                         SEQUENCE LISTING

<110>  ProQR Therapeutics II B.V.
       
<120>  ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF USHER SYNDROME

<130>  AC1718 PCT S3

<150>  EP 19 17 0001.2
<151>  2019-04-18

<150>  EP 19 20 3681.2
<151>  2019-10-16

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.1

<400>  1
agggcuuaaa auuucuccug c                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.2

<400>  2
ccaagggcuu aaaauuucuc c                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.3

<400>  3
uuugaaucag aguccaaggg c                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.4

<400>  4
aaguuucuca guccacuugg g                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.5

<400>  5
ccggccauuc ucuuucuguu c                                                 21


<210>  6
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.6

<400>  6
augcccggcc auucucuuuc                                                   20


<210>  7
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.7

<400>  7
ugaccacugu aguagcaaug                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.8

<400>  8
acaccauugg uucucauagg                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.9

<400>  9
augguuugca gccacaacac                                                   20


<210>  10
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.10

<400>  10
ccacaacacc aaugcgauau                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.11

<400>  11
gcaugguuug cagccacaac                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.12

<400>  12
cuuggggaag auucuaaggu                                                   20


<210>  13
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.13

<400>  13
augguucuaa cccguacagg                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.14

<400>  14
ugggcuugau ggcuuguucc                                                   20


<210>  15
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.15

<400>  15
cggccauucu cuuucuguuc uacu                                              24


<210>  16
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.16

<400>  16
auaaaguuuc ucaguccacu uggg                                              24


<210>  17
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.17

<400>  17
gauggcuugu ucccuguaag                                                   20


<210>  18
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.18

<400>  18
ggcuuguucc cuguaagaaa                                                   20


<210>  19
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.19

<400>  19
guucccugua agaaaauuaa cagg                                              24


<210>  20
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.20

<400>  20
gguagacauu accuuaauca cacc                                              24


<210>  21
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.21

<400>  21
gcaggguaga cauuaccuua auc                                               23


<210>  22
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.22

<400>  22
gacauuaccu uaaucacacc auug                                              24


<210>  23
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  23
aaaaaaaaaa aacaacaact taacctgtta attttcttac agggaacaag ccatcaagcc       60

cacctgtacg ggttagaacc attcacaaca tatcgcattg gtgttgtggc tgcaaaccat      120

gcaggagaaa ttttaagccc ttggactctg attcaaacct tagaatcttc cccaagtgga      180

ctgagaaact ttatagtaga acagaaagag aatggccggg cattgctact acagtggtca      240

gaacctatga gaaccaatgg tgtgattaag gtaatgtcta ccctgcataa gaaa            294


<210>  24
<211>  228
<212>  DNA
<213>  Homo sapiens

<400>  24
ggaacaagcc atcaagccca cctgtacggg ttagaaccat tcacaacata tcgcattggt       60

gttgtggctg caaaccatgc aggagaaatt ttaagccctt ggactctgat tcaaacctta      120

gaatcttccc caagtggact gagaaacttt atagtagaac agaaagagaa tggccgggca      180

ttgctactac agtggtcaga acctatgaga accaatggtg tgattaag                   228


<210>  25
<211>  294
<212>  RNA
<213>  Homo sapiens

<400>  25
aaaaaaaaaa aacaacaacu uaaccuguua auuuucuuac agggaacaag ccaucaagcc       60

caccuguacg gguuagaacc auucacaaca uaucgcauug guguuguggc ugcaaaccau      120

gcaggagaaa uuuuaagccc uuggacucug auucaaaccu uagaaucuuc cccaagugga      180

cugagaaacu uuauaguaga acagaaagag aauggccggg cauugcuacu acagugguca      240

gaaccuauga gaaccaaugg ugugauuaag guaaugucua cccugcauaa gaaa            294


<210>  26
<211>  228
<212>  RNA
<213>  Homo sapiens

<400>  26
ggaacaagcc aucaagccca ccuguacggg uuagaaccau ucacaacaua ucgcauuggu       60

guuguggcug caaaccaugc aggagaaauu uuaagcccuu ggacucugau ucaaaccuua      120

gaaucuuccc caaguggacu gagaaacuuu auaguagaac agaaagagaa uggccgggca      180

uugcuacuac aguggucaga accuaugaga accaauggug ugauuaag                   228


<210>  27
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ddPCR forward primer

<400>  27
gacccgacga tcctacat                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ddPCR reverse primer

<400>  28
gcggaagaga aactgacg                                                     18


<210>  29
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  exon 62 FAM probe

<400>  29
cacagtgaag acatacaaca tcttcagtga cgg                                    33


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ddPCR forward primer

<400>  30
cagatttgct gtgctgggag                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ddPCR reverse primer

<400>  31
ttcacataat cctgcccaca                                                   20


<210>  32
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  exon 50 HEX probe

<400>  32
catacctgga aggcgattgt acaccactc                                         29


<210>  33
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.23

<400>  33
ggcuuguucc cuguaagaaa auu                                               23


<210>  34
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.24

<400>  34
gauggcuugu ucccuguaag aaa                                               23


<210>  35
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.25

<400>  35
cuugauggcu uguucccugu aag                                               23


<210>  36
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.26

<400>  36
guucuaaccc guacaggugg gcuu                                              24


<210>  37
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.27

<400>  37
augguucuaa cccguacagg uggg                                              24


<210>  38
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.28

<400>  38
gugaaugguu cuaacccgua cagg                                              24


<210>  39
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.29

<400>  39
guugugaaug guucuaaccc guac                                              24


<210>  40
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.30

<400>  40
accuuaauca caccauuggu ucuc                                              24


<210>  41
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.31

<400>  41
uuaugcaggg uagacauuac cuu                                               23


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.32

<400>  42
ggcuuguucc cuguaagaa                                                    19


<210>  43
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.33

<400>  43
ggcuuguucc cuguaaga                                                     18


<210>  44
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.34

<400>  44
gcuuguuccc uguaaga                                                      17


<210>  45
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.35

<400>  45
gcuuguuccc uguaag                                                       16


<210>  46
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.36

<400>  46
ggcuuguucc cuguaag                                                      17


<210>  47
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.37

<400>  47
uggcuuguuc ccuguaag                                                     18


<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.38

<400>  48
auggcuuguu cccuguaag                                                    19


<210>  49
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.39

<400>  49
ugugaauggu ucuaacccgu ac                                                22


<210>  50
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.40

<400>  50
gugaaugguu cuaacccgua c                                                 21


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.41

<400>  51
gaaugguucu aacccguac                                                    19


<210>  52
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.42

<400>  52
aaugguucua acccguac                                                     18


<210>  53
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.43

<400>  53
augguucuaa cccguac                                                      17


<210>  54
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.44

<400>  54
guugugaaug guucuaaccc gu                                                22


<210>  55
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.45

<400>  55
guugugaaug guucuaaccc                                                   20


<210>  56
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.46

<400>  56
guugugaaug guucuaac                                                     18


<210>  57
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.47

<400>  57
guugugaaug guucua                                                       16


<210>  58
<211>  14
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.48

<400>  58
guugugaaug guuc                                                         14


<210>  59
<211>  274
<212>  DNA
<213>  Homo sapiens

<400>  59
taacctgtta attttcttac agggaacaag ccatcaagcc cacctgtacg ggttagaacc       60

attcacaaca tatcgcattg gtgttgtggc tgcaaaccat gcaggagaaa ttttaagccc      120

ttggactctg attcaaacct tagaatcttc cccaagtgga ctgagaaact ttatagtaga      180

acagaaagag aatggccggg cattgctact acagtggtca gaacctatga gaaccaatgg      240

tgtgattaag gtaatgtcta ccctgcataa gaaa                                  274


<210>  60
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.49

<400>  60
guugugaaug guucuaa                                                      17


<210>  61
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.50

<400>  61
guugugaaug guucuaaccc g                                                 21


<210>  62
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.51

<400>  62
guugugaaug guucuaacc                                                    19


<210>  63
<211>  15
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AON Ex62.52

<400>  63
guugugaaug guucu                                                        15


