                         SEQUENCE LISTING

<110>  DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN E.V. 
       (DZNE)
 
<120>  Immunogen for preventing or treating familial frontotemporal 
       dementia (FTD) and/or amyotrophic lateral sclerosis (ALS)

<130>  820-3 PCT

<150>  EP 19172392.3
<151>  2019-05-02

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  1
cgcgcgcgcg cg                                                           12


<210>  2
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  2
gggcccgggc cc                                                           12


<210>  3
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  3
ggtggcggtg gc                                                           12


<210>  4
<211>  888
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (321)..(327)
<223>  hexanucleotide repeat that is repeated n-times

<400>  4
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct gcccggttgc ttctcttttg      120

ggggcggggt ctagcaagag caggtgtggg tttaggaggt gtgtgttttt gtttttccca      180

ccctctctcc ccactacttg ctctcacagt actcgctgag ggtgaacaag aaaagacctg      240

ataaagatta accagaagaa aacaaggagg gaaacaaccg cagcctgtag caagctctgg      300

aactcaggag tcgcgcgcta ggggccgggg cgtggtcggg gcgggcccgg gggcgggccc      360

ggggcggggc tgcggttgcg gtgcctgcgc ccgcggcggc ggaggcgcag gcggtggcga      420

gtgggtgagt gaggaggcgg catcctggcg ggtggctgtt tggggttcgg ctgccgggaa      480

gaggcgcggg tagaagcggg ggctctcctc agagctcgac gcatttttac tttccctctc      540

atttctctga ccgaagctgg gtgtcgggct ttcgcctcta gcgactggtg gaattgcctg      600

catccgggcc ccgggcttcc cggcggcggc ggcggcggcg gcggcgcagg gacaagggat      660

ggggatctgg cctcttcctt gctttcccgc cctcagtacc cgagctgtct ccttcccggg      720

gacccgctgg gagcgctgcc gctgcgggct cgagaaaagg gagcctcggg tactgagagg      780

cctcgcctgg gggaaggccg gagggtgggc ggcgcgcggc ttctgcggac caagtcgggg      840

ttcgctagga acccgagacg gtccctgccg gcgaggagat catgcggg                   888


<210>  5
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  5

Trp Ser Gly Arg Ala Arg Gly Arg Ala Arg Gly Gly Ala Ala Val Ala 
1               5                   10                  15      


Val Pro Ala Pro Ala Ala Ala Glu Ala Gln Ala Val Ala Ser Gly 
            20                  25                  30      


<210>  6
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Arg Gly Arg Gly Gly Pro Gly Gly Gly Pro Gly Ala Gly Leu Arg 
1               5                   10                  15      


Leu Arg Cys Leu Arg Pro Arg Arg Arg Arg Arg Arg Arg Trp Arg Val 
            20                  25                  30          


Gly Glu 
        


<210>  7
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Val Val Gly Ala Gly Pro Gly Ala Gly Pro Gly Arg Gly Cys Gly 
1               5                   10                  15      


Cys Gly Ala Cys Ala Arg Gly Gly Gly Gly Ala Gly Gly Gly Glu Trp 
            20                  25                  30          


Val Ser Glu Glu Ala Ala Ser Trp Arg Val Ala Val Trp Gly Ser Ala 
        35                  40                  45              


Ala Gly Lys Arg Arg Gly 
    50                  


<210>  8
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ala Arg Leu Leu Ser Ser Arg Ala Cys Tyr Arg Leu Arg Leu Phe 
1               5                   10                  15      


Pro Ser Leu Phe Ser Ser Gly 
            20              


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Leu Ala Arg Asp Ser 
1               5       


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Ala Leu Glu Leu Arg Ser Arg Ala Leu 
1               5                   10  


<210>  11
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Arg Glu Ser Lys Glu Glu Ala Arg Ser Pro Ser Leu Val Pro Ala 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro Gly Pro Gly Cys Arg 
            20                  25                  30          


Gln Phe His Gln Ser Leu Glu Ala Lys Ala Arg His Pro Ala Ser Val 
        35                  40                  45              


Arg Glu Met Arg Gly Lys Val Lys Met Arg Arg Ala Leu Arg Arg Ala 
    50                  55                  60                  


Pro Ala Ser Thr Arg Ala Ser Ser Arg Gln Pro Asn Pro Lys Gln Pro 
65                  70                  75                  80  


Pro Ala Arg Met Pro Pro Pro His Ser Pro Thr Arg His Arg Leu Arg 
                85                  90                  95      


Leu Arg Arg Arg Gly Arg Arg His Arg Asn Arg Ser Pro Ala Pro Gly 
            100                 105                 110         


Pro Pro Pro Gly Pro Pro Arg Pro Arg Pro 
        115                 120         


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Leu Thr Arg Arg Lys Gln Gly Gly Lys Gln Pro Gln Pro Val Ala 
1               5                   10                  15      


Ser Ser Gly Thr Gln Glu Ser Arg Ala Arg 
            20                  25      


<210>  13
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Glu Pro Pro Leu Leu Pro Ala Pro Leu Pro Gly Ser Arg Thr Pro 
1               5                   10                  15      


Asn Ser His Pro Pro Gly Cys Arg Leu Leu Thr His Pro Leu Ala Thr 
            20                  25                  30          


Ala Cys Ala Ser Ala Ala Ala Gly Ala Gly Thr Ala Thr Ala Ala Pro 
        35                  40                  45              


Pro Arg Ala Arg Pro Arg Ala Arg Pro Asp His 
    50                  55                  


<210>  14
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Pro Arg Arg Gln Gly Pro Ser Arg Val Pro Ser Glu Pro Arg Leu 
1               5                   10                  15      


Gly Pro Gln Lys Pro Arg Ala Ala His Pro Pro Ala Phe Pro Gln Ala 
            20                  25                  30          


Arg Pro Leu Ser Thr Arg Gly Ser Leu Phe Ser Ser Pro Gln Arg Gln 
        35                  40                  45              


Arg Ser Gln Arg Val Pro Gly Lys Glu Thr Ala Arg Val Leu Arg Ala 
    50                  55                  60                  


Gly Lys Gln Ala Arg Met Gln Ala Ile Pro Pro Val Ala Arg Gly Glu 
65                  70                  75                  80  


Ser Pro Thr Pro Ser Phe Gly Gln Arg Asn Glu Arg Glu Ser Lys Asn 
                85                  90                  95      


Ala Ser Ser Ser Glu Glu Ser Pro Arg Phe Tyr Pro Arg Leu Phe Pro 
            100                 105                 110         


Ala Ala Glu Pro Gln Thr Ala Thr Arg Gln Asp Ala Ala Ser Ser Leu 
        115                 120                 125             


Thr His Ser Pro Pro Pro Ala Pro Pro Pro Pro Arg Ala Gln Ala Pro 
    130                 135                 140                 


Gln Pro Gln Pro Arg Pro Gly Pro Ala Pro Gly Pro Ala Pro Thr Thr 
145                 150                 155                 160 


<210>  15
<211>  47
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  amino acids are repeated m-times

<400>  15

Gln Ala Leu Glu Leu Arg Ser Arg Ala Leu Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Trp Ser Gly Arg Ala Arg Gly Arg Ala Arg Gly Gly Ala Ala Val Ala 
            20                  25                  30          


Val Pro Ala Pro Ala Ala Ala Glu Ala Gln Ala Val Ala Ser Gly 
        35                  40                  45          


<210>  16
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  amino acids are repeated o-times

<400>  16

Gly Pro Gly Pro Gly Pro Gly Arg Gly Arg Gly Gly Pro Gly Gly Gly 
1               5                   10                  15      


Pro Gly Ala Gly Leu Arg Leu Arg Cys Leu Arg Pro Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Trp Arg Val Gly Glu 
        35                  40  


<210>  17
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (122)..(123)
<223>  amino acids are repeated o-times

<400>  17

Gly Arg Glu Ser Lys Glu Glu Ala Arg Ser Pro Ser Leu Val Pro Ala 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro Gly Pro Gly Cys Arg 
            20                  25                  30          


Gln Phe His Gln Ser Leu Glu Ala Lys Ala Arg His Pro Ala Ser Val 
        35                  40                  45              


Arg Glu Met Arg Gly Lys Val Lys Met Arg Arg Ala Leu Arg Arg Ala 
    50                  55                  60                  


Pro Ala Ser Thr Arg Ala Ser Ser Arg Gln Pro Asn Pro Lys Gln Pro 
65                  70                  75                  80  


Pro Ala Arg Met Pro Pro Pro His Ser Pro Thr Arg His Arg Leu Arg 
                85                  90                  95      


Leu Arg Arg Arg Gly Arg Arg His Arg Asn Arg Ser Pro Ala Pro Gly 
            100                 105                 110         


Pro Pro Pro Gly Pro Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro 
        115                 120                 125             


<210>  18
<211>  87
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  amino acids repeated p-times

<400>  18

Arg Leu Thr Arg Arg Lys Gln Gly Gly Lys Gln Pro Gln Pro Val Ala 
1               5                   10                  15      


Ser Ser Gly Thr Gln Glu Ser Arg Ala Arg Gly Arg Gly Arg Pro Gly 
            20                  25                  30          


Arg Gly Val Val Gly Ala Gly Pro Gly Ala Gly Pro Gly Arg Gly Cys 
        35                  40                  45              


Gly Cys Gly Ala Cys Ala Arg Gly Gly Gly Gly Ala Gly Gly Gly Glu 
    50                  55                  60                  


Trp Val Ser Glu Glu Ala Ala Ser Trp Arg Val Ala Val Trp Gly Ser 
65                  70                  75                  80  


Ala Ala Gly Lys Arg Arg Gly 
                85          


<210>  19
<211>  88
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (62)..(63)
<223>  amino acids repeated q-times

<400>  19

Gly Glu Pro Pro Leu Leu Pro Ala Pro Leu Pro Gly Ser Arg Thr Pro 
1               5                   10                  15      


Asn Ser His Pro Pro Gly Cys Arg Leu Leu Thr His Pro Leu Ala Thr 
            20                  25                  30          


Ala Cys Ala Ser Ala Ala Ala Gly Ala Gly Thr Ala Thr Ala Ala Pro 
        35                  40                  45              


Pro Arg Ala Arg Pro Arg Ala Arg Pro Asp His Ala Pro Ala Pro Ala 
    50                  55                  60                  


Pro Ser Ala Arg Leu Leu Ser Ser Arg Ala Cys Tyr Arg Leu Arg Leu 
65                  70                  75                  80  


Phe Pro Ser Leu Phe Ser Ser Gly 
                85              


<210>  20
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (186)..(187)
<223>  amino acids are repeated r-times

<400>  20

Ser Pro Arg Arg Gln Gly Pro Ser Arg Val Pro Ser Glu Pro Arg Leu 
1               5                   10                  15      


Gly Pro Gln Lys Pro Arg Ala Ala His Pro Pro Ala Phe Pro Gln Ala 
            20                  25                  30          


Arg Pro Leu Ser Thr Arg Gly Ser Leu Phe Ser Ser Pro Gln Arg Gln 
        35                  40                  45              


Arg Ser Gln Arg Val Pro Gly Lys Glu Thr Ala Arg Val Leu Arg Ala 
    50                  55                  60                  


Gly Lys Gln Gly Arg Gly Gln Ile Pro Ile Pro Cys Pro Cys Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Gly Lys Pro Gly Ala Arg Met Gln Ala Ile 
                85                  90                  95      


Pro Pro Val Ala Arg Gly Glu Ser Pro Thr Pro Ser Phe Gly Gln Arg 
            100                 105                 110         


Asn Glu Arg Glu Ser Lys Asn Ala Ser Ser Ser Glu Glu Ser Pro Arg 
        115                 120                 125             


Phe Tyr Pro Arg Leu Phe Pro Ala Ala Glu Pro Gln Thr Ala Thr Arg 
    130                 135                 140                 


Gln Asp Ala Ala Ser Ser Leu Thr His Ser Pro Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Pro Pro Arg Ala Gln Ala Pro Gln Pro Gln Pro Arg Pro Gly Pro Ala 
                165                 170                 175     


Pro Gly Pro Ala Pro Thr Thr Pro Arg Pro Arg Arg Pro Arg Pro Leu 
            180                 185                 190         


Ala Arg Asp Ser 
        195     


<210>  21
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  amino acid is NLE Norleucine

<400>  21

Gly Xaa Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly 
            20      


