                         SEQUENCE LISTING



<110>  USC

       UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

 

<120>  Intracellular delivery of anti-KRAS antibodies formulated into 

       nanocapsules



<130>  PD10203PC00



<160>  50    



<170>  PatentIn version 3.5



<210>  1

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  1



Cys Gly Asn Lys Arg Thr Arg Gly Cys 

1               5                   





<210>  2

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  2



Cys Gly Asn Lys Arg Thr Arg 

1               5           





<210>  3

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  3



Cys Gly Asn Lys Arg Thr Arg Gly Cys 

1               5                   





<210>  4

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  4



Cys Arg Asn Gly Arg Gly Pro Asp Cys 

1               5                   





<210>  5

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  5



Cys Arg Gly Asp Lys Gly Pro Asp Cys 

1               5                   





<210>  6

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  6



Cys Arg Gly Asp Arg Gly Pro Asp Cys 

1               5                   





<210>  7

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  7



Arg Pro Ala Arg Pro Ala Arg 

1               5           





<210>  8

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  8



Cys Lys Arg Gly Ala Arg Ser Thr Cys 

1               5                   





<210>  9

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  9



Ala Lys Arg Gly Ala Arg Ser Thr Ala 

1               5                   





<210>  10

<211>  462

<212>  PRT

<213>  Antibody polypeptide



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  10



Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 

1               5                   10                  15      





Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 

            20                  25                  30          





Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 

        35                  40                  45              





Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 

    50                  55                  60                  





Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 

65                  70                  75                  80  





Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly 

                85                  90                  95      





Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 

            100                 105                 110         





Tyr Tyr Cys Thr Arg Gly Gly Tyr Gly Tyr Trp Gly Gln Gly Thr Thr 

        115                 120                 125             





Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 

    130                 135                 140                 





Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 

145                 150                 155                 160 





Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 

                165                 170                 175     





Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 

            180                 185                 190         





Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 

        195                 200                 205             





Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 

    210                 215                 220                 





Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 

225                 230                 235                 240 





Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 

                245                 250                 255     





Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 

            260                 265                 270         





Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 

        275                 280                 285             





Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 

    290                 295                 300                 





Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 

305                 310                 315                 320 





Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 

                325                 330                 335     





Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 

            340                 345                 350         





Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 

        355                 360                 365             





Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 

    370                 375                 380                 





Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 

385                 390                 395                 400 





Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 

                405                 410                 415     





Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 

            420                 425                 430         





Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 

        435                 440                 445             





Lys Ser Leu Ser His Ser Pro Gly Lys Leu Ile Gly His Thr 

    450                 455                 460         





<210>  11

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  11



Cys Asp Cys Arg Gly Asp Cys Phe Cys 

1               5                   





<210>  12

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  12



Cys Arg Gly Asp Leu Ala Ser Leu Cys 

1               5                   





<210>  13

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  13



Arg Gly Asp Lys 

1               





<210>  14

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  14



Val Arg Gly Asp 

1               





<210>  15

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  15



Lys Leu Trp Val Leu Pro Lys Gly Gly Gly Cys 

1               5                   10      





<210>  16

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  16



Lys Leu Trp Val Leu Pro Lys Gly Gly Gly Cys 

1               5                   10      





<210>  17

<211>  239

<212>  PRT

<213>  Antibody polypeptide



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  17



Met Arg Cys Ser Leu Gln Phe Leu Gly Val Leu Met Phe Trp Ile Ser 

1               5                   10                  15      





Gly Val Ser Gly Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro 

            20                  25                  30          





Val Ile Ser Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 

        35                  40                  45              





Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg 

    50                  55                  60                  





Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala 

65                  70                  75                  80  





Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 

                85                  90                  95      





Thr Leu Glu Ile Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr 

            100                 105                 110         





Cys Gln Gln Val Val Glu Tyr Pro Arg Thr Phe Gly Ser Gly Thr Lys 

        115                 120                 125             





Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 

    130                 135                 140                 





Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 

145                 150                 155                 160 





Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 

                165                 170                 175     





Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 

            180                 185                 190         





Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 

        195                 200                 205             





Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 

    210                 215                 220                 





Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 

225                 230                 235                 





<210>  18

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  18



Cys Pro Gly Pro Glu Gly Ala Gly Cys 

1               5                   





<210>  19

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  19



Cys Arg Glu Lys Ala 

1               5   





<210>  20

<211>  29

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  20



Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 

1               5                   10                  15      





Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 

            20                  25                  





<210>  21

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  21



Leu Gly Ala Ser Trp His Arg Pro Asp Lys Gly 

1               5                   10      





<210>  22

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  22



Asp Glu Val Asp Gly 

1               5   





<210>  23

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  23



Pro Leu Gly Leu Ala Gly 

1               5       





<210>  24

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  24



Ile Ala Gly Glu Asp Gly Asp Glu Phe Gly 

1               5                   10  





<210>  25

<211>  12

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  25



Arg Arg Arg Arg Arg Arg Arg Arg Gly Arg Gly Asp 

1               5                   10          





<210>  26

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  26



Cys Arg Gly Asp Lys Gly Pro Asp Cys 

1               5                   





<210>  27

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  27



Cys Gly Asn Lys Arg Thr Arg Gly Cys 

1               5                   





<210>  28

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  28



Cys Gly Asn Lys Arg Thr Arg Gly Cys 

1               5                   





<210>  29

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  29



Cys Lys Arg Gly Ala Arg Ser Thr Cys 

1               5                   





<210>  30

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic peptide



<400>  30



Ala Lys Arg Gly Ala Arg Ser Thr Ala 

1               5                   





<210>  31

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  31



Cys Arg Asn Gly Arg Gly Pro Asp Cys 

1               5                   





<210>  32

<211>  31

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  32



Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Ala 

1               5                   10                  15      





Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys 

            20                  25                  30      





<210>  33

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  33



Ser Gly Tyr Tyr Trp Asn 

1               5       





<210>  34

<211>  16

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  34



Tyr Ile Gly Tyr Asp Gly Thr Asn Asn Tyr Asn Pro Ser Leu Lys Asn 

1               5                   10                  15      





<210>  35

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  35



Leu Trp Asp Tyr 

1               





<210>  36

<211>  16

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  36



Arg Ser Ser Gln Thr Ile Val His Gly Asn Gly Asn Thr Tyr Leu Glu 

1               5                   10                  15      





<210>  37

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  37



Thr Val Ser Asn Arg Phe Ser 

1               5           





<210>  38

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  38



Phe Gln Gly Ser His Ala Pro Tyr Thr 

1               5                   





<210>  39

<211>  188

<212>  PRT

<213>  Human KRAS gene 



<220>

<223>  Isoform 2B of GTPase Human KRas



<400>  39



Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 

1               5                   10                  15      





Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 

            20                  25                  30          





Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 

        35                  40                  45              





Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 

    50                  55                  60                  





Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 

65                  70                  75                  80  





Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 

                85                  90                  95      





Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 

            100                 105                 110         





Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 

        115                 120                 125             





Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 

    130                 135                 140                 





Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 

145                 150                 155                 160 





Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 

                165                 170                 175     





Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 

            180                 185             





<210>  40

<211>  12

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  40



Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 

1               5                   10          





<210>  41

<211>  12

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  41



Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 

1               5                   10          





<210>  42

<211>  12

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic sequence



<400>  42



Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys 

1               5                   10          





<210>  43

<211>  467

<212>  PRT

<213>  Antibody polypeptide heavy-chain region



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  43



Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 

1               5                   10                  15      





Leu Ser Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 

            20                  25                  30          





Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 

        35                  40                  45              





Ser Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 

    50                  55                  60                  





Glu Trp Met Gly Tyr Ile Gly Tyr Asp Gly Thr Asn Asn Tyr Asn Pro 

65                  70                  75                  80  





Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 

                85                  90                  95      





Phe Phe Leu Lys Leu Asn Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr 

            100                 105                 110         





Tyr Cys Ala Arg Leu Trp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 

        115                 120                 125             





Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 

    130                 135                 140                 





Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 

145                 150                 155                 160 





Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser 

                165                 170                 175     





Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu 

            180                 185                 190         





Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 

        195                 200                 205             





Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val 

    210                 215                 220                 





Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys 

225                 230                 235                 240 





Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly 

                245                 250                 255     





Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met 

            260                 265                 270         





Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu 

        275                 280                 285             





Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 

    290                 295                 300                 





His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile 

305                 310                 315                 320 





Arg Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 

                325                 330                 335     





Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile 

            340                 345                 350         





Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val 

        355                 360                 365             





Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser 

    370                 375                 380                 





Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu 

385                 390                 395                 400 





Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro 

                405                 410                 415     





Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met 

            420                 425                 430         





Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg 

        435                 440                 445             





His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser 

    450                 455                 460                 





Pro Gly Lys 

465         





<210>  44

<211>  238

<212>  PRT

<213>  Antibody polypeptide light-chain region



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3359



<400>  44



Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 

1               5                   10                  15      





Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 

            20                  25                  30          





Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile 

        35                  40                  45              





Val His Gly Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 

    50                  55                  60                  





Gly Gln Ser Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser 

65                  70                  75                  80  





Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 

                85                  90                  95      





Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 

            100                 105                 110         





Phe Gln Gly Ser His Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 

        115                 120                 125             





Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 

    130                 135                 140                 





Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 

145                 150                 155                 160 





Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 

                165                 170                 175     





Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 

            180                 185                 190         





Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 

        195                 200                 205             





Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 

    210                 215                 220                 





Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 

225                 230                 235             





<210>  45

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  45



Ser Tyr Tyr Met Tyr 

1               5   





<210>  46

<211>  17

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358
<400>  46



Glu Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 

1               5                   10                  15      





Ser 

    





<210>  47

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Hybridoma DSM ACC3358Antibody polypeptide from hybridoma DSM ACC3358
<400>  47



Gly Gly Tyr Gly Tyr 

1               5   





<210>  48

<211>  16

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  48



Arg Ser Ser Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn 

1               5                   10                  15      





<210>  49

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  49



Leu Met Ser Thr Arg Ala Ser 

1               5           





<210>  50

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Antibody polypeptide from hybridoma DSM ACC3358



<400>  50



Gln Gln Val Val Glu Tyr Pro Arg Thr 

1               5                   





