                         SEQUENCE LISTING

<110>  THE GENERAL HOSPITAL CORPORATION
       REVITOPE LIMITED
       COBBOLD, Mark
       PREYER, Martin
       COLTHART, Allison
 
<120>  HALF-LIFE EXTENDED AND/OR SINGLE-AGENT TEAC AND ATTAC IMMUNOONCOLOGY COMPOSITIONS AND METHODS

<130>  29539-0434WO1, 01131-0026-61US

<160>  216   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  1

Lys Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  2

Asp Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  3

Lys Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  4

Leu Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  5

Leu Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  6

Lys Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  7

Tyr Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  8

Lys Trp Ala Lys Phe Phe Arg Leu 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  9

Asp Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  10

Asp Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  11

Asp Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  12

Lys Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  13

Lys Met Ala Met Phe Phe Ile Met 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  14

Lys Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  15

Leu Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  16

Leu Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  17

Leu Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  18

Leu Met Ala Met Phe Phe Ile Met 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  19

Leu Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  20

Leu Pro Ala Met Phe Phe Tyr Met 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  21

Lys Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  22

Lys Pro Ala Lys Phe Phe Tyr Met 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  23

Lys Pro Ala Lys Phe Phe Ile Met 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  24

Ile Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  25

Ile Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  26

Ile Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  27

Ile Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  28

Ile Met Ala Met Phe Phe Ile Met 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  29

Ile Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM28 cleavage site

<400>  30

Ile Pro Ala Met Phe Phe Tyr Met 
1               5               


<210>  31
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  31

Phe Arg 
1       


<210>  32
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  32

Phe Lys 
1       


<210>  33
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  33

Val Ala 
1       


<210>  34
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  34

Val Arg 
1       


<210>  35
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  citrulline

<400>  35

Val 
1   


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  36

His Leu Val Glu Ala Leu Tyr Leu 
1               5               


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  37

Ser Leu Leu Lys Ser Arg Met Val Pro Asn Phe Asn 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  38

Ser Leu Leu Ile Ala Arg Arg Met Pro Asn Phe Asn 
1               5                   10          


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  39

Lys Lys Phe Ala 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  40

Ala Phe Lys Lys 
1               


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin B cleavage site

<400>  41

Gln Gln Gln 
1           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin D cleavage site

<400>  42

Pro Arg Ser Phe Phe Arg Leu Gly Lys 
1               5                   


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin D cleavage site

<400>  43

Ser Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
1               5                   10          


<210>  44
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cathepsin K cleavage site

<400>  44

Gly Gly Pro 
1           


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP1 cleavage site

<400>  45

Ser Leu Gly Pro Gln Gly Ile Trp Gly Gln Phe Asn 
1               5                   10          


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2 cleavage site

<400>  46

Ala Ile Pro Val Ser Leu Arg 
1               5           


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2 cleavage site

<400>  47

Ser Leu Pro Leu Gly Leu Trp Ala Pro Asn Phe Asn 
1               5                   10          


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2 cleavage site

<400>  48

His Pro Val Gly Leu Leu Ala Arg 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2/9 cleavage site

<400>  49

Gly Pro Leu Gly Val Arg Gly Lys 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2 cleavage site

<400>  50

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP3 cleavage site

<400>  51

Ser Thr Ala Val Ile Val Ser Ala 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP7 cleavage site

<400>  52

Gly Pro Leu Gly Leu Ala Arg Lys 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP7 cleavage site

<400>  53

Arg Pro Leu Ala Leu Trp Arg Ser 
1               5               


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP7 cleavage site

<400>  54

Ser Leu Arg Pro Leu Ala Leu Trp Arg Ser Phe Asn 
1               5                   10          


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2/9 cleavage site

<400>  55

Gly Ile Leu Gly Val Pro 
1               5       


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP2/9 cleavage site

<400>  56

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP9 cleavage site

<400>  57

Ala Val Arg Trp Leu Leu Thr Ala 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP9 cleavage site

<400>  58

Pro Leu Gly Leu Tyr Ala Leu 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP9 cleavage site

<400>  59

Gly Pro Gln Gly Ile Ala Gly Gln Arg 
1               5                   


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP9 cleavage site

<400>  60

Lys Pro Val Ser Leu Ser Tyr Arg 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP11 cleavage site

<400>  61

Ala Ala Ala Thr Ser Ile Ala Met 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP11 cleavage site

<400>  62

Ala Ala Gly Ala Met Phe Leu Glu 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP13 cleavage site

<400>  63

Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly Ile Val 
1               5                   10          


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP14 cleavage site

<400>  64

Pro Arg His Leu Arg 
1               5   


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP14 cleavage site

<400>  65

Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly 
1               5                   10          


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MMP14 cleavage site

<400>  66

Pro Arg Ser Ala Lys Glu Leu Arg 
1               5               


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PSA / KLK3

<400>  67

His Ser Ser Lys Leu Gln 
1               5       


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PSA / KLK3

<400>  68

Ser Ser Lys Leu Gln 
1               5   


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: KLK4

<400>  69

Arg Gln Gln Arg 
1               


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: TMPRSS2

<400>  70

Gly Gly Arg 
1           


<210>  71
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Legumain

<400>  71

Ala Ala Asn 
1           


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ST14 (Matriptase)

<400>  72

Gln Ala Arg 
1           


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: C1s cleavage site

<400>  73

Tyr Leu Gly Arg Ser Tyr Lys Val 
1               5               


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: C1s cleavage site


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  74

Met Gln Leu Gly Arg Xaa 
1               5       


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MASP2 cleavage site

<400>  75

Ser Leu Gly Arg Lys Ile Gln Ile 
1               5               


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: C2a and Bb cleavage site

<400>  76

Gly Leu Ala Arg Ser Asn Leu Asp Glu 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: uPa cleavage site

<400>  77

Thr Tyr Ser Arg Ser Arg Tyr Leu 
1               5               


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: uPa cleavage site

<400>  78

Lys Lys Ser Pro Gly Arg Val Val Gly Gly Ser Val 
1               5                   10          


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: uPa cleavage site

<400>  79

Asn Ser Gly Arg Ala Val Thr Tyr 
1               5               


<210>  80
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: uPa cleavage site

<400>  80

Ala Phe Lys 
1           


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: tissue-type plasminogen activator (tPA)

<400>  81

Gly Gly Ser Gly Gln Arg Gly Arg Lys Ala Leu Glu 
1               5                   10          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM10

<400>  82

Pro Arg Tyr Glu Ala Tyr Lys Met Gly Lys 
1               5                   10  


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM12

<400>  83

Leu Ala Gln Ala Phe 
1               5   


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ADAM17

<400>  84

Glu His Ala Asp Leu Leu Ala Val Val Ala Lys 
1               5                   10      


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  85

Gly Gly Gly Gly Ser 
1               5   


<210>  86
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  86

Gly Gly Gly Ser 
1               


<210>  87
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  87

Gly Ser 
1       


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  88

Gly Ser Gly Gly Ser 
1               5   


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  89

Gly Gly Ser Gly 
1               


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  90

Gly Gly Ser Gly Gly 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  91

Gly Ser Gly Ser Gly 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  92

Gly Ser Gly Gly Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  93

Gly Gly Gly Ser Gly 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: flexible amino acid linker (may be presented in 
       repeating fashion)

<400>  94

Gly Ser Ser Ser Gly 
1               5   


<210>  95
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer (tight binder with Kd=2.4 nM)

<400>  95
ugccgcuaua augcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  96
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  96
uggcgcuaaa uagcacggaa auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  97
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  97
ugcuaguaua ucgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  98
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  98
ugccgccaua ucacacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  99
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  99
uuccgcugua uaacacggac uuaaucgccg uaguaaagca ugucaaagcc g                51


<210>  100
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  100
ugucgcucua uugcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  101
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  101
ugcugcuuua ucccacauau uuuuuccccu cauaacaaua uuucuccccc c                51


<210>  102
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<400>  102
ugcngcuaua ucgcncguau uuaaucgccg uagaaaagca ugucnangcc g                51


<210>  103
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  103
ugcaaagaaa acgcacguau uuaaucgccg uaguaaagca ugucaaagcc g                51


<210>  104
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  104
ugcaucacua ucgaaccuau uuaauccacc aaaauaauug caaguccaua cuc              53


<210>  105
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is a, c, g, or u

<400>  105
ugccnnaaua acacacnuau auaaucgccg uacaaaauca ugucaaancc g                51


<210>  106
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  106
ugcagcugua uugcacguau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  107
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  107
uuccgauaau cccgcguacu aaaucaccau agucaacaau uuccaaccuc                  50


<210>  108
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  108
uccacuauau cacacguauu uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  109
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  109
ucccucaacc ucgcuacuau uuaaucgccg uagaaaagca ugucaaagcc u                51


<210>  110
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  110
ugccgcuaua ucacacgaau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  111
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  111
agccccuaga acacacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  112
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  112
ugccaauaua uaacacggaa uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  113
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  113
ugccgcuaua gcgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  114
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  114
ugcagauaua ugucacucau uaauccccgu auaaaaacau aacuaagcuc                  50


<210>  115
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  115
uguagcugua uugcacacau uaaaucgccg uaguaaagca ugucaaagcc g                51


<210>  116
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  116
uaccaauaua ucgccacaca uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  117
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  117
ugccgcuaug cccacggaau uuaaucgccg uagaaaaaca ugucaaaguc g                51


<210>  118
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  118
ugccgcuauu uagcacggau uaaaucgccg uagaaaagca ugucaaagcc g                51


<210>  119
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  119
ugccgcuauu uagcacggau uaaaucgccg uagaaaagca ugucnaagcc g                51


<210>  120
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  n is a, c, g, or u

<400>  120
uguaguaaua ugacacggau uuaaucgccg uagaaaagca ngucaaagcc u                51


<210>  121
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  121
ugucgccauu acgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  122
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  122
ugcccccaaa cuacacaaau uuaaucgccg uauaaaagca ugucaaagcc g                51


<210>  123
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  123
ugcacuaucu cacacguacu aaucgccgua uaaaagcaug ucaaagccg                   49


<210>  124
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  124
ugucgcaaua auacacuaau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  125
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  125
ugcaacaaua uagcacguau uuaaucgccg uaguaaagca ugucaaagg                   49


<210>  126
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  126
cuaccacaaa ucccacauau uuaaucuccc aaucaaaucu uguccauucc c                51


<210>  127
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  127
ugcccuaaac ucacacggau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  128
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  128
uugucguaug ucacacguau uaaaucgccg uauaaaagca ugucaaagcc g                51


<210>  129
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  129
uuccgcuaua acacacggag aaaaucgccg uaguaaagca ugucaaagcc g                51


<210>  130
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  130
ugccgauaua acgcacggau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  131
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  131
ugccauuaua cagcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  132
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  132
uccagaaaua ugcacacauu uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  133
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  133
uccgcuaaac aacacggaua caaucgccgu agaaaagcau guccaagccg                  50


<210>  134
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a, c, g, or u

<400>  134
ugcacuaucu cacacguacu aaucgccgua uaaaagcaug ucaaannng                   49


<210>  135
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  135
aungcnannn uacacguauu naaucgccgu agaaaagcau gucanagccg                  50


<210>  136
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  136
ugcugcuaua uugcaauuuu uuaaacuaag uagaaaacca uguacaaguc g                51


<210>  137
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  137
ugucgccaua uugcacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  138
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  138
ugccguuaua acccacggaa uuuaaccucc guagaaaagc augucaaagc cg               52


<210>  139
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or u

<400>  139
ugugaauaua uaucacggau uuaaucgccg uauaaaagcn augucaaagc cg               52


<210>  140
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or u

<400>  140
ugccgauaun nancacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  141
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  141
ugucacuaaa uugcacguau auaaucgccg uaguaagcau gucaaagccg                  50


<210>  142
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  142
ugcaaccaua aagcacguaa uaaaucgccg uauauaagca ugucaaagcc g                51


<210>  143
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  143
ugccgcuaua uagcacguau uaaucgccgu aguaaagcau gucaaagccg                  50


<210>  144
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  144
ugccgcuaua gcacacggaa uuuaaucgcc guaguaaagc augucaaagc cg               52


<210>  145
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  145
ugcagguaua uaacncggau uuaaucgccg uagaaaagca ugucnaagcc g                51


<210>  146
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  146
ugcuccuaua acacacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  147
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  147
ugcccguaau ugcacggauu uaaucgccgu agaaaagcau guccaagccg g                51


<210>  148
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is a, c, g, or u

<400>  148
acucccuaua ungcaacuac auaaucgccg uaaauaagca uguncaagcc g                51


<210>  149
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  149
ugaagcuaga ucacacuaaa uuaaucgccg uagaaaagca ugucaaaaaa gccg             54


<210>  150
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  150
ugacucuuua ucccccguac auuauucacc gaaccaaagc auuaccaucc cc               52


<210>  151
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  151
ugacgcccua acacacguau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  152
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  152
ugucgcaaaa uagcacguau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  153
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  153
ugaguguaua auucacguau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  154
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  154
ugcuacuaua ucguagguaa cuaaucgccc uacaaacuca cucuaaaacc g                51


<210>  155
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  155
uuacgcuaua ucacacggaa uuuuaaucgc cguagaaaag cauguccaag ccg              53


<210>  156
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  156
cccaucugua cuacaggaau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  157
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  157
ugcccauaaa uagcacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  158
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  158
ugccgcaaua acauacacau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  159
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  159
ugcaacuaua ucgcacguau guaaucgccg uagaaaaagc augucaaagc c                51


<210>  160
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  160
uuccgcuaua uagcacggaa uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  161
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  161
uuccgcuaag ucacacgaaa uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  162
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  162
uguagcaaua ucacacguaa uuaaucgccg uauauaagca ugucaaagcc g                51


<210>  163
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  163
ugccguuaua uaucacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  164
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EGFR aptamer

<400>  164
uaacacauau aucaaguaac uuaucuccuu aguaaccauc uccaagccg                   49


<210>  165
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 6248 single chain; scFv anti-EPCAM

<400>  165

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                325                 330                 335     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro 
    370                 375                 380                 


Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                405                 410                 415     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
        435                 440                 445             


Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
465                 470                 475                 480 


Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Cys Pro 
            500                 505                 510         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        515                 520                 525             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    530                 535                 540                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
545                 550                 555                 560 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                565                 570                 575     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            580                 585                 590         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        595                 600                 605             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    610                 615                 620                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
625                 630                 635                 640 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                645                 650                 655     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            660                 665                 670         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        675                 680                 685             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    690                 695                 700                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
705                 710                 715                 720 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730     


<210>  166
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 6249 single chain; scFv anti-EPCAM

<400>  166

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            260                 265                 270         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        275                 280                 285             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    290                 295                 300                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly 
        355                 360                 365             


Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp 
    370                 375                 380                 


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
                405                 410                 415     


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            420                 425                 430         


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Asp Phe Leu Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
                485                 490                 495     


Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            500                 505                 510         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        515                 520                 525             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    530                 535                 540                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
545                 550                 555                 560 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                565                 570                 575     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            580                 585                 590         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        595                 600                 605             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    610                 615                 620                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
625                 630                 635                 640 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                645                 650                 655     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            660                 665                 670         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        675                 680                 685             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    690                 695                 700                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
705                 710                 715                 720 


Lys Ser Leu Ser Leu Ser Pro Gly 
                725             


<210>  167
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 9329 Glypican3 VHH-CD3E(VH-MMP2-VL)

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
                245                 250                 255     


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            260                 265                 270         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        275                 280                 285             


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
305                 310                 315                 320 


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    370                 375                 380                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
385                 390                 395                 400 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                405                 410                 415     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            420                 425                 430         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        435                 440                 445             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    450                 455                 460                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
465                 470                 475                 480 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                485                 490                 495     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            500                 505                 510         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        515                 520                 525             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    530                 535                 540                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
545                 550                 555                 560 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                565                 570                 575     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            580                 585                 590         


Lys Ser Leu Ser Leu Ser Pro Gly 
        595                 600 


<210>  168
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 9330

<400>  168

Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
        115                 120                 125             


Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala Ser Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp Ile Glu Trp Val 
145                 150                 155                 160 


Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro 
                165                 170                 175     


Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
            180                 185                 190         


Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln Met Gln Leu Ser Ser 
        195                 200                 205             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr 
    210                 215                 220                 


Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
                245                 250                 255     


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            260                 265                 270         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
        275                 280                 285             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    290                 295                 300                 


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                325                 330                 335     


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
            340                 345                 350         


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        355                 360                 365             


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
    370                 375                 380                 


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        435                 440                 445             


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            500                 505                 510         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        515                 520                 525             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    530                 535                 540                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
545                 550                 555                 560 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                565                 570                 575     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            580                 585                 590         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        595                 600                 605             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    610                 615                 620                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
625                 630                 635                 640 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                645                 650                 655     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            660                 665                 670         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        675                 680                 685             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    690                 695                 700                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
705                 710                 715                 720 


Lys Ser Leu Ser Leu Ser Pro Gly 
                725             


<210>  169
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 9334 EGFR VHH-CD3E(VH-MMP2-VL)

<400>  169

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
145                 150                 155                 160 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
        195                 200                 205             


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
225                 230                 235                 240 


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
                245                 250                 255     


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
        275                 280                 285             


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
    290                 295                 300                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
305                 310                 315                 320 


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
                325                 330                 335     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
            340                 345                 350         


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        355                 360                 365             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
    370                 375                 380                 


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
385                 390                 395                 400 


Thr Lys Val Glu Ile Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    450                 455                 460                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    530                 535                 540                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        595                 600                 605             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 


Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630         


<210>  170
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 9335 EGFR VHH-CD3E(VL-MMP2-VH)

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
        195                 200                 205             


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly 
            260                 265                 270         


Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp 
        275                 280                 285             


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    290                 295                 300                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
305                 310                 315                 320 


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                325                 330                 335     


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
            340                 345                 350         


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
        355                 360                 365             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Ala Arg Asp Phe Leu Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    450                 455                 460                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    530                 535                 540                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        595                 600                 605             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 


Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630         


<210>  171
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP058, anti-Epcam kappa light chain

<400>  171

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  172
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP111, anti-EGFR H-TEAC heavy chain

<400>  172

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val 
            20                  25                  30          


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
        35                  40                  45              


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                85                  90                  95      


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu 
            100                 105                 110         


Trp Tyr Ser Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
        195                 200                 205             


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
    210                 215                 220                 


Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
                245                 250                 255     


Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        275                 280                 285             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
    290                 295                 300                 


Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                325                 330                 335     


Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            340                 345                 350         


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        355                 360                 365             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro 
    370                 375                 380                 


Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys His His His His His His 
            500                 505                 510         


<210>  173
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP112, anti-EGFR L-TEAC heavy chain

<400>  173

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Val Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly 
        115                 120                 125             


Tyr Val Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
                165                 170                 175     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
            180                 185                 190         


Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp 
    210                 215                 220                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
225                 230                 235                 240 


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
                245                 250                 255     


Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            260                 265                 270         


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        275                 280                 285             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
    290                 295                 300                 


Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn 
                325                 330                 335     


Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val 
            340                 345                 350         


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
        355                 360                 365             


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser 
    370                 375                 380                 


Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys His His His His His 
            500                 505                 510         


His 
    


<210>  174
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP113, anti-EGFR kappa light chain

<400>  174

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Phe Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  175
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP251, anti-Epcam H-TEAC SG3SG4S-linker Fc fusion 
       heavy chain

<400>  175

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
            260                 265                 270         


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
        275                 280                 285             


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
    290                 295                 300                 


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
                325                 330                 335     


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
            340                 345                 350         


Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
                405                 410                 415     


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
    450                 455                 460                 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
                485                 490                 495     


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg 
        515                 520                 525             


Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
    530                 535                 540                 


Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu 
545                 550                 555                 560 


Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn 
                565                 570                 575     


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
            580                 585                 590         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val 
        595                 600                 605             


Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp 
    610                 615                 620                 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
625                 630                 635                 640 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                645                 650                 655     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            660                 665                 670         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        675                 680                 685             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    690                 695                 700                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
705                 710                 715                 720 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                725                 730                 735     


Cys 
    


<210>  176
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP252, anti-Epcam H-TEAC SG3SG4AG4S linker Fc fusion 
       heavy chain

<400>  176

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
            260                 265                 270         


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
        275                 280                 285             


Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp 
305                 310                 315                 320 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                325                 330                 335     


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            340                 345                 350         


Leu Trp Tyr Ser Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr 
        355                 360                 365             


Val Leu Gly Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala 
    370                 375                 380                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
        435                 440                 445             


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                485                 490                 495     


Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            500                 505                 510         


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly 
        515                 520                 525             


Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Ala Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg 
545                 550                 555                 560 


Pro Gly His Gly Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly 
                565                 570                 575     


Asn Ile His Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala 
            580                 585                 590         


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe 
        595                 600                 605             


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu 
    610                 615                 620                 


Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
625                 630                 635                 640 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                645                 650                 655     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            660                 665                 670         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        675                 680                 685             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    690                 695                 700                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
705                 710                 715                 720 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                725                 730                 735     


Val Glu Pro Lys Ser Cys 
            740         


<210>  177
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP253, anti-Epcam H-TEAC SG3SG4AG4S linker Fc fusion 
       heavy chain

<400>  177

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
            260                 265                 270         


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
        275                 280                 285             


Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp 
305                 310                 315                 320 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                325                 330                 335     


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            340                 345                 350         


Leu Trp Tyr Ser Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr 
        355                 360                 365             


Val Leu Gly Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Glu Val Gln 
    370                 375                 380                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
385                 390                 395                 400 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
                405                 410                 415     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
            420                 425                 430         


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
        435                 440                 445             


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu 
    450                 455                 460                 


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
465                 470                 475                 480 


Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 
            500                 505                 510         


Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
        515                 520                 525             


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
    530                 535                 540                 


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
545                 550                 555                 560 


Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys Phe 
                565                 570                 575     


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
            580                 585                 590         


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys 
        595                 600                 605             


Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln Gly 
    610                 615                 620                 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
625                 630                 635                 640 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                645                 650                 655     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            660                 665                 670         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        675                 680                 685             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    690                 695                 700                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
705                 710                 715                 720 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                725                 730                 


<210>  178
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP254, anti-Epcam H-TEAC SG3SG4AG4S linker Fc fusion 
       heavy chain

<400>  178

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
            260                 265                 270         


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
        275                 280                 285             


Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp 
305                 310                 315                 320 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                325                 330                 335     


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            340                 345                 350         


Leu Trp Tyr Ser Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr 
        355                 360                 365             


Val Leu Gly Gly Pro Leu Gly Val Arg Gly Gly Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
            420                 425                 430         


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
        435                 440                 445             


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met 
    450                 455                 460                 


Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
465                 470                 475                 480 


Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln 
            500                 505                 510         


Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val 
        515                 520                 525             


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Trp Leu 
    530                 535                 540                 


Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Asp 
545                 550                 555                 560 


Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys Phe Lys Gly 
                565                 570                 575     


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
            580                 585                 590         


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
        595                 600                 605             


Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr 
    610                 615                 620                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
625                 630                 635                 640 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                645                 650                 655     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            660                 665                 670         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        675                 680                 685             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    690                 695                 700                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
705                 710                 715                 720 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                725                 730         


<210>  179
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP268, anti-EGFR H-TEAC SG3SG4S-linker Fc fusion heavy
       chain

<400>  179

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
            260                 265                 270         


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
        275                 280                 285             


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
    290                 295                 300                 


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
                325                 330                 335     


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
            340                 345                 350         


Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
                405                 410                 415     


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
    450                 455                 460                 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
                485                 490                 495     


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
        515                 520                 525             


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
    530                 535                 540                 


Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro 
545                 550                 555                 560 


Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr 
                565                 570                 575     


Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp 
            580                 585                 590         


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
        595                 600                 605             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr 
    610                 615                 620                 


Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
625                 630                 635                 640 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                645                 650                 655     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            660                 665                 670         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        675                 680                 685             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    690                 695                 700                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
705                 710                 715                 720 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                725                 730                 735     


Val Glu Pro Lys Ser Cys His His His His His His 
            740                 745             


<210>  180
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MP269, anti-EGFR L-TEAC SG3SG4S-linker Fc Fusion heavy
       chain

<400>  180

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
            340                 345                 350         


Val Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr 
        355                 360                 365             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                405                 410                 415     


Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ala 
            420                 425                 430         


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        435                 440                 445             


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly 
465                 470                 475                 480 


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                485                 490                 495     


Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        515                 520                 525             


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly 
                565                 570                 575     


Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
            580                 585                 590         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        595                 600                 605             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr 
    610                 615                 620                 


Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
625                 630                 635                 640 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                645                 650                 655     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            660                 665                 670         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        675                 680                 685             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    690                 695                 700                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
705                 710                 715                 720 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                725                 730                 735     


Lys Val Glu Pro Lys Ser Cys His His His His His His 
            740                 745                 


<210>  181
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 19-mer protease linker

<400>  181

Gly Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  182
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 11-mer protease linker

<400>  182

Gly Gly Pro Leu Gly Val Arg Gly Lys Ala Gly 
1               5                   10      


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 9-mer protease linker

<400>  183

Gly Gly Pro Leu Gly Val Arg Gly Gly 
1               5                   


<210>  184
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SG3SG4AG4S linker

<400>  184

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SG3SG4S linker

<400>  185

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  186
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM-CD3 VH ATTAC/TEAC component with half-life 
       extension   (Anti-EpCAM scFv with 3xG4S linker between VH-VL  
       1xG4S connector  anti-CD3e VH (20G6) - MMP2 cleavage sequence  Ig
       VL domain  human IgG1 Fc)

<400>  186

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile 
    290                 295                 300                 


Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
                325                 330                 335     


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
            340                 345                 350         


Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala 
    370                 375                 380                 


Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp 
385                 390                 395                 400 


Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln 
                405                 410                 415     


Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser Ser 
            420                 425                 430         


Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        435                 440                 445             


Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Ser 
                485                 490                 495     


His Val Gly Pro Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Asp 
            500                 505                 510         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        515                 520                 525             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    530                 535                 540                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
545                 550                 555                 560 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                565                 570                 575     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            580                 585                 590         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        595                 600                 605             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    610                 615                 620                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
625                 630                 635                 640 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                645                 650                 655     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            660                 665                 670         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        675                 680                 685             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    690                 695                 700                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
705                 710                 715                 720 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                725                 730                 735     


Gly 
    


<210>  187
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM-CD3 VH ATTAC/TEAC component with half-life 
       extension moiety  Anti-EpCAM scFv (with 3xG4S linker between 
       VH-VL)  1xG4S connector  20G6 VH  MMP2 cleavage tag  inert 
       binding partner (VL domain)  2xG4S linker  IgG4 CH domains  His 
       

<400>  187

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile 
    290                 295                 300                 


Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
                325                 330                 335     


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
            340                 345                 350         


Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala 
    370                 375                 380                 


Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp 
385                 390                 395                 400 


Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln 
                405                 410                 415     


Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser Ser 
            420                 425                 430         


Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        435                 440                 445             


Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Ser 
                485                 490                 495     


His Val Gly Pro Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
        515                 520                 525             


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
    530                 535                 540                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
545                 550                 555                 560 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
                565                 570                 575     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            580                 585                 590         


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        595                 600                 605             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    610                 615                 620                 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
625                 630                 635                 640 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
                645                 650                 655     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            660                 665                 670         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        675                 680                 685             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    690                 695                 700                 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
705                 710                 715                 720 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                725                 730                 735     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser His His 
            740                 745                 750         


His His His His 
        755     


<210>  188
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM-CD3 VL ATTAC/TEAC component with half-life 
       extension moiety   (Anti-EpCAM scFv with 3xG4S linker between 
       VH-VL  1xG4S connector  anti-CD3e VL (20G6) - MMP2 cleavage 
       sequence  Ig VH domain  human IgG1 Fc)

<400>  188

Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
            260                 265                 270         


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn 
        275                 280                 285             


Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser 
    290                 295                 300                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                325                 330                 335     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr 
            340                 345                 350         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly 
        355                 360                 365             


Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gln Leu Glu Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys 
        435                 440                 445             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
    450                 455                 460                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser 
                485                 490                 495     


Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        515                 520                 525             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    530                 535                 540                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
545                 550                 555                 560 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                565                 570                 575     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            580                 585                 590         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        595                 600                 605             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    610                 615                 620                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
625                 630                 635                 640 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                645                 650                 655     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            660                 665                 670         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        675                 680                 685             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    690                 695                 700                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
705                 710                 715                 720 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                725                 730                 735     


Pro Gly 
        


<210>  189
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM-CD3 VL ATTAC/TEAC component with half-life 
       extension moiety  Anti-EpCAM scFv (with 3xG4S linker between 
       VL-VH)  1xG4S connector  20G6 VL  MMP2 cleavage tag  inert 
       binding partner (VH domain)  2xG4S linker  IgG4 CH domains  EPEA 
       

<400>  189

Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
            260                 265                 270         


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn 
        275                 280                 285             


Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser 
    290                 295                 300                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                325                 330                 335     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr 
            340                 345                 350         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly 
        355                 360                 365             


Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gln Leu Glu Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys 
        435                 440                 445             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
    450                 455                 460                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser 
                485                 490                 495     


Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
        515                 520                 525             


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
    530                 535                 540                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
545                 550                 555                 560 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
                565                 570                 575     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            580                 585                 590         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        595                 600                 605             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    610                 615                 620                 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
625                 630                 635                 640 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                645                 650                 655     


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            660                 665                 670         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        675                 680                 685             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    690                 695                 700                 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
705                 710                 715                 720 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                725                 730                 735     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Glu Pro 
            740                 745                 750         


Glu Ala 
        


<210>  190
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM-CD3 scFv (20G6) BiTE construct (anti-EpCAM 
       scFv with 3xG4S linker between VH and VL  1xG4S connector  
       anti-CD3 scFv with linker between VH and VL )

<400>  190

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
            260                 265                 270         


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn 
        275                 280                 285             


Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser 
    290                 295                 300                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                325                 330                 335     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr 
            340                 345                 350         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly 
        355                 360                 365             


Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln 
    370                 375                 380                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp 
                405                 410                 415     


Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala 
            420                 425                 430         


Gln Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser 
            500                 


<210>  191
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component with half-life 
       extension moiety   (Anti-CD8 VHH 1xG4S connector  anti-CD3e VL 
       (20G6) - MMP2 cleavage sequence  Ig VH domain  human IgG1 Fc)  
       (CD8 targeting VHH domain based upon WO_2017_134306 SEQ ID NO: 
       

<400>  191

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Trp Asn Gly Gly Ser Ala Glu Tyr Ala Glu Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Asp Leu Val Trp Tyr Asn Leu Arg Thr Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu Ser 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr Lys 
            180                 185                 190         


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr Pro Phe Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly 
                245                 250                 255     


Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly 
            260                 265                 270         


Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        275                 280                 285             


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    290                 295                 300                 


Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu 
305                 310                 315                 320 


Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser Ser Ala Phe Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His 
385                 390                 395                 400 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                405                 410                 415     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            420                 425                 430         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        435                 440                 445             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    450                 455                 460                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
465                 470                 475                 480 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                485                 490                 495     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            500                 505                 510         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        515                 520                 525             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    530                 535                 540                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
545                 550                 555                 560 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                565                 570                 575     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            580                 585                 590         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        595                 600                 605             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    610                 615                 620         


<210>  192
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component with half-life 
       extension moiety

<400>  192

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Trp Asn Gly Gly Ser Ala Glu Tyr Ala Glu Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Asp Leu Val Trp Tyr Asn Leu Arg Thr Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu Ser 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr Lys 
            180                 185                 190         


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr Pro Phe Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly 
                245                 250                 255     


Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly 
            260                 265                 270         


Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        275                 280                 285             


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    290                 295                 300                 


Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu 
305                 310                 315                 320 


Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser Ser Ala Phe Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
                405                 410                 415     


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    450                 455                 460                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    530                 535                 540                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        595                 600                 605             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly His His His His His His 
625                 630                 635                 640 


<210>  193
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component with half-life 
       extension moiety

<400>  193

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu 
    130                 135                 140                 


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg 
145                 150                 155                 160 


Ser Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
                165                 170                 175     


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
    210                 215                 220                 


Asn Glu Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu 
                245                 250                 255     


Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
            260                 265                 270         


Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln 
        275                 280                 285             


Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr Lys Val Ser Asn Arg 
    290                 295                 300                 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
305                 310                 315                 320 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
                325                 330                 335     


Tyr Cys Gly Gln Gly Thr Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr 
            340                 345                 350         


Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile 
        355                 360                 365             


Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln Val 
    370                 375                 380                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
385                 390                 395                 400 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
                405                 410                 415     


His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln 
            420                 425                 430         


Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
465                 470                 475                 480 


Glu Arg Gly His Tyr Tyr Asp Ser Ser Ala Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
625                 630                 635                 640 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730 


<210>  194
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component with half-life 
       extension moiety

<400>  194

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu 
    130                 135                 140                 


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg 
145                 150                 155                 160 


Ser Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
                165                 170                 175     


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
    210                 215                 220                 


Asn Glu Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu 
                245                 250                 255     


Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
            260                 265                 270         


Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln 
        275                 280                 285             


Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr Lys Val Ser Asn Arg 
    290                 295                 300                 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
305                 310                 315                 320 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
                325                 330                 335     


Tyr Cys Gly Gln Gly Thr Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr 
            340                 345                 350         


Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile 
        355                 360                 365             


Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln Val 
    370                 375                 380                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
385                 390                 395                 400 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
                405                 410                 415     


His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln 
            420                 425                 430         


Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
465                 470                 475                 480 


Glu Arg Gly His Tyr Tyr Asp Ser Ser Ala Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            500                 505                 510         


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
        515                 520                 525             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
    610                 615                 620                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Leu Gly Lys Gly His His His His His His 
            740                 745             


<210>  195
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD4-CD3 VL ATTAC component with half-life 
       extension moiety

<400>  195

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu 
    210                 215                 220                 


Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile 
                245                 250                 255     


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
            260                 265                 270         


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly 
        275                 280                 285             


Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
    290                 295                 300                 


Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
                325                 330                 335     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln 
            340                 345                 350         


Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu 
        355                 360                 365             


Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Gln Leu Glu Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn 
        435                 440                 445             


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp 
                485                 490                 495     


Ser Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        515                 520                 525             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    530                 535                 540                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
545                 550                 555                 560 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                565                 570                 575     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            580                 585                 590         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        595                 600                 605             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    610                 615                 620                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
625                 630                 635                 640 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                645                 650                 655     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            660                 665                 670         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        675                 680                 685             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    690                 695                 700                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
705                 710                 715                 720 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                725                 730                 735     


Ser Pro Gly 
            


<210>  196
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD4-CD3 VL ATTAC component with half-life 
       extension moiety

<400>  196

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu 
    210                 215                 220                 


Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile 
                245                 250                 255     


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
            260                 265                 270         


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly 
        275                 280                 285             


Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
    290                 295                 300                 


Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
                325                 330                 335     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln 
            340                 345                 350         


Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu 
        355                 360                 365             


Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Gln Leu Glu Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn 
        435                 440                 445             


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp 
                485                 490                 495     


Ser Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro 
        515                 520                 525             


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
    530                 535                 540                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
545                 550                 555                 560 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                565                 570                 575     


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            580                 585                 590         


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
        595                 600                 605             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    610                 615                 620                 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
625                 630                 635                 640 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                645                 650                 655     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            660                 665                 670         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        675                 680                 685             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    690                 695                 700                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
705                 710                 715                 720 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                725                 730                 735     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly His 
            740                 745                 750         


His His His His His 
        755         


<210>  197
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component   (Anti-CD8 VHH 6xG4S 
       connector  anti-CD3e VL (20G6) - Enterokinase cleavage sequence  
       Ig VH domain  human IgG1 Fc)  (CD8 targeting VHH domain based 
       upon WO_2017_134306 SEQ ID NO: 21)

<400>  197

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Val Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Leu Tyr Thr Cys Val Gln Ser Ile Val Trp Pro Ala 
            100                 105                 110         


Arg Pro Tyr Tyr Asp Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                165                 170                 175     


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
            180                 185                 190         


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly 
        195                 200                 205             


Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
    210                 215                 220                 


Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
                245                 250                 255     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln 
            260                 265                 270         


Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu 
        275                 280                 285             


Gly Thr Ser Thr Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Gln Ser 
                325                 330                 335     


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
            340                 345                 350         


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln 
        355                 360                 365             


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn 
    370                 375                 380                 


Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr 
385                 390                 395                 400 


Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
                405                 410                 415     


Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu 
            420                 425                 430         


Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        435                 440                 445             


Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    450                 455                 460                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
465                 470                 475                 480 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                485                 490                 495     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            500                 505                 510         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        515                 520                 525             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    530                 535                 540                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
545                 550                 555                 560 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                565                 570                 575     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            580                 585                 590         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        595                 600                 605             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    610                 615                 620                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
625                 630                 635                 640 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                645                 650                 655     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            660                 665                 670         


Ser Leu Ser Pro Gly 
        675         


<210>  198
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component   (Anti-CD8 VHH 6xG4S 
       connector  anti-CD3e VL (20G6) - Enterokinase cleavage sequence  
       Ig VH domain  2xG4S connector  IgG4 CH domains  His tag)  (CD8 
       targeting VHH domain based upon WO_2017_134306 SEQ ID NO: 21)

<400>  198

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Val Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Leu Tyr Thr Cys Val Gln Ser Ile Val Trp Pro Ala 
            100                 105                 110         


Arg Pro Tyr Tyr Asp Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                165                 170                 175     


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
            180                 185                 190         


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly 
        195                 200                 205             


Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
    210                 215                 220                 


Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
                245                 250                 255     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln 
            260                 265                 270         


Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu 
        275                 280                 285             


Gly Thr Ser Thr Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Gln Ser 
                325                 330                 335     


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
            340                 345                 350         


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln 
        355                 360                 365             


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn 
    370                 375                 380                 


Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr 
385                 390                 395                 400 


Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
                405                 410                 415     


Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu 
            420                 425                 430         


Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        435                 440                 445             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro 
    450                 455                 460                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
465                 470                 475                 480 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                485                 490                 495     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            500                 505                 510         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        515                 520                 525             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    530                 535                 540                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
545                 550                 555                 560 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                565                 570                 575     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            580                 585                 590         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        595                 600                 605             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    610                 615                 620                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
625                 630                 635                 640 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                645                 650                 655     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            660                 665                 670         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser 
        675                 680                 685             


His His His His His His 
    690                 


<210>  199
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD33 TEAC component with half-life extension 
       moiety  CD33 20G6-VH  Anti-CD33 scFv (with 3xG4S linker between 
       VH-VL)  1xG4S connector  20G6 VH  MMP2 cleavage tag  inert 
       binding partner (VL domain)  2xG4S linker  IgG4 CH domains  His 
       

<400>  199

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr 
                165                 170                 175     


Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gly Val Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                245                 250                 255     


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr 
            260                 265                 270         


Lys Ala Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu 
        275                 280                 285             


Trp Val Ala Gln Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr 
    290                 295                 300                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
305                 310                 315                 320 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
            340                 345                 350         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Gly Thr Ser 
        355                 360                 365             


Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Gly Ala Asp Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
385                 390                 395                 400 


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
                405                 410                 415     


Ile Val His Ser Ser Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
            420                 425                 430         


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
        435                 440                 445             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
465                 470                 475                 480 


Cys Gly Gln Gly Ser His Val Gly Pro Thr Phe Gly Ser Gly Thr Lys 
                485                 490                 495     


Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr 
            500                 505                 510         


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
545                 550                 555                 560 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
                725                 730                 735     


Lys Gly Ser His His His His His His 
            740                 745 


<210>  200
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD123 TEAC component with half-life extension 
       moiety  CD123 20G6-VL  Anti-CD123 VHH domain  1xG4S connector  
       20G6 VL  MMP2 cleavage tag  inert binding partner (VH domain)  
       2xG4S linker  IgG4 CH domains  EPEA tag - Stop

<400>  200

Glu Val Gln Leu Val Lys Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 
        115                 120                 125             


Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys 
    130                 135                 140                 


Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu Ser Trp 
145                 150                 155                 160 


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr Lys Val 
                165                 170                 175     


Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
        195                 200                 205             


Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr Pro Phe Thr Phe Gly 
    210                 215                 220                 


Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser 
225                 230                 235                 240 


Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala 
                245                 250                 255     


Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
            260                 265                 270         


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
        275                 280                 285             


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp 
    290                 295                 300                 


Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser Ser Ala Phe Asp Tyr 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                485                 490                 495     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Leu Gly Lys Gly Glu Pro Glu Ala 
    610                 615                 620     


<210>  201
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM VL TEAC component with half-life extension 
       moiety

<400>  201

Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
            260                 265                 270         


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn 
        275                 280                 285             


Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser 
    290                 295                 300                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                325                 330                 335     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr 
            340                 345                 350         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly 
        355                 360                 365             


Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu Arg Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gln Leu Glu Trp Val Ala Gln Ile Ser Phe Asp Gly Ser Asn Lys 
        435                 440                 445             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
    450                 455                 460                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Ser Glu Arg Gly His Tyr Tyr Asp Ser 
                485                 490                 495     


Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
        515                 520                 525             


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
    530                 535                 540                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
545                 550                 555                 560 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
                565                 570                 575     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            580                 585                 590         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        595                 600                 605             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    610                 615                 620                 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
625                 630                 635                 640 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                645                 650                 655     


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            660                 665                 670         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        675                 680                 685             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    690                 695                 700                 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
705                 710                 715                 720 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                725                 730                 735     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Glu Pro 
            740                 745                 750         


Glu Ala 
        


<210>  202
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-EpCAM VH TEAC component with half-life extension 
       moiety

<400>  202

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile 
    290                 295                 300                 


Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
                325                 330                 335     


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
            340                 345                 350         


Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala 
    370                 375                 380                 


Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp 
385                 390                 395                 400 


Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln 
                405                 410                 415     


Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser Ser 
            420                 425                 430         


Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        435                 440                 445             


Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Ser 
                485                 490                 495     


His Val Gly Pro Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
        515                 520                 525             


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
    530                 535                 540                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
545                 550                 555                 560 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
                565                 570                 575     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            580                 585                 590         


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        595                 600                 605             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    610                 615                 620                 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
625                 630                 635                 640 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
                645                 650                 655     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            660                 665                 670         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        675                 680                 685             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    690                 695                 700                 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
705                 710                 715                 720 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                725                 730                 735     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser His His 
            740                 745                 750         


His His His His 
        755     


<210>  203
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO258, anti-EpCAM H-TEAC SG3SG4S-linker Fc fusion

<400>  203

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
225                 230                 235                 240 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                245                 250                 255     


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
            260                 265                 270         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        275                 280                 285             


Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    290                 295                 300                 


Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
305                 310                 315                 320 


Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Ala Val Phe 
                325                 330                 335     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly Ser Glu Val Gln Leu 
        355                 360                 365             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    370                 375                 380                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
385                 390                 395                 400 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                405                 410                 415     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
            420                 425                 430         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln 
        435                 440                 445             


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    450                 455                 460                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 
                485                 490                 495     


Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser 
            500                 505                 510         


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Trp 
        515                 520                 525             


Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys Phe Lys 
545                 550                 555                 560 


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
                565                 570                 575     


Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln Gly Thr 
        595                 600                 605             


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    610                 615                 620                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
625                 630                 635                 640 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                645                 650                 655     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            660                 665                 670         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        675                 680                 685             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    690                 695                 700                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
705                 710                 715         


<210>  204
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO259, anti-EpCAM H-TEAC SG3SG4AG4S-linker Fc fusion

<400>  204

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                245                 250                 255     


Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            260                 265                 270         


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        275                 280                 285             


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly 
305                 310                 315                 320 


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                325                 330                 335     


Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly 
        355                 360                 365             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    370                 375                 380                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 
385                 390                 395                 400 


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                405                 410                 415     


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
            420                 425                 430         


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
        435                 440                 445             


Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp 
465                 470                 475                 480 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
            500                 505                 510         


Arg Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        515                 520                 525             


Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr 
545                 550                 555                 560 


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                565                 570                 575     


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    610                 615                 620                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
625                 630                 635                 640 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                645                 650                 655     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            660                 665                 670         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        675                 680                 685             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    690                 695                 700                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
705                 710                 715                 720 


Ser Cys 
        


<210>  205
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO260, anti-EpCAM H-TEAC SG3SG4AG4S-linker Fc fusion 
       with 11 residue protease linker

<400>  205

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                245                 250                 255     


Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            260                 265                 270         


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        275                 280                 285             


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly 
305                 310                 315                 320 


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                325                 330                 335     


Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            340                 345                 350         


Pro Leu Gly Val Arg Gly Lys Ala Gly Glu Val Gln Leu Val Glu Ser 
        355                 360                 365             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    370                 375                 380                 


Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln 
385                 390                 395                 400 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                405                 410                 415     


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
            420                 425                 430         


Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        435                 440                 445             


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
    450                 455                 460                 


Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
                485                 490                 495     


Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile 
            500                 505                 510         


Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Trp Leu Gly Trp 
        515                 520                 525             


Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Asp Ile Phe 
    530                 535                 540                 


Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
545                 550                 555                 560 


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
                565                 570                 575     


Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Arg 
            580                 585                 590         


Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
        595                 600                 605             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    610                 615                 620                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
625                 630                 635                 640 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                645                 650                 655     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            660                 665                 670         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        675                 680                 685             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    690                 695                 700                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
705                 710                 


<210>  206
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO261, anti-EpCAM H-TEAC SG3SG4AG4S-linker Fc fusion 
       with 9 residue protease linker

<400>  206

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                245                 250                 255     


Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            260                 265                 270         


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        275                 280                 285             


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly 
305                 310                 315                 320 


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                325                 330                 335     


Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            340                 345                 350         


Pro Leu Gly Val Arg Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
        355                 360                 365             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    370                 375                 380                 


Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
385                 390                 395                 400 


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                405                 410                 415     


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
            420                 425                 430         


Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys 
        435                 440                 445             


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
    450                 455                 460                 


Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Gln 
                485                 490                 495     


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys 
        515                 520                 525             


Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly 
    530                 535                 540                 


Ser Gly Asn Ile His Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu 
545                 550                 555                 560 


Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
                565                 570                 575     


Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp 
            580                 585                 590         


Asp Glu Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        595                 600                 605             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    610                 615                 620                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
625                 630                 635                 640 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                645                 650                 655     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            660                 665                 670         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        675                 680                 685             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    690                 695                 700                 


Lys Lys Val Glu Pro Lys Ser Cys 
705                 710         


<210>  207
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO268, anti-EGFR H-TEAC SG3SG4S-linker Fc fusion

<400>  207

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
225                 230                 235                 240 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                245                 250                 255     


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
            260                 265                 270         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        275                 280                 285             


Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    290                 295                 300                 


Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
305                 310                 315                 320 


Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Ala Val Phe 
                325                 330                 335     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Pro 
            340                 345                 350         


Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly Ser Glu Val Gln Leu 
        355                 360                 365             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    370                 375                 380                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
385                 390                 395                 400 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                405                 410                 415     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
            420                 425                 430         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln 
        435                 440                 445             


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    450                 455                 460                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            500                 505                 510         


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        515                 520                 525             


Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    530                 535                 540                 


Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala 
545                 550                 555                 560 


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                565                 570                 575     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            580                 585                 590         


Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala 
        595                 600                 605             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    610                 615                 620                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
625                 630                 635                 640 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                645                 650                 655     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            660                 665                 670         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        675                 680                 685             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    690                 695                 700                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
705                 710                 715                 720 


Ser Cys His His His His His His 
                725             


<210>  208
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO269, anti-EGFR L-TEAC SG3SG4S-linker Fc Fusion

<400>  208

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Ser 
        275                 280                 285             


Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
    290                 295                 300                 


Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn 
305                 310                 315                 320 


Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Gly Lys 
                325                 330                 335     


Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr Phe Asp Val Trp 
            340                 345                 350         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly Gly Ser Gln Ala Val 
    370                 375                 380                 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
385                 390                 395                 400 


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala 
                405                 410                 415     


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
            420                 425                 430         


Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe Ser Gly Ser 
        435                 440                 445             


Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Glu 
    450                 455                 460                 


Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
465                 470                 475                 480 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr 
        515                 520                 525             


Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr 
545                 550                 555                 560 


Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp 
        595                 600                 605             


Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    610                 615                 620                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
625                 630                 635                 640 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                645                 650                 655     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            660                 665                 670         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        675                 680                 685             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    690                 695                 700                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
705                 710                 715                 720 


Lys Ser Cys His His His His His His 
                725                 


<210>  209
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RO132, anti-EGFR/anti-CD3 bispecific

<400>  209

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    210                 215                 220                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            260                 265                 270         


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        275                 280                 285             


Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    290                 295                 300                 


Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala 
305                 310                 315                 320 


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                325                 330                 335     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala 
        355                 360                 365             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    370                 375                 380                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
385                 390                 395                 400 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                405                 410                 415     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            420                 425                 430         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        435                 440                 445             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    450                 455                 460                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
465                 470                 475                 480 


Ser Cys His His His His His His 
                485             


<210>  210
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human serum albumin fusion of SP34 VH TEAC, MMP2 
       cleavage site, anti-EGFR Fab heavy chain

<400>  210

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly 
        595                 600                 605             


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
    610                 615                 620                 


Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr 
625                 630                 635                 640 


Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
                645                 650                 655     


Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala 
            660                 665                 670         


Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr 
        675                 680                 685             


Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr 
    690                 695                 700                 


Ser Asn Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
705                 710                 715                 720 


Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly Gly 
                725                 730                 735     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            740                 745                 750         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
        755                 760                 765             


Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    770                 775                 780                 


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
785                 790                 795                 800 


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                805                 810                 815     


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
            820                 825                 830         


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser 
        835                 840                 845             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    850                 855                 860                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
865                 870                 875                 880 


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
                885                 890                 895     


Ala Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln 
            900                 905                 910         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser 
        915                 920                 925             


Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
    930                 935                 940                 


Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
945                 950                 955                 960 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly 
                965                 970                 975     


Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            980                 985                 990         


Ser Ala Ser Thr Lys Gly Pro Ser  Val Phe Pro Leu Ala  Pro Ser Ser 
        995                 1000                 1005             


Lys Ser  Thr Ser Gly Gly Thr  Ala Ala Leu Gly Cys  Leu Val Lys 
    1010                 1015                 1020             


Asp Tyr  Phe Pro Glu Pro Val  Thr Val Ser Trp Asn  Ser Gly Ala 
    1025                 1030                 1035             


Leu Thr  Ser Gly Val His Thr  Phe Pro Ala Val Leu  Gln Ser Ser 
    1040                 1045                 1050             


Gly Leu  Tyr Ser Leu Ser Ser  Val Val Thr Val Pro  Ser Ser Ser 
    1055                 1060                 1065             


Leu Gly  Thr Gln Thr Tyr Ile  Cys Asn Val Asn His  Lys Pro Ser 
    1070                 1075                 1080             


Asn Thr  Lys Val Asp Lys Lys  Val Glu Pro Lys Ser  Cys His His 
    1085                 1090                 1095             


His His  His His 
    1100         


<210>  211
<211>  1103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human serum albumin fusion of SP34 VL TEAC, MMP2 
       cleavage site, anti-EGFR Fab heavy chain

<400>  211

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    610                 615                 620                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
625                 630                 635                 640 


Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                645                 650                 655     


Trp Val Ala Arg Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
            660                 665                 670         


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
        675                 680                 685             


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
    690                 695                 700                 


Tyr Cys Val Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val 
705                 710                 715                 720 


Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                725                 730                 735     


Gly Gly Gly Gly Ser Gly Pro Leu Gly Val Arg Gly Lys Ala Gly Gly 
            740                 745                 750         


Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
        755                 760                 765             


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
    770                 775                 780                 


Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
785                 790                 795                 800 


Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro 
                805                 810                 815     


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile 
            820                 825                 830         


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp 
        835                 840                 845             


Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    850                 855                 860                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
865                 870                 875                 880 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
                885                 890                 895     


Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg 
            900                 905                 910         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn 
        915                 920                 925             


Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
    930                 935                 940                 


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
945                 950                 955                 960 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly 
                965                 970                 975     


Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val 
            980                 985                 990         


Ser Ser Ala Ser Thr Lys Gly Pro  Ser Val Phe Pro Leu  Ala Pro Ser 
        995                 1000                 1005             


Ser Lys  Ser Thr Ser Gly Gly  Thr Ala Ala Leu Gly  Cys Leu Val 
    1010                 1015                 1020             


Lys Asp  Tyr Phe Pro Glu Pro  Val Thr Val Ser Trp  Asn Ser Gly 
    1025                 1030                 1035             


Ala Leu  Thr Ser Gly Val His  Thr Phe Pro Ala Val  Leu Gln Ser 
    1040                 1045                 1050             


Ser Gly  Leu Tyr Ser Leu Ser  Ser Val Val Thr Val  Pro Ser Ser 
    1055                 1060                 1065             


Ser Leu  Gly Thr Gln Thr Tyr  Ile Cys Asn Val Asn  His Lys Pro 
    1070                 1075                 1080             


Ser Asn  Thr Lys Val Asp Lys  Lys Val Glu Pro Lys  Ser Cys His 
    1085                 1090                 1095             


His His  His His His 
    1100             


<210>  212
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD8-CD3 VL ATTAC component   (Anti-CD8 VHH 6xG4S 
       connector  anti-CD3e VL (20G6) - Enterokinase cleavage sequence  
       Ig VH domain  2xG4S connector  IgG4 CH domains  EPEA tag)  (CD8 
       targeting VHH domain based upon WO_2017_134306 SEQ ID NO: 21)

<400>  212

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Val Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Leu Tyr Thr Cys Val Gln Ser Ile Val Trp Pro Ala 
            100                 105                 110         


Arg Pro Tyr Tyr Asp Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                165                 170                 175     


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
            180                 185                 190         


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly 
        195                 200                 205             


Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
    210                 215                 220                 


Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
                245                 250                 255     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln 
            260                 265                 270         


Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu 
        275                 280                 285             


Gly Thr Ser Thr Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln Val Gln Leu Val Gln Ser 
                325                 330                 335     


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
            340                 345                 350         


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln 
        355                 360                 365             


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn 
    370                 375                 380                 


Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr 
385                 390                 395                 400 


Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
                405                 410                 415     


Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu 
            420                 425                 430         


Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        435                 440                 445             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro 
    450                 455                 460                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
465                 470                 475                 480 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                485                 490                 495     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            500                 505                 510         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        515                 520                 525             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    530                 535                 540                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
545                 550                 555                 560 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                565                 570                 575     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            580                 585                 590         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        595                 600                 605             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    610                 615                 620                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
625                 630                 635                 640 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                645                 650                 655     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            660                 665                 670         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser 
        675                 680                 685             


Glu Pro Glu Ala 
    690         


<210>  213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  213

Tyr Leu Gly Arg Ser Tyr Lys Val 
1               5               


<210>  214
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  214

Met Gln Leu Gly Arg Xaa 
1               5       


<210>  215
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  215

Ser Leu Gly Arg Lys Ile Gln Ile 
1               5               


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  216

Gly Leu Ala Arg Ser Asn Leu Asp Glu 
1               5                   


