                         SEQUENCE LISTING

<110>  AMLo Biosciences LTD
 
<120>  Biomarkers for Disease Progression in Squamous Cell Carcinoma

<130>  P031503WO

<150>  GB1911215.0
<151>  2019-08-06

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of the anti-Ambra-1 antibody

AbD33473

<400>  1

Ser Tyr Trp Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of the anti-Ambra-1 antibody AbD33473

<400>  2

Thr Ile Phe Pro Ser Arg Ser Tyr Thr Thr Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of the anti-Ambra-1 antibody AbD33473

<400>  3

Asp Thr Pro Ser Thr Ala Leu Lys Ser Pro Phe Asp Tyr 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of the anti-Ambra-1 antibody AbD33473

<400>  4

Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn Tyr Val Tyr 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of the anti-Ambra-1 antibody AbD33473

<400>  5

Glu Asn Asn Lys Arg Pro Ser 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of the anti-Ambra-1 antibody AbD33473

<400>  6

Ser Ser Trp Asp Ser His Ser Asn Ser Tyr Val 
1               5                   10      


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR1 of the anti-Ambra-1 antibody AbD33473

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser 
            20                  25                  30  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR2 of the anti-Ambra-1 antibody AbD33473

<400>  8

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR3 of the anti-Ambra-1 antibody AbD33473

<400>  9

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR4 of the anti-Ambra-1 antibody AbD33473

<400>  10

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR1 of the anti-Ambra-1 antibody AbD33473

<400>  11

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR2 of the anti-Ambra-1 antibody AbD33473

<400>  12

Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR3 of the anti-Ambra-1 antibody AbD33473

<400>  13

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR4 of the anti-Ambra-1 antibody AbD33473

<400>  14

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
1               5                   10          


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of the anti-Ambra-1 antibody AbD33473

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Phe Pro Ser Arg Ser Tyr Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Ser Thr Ala Leu Lys Ser Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of the anti-Ambra-1 antibody AbD33473

<400>  16

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser His Ser 
                85                  90                  95      


Asn Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  17
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fd chain (VH domain and constant domain) of the Fab region of the
       anti-Ambra-1 antibody AbD33473

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Phe Pro Ser Arg Ser Tyr Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Ser Thr Ala Leu Lys Ser Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


<210>  18
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain (VL domain and constant domain) of the Fab region of 
       the anti-Ambra-1 antibody AbD33473

<400>  18

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser His Ser 
                85                  90                  95      


Asn Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Ala 
    210                 215 


<210>  19
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fd chain of the Fab region and tags (alkaline phosphatase 
       dimerization domain sequence (AP), FLAG tag (DYKDDDDK) and His6 
       tag of the anti-Ambra-1 antibody AbD33473

<400>  19
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gctccggata tagcttctct tcttactgga tccattgggt gcgccagatg      120

ccgggcaaag gtctcgagtg gatgggcact atcttcccgt ctcgtagcta caccacttat      180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat      240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgacact      300

ccgtctactg ctctgaaatc tccgttcgat tactggggcc aaggcaccct ggtgactgtt      360

agctcagcgt cgaccaaagg cccgagcgtg tttccgctgg ccccgagcag caaaagcacc      420

agcggcggca ccgccgcact gggctgcctg gtgaaagatt atttcccgga accagtgacc      480

gtgagctgga acagcggtgc cctgaccagc ggcgtgcata cctttccggc ggtgctgcaa      540

agcagcggcc tgtatagcct gagcagcgtt gtgaccgtgc cgagcagcag cctgggcacc      600

cagacctata tttgcaacgt caaccataaa ccgagcaaca ccaaagtcga taaaaaagtc      660

gaaccgaaaa gcgaattcaa ggctgaaatg cctgttctgg aaaaccgggc tgctcagggc      720

gatattacta cacccggcgg tgctcgccgt ttaacgggtg atcagactgc cgctctgcgt      780

gattctctta gcgataaacc tgcaaaaaat attattttgc tgattggcga tgggatgggg      840

gactcggaaa ttactgccgc acgtaattat gccgaaggtg cgggcggctt ttttaaaggt      900

atagatgcct taccgcttac cgggcaatac actcactatg cgctgaatag aaaaaccggc      960

aaaccggact acgtcaccag ctcggctgca tcagcaaccg cctggtcaac cggtgtcaaa     1020

acctataacg gcgcgctggg cgtcgatatt cacgaaaaag atcacccaac gattctggaa     1080

atggcaaaag ccgcaggtct ggcgaccggt aacgtttcta ccgcagagtt gcaggatgcc     1140

acgcccgctg cgctggtggc acatgtgacc tcgcgcaaat gctacggtcc gagcgcgacc     1200

agtgaaaaat gtccgggtaa cgctctggaa aaaggcggaa aaggatcgat taccgaacag     1260

ctgcttaacg ctcgtgccga cgttacgctt ggcggcggcg caaaaacctt tgctgaaacg     1320

gcaaccgctg gtgaatggca gggaaaaacg ctgcgtgaac aggcacaggc gcgtggttat     1380

cagttggtga gcgatgctgc ctcactgaac tcggtgacgg aagcgaatca gcaaaaaccc     1440

ctgcttggcc tgtttgctga cggcaatatg ccagtgcgct ggctaggacc gaaagcaacg     1500

taccatggca atatcgataa gcccgcagtc acctgtacgc caaatccgca acgtaatgac     1560

agtgtaccaa ccctggcgca gatgaccgac aaagccattg aattgttgag taaaaatgag     1620

aaaggctttt tcctgcaagt tgaaggtgcg tcaatcgata aacaggatca tgctgcgaat     1680

ccttgtgggc aaattggcga gacggtcgat ctcgatgaag ccgtacaacg ggcgctggag     1740

ttcgctaaaa aggagggtaa cacgctggtc atagtcaccg ctgatcacgc ccacgccagc     1800

cagattgttg cgccggatac caaagctccg ggcctcaccc aggcgctaaa taccaaagat     1860

ggcgcagtga tggtgatgag ttacgggaac tccgaagagg attcacaaga acataccggc     1920

agtcagttgc gtattgcggc gtatggcccg catgccgcca atgttgttgg actgaccgac     1980

cagaccgatc tcttctacac catgaaagcc gctctggggc tgaaaggcgc gccggactat     2040

aaagatgacg atgacaaagg cgcgccgcac catcatcacc atcac                     2085


<210>  20
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of the Fab region of the anti-Ambra-1 antibody 
       AbD33473

<400>  20
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt       60

agctgtagcg gcagcagcag caacattggt tacaactacg tgtactggta ccagcagctg      120

ccgggcacgg cgccgaaact gctgatctac gaaaacaaca aacgcccgag cggcgtgccg      180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa      240

gcagaagacg aagcggatta ttactgctct tcttgggact ctcattctaa ctcttacgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccagccga aagccgcccc aagcgtgacc      360

ctgtttccgc cgagcagcga agaactgcaa gccaacaaag ccaccctggt ttgcctgatc      420

agcgattttt atccgggtgc cgtgaccgtg gcctggaaag ccgatagcag cccggtgaaa      480

gccggcgtgg aaaccaccac cccgagcaaa cagagcaaca acaaatatgc cgccagcagc      540

tatctgagcc tgaccccgga acagtggaaa agccatcgca gctatagttg tcaagtgacc      600

catgaaggca gcaccgtgga aaaaaccgtg gccccgaccg aggcc                      645


<210>  21
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Val Val Pro Glu Lys Asn Ala Val Arg Ile Leu Trp Gly Arg 
1               5                   10                  15      


Glu Arg Gly Ala Arg Ala Met Gly Ala Gln Arg Leu Leu Gln Glu Leu 
            20                  25                  30          


Val Glu Asp Lys Thr Arg Trp Met Lys Trp Glu Gly Lys Arg Val Glu 
        35                  40                  45              


Leu Pro Asp Ser Pro Arg Ser Thr Phe Leu Leu Ala Phe Ser Pro Asp 
    50                  55                  60                  


Arg Thr Leu Leu Ala Ser Thr His Val Asn His Asn Ile Tyr Ile Thr 
65                  70                  75                  80  


Glu Val Lys Thr Gly Lys Cys Val His Ser Leu Ile Gly His Arg Arg 
                85                  90                  95      


Thr Pro Trp Cys Val Thr Phe His Pro Thr Ile Ser Gly Leu Ile Ala 
            100                 105                 110         


Ser Gly Cys Leu Asp Gly Glu Val Arg Ile Trp Asp Leu His Gly Gly 
        115                 120                 125             


Ser Glu Ser Trp Phe Thr Asp Ser Asn Asn Ala Ile Ala Ser Leu Ala 
    130                 135                 140                 


Phe His Pro Thr Ala Gln Leu Leu Leu Ile Ala Thr Ala Asn Glu Ile 
145                 150                 155                 160 


His Phe Trp Asp Trp Ser Arg Arg Glu Pro Phe Ala Val Val Lys Thr 
                165                 170                 175     


Ala Ser Glu Met Glu Arg Val Arg Leu Val Arg Phe Asp Pro Leu Gly 
            180                 185                 190         


His Tyr Leu Leu Thr Ala Ile Val Asn Pro Ser Asn Gln Gln Gly Asp 
        195                 200                 205             


Asp Glu Pro Glu Ile Pro Ile Asp Gly Thr Glu Leu Ser His Tyr Arg 
    210                 215                 220                 


Gln Arg Ala Leu Leu Gln Ser Gln Pro Val Arg Arg Thr Pro Leu Leu 
225                 230                 235                 240 


His Asn Phe Leu His Met Leu Ser Ser Arg Ser Ser Gly Ile Gln Val 
                245                 250                 255     


Gly Glu Gln Ser Thr Val Gln Asp Ser Ala Thr Pro Ser Pro Pro Pro 
            260                 265                 270         


Pro Pro Pro Gln Pro Ser Thr Glu Arg Pro Arg Thr Ser Ala Tyr Ile 
        275                 280                 285             


Arg Leu Arg Gln Arg Val Ser Tyr Pro Thr Ala Glu Cys Cys Gln His 
    290                 295                 300                 


Leu Gly Ile Leu Cys Leu Cys Ser Arg Cys Ser Gly Thr Arg Val Pro 
305                 310                 315                 320 


Ser Leu Leu Pro His Gln Asp Ser Val Pro Pro Ala Ser Ala Arg Ala 
                325                 330                 335     


Thr Thr Pro Ser Phe Ser Phe Val Gln Thr Glu Pro Phe His Pro Pro 
            340                 345                 350         


Glu Gln Ala Ser Ser Thr Gln Gln Asp Gln Gly Leu Leu Asn Arg Pro 
        355                 360                 365             


Ser Ala Phe Ser Thr Val Gln Ser Ser Thr Ala Gly Asn Thr Leu Arg 
    370                 375                 380                 


Asn Leu Ser Leu Gly Pro Thr Arg Arg Ser Leu Gly Gly Pro Leu Ser 
385                 390                 395                 400 


Ser His Pro Ser Arg Tyr His Arg Glu Ile Ala Pro Gly Leu Thr Gly 
                405                 410                 415     


Ser Glu Trp Thr Arg Thr Val Leu Ser Leu Asn Ser Arg Ser Glu Ala 
            420                 425                 430         


Glu Ser Met Pro Pro Pro Arg Thr Ser Ala Ser Ser Val Ser Leu Leu 
        435                 440                 445             


Ser Val Leu Arg Gln Gln Glu Gly Gly Ser Gln Ala Ser Val Tyr Thr 
    450                 455                 460                 


Ser Ala Thr Glu Gly Arg Gly Phe Pro Ala Ser Gly Leu Ala Thr Glu 
465                 470                 475                 480 


Ser Asp Gly Gly Asn Gly Ser Ser Gln Asn Asn Ser Gly Ser Ile Arg 
                485                 490                 495     


His Glu Leu Gln Cys Asp Leu Arg Arg Phe Phe Leu Glu Tyr Asp Arg 
            500                 505                 510         


Leu Gln Glu Leu Asp Gln Ser Leu Ser Gly Glu Ala Pro Gln Thr Gln 
        515                 520                 525             


Gln Ala Gln Glu Met Leu Asn Asn Asn Ile Glu Ser Glu Arg Pro Gly 
    530                 535                 540                 


Pro Ser His Gln Pro Thr Pro His Ser Ser Glu Asn Asn Ser Asn Leu 
545                 550                 555                 560 


Ser Arg Gly His Leu Asn Arg Cys Arg Ala Cys His Asn Leu Leu Thr 
                565                 570                 575     


Phe Asn Asn Asp Thr Leu Arg Trp Glu Arg Thr Thr Pro Asn Tyr Ser 
            580                 585                 590         


Ser Gly Glu Ala Ser Ser Ser Trp Gln Val Pro Ser Ser Phe Glu Ser 
        595                 600                 605             


Val Pro Ser Ser Gly Ser Gln Leu Pro Pro Leu Glu Arg Thr Glu Gly 
    610                 615                 620                 


Gln Thr Pro Ser Ser Ser Arg Leu Glu Leu Ser Ser Ser Ala Ser Pro 
625                 630                 635                 640 


Gln Glu Glu Arg Thr Val Gly Val Ala Phe Asn Gln Glu Thr Gly His 
                645                 650                 655     


Trp Glu Arg Ile Tyr Thr Gln Ser Ser Arg Ser Gly Thr Val Ser Gln 
            660                 665                 670         


Glu Ala Leu His Gln Asp Met Pro Glu Glu Ser Ser Glu Glu Asp Ser 
        675                 680                 685             


Leu Arg Arg Arg Leu Leu Glu Ser Ser Leu Ile Ser Leu Ser Arg Tyr 
    690                 695                 700                 


Asp Gly Ala Gly Ser Arg Glu His Pro Ile Tyr Pro Asp Pro Ala Arg 
705                 710                 715                 720 


Leu Ser Pro Ala Ala Tyr Tyr Ala Gln Arg Met Ile Gln Tyr Leu Ser 
                725                 730                 735     


Arg Arg Asp Ser Ile Arg Gln Arg Ser Met Arg Tyr Gln Gln Asn Arg 
            740                 745                 750         


Leu Arg Ser Ser Thr Ser Ser Ser Ser Ser Asp Asn Gln Gly Pro Ser 
        755                 760                 765             


Val Glu Gly Thr Asp Leu Glu Phe Glu Asp Phe Glu Asp Asn Gly Asp 
    770                 775                 780                 


Arg Ser Arg His Arg Ala Pro Arg Asn Ala Arg Met Ser Ala Pro Ser 
785                 790                 795                 800 


Leu Gly Arg Phe Val Pro Arg Arg Phe Leu Leu Pro Glu Tyr Leu Pro 
                805                 810                 815     


Tyr Ala Gly Ile Phe His Glu Arg Gly Gln Pro Gly Leu Ala Thr His 
            820                 825                 830         


Ser Ser Val Asn Arg Val Leu Ala Gly Ala Val Ile Gly Asp Gly Gln 
        835                 840                 845             


Ser Ala Val Ala Ser Asn Ile Ala Asn Thr Thr Tyr Arg Leu Gln Trp 
    850                 855                 860                 


Trp Asp Phe Thr Lys Phe Asp Leu Pro Glu Ile Ser Asn Ala Ser Val 
865                 870                 875                 880 


Asn Val Leu Val Gln Asn Cys Lys Ile Tyr Asn Asp Ala Ser Cys Asp 
                885                 890                 895     


Ile Ser Ala Asp Gly Gln Leu Leu Ala Ala Phe Ile Pro Ser Ser Gln 
            900                 905                 910         


Arg Gly Phe Pro Asp Glu Gly Ile Leu Ala Val Tyr Ser Leu Ala Pro 
        915                 920                 925             


His Asn Leu Gly Glu Met Leu Tyr Thr Lys Arg Phe Gly Pro Asn Ala 
    930                 935                 940                 


Ile Ser Val Ser Leu Ser Pro Met Gly Arg Tyr Val Met Val Gly Leu 
945                 950                 955                 960 


Ala Ser Arg Arg Ile Leu Leu His Pro Ser Thr Glu His Met Val Ala 
                965                 970                 975     


Gln Val Phe Arg Leu Gln Gln Ala His Gly Gly Glu Thr Ser Met Arg 
            980                 985                 990         


Arg Val Phe Asn Val Leu Tyr Pro  Met Pro Ala Asp Gln  Arg Arg His 
        995                 1000                 1005             


Val Ser  Ile Asn Ser Ala Arg  Trp Leu Pro Glu Pro  Gly Leu Gly 
    1010                 1015                 1020             


Leu Ala  Tyr Gly Thr Asn Lys  Gly Asp Leu Val Ile  Cys Arg Pro 
    1025                 1030                 1035             


Glu Ala  Leu Asn Ser Gly Val  Glu Tyr Tyr Trp Asp  Gln Leu Asn 
    1040                 1045                 1050             


Glu Thr  Val Phe Thr Val His  Ser Asn Ser Arg Ser  Ser Glu Arg 
    1055                 1060                 1065             


Pro Gly  Thr Ser Arg Ala Thr  Trp Arg Thr Asp Arg  Asp Met Gly 
    1070                 1075                 1080             


Leu Met  Asn Ala Ile Gly Leu  Gln Pro Arg Asn Pro  Ala Thr Ser 
    1085                 1090                 1095             


Val Thr  Ser Gln Gly Thr Gln  Thr Leu Ala Leu Gln  Leu Gln Asn 
    1100                 1105                 1110             


Ala Glu  Thr Gln Thr Glu Arg  Glu Val Pro Glu Pro  Gly Thr Ala 
    1115                 1120                 1125             


Ala Ser  Gly Pro Gly Glu Gly  Glu Gly Ser Glu Tyr  Gly Ala Ser 
    1130                 1135                 1140             


Gly Glu  Asp Ala Leu Ser Arg  Ile Gln Arg Leu Met  Ala Glu Gly 
    1145                 1150                 1155             


Gly Met  Thr Ala Val Val Gln  Arg Glu Gln Ser Thr  Thr Met Ala 
    1160                 1165                 1170             


Ser Met  Gly Gly Phe Gly Asn  Asn Ile Ile Val Ser  His Arg Ile 
    1175                 1180                 1185             


His Arg  Ser Ser Gln Thr Gly  Thr Glu Pro Gly Ala  Ala His Thr 
    1190                 1195                 1200             


Ser Ser  Pro Gln Pro Ser Thr  Ser Arg Gly Leu Leu  Pro Glu Ala 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Arg Gly  Leu Ser Pro Arg Thr  Ala Ser Trp 
    1220                 1225                 1230             


Asp Gln  Pro Gly Thr Pro Gly  Arg Glu Pro Thr Gln  Pro Thr Leu 
    1235                 1240                 1245             


Pro Ser  Ser Ser Pro Val Pro  Ile Pro Val Ser Leu  Pro Ser Ala 
    1250                 1255                 1260             


Glu Gly  Pro Thr Leu His Cys  Glu Leu Thr Asn Asn  Asn His Leu 
    1265                 1270                 1275             


Leu Asp  Gly Gly Ser Ser Arg  Gly Asp Ala Ala Gly  Pro Arg Gly 
    1280                 1285                 1290             


Glu Pro  Arg Asn Arg 
    1295             


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide to which anti-Ambra-1 antibodies were raised

<400>  22

Cys Gly Gly Ser Ser Arg Gly Asp Ala Ala Gly Pro Arg Gly Glu Pro 
1               5                   10                  15      


Arg Asn Arg 
            


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of anti-p62 antibody AbD34907

<400>  23

Thr Tyr Tyr Leu His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of the anti-p62 antibody AbD34907

<400>  24

Leu Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of the anti-p62 antibody AbD34907

<400>  25

Gly Pro Gly Arg Leu Arg Pro Phe Gly Leu Tyr Phe Asp Val 
1               5                   10                  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of the anti-p62 antibody AbD34907

<400>  26

Arg Ala Ser Gln Gly Ile Tyr Thr Phe Leu Asn 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of the anti-p62 antibody AbD34907

<400>  27

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of the anti-p62 antibody AbD34907

<400>  28

Phe Gln Tyr Ser Ser Trp Pro Arg Thr 
1               5                   


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR1 of the anti-p62 antibody AbD34907

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn 
            20                  25                  30  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR2 of the anti-p62 antibody AbD34907

<400>  30

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR3 of the anti-p62 antibody AbD34907

<400>  31

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR4 of the anti-p62 antibody AbD34907

<400>  32

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR1 of the anti-p62 antibody AbD34907

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR2 of the anti-p62 antibody AbD34907

<400>  34

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR3 of the anti-p62 antibody AbD34907

<400>  35

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR4 of the anti-p62 antibody AbD34907

<400>  36

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  37
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of the anti-p62 antibody AbD34907

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Thr Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Gly Arg Leu Arg Pro Phe Gly Leu Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of the anti-p62 antibody AbD34907

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Tyr Ser Ser Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fd chain (VH domain and constant domain) of the Fab region of the
       anti-p62 antibody AbD34907

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Thr Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Gly Arg Leu Arg Pro Phe Gly Leu Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser 
225 


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain (VL domain and constant domain) of the Fab region of 
       the anti-p62 antibody AbD34907

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Tyr Ser Ser Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Ala 
    210                 


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of anti-p62 antibody AbD34908

<400>  41

Asn Tyr Trp Ile Gly 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of the anti-p62 antibody AbD34908

<400>  42

Ile Ile Asp Pro Ser Gly Ser Phe Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of the anti-p62 antibody AbD34908

<400>  43

Lys Tyr Val Pro Pro Val Tyr Ser Tyr Trp Ser Tyr Gly Thr Leu Asp 
1               5                   10                  15      


Val 
    


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of the anti-p62 antibody AbD34908

<400>  44

Arg Ala Ser Gln Ser Val Ser Ala Ser Arg Leu Ala 
1               5                   10          


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of the anti-p62 antibody AbD34908

<400>  45

Gly Ser Ser Thr Arg Ala Thr 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of the anti-p62 antibody AbD34908

<400>  46

Gln Gln Tyr Leu His Leu Tyr Thr 
1               5               


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR1 of the anti-p62 antibody AbD34908

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR2 of the anti-p62 antibody AbD34908

<400>  48

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR3 of the anti-p62 antibody AbD34908

<400>  49

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR4 of the anti-p62 antibody AbD34908

<400>  50

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  51
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR1 of the anti-p62 antibody AbD34908

<400>  51

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR2 of the anti-p62 antibody AbD34908

<400>  52

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  53
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR3 of the anti-p62 antibody AbD34908

<400>  53

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR4 of the anti-p62 antibody AbD34908

<400>  54

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  55
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of the anti-p62 antibody AbD34908

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Gly Ser Phe Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Tyr Val Pro Pro Val Tyr Ser Tyr Trp Ser Tyr Gly Thr 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of the anti-p62 antibody AbD34908

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ala Ser 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Leu His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  57
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fd chain (VH domain and constant domain) of the Fab region of the
       anti-p62 antibody AbD34908

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Gly Ser Phe Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Tyr Val Pro Pro Val Tyr Ser Tyr Trp Ser Tyr Gly Thr 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser 
225             


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain (VL domain and constant domain) of the Fab region of 
       the anti-p62 antibody AbD34908

<400>  58

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ala Ser 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Leu His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Ala 
    210                 


<210>  59
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full amino acid sequence of the anti-p62 antibody AbD34907 
       including alkaline phosphatase dimerization domain sequence (AP),
       FLAG and His6 tag

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Tyr Ser Ser Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
    210                 215                 220                 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
225                 230                 235                 240 


Tyr Thr Phe Asn Thr Tyr Tyr Leu His Trp Val Arg Gln Ala Pro Gly 
                245                 250                 255     


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Asn Asn Gly Gly Thr 
            260                 265                 270         


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
        275                 280                 285             


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Glu Asp 
    290                 295                 300                 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Gly Arg Leu Arg Pro Phe 
305                 310                 315                 320 


Gly Leu Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                325                 330                 335     


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
            340                 345                 350         


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
        355                 360                 365             


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
    370                 375                 380                 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
                405                 410                 415     


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
            420                 425                 430         


Lys Lys Val Glu Pro Lys Ser Glu Phe Lys Ala Glu Met Pro Val Leu 
        435                 440                 445             


Glu Asn Arg Ala Ala Gln Gly Asp Ile Thr Thr Pro Gly Gly Ala Arg 
    450                 455                 460                 


Arg Leu Thr Gly Asp Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp 
465                 470                 475                 480 


Lys Pro Ala Lys Asn Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp 
                485                 490                 495     


Ser Glu Ile Thr Ala Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe 
            500                 505                 510         


Phe Lys Gly Ile Asp Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr 
        515                 520                 525             


Ala Leu Asn Arg Lys Thr Gly Lys Pro Asp Tyr Val Thr Ser Ser Ala 
    530                 535                 540                 


Ala Ser Ala Thr Ala Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala 
545                 550                 555                 560 


Leu Gly Val Asp Ile His Glu Lys Asp His Pro Thr Ile Leu Glu Met 
                565                 570                 575     


Ala Lys Ala Ala Gly Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu 
            580                 585                 590         


Gln Asp Ala Thr Pro Ala Ala Leu Val Ala His Val Thr Ser Arg Lys 
        595                 600                 605             


Cys Tyr Gly Pro Ser Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu 
    610                 615                 620                 


Glu Lys Gly Gly Lys Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg 
625                 630                 635                 640 


Ala Asp Val Thr Leu Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala 
                645                 650                 655     


Thr Ala Gly Glu Trp Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala 
            660                 665                 670         


Arg Gly Tyr Gln Leu Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr 
        675                 680                 685             


Glu Ala Asn Gln Gln Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn 
    690                 695                 700                 


Met Pro Val Arg Trp Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile 
705                 710                 715                 720 


Asp Lys Pro Ala Val Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser 
                725                 730                 735     


Val Pro Thr Leu Ala Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser 
            740                 745                 750         


Lys Asn Glu Lys Gly Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp 
        755                 760                 765             


Lys Gln Asp His Ala Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val 
    770                 775                 780                 


Asp Leu Asp Glu Ala Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Glu 
785                 790                 795                 800 


Gly Asn Thr Leu Val Ile Val Thr Ala Asp His Ala His Ala Ser Gln 
                805                 810                 815     


Ile Val Ala Pro Asp Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn 
            820                 825                 830         


Thr Lys Asp Gly Ala Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu 
        835                 840                 845             


Asp Ser Gln Glu His Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly 
    850                 855                 860                 


Pro His Ala Ala Asn Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe 
865                 870                 875                 880 


Tyr Thr Met Lys Ala Ala Leu Gly Leu Lys Gly Ala Pro Asp Tyr Lys 
                885                 890                 895     


Asp Asp Asp Asp Lys Gly Ala Pro His His His His His His 
            900                 905                 910 


<210>  60
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full amino acid sequence of the anti-p62 antibody AbD34908

       including alkaline phosphatase dimerization domain sequence (AP),
       FLAG and His6 tag

<400>  60

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ala Ser 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Leu His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
    210                 215                 220                 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
225                 230                 235                 240 


Tyr Ser Phe Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
                245                 250                 255     


Lys Gly Leu Glu Trp Met Gly Ile Ile Asp Pro Ser Gly Ser Phe Thr 
            260                 265                 270         


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
        275                 280                 285             


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
    290                 295                 300                 


Thr Ala Met Tyr Tyr Cys Ala Arg Lys Tyr Val Pro Pro Val Tyr Ser 
305                 310                 315                 320 


Tyr Trp Ser Tyr Gly Thr Leu Asp Val Trp Gly Gln Gly Thr Leu Val 
                325                 330                 335     


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
            340                 345                 350         


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
        355                 360                 365             


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
    370                 375                 380                 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
385                 390                 395                 400 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
                405                 410                 415     


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
            420                 425                 430         


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Glu Phe Lys Ala Glu Met 
        435                 440                 445             


Pro Val Leu Glu Asn Arg Ala Ala Gln Gly Asp Ile Thr Thr Pro Gly 
    450                 455                 460                 


Gly Ala Arg Arg Leu Thr Gly Asp Gln Thr Ala Ala Leu Arg Asp Ser 
465                 470                 475                 480 


Leu Ser Asp Lys Pro Ala Lys Asn Ile Ile Leu Leu Ile Gly Asp Gly 
                485                 490                 495     


Met Gly Asp Ser Glu Ile Thr Ala Ala Arg Asn Tyr Ala Glu Gly Ala 
            500                 505                 510         


Gly Gly Phe Phe Lys Gly Ile Asp Ala Leu Pro Leu Thr Gly Gln Tyr 
        515                 520                 525             


Thr His Tyr Ala Leu Asn Arg Lys Thr Gly Lys Pro Asp Tyr Val Thr 
    530                 535                 540                 


Ser Ser Ala Ala Ser Ala Thr Ala Trp Ser Thr Gly Val Lys Thr Tyr 
545                 550                 555                 560 


Asn Gly Ala Leu Gly Val Asp Ile His Glu Lys Asp His Pro Thr Ile 
                565                 570                 575     


Leu Glu Met Ala Lys Ala Ala Gly Leu Ala Thr Gly Asn Val Ser Thr 
            580                 585                 590         


Ala Glu Leu Gln Asp Ala Thr Pro Ala Ala Leu Val Ala His Val Thr 
        595                 600                 605             


Ser Arg Lys Cys Tyr Gly Pro Ser Ala Thr Ser Glu Lys Cys Pro Gly 
    610                 615                 620                 


Asn Ala Leu Glu Lys Gly Gly Lys Gly Ser Ile Thr Glu Gln Leu Leu 
625                 630                 635                 640 


Asn Ala Arg Ala Asp Val Thr Leu Gly Gly Gly Ala Lys Thr Phe Ala 
                645                 650                 655     


Glu Thr Ala Thr Ala Gly Glu Trp Gln Gly Lys Thr Leu Arg Glu Gln 
            660                 665                 670         


Ala Gln Ala Arg Gly Tyr Gln Leu Val Ser Asp Ala Ala Ser Leu Asn 
        675                 680                 685             


Ser Val Thr Glu Ala Asn Gln Gln Lys Pro Leu Leu Gly Leu Phe Ala 
    690                 695                 700                 


Asp Gly Asn Met Pro Val Arg Trp Leu Gly Pro Lys Ala Thr Tyr His 
705                 710                 715                 720 


Gly Asn Ile Asp Lys Pro Ala Val Thr Cys Thr Pro Asn Pro Gln Arg 
                725                 730                 735     


Asn Asp Ser Val Pro Thr Leu Ala Gln Met Thr Asp Lys Ala Ile Glu 
            740                 745                 750         


Leu Leu Ser Lys Asn Glu Lys Gly Phe Phe Leu Gln Val Glu Gly Ala 
        755                 760                 765             


Ser Ile Asp Lys Gln Asp His Ala Ala Asn Pro Cys Gly Gln Ile Gly 
    770                 775                 780                 


Glu Thr Val Asp Leu Asp Glu Ala Val Gln Arg Ala Leu Glu Phe Ala 
785                 790                 795                 800 


Lys Lys Glu Gly Asn Thr Leu Val Ile Val Thr Ala Asp His Ala His 
                805                 810                 815     


Ala Ser Gln Ile Val Ala Pro Asp Thr Lys Ala Pro Gly Leu Thr Gln 
            820                 825                 830         


Ala Leu Asn Thr Lys Asp Gly Ala Val Met Val Met Ser Tyr Gly Asn 
        835                 840                 845             


Ser Glu Glu Asp Ser Gln Glu His Thr Gly Ser Gln Leu Arg Ile Ala 
    850                 855                 860                 


Ala Tyr Gly Pro His Ala Ala Asn Val Val Gly Leu Thr Asp Gln Thr 
865                 870                 875                 880 


Asp Leu Phe Tyr Thr Met Lys Ala Ala Leu Gly Leu Lys Gly Ala Pro 
                885                 890                 895     


Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Pro His His His His His 
            900                 905                 910         


His 
    


<210>  61
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Ser Leu Thr Val Lys Ala Tyr Leu Leu Gly Lys Glu Asp Ala 
1               5                   10                  15      


Ala Arg Glu Ile Arg Arg Phe Ser Phe Cys Cys Ser Pro Glu Pro Glu 
            20                  25                  30          


Ala Glu Ala Glu Ala Ala Ala Gly Pro Gly Pro Cys Glu Arg Leu Leu 
        35                  40                  45              


Ser Arg Val Ala Ala Leu Phe Pro Ala Leu Arg Pro Gly Gly Phe Gln 
    50                  55                  60                  


Ala His Tyr Arg Asp Glu Asp Gly Asp Leu Val Ala Phe Ser Ser Asp 
65                  70                  75                  80  


Glu Glu Leu Thr Met Ala Met Ser Tyr Val Lys Asp Asp Ile Phe Arg 
                85                  90                  95      


Ile Tyr Ile Lys Glu Lys Lys Glu Cys Arg Arg Asp His Arg Pro Pro 
            100                 105                 110         


Cys Ala Gln Glu Ala Pro Arg Asn Met Val His Pro Asn Val Ile Cys 
        115                 120                 125             


Asp Gly Cys Asn Gly Pro Val Val Gly Thr Arg Tyr Lys Cys Ser Val 
    130                 135                 140                 


Cys Pro Asp Tyr Asp Leu Cys Ser Val Cys Glu Gly Lys Gly Leu His 
145                 150                 155                 160 


Arg Gly His Thr Lys Leu Ala Phe Pro Ser Pro Phe Gly His Leu Ser 
                165                 170                 175     


Glu Gly Phe Ser His Ser Arg Trp Leu Arg Lys Val Lys His Gly His 
            180                 185                 190         


Phe Gly Trp Pro Gly Trp Glu Met Gly Pro Pro Gly Asn Trp Ser Pro 
        195                 200                 205             


Arg Pro Pro Arg Ala Gly Glu Ala Arg Pro Gly Pro Thr Ala Glu Ser 
    210                 215                 220                 


Ala Ser Gly Pro Ser Glu Asp Pro Ser Val Asn Phe Leu Lys Asn Val 
225                 230                 235                 240 


Gly Glu Ser Val Ala Ala Ala Leu Ser Pro Leu Gly Ile Glu Val Asp 
                245                 250                 255     


Ile Asp Val Glu His Gly Gly Lys Arg Ser Arg Leu Thr Pro Val Ser 
            260                 265                 270         


Pro Glu Ser Ser Ser Thr Glu Glu Lys Ser Ser Ser Gln Pro Ser Ser 
        275                 280                 285             


Cys Cys Ser Asp Pro Ser Lys Pro Gly Gly Asn Val Glu Gly Ala Thr 
    290                 295                 300                 


Gln Ser Leu Ala Glu Gln Met Arg Lys Ile Ala Leu Glu Ser Glu Gly 
305                 310                 315                 320 


Arg Pro Glu Glu Gln Met Glu Ser Asp Asn Cys Ser Gly Gly Asp Asp 
                325                 330                 335     


Asp Trp Thr His Leu Ser Ser Lys Glu Val Asp Pro Ser Thr Gly Glu 
            340                 345                 350         


Leu Gln Ser Leu Gln Met Pro Glu Ser Glu Gly Pro Ser Ser Leu Asp 
        355                 360                 365             


Pro Ser Gln Glu Gly Pro Thr Gly Leu Lys Glu Ala Ala Leu Tyr Pro 
    370                 375                 380                 


His Leu Pro Pro Glu Ala Asp Pro Arg Leu Ile Glu Ser Leu Ser Gln 
385                 390                 395                 400 


Met Leu Ser Met Gly Phe Ser Asp Glu Gly Gly Trp Leu Thr Arg Leu 
                405                 410                 415     


Leu Gln Thr Lys Asn Tyr Asp Ile Gly Ala Ala Leu Asp Thr Ile Gln 
            420                 425                 430         


Tyr Ser Lys His Pro Pro Pro Leu 
        435                 440 


<210>  62
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p62 protein fragment used to generate anti-p62 antibodies

<400>  62

Met Ala Met Ser Tyr Val Lys Asp Asp Ile Phe Arg Ile Tyr Ile Lys 
1               5                   10                  15      


Glu Lys Lys Glu Cys Arg Arg Asp His Arg Pro Pro Cys Ala Gln Glu 
            20                  25                  30          


Ala Pro Arg Asn Met Val His Pro Asn Val Ile Cys Asp Gly Cys Asn 
        35                  40                  45              


Gly Pro Val Val Gly Thr Arg Tyr Lys Cys Ser Val Cys Pro Asp Tyr 
    50                  55                  60                  


Asp Leu Cys Ser Val Cys Glu Gly Lys Gly Leu His Arg Gly His Thr 
65                  70                  75                  80  


Lys Leu Ala Phe Pro Ser Pro Phe Gly His Leu Ser Glu Gly Phe Ser 
                85                  90                  95      


His Ser Arg Trp Leu Arg Lys Val Lys His Gly His Phe Gly Trp Pro 
            100                 105                 110         


Gly Trp Glu Met Gly Pro Pro Gly Asn Trp Ser Pro Arg Pro Pro Arg 
        115                 120                 125             


Ala Gly Glu Ala Arg Pro Gly Pro Thr Ala Glu Ser Ala Ser Gly Pro 
    130                 135                 140                 


Ser Glu Asp Pro Ser Val Asn Phe Leu Lys Asn Val Gly Glu Ser Val 
145                 150                 155                 160 


Ala Ala Ala Leu Ser Pro Leu Gly Ile Glu Val Asp Ile Asp Val Glu 
                165                 170                 175     


His Gly Gly Lys Arg Ser Arg Leu Thr Pro Val Ser Pro Glu Ser Ser 
            180                 185                 190         


Ser Thr Glu Glu Lys Ser Ser Ser Gln Pro Ser Ser Cys Cys Ser Asp 
        195                 200                 205             


Pro Ser Lys Pro Gly Gly Asn Val Glu Gly Ala Thr Gln Ser Leu Ala 
    210                 215                 220                 


Glu Gln Met Arg Lys Ile Ala Leu Glu Ser Glu Gly Arg Pro Glu Glu 
225                 230                 235                 240 


Gln Met Glu Ser Asp Asn Cys Ser Gly Gly Asp Asp Asp Trp Thr His 
                245                 250                 255     


Leu Ser Ser Lys Glu Val Asp Pro Ser Thr Gly Glu Leu Gln Ser Leu 
            260                 265                 270         


Gln Met Pro Glu Ser Glu Gly Pro Ser Ser Leu Asp Pro Ser Gln Glu 
        275                 280                 285             


Gly Pro Thr Gly Leu Lys Glu Ala Ala Leu Tyr Pro His Leu Pro Pro 
    290                 295                 300                 


Glu Ala Asp Pro Arg Leu Ile Glu Ser Leu Ser Gln Met Leu Ser Met 
305                 310                 315                 320 


Gly Phe Ser Asp Glu Gly Gly Trp Leu Thr Arg Leu Leu Gln Thr Lys 
                325                 330                 335     


Asn Tyr Asp Ile Gly Ala Ala Leu Asp Thr Ile Gln Tyr Ser Lys His 
            340                 345                 350         


Pro Pro Pro Leu Leu Glu His His His His His His 
        355                 360                 


<210>  63
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ambra-1 C-terminal sequence used for replacement analysis in 
       epitope mapping

<400>  63

Val Ser Leu Pro Ser Ala Glu Gly Pro Thr Leu His Cys Glu Leu Thr 
1               5                   10                  15      


Asn Asn Asn His Leu Leu Asp Gly Gly Ser Ser Arg Gly Asp Ala Ala 
            20                  25                  30          


Gly Pro Arg Gly Glu Pro Arg Asn Arg 
        35                  40      


<210>  64
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REPNET epitope of the Anti-Ambra-1 antibodies

<400>  64

Asp Gly Gly Ser Ser Arg Gly Asp Ala Ala Gly Pro Arg Gly Glu Pro 
1               5                   10                  15      


Arg Asn Arg 
            


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN epitope of the Anti-Ambra-1 antibodies

<400>  65

His Leu Leu Asp Gly Gly Ser Ser Arg 
1               5                   


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LOOP epitope of the Anti-Ambra-1 antibodies

<400>  66

Asn His Leu Leu Asp Gly Gly Ser Ser Arg 
1               5                   10  


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope of the Anti-Ambra-1 antibodies

<400>  67

Glu Pro Arg Asn 
1               


<210>  68

<400>  68
000

<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPITOPE TAG

<400>  69

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPITOPE TAG

<400>  70

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPITOPE TAG

<400>  71

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


