                         SEQUENCE LISTING

<110>  ICHILOV TECH LTD.
       YEDA RESEARCH AND DEVELOPMENT CO. LTD
 
<120>  EXTRACELLULAR VESICLES DERIVED FROM ACTIVATED CAR-T CELLS

<130>  SMC-017 PCT

<150>  IL266153
<151>  2019-04-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  1

Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg 
1               5                   10                  15      


Ile Ser Val Thr Cys Lys Ala Ser Gln Asp Val Gly Pro Asn Val Ala 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser 
        35                  40                  45              


Ala Ser Tyr Leu Tyr Asn Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Val Gln Ser Asp Asp 
65                  70                  75                  80  


Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Phe Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  2
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  2

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Val Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Thr Ser Tyr Tyr Asp Tyr Asp Lys Val Leu Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Lys Gly 
        115                 120             


<210>  3
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Val Met Thr Gln Ser Pro Lys Phe 
            20                  25                  30          


Met Ser Thr Ser Val Gly Asp Arg Ile Ser Val Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Pro Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Pro Leu Ile Tyr Ser Ala Ser Tyr Leu Tyr Tyr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Val Gln Ser Asp Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
            100                 105                 110         


Tyr Asn Thr Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu 
    130                 135                 140                 


Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly Ser 
145                 150                 155                 160 


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 
                165                 170                 175     


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Val 
            180                 185                 190         


Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp Ser 
        195                 200                 205             


Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met Leu 
    210                 215                 220                 


Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Val Thr Ser Tyr Tyr Asp Tyr Asp Lys Val Leu Phe Ala Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Lys Gly Lys His Leu Cys Pro Ser 
            260                 265                 270         


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
        275                 280                 285             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gln Val Arg 
            340                 345                 350         


Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly 
        355                 360                 365             


Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys 
    370                 375                 380                 


Pro Pro Gln 
385         


<210>  4
<211>  1177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  4
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agaggagata ttgtgatgac ccagtctcca aaattcatgt ccacatcagt aggagacagg      120

atcagcgtca cctgcaaggc cagtcaagat gtgggtccta atgtagcctg gtatcaacag      180

aaaccagggc aatctcctaa accactgatt tactcggcat cctacctata ttatggagtc      240

cctgatcgct tcacaggcag tggatctggg acagatttct ctctcaccat cagcaatgtg      300

cagtctgatg acttggcaga gtatttctgt cagcaatata acacctatcc gttcacgttc      360

ggagggggca ccaagctgga aatcaaaggg tcgacttccg gtagcggcaa atcctctgaa      420

ggcaaaggtg aggtgcagct ggaggagtct ggtggaggat tggtgcagcc taaagggtca      480

ttgaaactct catgtgcagc ctctggattc accttcaata cctacgccat gaactgggtc      540

cgccaggctc caggaaaggg tttggaatgg attgttcgca taagaagtaa aagtaataat      600

tatgcaacat attatgtcga ttcagtgaaa gacaggttca ccatctccag agatgattca      660

caaagcatgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      720

tgtgtgactt cttactatga ttacgacaag gtcctgtttg cttactgggg ccaaggaact      780

acggtcaccg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      840

cccttttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca      900

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac      960

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     1020

ccacgcgact tcgcagccta tagatctcaa gtgcgaaagg cagctataac cagctatgag     1080

aaatcagatg gtgtttacac gggcctgagc accaggaacc aggagactta cgagactctg     1140

aagcatgaga aaccaccaca gtagctttag actcgag                              1177


