                         SEQUENCE LISTING

<110>  INCYTE CORPORATION
 
<120>  TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS

<130>  20443-0606WO1

<150>  US 62/841,669
<151>  2019-05-01

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  2
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Thr Met 
1               5                   10                  15      


Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 
        35                  40                  45              


Ile Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 
    50                  55                  60                  


Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys 
65                  70                  75                  80  


Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro Arg Ile 
                85                  90                  95      


Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn 
            100                 105                 110         


Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Thr Tyr Leu 
        115                 120                 125             


Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met 
    130                 135                 140                 


Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys 
145                 150                 155                 160 


Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 
                165                 170                 175     


Met Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 
            180                 185                 190         


Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro 
        195                 200                 205             


Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly Asp 
    210                 215                 220                 


Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg 
225                 230                 235                 240 


Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Met Gln Val 
                245                 250                 255     


Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro Gln 
            260                 265                 270         


Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 
        275                 280                 285             


Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 
    290                 295                 300                 


Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 
305                 310                 315                 320 


Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala Met 
                325                 330                 335     


Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe Arg Gly Val 
            340                 345                 350         


Ala Asp Glu Asp Ala His Asn Ile Gln Thr His Arg Asp Ser Leu Asp 
        355                 360                 365             


Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln Asn 
    370                 375                 380                 


Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Thr Pro Pro Gln Ser Gly 
385                 390                 395                 400 


Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
                405                 410 


<210>  3
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
        35                  40                  45              


Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
    50                  55                  60                  


Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
65                  70                  75                  80  


Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                85                  90                  95      


Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
            100                 105                 110         


Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
        115                 120                 125             


His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
    130                 135                 140                 


Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
145                 150                 155                 160 


Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                165                 170                 175     


Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
            180                 185                 190         


Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
        195                 200                 205             


Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
    210                 215                 220                 


Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
225                 230                 235                 240 


Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                245                 250                 255     


Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
            260                 265                 270         


Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
        275                 280                 285             


Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
    290                 295                 300                 


Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
305                 310                 315                 320 


Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                325                 330                 335     


Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
            340                 345                 350         


Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
        355                 360                 365             


Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
    370                 375                 380                 


Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
385                 390                 395                 400 


Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                405                 410                 415     


Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
            420                 425                 430         


Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
        435                 440                 445             


Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
    450                 455                 460                 


Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
465                 470                 475                 480 


Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                485                 490                 495     


Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
            500                 505                 510         


Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
        515                 520                 525             


Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
    530                 535                 540                 


Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
545                 550                 555                 560 


Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                565                 570                 575     


Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
            580                 585                 590         


Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
        595                 600                 605             


Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
    610                 615                 620                 


Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                645                 650                 655     


Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
            660                 665                 670         


His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
        675                 680                 685             


Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
    690                 695                 700                 


Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
705                 710                 715                 720 


Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                725                 730                 735     


Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
            740                 745                 750         


Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
        755                 760                 765             


Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
    770                 775                 780                 


Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
785                 790                 795                 800 


Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                805                 810                 815     


Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
            820                 825                 830         


Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
        835                 840                 845             


Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
    850                 855                 860                 


Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
865                 870                 875                 880 


Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                885                 890                 895     


Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
            900                 905                 910         


Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
        915                 920                 925             


<210>  4
<211>  1306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
cctcgaattc agctgcatgg agaacttcca aaaggtggaa aagatcggag agggcacgta       60

cggagttgtg tacaaagcca gaaacaagtt gacgggagag gtggtggcgc ttaagaaaat      120

ccgcctggac actgagactg agggtgtgcc cagtactgcc atccgagaga tctctctgct      180

taaggagctt aaccatccta atattgtcaa gctgctggat gtcattcaca cagaaaataa      240

actctacctg gtttttgaat ttctgcacca agatctcaag aaattcatgg atgcctctgc      300

tctcactggc attcctcttc ccctcatcaa gagctatctg ttccagctgc tccagggcct      360

agctttctgc cattctcatc gggtcctcca ccgagacctt aaacctcaga atctgcttat      420

taacacagag ggggccatca agctagcaga ctttggacta gccagagctt ttggagtacc      480

tgttcgtact tacacccatg aagtggtgac cctgtggtac cgagctcctg aaatcctcct      540

gggctgcaaa tattattcca cagctgtgga catctggagc ctgggctgca tctttgctga      600

gatggtgact cgccgggccc tattccctgg agattctgag attgaccagc tctttcggat      660

ctttcggact ctggggaccc cagatgaggt ggtgtggcca ggagttactt ctatgcctga      720

ttacaagcca agtttcccca agtgggcccg gcaagatttt agtaaagttg tacctcccct      780

ggatgaagat ggacggagct tgttatcgca aatgctgcac tacgacccta acaagcggat      840

ttcggccaag gcagccctgg ctcacccttt cttccaggat gtgaccaagc cagtacccca      900

tcttcgactc ggagtgcagg tggaaaccat ctccccagga gacgggcgca ccttccccaa      960

gcgcggccag acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaagttga     1020

ttcctcccgg gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg     1080

aggctgggaa gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc     1140

tccagattat gcctatggtg ccactgggca cccaggcatc atcccaccac atgccactct     1200

cgtcttcgat gtggagcttc taaaactgga aggataccct tacgacgttc ctgattacgc     1260

ttacccttac gacgttcctg attacgctgg atcctaattc gaaagc                    1306


<210>  5
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
gaattc                                                                   6


<210>  6
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
ggatcc                                                                   6


<210>  7
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
ttcgaa                                                                   6


<210>  8
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  8
aagcagagat ctctcgga                                                     18


