                         SEQUENCE LISTING

<110>  Xintela AB
 
<120>  Integrin alpha10 and aggressive cancer forms

<130>  P4894PC00

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1167
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1167)
<223>  Human integrin alpha 10 full length polypeptide

<400>  1

Met Glu Leu Pro Phe Val Thr His Leu Phe Leu Pro Leu Val Phe Leu 
1               5                   10                  15      


Thr Gly Leu Cys Ser Pro Phe Asn Leu Asp Glu His His Pro Arg Leu 
            20                  25                  30          


Phe Pro Gly Pro Pro Glu Ala Glu Phe Gly Tyr Ser Val Leu Gln His 
        35                  40                  45              


Val Gly Gly Gly Gln Arg Trp Met Leu Val Gly Ala Pro Trp Asp Gly 
    50                  55                  60                  


Pro Ser Gly Asp Arg Arg Gly Asp Val Tyr Arg Cys Pro Val Gly Gly 
65                  70                  75                  80  


Ala His Asn Ala Pro Cys Ala Lys Gly His Leu Gly Asp Tyr Gln Leu 
                85                  90                  95      


Gly Asn Ser Ser His Pro Ala Val Asn Met His Leu Gly Met Ser Leu 
            100                 105                 110         


Leu Glu Thr Asp Gly Asp Gly Gly Phe Met Ala Cys Ala Pro Leu Trp 
        115                 120                 125             


Ser Arg Ala Cys Gly Ser Ser Val Phe Ser Ser Gly Ile Cys Ala Arg 
    130                 135                 140                 


Val Asp Ala Ser Phe Gln Pro Gln Gly Ser Leu Ala Pro Thr Ala Gln 
145                 150                 155                 160 


Arg Cys Pro Thr Tyr Met Asp Val Val Ile Val Leu Asp Gly Ser Asn 
                165                 170                 175     


Ser Ile Tyr Pro Trp Ser Glu Val Gln Thr Phe Leu Arg Arg Leu Val 
            180                 185                 190         


Gly Lys Leu Phe Ile Asp Pro Glu Gln Ile Gln Val Gly Leu Val Gln 
        195                 200                 205             


Tyr Gly Glu Ser Pro Val His Glu Trp Ser Leu Gly Asp Phe Arg Thr 
    210                 215                 220                 


Lys Glu Glu Val Val Arg Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly 
225                 230                 235                 240 


Arg Glu Thr Lys Thr Ala Gln Ala Ile Met Val Ala Cys Thr Glu Gly 
                245                 250                 255     


Phe Ser Gln Ser His Gly Gly Arg Pro Glu Ala Ala Arg Leu Leu Val 
            260                 265                 270         


Val Val Thr Asp Gly Glu Ser His Asp Gly Glu Glu Leu Pro Ala Ala 
        275                 280                 285             


Leu Lys Ala Cys Glu Ala Gly Arg Val Thr Arg Tyr Gly Ile Ala Val 
    290                 295                 300                 


Leu Gly His Tyr Leu Arg Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg 
305                 310                 315                 320 


Glu Ile Arg Thr Ile Ala Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn 
                325                 330                 335     


Val Thr Asp Glu Ala Ala Leu Thr Asp Ile Val Asp Ala Leu Gly Asp 
            340                 345                 350         


Arg Ile Phe Gly Leu Glu Gly Ser His Ala Glu Asn Glu Ser Ser Phe 
        355                 360                 365             


Gly Leu Glu Met Ser Gln Ile Gly Phe Ser Thr His Arg Leu Lys Asp 
    370                 375                 380                 


Gly Ile Leu Phe Gly Met Val Gly Ala Tyr Asp Trp Gly Gly Ser Val 
385                 390                 395                 400 


Leu Trp Leu Glu Gly Gly His Arg Leu Phe Pro Pro Arg Met Ala Leu 
                405                 410                 415     


Glu Asp Glu Phe Pro Pro Ala Leu Gln Asn His Ala Ala Tyr Leu Gly 
            420                 425                 430         


Tyr Ser Val Ser Ser Met Leu Leu Arg Gly Gly Arg Arg Leu Phe Leu 
        435                 440                 445             


Ser Gly Ala Pro Arg Phe Arg His Arg Gly Lys Val Ile Ala Phe Gln 
    450                 455                 460                 


Leu Lys Lys Asp Gly Ala Val Arg Val Ala Gln Ser Leu Gln Gly Glu 
465                 470                 475                 480 


Gln Ile Gly Ser Tyr Phe Gly Ser Glu Leu Cys Pro Leu Asp Thr Asp 
                485                 490                 495     


Arg Asp Gly Thr Thr Asp Val Leu Leu Val Ala Ala Pro Met Phe Leu 
            500                 505                 510         


Gly Pro Gln Asn Lys Glu Thr Gly Arg Val Tyr Val Tyr Leu Val Gly 
        515                 520                 525             


Gln Gln Ser Leu Leu Thr Leu Gln Gly Thr Leu Gln Pro Glu Pro Pro 
    530                 535                 540                 


Gln Asp Ala Arg Phe Gly Phe Ala Met Gly Ala Leu Pro Asp Leu Asn 
545                 550                 555                 560 


Gln Asp Gly Phe Ala Asp Val Ala Val Gly Ala Pro Leu Glu Asp Gly 
                565                 570                 575     


His Gln Gly Ala Leu Tyr Leu Tyr His Gly Thr Gln Ser Gly Val Arg 
            580                 585                 590         


Pro His Pro Ala Gln Arg Ile Ala Ala Ala Ser Met Pro His Ala Leu 
        595                 600                 605             


Ser Tyr Phe Gly Arg Ser Val Asp Gly Arg Leu Asp Leu Asp Gly Asp 
    610                 615                 620                 


Asp Leu Val Asp Val Ala Val Gly Ala Gln Gly Ala Ala Ile Leu Leu 
625                 630                 635                 640 


Ser Ser Arg Pro Ile Val His Leu Thr Pro Ser Leu Glu Val Thr Pro 
                645                 650                 655     


Gln Ala Ile Ser Val Val Gln Arg Asp Cys Arg Arg Arg Gly Gln Glu 
            660                 665                 670         


Ala Val Cys Leu Thr Ala Ala Leu Cys Phe Gln Val Thr Ser Arg Thr 
        675                 680                 685             


Pro Gly Arg Trp Asp His Gln Phe Tyr Met Arg Phe Thr Ala Ser Leu 
    690                 695                 700                 


Asp Glu Trp Thr Ala Gly Ala Arg Ala Ala Phe Asp Gly Ser Gly Gln 
705                 710                 715                 720 


Arg Leu Ser Pro Arg Arg Leu Arg Leu Ser Val Gly Asn Val Thr Cys 
                725                 730                 735     


Glu Gln Leu His Phe His Val Leu Asp Thr Ser Asp Tyr Leu Arg Pro 
            740                 745                 750         


Val Ala Leu Thr Val Thr Phe Ala Leu Asp Asn Thr Thr Lys Pro Gly 
        755                 760                 765             


Pro Val Leu Asn Glu Gly Ser Pro Thr Ser Ile Gln Lys Leu Val Pro 
    770                 775                 780                 


Phe Ser Lys Asp Cys Gly Pro Asp Asn Glu Cys Val Thr Asp Leu Val 
785                 790                 795                 800 


Leu Gln Val Asn Met Asp Ile Arg Gly Ser Arg Lys Ala Pro Phe Val 
                805                 810                 815     


Val Arg Gly Gly Arg Arg Lys Val Leu Val Ser Thr Thr Leu Glu Asn 
            820                 825                 830         


Arg Lys Glu Asn Ala Tyr Asn Thr Ser Leu Ser Ile Ile Phe Ser Arg 
        835                 840                 845             


Asn Leu His Leu Ala Ser Leu Thr Pro Gln Arg Glu Ser Pro Ile Lys 
    850                 855                 860                 


Val Glu Cys Ala Ala Pro Ser Ala His Ala Arg Leu Cys Ser Val Gly 
865                 870                 875                 880 


His Pro Val Phe Gln Thr Gly Ala Lys Val Thr Phe Leu Leu Glu Phe 
                885                 890                 895     


Glu Phe Ser Cys Ser Ser Leu Leu Ser Gln Val Phe Gly Lys Leu Thr 
            900                 905                 910         


Ala Ser Ser Asp Ser Leu Glu Arg Asn Gly Thr Leu Gln Glu Asn Thr 
        915                 920                 925             


Ala Gln Thr Ser Ala Tyr Ile Gln Tyr Glu Pro His Leu Leu Phe Ser 
    930                 935                 940                 


Ser Glu Ser Thr Leu His Arg Tyr Glu Val His Pro Tyr Gly Thr Leu 
945                 950                 955                 960 


Pro Val Gly Pro Gly Pro Glu Phe Lys Thr Thr Leu Arg Val Gln Asn 
                965                 970                 975     


Leu Gly Cys Tyr Val Val Ser Gly Leu Ile Ile Ser Ala Leu Leu Pro 
            980                 985                 990         


Ala Val Ala His Gly Gly Asn Tyr  Phe Leu Ser Leu Ser  Gln Val Ile 
        995                 1000                 1005             


Thr Asn  Asn Ala Ser Cys Ile  Val Gln Asn Leu Thr  Glu Pro Pro 
    1010                 1015                 1020             


Gly Pro  Pro Val His Pro Glu  Glu Leu Gln His Thr  Asn Arg Leu 
    1025                 1030                 1035             


Asn Gly  Ser Asn Thr Gln Cys  Gln Val Val Arg Cys  His Leu Gly 
    1040                 1045                 1050             


Gln Leu  Ala Lys Gly Thr Glu  Val Ser Val Gly Leu  Leu Arg Leu 
    1055                 1060                 1065             


Val His  Asn Glu Phe Phe Arg  Arg Ala Lys Phe Lys  Ser Leu Thr 
    1070                 1075                 1080             


Val Val  Ser Thr Phe Glu Leu  Gly Thr Glu Glu Gly  Ser Val Leu 
    1085                 1090                 1095             


Gln Leu  Thr Glu Ala Ser Arg  Trp Ser Glu Ser Leu  Leu Glu Val 
    1100                 1105                 1110             


Val Gln  Thr Arg Pro Ile Leu  Ile Ser Leu Trp Ile  Leu Ile Gly 
    1115                 1120                 1125             


Ser Val  Leu Gly Gly Leu Leu  Leu Leu Ala Leu Leu  Val Phe Cys 
    1130                 1135                 1140             


Leu Trp  Lys Leu Gly Phe Phe  Ala His Lys Lys Ile  Pro Glu Glu 
    1145                 1150                 1155             


Glu Lys  Arg Glu Glu Lys Leu  Glu Gln 
    1160                 1165         


<210>  2
<211>  1100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1100)
<223>  Extracellular domain of human integrin alpha10

<400>  2

Phe Asn Leu Asp Glu His His Pro Arg Leu Phe Pro Gly Pro Pro Glu 
1               5                   10                  15      


Ala Glu Phe Gly Tyr Ser Val Leu Gln His Val Gly Gly Gly Gln Arg 
            20                  25                  30          


Trp Met Leu Val Gly Ala Pro Trp Asp Gly Pro Ser Gly Asp Arg Arg 
        35                  40                  45              


Gly Asp Val Tyr Arg Cys Pro Val Gly Gly Ala His Asn Ala Pro Cys 
    50                  55                  60                  


Ala Lys Gly His Leu Gly Asp Tyr Gln Leu Gly Asn Ser Ser His Pro 
65                  70                  75                  80  


Ala Val Asn Met His Leu Gly Met Ser Leu Leu Glu Thr Asp Gly Asp 
                85                  90                  95      


Gly Gly Phe Met Ala Cys Ala Pro Leu Trp Ser Arg Ala Cys Gly Ser 
            100                 105                 110         


Ser Val Phe Ser Ser Gly Ile Cys Ala Arg Val Asp Ala Ser Phe Gln 
        115                 120                 125             


Pro Gln Gly Ser Leu Ala Pro Thr Ala Gln Arg Cys Pro Thr Tyr Met 
    130                 135                 140                 


Asp Val Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Ser 
145                 150                 155                 160 


Glu Val Gln Thr Phe Leu Arg Arg Leu Val Gly Lys Leu Phe Ile Asp 
                165                 170                 175     


Pro Glu Gln Ile Gln Val Gly Leu Val Gln Tyr Gly Glu Ser Pro Val 
            180                 185                 190         


His Glu Trp Ser Leu Gly Asp Phe Arg Thr Lys Glu Glu Val Val Arg 
        195                 200                 205             


Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly Arg Glu Thr Lys Thr Ala 
    210                 215                 220                 


Gln Ala Ile Met Val Ala Cys Thr Glu Gly Phe Ser Gln Ser His Gly 
225                 230                 235                 240 


Gly Arg Pro Glu Ala Ala Arg Leu Leu Val Val Val Thr Asp Gly Glu 
                245                 250                 255     


Ser His Asp Gly Glu Glu Leu Pro Ala Ala Leu Lys Ala Cys Glu Ala 
            260                 265                 270         


Gly Arg Val Thr Arg Tyr Gly Ile Ala Val Leu Gly His Tyr Leu Arg 
        275                 280                 285             


Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg Glu Ile Arg Thr Ile Ala 
    290                 295                 300                 


Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn Val Thr Asp Glu Ala Ala 
305                 310                 315                 320 


Leu Thr Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Gly Leu Glu 
                325                 330                 335     


Gly Ser His Ala Glu Asn Glu Ser Ser Phe Gly Leu Glu Met Ser Gln 
            340                 345                 350         


Ile Gly Phe Ser Thr His Arg Leu Lys Asp Gly Ile Leu Phe Gly Met 
        355                 360                 365             


Val Gly Ala Tyr Asp Trp Gly Gly Ser Val Leu Trp Leu Glu Gly Gly 
    370                 375                 380                 


His Arg Leu Phe Pro Pro Arg Met Ala Leu Glu Asp Glu Phe Pro Pro 
385                 390                 395                 400 


Ala Leu Gln Asn His Ala Ala Tyr Leu Gly Tyr Ser Val Ser Ser Met 
                405                 410                 415     


Leu Leu Arg Gly Gly Arg Arg Leu Phe Leu Ser Gly Ala Pro Arg Phe 
            420                 425                 430         


Arg His Arg Gly Lys Val Ile Ala Phe Gln Leu Lys Lys Asp Gly Ala 
        435                 440                 445             


Val Arg Val Ala Gln Ser Leu Gln Gly Glu Gln Ile Gly Ser Tyr Phe 
    450                 455                 460                 


Gly Ser Glu Leu Cys Pro Leu Asp Thr Asp Arg Asp Gly Thr Thr Asp 
465                 470                 475                 480 


Val Leu Leu Val Ala Ala Pro Met Phe Leu Gly Pro Gln Asn Lys Glu 
                485                 490                 495     


Thr Gly Arg Val Tyr Val Tyr Leu Val Gly Gln Gln Ser Leu Leu Thr 
            500                 505                 510         


Leu Gln Gly Thr Leu Gln Pro Glu Pro Pro Gln Asp Ala Arg Phe Gly 
        515                 520                 525             


Phe Ala Met Gly Ala Leu Pro Asp Leu Asn Gln Asp Gly Phe Ala Asp 
    530                 535                 540                 


Val Ala Val Gly Ala Pro Leu Glu Asp Gly His Gln Gly Ala Leu Tyr 
545                 550                 555                 560 


Leu Tyr His Gly Thr Gln Ser Gly Val Arg Pro His Pro Ala Gln Arg 
                565                 570                 575     


Ile Ala Ala Ala Ser Met Pro His Ala Leu Ser Tyr Phe Gly Arg Ser 
            580                 585                 590         


Val Asp Gly Arg Leu Asp Leu Asp Gly Asp Asp Leu Val Asp Val Ala 
        595                 600                 605             


Val Gly Ala Gln Gly Ala Ala Ile Leu Leu Ser Ser Arg Pro Ile Val 
    610                 615                 620                 


His Leu Thr Pro Ser Leu Glu Val Thr Pro Gln Ala Ile Ser Val Val 
625                 630                 635                 640 


Gln Arg Asp Cys Arg Arg Arg Gly Gln Glu Ala Val Cys Leu Thr Ala 
                645                 650                 655     


Ala Leu Cys Phe Gln Val Thr Ser Arg Thr Pro Gly Arg Trp Asp His 
            660                 665                 670         


Gln Phe Tyr Met Arg Phe Thr Ala Ser Leu Asp Glu Trp Thr Ala Gly 
        675                 680                 685             


Ala Arg Ala Ala Phe Asp Gly Ser Gly Gln Arg Leu Ser Pro Arg Arg 
    690                 695                 700                 


Leu Arg Leu Ser Val Gly Asn Val Thr Cys Glu Gln Leu His Phe His 
705                 710                 715                 720 


Val Leu Asp Thr Ser Asp Tyr Leu Arg Pro Val Ala Leu Thr Val Thr 
                725                 730                 735     


Phe Ala Leu Asp Asn Thr Thr Lys Pro Gly Pro Val Leu Asn Glu Gly 
            740                 745                 750         


Ser Pro Thr Ser Ile Gln Lys Leu Val Pro Phe Ser Lys Asp Cys Gly 
        755                 760                 765             


Pro Asp Asn Glu Cys Val Thr Asp Leu Val Leu Gln Val Asn Met Asp 
    770                 775                 780                 


Ile Arg Gly Ser Arg Lys Ala Pro Phe Val Val Arg Gly Gly Arg Arg 
785                 790                 795                 800 


Lys Val Leu Val Ser Thr Thr Leu Glu Asn Arg Lys Glu Asn Ala Tyr 
                805                 810                 815     


Asn Thr Ser Leu Ser Leu Ile Phe Ser Arg Asn Leu His Leu Ala Ser 
            820                 825                 830         


Leu Thr Pro Gln Arg Glu Ser Pro Ile Lys Val Glu Cys Ala Ala Pro 
        835                 840                 845             


Ser Ala His Ala Arg Leu Cys Ser Val Gly His Pro Val Phe Gln Thr 
    850                 855                 860                 


Gly Ala Lys Val Thr Phe Leu Leu Glu Phe Glu Phe Ser Cys Ser Ser 
865                 870                 875                 880 


Leu Leu Ser Gln Val Phe Val Lys Leu Thr Ala Ser Ser Asp Ser Leu 
                885                 890                 895     


Glu Arg Asn Gly Thr Leu Gln Asp Asn Thr Ala Gln Thr Ser Ala Tyr 
            900                 905                 910         


Ile Gln Tyr Glu Pro His Leu Leu Phe Ser Ser Glu Ser Thr Leu His 
        915                 920                 925             


Arg Tyr Glu Val His Pro Tyr Gly Thr Leu Pro Val Gly Pro Gly Pro 
    930                 935                 940                 


Glu Phe Lys Thr Thr Leu Arg Val Gln Asn Leu Gly Cys Tyr Val Val 
945                 950                 955                 960 


Ser Gly Leu Ile Ile Ser Ala Leu Leu Pro Ala Val Ala His Gly Gly 
                965                 970                 975     


Asn Tyr Phe Leu Ser Leu Ser Gln Val Ile Thr Asn Asn Ala Ser Cys 
            980                 985                 990         


Ile Val Gln Asn Leu Thr Glu Pro  Pro Gly Pro Pro Val  His Pro Glu 
        995                 1000                 1005             


Glu Leu  Gln His Thr Asn Arg  Leu Asn Gly Ser Asn  Thr Gln Cys 
    1010                 1015                 1020             


Gln Val  Val Arg Cys His Leu  Gly Gln Leu Ala Lys  Gly Thr Glu 
    1025                 1030                 1035             


Val Ser  Val Gly Leu Leu Arg  Leu Val His Asn Glu  Phe Phe Arg 
    1040                 1045                 1050             


Arg Ala  Lys Phe Lys Ser Leu  Thr Val Val Ser Thr  Phe Glu Leu 
    1055                 1060                 1065             


Gly Thr  Glu Glu Gly Ser Val  Leu Gln Leu Thr Glu  Ala Ser Arg 
    1070                 1075                 1080             


Trp Ser  Glu Ser Leu Leu Glu  Val Val Gln Thr Arg  Pro Ile Leu 
    1085                 1090                 1095             


Ile Ser  
    1100 


<210>  3
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  I-domain of human integrin alpha10

<400>  3

Cys Pro Thr Tyr Met Asp Val Val Ile Val Leu Asp Gly Ser Asn Ser 
1               5                   10                  15      


Ile Tyr Pro Trp Ser Glu Val Gln Thr Phe Leu Arg Arg Leu Val Gly 
            20                  25                  30          


Lys Leu Phe Ile Asp Pro Glu Gln Ile Gln Val Gly Leu Val Gln Tyr 
        35                  40                  45              


Gly Glu Ser Pro Val His Glu Trp Ser Leu Gly Asp Phe Arg Thr Lys 
    50                  55                  60                  


Glu Glu Val Val Arg Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly Arg 
65                  70                  75                  80  


Glu Thr Lys Thr Ala Gln Ala Ile Met Val Ala Cys Thr Glu Gly Phe 
                85                  90                  95      


Ser Gln Ser His Gly Gly Arg Pro Glu Ala Ala Arg Leu Leu Val Val 
            100                 105                 110         


Val Thr Asp Gly Glu Ser His Asp Gly Glu Glu Leu Pro Ala Ala Leu 
        115                 120                 125             


Lys Ala Cys Glu Ala Gly Arg Val Thr Arg Tyr Gly Ile Ala Val Leu 
    130                 135                 140                 


Gly His Tyr Leu Arg Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg Glu 
145                 150                 155                 160 


Ile Arg Thr Ile Ala Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn Val 
                165                 170                 175     


Thr Asp Glu Ala Ala Leu Thr Asp Ile Val Asp Ala Leu Gly Asp Arg 
            180                 185                 190         


Ile Phe Gly Leu Glu Gly 
        195             


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(9)
<223>  Variable heavy chain complementarity-determining region 1 
       (CDR-H1)

<400>  4

Phe Thr Phe Ser Asp Tyr Gly Met Asn 
1               5                   


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(17)
<223>  Variable heavy chain complementarity-determining region 2 
       (CDR-H2)

<400>  5

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(9)
<223>  Variable heavy chain complementarity-determining region 3 
       (CDR-H3)

<400>  6

Gly Gly Asn Trp Gly Val Phe Asp Tyr 
1               5                   


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(13)
<223>  Variable light chain complementarity-determining region 4 
       (CDR-L1)

<400>  7

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val His 
1               5                   10              


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(7)
<223>  Variable light chain complementarity-determining region 5 
       (CDR-L2)

<400>  8

Glu Asn Asn Lys Arg Pro Ser 
1               5           


<210>  9
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(12)
<223>  Variable light chain complementarity-determining region 6 
       (CDR-L3)

<400>  9

Ala Ala Trp Asp Asp Ser Leu Ser Gly Gln Gly Val 
1               5                   10          


<210>  10
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(118)
<223>  Heavy chain variable region

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Trp Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  11
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(112)
<223>  Light chain variable region

<400>  11

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Gln Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


