                         SEQUENCE LISTING

<110>  Inserm
 
<120>  USE OF JAK INHIBITORS FOR THE TREATMENT OF PAINFUL CONDITIONS 
       INVOLVING NAV1.7 CHANNELS

<130>  BIO19150 BODEMER/ MC

<160>  1     

<170>  PatentIn version 3.3

<210>  1
<211>  1988
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


