                               SEQUENCE LISTING

<110> ALLOGENE THERAPEUTICS, INC.
 
<120> ANTIBODIES AGAINST 4G7-DERIVED CHIMERIC ANTIGEN RECEPTORS

<130> AT-020/02WO

<140>
<141>

<150> 62/836,242
<151> 2019-04-19

<160> 45    

<170> PatentIn version 3.5

<210> 1
<211> 120
<212> PRT
<213> Mus musculus

<400> 1
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Tyr Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asn Asp Tyr Asp Leu Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210> 2
<211> 118
<212> PRT
<213> Mus musculus

<400> 2
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210> 3
<211> 118
<212> PRT
<213> Mus musculus

<400> 3
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Thr Pro Gly Ser Gly Gly Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210> 4
<211> 360
<212> DNA
<213> Mus musculus

<400> 4
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaaggtg       60

tcctgcaagg cttttggcta caccttcact acctatccaa tagagtggat gaggcagaat      120

catggaaaga gcctagagtg gattggaaat tttcatcctt acaatgatga tactaggtac      180

aatgaaaaat tcaaggacaa ggccaaattg actgtagaaa aatcctctag cacagtctac      240

ttggagctca gccgattaac atatgatgac tctgctgttt attactgtac aagggggaat      300

gattacgacc tctatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210> 5
<211> 354
<212> DNA
<213> Mus musculus

<400> 5
caggtccagc tgcagcagtc tggagctgaa ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattatttga tagagtggat aaagcagagg      120

cctggacagg gccttgagtg gattggagtg attaatcctg gaagtggtgg tattaattat      180

aatgagaagt tcaagggcaa ggcaacactg acttcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggtct atttctgtgc aagatggctt      300

gattacgact ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210> 6
<211> 354
<212> DNA
<213> Mus musculus

<400> 6
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cctctgggta cgccttcact aattatttga tagagtgggt aaagcagagg      120

cctggacagg gcctagagtg gattggagtg attactcctg gaagtggcgg ttctaactac      180

aatgagaagt tcaagggcaa ggcaacactg actgcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggtct acttctgtgc aagatggctt      300

gattacgact ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210> 7
<211> 107
<212> PRT
<213> Mus musculus

<400> 7
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Cys Asp Asp Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 8
<211> 107
<212> PRT
<213> Mus musculus

<400> 8
Asp Ile Lys Met Thr Gln Phe Pro Ser Ser Met Tyr Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Cys Asp Glu Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 9
<211> 107
<212> PRT
<213> Mus musculus

<400> 9
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Arg Gln Cys Asp Glu Phe Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 10
<211> 107
<212> PRT
<213> Mus musculus

<400> 10
Asp Ile Lys Met Thr Gln Phe Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Cys Asp Asp Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 11
<211> 321
<212> DNA
<213> Mus musculus

<400> 11
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat acctatttaa cctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tgtgatgatt ttccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210> 12
<211> 321
<212> DNA
<213> Mus musculus

<400> 12
gacatcaaga tgacccagtt tccatcttcc atgtatgcat ctgtaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatttatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tgtgatgagt ttccgttcac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210> 13
<211> 321
<212> DNA
<213> Mus musculus

<400> 13
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtcgacag tgtgatgagt ttccgtccac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210> 14
<211> 321
<212> DNA
<213> Mus musculus

<400> 14
gacatcaaga tgacccagtt tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat acctatttaa cctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tgtgatgatt ttccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210> 15
<211> 7
<212> PRT
<213> Mus musculus

<400> 15
Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210> 16
<211> 6
<212> PRT
<213> Mus musculus

<400> 16
His Pro Tyr Asn Asp Asp 
1               5       


<210> 17
<211> 11
<212> PRT
<213> Mus musculus

<400> 17
Gly Asn Asp Tyr Asp Leu Tyr Gly Met Asp Tyr 
1               5                   10      


<210> 18
<211> 11
<212> PRT
<213> Mus musculus

<400> 18
Lys Ala Ser Gln Asp Ile Asn Thr Tyr Leu Thr 
1               5                   10      


<210> 19
<211> 7
<212> PRT
<213> Mus musculus

<400> 19
Arg Ala Asn Arg Leu Val Asp 
1               5           


<210> 20
<211> 9
<212> PRT
<213> Mus musculus

<400> 20
Leu Gln Cys Asp Asp Phe Pro Leu Thr 
1               5                   


<210> 21
<211> 5
<212> PRT
<213> Mus musculus

<400> 21
Thr Tyr Pro Ile Glu 
1               5   


<210> 22
<211> 17
<212> PRT
<213> Mus musculus

<400> 22
Asn Phe His Pro Tyr Asn Asp Asp Thr Arg Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 23
<211> 11
<212> PRT
<213> Mus musculus

<400> 23
Gly Asn Asp Tyr Asp Leu Tyr Gly Met Asp Tyr 
1               5                   10      


<210> 24
<211> 7
<212> PRT
<213> Mus musculus

<400> 24
Gly Tyr Ala Phe Thr Asn Tyr 
1               5           


<210> 25
<211> 6
<212> PRT
<213> Mus musculus

<400> 25
Asn Pro Gly Ser Gly Gly 
1               5       


<210> 26
<211> 9
<212> PRT
<213> Mus musculus

<400> 26
Trp Leu Asp Tyr Asp Trp Phe Ala Tyr 
1               5                   


<210> 27
<211> 11
<212> PRT
<213> Mus musculus

<400> 27
Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210> 28
<211> 9
<212> PRT
<213> Mus musculus

<400> 28
Leu Gln Cys Asp Glu Phe Pro Phe Thr 
1               5                   


<210> 29
<211> 5
<212> PRT
<213> Mus musculus

<400> 29
Asn Tyr Leu Ile Glu 
1               5   


<210> 30
<211> 17
<212> PRT
<213> Mus musculus

<400> 30
Val Ile Asn Pro Gly Ser Gly Gly Ile Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 31
<211> 6
<212> PRT
<213> Mus musculus

<400> 31
Thr Pro Gly Ser Gly Gly 
1               5       


<210> 32
<211> 9
<212> PRT
<213> Mus musculus

<400> 32
Arg Gln Cys Asp Glu Phe Pro Ser Thr 
1               5                   


<210> 33
<211> 17
<212> PRT
<213> Mus musculus

<400> 33
Val Ile Thr Pro Gly Ser Gly Gly Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 34
<211> 464
<212> PRT
<213> Mus musculus

<400> 34
Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210> 35
<211> 239
<212> PRT
<213> Mus musculus

<400> 35
Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210> 36
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     


Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         


Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val 
    210                 215                 220                 


Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys 
                245             


<210> 37
<211> 1392
<212> DNA
<213> Mus musculus

<400> 37
atggcgtgga tctctatcat cctcttccta gtggcaacag ctataggtgt ccactcccag       60

gttcagctgc agcagtctgg ggctgagctg gtgaagcctg gggcctcagt gaaggtgtcc      120

tgcaaggctt ttggctacac cttcactacc tatccaatag agtggatgag gcagaatcat      180

ggaaagagcc tagagtggat tggaaatttt catccttaca atgatgatac taggtacaat      240

gaaaaattca aggacaaggc caaattgact gtagaaaaat cctctagcac agtctacttg      300

gagctcagcc gattaacata tgatgactct gctgtttatt actgtacaag ggggaatgat      360

tacgacctct atggtatgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc      420

aaaacgacac ccccatctgt ctatccactg gcccctggat ctgctgccca aactaactcc      480

atggtgaccc tgggatgcct ggtcaagggc tatttccctg agccagtgac agtgacctgg      540

aactctggat ccctgtccag cggtgtgcac accttcccag ctgtcctgca gtctgacctc      600

tacactctga gcagctcagt gactgtcccc tccagcacct ggcccagcga gaccgtcacc      660

tgcaacgttg cccacccggc cagcagcacc aaggtggaca agaaaattgt gcccagggat      720

tgtggttgta agccttgcat atgtacagtc ccagaagtat catctgtctt catcttcccc      780

ccaaagccca aggatgtgct caccattact ctgactccta aggtcacgtg tgttgtggta      840

gacatcagca aggatgatcc cgaggtccag ttcagctggt ttgtagatga tgtggaggtg      900

cacacagctc agacgcaacc ccgggaggag cagttcaaca gcactttccg ctcagtcagt      960

gaacttccca tcatgcacca ggactggctc aatggcaagg agttcaaatg cagggtcaac     1020

agtgcagctt tccctgcccc catcgagaaa accatctcca aaaccaaagg cagaccgaag     1080

gctccacagg tgtacaccat tccacctccc aaggagcaga tggccaagga taaagtcagt     1140

ctgacctgca tgataacaga cttcttccct gaagacatta ctgtggagtg gcagtggaat     1200

gggcagccag cggagaacta caagaacact cagcccatca tggacacaga tggctcttac     1260

ttcgtctaca gcaagctcaa tgtgcagaag agcaactggg aggcaggaaa tactttcacc     1320

tgctctgtgt tacatgaggg cctgcacaac caccatactg agaagagcct ctcccactct     1380

cctggtaaat ga                                                         1392


<210> 38
<211> 463
<212> PRT
<213> Mus musculus

<400> 38
Met Ala Trp Ile Ser Ile Ile Leu Phe Leu Val Ala Thr Ala Ile Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Met Arg Gln Asn His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Arg Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asp Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Leu Glu Leu Ser Arg Leu Thr Tyr Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asn Asp Tyr Asp Leu Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
            260                 265                 270         


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
305                 310                 315                 320 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
        355                 360                 365             


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
    370                 375                 380                 


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
385                 390                 395                 400 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
                405                 410                 415     


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
            420                 425                 430         


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460             


<210> 39
<211> 444
<212> PRT
<213> Mus musculus

<400> 39
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Tyr Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asn Asp Tyr Asp Leu Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210> 40
<211> 705
<212> DNA
<213> Mus musculus

<400> 40
atgaggaccc ctgctcagtt tcttggaatc ttgttgctct ggtttccagg tatcaaatgt       60

gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      120

atcacttgca aggcgagtca ggacattaat acctatttaa cctggttcca gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      300

gaagatatgg gaatttatta ttgtctacag tgtgatgatt ttccgctcac gttcggtgct      360

gggaccaagc tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210> 41
<211> 234
<212> PRT
<213> Mus musculus

<400> 41
Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Thr Tyr Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Cys Asp 
            100                 105                 110         


Asp Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210> 42
<211> 214
<212> PRT
<213> Mus musculus

<400> 42
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Cys Asp Asp Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210> 43
<211> 237
<212> PRT
<213> Mus musculus

<400> 43
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
225                 230                 235         


<210> 44
<211> 112
<212> PRT
<213> Mus musculus

<400> 44
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      8xHis tag"

<400> 45
His His His His His His His His 
1               5               


