                         б

<110>  Ž
 
<120>  һֵʷӼ;

<130>  0069-PA-011

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  469
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaL19

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
        115                 120                 125             


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
    130                 135                 140                 


Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr 
                165                 170                 175     


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            180                 185                 190         


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
        195                 200                 205             


Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
    210                 215                 220                 


Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
225                 230                 235                 240 


Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            260                 265                 270         


Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp 
    290                 295                 300                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            340                 345                 350         


Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
        355                 360                 365             


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
    370                 375                 380                 


Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln 
385                 390                 395                 400 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg 
                405                 410                 415     


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            420                 425                 430         


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
        435                 440                 445             


Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr 
    450                 455                 460                 


Lys Val Glu Ile Lys 
465                 


<210>  2
<211>  477
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaF8

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
                165                 170                 175     


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
305                 310                 315                 320 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
        355                 360                 365             


Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met 
385                 390                 395                 400 


Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
                405                 410                 415     


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
            420                 425                 430         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
        435                 440                 445             


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg 
    450                 455                 460                 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
465                 470                 475         


<210>  3
<211>  475
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaNHS76

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln 
        115                 120                 125             


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
    130                 135                 140                 


Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys 
145                 150                 155                 160 


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro 
                165                 170                 175     


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
            180                 185                 190         


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
        195                 200                 205             


Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly 
    210                 215                 220                 


Thr Lys Leu Thr Val Leu Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
225                 230                 235                 240 


Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
                245                 250                 255     


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr 
            260                 265                 270         


Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr 
    290                 295                 300                 


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
305                 310                 315                 320 


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
        355                 360                 365             


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
    370                 375                 380                 


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
                405                 410                 415     


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
            420                 425                 430         


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
        435                 440                 445             


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
    450                 455                 460                 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
465                 470                 475 


<210>  4
<211>  476
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaNHS76F8

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln 
        115                 120                 125             


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
    130                 135                 140                 


Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln 
145                 150                 155                 160 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
                165                 170                 175     


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
225                 230                 235                 240 


Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            260                 265                 270         


Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
305                 310                 315                 320 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr 
            340                 345                 350         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
    370                 375                 380                 


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
385                 390                 395                 400 


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
                405                 410                 415     


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            420                 425                 430         


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
        435                 440                 445             


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
    450                 455                 460                 


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
465                 470                 475     


<210>  5
<211>  472
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaNHS76L19

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln 
        115                 120                 125             


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
    130                 135                 140                 


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln 
145                 150                 155                 160 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser 
                165                 170                 175     


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
225                 230                 235                 240 


Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            260                 265                 270         


Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
305                 310                 315                 320 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly 
            340                 345                 350         


Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Ser Ser Glu Leu 
        355                 360                 365             


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile 
    370                 375                 380                 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
385                 390                 395                 400 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
                405                 410                 415     


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
            420                 425                 430         


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
        435                 440                 445             


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly 
    450                 455                 460                 


Gly Gly Thr Lys Leu Thr Val Leu 
465                 470         


<210>  6
<211>  476
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaF8NHS76

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr 
        115                 120                 125             


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
    130                 135                 140                 


Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln 
145                 150                 155                 160 


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg 
                165                 170                 175     


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
            180                 185                 190         


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
        195                 200                 205             


Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Thr Val Leu Ser Ser Ser Ser Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Gly Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
                245                 250                 255     


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
            260                 265                 270         


Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr 
    290                 295                 300                 


Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
305                 310                 315                 320 


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr 
            340                 345                 350         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        355                 360                 365             


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro 
385                 390                 395                 400 


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                405                 410                 415     


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
        435                 440                 445             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro 
    450                 455                 460                 


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
465                 470                 475     


<210>  7
<211>  473
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaF8L19

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser 
                165                 170                 175     


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
305                 310                 315                 320 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile Val 
        355                 360                 365             


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    370                 375                 380                 


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
                405                 410                 415     


Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
        435                 440                 445             


Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe 
    450                 455                 460                 


Gly Gln Gly Thr Lys Val Glu Ile Lys 
465                 470             


<210>  8
<211>  472
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaL19NHS76

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala 
        115                 120                 125             


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
    130                 135                 140                 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
145                 150                 155                 160 


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
                165                 170                 175     


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
            180                 185                 190         


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
        195                 200                 205             


Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Thr Val Leu Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
225                 230                 235                 240 


Ser Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
                245                 250                 255     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
            260                 265                 270         


Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
        275                 280                 285             


Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro 
    290                 295                 300                 


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
305                 310                 315                 320 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly 
            340                 345                 350         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu 
        355                 360                 365             


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
    370                 375                 380                 


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp 
385                 390                 395                 400 


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala 
                405                 410                 415     


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
            420                 425                 430         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
        435                 440                 445             


Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly 
    450                 455                 460                 


Gln Gly Thr Lys Val Glu Ile Lys 
465                 470         


<210>  9
<211>  473
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  DiaL19F8

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
        115                 120                 125             


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
    130                 135                 140                 


Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
                165                 170                 175     


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            180                 185                 190         


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
        195                 200                 205             


Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
    210                 215                 220                 


Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
225                 230                 235                 240 


Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            260                 265                 270         


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
    290                 295                 300                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln 
            340                 345                 350         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val 
        355                 360                 365             


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    370                 375                 380                 


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 
385                 390                 395                 400 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr 
                405                 410                 415     


Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
        435                 440                 445             


Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe 
    450                 455                 460                 


Gly Gln Gly Thr Lys Val Glu Ile Lys 
465                 470             


<210>  10
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L19VL

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L19VH

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val 
        


<210>  12
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F8VL

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  13
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F8VH

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  14
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NHS76VL

<400>  14

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  15
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NHS76VH

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210>  17
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  18
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  19
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  20
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  21
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  22
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ile His Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu 
            20                  25                  30          


Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser 
        35                  40                  45              


Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu 
65                  70                  75                  80  


Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn 
                85                  90                  95      


Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210>  23
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210>  24
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser Asn 
            20                  25                  30          


Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp Asp 
        35                  40                  45              


Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys Gln 
    50                  55                  60                  


Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu Thr 
65                  70                  75                  80  


Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu Glu 
                85                  90                  95      


Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys Arg 
            100                 105                 110         


Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly Ser 
        115                 120                 125             


Ile 
    


<210>  25
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  26
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  26

His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
        35                  40                  45              


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
    50                  55                  60                  


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
65                  70                  75                  80  


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
                85                  90                  95      


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser 
    


<210>  27
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210>  28
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Thr Pro Asp Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe 
1               5                   10                  15      


Lys Val Lys Phe Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro 
            20                  25                  30          


Val Thr Val Ala Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu 
        35                  40                  45              


Trp Ser Leu Phe Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val 
    50                  55                  60                  


Ala Gly Ser Lys Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile 
65                  70                  75                  80  


His Phe Val Thr Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg 
                85                  90                  95      


Phe Val Gln Thr Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln 
            100                 105                 110         


Leu Leu Ala Leu Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser 
        115                 120                 125             


Arg Cys Leu Glu Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro 
    130                 135                 140                 


Pro Arg Ser Pro Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg 
145                 150                 155                 160 


Pro Arg Gln Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu 
                165                 170                 175     


Val Leu Leu Ala Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg 
            180                 185                 190         


Arg Gly Glu Leu His Pro Gly Val Pro Leu Pro Ser His Pro 
        195                 200                 205     


<210>  29
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala 
                165                 170                 175     


Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly 
            180                 185                 190         


Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu 
        195                 200                 205             


His 
    


<210>  30
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
        115                 120                 


<210>  31
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  32
<211>  824
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSF

<400>  32

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg 
    690                 695                 700                 


Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys 
705                 710                 715                 720 


Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu 
                725                 730                 735     


Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val 
            740                 745                 750         


Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr 
        755                 760                 765             


Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr 
    770                 775                 780                 


Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr 
785                 790                 795                 800 


Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe 
                805                 810                 815     


Glu Cys Lys Lys Pro Gly Gln Lys 
            820                 


<210>  33
<211>  804
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL7GMCSF

<400>  33

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Cys His Ile Lys Asp Lys Glu 
    530                 535                 540                 


Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu Asp 
545                 550                 555                 560 


Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn Phe 
                565                 570                 575     


Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu Asn 
            580                 585                 590         


Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser Glu 
        595                 600                 605             


Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr Leu 
    610                 615                 620                 


Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys Lys 
625                 630                 635                 640 


Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr Cys 
                645                 650                 655     


Trp Asn Lys Ile Leu Lys Gly Ser Ile Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile Thr 
        675                 680                 685             


Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn 
    690                 695                 700                 


Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val 
705                 710                 715                 720 


Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu 
                725                 730                 735     


Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly 
            740                 745                 750         


Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr 
        755                 760                 765             


Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile 
    770                 775                 780                 


Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys 
785                 790                 795                 800 


Pro Gly Gln Lys 
                


<210>  34
<211>  808
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL15GMCSF

<400>  34

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala Asn Trp Ile Asp Val 
545                 550                 555                 560 


Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile 
                565                 570                 575     


Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu 
        595                 600                 605             


Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu 
    610                 615                 620                 


Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg 
        675                 680                 685             


Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys 
    690                 695                 700                 


Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu 
705                 710                 715                 720 


Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val 
                725                 730                 735     


Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr 
            740                 745                 750         


Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr 
        755                 760                 765             


Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr 
    770                 775                 780                 


Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe 
785                 790                 795                 800 


Glu Cys Lys Lys Pro Gly Gln Lys 
                805             


<210>  35
<211>  804
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL21GMCSF

<400>  35

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Pro Gln Gly Pro 
    530                 535                 540                 


Asp Arg Leu Leu Ile Arg Leu Arg His Leu Ile Asp Ile Val Glu Gln 
545                 550                 555                 560 


Leu Lys Ile Tyr Glu Asn Asp Leu Asp Pro Glu Leu Leu Ser Ala Pro 
                565                 570                 575     


Gln Asp Val Lys Gly His Cys Glu His Ala Ala Phe Ala Cys Phe Gln 
            580                 585                 590         


Lys Ala Lys Leu Lys Pro Ser Asn Pro Gly Asn Asn Lys Thr Phe Ile 
        595                 600                 605             


Ile Asp Leu Val Ala Gln Leu Arg Arg Arg Leu Pro Ala Arg Arg Gly 
    610                 615                 620                 


Gly Lys Lys Gln Lys His Ile Ala Lys Cys Pro Ser Cys Asp Ser Tyr 
625                 630                 635                 640 


Glu Lys Arg Thr Pro Lys Glu Phe Leu Glu Arg Leu Lys Trp Leu Leu 
                645                 650                 655     


Gln Lys Met Ile His Gln His Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile Thr 
        675                 680                 685             


Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn 
    690                 695                 700                 


Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val 
705                 710                 715                 720 


Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu 
                725                 730                 735     


Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly 
            740                 745                 750         


Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr 
        755                 760                 765             


Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile 
    770                 775                 780                 


Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys 
785                 790                 795                 800 


Pro Gly Gln Lys 
                


<210>  36
<211>  906
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2FLT3L

<400>  36

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp 
    690                 695                 700                 


Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe 
705                 710                 715                 720 


Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala 
                725                 730                 735     


Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe 
            740                 745                 750         


Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys 
        755                 760                 765             


Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr 
    770                 775                 780                 


Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr 
785                 790                 795                 800 


Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu 
                805                 810                 815     


Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu 
            820                 825                 830         


Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro 
        835                 840                 845             


Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu 
    850                 855                 860                 


Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala 
865                 870                 875                 880 


Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu 
                885                 890                 895     


His Pro Gly Val Pro Leu Pro Ser His Pro 
            900                 905     


<210>  37
<211>  886
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL7FLT3L

<400>  37

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Cys His Ile Lys Asp Lys Glu 
    530                 535                 540                 


Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu Asp 
545                 550                 555                 560 


Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn Phe 
                565                 570                 575     


Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu Asn 
            580                 585                 590         


Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser Glu 
        595                 600                 605             


Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr Leu 
    610                 615                 620                 


Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys Lys 
625                 630                 635                 640 


Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr Cys 
                645                 650                 655     


Trp Asn Lys Ile Leu Lys Gly Ser Ile Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp Cys Tyr Phe Ser 
        675                 680                 685             


His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu Leu Thr 
    690                 695                 700                 


Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn Leu Gln 
705                 710                 715                 720 


Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala Gln Arg 
                725                 730                 735     


Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln Thr Leu 
            740                 745                 750         


Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys Thr Phe 
        755                 760                 765             


Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile Ser His 
    770                 775                 780                 


Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro Cys Ile 
785                 790                 795                 800 


Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln Cys Gln 
                805                 810                 815     


Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala Leu Glu 
            820                 825                 830         


Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu Leu Leu 
        835                 840                 845             


Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala Trp Gly 
    850                 855                 860                 


Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro Gly Val 
865                 870                 875                 880 


Pro Leu Pro Ser His Pro 
                885     


<210>  38
<211>  890
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL15FLT3L

<400>  38

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala Asn Trp Ile Asp Val 
545                 550                 555                 560 


Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile 
                565                 570                 575     


Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu 
        595                 600                 605             


Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu 
    610                 615                 620                 


Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp 
        675                 680                 685             


Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe 
    690                 695                 700                 


Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala 
705                 710                 715                 720 


Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe 
                725                 730                 735     


Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys 
            740                 745                 750         


Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr 
        755                 760                 765             


Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr 
    770                 775                 780                 


Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu 
785                 790                 795                 800 


Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu 
                805                 810                 815     


Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro 
            820                 825                 830         


Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu 
        835                 840                 845             


Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala 
    850                 855                 860                 


Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu 
865                 870                 875                 880 


His Pro Gly Val Pro Leu Pro Ser His Pro 
                885                 890 


<210>  39
<211>  886
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL21FLT3L

<400>  39

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Pro Gln Gly Pro 
    530                 535                 540                 


Asp Arg Leu Leu Ile Arg Leu Arg His Leu Ile Asp Ile Val Glu Gln 
545                 550                 555                 560 


Leu Lys Ile Tyr Glu Asn Asp Leu Asp Pro Glu Leu Leu Ser Ala Pro 
                565                 570                 575     


Gln Asp Val Lys Gly His Cys Glu His Ala Ala Phe Ala Cys Phe Gln 
            580                 585                 590         


Lys Ala Lys Leu Lys Pro Ser Asn Pro Gly Asn Asn Lys Thr Phe Ile 
        595                 600                 605             


Ile Asp Leu Val Ala Gln Leu Arg Arg Arg Leu Pro Ala Arg Arg Gly 
    610                 615                 620                 


Gly Lys Lys Gln Lys His Ile Ala Lys Cys Pro Ser Cys Asp Ser Tyr 
625                 630                 635                 640 


Glu Lys Arg Thr Pro Lys Glu Phe Leu Glu Arg Leu Lys Trp Leu Leu 
                645                 650                 655     


Gln Lys Met Ile His Gln His Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp Cys Tyr Phe Ser 
        675                 680                 685             


His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu Leu Thr 
    690                 695                 700                 


Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn Leu Gln 
705                 710                 715                 720 


Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala Gln Arg 
                725                 730                 735     


Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln Thr Leu 
            740                 745                 750         


Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys Thr Phe 
        755                 760                 765             


Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile Ser His 
    770                 775                 780                 


Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro Cys Ile 
785                 790                 795                 800 


Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln Cys Gln 
                805                 810                 815     


Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala Leu Glu 
            820                 825                 830         


Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu Leu Leu 
        835                 840                 845             


Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala Trp Gly 
    850                 855                 860                 


Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro Gly Val 
865                 870                 875                 880 


Pro Leu Pro Ser His Pro 
                885     


<210>  40
<211>  824
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aGMCSFIL2

<400>  40

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile Thr 
    530                 535                 540                 


Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn 
545                 550                 555                 560 


Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val 
                565                 570                 575     


Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu 
            580                 585                 590         


Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly 
        595                 600                 605             


Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr 
    610                 615                 620                 


Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile 
625                 630                 635                 640 


Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys 
                645                 650                 655     


Pro Gly Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu 
        675                 680                 685             


Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu 
    690                 695                 700                 


Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr 
705                 710                 715                 720 


Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro 
                725                 730                 735     


Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu 
            740                 745                 750         


Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln 
        755                 760                 765             


Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val 
    770                 775                 780                 


Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu 
785                 790                 795                 800 


Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln 
                805                 810                 815     


Ser Ile Ile Ser Thr Ser Pro Gln 
            820                 


<210>  41
<211>  808
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2GMCSF

<400>  41

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
    530                 535                 540                 


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
545                 550                 555                 560 


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
                565                 570                 575     


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
            580                 585                 590         


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
        595                 600                 605             


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
    610                 615                 620                 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
625                 630                 635                 640 


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
                645                 650                 655     


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro Ser 
        675                 680                 685             


Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg 
    690                 695                 700                 


Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr 
705                 710                 715                 720 


Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu 
                725                 730                 735     


Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr 
            740                 745                 750         


Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His 
        755                 760                 765             


Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe 
    770                 775                 780                 


Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe 
785                 790                 795                 800 


Asp Cys Trp Glu Pro Val Gln Glu 
                805             


<210>  42
<211>  827
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL7GMCSF

<400>  42

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln 
    530                 535                 540                 


Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met 
545                 550                 555                 560 


Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys 
                565                 570                 575     


Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala 
            580                 585                 590         


Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe 
        595                 600                 605             


Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn 
    610                 615                 620                 


Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala 
625                 630                 635                 640 


Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys 
                645                 650                 655     


Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys 
            660                 665                 670         


Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg 
    690                 695                 700                 


Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln 
705                 710                 715                 720 


Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met 
                725                 730                 735     


Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro 
            740                 745                 750         


Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly 
        755                 760                 765             


Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr 
    770                 775                 780                 


Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile 
785                 790                 795                 800 


Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val 
                805                 810                 815     


Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
            820                 825         


<210>  43
<211>  808
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL15GMCSF

<400>  43

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
    530                 535                 540                 


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
                565                 570                 575     


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
            580                 585                 590         


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
        595                 600                 605             


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
    610                 615                 620                 


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
625                 630                 635                 640 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
                645                 650                 655     


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro Ser 
        675                 680                 685             


Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg 
    690                 695                 700                 


Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr 
705                 710                 715                 720 


Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu 
                725                 730                 735     


Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr 
            740                 745                 750         


Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His 
        755                 760                 765             


Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe 
    770                 775                 780                 


Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe 
785                 790                 795                 800 


Asp Cys Trp Glu Pro Val Gln Glu 
                805             


<210>  44
<211>  808
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL21GMCSF

<400>  44

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
    530                 535                 540                 


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
545                 550                 555                 560 


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
                565                 570                 575     


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
            580                 585                 590         


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
        595                 600                 605             


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
    610                 615                 620                 


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
625                 630                 635                 640 


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
                645                 650                 655     


Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro Ser 
        675                 680                 685             


Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg 
    690                 695                 700                 


Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr 
705                 710                 715                 720 


Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu 
                725                 730                 735     


Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr 
            740                 745                 750         


Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His 
        755                 760                 765             


Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe 
    770                 775                 780                 


Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe 
785                 790                 795                 800 


Asp Cys Trp Glu Pro Val Gln Glu 
                805             


<210>  45
<211>  890
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2FLT3L

<400>  45

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
    530                 535                 540                 


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
545                 550                 555                 560 


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
                565                 570                 575     


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
            580                 585                 590         


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
        595                 600                 605             


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
    610                 615                 620                 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
625                 630                 635                 640 


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
                645                 650                 655     


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln 
        675                 680                 685             


His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 
    690                 695                 700                 


Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 
705                 710                 715                 720 


Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 
                725                 730                 735     


Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 
            740                 745                 750         


Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 
        755                 760                 765             


Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 
    770                 775                 780                 


Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 
785                 790                 795                 800 


Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 
                805                 810                 815     


Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr 
            820                 825                 830         


Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu Pro 
        835                 840                 845             


Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln Arg 
    850                 855                 860                 


Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val Pro 
865                 870                 875                 880 


Ser Pro Gln Asp Leu Leu Leu Val Glu His 
                885                 890 


<210>  46
<211>  909
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL7FLT3L

<400>  46

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln 
    530                 535                 540                 


Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met 
545                 550                 555                 560 


Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys 
                565                 570                 575     


Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala 
            580                 585                 590         


Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe 
        595                 600                 605             


Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn 
    610                 615                 620                 


Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala 
625                 630                 635                 640 


Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys 
                645                 650                 655     


Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys 
            660                 665                 670         


Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys 
    690                 695                 700                 


Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 
705                 710                 715                 720 


Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 
                725                 730                 735     


Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 
            740                 745                 750         


Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 
        755                 760                 765             


Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 
    770                 775                 780                 


Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 
785                 790                 795                 800 


Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 
                805                 810                 815     


Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 
            820                 825                 830         


Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu 
        835                 840                 845             


Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu 
    850                 855                 860                 


Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His 
865                 870                 875                 880 


Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro 
                885                 890                 895     


Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
            900                 905                 


<210>  47
<211>  890
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL15FLT3L

<400>  47

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
    530                 535                 540                 


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
                565                 570                 575     


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
            580                 585                 590         


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
        595                 600                 605             


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
    610                 615                 620                 


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
625                 630                 635                 640 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
                645                 650                 655     


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln 
        675                 680                 685             


His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 
    690                 695                 700                 


Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 
705                 710                 715                 720 


Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 
                725                 730                 735     


Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 
            740                 745                 750         


Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 
        755                 760                 765             


Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 
    770                 775                 780                 


Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 
785                 790                 795                 800 


Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 
                805                 810                 815     


Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr 
            820                 825                 830         


Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu Pro 
        835                 840                 845             


Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln Arg 
    850                 855                 860                 


Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val Pro 
865                 870                 875                 880 


Ser Pro Gln Asp Leu Leu Leu Val Glu His 
                885                 890 


<210>  48
<211>  890
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL21FLT3L

<400>  48

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
    530                 535                 540                 


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
545                 550                 555                 560 


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
                565                 570                 575     


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
            580                 585                 590         


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
        595                 600                 605             


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
    610                 615                 620                 


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
625                 630                 635                 640 


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
                645                 650                 655     


Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln 
        675                 680                 685             


His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 
    690                 695                 700                 


Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 
705                 710                 715                 720 


Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 
                725                 730                 735     


Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 
            740                 745                 750         


Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 
        755                 760                 765             


Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 
    770                 775                 780                 


Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 
785                 790                 795                 800 


Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 
                805                 810                 815     


Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr 
            820                 825                 830         


Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu Pro 
        835                 840                 845             


Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln Arg 
    850                 855                 860                 


Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val Pro 
865                 870                 875                 880 


Ser Pro Gln Asp Leu Leu Leu Val Glu His 
                885                 890 


<210>  49
<211>  1308
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19IL2GMCSF

<400>  49

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly 
            580                 585                 590         


Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
            660                 665                 670         


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe 
        675                 680                 685             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    690                 695                 700                 


Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
                725                 730                 735     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro 
            740                 745                 750         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu 
    770                 775                 780                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
785                 790                 795                 800 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg 
                805                 810                 815     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
            820                 825                 830         


Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        835                 840                 845             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    850                 855                 860                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr 
865                 870                 875                 880 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly 
                885                 890                 895     


Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
            900                 905                 910         


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
        915                 920                 925             


Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    930                 935                 940                 


Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
945                 950                 955                 960 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
                965                 970                 975     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile 
            980                 985                 990         


Pro Pro Thr Phe Gly Gln Gly Thr  Lys Val Glu Ile Lys  Gly Gly Gly 
        995                 1000                 1005             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Ala Pro Thr 
    1010                 1015                 1020             


Ser Ser  Ser Thr Ser Ser Ser  Thr Ala Glu Ala Gln  Gln Gln Gln 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln Gln  Gln His Leu Glu Gln  Leu Leu Met 
    1040                 1045                 1050             


Asp Leu  Gln Glu Leu Leu Ser  Arg Met Glu Asn Tyr  Arg Asn Leu 
    1055                 1060                 1065             


Lys Leu  Pro Arg Met Leu Thr  Phe Lys Phe Tyr Leu  Pro Lys Gln 
    1070                 1075                 1080             


Ala Thr  Glu Leu Lys Asp Leu  Gln Cys Leu Glu Asp  Glu Leu Gly 
    1085                 1090                 1095             


Pro Leu  Arg His Val Leu Asp  Leu Thr Gln Ser Lys  Ser Phe Gln 
    1100                 1105                 1110             


Leu Glu  Asp Ala Glu Asn Phe  Ile Ser Asn Ile Arg  Val Thr Val 
    1115                 1120                 1125             


Val Lys  Leu Lys Gly Ser Asp  Asn Thr Phe Glu Cys  Gln Phe Asp 
    1130                 1135                 1140             


Asp Glu  Ser Ala Thr Val Val  Asp Phe Leu Arg Arg  Trp Ile Ala 
    1145                 1150                 1155             


Phe Cys  Gln Ser Ile Ile Ser  Thr Ser Pro Gln Ser  Ser Ser Ser 
    1160                 1165                 1170             


Gly Ser  Ser Ser Ser Gly Ser  Ser Ser Ser Gly Ala  Pro Thr Arg 
    1175                 1180                 1185             


Ser Pro  Ile Thr Val Thr Arg  Pro Trp Lys His Val  Glu Ala Ile 
    1190                 1195                 1200             


Lys Glu  Ala Leu Asn Leu Leu  Asp Asp Met Pro Val  Thr Leu Asn 
    1205                 1210                 1215             


Glu Glu  Val Glu Val Val Ser  Asn Glu Phe Ser Phe  Lys Lys Leu 
    1220                 1225                 1230             


Thr Cys  Val Gln Thr Arg Leu  Lys Ile Phe Glu Gln  Gly Leu Arg 
    1235                 1240                 1245             


Gly Asn  Phe Thr Lys Leu Lys  Gly Ala Leu Asn Met  Thr Ala Ser 
    1250                 1255                 1260             


Tyr Tyr  Gln Thr Tyr Cys Pro  Pro Thr Pro Glu Thr  Asp Cys Glu 
    1265                 1270                 1275             


Thr Gln  Val Thr Thr Tyr Ala  Asp Phe Ile Asp Ser  Leu Lys Thr 
    1280                 1285                 1290             


Phe Leu  Thr Asp Ile Pro Phe  Glu Cys Lys Lys Pro  Gly Gln Lys 
    1295                 1300                 1305             


<210>  50
<211>  1316
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8IL2GMCSF

<400>  50

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu 
625                 630                 635                 640 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                645                 650                 655     


Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            660                 665                 670         


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        675                 680                 685             


Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    690                 695                 700                 


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                725                 730                 735     


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg 
            740                 745                 750         


Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser 
        755                 760                 765             


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val 
    770                 775                 780                 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
785                 790                 795                 800 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met 
                805                 810                 815     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
            820                 825                 830         


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        835                 840                 845             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    850                 855                 860                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
865                 870                 875                 880 


Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                885                 890                 895     


Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
            900                 905                 910         


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        915                 920                 925             


Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln 
    930                 935                 940                 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
945                 950                 955                 960 


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                965                 970                 975     


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            980                 985                 990         


Tyr Cys Gln Gln Met Arg Gly Arg  Pro Pro Thr Phe Gly  Gln Gly Thr 
        995                 1000                 1005             


Lys Val  Glu Ile Lys Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1010                 1015                 1020             


Gly Gly  Gly Gly Ser Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser 
    1025                 1030                 1035             


Thr Ala  Glu Ala Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1040                 1045                 1050             


Gln His  Leu Glu Gln Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser 
    1055                 1060                 1065             


Arg Met  Glu Asn Tyr Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr 
    1070                 1075                 1080             


Phe Lys  Phe Tyr Leu Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu 
    1085                 1090                 1095             


Gln Cys  Leu Glu Asp Glu Leu  Gly Pro Leu Arg His  Val Leu Asp 
    1100                 1105                 1110             


Leu Thr  Gln Ser Lys Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe 
    1115                 1120                 1125             


Ile Ser  Asn Ile Arg Val Thr  Val Val Lys Leu Lys  Gly Ser Asp 
    1130                 1135                 1140             


Asn Thr  Phe Glu Cys Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val 
    1145                 1150                 1155             


Asp Phe  Leu Arg Arg Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser 
    1160                 1165                 1170             


Thr Ser  Pro Gln Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser 
    1175                 1180                 1185             


Ser Ser  Ser Gly Ala Pro Thr  Arg Ser Pro Ile Thr  Val Thr Arg 
    1190                 1195                 1200             


Pro Trp  Lys His Val Glu Ala  Ile Lys Glu Ala Leu  Asn Leu Leu 
    1205                 1210                 1215             


Asp Asp  Met Pro Val Thr Leu  Asn Glu Glu Val Glu  Val Val Ser 
    1220                 1225                 1230             


Asn Glu  Phe Ser Phe Lys Lys  Leu Thr Cys Val Gln  Thr Arg Leu 
    1235                 1240                 1245             


Lys Ile  Phe Glu Gln Gly Leu  Arg Gly Asn Phe Thr  Lys Leu Lys 
    1250                 1255                 1260             


Gly Ala  Leu Asn Met Thr Ala  Ser Tyr Tyr Gln Thr  Tyr Cys Pro 
    1265                 1270                 1275             


Pro Thr  Pro Glu Thr Asp Cys  Glu Thr Gln Val Thr  Thr Tyr Ala 
    1280                 1285                 1290             


Asp Phe  Ile Asp Ser Leu Lys  Thr Phe Leu Thr Asp  Ile Pro Phe 
    1295                 1300                 1305             


Glu Cys  Lys Lys Pro Gly Gln  Lys 
    1310                 1315     


<210>  51
<211>  1314
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76IL2GMCSF

<400>  51

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
    530                 535                 540                 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val 
545                 550                 555                 560 


Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln 
                565                 570                 575     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
        595                 600                 605             


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
    610                 615                 620                 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
                645                 650                 655     


Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 
            660                 665                 670         


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
        675                 680                 685             


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
    690                 695                 700                 


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
705                 710                 715                 720 


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
                725                 730                 735     


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly 
            740                 745                 750         


Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser 
        755                 760                 765             


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Gln Val Gln 
    770                 775                 780                 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
785                 790                 795                 800 


Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp 
                805                 810                 815     


Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser 
            820                 825                 830         


Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
        835                 840                 845             


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
    850                 855                 860                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
865                 870                 875                 880 


Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                885                 890                 895     


Ser Ser Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala 
            900                 905                 910         


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
        915                 920                 925             


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
    930                 935                 940                 


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
945                 950                 955                 960 


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
                965                 970                 975     


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
            980                 985                 990         


Arg Asp Ser Ser Gly Asn His Val  Val Phe Gly Gly Gly  Thr Lys Leu 
        995                 1000                 1005             


Thr Val  Leu Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1010                 1015                 1020             


Gly Gly  Ser Ala Pro Thr Ser  Ser Ser Thr Ser Ser  Ser Thr Ala 
    1025                 1030                 1035             


Glu Ala  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His 
    1040                 1045                 1050             


Leu Glu  Gln Leu Leu Met Asp  Leu Gln Glu Leu Leu  Ser Arg Met 
    1055                 1060                 1065             


Glu Asn  Tyr Arg Asn Leu Lys  Leu Pro Arg Met Leu  Thr Phe Lys 
    1070                 1075                 1080             


Phe Tyr  Leu Pro Lys Gln Ala  Thr Glu Leu Lys Asp  Leu Gln Cys 
    1085                 1090                 1095             


Leu Glu  Asp Glu Leu Gly Pro  Leu Arg His Val Leu  Asp Leu Thr 
    1100                 1105                 1110             


Gln Ser  Lys Ser Phe Gln Leu  Glu Asp Ala Glu Asn  Phe Ile Ser 
    1115                 1120                 1125             


Asn Ile  Arg Val Thr Val Val  Lys Leu Lys Gly Ser  Asp Asn Thr 
    1130                 1135                 1140             


Phe Glu  Cys Gln Phe Asp Asp  Glu Ser Ala Thr Val  Val Asp Phe 
    1145                 1150                 1155             


Leu Arg  Arg Trp Ile Ala Phe  Cys Gln Ser Ile Ile  Ser Thr Ser 
    1160                 1165                 1170             


Pro Gln  Ser Ser Ser Ser Gly  Ser Ser Ser Ser Gly  Ser Ser Ser 
    1175                 1180                 1185             


Ser Gly  Ala Pro Thr Arg Ser  Pro Ile Thr Val Thr  Arg Pro Trp 
    1190                 1195                 1200             


Lys His  Val Glu Ala Ile Lys  Glu Ala Leu Asn Leu  Leu Asp Asp 
    1205                 1210                 1215             


Met Pro  Val Thr Leu Asn Glu  Glu Val Glu Val Val  Ser Asn Glu 
    1220                 1225                 1230             


Phe Ser  Phe Lys Lys Leu Thr  Cys Val Gln Thr Arg  Leu Lys Ile 
    1235                 1240                 1245             


Phe Glu  Gln Gly Leu Arg Gly  Asn Phe Thr Lys Leu  Lys Gly Ala 
    1250                 1255                 1260             


Leu Asn  Met Thr Ala Ser Tyr  Tyr Gln Thr Tyr Cys  Pro Pro Thr 
    1265                 1270                 1275             


Pro Glu  Thr Asp Cys Glu Thr  Gln Val Thr Thr Tyr  Ala Asp Phe 
    1280                 1285                 1290             


Ile Asp  Ser Leu Lys Thr Phe  Leu Thr Asp Ile Pro  Phe Glu Cys 
    1295                 1300                 1305             


Lys Lys  Pro Gly Gln Lys 
    1310                 


<210>  52
<211>  1315
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76F8IL2GMCSF

<400>  52

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
    530                 535                 540                 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val 
545                 550                 555                 560 


Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln 
                565                 570                 575     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
        595                 600                 605             


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
    610                 615                 620                 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
                645                 650                 655     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
            660                 665                 670         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        675                 680                 685             


Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    690                 695                 700                 


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
705                 710                 715                 720 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                725                 730                 735     


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly 
            740                 745                 750         


Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser 
        755                 760                 765             


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln 
    770                 775                 780                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
785                 790                 795                 800 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser 
                805                 810                 815     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
            820                 825                 830         


Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        835                 840                 845             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    850                 855                 860                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser 
865                 870                 875                 880 


Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                885                 890                 895     


Val Ser Ser Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
            900                 905                 910         


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
        915                 920                 925             


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
    930                 935                 940                 


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
945                 950                 955                 960 


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
                965                 970                 975     


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
            980                 985                 990         


Ser Arg Asp Ser Ser Gly Asn His  Val Val Phe Gly Gly  Gly Thr Lys 
        995                 1000                 1005             


Leu Thr  Val Leu Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1010                 1015                 1020             


Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser Thr Ser  Ser Ser Thr 
    1025                 1030                 1035             


Ala Glu  Ala Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1040                 1045                 1050             


His Leu  Glu Gln Leu Leu Met  Asp Leu Gln Glu Leu  Leu Ser Arg 
    1055                 1060                 1065             


Met Glu  Asn Tyr Arg Asn Leu  Lys Leu Pro Arg Met  Leu Thr Phe 
    1070                 1075                 1080             


Lys Phe  Tyr Leu Pro Lys Gln  Ala Thr Glu Leu Lys  Asp Leu Gln 
    1085                 1090                 1095             


Cys Leu  Glu Asp Glu Leu Gly  Pro Leu Arg His Val  Leu Asp Leu 
    1100                 1105                 1110             


Thr Gln  Ser Lys Ser Phe Gln  Leu Glu Asp Ala Glu  Asn Phe Ile 
    1115                 1120                 1125             


Ser Asn  Ile Arg Val Thr Val  Val Lys Leu Lys Gly  Ser Asp Asn 
    1130                 1135                 1140             


Thr Phe  Glu Cys Gln Phe Asp  Asp Glu Ser Ala Thr  Val Val Asp 
    1145                 1150                 1155             


Phe Leu  Arg Arg Trp Ile Ala  Phe Cys Gln Ser Ile  Ile Ser Thr 
    1160                 1165                 1170             


Ser Pro  Gln Ser Ser Ser Ser  Gly Ser Ser Ser Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ser Ser  Gly Ala Pro Thr Arg  Ser Pro Ile Thr Val  Thr Arg Pro 
    1190                 1195                 1200             


Trp Lys  His Val Glu Ala Ile  Lys Glu Ala Leu Asn  Leu Leu Asp 
    1205                 1210                 1215             


Asp Met  Pro Val Thr Leu Asn  Glu Glu Val Glu Val  Val Ser Asn 
    1220                 1225                 1230             


Glu Phe  Ser Phe Lys Lys Leu  Thr Cys Val Gln Thr  Arg Leu Lys 
    1235                 1240                 1245             


Ile Phe  Glu Gln Gly Leu Arg  Gly Asn Phe Thr Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ala Leu  Asn Met Thr Ala Ser  Tyr Tyr Gln Thr Tyr  Cys Pro Pro 
    1265                 1270                 1275             


Thr Pro  Glu Thr Asp Cys Glu  Thr Gln Val Thr Thr  Tyr Ala Asp 
    1280                 1285                 1290             


Phe Ile  Asp Ser Leu Lys Thr  Phe Leu Thr Asp Ile  Pro Phe Glu 
    1295                 1300                 1305             


Cys Lys  Lys Pro Gly Gln Lys  
    1310                 1315 


<210>  53
<211>  1311
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76L19IL2GMCSF

<400>  53

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
    530                 535                 540                 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val 
545                 550                 555                 560 


Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln 
                565                 570                 575     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
        595                 600                 605             


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
    610                 615                 620                 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
                645                 650                 655     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
            660                 665                 670         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        675                 680                 685             


Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    690                 695                 700                 


Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
705                 710                 715                 720 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                725                 730                 735     


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg 
            740                 745                 750         


Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser 
        755                 760                 765             


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln 
    770                 775                 780                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
785                 790                 795                 800 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser 
                805                 810                 815     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            820                 825                 830         


Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        835                 840                 845             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    850                 855                 860                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro 
865                 870                 875                 880 


Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gly 
                885                 890                 895     


Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
            900                 905                 910         


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
        915                 920                 925             


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    930                 935                 940                 


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
945                 950                 955                 960 


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
                965                 970                 975     


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
            980                 985                 990         


Ser Gly Asn His Val Val Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu 
        995                 1000                 1005             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1010                 1015                 1020             


Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser Thr Ala  Glu Ala Gln 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln His  Leu Glu Gln 
    1040                 1045                 1050             


Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser Arg Met  Glu Asn Tyr 
    1055                 1060                 1065             


Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr Phe Lys  Phe Tyr Leu 
    1070                 1075                 1080             


Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu Gln Cys  Leu Glu Asp 
    1085                 1090                 1095             


Glu Leu  Gly Pro Leu Arg His  Val Leu Asp Leu Thr  Gln Ser Lys 
    1100                 1105                 1110             


Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe Ile Ser  Asn Ile Arg 
    1115                 1120                 1125             


Val Thr  Val Val Lys Leu Lys  Gly Ser Asp Asn Thr  Phe Glu Cys 
    1130                 1135                 1140             


Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val Asp Phe  Leu Arg Arg 
    1145                 1150                 1155             


Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser Thr Ser  Pro Gln Ser 
    1160                 1165                 1170             


Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ala 
    1175                 1180                 1185             


Pro Thr  Arg Ser Pro Ile Thr  Val Thr Arg Pro Trp  Lys His Val 
    1190                 1195                 1200             


Glu Ala  Ile Lys Glu Ala Leu  Asn Leu Leu Asp Asp  Met Pro Val 
    1205                 1210                 1215             


Thr Leu  Asn Glu Glu Val Glu  Val Val Ser Asn Glu  Phe Ser Phe 
    1220                 1225                 1230             


Lys Lys  Leu Thr Cys Val Gln  Thr Arg Leu Lys Ile  Phe Glu Gln 
    1235                 1240                 1245             


Gly Leu  Arg Gly Asn Phe Thr  Lys Leu Lys Gly Ala  Leu Asn Met 
    1250                 1255                 1260             


Thr Ala  Ser Tyr Tyr Gln Thr  Tyr Cys Pro Pro Thr  Pro Glu Thr 
    1265                 1270                 1275             


Asp Cys  Glu Thr Gln Val Thr  Thr Tyr Ala Asp Phe  Ile Asp Ser 
    1280                 1285                 1290             


Leu Lys  Thr Phe Leu Thr Asp  Ile Pro Phe Glu Cys  Lys Lys Pro 
    1295                 1300                 1305             


Gly Gln  Lys 
    1310     


<210>  54
<211>  1315
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8NHS76IL2GMCSF

<400>  54

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu 
625                 630                 635                 640 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                645                 650                 655     


Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            660                 665                 670         


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser 
        675                 680                 685             


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    690                 695                 700                 


Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 
705                 710                 715                 720 


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                725                 730                 735     


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser 
            740                 745                 750         


Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser 
        755                 760                 765             


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Gln Val 
    770                 775                 780                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
785                 790                 795                 800 


Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr 
                805                 810                 815     


Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            820                 825                 830         


Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
        835                 840                 845             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
    850                 855                 860                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
865                 870                 875                 880 


Gly Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                885                 890                 895     


Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro 
            900                 905                 910         


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
        915                 920                 925             


Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys 
    930                 935                 940                 


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
945                 950                 955                 960 


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                965                 970                 975     


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            980                 985                 990         


Cys Gln Gln Met Arg Gly Arg Pro  Pro Thr Phe Gly Gln  Gly Thr Lys 
        995                 1000                 1005             


Val Glu  Ile Lys Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1010                 1015                 1020             


Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser Thr Ser  Ser Ser Thr 
    1025                 1030                 1035             


Ala Glu  Ala Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1040                 1045                 1050             


His Leu  Glu Gln Leu Leu Met  Asp Leu Gln Glu Leu  Leu Ser Arg 
    1055                 1060                 1065             


Met Glu  Asn Tyr Arg Asn Leu  Lys Leu Pro Arg Met  Leu Thr Phe 
    1070                 1075                 1080             


Lys Phe  Tyr Leu Pro Lys Gln  Ala Thr Glu Leu Lys  Asp Leu Gln 
    1085                 1090                 1095             


Cys Leu  Glu Asp Glu Leu Gly  Pro Leu Arg His Val  Leu Asp Leu 
    1100                 1105                 1110             


Thr Gln  Ser Lys Ser Phe Gln  Leu Glu Asp Ala Glu  Asn Phe Ile 
    1115                 1120                 1125             


Ser Asn  Ile Arg Val Thr Val  Val Lys Leu Lys Gly  Ser Asp Asn 
    1130                 1135                 1140             


Thr Phe  Glu Cys Gln Phe Asp  Asp Glu Ser Ala Thr  Val Val Asp 
    1145                 1150                 1155             


Phe Leu  Arg Arg Trp Ile Ala  Phe Cys Gln Ser Ile  Ile Ser Thr 
    1160                 1165                 1170             


Ser Pro  Gln Ser Ser Ser Ser  Gly Ser Ser Ser Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ser Ser  Gly Ala Pro Thr Arg  Ser Pro Ile Thr Val  Thr Arg Pro 
    1190                 1195                 1200             


Trp Lys  His Val Glu Ala Ile  Lys Glu Ala Leu Asn  Leu Leu Asp 
    1205                 1210                 1215             


Asp Met  Pro Val Thr Leu Asn  Glu Glu Val Glu Val  Val Ser Asn 
    1220                 1225                 1230             


Glu Phe  Ser Phe Lys Lys Leu  Thr Cys Val Gln Thr  Arg Leu Lys 
    1235                 1240                 1245             


Ile Phe  Glu Gln Gly Leu Arg  Gly Asn Phe Thr Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ala Leu  Asn Met Thr Ala Ser  Tyr Tyr Gln Thr Tyr  Cys Pro Pro 
    1265                 1270                 1275             


Thr Pro  Glu Thr Asp Cys Glu  Thr Gln Val Thr Thr  Tyr Ala Asp 
    1280                 1285                 1290             


Phe Ile  Asp Ser Leu Lys Thr  Phe Leu Thr Asp Ile  Pro Phe Glu 
    1295                 1300                 1305             


Cys Lys  Lys Pro Gly Gln Lys  
    1310                 1315 


<210>  55
<211>  1312
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8L19IL2GMCSF

<400>  55

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
            580                 585                 590         


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu 
625                 630                 635                 640 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                645                 650                 655     


Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            660                 665                 670         


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        675                 680                 685             


Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    690                 695                 700                 


Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                725                 730                 735     


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly 
            740                 745                 750         


Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser 
        755                 760                 765             


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val 
    770                 775                 780                 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
785                 790                 795                 800 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ser Met 
                805                 810                 815     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            820                 825                 830         


Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        835                 840                 845             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    850                 855                 860                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
865                 870                 875                 880 


Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                885                 890                 895     


Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            900                 905                 910         


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        915                 920                 925             


Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    930                 935                 940                 


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
945                 950                 955                 960 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                965                 970                 975     


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            980                 985                 990         


Met Arg Gly Arg Pro Pro Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
        995                 1000                 1005             


Lys Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Ala  Pro Thr Ser Ser Ser  Thr Ser Ser Ser Thr  Ala Glu Ala 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Leu Glu 
    1040                 1045                 1050             


Gln Leu  Leu Met Asp Leu Gln  Glu Leu Leu Ser Arg  Met Glu Asn 
    1055                 1060                 1065             


Tyr Arg  Asn Leu Lys Leu Pro  Arg Met Leu Thr Phe  Lys Phe Tyr 
    1070                 1075                 1080             


Leu Pro  Lys Gln Ala Thr Glu  Leu Lys Asp Leu Gln  Cys Leu Glu 
    1085                 1090                 1095             


Asp Glu  Leu Gly Pro Leu Arg  His Val Leu Asp Leu  Thr Gln Ser 
    1100                 1105                 1110             


Lys Ser  Phe Gln Leu Glu Asp  Ala Glu Asn Phe Ile  Ser Asn Ile 
    1115                 1120                 1125             


Arg Val  Thr Val Val Lys Leu  Lys Gly Ser Asp Asn  Thr Phe Glu 
    1130                 1135                 1140             


Cys Gln  Phe Asp Asp Glu Ser  Ala Thr Val Val Asp  Phe Leu Arg 
    1145                 1150                 1155             


Arg Trp  Ile Ala Phe Cys Gln  Ser Ile Ile Ser Thr  Ser Pro Gln 
    1160                 1165                 1170             


Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly 
    1175                 1180                 1185             


Ala Pro  Thr Arg Ser Pro Ile  Thr Val Thr Arg Pro  Trp Lys His 
    1190                 1195                 1200             


Val Glu  Ala Ile Lys Glu Ala  Leu Asn Leu Leu Asp  Asp Met Pro 
    1205                 1210                 1215             


Val Thr  Leu Asn Glu Glu Val  Glu Val Val Ser Asn  Glu Phe Ser 
    1220                 1225                 1230             


Phe Lys  Lys Leu Thr Cys Val  Gln Thr Arg Leu Lys  Ile Phe Glu 
    1235                 1240                 1245             


Gln Gly  Leu Arg Gly Asn Phe  Thr Lys Leu Lys Gly  Ala Leu Asn 
    1250                 1255                 1260             


Met Thr  Ala Ser Tyr Tyr Gln  Thr Tyr Cys Pro Pro  Thr Pro Glu 
    1265                 1270                 1275             


Thr Asp  Cys Glu Thr Gln Val  Thr Thr Tyr Ala Asp  Phe Ile Asp 
    1280                 1285                 1290             


Ser Leu  Lys Thr Phe Leu Thr  Asp Ile Pro Phe Glu  Cys Lys Lys 
    1295                 1300                 1305             


Pro Gly  Gln Lys 
    1310         


<210>  56
<211>  1311
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19NHS76IL2GMCSF

<400>  56

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly 
            580                 585                 590         


Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
            660                 665                 670         


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
        675                 680                 685             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
    690                 695                 700                 


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
705                 710                 715                 720 


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
                725                 730                 735     


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
            740                 745                 750         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu 
    770                 775                 780                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
785                 790                 795                 800 


Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
                805                 810                 815     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His 
            820                 825                 830         


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
        835                 840                 845             


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    850                 855                 860                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser 
865                 870                 875                 880 


Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                885                 890                 895     


Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            900                 905                 910         


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        915                 920                 925             


Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    930                 935                 940                 


Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro 
945                 950                 955                 960 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                965                 970                 975     


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr 
            980                 985                 990         


Gly Arg Ile Pro Pro Thr Phe Gly  Gln Gly Thr Lys Val  Glu Ile Lys 
        995                 1000                 1005             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1010                 1015                 1020             


Ala Pro  Thr Ser Ser Ser Thr  Ser Ser Ser Thr Ala  Glu Ala Gln 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln His  Leu Glu Gln 
    1040                 1045                 1050             


Leu Leu  Met Asp Leu Gln Glu  Leu Leu Ser Arg Met  Glu Asn Tyr 
    1055                 1060                 1065             


Arg Asn  Leu Lys Leu Pro Arg  Met Leu Thr Phe Lys  Phe Tyr Leu 
    1070                 1075                 1080             


Pro Lys  Gln Ala Thr Glu Leu  Lys Asp Leu Gln Cys  Leu Glu Asp 
    1085                 1090                 1095             


Glu Leu  Gly Pro Leu Arg His  Val Leu Asp Leu Thr  Gln Ser Lys 
    1100                 1105                 1110             


Ser Phe  Gln Leu Glu Asp Ala  Glu Asn Phe Ile Ser  Asn Ile Arg 
    1115                 1120                 1125             


Val Thr  Val Val Lys Leu Lys  Gly Ser Asp Asn Thr  Phe Glu Cys 
    1130                 1135                 1140             


Gln Phe  Asp Asp Glu Ser Ala  Thr Val Val Asp Phe  Leu Arg Arg 
    1145                 1150                 1155             


Trp Ile  Ala Phe Cys Gln Ser  Ile Ile Ser Thr Ser  Pro Gln Ser 
    1160                 1165                 1170             


Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ala 
    1175                 1180                 1185             


Pro Thr  Arg Ser Pro Ile Thr  Val Thr Arg Pro Trp  Lys His Val 
    1190                 1195                 1200             


Glu Ala  Ile Lys Glu Ala Leu  Asn Leu Leu Asp Asp  Met Pro Val 
    1205                 1210                 1215             


Thr Leu  Asn Glu Glu Val Glu  Val Val Ser Asn Glu  Phe Ser Phe 
    1220                 1225                 1230             


Lys Lys  Leu Thr Cys Val Gln  Thr Arg Leu Lys Ile  Phe Glu Gln 
    1235                 1240                 1245             


Gly Leu  Arg Gly Asn Phe Thr  Lys Leu Lys Gly Ala  Leu Asn Met 
    1250                 1255                 1260             


Thr Ala  Ser Tyr Tyr Gln Thr  Tyr Cys Pro Pro Thr  Pro Glu Thr 
    1265                 1270                 1275             


Asp Cys  Glu Thr Gln Val Thr  Thr Tyr Ala Asp Phe  Ile Asp Ser 
    1280                 1285                 1290             


Leu Lys  Thr Phe Leu Thr Asp  Ile Pro Phe Glu Cys  Lys Lys Pro 
    1295                 1300                 1305             


Gly Gln  Lys 
    1310     


<210>  57
<211>  1312
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19F8IL2GMCSF

<400>  57

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly 
            580                 585                 590         


Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
            660                 665                 670         


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe 
        675                 680                 685             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    690                 695                 700                 


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
                725                 730                 735     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro 
            740                 745                 750         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu 
    770                 775                 780                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
785                 790                 795                 800 


Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg 
                805                 810                 815     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
            820                 825                 830         


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        835                 840                 845             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    850                 855                 860                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu 
865                 870                 875                 880 


Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                885                 890                 895     


Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            900                 905                 910         


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        915                 920                 925             


Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    930                 935                 940                 


Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile 
945                 950                 955                 960 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                965                 970                 975     


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            980                 985                 990         


Thr Gly Arg Ile Pro Pro Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
        995                 1000                 1005             


Lys Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Ala  Pro Thr Ser Ser Ser  Thr Ser Ser Ser Thr  Ala Glu Ala 
    1025                 1030                 1035             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Leu Glu 
    1040                 1045                 1050             


Gln Leu  Leu Met Asp Leu Gln  Glu Leu Leu Ser Arg  Met Glu Asn 
    1055                 1060                 1065             


Tyr Arg  Asn Leu Lys Leu Pro  Arg Met Leu Thr Phe  Lys Phe Tyr 
    1070                 1075                 1080             


Leu Pro  Lys Gln Ala Thr Glu  Leu Lys Asp Leu Gln  Cys Leu Glu 
    1085                 1090                 1095             


Asp Glu  Leu Gly Pro Leu Arg  His Val Leu Asp Leu  Thr Gln Ser 
    1100                 1105                 1110             


Lys Ser  Phe Gln Leu Glu Asp  Ala Glu Asn Phe Ile  Ser Asn Ile 
    1115                 1120                 1125             


Arg Val  Thr Val Val Lys Leu  Lys Gly Ser Asp Asn  Thr Phe Glu 
    1130                 1135                 1140             


Cys Gln  Phe Asp Asp Glu Ser  Ala Thr Val Val Asp  Phe Leu Arg 
    1145                 1150                 1155             


Arg Trp  Ile Ala Phe Cys Gln  Ser Ile Ile Ser Thr  Ser Pro Gln 
    1160                 1165                 1170             


Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly 
    1175                 1180                 1185             


Ala Pro  Thr Arg Ser Pro Ile  Thr Val Thr Arg Pro  Trp Lys His 
    1190                 1195                 1200             


Val Glu  Ala Ile Lys Glu Ala  Leu Asn Leu Leu Asp  Asp Met Pro 
    1205                 1210                 1215             


Val Thr  Leu Asn Glu Glu Val  Glu Val Val Ser Asn  Glu Phe Ser 
    1220                 1225                 1230             


Phe Lys  Lys Leu Thr Cys Val  Gln Thr Arg Leu Lys  Ile Phe Glu 
    1235                 1240                 1245             


Gln Gly  Leu Arg Gly Asn Phe  Thr Lys Leu Lys Gly  Ala Leu Asn 
    1250                 1255                 1260             


Met Thr  Ala Ser Tyr Tyr Gln  Thr Tyr Cys Pro Pro  Thr Pro Glu 
    1265                 1270                 1275             


Thr Asp  Cys Glu Thr Gln Val  Thr Thr Tyr Ala Asp  Phe Ile Asp 
    1280                 1285                 1290             


Ser Leu  Lys Thr Phe Leu Thr  Asp Ile Pro Phe Glu  Cys Lys Lys 
    1295                 1300                 1305             


Pro Gly  Gln Lys 
    1310         


<210>  58
<211>  1315
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaNHS76F8GMCSF

<400>  58

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    690                 695                 700                 


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
705                 710                 715                 720 


Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly 
                725                 730                 735     


Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile 
            740                 745                 750         


Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val 
        755                 760                 765             


Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
    770                 775                 780                 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys 
785                 790                 795                 800 


Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                805                 810                 815     


Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
            820                 825                 830         


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        835                 840                 845             


Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    850                 855                 860                 


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
865                 870                 875                 880 


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                885                 890                 895     


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            900                 905                 910         


Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        915                 920                 925             


Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
    930                 935                 940                 


Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
945                 950                 955                 960 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu 
                965                 970                 975     


Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            980                 985                 990         


Val Ser Ala Ile Ser Gly Ser Gly  Gly Ser Thr Tyr Tyr  Ala Asp Ser 
        995                 1000                 1005             


Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp Asn Ser  Lys Asn Thr 
    1010                 1015                 1020             


Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1025                 1030                 1035             


Tyr Tyr  Cys Ala Lys Ser Thr  His Leu Tyr Leu Phe  Asp Tyr Trp 
    1040                 1045                 1050             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Gly Gly  Ser Gly Gly 
    1055                 1060                 1065             


Ser Ser  Glu Leu Thr Gln Asp  Pro Ala Val Ser Val  Ala Leu Gly 
    1070                 1075                 1080             


Gln Thr  Val Arg Ile Thr Cys  Gln Gly Asp Ser Leu  Arg Ser Tyr 
    1085                 1090                 1095             


Tyr Ala  Ser Trp Tyr Gln Gln  Lys Pro Gly Gln Ala  Pro Val Leu 
    1100                 1105                 1110             


Val Ile  Tyr Gly Lys Asn Asn  Arg Pro Ser Gly Ile  Pro Asp Arg 
    1115                 1120                 1125             


Phe Ser  Gly Ser Ser Ser Gly  Asn Thr Ala Ser Leu  Thr Ile Thr 
    1130                 1135                 1140             


Gly Ala  Gln Ala Glu Asp Glu  Ala Asp Tyr Tyr Cys  Asn Ser Arg 
    1145                 1150                 1155             


Asp Ser  Ser Gly Asn His Val  Val Phe Gly Gly Gly  Thr Lys Leu 
    1160                 1165                 1170             


Thr Val  Leu Ser Ser Ser Ser  Gly Ser Ser Ser Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ser Ser  Gly Ala Pro Thr Arg  Ser Pro Ile Thr Val  Thr Arg Pro 
    1190                 1195                 1200             


Trp Lys  His Val Glu Ala Ile  Lys Glu Ala Leu Asn  Leu Leu Asp 
    1205                 1210                 1215             


Asp Met  Pro Val Thr Leu Asn  Glu Glu Val Glu Val  Val Ser Asn 
    1220                 1225                 1230             


Glu Phe  Ser Phe Lys Lys Leu  Thr Cys Val Gln Thr  Arg Leu Lys 
    1235                 1240                 1245             


Ile Phe  Glu Gln Gly Leu Arg  Gly Asn Phe Thr Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ala Leu  Asn Met Thr Ala Ser  Tyr Tyr Gln Thr Tyr  Cys Pro Pro 
    1265                 1270                 1275             


Thr Pro  Glu Thr Asp Cys Glu  Thr Gln Val Thr Thr  Tyr Ala Asp 
    1280                 1285                 1290             


Phe Ile  Asp Ser Leu Lys Thr  Phe Leu Thr Asp Ile  Pro Phe Glu 
    1295                 1300                 1305             


Cys Lys  Lys Pro Gly Gln Lys  
    1310                 1315 


<210>  59
<211>  1316
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaF8GMCSF

<400>  59

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    690                 695                 700                 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
705                 710                 715                 720 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp 
                725                 730                 735     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser 
            740                 745                 750         


Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        755                 760                 765             


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
    770                 775                 780                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr 
785                 790                 795                 800 


His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                805                 810                 815     


Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
            820                 825                 830         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        835                 840                 845             


Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
    850                 855                 860                 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
865                 870                 875                 880 


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                885                 890                 895     


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            900                 905                 910         


Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
        915                 920                 925             


Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
    930                 935                 940                 


Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
945                 950                 955                 960 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                965                 970                 975     


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            980                 985                 990         


Trp Val Ser Ala Ile Ser Gly Ser  Gly Gly Ser Thr Tyr  Tyr Ala Asp 
        995                 1000                 1005             


Ser Val  Lys Gly Arg Phe Thr  Ile Ser Arg Asp Asn  Ser Lys Asn 
    1010                 1015                 1020             


Thr Leu  Tyr Leu Gln Met Asn  Ser Leu Arg Ala Glu  Asp Thr Ala 
    1025                 1030                 1035             


Val Tyr  Tyr Cys Ala Lys Ser  Thr His Leu Tyr Leu  Phe Asp Tyr 
    1040                 1045                 1050             


Trp Gly  Gln Gly Thr Leu Val  Thr Val Ser Ser Gly  Gly Ser Gly 
    1055                 1060                 1065             


Gly Glu  Ile Val Leu Thr Gln  Ser Pro Gly Thr Leu  Ser Leu Ser 
    1070                 1075                 1080             


Pro Gly  Glu Arg Ala Thr Leu  Ser Cys Arg Ala Ser  Gln Ser Val 
    1085                 1090                 1095             


Ser Met  Pro Phe Leu Ala Trp  Tyr Gln Gln Lys Pro  Gly Gln Ala 
    1100                 1105                 1110             


Pro Arg  Leu Leu Ile Tyr Gly  Ala Ser Ser Arg Ala  Thr Gly Ile 
    1115                 1120                 1125             


Pro Asp  Arg Phe Ser Gly Ser  Gly Ser Gly Thr Asp  Phe Thr Leu 
    1130                 1135                 1140             


Thr Ile  Ser Arg Leu Glu Pro  Glu Asp Phe Ala Val  Tyr Tyr Cys 
    1145                 1150                 1155             


Gln Gln  Met Arg Gly Arg Pro  Pro Thr Phe Gly Gln  Gly Thr Lys 
    1160                 1165                 1170             


Val Glu  Ile Lys Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser 
    1175                 1180                 1185             


Ser Ser  Ser Gly Ala Pro Thr  Arg Ser Pro Ile Thr  Val Thr Arg 
    1190                 1195                 1200             


Pro Trp  Lys His Val Glu Ala  Ile Lys Glu Ala Leu  Asn Leu Leu 
    1205                 1210                 1215             


Asp Asp  Met Pro Val Thr Leu  Asn Glu Glu Val Glu  Val Val Ser 
    1220                 1225                 1230             


Asn Glu  Phe Ser Phe Lys Lys  Leu Thr Cys Val Gln  Thr Arg Leu 
    1235                 1240                 1245             


Lys Ile  Phe Glu Gln Gly Leu  Arg Gly Asn Phe Thr  Lys Leu Lys 
    1250                 1255                 1260             


Gly Ala  Leu Asn Met Thr Ala  Ser Tyr Tyr Gln Thr  Tyr Cys Pro 
    1265                 1270                 1275             


Pro Thr  Pro Glu Thr Asp Cys  Glu Thr Gln Val Thr  Thr Tyr Ala 
    1280                 1285                 1290             


Asp Phe  Ile Asp Ser Leu Lys  Thr Phe Leu Thr Asp  Ile Pro Phe 
    1295                 1300                 1305             


Glu Cys  Lys Lys Pro Gly Gln  Lys 
    1310                 1315     


<210>  60
<211>  1315
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSFDiaNHS76F8

<400>  60

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg 
    690                 695                 700                 


Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys 
705                 710                 715                 720 


Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu 
                725                 730                 735     


Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val 
            740                 745                 750         


Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr 
        755                 760                 765             


Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr 
    770                 775                 780                 


Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr 
785                 790                 795                 800 


Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe 
                805                 810                 815     


Glu Cys Lys Lys Pro Gly Gln Lys Ser Ser Ser Ser Gly Ser Ser Ser 
            820                 825                 830         


Ser Gly Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu Ser Gly Pro 
        835                 840                 845             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser 
    850                 855                 860                 


Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
865                 870                 875                 880 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser 
                885                 890                 895     


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
            900                 905                 910         


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
        915                 920                 925             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp 
    930                 935                 940                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
                965                 970                 975     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met 
            980                 985                 990         


Pro Phe Leu Ala Trp Tyr Gln Gln  Lys Pro Gly Gln Ala  Pro Arg Leu 
        995                 1000                 1005             


Leu Ile  Tyr Gly Ala Ser Ser  Arg Ala Thr Gly Ile  Pro Asp Arg 
    1010                 1015                 1020             


Phe Ser  Gly Ser Gly Ser Gly  Thr Asp Phe Thr Leu  Thr Ile Ser 
    1025                 1030                 1035             


Arg Leu  Glu Pro Glu Asp Phe  Ala Val Tyr Tyr Cys  Gln Gln Met 
    1040                 1045                 1050             


Arg Gly  Arg Pro Pro Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
    1055                 1060                 1065             


Lys Ser  Ser Ser Ser Gly Ser  Ser Ser Ser Gly Ser  Ser Ser Ser 
    1070                 1075                 1080             


Gly Glu  Val Gln Leu Leu Glu  Ser Gly Gly Gly Leu  Val Gln Pro 
    1085                 1090                 1095             


Gly Gly  Ser Leu Arg Leu Ser  Cys Ala Ala Ser Gly  Phe Thr Phe 
    1100                 1105                 1110             


Ser Leu  Phe Thr Met Ser Trp  Val Arg Gln Ala Pro  Gly Lys Gly 
    1115                 1120                 1125             


Leu Glu  Trp Val Ser Ala Ile  Ser Gly Ser Gly Gly  Ser Thr Tyr 
    1130                 1135                 1140             


Tyr Ala  Asp Ser Val Lys Gly  Arg Phe Thr Ile Ser  Arg Asp Asn 
    1145                 1150                 1155             


Ser Lys  Asn Thr Leu Tyr Leu  Gln Met Asn Ser Leu  Arg Ala Glu 
    1160                 1165                 1170             


Asp Thr  Ala Val Tyr Tyr Cys  Ala Lys Ser Thr His  Leu Tyr Leu 
    1175                 1180                 1185             


Phe Asp  Tyr Trp Gly Gln Gly  Thr Leu Val Thr Val  Ser Ser Gly 
    1190                 1195                 1200             


Gly Ser  Gly Gly Ser Ser Glu  Leu Thr Gln Asp Pro  Ala Val Ser 
    1205                 1210                 1215             


Val Ala  Leu Gly Gln Thr Val  Arg Ile Thr Cys Gln  Gly Asp Ser 
    1220                 1225                 1230             


Leu Arg  Ser Tyr Tyr Ala Ser  Trp Tyr Gln Gln Lys  Pro Gly Gln 
    1235                 1240                 1245             


Ala Pro  Val Leu Val Ile Tyr  Gly Lys Asn Asn Arg  Pro Ser Gly 
    1250                 1255                 1260             


Ile Pro  Asp Arg Phe Ser Gly  Ser Ser Ser Gly Asn  Thr Ala Ser 
    1265                 1270                 1275             


Leu Thr  Ile Thr Gly Ala Gln  Ala Glu Asp Glu Ala  Asp Tyr Tyr 
    1280                 1285                 1290             


Cys Asn  Ser Arg Asp Ser Ser  Gly Asn His Val Val  Phe Gly Gly 
    1295                 1300                 1305             


Gly Thr  Lys Leu Thr Val Leu  
    1310                 1315 


<210>  61
<211>  1316
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSFDiaF8

<400>  61

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg 
    690                 695                 700                 


Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys 
705                 710                 715                 720 


Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu 
                725                 730                 735     


Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val 
            740                 745                 750         


Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr 
        755                 760                 765             


Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr 
    770                 775                 780                 


Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr 
785                 790                 795                 800 


Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe 
                805                 810                 815     


Glu Cys Lys Lys Pro Gly Gln Lys Ser Ser Ser Ser Gly Ser Ser Ser 
            820                 825                 830         


Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
        835                 840                 845             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    850                 855                 860                 


Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro 
865                 870                 875                 880 


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser 
                885                 890                 895     


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            900                 905                 910         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        915                 920                 925             


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe 
    930                 935                 940                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
945                 950                 955                 960 


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
                965                 970                 975     


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            980                 985                 990         


Met Pro Phe Leu Ala Trp Tyr Gln  Gln Lys Pro Gly Gln  Ala Pro Arg 
        995                 1000                 1005             


Leu Leu  Ile Tyr Gly Ala Ser  Ser Arg Ala Thr Gly  Ile Pro Asp 
    1010                 1015                 1020             


Arg Phe  Ser Gly Ser Gly Ser  Gly Thr Asp Phe Thr  Leu Thr Ile 
    1025                 1030                 1035             


Ser Arg  Leu Glu Pro Glu Asp  Phe Ala Val Tyr Tyr  Cys Gln Gln 
    1040                 1045                 1050             


Met Arg  Gly Arg Pro Pro Thr  Phe Gly Gln Gly Thr  Lys Val Glu 
    1055                 1060                 1065             


Ile Lys  Ser Ser Ser Ser Gly  Ser Ser Ser Ser Gly  Ser Ser Ser 
    1070                 1075                 1080             


Ser Gly  Glu Val Gln Leu Leu  Glu Ser Gly Gly Gly  Leu Val Gln 
    1085                 1090                 1095             


Pro Gly  Gly Ser Leu Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Thr 
    1100                 1105                 1110             


Phe Ser  Leu Phe Thr Met Ser  Trp Val Arg Gln Ala  Pro Gly Lys 
    1115                 1120                 1125             


Gly Leu  Glu Trp Val Ser Ala  Ile Ser Gly Ser Gly  Gly Ser Thr 
    1130                 1135                 1140             


Tyr Tyr  Ala Asp Ser Val Lys  Gly Arg Phe Thr Ile  Ser Arg Asp 
    1145                 1150                 1155             


Asn Ser  Lys Asn Thr Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala 
    1160                 1165                 1170             


Glu Asp  Thr Ala Val Tyr Tyr  Cys Ala Lys Ser Thr  His Leu Tyr 
    1175                 1180                 1185             


Leu Phe  Asp Tyr Trp Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser 
    1190                 1195                 1200             


Gly Gly  Ser Gly Gly Glu Ile  Val Leu Thr Gln Ser  Pro Gly Thr 
    1205                 1210                 1215             


Leu Ser  Leu Ser Pro Gly Glu  Arg Ala Thr Leu Ser  Cys Arg Ala 
    1220                 1225                 1230             


Ser Gln  Ser Val Ser Met Pro  Phe Leu Ala Trp Tyr  Gln Gln Lys 
    1235                 1240                 1245             


Pro Gly  Gln Ala Pro Arg Leu  Leu Ile Tyr Gly Ala  Ser Ser Arg 
    1250                 1255                 1260             


Ala Thr  Gly Ile Pro Asp Arg  Phe Ser Gly Ser Gly  Ser Gly Thr 
    1265                 1270                 1275             


Asp Phe  Thr Leu Thr Ile Ser  Arg Leu Glu Pro Glu  Asp Phe Ala 
    1280                 1285                 1290             


Val Tyr  Tyr Cys Gln Gln Met  Arg Gly Arg Pro Pro  Thr Phe Gly 
    1295                 1300                 1305             


Gln Gly  Thr Lys Val Glu Ile  Lys 
    1310                 1315     


<210>  62
<211>  1292
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaL19IL2GMCSF

<400>  62

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
545                 550                 555                 560 


Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile Val Leu 
                645                 650                 655     


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
            660                 665                 670         


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp 
        675                 680                 685             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala 
    690                 695                 700                 


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                725                 730                 735     


Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly 
            740                 745                 750         


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser 
        755                 760                 765             


Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
    770                 775                 780                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
785                 790                 795                 800 


Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro 
                805                 810                 815     


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr 
            820                 825                 830         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        835                 840                 845             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    850                 855                 860                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr 
865                 870                 875                 880 


Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile 
                885                 890                 895     


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
            900                 905                 910         


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu 
        915                 920                 925             


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
    930                 935                 940                 


Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
945                 950                 955                 960 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
                965                 970                 975     


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr 
            980                 985                 990         


Phe Gly Gln Gly Thr Lys Val Glu  Ile Lys Gly Gly Gly  Gly Ser Gly 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala Pro Thr  Ser Ser Ser 
    1010                 1015                 1020             


Thr Lys  Lys Thr Gln Leu Gln  Leu Glu His Leu Leu  Leu Asp Leu 
    1025                 1030                 1035             


Gln Met  Ile Leu Asn Gly Ile  Asn Asn Tyr Lys Asn  Pro Lys Leu 
    1040                 1045                 1050             


Thr Arg  Met Leu Thr Phe Lys  Phe Tyr Met Pro Lys  Lys Ala Thr 
    1055                 1060                 1065             


Glu Leu  Lys His Leu Gln Cys  Leu Glu Glu Glu Leu  Lys Pro Leu 
    1070                 1075                 1080             


Glu Glu  Val Leu Asn Leu Ala  Gln Ser Lys Asn Phe  His Leu Arg 
    1085                 1090                 1095             


Pro Arg  Asp Leu Ile Ser Asn  Ile Asn Val Ile Val  Leu Glu Leu 
    1100                 1105                 1110             


Lys Gly  Ser Glu Thr Thr Phe  Met Cys Glu Tyr Ala  Asp Glu Thr 
    1115                 1120                 1125             


Ala Thr  Ile Val Glu Phe Leu  Asn Arg Trp Ile Thr  Phe Cys Gln 
    1130                 1135                 1140             


Ser Ile  Ile Ser Thr Leu Thr  Ser Ser Ser Ser Gly  Ser Ser Ser 
    1145                 1150                 1155             


Ser Gly  Ser Ser Ser Ser Gly  Ala Pro Ala Arg Ser  Pro Ser Pro 
    1160                 1165                 1170             


Ser Thr  Gln Pro Trp Glu His  Val Asn Ala Ile Gln  Glu Ala Arg 
    1175                 1180                 1185             


Arg Leu  Leu Asn Leu Ser Arg  Asp Thr Ala Ala Glu  Met Asn Glu 
    1190                 1195                 1200             


Thr Val  Glu Val Ile Ser Glu  Met Phe Asp Leu Gln  Glu Pro Thr 
    1205                 1210                 1215             


Cys Leu  Gln Thr Arg Leu Glu  Leu Tyr Lys Gln Gly  Leu Arg Gly 
    1220                 1225                 1230             


Ser Leu  Thr Lys Leu Lys Gly  Pro Leu Thr Met Met  Ala Ser His 
    1235                 1240                 1245             


Tyr Lys  Gln His Cys Pro Pro  Thr Pro Glu Thr Ser  Cys Ala Thr 
    1250                 1255                 1260             


Gln Ile  Ile Thr Phe Glu Ser  Phe Lys Glu Asn Leu  Lys Asp Phe 
    1265                 1270                 1275             


Leu Leu  Val Ile Pro Phe Asp  Cys Trp Glu Pro Val  Gln Glu 
    1280                 1285                 1290         


<210>  63
<211>  1298
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76IL2GMCSF

<400>  63

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    530                 535                 540                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr 
545                 550                 555                 560 


Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                565                 570                 575     


Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr 
            580                 585                 590         


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
        595                 600                 605             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
            660                 665                 670         


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
        675                 680                 685             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
    690                 695                 700                 


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
705                 710                 715                 720 


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
                725                 730                 735     


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
            740                 745                 750         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu 
    770                 775                 780                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
785                 790                 795                 800 


Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
                805                 810                 815     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His 
            820                 825                 830         


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
        835                 840                 845             


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    850                 855                 860                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser 
865                 870                 875                 880 


Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                885                 890                 895     


Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
            900                 905                 910         


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
        915                 920                 925             


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    930                 935                 940                 


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
945                 950                 955                 960 


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
                965                 970                 975     


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
            980                 985                 990         


Ser Gly Asn His Val Val Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu 
        995                 1000                 1005             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1010                 1015                 1020             


Ala Pro  Thr Ser Ser Ser Thr  Lys Lys Thr Gln Leu  Gln Leu Glu 
    1025                 1030                 1035             


His Leu  Leu Leu Asp Leu Gln  Met Ile Leu Asn Gly  Ile Asn Asn 
    1040                 1045                 1050             


Tyr Lys  Asn Pro Lys Leu Thr  Arg Met Leu Thr Phe  Lys Phe Tyr 
    1055                 1060                 1065             


Met Pro  Lys Lys Ala Thr Glu  Leu Lys His Leu Gln  Cys Leu Glu 
    1070                 1075                 1080             


Glu Glu  Leu Lys Pro Leu Glu  Glu Val Leu Asn Leu  Ala Gln Ser 
    1085                 1090                 1095             


Lys Asn  Phe His Leu Arg Pro  Arg Asp Leu Ile Ser  Asn Ile Asn 
    1100                 1105                 1110             


Val Ile  Val Leu Glu Leu Lys  Gly Ser Glu Thr Thr  Phe Met Cys 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Glu Thr Ala  Thr Ile Val Glu Phe  Leu Asn Arg 
    1130                 1135                 1140             


Trp Ile  Thr Phe Cys Gln Ser  Ile Ile Ser Thr Leu  Thr Ser Ser 
    1145                 1150                 1155             


Ser Ser  Gly Ser Ser Ser Ser  Gly Ser Ser Ser Ser  Gly Ala Pro 
    1160                 1165                 1170             


Ala Arg  Ser Pro Ser Pro Ser  Thr Gln Pro Trp Glu  His Val Asn 
    1175                 1180                 1185             


Ala Ile  Gln Glu Ala Arg Arg  Leu Leu Asn Leu Ser  Arg Asp Thr 
    1190                 1195                 1200             


Ala Ala  Glu Met Asn Glu Thr  Val Glu Val Ile Ser  Glu Met Phe 
    1205                 1210                 1215             


Asp Leu  Gln Glu Pro Thr Cys  Leu Gln Thr Arg Leu  Glu Leu Tyr 
    1220                 1225                 1230             


Lys Gln  Gly Leu Arg Gly Ser  Leu Thr Lys Leu Lys  Gly Pro Leu 
    1235                 1240                 1245             


Thr Met  Met Ala Ser His Tyr  Lys Gln His Cys Pro  Pro Thr Pro 
    1250                 1255                 1260             


Glu Thr  Ser Cys Ala Thr Gln  Ile Ile Thr Phe Glu  Ser Phe Lys 
    1265                 1270                 1275             


Glu Asn  Leu Lys Asp Phe Leu  Leu Val Ile Pro Phe  Asp Cys Trp 
    1280                 1285                 1290             


Glu Pro  Val Gln Glu 
    1295             


<210>  64
<211>  1299
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76F8IL2GMCSF

<400>  64

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    530                 535                 540                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr 
545                 550                 555                 560 


Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                565                 570                 575     


Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr 
            580                 585                 590         


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
        595                 600                 605             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
            660                 665                 670         


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe 
        675                 680                 685             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    690                 695                 700                 


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
                725                 730                 735     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro 
            740                 745                 750         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu 
    770                 775                 780                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
785                 790                 795                 800 


Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg 
                805                 810                 815     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
            820                 825                 830         


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        835                 840                 845             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    850                 855                 860                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu 
865                 870                 875                 880 


Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                885                 890                 895     


Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 
            900                 905                 910         


Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 
        915                 920                 925             


Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    930                 935                 940                 


Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp 
945                 950                 955                 960 


Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 
                965                 970                 975     


Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 
            980                 985                 990         


Ser Ser Gly Asn His Val Val Phe  Gly Gly Gly Thr Lys  Leu Thr Val 
        995                 1000                 1005             


Leu Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Ala  Pro Thr Ser Ser Ser  Thr Lys Lys Thr Gln  Leu Gln Leu 
    1025                 1030                 1035             


Glu His  Leu Leu Leu Asp Leu  Gln Met Ile Leu Asn  Gly Ile Asn 
    1040                 1045                 1050             


Asn Tyr  Lys Asn Pro Lys Leu  Thr Arg Met Leu Thr  Phe Lys Phe 
    1055                 1060                 1065             


Tyr Met  Pro Lys Lys Ala Thr  Glu Leu Lys His Leu  Gln Cys Leu 
    1070                 1075                 1080             


Glu Glu  Glu Leu Lys Pro Leu  Glu Glu Val Leu Asn  Leu Ala Gln 
    1085                 1090                 1095             


Ser Lys  Asn Phe His Leu Arg  Pro Arg Asp Leu Ile  Ser Asn Ile 
    1100                 1105                 1110             


Asn Val  Ile Val Leu Glu Leu  Lys Gly Ser Glu Thr  Thr Phe Met 
    1115                 1120                 1125             


Cys Glu  Tyr Ala Asp Glu Thr  Ala Thr Ile Val Glu  Phe Leu Asn 
    1130                 1135                 1140             


Arg Trp  Ile Thr Phe Cys Gln  Ser Ile Ile Ser Thr  Leu Thr Ser 
    1145                 1150                 1155             


Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ala 
    1160                 1165                 1170             


Pro Ala  Arg Ser Pro Ser Pro  Ser Thr Gln Pro Trp  Glu His Val 
    1175                 1180                 1185             


Asn Ala  Ile Gln Glu Ala Arg  Arg Leu Leu Asn Leu  Ser Arg Asp 
    1190                 1195                 1200             


Thr Ala  Ala Glu Met Asn Glu  Thr Val Glu Val Ile  Ser Glu Met 
    1205                 1210                 1215             


Phe Asp  Leu Gln Glu Pro Thr  Cys Leu Gln Thr Arg  Leu Glu Leu 
    1220                 1225                 1230             


Tyr Lys  Gln Gly Leu Arg Gly  Ser Leu Thr Lys Leu  Lys Gly Pro 
    1235                 1240                 1245             


Leu Thr  Met Met Ala Ser His  Tyr Lys Gln His Cys  Pro Pro Thr 
    1250                 1255                 1260             


Pro Glu  Thr Ser Cys Ala Thr  Gln Ile Ile Thr Phe  Glu Ser Phe 
    1265                 1270                 1275             


Lys Glu  Asn Leu Lys Asp Phe  Leu Leu Val Ile Pro  Phe Asp Cys 
    1280                 1285                 1290             


Trp Glu  Pro Val Gln Glu 
    1295                 


<210>  65
<211>  1299
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaNHS76F8GMCSF

<400>  65

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
    530                 535                 540                 


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
545                 550                 555                 560 


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
                565                 570                 575     


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
            580                 585                 590         


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
        595                 600                 605             


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
    610                 615                 620                 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
625                 630                 635                 640 


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
                645                 650                 655     


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
        675                 680                 685             


Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala 
    690                 695                 700                 


Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg 
705                 710                 715                 720 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser 
                725                 730                 735     


Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
            740                 745                 750         


Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
        755                 760                 765             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys 
    770                 775                 780                 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
785                 790                 795                 800 


Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
                805                 810                 815     


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
            820                 825                 830         


Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        835                 840                 845             


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
    850                 855                 860                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
865                 870                 875                 880 


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg 
                885                 890                 895     


Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser 
            900                 905                 910         


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val 
        915                 920                 925             


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    930                 935                 940                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met 
945                 950                 955                 960 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
                965                 970                 975     


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            980                 985                 990         


Arg Phe Thr Ile Ser Arg Asp Asn  Ser Lys Asn Thr Leu  Tyr Leu Gln 
        995                 1000                 1005             


Met Asn  Ser Leu Arg Ala Glu  Asp Thr Ala Val Tyr  Tyr Cys Ala 
    1010                 1015                 1020             


Lys Ser  Thr His Leu Tyr Leu  Phe Asp Tyr Trp Gly  Gln Gly Thr 
    1025                 1030                 1035             


Leu Val  Thr Val Ser Ser Gly  Gly Ser Gly Gly Ser  Ser Glu Leu 
    1040                 1045                 1050             


Thr Gln  Asp Pro Ala Val Ser  Val Ala Leu Gly Gln  Thr Val Arg 
    1055                 1060                 1065             


Ile Thr  Cys Gln Gly Asp Ser  Leu Arg Ser Tyr Tyr  Ala Ser Trp 
    1070                 1075                 1080             


Tyr Gln  Gln Lys Pro Gly Gln  Ala Pro Val Leu Val  Ile Tyr Gly 
    1085                 1090                 1095             


Lys Asn  Asn Arg Pro Ser Gly  Ile Pro Asp Arg Phe  Ser Gly Ser 
    1100                 1105                 1110             


Ser Ser  Gly Asn Thr Ala Ser  Leu Thr Ile Thr Gly  Ala Gln Ala 
    1115                 1120                 1125             


Glu Asp  Glu Ala Asp Tyr Tyr  Cys Asn Ser Arg Asp  Ser Ser Gly 
    1130                 1135                 1140             


Asn His  Val Val Phe Gly Gly  Gly Thr Lys Leu Thr  Val Leu Ser 
    1145                 1150                 1155             


Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ser Ser Ser  Ser Gly Ala 
    1160                 1165                 1170             


Pro Ala  Arg Ser Pro Ser Pro  Ser Thr Gln Pro Trp  Glu His Val 
    1175                 1180                 1185             


Asn Ala  Ile Gln Glu Ala Arg  Arg Leu Leu Asn Leu  Ser Arg Asp 
    1190                 1195                 1200             


Thr Ala  Ala Glu Met Asn Glu  Thr Val Glu Val Ile  Ser Glu Met 
    1205                 1210                 1215             


Phe Asp  Leu Gln Glu Pro Thr  Cys Leu Gln Thr Arg  Leu Glu Leu 
    1220                 1225                 1230             


Tyr Lys  Gln Gly Leu Arg Gly  Ser Leu Thr Lys Leu  Lys Gly Pro 
    1235                 1240                 1245             


Leu Thr  Met Met Ala Ser His  Tyr Lys Gln His Cys  Pro Pro Thr 
    1250                 1255                 1260             


Pro Glu  Thr Ser Cys Ala Thr  Gln Ile Ile Thr Phe  Glu Ser Phe 
    1265                 1270                 1275             


Lys Glu  Asn Leu Lys Asp Phe  Leu Leu Val Ile Pro  Phe Asp Cys 
    1280                 1285                 1290             


Trp Glu  Pro Val Gln Glu 
    1295                 


<210>  66
<211>  1300
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaF8GMCSF

<400>  66

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
    530                 535                 540                 


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
545                 550                 555                 560 


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
                565                 570                 575     


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
            580                 585                 590         


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
        595                 600                 605             


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
    610                 615                 620                 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
625                 630                 635                 640 


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
                645                 650                 655     


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
        675                 680                 685             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    690                 695                 700                 


Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg Gln 
705                 710                 715                 720 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly 
                725                 730                 735     


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            740                 745                 750         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        755                 760                 765             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu Tyr 
    770                 775                 780                 


Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
785                 790                 795                 800 


Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
                805                 810                 815     


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
            820                 825                 830         


Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        835                 840                 845             


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
    850                 855                 860                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
865                 870                 875                 880 


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met 
                885                 890                 895     


Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            900                 905                 910         


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu 
        915                 920                 925             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    930                 935                 940                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr 
945                 950                 955                 960 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                965                 970                 975     


Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
            980                 985                 990         


Gly Arg Phe Thr Ile Ser Arg Asp  Asn Ser Lys Asn Thr  Leu Tyr Leu 
        995                 1000                 1005             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1010                 1015                 1020             


Ala Lys  Ser Thr His Leu Tyr  Leu Phe Asp Tyr Trp  Gly Gln Gly 
    1025                 1030                 1035             


Thr Leu  Val Thr Val Ser Ser  Gly Gly Ser Gly Gly  Glu Ile Val 
    1040                 1045                 1050             


Leu Thr  Gln Ser Pro Gly Thr  Leu Ser Leu Ser Pro  Gly Glu Arg 
    1055                 1060                 1065             


Ala Thr  Leu Ser Cys Arg Ala  Ser Gln Ser Val Ser  Met Pro Phe 
    1070                 1075                 1080             


Leu Ala  Trp Tyr Gln Gln Lys  Pro Gly Gln Ala Pro  Arg Leu Leu 
    1085                 1090                 1095             


Ile Tyr  Gly Ala Ser Ser Arg  Ala Thr Gly Ile Pro  Asp Arg Phe 
    1100                 1105                 1110             


Ser Gly  Ser Gly Ser Gly Thr  Asp Phe Thr Leu Thr  Ile Ser Arg 
    1115                 1120                 1125             


Leu Glu  Pro Glu Asp Phe Ala  Val Tyr Tyr Cys Gln  Gln Met Arg 
    1130                 1135                 1140             


Gly Arg  Pro Pro Thr Phe Gly  Gln Gly Thr Lys Val  Glu Ile Lys 
    1145                 1150                 1155             


Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly Ser Ser  Ser Ser Gly 
    1160                 1165                 1170             


Ala Pro  Ala Arg Ser Pro Ser  Pro Ser Thr Gln Pro  Trp Glu His 
    1175                 1180                 1185             


Val Asn  Ala Ile Gln Glu Ala  Arg Arg Leu Leu Asn  Leu Ser Arg 
    1190                 1195                 1200             


Asp Thr  Ala Ala Glu Met Asn  Glu Thr Val Glu Val  Ile Ser Glu 
    1205                 1210                 1215             


Met Phe  Asp Leu Gln Glu Pro  Thr Cys Leu Gln Thr  Arg Leu Glu 
    1220                 1225                 1230             


Leu Tyr  Lys Gln Gly Leu Arg  Gly Ser Leu Thr Lys  Leu Lys Gly 
    1235                 1240                 1245             


Pro Leu  Thr Met Met Ala Ser  His Tyr Lys Gln His  Cys Pro Pro 
    1250                 1255                 1260             


Thr Pro  Glu Thr Ser Cys Ala  Thr Gln Ile Ile Thr  Phe Glu Ser 
    1265                 1270                 1275             


Phe Lys  Glu Asn Leu Lys Asp  Phe Leu Leu Val Ile  Pro Phe Asp 
    1280                 1285                 1290             


Cys Trp  Glu Pro Val Gln Glu  
    1295                 1300 


<210>  67
<211>  1292
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaL19GMCSFIL2

<400>  67

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
545                 550                 555                 560 


Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile Val Leu 
                645                 650                 655     


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
            660                 665                 670         


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp 
        675                 680                 685             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala 
    690                 695                 700                 


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                725                 730                 735     


Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly 
            740                 745                 750         


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser 
        755                 760                 765             


Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
    770                 775                 780                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
785                 790                 795                 800 


Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro 
                805                 810                 815     


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr 
            820                 825                 830         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        835                 840                 845             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    850                 855                 860                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr 
865                 870                 875                 880 


Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Ser Gly Gly Glu Ile 
                885                 890                 895     


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
            900                 905                 910         


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu 
        915                 920                 925             


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
    930                 935                 940                 


Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
945                 950                 955                 960 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
                965                 970                 975     


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr 
            980                 985                 990         


Phe Gly Gln Gly Thr Lys Val Glu  Ile Lys Gly Gly Gly  Gly Ser Gly 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala Pro Ala  Arg Ser Pro 
    1010                 1015                 1020             


Ser Pro  Ser Thr Gln Pro Trp  Glu His Val Asn Ala  Ile Gln Glu 
    1025                 1030                 1035             


Ala Arg  Arg Leu Leu Asn Leu  Ser Arg Asp Thr Ala  Ala Glu Met 
    1040                 1045                 1050             


Asn Glu  Thr Val Glu Val Ile  Ser Glu Met Phe Asp  Leu Gln Glu 
    1055                 1060                 1065             


Pro Thr  Cys Leu Gln Thr Arg  Leu Glu Leu Tyr Lys  Gln Gly Leu 
    1070                 1075                 1080             


Arg Gly  Ser Leu Thr Lys Leu  Lys Gly Pro Leu Thr  Met Met Ala 
    1085                 1090                 1095             


Ser His  Tyr Lys Gln His Cys  Pro Pro Thr Pro Glu  Thr Ser Cys 
    1100                 1105                 1110             


Ala Thr  Gln Ile Ile Thr Phe  Glu Ser Phe Lys Glu  Asn Leu Lys 
    1115                 1120                 1125             


Asp Phe  Leu Leu Val Ile Pro  Phe Asp Cys Trp Glu  Pro Val Gln 
    1130                 1135                 1140             


Glu Ser  Ser Ser Ser Gly Ser  Ser Ser Ser Gly Ser  Ser Ser Ser 
    1145                 1150                 1155             


Gly Ala  Pro Thr Ser Ser Ser  Thr Lys Lys Thr Gln  Leu Gln Leu 
    1160                 1165                 1170             


Glu His  Leu Leu Leu Asp Leu  Gln Met Ile Leu Asn  Gly Ile Asn 
    1175                 1180                 1185             


Asn Tyr  Lys Asn Pro Lys Leu  Thr Arg Met Leu Thr  Phe Lys Phe 
    1190                 1195                 1200             


Tyr Met  Pro Lys Lys Ala Thr  Glu Leu Lys His Leu  Gln Cys Leu 
    1205                 1210                 1215             


Glu Glu  Glu Leu Lys Pro Leu  Glu Glu Val Leu Asn  Leu Ala Gln 
    1220                 1225                 1230             


Ser Lys  Asn Phe His Leu Arg  Pro Arg Asp Leu Ile  Ser Asn Ile 
    1235                 1240                 1245             


Asn Val  Ile Val Leu Glu Leu  Lys Gly Ser Glu Thr  Thr Phe Met 
    1250                 1255                 1260             


Cys Glu  Tyr Ala Asp Glu Thr  Ala Thr Ile Val Glu  Phe Leu Asn 
    1265                 1270                 1275             


Arg Trp  Ile Thr Phe Cys Gln  Ser Ile Ile Ser Thr  Leu Thr 
    1280                 1285                 1290         


<210>  68
<211>  1298
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76GMCSFIL2

<400>  68

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    530                 535                 540                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr 
545                 550                 555                 560 


Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                565                 570                 575     


Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr 
            580                 585                 590         


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
        595                 600                 605             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
            660                 665                 670         


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
        675                 680                 685             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
    690                 695                 700                 


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
705                 710                 715                 720 


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
                725                 730                 735     


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
            740                 745                 750         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Gln Val Gln Leu Gln Glu 
    770                 775                 780                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
785                 790                 795                 800 


Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
                805                 810                 815     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His 
            820                 825                 830         


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
        835                 840                 845             


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    850                 855                 860                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser 
865                 870                 875                 880 


Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                885                 890                 895     


Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
            900                 905                 910         


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
        915                 920                 925             


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    930                 935                 940                 


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
945                 950                 955                 960 


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
                965                 970                 975     


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
            980                 985                 990         


Ser Gly Asn His Val Val Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu 
        995                 1000                 1005             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1010                 1015                 1020             


Ala Pro  Ala Arg Ser Pro Ser  Pro Ser Thr Gln Pro  Trp Glu His 
    1025                 1030                 1035             


Val Asn  Ala Ile Gln Glu Ala  Arg Arg Leu Leu Asn  Leu Ser Arg 
    1040                 1045                 1050             


Asp Thr  Ala Ala Glu Met Asn  Glu Thr Val Glu Val  Ile Ser Glu 
    1055                 1060                 1065             


Met Phe  Asp Leu Gln Glu Pro  Thr Cys Leu Gln Thr  Arg Leu Glu 
    1070                 1075                 1080             


Leu Tyr  Lys Gln Gly Leu Arg  Gly Ser Leu Thr Lys  Leu Lys Gly 
    1085                 1090                 1095             


Pro Leu  Thr Met Met Ala Ser  His Tyr Lys Gln His  Cys Pro Pro 
    1100                 1105                 1110             


Thr Pro  Glu Thr Ser Cys Ala  Thr Gln Ile Ile Thr  Phe Glu Ser 
    1115                 1120                 1125             


Phe Lys  Glu Asn Leu Lys Asp  Phe Leu Leu Val Ile  Pro Phe Asp 
    1130                 1135                 1140             


Cys Trp  Glu Pro Val Gln Glu  Ser Ser Ser Ser Gly  Ser Ser Ser 
    1145                 1150                 1155             


Ser Gly  Ser Ser Ser Ser Gly  Ala Pro Thr Ser Ser  Ser Thr Lys 
    1160                 1165                 1170             


Lys Thr  Gln Leu Gln Leu Glu  His Leu Leu Leu Asp  Leu Gln Met 
    1175                 1180                 1185             


Ile Leu  Asn Gly Ile Asn Asn  Tyr Lys Asn Pro Lys  Leu Thr Arg 
    1190                 1195                 1200             


Met Leu  Thr Phe Lys Phe Tyr  Met Pro Lys Lys Ala  Thr Glu Leu 
    1205                 1210                 1215             


Lys His  Leu Gln Cys Leu Glu  Glu Glu Leu Lys Pro  Leu Glu Glu 
    1220                 1225                 1230             


Val Leu  Asn Leu Ala Gln Ser  Lys Asn Phe His Leu  Arg Pro Arg 
    1235                 1240                 1245             


Asp Leu  Ile Ser Asn Ile Asn  Val Ile Val Leu Glu  Leu Lys Gly 
    1250                 1255                 1260             


Ser Glu  Thr Thr Phe Met Cys  Glu Tyr Ala Asp Glu  Thr Ala Thr 
    1265                 1270                 1275             


Ile Val  Glu Phe Leu Asn Arg  Trp Ile Thr Phe Cys  Gln Ser Ile 
    1280                 1285                 1290             


Ile Ser  Thr Leu Thr 
    1295             


<210>  69
<211>  1299
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76F8GMCSFIL2

<400>  69

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    530                 535                 540                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr 
545                 550                 555                 560 


Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                565                 570                 575     


Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr 
            580                 585                 590         


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
        595                 600                 605             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser Lys Phe Asp Tyr Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
            660                 665                 670         


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe 
        675                 680                 685             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    690                 695                 700                 


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
                725                 730                 735     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro 
            740                 745                 750         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Ser Gly 
        755                 760                 765             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu Val Gln Leu Leu Glu 
    770                 775                 780                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
785                 790                 795                 800 


Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val Arg 
                805                 810                 815     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
            820                 825                 830         


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        835                 840                 845             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    850                 855                 860                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His Leu 
865                 870                 875                 880 


Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                885                 890                 895     


Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 
            900                 905                 910         


Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 
        915                 920                 925             


Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    930                 935                 940                 


Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp 
945                 950                 955                 960 


Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 
                965                 970                 975     


Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp 
            980                 985                 990         


Ser Ser Gly Asn His Val Val Phe  Gly Gly Gly Thr Lys  Leu Thr Val 
        995                 1000                 1005             


Leu Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Ala  Pro Ala Arg Ser Pro  Ser Pro Ser Thr Gln  Pro Trp Glu 
    1025                 1030                 1035             


His Val  Asn Ala Ile Gln Glu  Ala Arg Arg Leu Leu  Asn Leu Ser 
    1040                 1045                 1050             


Arg Asp  Thr Ala Ala Glu Met  Asn Glu Thr Val Glu  Val Ile Ser 
    1055                 1060                 1065             


Glu Met  Phe Asp Leu Gln Glu  Pro Thr Cys Leu Gln  Thr Arg Leu 
    1070                 1075                 1080             


Glu Leu  Tyr Lys Gln Gly Leu  Arg Gly Ser Leu Thr  Lys Leu Lys 
    1085                 1090                 1095             


Gly Pro  Leu Thr Met Met Ala  Ser His Tyr Lys Gln  His Cys Pro 
    1100                 1105                 1110             


Pro Thr  Pro Glu Thr Ser Cys  Ala Thr Gln Ile Ile  Thr Phe Glu 
    1115                 1120                 1125             


Ser Phe  Lys Glu Asn Leu Lys  Asp Phe Leu Leu Val  Ile Pro Phe 
    1130                 1135                 1140             


Asp Cys  Trp Glu Pro Val Gln  Glu Ser Ser Ser Ser  Gly Ser Ser 
    1145                 1150                 1155             


Ser Ser  Gly Ser Ser Ser Ser  Gly Ala Pro Thr Ser  Ser Ser Thr 
    1160                 1165                 1170             


Lys Lys  Thr Gln Leu Gln Leu  Glu His Leu Leu Leu  Asp Leu Gln 
    1175                 1180                 1185             


Met Ile  Leu Asn Gly Ile Asn  Asn Tyr Lys Asn Pro  Lys Leu Thr 
    1190                 1195                 1200             


Arg Met  Leu Thr Phe Lys Phe  Tyr Met Pro Lys Lys  Ala Thr Glu 
    1205                 1210                 1215             


Leu Lys  His Leu Gln Cys Leu  Glu Glu Glu Leu Lys  Pro Leu Glu 
    1220                 1225                 1230             


Glu Val  Leu Asn Leu Ala Gln  Ser Lys Asn Phe His  Leu Arg Pro 
    1235                 1240                 1245             


Arg Asp  Leu Ile Ser Asn Ile  Asn Val Ile Val Leu  Glu Leu Lys 
    1250                 1255                 1260             


Gly Ser  Glu Thr Thr Phe Met  Cys Glu Tyr Ala Asp  Glu Thr Ala 
    1265                 1270                 1275             


Thr Ile  Val Glu Phe Leu Asn  Arg Trp Ile Thr Phe  Cys Gln Ser 
    1280                 1285                 1290             


Ile Ile  Ser Thr Leu Thr 
    1295                 


<210>  70
<211>  1316
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaNHS76F8GMCSF-Thr

<400>  70

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         


Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
    530                 535                 540                 


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
545                 550                 555                 560 


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
                565                 570                 575     


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
            580                 585                 590         


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
        595                 600                 605             


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
    610                 615                 620                 


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
625                 630                 635                 640 


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
                645                 650                 655     


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
            660                 665                 670         


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly 
        675                 680                 685             


Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    690                 695                 700                 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
705                 710                 715                 720 


Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp 
                725                 730                 735     


Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser 
            740                 745                 750         


Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
        755                 760                 765             


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
    770                 775                 780                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
785                 790                 795                 800 


Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                805                 810                 815     


Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
            820                 825                 830         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        835                 840                 845             


Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
    850                 855                 860                 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
865                 870                 875                 880 


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                885                 890                 895     


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            900                 905                 910         


Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
        915                 920                 925             


Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
    930                 935                 940                 


Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
945                 950                 955                 960 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                965                 970                 975     


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            980                 985                 990         


Trp Val Ser Ala Ile Ser Gly Ser  Gly Gly Ser Thr Tyr  Tyr Ala Asp 
        995                 1000                 1005             


Ser Val  Lys Gly Arg Phe Thr  Ile Ser Arg Asp Asn  Ser Lys Asn 
    1010                 1015                 1020             


Thr Leu  Tyr Leu Gln Met Asn  Ser Leu Arg Ala Glu  Asp Thr Ala 
    1025                 1030                 1035             


Val Tyr  Tyr Cys Ala Lys Ser  Thr His Leu Tyr Leu  Phe Asp Tyr 
    1040                 1045                 1050             


Trp Gly  Gln Gly Thr Leu Val  Thr Val Ser Ser Gly  Gly Ser Gly 
    1055                 1060                 1065             


Gly Ser  Ser Glu Leu Thr Gln  Asp Pro Ala Val Ser  Val Ala Leu 
    1070                 1075                 1080             


Gly Gln  Thr Val Arg Ile Thr  Cys Gln Gly Asp Ser  Leu Arg Ser 
    1085                 1090                 1095             


Tyr Tyr  Ala Ser Trp Tyr Gln  Gln Lys Pro Gly Gln  Ala Pro Val 
    1100                 1105                 1110             


Leu Val  Ile Tyr Gly Lys Asn  Asn Arg Pro Ser Gly  Ile Pro Asp 
    1115                 1120                 1125             


Arg Phe  Ser Gly Ser Ser Ser  Gly Asn Thr Ala Ser  Leu Thr Ile 
    1130                 1135                 1140             


Thr Gly  Ala Gln Ala Glu Asp  Glu Ala Asp Tyr Tyr  Cys Asn Ser 
    1145                 1150                 1155             


Arg Asp  Ser Ser Gly Asn His  Val Val Phe Gly Gly  Gly Thr Lys 
    1160                 1165                 1170             


Leu Thr  Val Leu Ser Ser Ser  Ser Gly Leu Val Pro  Arg Gly Ser 
    1175                 1180                 1185             


Ser Ser  Ser Gly Ala Pro Thr  Arg Ser Pro Ile Thr  Val Thr Arg 
    1190                 1195                 1200             


Pro Trp  Lys His Val Glu Ala  Ile Lys Glu Ala Leu  Asn Leu Leu 
    1205                 1210                 1215             


Asp Asp  Met Pro Val Thr Leu  Asn Glu Glu Val Glu  Val Val Ser 
    1220                 1225                 1230             


Asn Glu  Phe Ser Phe Lys Lys  Leu Thr Cys Val Gln  Thr Arg Leu 
    1235                 1240                 1245             


Lys Ile  Phe Glu Gln Gly Leu  Arg Gly Asn Phe Thr  Lys Leu Lys 
    1250                 1255                 1260             


Gly Ala  Leu Asn Met Thr Ala  Ser Tyr Tyr Gln Thr  Tyr Cys Pro 
    1265                 1270                 1275             


Pro Thr  Pro Glu Thr Asp Cys  Glu Thr Gln Val Thr  Thr Tyr Ala 
    1280                 1285                 1290             


Asp Phe  Ile Asp Ser Leu Lys  Thr Phe Leu Thr Asp  Ile Pro Phe 
    1295                 1300                 1305             


Glu Cys  Lys Lys Pro Gly Gln  Lys 
    1310                 1315     


<210>  71
<211>  1300
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaNHS76F8GMCSF-Thr

<400>  71

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
    530                 535                 540                 


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
545                 550                 555                 560 


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
                565                 570                 575     


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
            580                 585                 590         


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
        595                 600                 605             


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
    610                 615                 620                 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
625                 630                 635                 640 


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
                645                 650                 655     


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Leu 
            660                 665                 670         


Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        675                 680                 685             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    690                 695                 700                 


Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
705                 710                 715                 720 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His 
                725                 730                 735     


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
            740                 745                 750         


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
        755                 760                 765             


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Trp Ser 
    770                 775                 780                 


Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
785                 790                 795                 800 


Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
                805                 810                 815     


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
            820                 825                 830         


Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        835                 840                 845             


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
    850                 855                 860                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
865                 870                 875                 880 


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met 
                885                 890                 895     


Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            900                 905                 910         


Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Glu 
        915                 920                 925             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    930                 935                 940                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr 
945                 950                 955                 960 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                965                 970                 975     


Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
            980                 985                 990         


Gly Arg Phe Thr Ile Ser Arg Asp  Asn Ser Lys Asn Thr  Leu Tyr Leu 
        995                 1000                 1005             


Gln Met  Asn Ser Leu Arg Ala  Glu Asp Thr Ala Val  Tyr Tyr Cys 
    1010                 1015                 1020             


Ala Lys  Ser Thr His Leu Tyr  Leu Phe Asp Tyr Trp  Gly Gln Gly 
    1025                 1030                 1035             


Thr Leu  Val Thr Val Ser Ser  Gly Gly Ser Gly Gly  Ser Ser Glu 
    1040                 1045                 1050             


Leu Thr  Gln Asp Pro Ala Val  Ser Val Ala Leu Gly  Gln Thr Val 
    1055                 1060                 1065             


Arg Ile  Thr Cys Gln Gly Asp  Ser Leu Arg Ser Tyr  Tyr Ala Ser 
    1070                 1075                 1080             


Trp Tyr  Gln Gln Lys Pro Gly  Gln Ala Pro Val Leu  Val Ile Tyr 
    1085                 1090                 1095             


Gly Lys  Asn Asn Arg Pro Ser  Gly Ile Pro Asp Arg  Phe Ser Gly 
    1100                 1105                 1110             


Ser Ser  Ser Gly Asn Thr Ala  Ser Leu Thr Ile Thr  Gly Ala Gln 
    1115                 1120                 1125             


Ala Glu  Asp Glu Ala Asp Tyr  Tyr Cys Asn Ser Arg  Asp Ser Ser 
    1130                 1135                 1140             


Gly Asn  His Val Val Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu 
    1145                 1150                 1155             


Ser Ser  Ser Ser Gly Leu Val  Pro Arg Gly Ser Ser  Ser Ser Gly 
    1160                 1165                 1170             


Ala Pro  Ala Arg Ser Pro Ser  Pro Ser Thr Gln Pro  Trp Glu His 
    1175                 1180                 1185             


Val Asn  Ala Ile Gln Glu Ala  Arg Arg Leu Leu Asn  Leu Ser Arg 
    1190                 1195                 1200             


Asp Thr  Ala Ala Glu Met Asn  Glu Thr Val Glu Val  Ile Ser Glu 
    1205                 1210                 1215             


Met Phe  Asp Leu Gln Glu Pro  Thr Cys Leu Gln Thr  Arg Leu Glu 
    1220                 1225                 1230             


Leu Tyr  Lys Gln Gly Leu Arg  Gly Ser Leu Thr Lys  Leu Lys Gly 
    1235                 1240                 1245             


Pro Leu  Thr Met Met Ala Ser  His Tyr Lys Gln His  Cys Pro Pro 
    1250                 1255                 1260             


Thr Pro  Glu Thr Ser Cys Ala  Thr Gln Ile Ile Thr  Phe Glu Ser 
    1265                 1270                 1275             


Phe Lys  Glu Asn Leu Lys Asp  Phe Leu Leu Val Ile  Pro Phe Asp 
    1280                 1285                 1290             


Cys Trp  Glu Pro Val Gln Glu  
    1295                 1300 


<210>  72
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ˫ںϵ׵ĵһmIL12aIL2

<400>  72

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
                245                 250                 255     


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
            260                 265                 270         


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
        275                 280                 285             


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
    290                 295                 300                 


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
305                 310                 315                 320 


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
                325                 330                 335     


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
            340                 345                 350         


Ser Thr Ser Pro Gln 
        355         


<210>  73
<211>  2472
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSF

<400>  73
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa     2160

gaagccctga acctcctgga tgacatgcct gtcacgttga atgaagaggt agaagtcgtc     2220

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag     2280

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac     2340

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat     2400

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa     2460

ccaggccaaa aa                                                         2472


<210>  74
<211>  2412
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL7GMCSF

<400>  74
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga gtgccacatt     1620

aaagacaaag aaggtaaagc atatgagagt gtactgatga tcagcatcga tgaattggac     1680

aaaatgacag gaactgatag taattgcccg aataatgaac caaacttttt tagaaaacat     1740

gtatgtgatg atacaaagga agctgctttt ctaaatcgtg ctgctcgcaa gttgaagcaa     1800

tttcttaaaa tgaatatcag tgaagaattc aatgtccact tactaacagt atcacaaggc     1860

acacaaacac tggtgaactg cacaagtaag gaagaaaaaa acgtaaagga acagaaaaag     1920

aatgatgcat gtttcctaaa gagactactg agagaaataa aaacttgttg gaataaaatt     1980

ttgaagggca gtataggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2040

gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa     2100

gaagccctga acctcctgga tgacatgcct gtcacgttga atgaagaggt agaagtcgtc     2160

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag     2220

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac     2280

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat     2340

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa     2400

ccaggccaaa aa                                                         2412


<210>  75
<211>  2424
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL15GMCSF

<400>  75
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgg cattcatgtc     1620

ttcattttgg gctgtgtcag tgtaggtctc cctaaaacag aggccaactg gatagatgta     1680

agatatgacc tggagaaaat tgaaagcctt attcaatcta ttcatattga caccacttta     1740

tacactgaca gtgactttca tcccagttgc aaagttactg caatgaactg ctttctcctg     1800

gaattgcagg ttattttaca tgagtacagt aacatgactc ttaatgaaac agtaagaaac     1860

gtgctctacc ttgcaaacag cactctgtct tctaacaaga atgtagcaga atctggctgc     1920

aaggaatgtg aggagctgga ggagaaaacc ttcacagagt ttttgcaaag ctttatacgc     1980

attgtccaaa tgttcatcaa cacgtccggc ggagggggtt caggtggggg cgggagcgga     2040

ggtggcggat cggcacccac ccgctcaccc atcactgtca cccggccttg gaagcatgta     2100

gaggccatca aagaagccct gaacctcctg gatgacatgc ctgtcacgtt gaatgaagag     2160

gtagaagtcg tctctaacga gttctccttc aagaagctaa catgtgtgca gacccgcctg     2220

aagatattcg agcagggtct acggggcaat ttcaccaaac tcaagggcgc cttgaacatg     2280

acagccagct actaccagac atactgcccc ccaactccgg aaacggactg tgaaacacaa     2340

gttaccacct atgcggattt catagacagc cttaaaacct ttctgactga tatccccttt     2400

gaatgcaaaa aaccaggcca aaaa                                            2424


<210>  76
<211>  2412
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL21GMCSF

<400>  76
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcca taaatcaagc     1620

ccccaagggc cagatcgcct cctgattaga cttcgtcacc ttattgacat tgttgaacag     1680

ctgaaaatct atgaaaatga cttggatcct gaacttctat cagctccaca agatgtaaag     1740

gggcactgtg agcatgcagc ttttgcctgt tttcagaagg ccaaactcaa gccatcaaac     1800

cctggaaaca ataagacatt catcattgac ctcgtggccc agctcaggag gaggctgcct     1860

gccaggaggg gaggaaagaa acagaagcac atagctaaat gcccttcctg tgattcgtat     1920

gagaaaagga cacccaaaga attcctagaa agactaaaat ggctccttca aaagatgatt     1980

catcagcatc tctccggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2040

gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa     2100

gaagccctga acctcctgga tgacatgcct gtcacgttga atgaagaggt agaagtcgtc     2160

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag     2220

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac     2280

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat     2340

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa     2400

ccaggccaaa aa                                                         2412


<210>  77
<211>  2718
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2FLT3L

<400>  77
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gggacacctg actgttactt cagccacagt cccatctcct ccaacttcaa agtgaagttt     2160

agagagttga ctgaccacct gcttaaagat tacccagtca ctgtggccgt caatcttcag     2220

gacgagaagc actgcaaggc cttgtggagc ctcttcctag cccagcgctg gatagagcaa     2280

ctgaagactg tggcagggtc taagatgcaa acgcttctgg aggacgtcaa caccgagata     2340

cattttgtca cctcatgtac cttccagccc ctaccagaat gtctgcgatt cgtccagacc     2400

aacatctccc acctcctgaa ggacacctgc acacagctgc ttgctctgaa gccctgtatc     2460

gggaaggcct gccagaattt ctctcggtgc ctggaggtgc agtgccagcc ggactcctcc     2520

accctgctgc ccccaaggag tcccatagcc ctagaagcca cggagctccc agagcctcgg     2580

cccaggcagc tgttgctcct gctgctgctg ctgctgcctc tcacactggt gctgctggca     2640

gccgcctggg gccttcgctg gcaaagggca agaaggaggg gggagctcca ccctggggtg     2700

cccctcccct cccatccc                                                   2718


<210>  78
<211>  2658
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL7FLT3L

<400>  78
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga gtgccacatt     1620

aaagacaaag aaggtaaagc atatgagagt gtactgatga tcagcatcga tgaattggac     1680

aaaatgacag gaactgatag taattgcccg aataatgaac caaacttttt tagaaaacat     1740

gtatgtgatg atacaaagga agctgctttt ctaaatcgtg ctgctcgcaa gttgaagcaa     1800

tttcttaaaa tgaatatcag tgaagaattc aatgtccact tactaacagt atcacaaggc     1860

acacaaacac tggtgaactg cacaagtaag gaagaaaaaa acgtaaagga acagaaaaag     1920

aatgatgcat gtttcctaaa gagactactg agagaaataa aaacttgttg gaataaaatt     1980

ttgaagggca gtataggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2040

gggacacctg actgttactt cagccacagt cccatctcct ccaacttcaa agtgaagttt     2100

agagagttga ctgaccacct gcttaaagat tacccagtca ctgtggccgt caatcttcag     2160

gacgagaagc actgcaaggc cttgtggagc ctcttcctag cccagcgctg gatagagcaa     2220

ctgaagactg tggcagggtc taagatgcaa acgcttctgg aggacgtcaa caccgagata     2280

cattttgtca cctcatgtac cttccagccc ctaccagaat gtctgcgatt cgtccagacc     2340

aacatctccc acctcctgaa ggacacctgc acacagctgc ttgctctgaa gccctgtatc     2400

gggaaggcct gccagaattt ctctcggtgc ctggaggtgc agtgccagcc ggactcctcc     2460

accctgctgc ccccaaggag tcccatagcc ctagaagcca cggagctccc agagcctcgg     2520

cccaggcagc tgttgctcct gctgctgctg ctgctgcctc tcacactggt gctgctggca     2580

gccgcctggg gccttcgctg gcaaagggca agaaggaggg gggagctcca ccctggggtg     2640

cccctcccct cccatccc                                                   2658


<210>  79
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL15FLT3L

<400>  79
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgg cattcatgtc     1620

ttcattttgg gctgtgtcag tgtaggtctc cctaaaacag aggccaactg gatagatgta     1680

agatatgacc tggagaaaat tgaaagcctt attcaatcta ttcatattga caccacttta     1740

tacactgaca gtgactttca tcccagttgc aaagttactg caatgaactg ctttctcctg     1800

gaattgcagg ttattttaca tgagtacagt aacatgactc ttaatgaaac agtaagaaac     1860

gtgctctacc ttgcaaacag cactctgtct tctaacaaga atgtagcaga atctggctgc     1920

aaggaatgtg aggagctgga ggagaaaacc ttcacagagt ttttgcaaag ctttatacgc     1980

attgtccaaa tgttcatcaa cacgtccggc ggagggggtt caggtggggg cgggagcgga     2040

ggtggcggat cggggacacc tgactgttac ttcagccaca gtcccatctc ctccaacttc     2100

aaagtgaagt ttagagagtt gactgaccac ctgcttaaag attacccagt cactgtggcc     2160

gtcaatcttc aggacgagaa gcactgcaag gccttgtgga gcctcttcct agcccagcgc     2220

tggatagagc aactgaagac tgtggcaggg tctaagatgc aaacgcttct ggaggacgtc     2280

aacaccgaga tacattttgt cacctcatgt accttccagc ccctaccaga atgtctgcga     2340

ttcgtccaga ccaacatctc ccacctcctg aaggacacct gcacacagct gcttgctctg     2400

aagccctgta tcgggaaggc ctgccagaat ttctctcggt gcctggaggt gcagtgccag     2460

ccggactcct ccaccctgct gcccccaagg agtcccatag ccctagaagc cacggagctc     2520

ccagagcctc ggcccaggca gctgttgctc ctgctgctgc tgctgctgcc tctcacactg     2580

gtgctgctgg cagccgcctg gggccttcgc tggcaaaggg caagaaggag gggggagctc     2640

caccctgggg tgcccctccc ctcccatccc                                      2670


<210>  80
<211>  2658
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL21FLT3L

<400>  80
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcca taaatcaagc     1620

ccccaagggc cagatcgcct cctgattaga cttcgtcacc ttattgacat tgttgaacag     1680

ctgaaaatct atgaaaatga cttggatcct gaacttctat cagctccaca agatgtaaag     1740

gggcactgtg agcatgcagc ttttgcctgt tttcagaagg ccaaactcaa gccatcaaac     1800

cctggaaaca ataagacatt catcattgac ctcgtggccc agctcaggag gaggctgcct     1860

gccaggaggg gaggaaagaa acagaagcac atagctaaat gcccttcctg tgattcgtat     1920

gagaaaagga cacccaaaga attcctagaa agactaaaat ggctccttca aaagatgatt     1980

catcagcatc tctccggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2040

gggacacctg actgttactt cagccacagt cccatctcct ccaacttcaa agtgaagttt     2100

agagagttga ctgaccacct gcttaaagat tacccagtca ctgtggccgt caatcttcag     2160

gacgagaagc actgcaaggc cttgtggagc ctcttcctag cccagcgctg gatagagcaa     2220

ctgaagactg tggcagggtc taagatgcaa acgcttctgg aggacgtcaa caccgagata     2280

cattttgtca cctcatgtac cttccagccc ctaccagaat gtctgcgatt cgtccagacc     2340

aacatctccc acctcctgaa ggacacctgc acacagctgc ttgctctgaa gccctgtatc     2400

gggaaggcct gccagaattt ctctcggtgc ctggaggtgc agtgccagcc ggactcctcc     2460

accctgctgc ccccaaggag tcccatagcc ctagaagcca cggagctccc agagcctcgg     2520

cccaggcagc tgttgctcct gctgctgctg ctgctgcctc tcacactggt gctgctggca     2580

gccgcctggg gccttcgctg gcaaagggca agaaggaggg gggagctcca ccctggggtg     2640

cccctcccct cccatccc                                                   2658


<210>  81
<211>  2472
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aGMCSFIL2

<400>  81
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacccgc     1620

tcacccatca ctgtcacccg gccttggaag catgtagagg ccatcaaaga agccctgaac     1680

ctcctggatg acatgcctgt cacgttgaat gaagaggtag aagtcgtctc taacgagttc     1740

tccttcaaga agctaacatg tgtgcagacc cgcctgaaga tattcgagca gggtctacgg     1800

ggcaatttca ccaaactcaa gggcgccttg aacatgacag ccagctacta ccagacatac     1860

tgccccccaa ctccggaaac ggactgtgaa acacaagtta ccacctatgc ggatttcata     1920

gacagcctta aaacctttct gactgatatc ccctttgaat gcaaaaaacc aggccaaaaa     1980

ggcggagggg gttcaggtgg gggcgggagc ggaggtggcg gatcggcacc cacttcaagc     2040

tccacttcaa gctctacagc ggaagcacag cagcagcagc agcagcagca gcagcagcag     2100

cagcacctgg agcagctgtt gatggaccta caggagctcc tgagcaggat ggagaattac     2160

aggaacctga aactccccag gatgctcacc ttcaaatttt acttgcccaa gcaggccaca     2220

gaattgaaag atcttcagtg cctagaagat gaacttggac ctctgcggca tgttctggat     2280

ttgactcaaa gcaaaagctt tcaattggaa gatgctgaga atttcatcag caatatcaga     2340

gtaactgttg taaaactaaa gggctctgac aacacatttg agtgccaatt cgatgatgag     2400

tcagcaactg tggtggactt tctgaggaga tggatagcct tctgtcaaag catcatctca     2460

acaagccctc aa                                                         2472


<210>  82
<211>  2424
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2GMCSF

<400>  82
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg cacctacttc aagttctaca     1620

aagaaaacac agctacaact ggagcattta ctgctggatt tacagatgat tttgaatgga     1680

attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt ttacatgccc     1740

aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa acctctggag     1800

gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga cttaatcagc     1860

aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat gtgtgaatat     1920

gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt ttgtcaaagc     1980

atcatctcaa cactgactgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcggcacccg cccgctcgcc cagccccagc acgcagccct gggagcatgt gaatgccatc     2100

caggaggccc ggcgtctcct gaacctgagt agagacactg ctgctgagat gaatgaaaca     2160

gtagaagtca tctcagaaat gtttgacctc caggagccga cctgcctaca gacccgcctg     2220

gagctgtaca agcagggcct gcggggcagc ctcaccaagc tcaagggccc cttgaccatg     2280

atggccagcc actacaagca gcactgccct ccaaccccgg aaacttcctg tgcaacccag     2340

attatcacct ttgaaagttt caaagagaac ctgaaggact ttctgcttgt catccccttt     2400

gactgctggg agccagtcca ggag                                            2424


<210>  83
<211>  2481
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL7GMCSF

<400>  83
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg attgtgatat tgaaggtaaa     1620

gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg     1680

aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt     1740

gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt     1800

aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca     1860

atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc     1920

caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac     1980

ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg     2040

ggcactaaag aacacggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gcacccgccc gctcgcccag ccccagcacg cagccctggg agcatgtgaa tgccatccag     2160

gaggcccggc gtctcctgaa cctgagtaga gacactgctg ctgagatgaa tgaaacagta     2220

gaagtcatct cagaaatgtt tgacctccag gagccgacct gcctacagac ccgcctggag     2280

ctgtacaagc agggcctgcg gggcagcctc accaagctca agggcccctt gaccatgatg     2340

gccagccact acaagcagca ctgccctcca accccggaaa cttcctgtgc aacccagatt     2400

atcacctttg aaagtttcaa agagaacctg aaggactttc tgcttgtcat cccctttgac     2460

tgctgggagc cagtccagga g                                               2481


<210>  84
<211>  2424
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL15GMCSF

<400>  84
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg gcattcatgt cttcattttg     1620

ggctgtttca gtgcagggct tcctaaaaca gaagccaact gggtgaatgt aataagtgat     1680

ttgaaaaaaa ttgaagatct tattcaatct atgcatattg atgctacttt atatacggaa     1740

agtgatgttc accccagttg caaagtaaca gcaatgaagt gctttctctt ggagttacaa     1800

gttatttcac ttgagtccgg agatgcaagt attcatgata cagtagaaaa tctgatcatc     1860

ctagcaaaca acagtttgtc ttctaatggg aatgtaacag aatctggatg caaagaatgt     1920

gaggaactgg aggaaaaaaa tattaaagaa tttttgcaga gttttgtaca tattgtccaa     1980

atgttcatca acacttctgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcggcacccg cccgctcgcc cagccccagc acgcagccct gggagcatgt gaatgccatc     2100

caggaggccc ggcgtctcct gaacctgagt agagacactg ctgctgagat gaatgaaaca     2160

gtagaagtca tctcagaaat gtttgacctc caggagccga cctgcctaca gacccgcctg     2220

gagctgtaca agcagggcct gcggggcagc ctcaccaagc tcaagggccc cttgaccatg     2280

atggccagcc actacaagca gcactgccct ccaaccccgg aaacttcctg tgcaacccag     2340

attatcacct ttgaaagttt caaagagaac ctgaaggact ttctgcttgt catccccttt     2400

gactgctggg agccagtcca ggag                                            2424


<210>  85
<211>  2424
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL21GMCSF

<400>  85
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aaggtcaaga tcgccacatg     1620

attagaatgc gtcaacttat agatattgtt gatcagctga aaaattatgt gaatgacttg     1680

gtccctgaat ttctgccagc tccagaagat gtagagacaa actgtgagtg gtcagctttt     1740

tcctgctttc agaaggccca actaaagtca gcaaatacag gaaacaatga aaggataatc     1800

aatgtatcaa ttaaaaagct gaagaggaaa ccaccttcca caaatgcagg gagaagacag     1860

aaacacagac taacatgccc ttcatgtgat tcttatgaga aaaaaccacc caaagaattc     1920

ctagaaagat tcaaatcact tctccaaaag atgattcatc agcatctgtc ctctagaaca     1980

cacggaagtg aagattccgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcggcacccg cccgctcgcc cagccccagc acgcagccct gggagcatgt gaatgccatc     2100

caggaggccc ggcgtctcct gaacctgagt agagacactg ctgctgagat gaatgaaaca     2160

gtagaagtca tctcagaaat gtttgacctc caggagccga cctgcctaca gacccgcctg     2220

gagctgtaca agcagggcct gcggggcagc ctcaccaagc tcaagggccc cttgaccatg     2280

atggccagcc actacaagca gcactgccct ccaaccccgg aaacttcctg tgcaacccag     2340

attatcacct ttgaaagttt caaagagaac ctgaaggact ttctgcttgt catccccttt     2400

gactgctggg agccagtcca ggag                                            2424


<210>  86
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2FLT3L

<400>  86
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg cacctacttc aagttctaca     1620

aagaaaacac agctacaact ggagcattta ctgctggatt tacagatgat tttgaatgga     1680

attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt ttacatgccc     1740

aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa acctctggag     1800

gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga cttaatcagc     1860

aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat gtgtgaatat     1920

gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt ttgtcaaagc     1980

atcatctcaa cactgactgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcgacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc     2100

cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag     2160

gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg     2220

ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata     2280

cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc     2340

aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc     2400

actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg     2460

ccacccccat ggagtccccg gcccctggag gccacagccc cgacagcccc gcagccccct     2520

ctgctcctcc tactgctgct gcccgtgggc ctcctgctgc tggccgctgc ctggtgcctg     2580

cactggcaga ggacgcggcg gaggacaccc cgccctgggg agcaggtgcc ccccgtcccc     2640

agtccccagg acctgctgct tgtggagcac                                      2670


<210>  87
<211>  2727
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL7FLT3L

<400>  87
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg attgtgatat tgaaggtaaa     1620

gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg     1680

aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt     1740

gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt     1800

aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca     1860

atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc     1920

caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac     1980

ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg     2040

ggcactaaag aacacggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

acccaggact gctccttcca acacagcccc atctcctccg acttcgctgt caaaatccgt     2160

gagctgtctg actacctgct tcaagattac ccagtcaccg tggcctccaa cctgcaggac     2220

gaggagctct gcgggggcct ctggcggctg gtcctggcac agcgctggat ggagcggctc     2280

aagactgtcg ctgggtccaa gatgcaaggc ttgctggagc gcgtgaacac ggagatacac     2340

tttgtcacca aatgtgcctt tcagcccccc cccagctgtc ttcgcttcgt ccagaccaac     2400

atctcccgcc tcctgcagga gacctccgag cagctggtgg cgctgaagcc ctggatcact     2460

cgccagaact tctcccggtg cctggagctg cagtgtcagc ccgactcctc aaccctgcca     2520

cccccatgga gtccccggcc cctggaggcc acagccccga cagccccgca gccccctctg     2580

ctcctcctac tgctgctgcc cgtgggcctc ctgctgctgg ccgctgcctg gtgcctgcac     2640

tggcagagga cgcggcggag gacaccccgc cctggggagc aggtgccccc cgtccccagt     2700

ccccaggacc tgctgcttgt ggagcac                                         2727


<210>  88
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL15FLT3L

<400>  88
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg gcattcatgt cttcattttg     1620

ggctgtttca gtgcagggct tcctaaaaca gaagccaact gggtgaatgt aataagtgat     1680

ttgaaaaaaa ttgaagatct tattcaatct atgcatattg atgctacttt atatacggaa     1740

agtgatgttc accccagttg caaagtaaca gcaatgaagt gctttctctt ggagttacaa     1800

gttatttcac ttgagtccgg agatgcaagt attcatgata cagtagaaaa tctgatcatc     1860

ctagcaaaca acagtttgtc ttctaatggg aatgtaacag aatctggatg caaagaatgt     1920

gaggaactgg aggaaaaaaa tattaaagaa tttttgcaga gttttgtaca tattgtccaa     1980

atgttcatca acacttctgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcgacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc     2100

cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag     2160

gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg     2220

ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata     2280

cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc     2340

aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc     2400

actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg     2460

ccacccccat ggagtccccg gcccctggag gccacagccc cgacagcccc gcagccccct     2520

ctgctcctcc tactgctgct gcccgtgggc ctcctgctgc tggccgctgc ctggtgcctg     2580

cactggcaga ggacgcggcg gaggacaccc cgccctgggg agcaggtgcc ccccgtcccc     2640

agtccccagg acctgctgct tgtggagcac                                      2670


<210>  89
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL21FLT3L

<400>  89
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aaggtcaaga tcgccacatg     1620

attagaatgc gtcaacttat agatattgtt gatcagctga aaaattatgt gaatgacttg     1680

gtccctgaat ttctgccagc tccagaagat gtagagacaa actgtgagtg gtcagctttt     1740

tcctgctttc agaaggccca actaaagtca gcaaatacag gaaacaatga aaggataatc     1800

aatgtatcaa ttaaaaagct gaagaggaaa ccaccttcca caaatgcagg gagaagacag     1860

aaacacagac taacatgccc ttcatgtgat tcttatgaga aaaaaccacc caaagaattc     1920

ctagaaagat tcaaatcact tctccaaaag atgattcatc agcatctgtc ctctagaaca     1980

cacggaagtg aagattccgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcgacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc     2100

cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag     2160

gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg     2220

ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata     2280

cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc     2340

aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc     2400

actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg     2460

ccacccccat ggagtccccg gcccctggag gccacagccc cgacagcccc gcagccccct     2520

ctgctcctcc tactgctgct gcccgtgggc ctcctgctgc tggccgctgc ctggtgcctg     2580

cactggcaga ggacgcggcg gaggacaccc cgccctgggg agcaggtgcc ccccgtcccc     2640

agtccccagg acctgctgct tgtggagcac                                      2670


<210>  90
<211>  3924
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19IL2GMCSF

<400>  90
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcag tttttcgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcatctat tagtggtagt tcgggtacca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaagacac ggccgtatat tactgtgcga aaccgtttcc gtattttgac     1920

tactggggcc agggaaccct ggtcaccgtc ggcggtagcg gaggggaaat tgtgttgacg     1980

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc     2040

agtcagagtg ttagcagcag ctttttagcc tggtaccagc agaaacctgg ccaggctccc     2100

aggctcctca tctattatgc atccagcagg gccactggca tcccagacag gttcagtggc     2160

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca     2220

gtgtattact gtcagcagac gggtcgtatt ccgccgacgt tcggccaagg gaccaaggtg     2280

gaaatcaaat cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtgaggtg     2340

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt     2400

gcagcctctg gattcacctt tagcagtttt tcgatgagct gggtccgcca ggctccaggg     2460

aaggggctgg agtgggtctc atctattagt ggtagttcgg gtaccacata ctacgcagac     2520

tccgtgaagg gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa     2580

atgaacagcc tgagagccga agacacggcc gtatattact gtgcgaaacc gtttccgtat     2640

tttgactact ggggccaggg aaccctggtc accgtcggcg gtagcggagg ggaaattgtg     2700

ttgacgcagt ctccaggcac cctgtctttg tctccagggg aaagagccac cctctcctgc     2760

agggccagtc agagtgttag cagcagcttt ttagcctggt accagcagaa acctggccag     2820

gctcccaggc tcctcatcta ttatgcatcc agcagggcca ctggcatccc agacaggttc     2880

agtggcagtg ggtctgggac agacttcact ctcaccatca gcagactgga gcctgaagat     2940

tttgcagtgt attactgtca gcagacgggt cgtattccgc cgacgttcgg ccaagggacc     3000

aaggtggaaa tcaaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     3060

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag     3120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc     3180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg     3240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg     3300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc     3360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc     3420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt     3480

caaagcatca tctcaacaag ccctcaatca agttcctctg gtagttcatc tagcggtagt     3540

tcttcatcgg gtgcacccac ccgctcaccc atcactgtca cccggccttg gaagcatgta     3600

gaggccatca aagaagccct gaacctcctg gatgacatgc ctgtcacgtt gaatgaagag     3660

gtagaagtcg tctctaacga gttctccttc aagaagctaa catgtgtgca gacccgcctg     3720

aagatattcg agcagggtct acggggcaat ttcaccaaac tcaagggcgc cttgaacatg     3780

acagccagct actaccagac atactgcccc ccaactccgg aaacggactg tgaaacacaa     3840

gttaccacct atgcggattt catagacagc cttaaaacct ttctgactga tatccccttt     3900

gaatgcaaaa aaccaggcca aaaa                                            3924


<210>  91
<211>  3948
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8IL2GMCSF

<400>  91
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcct gtttacgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcagctat tagtggtagt ggtggtagca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaggacac ggccgtatat tactgtgcga aaagtactca tttgtatctt     1920

tttgactact ggggccaggg aaccctggtc accgtctcca gtggcggtag cggaggggaa     1980

attgtgttga cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc     2040

tcctgcaggg ccagtcagag tgttagcatg ccgtttttag cctggtacca gcagaaacct     2100

ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagac     2160

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct     2220

gaagattttg cagtgtatta ctgtcagcag atgcgtggtc ggccgccgac gttcggccaa     2280

gggaccaagg tggaaatcaa atcttcaagt agcggttcaa gttcctctgg atcgtcaagc     2340

tctggtgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg     2400

agactctcct gtgcagcctc tggattcacc tttagcctgt ttacgatgag ctgggtccgc     2460

caggctccag ggaaggggct ggagtgggtc tcagctatta gtggtagtgg tggtagcaca     2520

tactacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg     2580

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa     2640

agtactcatt tgtatctttt tgactactgg ggccagggaa ccctggtcac cgtctccagt     2700

ggcggtagcg gaggggaaat tgtgttgacg cagtctccag gcaccctgtc tttgtctcca     2760

ggggaaagag ccaccctctc ctgcagggcc agtcagagtg ttagcatgcc gtttttagcc     2820

tggtaccagc agaaacctgg ccaggctccc aggctcctca tctatggtgc atccagcagg     2880

gccactggca tcccagacag gttcagtggc agtgggtctg ggacagactt cactctcacc     2940

atcagcagac tggagcctga agattttgca gtgtattact gtcagcagat gcgtggtcgg     3000

ccgccgacgt tcggccaagg gaccaaggtg gaaatcaaag gcggaggggg ttcaggtggg     3060

ggcgggagcg gaggtggcgg atcggcaccc acttcaagct ccacttcaag ctctacagcg     3120

gaagcacagc agcagcagca gcagcagcag cagcagcagc agcacctgga gcagctgttg     3180

atggacctac aggagctcct gagcaggatg gagaattaca ggaacctgaa actccccagg     3240

atgctcacct tcaaatttta cttgcccaag caggccacag aattgaaaga tcttcagtgc     3300

ctagaagatg aacttggacc tctgcggcat gttctggatt tgactcaaag caaaagcttt     3360

caattggaag atgctgagaa tttcatcagc aatatcagag taactgttgt aaaactaaag     3420

ggctctgaca acacatttga gtgccaattc gatgatgagt cagcaactgt ggtggacttt     3480

ctgaggagat ggatagcctt ctgtcaaagc atcatctcaa caagccctca atcaagttcc     3540

tctggtagtt catctagcgg tagttcttca tcgggtgcac ccacccgctc acccatcact     3600

gtcacccggc cttggaagca tgtagaggcc atcaaagaag ccctgaacct cctggatgac     3660

atgcctgtca cgttgaatga agaggtagaa gtcgtctcta acgagttctc cttcaagaag     3720

ctaacatgtg tgcagacccg cctgaagata ttcgagcagg gtctacgggg caatttcacc     3780

aaactcaagg gcgccttgaa catgacagcc agctactacc agacatactg ccccccaact     3840

ccggaaacgg actgtgaaac acaagttacc acctatgcgg atttcataga cagccttaaa     3900

acctttctga ctgatatccc ctttgaatgc aaaaaaccag gccaaaaa                  3948


<210>  92
<211>  3942
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76IL2GMCSF

<400>  92
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcca ggtgcagctg     1620

caggagagcg gccccggcct ggtgaagccc agcgagaccc tgagcctgac ctgcgccgtg     1680

agcggctaca gcatcagcag cggctactac tggggctgga tcaggcagcc ccccggcaag     1740

ggcctggagt ggatcggcag catctaccac agcggcagca cctactacaa ccccagcctg     1800

aagagcaggg tgaccatcag cgtggacacc agcaagaacc agttcagcct gaagctgagc     1860

agcgtgaccg ccgccgacac cgccgtgtac tactgcgcca ggggcaagtg gagcaagttc     1920

gactactggg gccagggcac cctggtgacc gtgagcagcg gcggtagcgg agggagcagc     1980

gagctgaccc aggaccccgc cgtgagcgtg gccctgggcc agaccgtgag gatcacctgc     2040

cagggcgaca gcctgaggag ctactacgcc agctggtacc agcagaagcc cggccaggcc     2100

cccgtgctgg tgatctacgg caagaacaac aggcccagcg gcatccccga caggttcagc     2160

ggcagcagca gcggcaacac cgccagcctg accatcaccg gcgcccaggc cgaggacgag     2220

gccgactact actgcaacag cagggacagc agcggcaacc acgtggtgtt cggcggcggc     2280

accaagctga ccgtgctgtc ttcaagtagc ggttcaagtt cctctggatc gtcaagctct     2340

ggtcaggtgc agctgcagga gagcggcccc ggcctggtga agcccagcga gaccctgagc     2400

ctgacctgcg ccgtgagcgg ctacagcatc agcagcggct actactgggg ctggatcagg     2460

cagccccccg gcaagggcct ggagtggatc ggcagcatct accacagcgg cagcacctac     2520

tacaacccca gcctgaagag cagggtgacc atcagcgtgg acaccagcaa gaaccagttc     2580

agcctgaagc tgagcagcgt gaccgccgcc gacaccgccg tgtactactg cgccaggggc     2640

aagtggagca agttcgacta ctggggccag ggcaccctgg tgaccgtgag cagcggcggt     2700

agcggaggga gcagcgagct gacccaggac cccgccgtga gcgtggccct gggccagacc     2760

gtgaggatca cctgccaggg cgacagcctg aggagctact acgccagctg gtaccagcag     2820

aagcccggcc aggcccccgt gctggtgatc tacggcaaga acaacaggcc cagcggcatc     2880

cccgacaggt tcagcggcag cagcagcggc aacaccgcca gcctgaccat caccggcgcc     2940

caggccgagg acgaggccga ctactactgc aacagcaggg acagcagcgg caaccacgtg     3000

gtgttcggcg gcggcaccaa gctgaccgtg ctgggcggag ggggttcagg tgggggcggg     3060

agcggaggtg gcggatcggc acccacttca agctccactt caagctctac agcggaagca     3120

cagcagcagc agcagcagca gcagcagcag cagcagcacc tggagcagct gttgatggac     3180

ctacaggagc tcctgagcag gatggagaat tacaggaacc tgaaactccc caggatgctc     3240

accttcaaat tttacttgcc caagcaggcc acagaattga aagatcttca gtgcctagaa     3300

gatgaacttg gacctctgcg gcatgttctg gatttgactc aaagcaaaag ctttcaattg     3360

gaagatgctg agaatttcat cagcaatatc agagtaactg ttgtaaaact aaagggctct     3420

gacaacacat ttgagtgcca attcgatgat gagtcagcaa ctgtggtgga ctttctgagg     3480

agatggatag ccttctgtca aagcatcatc tcaacaagcc ctcaatcaag ttcctctggt     3540

agttcatcta gcggtagttc ttcatcgggt gcacccaccc gctcacccat cactgtcacc     3600

cggccttgga agcatgtaga ggccatcaaa gaagccctga acctcctgga tgacatgcct     3660

gtcacgttga atgaagaggt agaagtcgtc tctaacgagt tctccttcaa gaagctaaca     3720

tgtgtgcaga cccgcctgaa gatattcgag cagggtctac ggggcaattt caccaaactc     3780

aagggcgcct tgaacatgac agccagctac taccagacat actgcccccc aactccggaa     3840

acggactgtg aaacacaagt taccacctat gcggatttca tagacagcct taaaaccttt     3900

ctgactgata tcccctttga atgcaaaaaa ccaggccaaa aa                        3942


<210>  93
<211>  3945
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76F8IL2GMCSF

<400>  93
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcca ggtgcagctg     1620

caggagagcg gccccggcct ggtgaagccc agcgagaccc tgagcctgac ctgcgccgtg     1680

agcggctaca gcatcagcag cggctactac tggggctgga tcaggcagcc ccccggcaag     1740

ggcctggagt ggatcggcag catctaccac agcggcagca cctactacaa ccccagcctg     1800

aagagcaggg tgaccatcag cgtggacacc agcaagaacc agttcagcct gaagctgagc     1860

agcgtgaccg ccgccgacac cgccgtgtac tactgcgcca ggggcaagtg gagcaagttc     1920

gactactggg gccagggcac cctggtgacc gtgagcagcg gcggtagcgg aggggaaatt     1980

gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc caccctctcc     2040

tgcagggcca gtcagagtgt tagcatgccg tttttagcct ggtaccagca gaaacctggc     2100

caggctccca ggctcctcat ctatggtgca tccagcaggg ccactggcat cccagacagg     2160

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa     2220

gattttgcag tgtattactg tcagcagatg cgtggtcggc cgccgacgtt cggccaaggg     2280

accaaggtgg aaatcaaatc ttcaagtagc ggttcaagtt cctctggatc gtcaagctct     2340

ggtgaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga     2400

ctctcctgtg cagcctctgg attcaccttt agcctgttta cgatgagctg ggtccgccag     2460

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac     2520

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg     2580

tatctgcaaa tgaacagcct gagagccgag gacacggccg tatattactg tgcgaaaagt     2640

actcatttgt atctttttga ctactggggc cagggaaccc tggtcaccgt ctccagtggc     2700

ggtagcggag ggagcagcga gctgacccag gaccccgccg tgagcgtggc cctgggccag     2760

accgtgagga tcacctgcca gggcgacagc ctgaggagct actacgccag ctggtaccag     2820

cagaagcccg gccaggcccc cgtgctggtg atctacggca agaacaacag gcccagcggc     2880

atccccgaca ggttcagcgg cagcagcagc ggcaacaccg ccagcctgac catcaccggc     2940

gcccaggccg aggacgaggc cgactactac tgcaacagca gggacagcag cggcaaccac     3000

gtggtgttcg gcggcggcac caagctgacc gtgctgggcg gagggggttc aggtgggggc     3060

gggagcggag gtggcggatc ggcacccact tcaagctcca cttcaagctc tacagcggaa     3120

gcacagcagc agcagcagca gcagcagcag cagcagcagc acctggagca gctgttgatg     3180

gacctacagg agctcctgag caggatggag aattacagga acctgaaact ccccaggatg     3240

ctcaccttca aattttactt gcccaagcag gccacagaat tgaaagatct tcagtgccta     3300

gaagatgaac ttggacctct gcggcatgtt ctggatttga ctcaaagcaa aagctttcaa     3360

ttggaagatg ctgagaattt catcagcaat atcagagtaa ctgttgtaaa actaaagggc     3420

tctgacaaca catttgagtg ccaattcgat gatgagtcag caactgtggt ggactttctg     3480

aggagatgga tagccttctg tcaaagcatc atctcaacaa gccctcaatc aagttcctct     3540

ggtagttcat ctagcggtag ttcttcatcg ggtgcaccca cccgctcacc catcactgtc     3600

acccggcctt ggaagcatgt agaggccatc aaagaagccc tgaacctcct ggatgacatg     3660

cctgtcacgt tgaatgaaga ggtagaagtc gtctctaacg agttctcctt caagaagcta     3720

acatgtgtgc agacccgcct gaagatattc gagcagggtc tacggggcaa tttcaccaaa     3780

ctcaagggcg ccttgaacat gacagccagc tactaccaga catactgccc cccaactccg     3840

gaaacggact gtgaaacaca agttaccacc tatgcggatt tcatagacag ccttaaaacc     3900

tttctgactg atatcccctt tgaatgcaaa aaaccaggcc aaaaa                     3945


<210>  94
<211>  3933
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaNHS76L19IL2GMCSF

<400>  94
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcca ggtgcagctg     1620

caggagagcg gccccggcct ggtgaagccc agcgagaccc tgagcctgac ctgcgccgtg     1680

agcggctaca gcatcagcag cggctactac tggggctgga tcaggcagcc ccccggcaag     1740

ggcctggagt ggatcggcag catctaccac agcggcagca cctactacaa ccccagcctg     1800

aagagcaggg tgaccatcag cgtggacacc agcaagaacc agttcagcct gaagctgagc     1860

agcgtgaccg ccgccgacac cgccgtgtac tactgcgcca ggggcaagtg gagcaagttc     1920

gactactggg gccagggcac cctggtgacc gtgagcagcg gcggtagcgg aggggaaatt     1980

gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc caccctctcc     2040

tgcagggcca gtcagagtgt tagcagcagc tttttagcct ggtaccagca gaaacctggc     2100

caggctccca ggctcctcat ctattatgca tccagcaggg ccactggcat cccagacagg     2160

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa     2220

gattttgcag tgtattactg tcagcagacg ggtcgtattc cgccgacgtt cggccaaggg     2280

accaaggtgg aaatcaaatc ttcaagtagc ggttcaagtt cctctggatc gtcaagctct     2340

ggtgaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga     2400

ctctcctgtg cagcctctgg attcaccttt agcagttttt cgatgagctg ggtccgccag     2460

gctccaggga aggggctgga gtgggtctca tctattagtg gtagttcggg taccacatac     2520

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg     2580

tatctgcaaa tgaacagcct gagagccgaa gacacggccg tatattactg tgcgaaaccg     2640

tttccgtatt ttgactactg gggccaggga accctggtca ccgtcggcgg tagcggaggg     2700

agcagcgagc tgacccagga ccccgccgtg agcgtggccc tgggccagac cgtgaggatc     2760

acctgccagg gcgacagcct gaggagctac tacgccagct ggtaccagca gaagcccggc     2820

caggcccccg tgctggtgat ctacggcaag aacaacaggc ccagcggcat ccccgacagg     2880

ttcagcggca gcagcagcgg caacaccgcc agcctgacca tcaccggcgc ccaggccgag     2940

gacgaggccg actactactg caacagcagg gacagcagcg gcaaccacgt ggtgttcggc     3000

ggcggcacca agctgaccgt gctgggcgga gggggttcag gtgggggcgg gagcggaggt     3060

ggcggatcgg cacccacttc aagctccact tcaagctcta cagcggaagc acagcagcag     3120

cagcagcagc agcagcagca gcagcagcac ctggagcagc tgttgatgga cctacaggag     3180

ctcctgagca ggatggagaa ttacaggaac ctgaaactcc ccaggatgct caccttcaaa     3240

ttttacttgc ccaagcaggc cacagaattg aaagatcttc agtgcctaga agatgaactt     3300

ggacctctgc ggcatgttct ggatttgact caaagcaaaa gctttcaatt ggaagatgct     3360

gagaatttca tcagcaatat cagagtaact gttgtaaaac taaagggctc tgacaacaca     3420

tttgagtgcc aattcgatga tgagtcagca actgtggtgg actttctgag gagatggata     3480

gccttctgtc aaagcatcat ctcaacaagc cctcaatcaa gttcctctgg tagttcatct     3540

agcggtagtt cttcatcggg tgcacccacc cgctcaccca tcactgtcac ccggccttgg     3600

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     3660

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     3720

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     3780

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     3840

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     3900

atcccctttg aatgcaaaaa accaggccaa aaa                                  3933


<210>  95
<211>  3945
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8NHS76IL2GMCSF

<400>  95
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcct gtttacgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcagctat tagtggtagt ggtggtagca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaggacac ggccgtatat tactgtgcga aaagtactca tttgtatctt     1920

tttgactact ggggccaggg aaccctggtc accgtctcca gtggcggtag cggagggagc     1980

agcgagctga cccaggaccc cgccgtgagc gtggccctgg gccagaccgt gaggatcacc     2040

tgccagggcg acagcctgag gagctactac gccagctggt accagcagaa gcccggccag     2100

gcccccgtgc tggtgatcta cggcaagaac aacaggccca gcggcatccc cgacaggttc     2160

agcggcagca gcagcggcaa caccgccagc ctgaccatca ccggcgccca ggccgaggac     2220

gaggccgact actactgcaa cagcagggac agcagcggca accacgtggt gttcggcggc     2280

ggcaccaagc tgaccgtgct gtcttcaagt agcggttcaa gttcctctgg atcgtcaagc     2340

tctggtcagg tgcagctgca ggagagcggc cccggcctgg tgaagcccag cgagaccctg     2400

agcctgacct gcgccgtgag cggctacagc atcagcagcg gctactactg gggctggatc     2460

aggcagcccc ccggcaaggg cctggagtgg atcggcagca tctaccacag cggcagcacc     2520

tactacaacc ccagcctgaa gagcagggtg accatcagcg tggacaccag caagaaccag     2580

ttcagcctga agctgagcag cgtgaccgcc gccgacaccg ccgtgtacta ctgcgccagg     2640

ggcaagtgga gcaagttcga ctactggggc cagggcaccc tggtgaccgt gagcagcggc     2700

ggtagcggag gggaaattgt gttgacgcag tctccaggca ccctgtcttt gtctccaggg     2760

gaaagagcca ccctctcctg cagggccagt cagagtgtta gcatgccgtt tttagcctgg     2820

taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc     2880

actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc     2940

agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagatgcg tggtcggccg     3000

ccgacgttcg gccaagggac caaggtggaa atcaaaggcg gagggggttc aggtgggggc     3060

gggagcggag gtggcggatc ggcacccact tcaagctcca cttcaagctc tacagcggaa     3120

gcacagcagc agcagcagca gcagcagcag cagcagcagc acctggagca gctgttgatg     3180

gacctacagg agctcctgag caggatggag aattacagga acctgaaact ccccaggatg     3240

ctcaccttca aattttactt gcccaagcag gccacagaat tgaaagatct tcagtgccta     3300

gaagatgaac ttggacctct gcggcatgtt ctggatttga ctcaaagcaa aagctttcaa     3360

ttggaagatg ctgagaattt catcagcaat atcagagtaa ctgttgtaaa actaaagggc     3420

tctgacaaca catttgagtg ccaattcgat gatgagtcag caactgtggt ggactttctg     3480

aggagatgga tagccttctg tcaaagcatc atctcaacaa gccctcaatc aagttcctct     3540

ggtagttcat ctagcggtag ttcttcatcg ggtgcaccca cccgctcacc catcactgtc     3600

acccggcctt ggaagcatgt agaggccatc aaagaagccc tgaacctcct ggatgacatg     3660

cctgtcacgt tgaatgaaga ggtagaagtc gtctctaacg agttctcctt caagaagcta     3720

acatgtgtgc agacccgcct gaagatattc gagcagggtc tacggggcaa tttcaccaaa     3780

ctcaagggcg ccttgaacat gacagccagc tactaccaga catactgccc cccaactccg     3840

gaaacggact gtgaaacaca agttaccacc tatgcggatt tcatagacag ccttaaaacc     3900

tttctgactg atatcccctt tgaatgcaaa aaaccaggcc aaaaa                     3945


<210>  96
<211>  3936
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaF8L19IL2GMCSF

<400>  96
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcct gtttacgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcagctat tagtggtagt ggtggtagca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaggacac ggccgtatat tactgtgcga aaagtactca tttgtatctt     1920

tttgactact ggggccaggg aaccctggtc accgtctcca gtggcggtag cggaggggaa     1980

attgtgttga cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc     2040

tcctgcaggg ccagtcagag tgttagcagc agctttttag cctggtacca gcagaaacct     2100

ggccaggctc ccaggctcct catctattat gcatccagca gggccactgg catcccagac     2160

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct     2220

gaagattttg cagtgtatta ctgtcagcag acgggtcgta ttccgccgac gttcggccaa     2280

gggaccaagg tggaaatcaa atcttcaagt agcggttcaa gttcctctgg atcgtcaagc     2340

tctggtgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg     2400

agactctcct gtgcagcctc tggattcacc tttagcagtt tttcgatgag ctgggtccgc     2460

caggctccag ggaaggggct ggagtgggtc tcatctatta gtggtagttc gggtaccaca     2520

tactacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg     2580

ctgtatctgc aaatgaacag cctgagagcc gaagacacgg ccgtatatta ctgtgcgaaa     2640

ccgtttccgt attttgacta ctggggccag ggaaccctgg tcaccgtcgg cggtagcgga     2700

ggggaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     2760

accctctcct gcagggccag tcagagtgtt agcatgccgt ttttagcctg gtaccagcag     2820

aaacctggcc aggctcccag gctcctcatc tatggtgcat ccagcagggc cactggcatc     2880

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     2940

gagcctgaag attttgcagt gtattactgt cagcagatgc gtggtcggcc gccgacgttc     3000

ggccaaggga ccaaggtgga aatcaaaggc ggagggggtt caggtggggg cgggagcgga     3060

ggtggcggat cggcacccac ttcaagctcc acttcaagct ctacagcgga agcacagcag     3120

cagcagcagc agcagcagca gcagcagcag cacctggagc agctgttgat ggacctacag     3180

gagctcctga gcaggatgga gaattacagg aacctgaaac tccccaggat gctcaccttc     3240

aaattttact tgcccaagca ggccacagaa ttgaaagatc ttcagtgcct agaagatgaa     3300

cttggacctc tgcggcatgt tctggatttg actcaaagca aaagctttca attggaagat     3360

gctgagaatt tcatcagcaa tatcagagta actgttgtaa aactaaaggg ctctgacaac     3420

acatttgagt gccaattcga tgatgagtca gcaactgtgg tggactttct gaggagatgg     3480

atagccttct gtcaaagcat catctcaaca agccctcaat caagttcctc tggtagttca     3540

tctagcggta gttcttcatc gggtgcaccc acccgctcac ccatcactgt cacccggcct     3600

tggaagcatg tagaggccat caaagaagcc ctgaacctcc tggatgacat gcctgtcacg     3660

ttgaatgaag aggtagaagt cgtctctaac gagttctcct tcaagaagct aacatgtgtg     3720

cagacccgcc tgaagatatt cgagcagggt ctacggggca atttcaccaa actcaagggc     3780

gccttgaaca tgacagccag ctactaccag acatactgcc ccccaactcc ggaaacggac     3840

tgtgaaacac aagttaccac ctatgcggat ttcatagaca gccttaaaac ctttctgact     3900

gatatcccct ttgaatgcaa aaaaccaggc caaaaa                               3936


<210>  97
<211>  3933
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19NHS76IL2GMCSF

<400>  97
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcag tttttcgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcatctat tagtggtagt tcgggtacca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaagacac ggccgtatat tactgtgcga aaccgtttcc gtattttgac     1920

tactggggcc agggaaccct ggtcaccgtc ggcggtagcg gagggagcag cgagctgacc     1980

caggaccccg ccgtgagcgt ggccctgggc cagaccgtga ggatcacctg ccagggcgac     2040

agcctgagga gctactacgc cagctggtac cagcagaagc ccggccaggc ccccgtgctg     2100

gtgatctacg gcaagaacaa caggcccagc ggcatccccg acaggttcag cggcagcagc     2160

agcggcaaca ccgccagcct gaccatcacc ggcgcccagg ccgaggacga ggccgactac     2220

tactgcaaca gcagggacag cagcggcaac cacgtggtgt tcggcggcgg caccaagctg     2280

accgtgctgt cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtcaggtg     2340

cagctgcagg agagcggccc cggcctggtg aagcccagcg agaccctgag cctgacctgc     2400

gccgtgagcg gctacagcat cagcagcggc tactactggg gctggatcag gcagcccccc     2460

ggcaagggcc tggagtggat cggcagcatc taccacagcg gcagcaccta ctacaacccc     2520

agcctgaaga gcagggtgac catcagcgtg gacaccagca agaaccagtt cagcctgaag     2580

ctgagcagcg tgaccgccgc cgacaccgcc gtgtactact gcgccagggg caagtggagc     2640

aagttcgact actggggcca gggcaccctg gtgaccgtga gcagcggcgg tagcggaggg     2700

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     2760

ctctcctgca gggccagtca gagtgttagc agcagctttt tagcctggta ccagcagaaa     2820

cctggccagg ctcccaggct cctcatctat tatgcatcca gcagggccac tggcatccca     2880

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     2940

cctgaagatt ttgcagtgta ttactgtcag cagacgggtc gtattccgcc gacgttcggc     3000

caagggacca aggtggaaat caaaggcgga gggggttcag gtgggggcgg gagcggaggt     3060

ggcggatcgg cacccacttc aagctccact tcaagctcta cagcggaagc acagcagcag     3120

cagcagcagc agcagcagca gcagcagcac ctggagcagc tgttgatgga cctacaggag     3180

ctcctgagca ggatggagaa ttacaggaac ctgaaactcc ccaggatgct caccttcaaa     3240

ttttacttgc ccaagcaggc cacagaattg aaagatcttc agtgcctaga agatgaactt     3300

ggacctctgc ggcatgttct ggatttgact caaagcaaaa gctttcaatt ggaagatgct     3360

gagaatttca tcagcaatat cagagtaact gttgtaaaac taaagggctc tgacaacaca     3420

tttgagtgcc aattcgatga tgagtcagca actgtggtgg actttctgag gagatggata     3480

gccttctgtc aaagcatcat ctcaacaagc cctcaatcaa gttcctctgg tagttcatct     3540

agcggtagtt cttcatcggg tgcacccacc cgctcaccca tcactgtcac ccggccttgg     3600

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     3660

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     3720

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     3780

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     3840

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     3900

atcccctttg aatgcaaaaa accaggccaa aaa                                  3933


<210>  98
<211>  3936
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aDiaL19F8IL2GMCSF

<400>  98
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcga ggtgcagctg     1620

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1680

tctggattca cctttagcag tttttcgatg agctgggtcc gccaggctcc agggaagggg     1740

ctggagtggg tctcatctat tagtggtagt tcgggtacca catactacgc agactccgtg     1800

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctgtatct gcaaatgaac     1860

agcctgagag ccgaagacac ggccgtatat tactgtgcga aaccgtttcc gtattttgac     1920

tactggggcc agggaaccct ggtcaccgtc ggcggtagcg gaggggaaat tgtgttgacg     1980

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc     2040

agtcagagtg ttagcatgcc gtttttagcc tggtaccagc agaaacctgg ccaggctccc     2100

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc     2160

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca     2220

gtgtattact gtcagcagat gcgtggtcgg ccgccgacgt tcggccaagg gaccaaggtg     2280

gaaatcaaat cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtgaggtg     2340

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt     2400

gcagcctctg gattcacctt tagcctgttt acgatgagct gggtccgcca ggctccaggg     2460

aaggggctgg agtgggtctc agctattagt ggtagtggtg gtagcacata ctacgcagac     2520

tccgtgaagg gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa     2580

atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgaaaag tactcatttg     2640

tatctttttg actactgggg ccagggaacc ctggtcaccg tctccagtgg cggtagcgga     2700

ggggaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     2760

accctctcct gcagggccag tcagagtgtt agcagcagct ttttagcctg gtaccagcag     2820

aaacctggcc aggctcccag gctcctcatc tattatgcat ccagcagggc cactggcatc     2880

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     2940

gagcctgaag attttgcagt gtattactgt cagcagacgg gtcgtattcc gccgacgttc     3000

ggccaaggga ccaaggtgga aatcaaaggc ggagggggtt caggtggggg cgggagcgga     3060

ggtggcggat cggcacccac ttcaagctcc acttcaagct ctacagcgga agcacagcag     3120

cagcagcagc agcagcagca gcagcagcag cacctggagc agctgttgat ggacctacag     3180

gagctcctga gcaggatgga gaattacagg aacctgaaac tccccaggat gctcaccttc     3240

aaattttact tgcccaagca ggccacagaa ttgaaagatc ttcagtgcct agaagatgaa     3300

cttggacctc tgcggcatgt tctggatttg actcaaagca aaagctttca attggaagat     3360

gctgagaatt tcatcagcaa tatcagagta actgttgtaa aactaaaggg ctctgacaac     3420

acatttgagt gccaattcga tgatgagtca gcaactgtgg tggactttct gaggagatgg     3480

atagccttct gtcaaagcat catctcaaca agccctcaat caagttcctc tggtagttca     3540

tctagcggta gttcttcatc gggtgcaccc acccgctcac ccatcactgt cacccggcct     3600

tggaagcatg tagaggccat caaagaagcc ctgaacctcc tggatgacat gcctgtcacg     3660

ttgaatgaag aggtagaagt cgtctctaac gagttctcct tcaagaagct aacatgtgtg     3720

cagacccgcc tgaagatatt cgagcagggt ctacggggca atttcaccaa actcaagggc     3780

gccttgaaca tgacagccag ctactaccag acatactgcc ccccaactcc ggaaacggac     3840

tgtgaaacac aagttaccac ctatgcggat ttcatagaca gccttaaaac ctttctgact     3900

gatatcccct ttgaatgcaa aaaaccaggc caaaaa                               3936


<210>  99
<211>  3945
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaNHS76F8GMCSF

<400>  99
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

caggtgcagc tgcaggagag cggccccggc ctggtgaagc ccagcgagac cctgagcctg     2160

acctgcgccg tgagcggcta cagcatcagc agcggctact actggggctg gatcaggcag     2220

ccccccggca agggcctgga gtggatcggc agcatctacc acagcggcag cacctactac     2280

aaccccagcc tgaagagcag ggtgaccatc agcgtggaca ccagcaagaa ccagttcagc     2340

ctgaagctga gcagcgtgac cgccgccgac accgccgtgt actactgcgc caggggcaag     2400

tggagcaagt tcgactactg gggccagggc accctggtga ccgtgagcag cggcggtagc     2460

ggaggggaaa ttgtgttgac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga     2520

gccaccctct cctgcagggc cagtcagagt gttagcatgc cgtttttagc ctggtaccag     2580

cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag ggccactggc     2640

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga     2700

ctggagcctg aagattttgc agtgtattac tgtcagcaga tgcgtggtcg gccgccgacg     2760

ttcggccaag ggaccaaggt ggaaatcaaa tcttcaagta gcggttcaag ttcctctgga     2820

tcgtcaagct ctggtgaggt gcagctgttg gagtctgggg gaggcttggt acagcctggg     2880

gggtccctga gactctcctg tgcagcctct ggattcacct ttagcctgtt tacgatgagc     2940

tgggtccgcc aggctccagg gaaggggctg gagtgggtct cagctattag tggtagtggt     3000

ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc     3060

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac     3120

tgtgcgaaaa gtactcattt gtatcttttt gactactggg gccagggaac cctggtcacc     3180

gtctccagtg gcggtagcgg agggagcagc gagctgaccc aggaccccgc cgtgagcgtg     3240

gccctgggcc agaccgtgag gatcacctgc cagggcgaca gcctgaggag ctactacgcc     3300

agctggtacc agcagaagcc cggccaggcc cccgtgctgg tgatctacgg caagaacaac     3360

aggcccagcg gcatccccga caggttcagc ggcagcagca gcggcaacac cgccagcctg     3420

accatcaccg gcgcccaggc cgaggacgag gccgactact actgcaacag cagggacagc     3480

agcggcaacc acgtggtgtt cggcggcggc accaagctga ccgtgctgtc aagttcctct     3540

ggtagttcat ctagcggtag ttcttcatcg ggtgcaccca cccgctcacc catcactgtc     3600

acccggcctt ggaagcatgt agaggccatc aaagaagccc tgaacctcct ggatgacatg     3660

cctgtcacgt tgaatgaaga ggtagaagtc gtctctaacg agttctcctt caagaagcta     3720

acatgtgtgc agacccgcct gaagatattc gagcagggtc tacggggcaa tttcaccaaa     3780

ctcaagggcg ccttgaacat gacagccagc tactaccaga catactgccc cccaactccg     3840

gaaacggact gtgaaacaca agttaccacc tatgcggatt tcatagacag ccttaaaacc     3900

tttctgactg atatcccctt tgaatgcaaa aaaccaggcc aaaaa                     3945


<210>  100
<211>  3948
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaF8GMCSF

<400>  100
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     2160

tcctgtgcag cctctggatt cacctttagc ctgtttacga tgagctgggt ccgccaggct     2220

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     2280

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     2340

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagtact     2400

catttgtatc tttttgacta ctggggccag ggaaccctgg tcaccgtctc cagtggcggt     2460

agcggagggg aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa     2520

agagccaccc tctcctgcag ggccagtcag agtgttagca tgccgttttt agcctggtac     2580

cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccag cagggccact     2640

ggcatcccag acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     2700

agactggagc ctgaagattt tgcagtgtat tactgtcagc agatgcgtgg tcggccgccg     2760

acgttcggcc aagggaccaa ggtggaaatc aaatcttcaa gtagcggttc aagttcctct     2820

ggatcgtcaa gctctggtga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct     2880

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcct gtttacgatg     2940

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt     3000

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat     3060

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtatat     3120

tactgtgcga aaagtactca tttgtatctt tttgactact ggggccaggg aaccctggtc     3180

accgtctcca gtggcggtag cggaggggaa attgtgttga cgcagtctcc aggcaccctg     3240

tctttgtctc caggggaaag agccaccctc tcctgcaggg ccagtcagag tgttagcatg     3300

ccgtttttag cctggtacca gcagaaacct ggccaggctc ccaggctcct catctatggt     3360

gcatccagca gggccactgg catcccagac aggttcagtg gcagtgggtc tgggacagac     3420

ttcactctca ccatcagcag actggagcct gaagattttg cagtgtatta ctgtcagcag     3480

atgcgtggtc ggccgccgac gttcggccaa gggaccaagg tggaaatcaa atcaagttcc     3540

tctggtagtt catctagcgg tagttcttca tcgggtgcac ccacccgctc acccatcact     3600

gtcacccggc cttggaagca tgtagaggcc atcaaagaag ccctgaacct cctggatgac     3660

atgcctgtca cgttgaatga agaggtagaa gtcgtctcta acgagttctc cttcaagaag     3720

ctaacatgtg tgcagacccg cctgaagata ttcgagcagg gtctacgggg caatttcacc     3780

aaactcaagg gcgccttgaa catgacagcc agctactacc agacatactg ccccccaact     3840

ccggaaacgg actgtgaaac acaagttacc acctatgcgg atttcataga cagccttaaa     3900

acctttctga ctgatatccc ctttgaatgc aaaaaaccag gccaaaaa                  3948


<210>  101
<211>  3945
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSFDiaNHS76F8

<400>  101
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa     2160

gaagccctga acctcctgga tgacatgcct gtcacgttga atgaagaggt agaagtcgtc     2220

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag     2280

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac     2340

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat     2400

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa     2460

ccaggccaaa aatcaagttc ctctggtagt tcatctagcg gtagttcttc atcgggtcag     2520

gtgcagctgc aggagagcgg ccccggcctg gtgaagccca gcgagaccct gagcctgacc     2580

tgcgccgtga gcggctacag catcagcagc ggctactact ggggctggat caggcagccc     2640

cccggcaagg gcctggagtg gatcggcagc atctaccaca gcggcagcac ctactacaac     2700

cccagcctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg     2760

aagctgagca gcgtgaccgc cgccgacacc gccgtgtact actgcgccag gggcaagtgg     2820

agcaagttcg actactgggg ccagggcacc ctggtgaccg tgagcagcgg cggtagcgga     2880

ggggaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     2940

accctctcct gcagggccag tcagagtgtt agcatgccgt ttttagcctg gtaccagcag     3000

aaacctggcc aggctcccag gctcctcatc tatggtgcat ccagcagggc cactggcatc     3060

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     3120

gagcctgaag attttgcagt gtattactgt cagcagatgc gtggtcggcc gccgacgttc     3180

ggccaaggga ccaaggtgga aatcaaatct tcaagtagcg gttcaagttc ctctggatcg     3240

tcaagctctg gtgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg     3300

tccctgagac tctcctgtgc agcctctgga ttcaccttta gcctgtttac gatgagctgg     3360

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt     3420

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     3480

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggccgt atattactgt     3540

gcgaaaagta ctcatttgta tctttttgac tactggggcc agggaaccct ggtcaccgtc     3600

tccagtggcg gtagcggagg gagcagcgag ctgacccagg accccgccgt gagcgtggcc     3660

ctgggccaga ccgtgaggat cacctgccag ggcgacagcc tgaggagcta ctacgccagc     3720

tggtaccagc agaagcccgg ccaggccccc gtgctggtga tctacggcaa gaacaacagg     3780

cccagcggca tccccgacag gttcagcggc agcagcagcg gcaacaccgc cagcctgacc     3840

atcaccggcg cccaggccga ggacgaggcc gactactact gcaacagcag ggacagcagc     3900

ggcaaccacg tggtgttcgg cggcggcacc aagctgaccg tgctg                     3945


<210>  102
<211>  3948
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2GMCSFDiaF8

<400>  102
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ggtgggggcg ggagcggagg tggcggatcg     2100

gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa     2160

gaagccctga acctcctgga tgacatgcct gtcacgttga atgaagaggt agaagtcgtc     2220

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag     2280

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac     2340

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat     2400

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa     2460

ccaggccaaa aatcaagttc ctctggtagt tcatctagcg gtagttcttc atcgggtgag     2520

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc     2580

tgtgcagcct ctggattcac ctttagcctg tttacgatga gctgggtccg ccaggctcca     2640

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca     2700

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg     2760

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aagtactcat     2820

ttgtatcttt ttgactactg gggccaggga accctggtca ccgtctccag tggcggtagc     2880

ggaggggaaa ttgtgttgac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga     2940

gccaccctct cctgcagggc cagtcagagt gttagcatgc cgtttttagc ctggtaccag     3000

cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag ggccactggc     3060

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga     3120

ctggagcctg aagattttgc agtgtattac tgtcagcaga tgcgtggtcg gccgccgacg     3180

ttcggccaag ggaccaaggt ggaaatcaaa tcttcaagta gcggttcaag ttcctctgga     3240

tcgtcaagct ctggtgaggt gcagctgttg gagtctgggg gaggcttggt acagcctggg     3300

gggtccctga gactctcctg tgcagcctct ggattcacct ttagcctgtt tacgatgagc     3360

tgggtccgcc aggctccagg gaaggggctg gagtgggtct cagctattag tggtagtggt     3420

ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc     3480

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac     3540

tgtgcgaaaa gtactcattt gtatcttttt gactactggg gccagggaac cctggtcacc     3600

gtctccagtg gcggtagcgg aggggaaatt gtgttgacgc agtctccagg caccctgtct     3660

ttgtctccag gggaaagagc caccctctcc tgcagggcca gtcagagtgt tagcatgccg     3720

tttttagcct ggtaccagca gaaacctggc caggctccca ggctcctcat ctatggtgca     3780

tccagcaggg ccactggcat cccagacagg ttcagtggca gtgggtctgg gacagacttc     3840

actctcacca tcagcagact ggagcctgaa gattttgcag tgtattactg tcagcagatg     3900

cgtggtcggc cgccgacgtt cggccaaggg accaaggtgg aaatcaaa                  3948


<210>  103
<211>  3876
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaL19IL2GMCSF

<400>  103
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg aggtgcagct gttggagtct     1620

gggggaggct tggtacagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc     1680

acctttagca gtttttcgat gagctgggtc cgccaggctc cagggaaggg gctggagtgg     1740

gtctcatcta ttagtggtag ttcgggtacc acatactacg cagactccgt gaagggccgg     1800

ttcaccatct ccagagacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgaga     1860

gccgaagaca cggccgtata ttactgtgcg aaaccgtttc cgtattttga ctactggggc     1920

cagggaaccc tggtcaccgt cggcggtagc ggaggggaaa ttgtgttgac gcagtctcca     1980

ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt     2040

gttagcagca gctttttagc ctggtaccag cagaaacctg gccaggctcc caggctcctc     2100

atctattatg catccagcag ggccactggc atcccagaca ggttcagtgg cagtgggtct     2160

gggacagact tcactctcac catcagcaga ctggagcctg aagattttgc agtgtattac     2220

tgtcagcaga cgggtcgtat tccgccgacg ttcggccaag ggaccaaggt ggaaatcaaa     2280

tcttcaagta gcggttcaag ttcctctgga tcgtcaagct ctggtgaggt gcagctgttg     2340

gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg tgcagcctct     2400

ggattcacct ttagcagttt ttcgatgagc tgggtccgcc aggctccagg gaaggggctg     2460

gagtgggtct catctattag tggtagttcg ggtaccacat actacgcaga ctccgtgaag     2520

ggccggttca ccatctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc     2580

ctgagagccg aagacacggc cgtatattac tgtgcgaaac cgtttccgta ttttgactac     2640

tggggccagg gaaccctggt caccgtcggc ggtagcggag gggaaattgt gttgacgcag     2700

tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt     2760

cagagtgtta gcagcagctt tttagcctgg taccagcaga aacctggcca ggctcccagg     2820

ctcctcatct attatgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt     2880

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg     2940

tattactgtc agcagacggg tcgtattccg ccgacgttcg gccaagggac caaggtggaa     3000

atcaaaggcg gagggggttc aggtgggggc gggagcggag gtggcggatc ggcacctact     3060

tcaagttcta caaagaaaac acagctacaa ctggagcatt tactgctgga tttacagatg     3120

attttgaatg gaattaataa ttacaagaat cccaaactca ccaggatgct cacatttaag     3180

ttttacatgc ccaagaaggc cacagaactg aaacatcttc agtgtctaga agaagaactc     3240

aaacctctgg aggaagtgct aaatttagct caaagcaaaa actttcactt aagacccagg     3300

gacttaatca gcaatatcaa cgtaatagtt ctggaactaa agggatctga aacaacattc     3360

atgtgtgaat atgctgatga gacagcaacc attgtagaat ttctgaacag atggattacc     3420

ttttgtcaaa gcatcatctc aacactgact tcaagttcct ctggtagttc atctagcggt     3480

agttcttcat cgggtgcacc cgcccgctcg cccagcccca gcacgcagcc ctgggagcat     3540

gtgaatgcca tccaggaggc ccggcgtctc ctgaacctga gtagagacac tgctgctgag     3600

atgaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggagcc gacctgccta     3660

cagacccgcc tggagctgta caagcagggc ctgcggggca gcctcaccaa gctcaagggc     3720

cccttgacca tgatggccag ccactacaag cagcactgcc ctccaacccc ggaaacttcc     3780

tgtgcaaccc agattatcac ctttgaaagt ttcaaagaga acctgaagga ctttctgctt     3840

gtcatcccct ttgactgctg ggagccagtc caggag                               3876


<210>  104
<211>  3894
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76IL2GMCSF

<400>  104
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aggtgcagct gcaggagagc     1620

ggccccggcc tggtgaagcc cagcgagacc ctgagcctga cctgcgccgt gagcggctac     1680

agcatcagca gcggctacta ctggggctgg atcaggcagc cccccggcaa gggcctggag     1740

tggatcggca gcatctacca cagcggcagc acctactaca accccagcct gaagagcagg     1800

gtgaccatca gcgtggacac cagcaagaac cagttcagcc tgaagctgag cagcgtgacc     1860

gccgccgaca ccgccgtgta ctactgcgcc aggggcaagt ggagcaagtt cgactactgg     1920

ggccagggca ccctggtgac cgtgagcagc ggcggtagcg gagggagcag cgagctgacc     1980

caggaccccg ccgtgagcgt ggccctgggc cagaccgtga ggatcacctg ccagggcgac     2040

agcctgagga gctactacgc cagctggtac cagcagaagc ccggccaggc ccccgtgctg     2100

gtgatctacg gcaagaacaa caggcccagc ggcatccccg acaggttcag cggcagcagc     2160

agcggcaaca ccgccagcct gaccatcacc ggcgcccagg ccgaggacga ggccgactac     2220

tactgcaaca gcagggacag cagcggcaac cacgtggtgt tcggcggcgg caccaagctg     2280

accgtgctgt cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtcaggtg     2340

cagctgcagg agagcggccc cggcctggtg aagcccagcg agaccctgag cctgacctgc     2400

gccgtgagcg gctacagcat cagcagcggc tactactggg gctggatcag gcagcccccc     2460

ggcaagggcc tggagtggat cggcagcatc taccacagcg gcagcaccta ctacaacccc     2520

agcctgaaga gcagggtgac catcagcgtg gacaccagca agaaccagtt cagcctgaag     2580

ctgagcagcg tgaccgccgc cgacaccgcc gtgtactact gcgccagggg caagtggagc     2640

aagttcgact actggggcca gggcaccctg gtgaccgtga gcagcggcgg tagcggaggg     2700

agcagcgagc tgacccagga ccccgccgtg agcgtggccc tgggccagac cgtgaggatc     2760

acctgccagg gcgacagcct gaggagctac tacgccagct ggtaccagca gaagcccggc     2820

caggcccccg tgctggtgat ctacggcaag aacaacaggc ccagcggcat ccccgacagg     2880

ttcagcggca gcagcagcgg caacaccgcc agcctgacca tcaccggcgc ccaggccgag     2940

gacgaggccg actactactg caacagcagg gacagcagcg gcaaccacgt ggtgttcggc     3000

ggcggcacca agctgaccgt gctgggcgga gggggttcag gtgggggcgg gagcggaggt     3060

ggcggatcgg cacctacttc aagttctaca aagaaaacac agctacaact ggagcattta     3120

ctgctggatt tacagatgat tttgaatgga attaataatt acaagaatcc caaactcacc     3180

aggatgctca catttaagtt ttacatgccc aagaaggcca cagaactgaa acatcttcag     3240

tgtctagaag aagaactcaa acctctggag gaagtgctaa atttagctca aagcaaaaac     3300

tttcacttaa gacccaggga cttaatcagc aatatcaacg taatagttct ggaactaaag     3360

ggatctgaaa caacattcat gtgtgaatat gctgatgaga cagcaaccat tgtagaattt     3420

ctgaacagat ggattacctt ttgtcaaagc atcatctcaa cactgacttc aagttcctct     3480

ggtagttcat ctagcggtag ttcttcatcg ggtgcacccg cccgctcgcc cagccccagc     3540

acgcagccct gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt     3600

agagacactg ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc     3660

caggagccga cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc     3720

ctcaccaagc tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct     3780

ccaaccccgg aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac     3840

ctgaaggact ttctgcttgt catccccttt gactgctggg agccagtcca ggag           3894


<210>  105
<211>  3897
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76F8IL2GMCSF

<400>  105
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aggtgcagct gcaggagagc     1620

ggccccggcc tggtgaagcc cagcgagacc ctgagcctga cctgcgccgt gagcggctac     1680

agcatcagca gcggctacta ctggggctgg atcaggcagc cccccggcaa gggcctggag     1740

tggatcggca gcatctacca cagcggcagc acctactaca accccagcct gaagagcagg     1800

gtgaccatca gcgtggacac cagcaagaac cagttcagcc tgaagctgag cagcgtgacc     1860

gccgccgaca ccgccgtgta ctactgcgcc aggggcaagt ggagcaagtt cgactactgg     1920

ggccagggca ccctggtgac cgtgagcagc ggcggtagcg gaggggaaat tgtgttgacg     1980

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc     2040

agtcagagtg ttagcatgcc gtttttagcc tggtaccagc agaaacctgg ccaggctccc     2100

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc     2160

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca     2220

gtgtattact gtcagcagat gcgtggtcgg ccgccgacgt tcggccaagg gaccaaggtg     2280

gaaatcaaat cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtgaggtg     2340

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt     2400

gcagcctctg gattcacctt tagcctgttt acgatgagct gggtccgcca ggctccaggg     2460

aaggggctgg agtgggtctc agctattagt ggtagtggtg gtagcacata ctacgcagac     2520

tccgtgaagg gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa     2580

atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgaaaag tactcatttg     2640

tatctttttg actactgggg ccagggaacc ctggtcaccg tctccagtgg cggtagcgga     2700

gggagcagcg agctgaccca ggaccccgcc gtgagcgtgg ccctgggcca gaccgtgagg     2760

atcacctgcc agggcgacag cctgaggagc tactacgcca gctggtacca gcagaagccc     2820

ggccaggccc ccgtgctggt gatctacggc aagaacaaca ggcccagcgg catccccgac     2880

aggttcagcg gcagcagcag cggcaacacc gccagcctga ccatcaccgg cgcccaggcc     2940

gaggacgagg ccgactacta ctgcaacagc agggacagca gcggcaacca cgtggtgttc     3000

ggcggcggca ccaagctgac cgtgctgggc ggagggggtt caggtggggg cgggagcgga     3060

ggtggcggat cggcacctac ttcaagttct acaaagaaaa cacagctaca actggagcat     3120

ttactgctgg atttacagat gattttgaat ggaattaata attacaagaa tcccaaactc     3180

accaggatgc tcacatttaa gttttacatg cccaagaagg ccacagaact gaaacatctt     3240

cagtgtctag aagaagaact caaacctctg gaggaagtgc taaatttagc tcaaagcaaa     3300

aactttcact taagacccag ggacttaatc agcaatatca acgtaatagt tctggaacta     3360

aagggatctg aaacaacatt catgtgtgaa tatgctgatg agacagcaac cattgtagaa     3420

tttctgaaca gatggattac cttttgtcaa agcatcatct caacactgac ttcaagttcc     3480

tctggtagtt catctagcgg tagttcttca tcgggtgcac ccgcccgctc gcccagcccc     3540

agcacgcagc cctgggagca tgtgaatgcc atccaggagg cccggcgtct cctgaacctg     3600

agtagagaca ctgctgctga gatgaatgaa acagtagaag tcatctcaga aatgtttgac     3660

ctccaggagc cgacctgcct acagacccgc ctggagctgt acaagcaggg cctgcggggc     3720

agcctcacca agctcaaggg ccccttgacc atgatggcca gccactacaa gcagcactgc     3780

cctccaaccc cggaaacttc ctgtgcaacc cagattatca cctttgaaag tttcaaagag     3840

aacctgaagg actttctgct tgtcatcccc tttgactgct gggagccagt ccaggag        3897


<210>  106
<211>  3897
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaNHS76F8GMCSF

<400>  106
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg cacctacttc aagttctaca     1620

aagaaaacac agctacaact ggagcattta ctgctggatt tacagatgat tttgaatgga     1680

attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt ttacatgccc     1740

aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa acctctggag     1800

gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga cttaatcagc     1860

aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat gtgtgaatat     1920

gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt ttgtcaaagc     1980

atcatctcaa cactgactgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcgcaggtgc agctgcagga gagcggcccc ggcctggtga agcccagcga gaccctgagc     2100

ctgacctgcg ccgtgagcgg ctacagcatc agcagcggct actactgggg ctggatcagg     2160

cagccccccg gcaagggcct ggagtggatc ggcagcatct accacagcgg cagcacctac     2220

tacaacccca gcctgaagag cagggtgacc atcagcgtgg acaccagcaa gaaccagttc     2280

agcctgaagc tgagcagcgt gaccgccgcc gacaccgccg tgtactactg cgccaggggc     2340

aagtggagca agttcgacta ctggggccag ggcaccctgg tgaccgtgag cagcggcggt     2400

agcggagggg aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa     2460

agagccaccc tctcctgcag ggccagtcag agtgttagca tgccgttttt agcctggtac     2520

cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccag cagggccact     2580

ggcatcccag acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     2640

agactggagc ctgaagattt tgcagtgtat tactgtcagc agatgcgtgg tcggccgccg     2700

acgttcggcc aagggaccaa ggtggaaatc aaatcttcaa gtagcggttc aagttcctct     2760

ggatcgtcaa gctctggtga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct     2820

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcct gtttacgatg     2880

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt     2940

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat     3000

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtatat     3060

tactgtgcga aaagtactca tttgtatctt tttgactact ggggccaggg aaccctggtc     3120

accgtctcca gtggcggtag cggagggagc agcgagctga cccaggaccc cgccgtgagc     3180

gtggccctgg gccagaccgt gaggatcacc tgccagggcg acagcctgag gagctactac     3240

gccagctggt accagcagaa gcccggccag gcccccgtgc tggtgatcta cggcaagaac     3300

aacaggccca gcggcatccc cgacaggttc agcggcagca gcagcggcaa caccgccagc     3360

ctgaccatca ccggcgccca ggccgaggac gaggccgact actactgcaa cagcagggac     3420

agcagcggca accacgtggt gttcggcggc ggcaccaagc tgaccgtgct gtcaagttcc     3480

tctggtagtt catctagcgg tagttcttca tcgggtgcac ccgcccgctc gcccagcccc     3540

agcacgcagc cctgggagca tgtgaatgcc atccaggagg cccggcgtct cctgaacctg     3600

agtagagaca ctgctgctga gatgaatgaa acagtagaag tcatctcaga aatgtttgac     3660

ctccaggagc cgacctgcct acagacccgc ctggagctgt acaagcaggg cctgcggggc     3720

agcctcacca agctcaaggg ccccttgacc atgatggcca gccactacaa gcagcactgc     3780

cctccaaccc cggaaacttc ctgtgcaacc cagattatca cctttgaaag tttcaaagag     3840

aacctgaagg actttctgct tgtcatcccc tttgactgct gggagccagt ccaggag        3897


<210>  107
<211>  3900
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaF8GMCSF

<400>  107
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg cacctacttc aagttctaca     1620

aagaaaacac agctacaact ggagcattta ctgctggatt tacagatgat tttgaatgga     1680

attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt ttacatgccc     1740

aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa acctctggag     1800

gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga cttaatcagc     1860

aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat gtgtgaatat     1920

gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt ttgtcaaagc     1980

atcatctcaa cactgactgg cggagggggt tcaggtgggg gcgggagcgg aggtggcgga     2040

tcggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga     2100

ctctcctgtg cagcctctgg attcaccttt agcctgttta cgatgagctg ggtccgccag     2160

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac     2220

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg     2280

tatctgcaaa tgaacagcct gagagccgag gacacggccg tatattactg tgcgaaaagt     2340

actcatttgt atctttttga ctactggggc cagggaaccc tggtcaccgt ctccagtggc     2400

ggtagcggag gggaaattgt gttgacgcag tctccaggca ccctgtcttt gtctccaggg     2460

gaaagagcca ccctctcctg cagggccagt cagagtgtta gcatgccgtt tttagcctgg     2520

taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc     2580

actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc     2640

agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagatgcg tggtcggccg     2700

ccgacgttcg gccaagggac caaggtggaa atcaaatctt caagtagcgg ttcaagttcc     2760

tctggatcgt caagctctgg tgaggtgcag ctgttggagt ctgggggagg cttggtacag     2820

cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttag cctgtttacg     2880

atgagctggg tccgccaggc tccagggaag gggctggagt gggtctcagc tattagtggt     2940

agtggtggta gcacatacta cgcagactcc gtgaagggcc ggttcaccat ctccagagac     3000

aattccaaga acacgctgta tctgcaaatg aacagcctga gagccgagga cacggccgta     3060

tattactgtg cgaaaagtac tcatttgtat ctttttgact actggggcca gggaaccctg     3120

gtcaccgtct ccagtggcgg tagcggaggg gaaattgtgt tgacgcagtc tccaggcacc     3180

ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttagc     3240

atgccgtttt tagcctggta ccagcagaaa cctggccagg ctcccaggct cctcatctat     3300

ggtgcatcca gcagggccac tggcatccca gacaggttca gtggcagtgg gtctgggaca     3360

gacttcactc tcaccatcag cagactggag cctgaagatt ttgcagtgta ttactgtcag     3420

cagatgcgtg gtcggccgcc gacgttcggc caagggacca aggtggaaat caaatcaagt     3480

tcctctggta gttcatctag cggtagttct tcatcgggtg cacccgcccg ctcgcccagc     3540

cccagcacgc agccctggga gcatgtgaat gccatccagg aggcccggcg tctcctgaac     3600

ctgagtagag acactgctgc tgagatgaat gaaacagtag aagtcatctc agaaatgttt     3660

gacctccagg agccgacctg cctacagacc cgcctggagc tgtacaagca gggcctgcgg     3720

ggcagcctca ccaagctcaa gggccccttg accatgatgg ccagccacta caagcagcac     3780

tgccctccaa ccccggaaac ttcctgtgca acccagatta tcacctttga aagtttcaaa     3840

gagaacctga aggactttct gcttgtcatc ccctttgact gctgggagcc agtccaggag     3900


<210>  108
<211>  3876
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaL19GMCSFIL2

<400>  108
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg aggtgcagct gttggagtct     1620

gggggaggct tggtacagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc     1680

acctttagca gtttttcgat gagctgggtc cgccaggctc cagggaaggg gctggagtgg     1740

gtctcatcta ttagtggtag ttcgggtacc acatactacg cagactccgt gaagggccgg     1800

ttcaccatct ccagagacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgaga     1860

gccgaagaca cggccgtata ttactgtgcg aaaccgtttc cgtattttga ctactggggc     1920

cagggaaccc tggtcaccgt cggcggtagc ggaggggaaa ttgtgttgac gcagtctcca     1980

ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt     2040

gttagcagca gctttttagc ctggtaccag cagaaacctg gccaggctcc caggctcctc     2100

atctattatg catccagcag ggccactggc atcccagaca ggttcagtgg cagtgggtct     2160

gggacagact tcactctcac catcagcaga ctggagcctg aagattttgc agtgtattac     2220

tgtcagcaga cgggtcgtat tccgccgacg ttcggccaag ggaccaaggt ggaaatcaaa     2280

tcttcaagta gcggttcaag ttcctctgga tcgtcaagct ctggtgaggt gcagctgttg     2340

gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg tgcagcctct     2400

ggattcacct ttagcagttt ttcgatgagc tgggtccgcc aggctccagg gaaggggctg     2460

gagtgggtct catctattag tggtagttcg ggtaccacat actacgcaga ctccgtgaag     2520

ggccggttca ccatctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc     2580

ctgagagccg aagacacggc cgtatattac tgtgcgaaac cgtttccgta ttttgactac     2640

tggggccagg gaaccctggt caccgtcggc ggtagcggag gggaaattgt gttgacgcag     2700

tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt     2760

cagagtgtta gcagcagctt tttagcctgg taccagcaga aacctggcca ggctcccagg     2820

ctcctcatct attatgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt     2880

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg     2940

tattactgtc agcagacggg tcgtattccg ccgacgttcg gccaagggac caaggtggaa     3000

atcaaaggcg gagggggttc aggtgggggc gggagcggag gtggcggatc ggcacccgcc     3060

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg     3120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc     3180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag     3240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac     3300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt     3360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag     3420

ccagtccagg agtcaagttc ctctggtagt tcatctagcg gtagttcttc atcgggtgca     3480

cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta     3540

cagatgattt tgaatggaat taataattac aagaatccca aactcaccag gatgctcaca     3600

tttaagtttt acatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa     3660

gaactcaaac ctctggagga agtgctaaat ttagctcaaa gcaaaaactt tcacttaaga     3720

cccagggact taatcagcaa tatcaacgta atagttctgg aactaaaggg atctgaaaca     3780

acattcatgt gtgaatatgc tgatgagaca gcaaccattg tagaatttct gaacagatgg     3840

attacctttt gtcaaagcat catctcaaca ctgact                               3876


<210>  109
<211>  3894
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76GMCSFIL2

<400>  109
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aggtgcagct gcaggagagc     1620

ggccccggcc tggtgaagcc cagcgagacc ctgagcctga cctgcgccgt gagcggctac     1680

agcatcagca gcggctacta ctggggctgg atcaggcagc cccccggcaa gggcctggag     1740

tggatcggca gcatctacca cagcggcagc acctactaca accccagcct gaagagcagg     1800

gtgaccatca gcgtggacac cagcaagaac cagttcagcc tgaagctgag cagcgtgacc     1860

gccgccgaca ccgccgtgta ctactgcgcc aggggcaagt ggagcaagtt cgactactgg     1920

ggccagggca ccctggtgac cgtgagcagc ggcggtagcg gagggagcag cgagctgacc     1980

caggaccccg ccgtgagcgt ggccctgggc cagaccgtga ggatcacctg ccagggcgac     2040

agcctgagga gctactacgc cagctggtac cagcagaagc ccggccaggc ccccgtgctg     2100

gtgatctacg gcaagaacaa caggcccagc ggcatccccg acaggttcag cggcagcagc     2160

agcggcaaca ccgccagcct gaccatcacc ggcgcccagg ccgaggacga ggccgactac     2220

tactgcaaca gcagggacag cagcggcaac cacgtggtgt tcggcggcgg caccaagctg     2280

accgtgctgt cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtcaggtg     2340

cagctgcagg agagcggccc cggcctggtg aagcccagcg agaccctgag cctgacctgc     2400

gccgtgagcg gctacagcat cagcagcggc tactactggg gctggatcag gcagcccccc     2460

ggcaagggcc tggagtggat cggcagcatc taccacagcg gcagcaccta ctacaacccc     2520

agcctgaaga gcagggtgac catcagcgtg gacaccagca agaaccagtt cagcctgaag     2580

ctgagcagcg tgaccgccgc cgacaccgcc gtgtactact gcgccagggg caagtggagc     2640

aagttcgact actggggcca gggcaccctg gtgaccgtga gcagcggcgg tagcggaggg     2700

agcagcgagc tgacccagga ccccgccgtg agcgtggccc tgggccagac cgtgaggatc     2760

acctgccagg gcgacagcct gaggagctac tacgccagct ggtaccagca gaagcccggc     2820

caggcccccg tgctggtgat ctacggcaag aacaacaggc ccagcggcat ccccgacagg     2880

ttcagcggca gcagcagcgg caacaccgcc agcctgacca tcaccggcgc ccaggccgag     2940

gacgaggccg actactactg caacagcagg gacagcagcg gcaaccacgt ggtgttcggc     3000

ggcggcacca agctgaccgt gctgggcgga gggggttcag gtgggggcgg gagcggaggt     3060

ggcggatcgg cacccgcccg ctcgcccagc cccagcacgc agccctggga gcatgtgaat     3120

gccatccagg aggcccggcg tctcctgaac ctgagtagag acactgctgc tgagatgaat     3180

gaaacagtag aagtcatctc agaaatgttt gacctccagg agccgacctg cctacagacc     3240

cgcctggagc tgtacaagca gggcctgcgg ggcagcctca ccaagctcaa gggccccttg     3300

accatgatgg ccagccacta caagcagcac tgccctccaa ccccggaaac ttcctgtgca     3360

acccagatta tcacctttga aagtttcaaa gagaacctga aggactttct gcttgtcatc     3420

ccctttgact gctgggagcc agtccaggag tcaagttcct ctggtagttc atctagcggt     3480

agttcttcat cgggtgcacc tacttcaagt tctacaaaga aaacacagct acaactggag     3540

catttactgc tggatttaca gatgattttg aatggaatta ataattacaa gaatcccaaa     3600

ctcaccagga tgctcacatt taagttttac atgcccaaga aggccacaga actgaaacat     3660

cttcagtgtc tagaagaaga actcaaacct ctggaggaag tgctaaattt agctcaaagc     3720

aaaaactttc acttaagacc cagggactta atcagcaata tcaacgtaat agttctggaa     3780

ctaaagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc aaccattgta     3840

gaatttctga acagatggat taccttttgt caaagcatca tctcaacact gact           3894


<210>  110
<211>  3897
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aDiaNHS76F8GMCSFIL2

<400>  110
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcc aggtgcagct gcaggagagc     1620

ggccccggcc tggtgaagcc cagcgagacc ctgagcctga cctgcgccgt gagcggctac     1680

agcatcagca gcggctacta ctggggctgg atcaggcagc cccccggcaa gggcctggag     1740

tggatcggca gcatctacca cagcggcagc acctactaca accccagcct gaagagcagg     1800

gtgaccatca gcgtggacac cagcaagaac cagttcagcc tgaagctgag cagcgtgacc     1860

gccgccgaca ccgccgtgta ctactgcgcc aggggcaagt ggagcaagtt cgactactgg     1920

ggccagggca ccctggtgac cgtgagcagc ggcggtagcg gaggggaaat tgtgttgacg     1980

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc     2040

agtcagagtg ttagcatgcc gtttttagcc tggtaccagc agaaacctgg ccaggctccc     2100

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc     2160

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca     2220

gtgtattact gtcagcagat gcgtggtcgg ccgccgacgt tcggccaagg gaccaaggtg     2280

gaaatcaaat cttcaagtag cggttcaagt tcctctggat cgtcaagctc tggtgaggtg     2340

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt     2400

gcagcctctg gattcacctt tagcctgttt acgatgagct gggtccgcca ggctccaggg     2460

aaggggctgg agtgggtctc agctattagt ggtagtggtg gtagcacata ctacgcagac     2520

tccgtgaagg gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa     2580

atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgaaaag tactcatttg     2640

tatctttttg actactgggg ccagggaacc ctggtcaccg tctccagtgg cggtagcgga     2700

gggagcagcg agctgaccca ggaccccgcc gtgagcgtgg ccctgggcca gaccgtgagg     2760

atcacctgcc agggcgacag cctgaggagc tactacgcca gctggtacca gcagaagccc     2820

ggccaggccc ccgtgctggt gatctacggc aagaacaaca ggcccagcgg catccccgac     2880

aggttcagcg gcagcagcag cggcaacacc gccagcctga ccatcaccgg cgcccaggcc     2940

gaggacgagg ccgactacta ctgcaacagc agggacagca gcggcaacca cgtggtgttc     3000

ggcggcggca ccaagctgac cgtgctgggc ggagggggtt caggtggggg cgggagcgga     3060

ggtggcggat cggcacccgc ccgctcgccc agccccagca cgcagccctg ggagcatgtg     3120

aatgccatcc aggaggcccg gcgtctcctg aacctgagta gagacactgc tgctgagatg     3180

aatgaaacag tagaagtcat ctcagaaatg tttgacctcc aggagccgac ctgcctacag     3240

acccgcctgg agctgtacaa gcagggcctg cggggcagcc tcaccaagct caagggcccc     3300

ttgaccatga tggccagcca ctacaagcag cactgccctc caaccccgga aacttcctgt     3360

gcaacccaga ttatcacctt tgaaagtttc aaagagaacc tgaaggactt tctgcttgtc     3420

atcccctttg actgctggga gccagtccag gagtcaagtt cctctggtag ttcatctagc     3480

ggtagttctt catcgggtgc acctacttca agttctacaa agaaaacaca gctacaactg     3540

gagcatttac tgctggattt acagatgatt ttgaatggaa ttaataatta caagaatccc     3600

aaactcacca ggatgctcac atttaagttt tacatgccca agaaggccac agaactgaaa     3660

catcttcagt gtctagaaga agaactcaaa cctctggagg aagtgctaaa tttagctcaa     3720

agcaaaaact ttcacttaag acccagggac ttaatcagca atatcaacgt aatagttctg     3780

gaactaaagg gatctgaaac aacattcatg tgtgaatatg ctgatgagac agcaaccatt     3840

gtagaatttc tgaacagatg gattaccttt tgtcaaagca tcatctcaac actgact        3897


<210>  111
<211>  3948
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12bIL12aIL2DiaNHS76F8GMCSF-Thr

<400>  111
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctcg      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatccg gaggcggtgg aagtggcggt      960

ggaggctctg gaggtggcgg aagcagggtc attccagtct ctggacctgc caggtgtctt     1020

agccagtccc gaaacctgct gaagaccaca gatgacatgg tgaagacggc cagagaaaaa     1080

ctgaaacatt attcctgcac tgctgaagac atcgatcatg aagacatcac acgggaccaa     1140

accagcacat tgaagacctg tttaccactg gaactacaca agaacgagag ttgcctggct     1200

actagagaga cttcttccac aacaagaggg agctgcctgc ccccacagaa gacgtctttg     1260

atgatgaccc tgtgccttgg tagcatctat gaggacttga agatgtacca gacagagttc     1320

caggccatca acgcagcact tcagaatcac aaccatcagc agatcattct agacaagggc     1380

atgctggtgg ccatcgatga gctgatgcag tctctgaatc ataatggcga gactctgcgc     1440

cagaaacctc ctgtgggaga agcagaccct tacagagtga aaatgaagct ctgcatcctg     1500

cttcacgcct tcagcacccg cgtcgtgacc atcaacaggg tgatgggcta tctgagctcc     1560

gccggtggag gaggttctgg aggcggtgga agtggtggcg gaggtagcgc acccacttca     1620

agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag     1680

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat     1740

tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc     1800

acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg     1860

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc     1920

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat     1980

gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc     2040

tcaacaagcc ctcaaggcgg agggggttca ctcgtcccaa gaggaagtgg aggtggcgga     2100

tcgcaggtgc agctgcagga gagcggcccc ggcctggtga agcccagcga gaccctgagc     2160

ctgacctgcg ccgtgagcgg ctacagcatc agcagcggct actactgggg ctggatcagg     2220

cagccccccg gcaagggcct ggagtggatc ggcagcatct accacagcgg cagcacctac     2280

tacaacccca gcctgaagag cagggtgacc atcagcgtgg acaccagcaa gaaccagttc     2340

agcctgaagc tgagcagcgt gaccgccgcc gacaccgccg tgtactactg cgccaggggc     2400

aagtggagca agttcgacta ctggggccag ggcaccctgg tgaccgtgag cagcggcggt     2460

agcggagggg aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa     2520

agagccaccc tctcctgcag ggccagtcag agtgttagca tgccgttttt agcctggtac     2580

cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccag cagggccact     2640

ggcatcccag acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     2700

agactggagc ctgaagattt tgcagtgtat tactgtcagc agatgcgtgg tcggccgccg     2760

acgttcggcc aagggaccaa ggtggaaatc aaatcttcaa gtagcggttc aagttcctct     2820

ggatcgtcaa gctctggtga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct     2880

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcct gtttacgatg     2940

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt     3000

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat     3060

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtatat     3120

tactgtgcga aaagtactca tttgtatctt tttgactact ggggccaggg aaccctggtc     3180

accgtctcca gtggcggtag cggagggagc agcgagctga cccaggaccc cgccgtgagc     3240

gtggccctgg gccagaccgt gaggatcacc tgccagggcg acagcctgag gagctactac     3300

gccagctggt accagcagaa gcccggccag gcccccgtgc tggtgatcta cggcaagaac     3360

aacaggccca gcggcatccc cgacaggttc agcggcagca gcagcggcaa caccgccagc     3420

ctgaccatca ccggcgccca ggccgaggac gaggccgact actactgcaa cagcagggac     3480

agcagcggca accacgtggt gttcggcggc ggcaccaagc tgaccgtgct gtcttcaagt     3540

agcggtctcg tcccaagagg aagttcaagc tctggtgcac ccacccgctc acccatcact     3600

gtcacccggc cttggaagca tgtagaggcc atcaaagaag ccctgaacct cctggatgac     3660

atgcctgtca cgttgaatga agaggtagaa gtcgtctcta acgagttctc cttcaagaag     3720

ctaacatgtg tgcagacccg cctgaagata ttcgagcagg gtctacgggg caatttcacc     3780

aaactcaagg gcgccttgaa catgacagcc agctactacc agacatactg ccccccaact     3840

ccggaaacgg actgtgaaac acaagttacc acctatgcgg atttcataga cagccttaaa     3900

acctttctga ctgatatccc ctttgaatgc aaaaaaccag gccaaaaa                  3948


<210>  112
<211>  3900
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12bIL12aIL2DiaNHS76F8GMCSF-Thr

<400>  112
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga      960

agcagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc     1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt     1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca     1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag     1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc     1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg     1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca     1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc     1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct     1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtgga     1560

ggaggttctg gaggcggtgg aagtggtggc ggaggtagcg cacctacttc aagttctaca     1620

aagaaaacac agctacaact ggagcattta ctgctggatt tacagatgat tttgaatgga     1680

attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt ttacatgccc     1740

aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa acctctggag     1800

gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga cttaatcagc     1860

aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat gtgtgaatat     1920

gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt ttgtcaaagc     1980

atcatctcaa cactgactgg cggagggggt tcactcgtcc caagaggaag tggaggtggc     2040

ggatcgcagg tgcagctgca ggagagcggc cccggcctgg tgaagcccag cgagaccctg     2100

agcctgacct gcgccgtgag cggctacagc atcagcagcg gctactactg gggctggatc     2160

aggcagcccc ccggcaaggg cctggagtgg atcggcagca tctaccacag cggcagcacc     2220

tactacaacc ccagcctgaa gagcagggtg accatcagcg tggacaccag caagaaccag     2280

ttcagcctga agctgagcag cgtgaccgcc gccgacaccg ccgtgtacta ctgcgccagg     2340

ggcaagtgga gcaagttcga ctactggggc cagggcaccc tggtgaccgt gagcagcggc     2400

ggtagcggag gggaaattgt gttgacgcag tctccaggca ccctgtcttt gtctccaggg     2460

gaaagagcca ccctctcctg cagggccagt cagagtgtta gcatgccgtt tttagcctgg     2520

taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc     2580

actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc     2640

agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagatgcg tggtcggccg     2700

ccgacgttcg gccaagggac caaggtggaa atcaaatctt caagtagcgg ttcaagttcc     2760

tctggatcgt caagctctgg tgaggtgcag ctgttggagt ctgggggagg cttggtacag     2820

cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttag cctgtttacg     2880

atgagctggg tccgccaggc tccagggaag gggctggagt gggtctcagc tattagtggt     2940

agtggtggta gcacatacta cgcagactcc gtgaagggcc ggttcaccat ctccagagac     3000

aattccaaga acacgctgta tctgcaaatg aacagcctga gagccgagga cacggccgta     3060

tattactgtg cgaaaagtac tcatttgtat ctttttgact actggggcca gggaaccctg     3120

gtcaccgtct ccagtggcgg tagcggaggg agcagcgagc tgacccagga ccccgccgtg     3180

agcgtggccc tgggccagac cgtgaggatc acctgccagg gcgacagcct gaggagctac     3240

tacgccagct ggtaccagca gaagcccggc caggcccccg tgctggtgat ctacggcaag     3300

aacaacaggc ccagcggcat ccccgacagg ttcagcggca gcagcagcgg caacaccgcc     3360

agcctgacca tcaccggcgc ccaggccgag gacgaggccg actactactg caacagcagg     3420

gacagcagcg gcaaccacgt ggtgttcggc ggcggcacca agctgaccgt gctgtcttca     3480

agtagcggtc tcgtcccaag aggaagttca agctctggtg cacccgcccg ctcgcccagc     3540

cccagcacgc agccctggga gcatgtgaat gccatccagg aggcccggcg tctcctgaac     3600

ctgagtagag acactgctgc tgagatgaat gaaacagtag aagtcatctc agaaatgttt     3660

gacctccagg agccgacctg cctacagacc cgcctggagc tgtacaagca gggcctgcgg     3720

ggcagcctca ccaagctcaa gggccccttg accatgatgg ccagccacta caagcagcac     3780

tgccctccaa ccccggaaac ttcctgtgca acccagatta tcacctttga aagtttcaaa     3840

gagaacctga aggactttct gcttgtcatc ccctttgact gctgggagcc agtccaggag     3900


<210>  113
<211>  2616
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ˫mIL12aIL2-IL12bGMCSF

<400>  113
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gcacccactt caagctccac ttcaagctct      720

acagcggaag cacagcagca gcagcagcag cagcagcagc agcagcagca cctggagcag      780

ctgttgatgg acctacagga gctcctgagc aggatggaga attacaggaa cctgaaactc      840

cccaggatgc tcaccttcaa attttacttg cccaagcagg ccacagaatt gaaagatctt      900

cagtgcctag aagatgaact tggacctctg cggcatgttc tggatttgac tcaaagcaaa      960

agctttcaat tggaagatgc tgagaatttc atcagcaata tcagagtaac tgttgtaaaa     1020

ctaaagggct ctgacaacac atttgagtgc caattcgatg atgagtcagc aactgtggtg     1080

gactttctga ggagatggat agccttctgt caaagcatca tctcaacaag ccctcaagag     1140

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1200

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1260

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1320

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1380

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1440

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1500

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1560

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1620

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1680

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1740

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1800

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1860

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1920

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1980

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     2040

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2100

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2160

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2220

ggctctggag gtggcggaag cgcacccacc cgctcaccca tcactgtcac ccggccttgg     2280

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     2340

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     2400

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     2460

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     2520

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     2580

atcccctttg aatgcaaaaa accaggccaa aaatga                               2616


<210>  114
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1--IL2DiaNHS76F8֮linkerϸ֮linkerҲ
       ϸӺ֮ӣ

<400>  114

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  115
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  2--滻IL2DiaNHS76F8֮linker

<400>  115

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  116
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3--DiaNHS76F8GMCSF֮linkerϸ֮linkerҲ
       ϸӺ֮ӣ

<400>  116

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4--滻DiaNHS76F8GMCSF֮linker

<400>  117

Ser Ser Ser Ser Gly Leu Val Pro Arg Gly Ser Ser Ser Ser Gly 
1               5                   10                  15  


<210>  118
<211>  452
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ˫ںϵ׵ĵڶIL12bGMCSF

<400>  118

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile Thr 
                325                 330                 335     


Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn 
            340                 345                 350         


Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val 
        355                 360                 365             


Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu 
    370                 375                 380                 


Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly 
385                 390                 395                 400 


Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr 
                405                 410                 415     


Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile 
            420                 425                 430         


Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys 
        435                 440                 445             


Pro Gly Gln Lys 
    450         


