                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  NOVEL AAV CAPSIDS AND COMPOSITIONS CONTAINING SAME

<130>  19-8901PCT3

<150>  US 62/924,095
<151>  2019-10-21

<150>  US 62/913,314
<151>  2019-10-10

<150>  US 62/840,184
<151>  2019-04-29

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2202
<212>  DNA
<213>  adeno-associated virus rh.92


<220>
<221>  CDS
<222>  (1)..(2202)

<400>  1
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc ccc aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aag gcc aac cag cag aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gag gcg gac gcc gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag agg gta ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctg ggc ctg gtt gaa gaa ggt gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg tta gag tca cca caa gag cca gac tcc tcc tcg gga atc ggc aaa        480
Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys           
145                 150                 155                 160           

aaa ggc aaa caa cca gcc aaa aag aga ctc aac ttt gaa gag gac act        528
Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr           
                165                 170                 175               

gga gcc gga gac gga ccc cct gaa gga tca gat acc agc gcc atg tct        576
Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser           
            180                 185                 190                   

tca gac att gaa atg cgt gca gca ccg ggc gga aat gct gtc gat gcg        624
Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala           
        195                 200                 205                       

gga caa ggt tcc gat gga gtg ggt aat gcc tcg ggt gat tgg cat tgc        672
Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys           
    210                 215                 220                           

gat tcc acc tgg tct gag ggc aag gtc aca aca acc tcg acc aga acc        720
Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr           
225                 230                 235                 240           

tgg gtc ttg ccc acc tac aac aac cac ctg tac ctg cgg ctc gga aca        768
Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr           
                245                 250                 255               

aca tca aac agc aac acc tac aac gga ttc tcc acc ccc tgg gga tac        816
Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr           
            260                 265                 270                   

ttt gac ttt aac aga ttc cac tgt cac ttc tca cca cgt gac tgg caa        864
Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln           
        275                 280                 285                       

aga ctc atc aac aac aac tgg gga cta cga cca aaa gcc atg cgc gtt        912
Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val           
    290                 295                 300                           

aaa atc ttc aat atc caa gtt aag gag gtc aca acg tcg aac ggc gag        960
Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu           
305                 310                 315                 320           

act acg gtc gct aat aac ctt acc agc acg gtt cag ata ttt gcg gac       1008
Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp           
                325                 330                 335               

tcg tcg tat gag ctc ccg tac gtg atg gac gct gga caa gag ggg agc       1056
Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser           
            340                 345                 350                   

ctg cct cct ttc ccc aat gac gtc ttt atg gtg cct caa tat ggc tac       1104
Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr           
        355                 360                 365                       

tgt ggc atc gtg act ggc gag aat cag aac cag acg gac aga aat gcc       1152
Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala           
    370                 375                 380                           

ttc tac tgc ctg gag tat ttt cct tca caa atg ttg aga act ggc aac       1200
Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn           
385                 390                 395                 400           

aac ttt gaa atg gct tac aac ttt gag aag gtg ccg ttc cac tca atg       1248
Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met           
                405                 410                 415               

tat gct cac agc cag agc ctg gac aga ctg atg aat ccc ctc ctg gac       1296
Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp           
            420                 425                 430                   

cag tac ctg tgg cac tta cag tcg act acc tct gga ggg act ctg aat       1344
Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn           
        435                 440                 445                       

caa ggc aat gca gca acc aca ttt gga aaa atc agg agt gga gac ttt       1392
Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe           
    450                 455                 460                           

gcc ttt tac aga aag aac tgg ctg cct ggg cct tgt gtt aag cag cag       1440
Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln           
465                 470                 475                 480           

aga ttc tca aag act gcc agt caa aac tac aag att cct gcc agc ggg       1488
Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly           
                485                 490                 495               

ggc gac gct ctg tta aag tat gac acc cac tat acc tta aac aac cgg       1536
Gly Asp Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg           
            500                 505                 510                   

tgg agc aac atc gcg ccc gga cct cca atg gcc aca gcc gga cct tcg       1584
Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser           
        515                 520                 525                       

gat ggg gac ttc agt aac gcc cag ctt ata ttc cct gga cca tct gtt       1632
Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val           
    530                 535                 540                           

acc gga aat aca aca act tca gcc aac aat ctg ttg ttt aca tca gaa       1680
Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu           
545                 550                 555                 560           

gaa gaa att gct gcc acc aac cca aga gac acg gac atg ttt ggc cag       1728
Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln           
                565                 570                 575               

att gct gac aat aat cag aat gct aca act gct ccc ata acc ggc aac       1776
Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn           
            580                 585                 590                   

gtg act gct atg gga gtg ctg cct ggc atg gtg tgg caa aac aga gac       1824
Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp           
        595                 600                 605                       

att tac tac caa ggg cca att tgg gcc aag atc cca cac gcg gac gga       1872
Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly           
    610                 615                 620                           

cat ttt cat cct tca ccg ctg att ggt ggg ttt gga ctg aaa cac ccg       1920
His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro           
625                 630                 635                 640           

cct ccc cag ata ttc atc aag aac act ccc gta cct gcc aat cct gcg       1968
Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala           
                645                 650                 655               

aca acc ttc act gca gcc aga gtg gac tct ttc att aca caa tac agc       2016
Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser           
            660                 665                 670                   

acc ggc cag gtc gct gtt cag att gaa tgg gaa att gaa aag gaa cgc       2064
Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg           
        675                 680                 685                       

tcc aaa cgc tgg aat cct gaa gtg cag ttt act tca aac tat ggg aac       2112
Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn           
    690                 695                 700                           

cag tct tct atg ttg tgg gct cct gat aca act ggg aag tat aca gag       2160
Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu           
705                 710                 715                 720           

ccg cgg gtt att ggc tct cgt tat ttg act aat cat ttg taa               2202
Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu                       
                725                 730                                   


<210>  2
<211>  733
<212>  PRT
<213>  adeno-associated virus rh.92

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asp Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210>  3
<211>  2187
<212>  DNA
<213>  adeno-associated virus rh.93


<220>
<221>  CDS
<222>  (1)..(2187)

<400>  3
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctg cag gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aaa acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccc gta gac tct cca gac tcc tcc acg ggc atc ggc aag aaa ggc cag        480
Pro Val Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln           
145                 150                 155                 160           

cag ccc gcg aaa aag aag ctc aac ttt ggg cag act ggc gac tca gag        528
Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu           
                165                 170                 175               

tca gtc ccc gac cct caa cct ctc tca gaa cct cca gca gcg ccc act        576
Ser Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Ala Pro Thr           
            180                 185                 190                   

agt gtg gga tct ggt aca gtg gct gca ggc agt ggc gca cca atg gca        624
Ser Val Gly Ser Gly Thr Val Ala Ala Gly Ser Gly Ala Pro Met Ala           
        195                 200                 205                       

gac aat aac gaa ggt gcc gac gga gtg ggt aat gcc tca gga aat tgg        672
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp           
    210                 215                 220                           

cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc acc acc agc acc        720
His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
225                 230                 235                 240           

cga acc tgg gcc ctg ccc acc tac aac aac cac ctc tac aag caa atc        768
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                245                 250                 255               

tcc agt cag agc ggg gct acc aac gac aac cac ttc ttt ggc tac agc        816
Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser           
            260                 265                 270                   

acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac ttc tca        864
Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser           
        275                 280                 285                       

cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc cgg ccc        912
Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro           
    290                 295                 300                           

aag aag ctg cgg ttc aag ctc ttc aac atc caa gtc aaa gag gtt acg        960
Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr           
305                 310                 315                 320           

acg aac gac ggc gtc aca acc atc gct aat aac ctt acc agc acg att       1008
Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile           
                325                 330                 335               

cag gtt ttc tcg gac tcg gag tac cag ctg ccg tac gtc ctc ggc tct       1056
Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser           
            340                 345                 350                   

gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg gac gtc ttc atg att       1104
Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile           
        355                 360                 365                       

cct cag tac ggc tac ctg acg ctc aac aac ggt agt cag tct gtg ggt       1152
Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly           
    370                 375                 380                           

cgt tct tcc ttc tac tgc ctg gaa tat ttc ccc tct caa atg ctg aga       1200
Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg           
385                 390                 395                 400           

acg ggc aac aac ttt gaa ttc agt tac acc ttc gag gat gtg cct ttc       1248
Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe           
                405                 410                 415               

cac agc agc tac gcg cat agc cag agc ctg gac cgg ctg atg aat cct       1296
His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro           
            420                 425                 430                   

ctt atc gac cag tat ctg tac tac ctg gcc cgg acc cag agc acc acg       1344
Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr           
        435                 440                 445                       

ggt tcc acc aga gag ctg cag ttt cat cag gct ggg ccc aac act atg       1392
Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met           
    450                 455                 460                           

gcc gag caa tca aag aac tgg tta cct ggt cct tgc ttc cgg caa caa       1440
Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln           
465                 470                 475                 480           

cgc gtt tcc aag gtg ctg gat cag aac gcc aac agc aac ttt gcc tgg       1488
Arg Val Ser Lys Val Leu Asp Gln Asn Ala Asn Ser Asn Phe Ala Trp           
                485                 490                 495               

act gct gcc act aaa tat cac ttg aat ggg cgt aac tct ctg acc aat       1536
Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn           
            500                 505                 510                   

ccg gga gtt ccc atg gca aca cac aag gac gac gag gac agg ttc ttt       1584
Pro Gly Val Pro Met Ala Thr His Lys Asp Asp Glu Asp Arg Phe Phe           
        515                 520                 525                       

ccc att aac ggg gtg ctg gtt ttt ggc aag acc gga gcc gcc aac aaa       1632
Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys           
    530                 535                 540                           

aca acg ctg gaa aat gtt ctg atg aca aac gaa gaa gaa atc aaa act       1680
Thr Thr Leu Glu Asn Val Leu Met Thr Asn Glu Glu Glu Ile Lys Thr           
545                 550                 555                 560           

acc aac ccg gtg gct aca gaa gaa tat ggc gtg gtt tcc agc aat ttg       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu           
                565                 570                 575               

cag gct ggg act aca aac cca cag aca ctg act gtt aac aac cag ggg       1776
Gln Ala Gly Thr Thr Asn Pro Gln Thr Leu Thr Val Asn Asn Gln Gly           
            580                 585                 590                   

gcc tta cct ggc atg gtg tgg cag aac agg gac gtg tac ctg caa ggt       1824
Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gcc aaa att cct cac acg gac ggc aac ttt cac ccg tct       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser           
    610                 615                 620                           

cct ttg atg ggt gga ttt gga ctt aaa cac ccg cct cct cag atc cta       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

att aaa aac acg cct gtt cct gcc aat cct ccg gag gtg ttt act cct       1968
Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro           
                645                 650                 655               

gcc aag ttt gct tcg ttc atc acg cag tac agc acc ggt cag gtc agc       2016
Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aaa gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

cca gag att cag tac act tcc aat ttt gat aaa tct aat aat gtg gac       2112
Pro Glu Ile Gln Tyr Thr Ser Asn Phe Asp Lys Ser Asn Asn Val Asp           
    690                 695                 700                           

ttt gct gtt aac aat gaa ggt gtt tac tct gag cct cgc ccc att ggc       2160
Phe Ala Val Asn Asn Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly           
705                 710                 715                 720           

act cgc tac ctc acc cgt aac ctg taa                                   2187
Thr Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  4
<211>  728
<212>  PRT
<213>  adeno-associated virus rh.93

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Ala Pro Thr 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Val Ala Ala Gly Ser Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln 
465                 470                 475                 480 


Arg Val Ser Lys Val Leu Asp Gln Asn Ala Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Pro Met Ala Thr His Lys Asp Asp Glu Asp Arg Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Asn Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ala Gly Thr Thr Asn Pro Gln Thr Leu Thr Val Asn Asn Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Phe Asp Lys Ser Asn Asn Val Asp 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  5
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic hybrid of AAVrh.91 and AAVrh.93


<220>
<221>  CDS
<222>  (1)..(2202)

<400>  5
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa gca gct aag acg gct cct gga aag aaa cgt        432
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg ccc caa gaa cca gac tcc tcc tcg ggc att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aaa tca ggc cag cag ccc gcc aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gaa acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctt cct acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agc gct tca acg ggg gcc agt aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aag ctg cgg ttc aag ctc ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aaa gag gtt acg acg aac gac ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg att cag gtt ttc tcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggc tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg att cct cag tac ggc tac ctg acg ctc aac aac ggt       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cag tct gtg ggt cgt tct tcc ttc tac tgc ctg gaa tat ttc ccc       1200
Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tct caa atg ctg aga acg ggc aac aac ttt gaa ttc agt tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe           
                405                 410                 415               

gag gat gtg cct ttc cac agc agc tac gcg cat agc cag agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cgg ctg atg aat cct ctt atc gac cag tat ctg tac tac ctg gcc cgg       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg           
        435                 440                 445                       

acc cag agc acc acg ggt tcc acc aga gag ctg cag ttt cat cag gct       1392
Thr Gln Ser Thr Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala           
    450                 455                 460                           

ggg ccc aac act atg gcc gag caa tca aag aac tgg tta cct ggt cct       1440
Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro           
465                 470                 475                 480           

tgc ttc cgg caa caa cgc gtt tcc aag gtg ctg gat cag aac gcc aac       1488
Cys Phe Arg Gln Gln Arg Val Ser Lys Val Leu Asp Gln Asn Ala Asn           
                485                 490                 495               

agc aac ttt gcc tgg act gct gcc act aaa tat cac ttg aat ggg cgt       1536
Ser Asn Phe Ala Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg           
            500                 505                 510                   

aac tct ctg acc aat ccg gga gtt ccc atg gca aca cac aag gac gac       1584
Asn Ser Leu Thr Asn Pro Gly Val Pro Met Ala Thr His Lys Asp Asp           
        515                 520                 525                       

gag gac agg ttc ttt ccc att aac ggg gtg ctg gtt ttt ggc aag acc       1632
Glu Asp Arg Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr           
    530                 535                 540                           

gga gcc gcc aac aaa aca acg ctg gaa aat gtt ctg atg aca aac gaa       1680
Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr Asn Glu           
545                 550                 555                 560           

gaa gaa atc aaa act acc aac ccg gtg gct aca gaa gaa tat ggc gtg       1728
Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val           
                565                 570                 575               

gtt tcc agc aat ttg cag gct ggg act aca aac cca cag aca ctg act       1776
Val Ser Ser Asn Leu Gln Ala Gly Thr Thr Asn Pro Gln Thr Leu Thr           
            580                 585                 590                   

gtt aac aac cag ggg gcc tta cct ggc atg gtg tgg cag aac agg gac       1824
Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp           
        595                 600                 605                       

gtg tac ctg caa ggt ccc atc tgg gcc aaa att cct cac acg gac ggc       1872
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly           
    610                 615                 620                           

aac ttt cac ccg tct cct ttg atg ggt gga ttt gga ctt aaa cac ccg       1920
Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro           
625                 630                 635                 640           

cct cct cag atc cta att aaa aac acg cct gtt cct gcc aat cct ccg       1968
Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro           
                645                 650                 655               

gag gtg ttt act cct gcc aag ttt gct tcg ttc atc acg cag tac agc       2016
Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser           
            660                 665                 670                   

acc ggt cag gtc agc gtg gaa atc gag tgg gag ctg cag aaa gaa aac       2064
Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn           
        675                 680                 685                       

agc aag cgc tgg aac cca gag att cag tac act tcc aat ttt gat aaa       2112
Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Phe Asp Lys           
    690                 695                 700                           

tct aat aat gtg gac ttt gct gtt aac aat gaa ggt gtt tac tct gag       2160
Ser Asn Asn Val Asp Phe Ala Val Asn Asn Glu Gly Val Tyr Ser Glu           
705                 710                 715                 720           

cct cgc ccc att ggc act cgc tac ctc acc cgt aac ctg taa               2202
Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu                       
                725                 730                                   


<210>  6
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        435                 440                 445             


Thr Gln Ser Thr Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala 
    450                 455                 460                 


Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Phe Arg Gln Gln Arg Val Ser Lys Val Leu Asp Gln Asn Ala Asn 
                485                 490                 495     


Ser Asn Phe Ala Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Thr Asn Pro Gly Val Pro Met Ala Thr His Lys Asp Asp 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr 
    530                 535                 540                 


Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr Asn Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val 
                565                 570                 575     


Val Ser Ser Asn Leu Gln Ala Gly Thr Thr Asn Pro Gln Thr Leu Thr 
            580                 585                 590         


Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro 
                645                 650                 655     


Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Phe Asp Lys 
    690                 695                 700                 


Ser Asn Asn Val Asp Phe Ala Val Asn Asn Glu Gly Val Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210>  7
<211>  2214
<212>  DNA
<213>  adeno-associated virus 7


<220>
<221>  CDS
<222>  (1)..(2214)

<400>  7
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac aac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tca ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gca aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg           
    130                 135                 140                           

ccg gta gag ccg tca cct cag cgt tcc ccc gac tcc tcc acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc cag cag ccc gcc aga aag aga ctc aat ttc ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro           
            180                 185                 190                   

cca gca gcg ccc tct agt gtg gga tct ggt aca gtg gct gca ggc ggt        624
Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly           
        195                 200                 205                       

ggc gca cca atg gca gac aat aac gaa ggt gcc gac gga gtg ggt aat        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn           
    210                 215                 220                           

gcc tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

att acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc agt gaa act gca ggt agt acc aac gac aac        816
Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn           
            260                 265                 270                   

acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttt aac aga        864
Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg ccc aag aag ctg cgg ttc aag ctc ttc aac atc        960
Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aag gag gtc acg acg aat gac ggc gtt acg acc atc gct aat       1008
Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg att cag gta ttc tcg gac tcg gaa tac cag ctg       1056
Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtc ctc ggc tct gcg cac cag ggc tgc ctg cct ccg ttc ccg       1104
Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtc ttc atg att cct cag tac ggc tac ctg act ctc aac aat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn           
    370                 375                 380                           

ggc agt cag tct gtg gga cgt tcc tcc ttc tac tgc ctg gag tac ttc       1200
Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccc tct cag atg ctg aga acg ggc aac aac ttt gag ttc agc tac agc       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser           
                405                 410                 415               

ttc gag gac gtg cct ttc cac agc agc tac gca cac agc cag agc ctg       1296
Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cgg ctg atg aat ccc ctc atc gac cag tac ttg tac tac ctg gcc       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala           
        435                 440                 445                       

aga aca cag agt aac cca gga ggc aca gct ggc aat cgg gaa ctg cag       1392
Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln           
    450                 455                 460                           

ttt tac cag ggc ggg cct tca act atg gcc gaa caa gcc aag aat tgg       1440
Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp           
465                 470                 475                 480           

tta cct gga cct tgc ttc cgg caa caa aga gtc tcc aaa acg ctg gat       1488
Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp           
                485                 490                 495               

caa aac aac aac agc aac ttt gct tgg act ggt gcc acc aaa tat cac       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His           
            500                 505                 510                   

ctg aac ggc aga aac tcg ttg gtt aat ccc ggc gtc gcc atg gca act       1584
Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr           
        515                 520                 525                       

cac aag gac gac gag gac cgc ttt ttc cca tcc agc gga gtc ctg att       1632
His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile           
    530                 535                 540                           

ttt gga aaa act gga gca act aac aaa act aca ttg gaa aat gtg tta       1680
Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu           
545                 550                 555                 560           

atg aca aat gaa gaa gaa att cgt cct act aat cct gta gcc acg gaa       1728
Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu           
                565                 570                 575               

gaa tac ggg ata gtc agc agc aac tta caa gcg gct aat act gca gcc       1776
Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala           
            580                 585                 590                   

cag aca caa gtt gtc aac aac cag gga gcc tta cct ggc atg gtc tgg       1824
Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp           
        595                 600                 605                       

cag aac cgg gac gtg tac ctg cag ggt ccc atc tgg gcc aag att cct       1872
Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro           
    610                 615                 620                           

cac acg gat ggc aac ttt cac ccg tct cct ttg atg ggc ggc ttt gga       1920
His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly           
625                 630                 635                 640           

ctt aaa cat ccg cct cct cag atc ctg atc aag aac act ccc gtt ccc       1968
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro           
                645                 650                 655               

gct aat cct ccg gag gtg ttt act cct gcc aag ttt gct tcg ttc atc       2016
Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile           
            660                 665                 670                   

aca cag tac agc acc gga caa gtc agc gtg gaa atc gag tgg gag ctg       2064
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu           
        675                 680                 685                       

cag aag gaa aac agc aag cgc tgg aac ccg gag att cag tac acc tcc       2112
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser           
    690                 695                 700                           

aac ttt gaa aag cag act ggt gtg gac ttt gcc gtt gac agc cag ggt       2160
Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly           
705                 710                 715                 720           

gtt tac tct gag cct cgc cct att ggc act cgt tac ctc acc cgt aat       2208
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn           
                725                 730                 735               

ctg taa                                                               2214
Leu                                                                       
                                                                          


<210>  8
<211>  737
<212>  PRT
<213>  adeno-associated virus 7

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  9
gctgcgtcaa ctggaccaat gagaac                                            26


<210>  10
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  10
cgcagagacc aaagttcaac tgaaacga                                          28


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  11
ggcgaacagc ggacaccgat atgaa                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  12
ggctctcgtc gcgtgagaat gagaa                                             25


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  13
agtgaattct accagtgcca ta                                                22


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  14
agtgtgagtt ctaccattgc caaa                                              24


