
            340                 345                 350         


Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met Tyr 
        355                 360                 365             


Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu Ser 
    370                 375                 380                 


His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile Cys 
385                 390                 395                 400 


Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser Asn 
                405                 410                 415     


Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys Ile 
            420                 425                 430         


His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe Ala 
        435                 440                 445             


Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp Glu 
    450                 455                 460                 


His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu Glu 
465                 470                 475                 480 


Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                485                 


<210>  11
<211>  1587
<212>  DNA
<213>  Homo sapiens

<400>  11
atgcccaccc ccgacgccac cacgccacag gccaagggct tccgcagggc cgtgtctgag       60

ctggacgcca agcaggcaga ggccatcatg gtaagagggc agggcgcccc ggggcccagc      120

ctcacaggct ctccgtggcc tggaactgca gccccagctg catcctacac ccccacccca      180

aggtccccgc ggttcattgg gcgcaggcag agcctcatcg aggacgcccg caaggagcgg      240

gaggcggcgg tggcagcagc ggccgctgca gtcccctcgg agcccgggga ccccctggag      300

gctgtggcct ttgaggagaa ggaggggaag gccgtgctaa acctgctctt ctccccgagg      360

gccaccaagc cctcggcgct gtcccgagct gtgaaggtgt ttgagacgtt tgaagccaaa      420

atccaccatc tagagacccg gcccgcccag aggccgcgag ctgggggccc ccacctggag      480

tacttcgtgc gcctcgaggt gcgccgaggg gacctggccg ccctgctcag tggtgtgcgc      540

caggtgtcag aggacgtgcg cagccccgcg gggcccaagg tcccctggtt cccaagaaaa      600

gtgtcagagc tggacaagtg tcatcacctg gtcaccaagt tcgaccctga cctggacttg      660

gaccacccgg gcttctcgga ccaggtgtac cgccagcgca ggaagctgat tgctgagatc      720

gccttccagt acaggcacgg cgacccgatt ccccgtgtgg agtacaccgc cgaggagatt      780

gccacctgga aggaggtcta caccacgctg aagggcctct acgccacgca cgcctgcggg      840

gagcacctgg aggcctttgc tttgctggag cgcttcagcg gctaccggga agacaatatc      900

ccccagctgg aggacgtctc ccgcttcctg aaggagcgca cgggcttcca gctgcggcct      960

gtggccggcc tgctgtccgc ccgggacttc ctggccagcc tggccttccg cgtgttccag     1020

tgcacccagt atatccgcca cgcgtcctcg cccatgcact cccctgagcc ggactgctgc     1080

cacgagctgc tggggcacgt gcccatgctg gccgaccgca ccttcgcgca gttctcgcag     1140

gacattggcc tggcgtccct gggggcctcg gatgaggaaa ttgagaagct gtccacgctg     1200

tactggttca cggtggagtt cgggctgtgt aagcagaacg gggaggtgaa ggcctatggt     1260

gccgggctgc tgtcctccta cggggagctc ctgcactgcc tgtctgagga gcctgagatt     1320

cgggccttcg accctgaggc tgcggccgtg cagccctacc aagaccagac gtaccagtca     1380

gtctacttcg tgtctgagag cttcagtgac gccaaggaca agctcaggag ctatgcctca     1440

cgcatccagc gccccttctc cgtgaagttc gacccgtaca cgctggccat cgacgtgctg     1500

gacagccccc aggccgtgcg gcgctccctg gagggtgtcc aggatgagct ggacaccctt     1560

gcccatgcgc tgagtgccat tggctag                                         1587


<210>  12
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding TH with a deletion of 90 amino acid

<400>  12
ccctcggagc ccggggaccc cctggaggct gtggcctttg aggagaagga ggggaaggcc       60

gtgctaaacc tgctcttctc cccgagggcc accaagccct cggcgctgtc ccgagctgtg      120

aaggtgtttg agacgtttga agccaaaatc caccatctag agacccggcc cgcccagagg      180

ccgcgagctg ggggccccca cctggagtac ttcgtgcgcc tcgaggtgcg ccgaggggac      240

ctggccgccc tgctcagtgg tgtgcgccag gtgtcagagg acgtgcgcag ccccgcgggg      300

cccaaggtcc cctggttccc aagaaaagtg tcagagctgg acaagtgtca tcacctggtc      360

accaagttcg accctgacct ggacttggac cacccgggct tctcggacca ggtgtaccgc      420

cagcgcagga agctgattgc tgagatcgcc ttccagtaca ggcacggcga cccgattccc      480

cgtgtggagt acaccgccga ggagattgcc acctggaagg aggtctacac cacgctgaag      540

ggcctctacg ccacgcacgc ctgcggggag cacctggagg cctttgcttt gctggagcgc      600

ttcagcggct accgggaaga caatatcccc cagctggagg acgtctcccg cttcctgaag      660

gagcgcacgg gcttccagct gcggcctgtg gccggcctgc tgtccgcccg ggacttcctg      720

gccagcctgg ccttccgcgt gttccagtgc acccagtata tccgccacgc gtcctcgccc      780

atgcactccc ctgagccgga ctgctgccac gagctgctgg ggcacgtgcc catgctggcc      840

gaccgcacct tcgcgcagtt ctcgcaggac attggcctgg cgtccctggg ggcctcggat      900

gaggaaattg agaagctgtc cacgctgtac tggttcacgg tggagttcgg gctgtgtaag      960

cagaacgggg aggtgaaggc ctatggtgcc gggctgctgt cctcctacgg ggagctcctg     1020

cactgcctgt ctgaggagcc tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag     1080

ccctaccaag accagacgta ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc     1140

aaggacaagc tcaggagcta tgcctcacgc atccagcgcc ccttctccgt gaagttcgac     1200

ccgtacacgc tggccatcga cgtgctggac agcccccagg ccgtgcggcg ctccctggag     1260

ggtgtccagg atgagctgga cacccttgcc catgcgctga gtgccattgg c              1311


<210>  13
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding TH with an HA tag and a deletion of 90 
       amino acids

<400>  13
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgctccc       60

tcggagcccg gggaccccct ggaggctgtg gcctttgagg agaaggaggg gaaggccgtg      120

ctaaacctgc tcttctcccc gagggccacc aagccctcgg cgctgtcccg agctgtgaag      180

gtgtttgaga cgtttgaagc caaaatccac catctagaga cccggcccgc ccagaggccg      240

cgagctgggg gcccccacct ggagtacttc gtgcgcctcg aggtgcgccg aggggacctg      300

gccgccctgc tcagtggtgt gcgccaggtg tcagaggacg tgcgcagccc cgcggggccc      360

aaggtcccct ggttcccaag aaaagtgtca gagctggaca agtgtcatca cctggtcacc      420

aagttcgacc ctgacctgga cttggaccac ccgggcttct cggaccaggt gtaccgccag      480

cgcaggaagc tgattgctga gatcgccttc cagtacaggc acggcgaccc gattccccgt      540

gtggagtaca ccgccgagga gattgccacc tggaaggagg tctacaccac gctgaagggc      600

ctctacgcca cgcacgcctg cggggagcac ctggaggcct ttgctttgct ggagcgcttc      660

agcggctacc gggaagacaa tatcccccag ctggaggacg tctcccgctt cctgaaggag      720

cgcacgggct tccagctgcg gcctgtggcc ggcctgctgt ccgcccggga cttcctggcc      780

agcctggcct tccgcgtgtt ccagtgcacc cagtatatcc gccacgcgtc ctcgcccatg      840

cactcccctg agccggactg ctgccacgag ctgctggggc acgtgcccat gctggccgac      900

cgcaccttcg cgcagttctc gcaggacatt ggcctggcgt ccctgggggc ctcggatgag      960

gaaattgaga agctgtccac gctgtactgg ttcacggtgg agttcgggct gtgtaagcag     1020

aacggggagg tgaaggccta tggtgccggg ctgctgtcct cctacgggga gctcctgcac     1080

tgcctgtctg aggagcctga gattcgggcc ttcgaccctg aggctgcggc cgtgcagccc     1140

taccaagacc agacgtacca gtcagtctac ttcgtgtctg agagcttcag tgacgccaag     1200

gacaagctca ggagctatgc ctcacgcatc cagcgcccct tctccgtgaa gttcgacccg     1260

tacacgctgg ccatcgacgt gctggacagc ccccaggccg tgcggcgctc cctggagggt     1320

gtccaggatg agctggacac ccttgcccat gcgctgagtg ccattggc                  1368


<210>  14
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant DNA sequence encoding full-length AADC Isoform 1

<400>  14
aacgcaagtg agtttcgaag gagagggaag gagatggtgg attacgtggc caactacatg       60

gaaggcattg agggacgcca ggtctaccct gacgtggagc ccgggtacct gcggccgctg      120

atccctgccg ctgcccctca ggagccagac acgtttgagg acatcatcaa cgacgttgag      180

aagataatca tgcctggggt gacgcactgg cacagcccct acttcttcgc ctacttcccc      240

actgccagct cgtacccggc catgcttgcg gacatgctgt gcggggccat tggctgcatc      300

ggcttctcct gggcggcaag cccagcatgc acagagctgg agactgtgat gatggactgg      360

ctcgggaaga tgctggaact accaaaggca tttttgaatg agaaagctgg agaaggggga      420

ggagtgatcc agggaagtgc cagtgaagcc accctggtgg ccctgctggc cgctcggacc      480

aaagtgatcc atcggctgca ggcagcgtcc ccagagctca cacaggccgc tatcatggag      540

aagctggtgg cttactcatc cgatcaggca cactcctcag tggaaagagc tgggttaatt      600

ggtggagtga aattaaaagc catcccctca gatggcaact tcgccatgcg tgcgtctgcc      660

ctgcaggaag ccctggagag agacaaagcg gctggcctga ttcctttctt tatggttgcc      720

accctgggga ccacaacatg ctgctccttt gacaatctct tagaagtcgg tcctatctgc      780

aacaaggaag acatatggct gcacgttgat gcagcctacg caggcagtgc attcatctgc      840

cctgagttcc ggcaccttct gaatggagtg gagtttgcag attcattcaa ctttaatccc      900

cacaaatggc tattggtgaa ttttgactgt tctgccatgt gggtgaaaaa gagaacagac      960

ttaacgggag cctttagact ggaccccact tacctgaagc acagccatca ggattcaggg     1020

cttatcactg actaccggca ttggcagata ccactgggca gaagatttcg ctctttgaaa     1080

atgtggtttg tatttaggat gtatggagtc aaaggactgc aggcttatat ccgcaagcat     1140

gtccagctgt cccatgagtt tgagtcactg gtgcgccagg acccccgctt tgaaatctgt     1200

gtggaagtca ttctggggct tgtctgcttt cggctaaagg gttccaacaa agtgaatgaa     1260

gctcttctgc aaagaataaa cagtgccaaa aaaatccact tggttccatg tcacctcagg     1320

gacaagtttg tcctgcgctt tgccatctgt tctcgcacgg tggaatctgc ccatgtgcag     1380

cgggcctggg aacacatcaa agagctggcg gccgacgtgc tgcgagcaga gagggag        1437


<210>  15
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Naturally-occurring DNA sequence encoding full-length AADC 
       Isoform 1

<400>  15
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggtgacgcac tggcacagcc cctacttctt cgcctacttc      240

cccactgcca gctcgtaccc ggccatgctt gcggacatgc tgtgcggggc cattggctgc      300

atcggcttct cctgggcggc aagcccagca tgcacagagc tggagactgt gatgatggac      360

tggctcggga agatgctgga actaccaaag gcatttttga atgagaaagc tggagaaggg      420

ggaggagtga tccagggaag tgccagtgaa gccaccctgg tggccctgct ggccgctcgg      480

accaaagtga tccatcggct gcaggcagcg tccccagagc tcacacaggc cgctatcatg      540

gagaagctgg tggcttactc atccgatcag gcacactcct cagtggaaag agctgggtta      600

attggtggag tgaaattaaa agccatcccc tcagatggca acttcgccat gcgtgcgtct      660

gccctgcagg aagccctgga gagagacaaa gcggctggcc tgattccttt ctttatggtt      720

gccaccctgg ggaccacaac atgctgctcc tttgacaatc tcttagaagt cggtcctatc      780

tgcaacaagg aagacatatg gctgcacgtt gatgcagcct acgcaggcag tgcattcatc      840

tgccctgagt tccggcacct tctgaatgga gtggagtttg cagattcatt caactttaat      900

ccccacaaat ggctattggt gaattttgac tgttctgcca tgtgggtgaa aaagagaaca      960

gacttaacgg gagcctttag actggacccc acttacctga agcacagcca tcaggattca     1020

gggcttatca ctgactaccg gcattggcag ataccactgg gcagaagatt tcgctctttg     1080

aaaatgtggt ttgtatttag gatgtatgga gtcaaaggac tgcaggctta tatccgcaag     1140

catgtccagc tgtcccatga gtttgagtca ctggtgcgcc aggatccccg ctttgaaatc     1200

tgtgtggaag tcattctggg gcttgtctgc tttcggctaa agggttccaa caaagtgaat     1260

gaagctcttc tgcaaagaat aaacagtgcc aaaaaaatcc acttggttcc atgtcacctc     1320

agggacaagt ttgtcctgcg ctttgccatc tgttctcgca cggtggaatc tgcccatgtg     1380

cagcgggcct gggaacacat caaagagctg gcggccgacg tgctgcgagc agagagggag     1440

tag                                                                   1443


<210>  16
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Naturally occurring DNA sequence encoding full-length AADC 
       Isoform 2

<400>  16
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggcggcaagc ccagcatgca cagagctgga gactgtgatg      240

atggactggc tcgggaagat gctggaacta ccaaaggcat ttttgaatga gaaagctgga      300

gaagggggag gagtgatcca gggaagtgcc agtgaagcca ccctggtggc cctgctggcc      360

gctcggacca aagtgatcca tcggctgcag gcagcgtccc cagagctcac acaggccgct      420

atcatggaga agctggtggc ttactcatcc gatcaggcac actcctcagt ggaaagagct      480

gggttaattg gtggagtgaa attaaaagcc atcccctcag atggcaactt cgccatgcgt      540

gcgtctgccc tgcaggaagc cctggagaga gacaaagcgg ctggcctgat tcctttcttt      600

atggttgcca ccctggggac cacaacatgc tgctcctttg acaatctctt agaagtcggt      660

cctatctgca acaaggaaga catatggctg cacgttgatg cagcctacgc aggcagtgca      720

ttcatctgcc ctgagttccg gcaccttctg aatggagtgg agtttgcaga ttcattcaac      780

tttaatcccc acaaatggct attggtgaat tttgactgtt ctgccatgtg ggtgaaaaag      840

agaacagact taacgggagc ctttagactg gaccccactt acctgaagca cagccatcag      900

gattcagggc ttatcactga ctaccggcat tggcagatac cactgggcag aagatttcgc      960

tctttgaaaa tgtggtttgt atttaggatg tatggagtca aaggactgca ggcttatatc     1020

cgcaagcatg tccagctgtc ccatgagttt gagtcactgg tgcgccagga tccccgcttt     1080

gaaatctgtg tggaagtcat tctggggctt gtctgctttc ggctaaaggg ttccaacaaa     1140

gtgaatgaag ctcttctgca aagaataaac agtgccaaaa aaatccactt ggttccatgt     1200

cacctcaggg acaagtttgt cctgcgcttt gccatctgtt ctcgcacggt ggaatctgcc     1260

catgtgcagc gggcctggga acacatcaaa gagctggcgg ccgacgtgct gcgagcagag     1320

agggagtag                                                             1329


<210>  17
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Naturally occurring DNA sequence encoding full-length AADC 
       Isoform 3

<400>  17
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggtgacgcac tggcacagcc cctacttctt cgcctacttc      240

cccactgcca gctcgtaccc ggccatgctt gcggacatgc tgtgcggggc cattggctgc      300

atcggcttct cctgggcggc aagcccagca tgcacagagc tggagactgt gatgatggac      360

tggctcggga agatgctgga actaccaaag gcatttttga atgagaaagc tggagaaggg      420

ggaggagtga tccagggaag tgccagtgaa gccaccctgg tggccctgct ggccgctcgg      480

accaaagtga tccatcggct gcaggcagcg tccccagagc tcacacaggc cgctatcatg      540

gagaagctgg tggcttactc atccgatcag atggttgcca ccctggggac cacaacatgc      600

tgctcctttg acaatctctt agaagtcggt cctatctgca acaaggaaga catatggctg      660

cacgttgatg cagcctacgc aggcagtgca ttcatctgcc ctgagttccg gcaccttctg      720

aatggagtgg agtttgcaga ttcattcaac tttaatcccc acaaatggct attggtgaat      780

tttgactgtt ctgccatgtg ggtgaaaaag agaacagact taacgggagc ctttagactg      840

gaccccactt acctgaagca cagccatcag gattcagggc ttatcactga ctaccggcat      900

tggcagatac cactgggcag aagatttcgc tctttgaaaa tgtggtttgt atttaggatg      960

tatggagtca aaggactgca ggcttatatc cgcaagcatg tccagctgtc ccatgagttt     1020

gagtcactgg tgcgccagga tccccgcttt gaaatctgtg tggaagtcat tctggggctt     1080

gtctgctttc ggctaaaggg ttccaacaaa gtgaatgaag ctcttctgca aagaataaac     1140

agtgccaaaa aaatccactt ggttccatgt cacctcaggg acaagtttgt cctgcgcttt     1200

gccatctgtt ctcgcacggt ggaatctgcc catgtgcagc gggcctggga acacatcaaa     1260

gagctggcgg ccgacgtgct gcgagcagag agggagtag                            1299


<210>  18
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Natually-ocurring DNA sequence encoding full-length AADC Isoform 
       4

<400>  18
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg gggaagtgcc agtgaagcca ccctggtggc cctgctggcc      240

gctcggacca aagtgatcca tcggctgcag gcagcgtccc cagagctcac acaggccgct      300

atcatggaga agctggtggc ttactcatcc gatcaggcac actcctcagt ggaaagagct      360

gggttaattg gtggagtgaa attaaaagcc atcccctcag atggcaactt cgccatgcgt      420

gcgtctgccc tgcaggaagc cctggagaga gacaaagcgg ctggcctgat tcctttcttt      480

atggttgcca ccctggggac cacaacatgc tgctcctttg acaatctctt agaagtcggt      540

cctatctgca acaaggaaga catatggctg cacgttgatg cagcctacgc aggcagtgca      600

ttcatctgcc ctgagttccg gcaccttctg aatggagtgg agtttgcaga ttcattcaac      660

tttaatcccc acaaatggct attggtgaat tttgactgtt ctgccatgtg ggtgaaaaag      720

agaacagact taacgggagc ctttagactg gaccccactt acctgaagca cagccatcag      780

gattcagggc ttatcactga ctaccggcat tggcagatac cactgggcag aagatttcgc      840

tctttgaaaa tgtggtttgt atttaggatg tatggagtca aaggactgca ggcttatatc      900

cgcaagcatg tccagctgtc ccatgagttt gagtcactgg tgcgccagga tccccgcttt      960

gaaatctgtg tggaagtcat tctggggctt gtctgctttc ggctaaaggg ttccaacaaa     1020

gtgaatgaag ctcttctgca aagaataaac agtgccaaaa aaatccactt ggttccatgt     1080

cacctcaggg acaagtttgt cctgcgcttt gccatctgtt ctcgcacggt ggaatctgcc     1140

catgtgcagc gggcctggga acacatcaaa gagctggcgg ccgacgtgct gcgagcagag     1200

agggagtag                                                             1209


<210>  19
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Natually-ocurring DNA sequence encoding full-length AADC Isoform 
       5

<400>  19
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggtgacgcac tggcacagcc cctacttctt cgcctacttc      240

cccactgcca gctcgtaccc ggccatgctt gcggacatgc tgtgcggggc cattggctgc      300

atcggcttct cctgggcggc aagcccagca tgcacagagc tggagactgt gatgatggac      360

tggctcggga agatgctgga actaccaaag gcatttttga atgagaaagc tggagaaggg      420

ggaggagtga tccagatggt tgccaccctg gggaccacaa catgctgctc ctttgacaat      480

ctcttagaag tcggtcctat ctgcaacaag gaagacatat ggctgcacgt tgatgcagcc      540

tacgcaggca gtgcattcat ctgccctgag ttccggcacc ttctgaatgg agtggagttt      600

gcagattcat tcaactttaa tccccacaaa tggctattgg tgaattttga ctgttctgcc      660

atgtgggtga aaaagagaac agacttaacg ggagccttta gactggaccc cacttacctg      720

aagcacagcc atcaggattc agggcttatc actgactacc ggcattggca gataccactg      780

ggcagaagat ttcgctcttt gaaaatgtgg tttgtattta ggatgtatgg agtcaaagga      840

ctgcaggctt atatccgcaa gcatgtccag ctgtcccatg agtttgagtc actggtgcgc      900

caggatcccc gctttgaaat ctgtgtggaa gtcattctgg ggcttgtctg ctttcggcta      960

aagggttcca acaaagtgaa tgaagctctt ctgcaaagaa taaacagtgc caaaaaaatc     1020

cacttggttc catgtcacct cagggacaag tttgtcctgc gctttgccat ctgttctcgc     1080

acggtggaat ctgcccatgt gcagcgggcc tgggaacaca tcaaagagct ggcggccgac     1140

gtgctgcgag cagagaggga gtag                                            1164


<210>  20
<211>  1017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Natually-ocurring DNA sequence encoding full-length AADC Isoform 
       6

<400>  20
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggtgacgcac tggcacagcc cctacttctt cgcctacttc      240

cccactgcca gctcgtaccc ggccatgctt gcggacatgc tgtgcggggc cattggctgc      300

atcggcttct cctgggcggc aagcccagca tgcacagagc tggagactgt gatgatggac      360

tggctcggga agatgctgga actaccaaag gcatttttga atgagaaagc tggagaaggg      420

ggaggagtga tccagggaag tgccagtgaa gccaccctgg tggccctgct ggccgctcgg      480

accaaagtga tccatcggct gcaggcagcg tccccagagc tcacacaggc cgctatcatg      540

gagaagctgg tggcttactc atccgatcag gcacactcct cagtggaaag agctgggtta      600

attggtggag tgaaattaaa agccatcccc tcagatggca acttcgccat gcgtgcgtct      660

gccctgcagg aagccctgga gagagacaaa gcggctggcc tgattccttt ctttatggtt      720

gccaccctgg ggaccacaac atgctgctcc tttgacaatc tcttagaagt cggtcctatc      780

tgcaacaagg aagacatatg gctgcacgtt gatgcagcct acgcaggcag tgcattcatc      840

tgccctgagt tccggcacct tctgaatgga gtggagtttg cagattcatt caactttaat      900

ccccacaaat ggctattggt gaattttgac tgttctgcca tgtggtccag acaaccagtg      960

cgtatgttaa ggctgaagaa aacctgctta gtcagtgcgg tggtgagaag gagttga        1017


<210>  21
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding full-length AADC with myc tag attached to C
       terminus

<400>  21
aacgcaagtg agtttcgaag gagagggaag gagatggtgg attacgtggc caactacatg       60

gaaggcattg agggacgcca ggtctaccct gacgtggagc ccgggtacct gcggccgctg      120

atccctgccg ctgcccctca ggagccagac acgtttgagg acatcatcaa cgacgttgag      180

aagataatca tgcctggggt gacgcactgg cacagcccct acttcttcgc ctacttcccc      240

actgccagct cgtacccggc catgcttgcg gacatgctgt gcggggccat tggctgcatc      300

ggcttctcct gggcggcaag cccagcatgc acagagctgg agactgtgat gatggactgg      360

ctcgggaaga tgctggaact accaaaggca tttttgaatg agaaagctgg agaaggggga      420

ggagtgatcc agggaagtgc cagtgaagcc accctggtgg ccctgctggc cgctcggacc      480

aaagtgatcc atcggctgca ggcagcgtcc ccagagctca cacaggccgc tatcatggag      540

aagctggtgg cttactcatc cgatcaggca cactcctcag tggaaagagc tgggttaatt      600

ggtggagtga aattaaaagc catcccctca gatggcaact tcgccatgcg tgcgtctgcc      660

ctgcaggaag ccctggagag agacaaagcg gctggcctga ttcctttctt tatggttgcc      720

accctgggga ccacaacatg ctgctccttt gacaatctct tagaagtcgg tcctatctgc      780

aacaaggaag acatatggct gcacgttgat gcagcctacg caggcagtgc attcatctgc      840

cctgagttcc ggcaccttct gaatggagtg gagtttgcag attcattcaa ctttaatccc      900

cacaaatggc tattggtgaa ttttgactgt tctgccatgt gggtgaaaaa gagaacagac      960

ttaacgggag cctttagact ggaccccact tacctgaagc acagccatca ggattcaggg     1020

cttatcactg actaccggca ttggcagata ccactgggca gaagatttcg ctctttgaaa     1080

atgtggtttg tatttaggat gtatggagtc aaaggactgc aggcttatat ccgcaagcat     1140

gtccagctgt cccatgagtt tgagtcactg gtgcgccagg acccccgctt tgaaatctgt     1200

gtggaagtca ttctggggct tgtctgcttt cggctaaagg gttccaacaa agtgaatgaa     1260

gctcttctgc aaagaataaa cagtgccaaa aaaatccact tggttccatg tcacctcagg     1320

gacaagtttg tcctgcgctt tgccatctgt tctcgcacgg tggaatctgc ccatgtgcag     1380

cgggcctggg aacacatcaa agagctggcg gccgacgtgc tgcgagcaga gagggaggaa     1440

caaaaactca tctcagaaga ggatctg                                         1467


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of HA tag

<400>  22

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding HA tag

<400>  23
tacccatacg atgttccaga ttacgct                                           27


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequnce of Myc tag

<400>  24

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding Myc tag

<400>  25
gaacaaaaac tcatctcaga agaggatctg                                        30


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Flag tag

<400>  26

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding Flag tag

<400>  27
gactacaagg acgatgatga caag                                              24


<210>  28
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding T2A

<400>  28
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg ccca             54


