                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
 
<120>  CRISPR/CAS ALL-IN-TWO VECTOR SYSTEMS FOR TREATMENT OF DMD

<130>  AD2319 PCT S3

<140>  PCT/IB2020/000377
<141>  2020-05-08

<150>  US 62/845,197
<151>  2019-05-08

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L01

<400>  1
ctgagtagga gctaaaatat t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L02

<400>  2
acaataagtc aaatttaatt g                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L03

<400>  3
aagatatata atgtcatgaa t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L16

<400>  4
aatggttaag atgcatagta c                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L18

<400>  5
tatgtggctt taccaaggtc c                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L22

<400>  6
gtgtattgct tgtactactc a                                                 21


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L34

<400>  7
tctcctcatt agagaagaag                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L37

<400>  8
ctcaagcttc tcagggacac c                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L45

<400>  9
atcctcacac atgcatcctc t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L52

<400>  10
aaagtgaagg atgaggaact a                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L57

<400>  11
aaattagctg aagcatattc a                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L61

<400>  12
tcttgcatct tgcacatgtc c                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L64

<400>  13
cttagaggtc ttctacatac a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L81

<400>  14
ttctgactgt aagtacacta t                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L84

<400>  15
tctggagggt caaatctggt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L85

<400>  16
aatggagaga ggtaagtctg                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L88

<400>  17
tgaaatggcc tgtgctcatg a                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R6

<400>  18
aactggtggg aaatggtcta g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R7

<400>  19
attatactta ggctgaatag t                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R11

<400>  20
tttaaatgta aatagctcag                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R14

<400>  21
tggcacagac aacttagaag a                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R15

<400>  22
aaattggcac agacaactta g                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R22

<400>  23
aaaaacaaga agtgaggcag a                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R26

<400>  24
ctgcatttaa aggccttgag c                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R32

<400>  25
ctattctgag tacagagcat a                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R41

<400>  26
agcaagtaat aacacaagct t                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R42

<400>  27
gtgttattac ttgctactgc a                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R52

<400>  28
acacttcctt gtgacgggtt t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R53

<400>  29
attgatgtgc tcagtagtct c                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R91

<400>  30
ttacacacag gatggagaaa a                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R99

<400>  31
gcaattctcc tgaatagaaa                                                   20


<210>  32
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L64 gRNA

<400>  32
cttagaggtc ttctacatac agtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  33
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L81 gRNA

<400>  33
ttctgactgt aagtacacta tgtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  34
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R32 gRNA

<400>  34
ctattctgag tacagagcat agtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  35
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: LT2 gRNA

<400>  35
actatgatta aatgcttgat agtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  36
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: RT2 gRNA

<400>  36
cttaaaggct tcatataagg ggtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  37
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: V25 gRNA

<400>  37
cgttggagcg gggagaaggc cgtttaagta ctctgtgctg gaaacagcac agaatctact       60

taaacaaggc aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tttt            114


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L64BS

<400>  38
actcattgta tgtagaagac ctctaag                                           27


<210>  39
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L81BS

<400>  39
atccacatag tgtacttaca gtcagaa                                           27


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R32BS

<400>  40
ctattctgag tacagagcat acagagt                                           27


<210>  41
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5 AAV ITR

<400>  41
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  42
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: U6 Promoter

<400>  42
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210>  43
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3ITR

<400>  43
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  44
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Albumin

<400>  44
agaaaacgcc agtaagtgac agagtcacaa atgactgcac agagtccttg gtgaacaggc       60

gaccatgctt ttcagctctg gaagtcgtga aaacatacgt tcccaaagag ttttgaactg      120

aaaacttcac cttccatgca gatatatgca cactttctga gaaggagaga caaatcaaga      180

aacaaactgc acttgttgag cttgtgaaac acaagcccaa ggcaacaaaa gagcaactga      240

aagctgtttg agatgatttc gcagcttttg tagagaagtg ctgcaaggct gacgataagg      300

agacctgctt tgccgaggag ggtaaaaaac ttgttgctgc aagtcaagct gccttaggct      360

tataacatct acatttaaaa gactctcagc ctacctgaag aataagagaa agaaatgaaa      420

gatcaaaagc ttattcatct gttttctttt tcgttggtgt aaagccaaca ccctgtctaa      480

aaaacataaa tttctttaat cattttgcct cttttctctg tgcttcaatt aataaaaaat      540

ggaaagaatc taatagagtg gtacagcact gttatttttc aaagatgtgt tgctatcctg      600

aaaattctgt aggttctgtg gaagttccag tgttctctct tattccactt cggtagagga      660

tttctagttt ctgtgggcta attaaataaa tcactaatac tcttctaagt taagtttgca      720

gaagtttcca agttagtgac agatcttacc aaagtccaca cggaatgctg cctgagagat      780

ctgcttgaat gtgctgatga cagggcggac cttgccaagt atatctgtga aaatcaggat      840

tcgatctcca gtaaactgaa ggaatgctgt gaaaaacctc tgttggaaaa atcccactgc      900

attgccgaag tggaaaatga tgagtgacct gctgacttgc cttacttagc tgctgatttt      960

gttgaaagta aggtgatttg caaaaacttg actgaggcaa aggatgtctt cctgggctga     1020

tttttgtatg aatatgcaag aaggactcct gattactctg tcgtgctgct gctgagactt     1080

gccaagaact atgaaaccac agatctgaag tgctgtgccg ctgcagatcc tactgaatgc     1140

tatgccaaag tgttcgatga atttaaacct cttgtggaag agcctcagaa tttaatcaaa     1200

caaaactgtg agctttttga gcagcttgga gagtacaaat tccagaatgc gctattagtt     1260

cgttacacca agaaagtacc ccaagtgtca actccaactc ttgtagaggt ctcaagaaac     1320

ctcggaaaag tgggcagcaa atgttgtaaa catcctgaag caaaaagatg accctgtgca     1380

gaagactatc tatccgtggt cctgaaccag ttatgtgtgt tgcatgagga tgtcttctgg     1440

caatttcata taagtatttt ttcaaaatga tctcttctgt caaccccacg cctttggcac     1500

atgaaagtgg gtaaccttta tttcccttct ttttctcttt agctcggctt attccagggg     1560

tgtgtttcgt cgagatgcac acaagagtga ggttgctact cggtttaaag atttgggaga     1620

agaaaatttc aaagccttgg tgttgattgc ctttgctcag tatcttcagc agtgtccatt     1680

tgaagatact gtaaaattag tgaatgaagt aactgaattt gcaaaaaact gtgtagctgt     1740

gaagtcagct gaaaattgtg acaaatcact tcataccctt tttggagaca aattatgcac     1800

agttgcaact cttcgtgaaa ccttgagtga atgagctgac tgctgtgcaa aacaagaacc     1860

tgagagatga aaatgcttct tgcaacacaa agtgaacaac ccaaacctcc cccgattggt     1920

cagaccagag gttgatgtgt gatgcactgc ttttactgac aatgaagaga catttttgaa     1980

aaaatactta ttgaaaattg ccagaagaac tccttacttt ttgaccccgg aactcctttt     2040

ctttgctaaa aggtataaag ctgcttttac agaatgttgc caagctgctg ataaagctgc     2100

ctgcctgttg ccaaagctcg tgaaacttcg ggtgaaaggg aaggcttcgt ctgccaaaca     2160

gagactctga aatgccagtc tccaaaaatt tggagaaaga gctttcaaag catgggcagt     2220

ggctcgcctg agccagagat ttcccaaagc tga                                  2253


<210>  45
<211>  4014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: HPRT

<400>  45
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgtggagc agtacggcga cgaagtttaa      420

gtactctgtg ctggaaacag cacagaatct acttaaacaa ggcaaaatgc cgtgtttatc      480

tcgtcaactt gttggcgaga tttttttcac cggtggcaca cactgtagtt catctttaca      540

tggcctcatt gaagactaca gctctggtat gcgtataagg aactagcatt aggtcatttc      600

aagccgatgc tagaatccag attccatgct gaccgatgag gatatagtga gaatctttca      660

agaacattct taaccgttgg tatcttagct ccaccctcac tggttcttcc ggccaagctg      720

ctggcctccc tcctcaaccg ttctgatcat gcttgcttag tcggccagtt aagcctgatt      780

atgacctggt tacctgttgt ctaagggcag gaatcaccgc cgtaactcta gcacttagca      840

cagtacttgg cttgtaagag gtcctcgatg atgtgaatac attaaataat taacctaaga      900

aagatttcat attaggcatt gtaatgactt aaggtaaaga gcagtgctat taacaatcca      960

gcttgtttgg gctattgtgg ctgtgggcac ctctctgggt gtatatctga ggtgctggct     1020

acctcttgga ggattataag acaatcagca acccttgcat ggtggcaaca gtaataatag     1080

ccatccttac atagtcctac agccctgtag caatggtcca acagatgagg aacctttgaa     1140

gcctcagaga ggctaacaga cagaccctag gtcatacagt tattaagaga aggcgaacct     1200

ctctcgagta ataccagtta ataggctaca caaatggtag tggctgttgt attcagttgc     1260

tgaggaatgc taaacataat tctgccaatt tccgcacccg acttcccggg ctcgggtgat     1320

tctagggctg tgtcatttgt atacgctctt gttgcccggg ctggagtaca gtggcctcag     1380

tgctcccggg ttccctacct catgcgcctg tataatagag acgaggtttc acaggctacc     1440

tgatccagtg aatatttgta ttgtagagat ggtggccatg ttcctgagct caagcgatct     1500

gcccgcctct ggccaccgtg cctggcctag gtagacgcag cgtgatgcct gagtatatag     1560

tgatgctaga gctggctgtt tgttagcttt gaacataaga tactcattgt agtttgcaaa     1620

tccctcttcc taatttcttt cccttaaatt gtttgcatgt tagcgcttaa atggtgctat     1680

gtgctagaag ccttaaatta cacaaatcag agaggtgccc aactttgaac ctaagctgct     1740

cttaatctct aaacaagtta gtagtgacaa tagtaggata cttaactatg aggcatagca     1800

ggcattatca ccctaaagtg taccctttag gtaagtatat acttgcccaa tatcacttat     1860

caaatgtgtc tgatacaacc caaactatcg aaactgccag ggtaaacttg gacacacttg     1920

agctaagaat taagtcctag aaatgtaatc ctgccctagc cgagcttacc ctgcagaatt     1980

ggtcggagca ccgtccttgg ccacactgtt atcaacaggg tgtcaatctg taggaattac     2040

tctttgtgac caccaggaaa tagagcagtt cagttcattt ctttctcact gtgacctgca     2100

tactacaagt ctactttgct atccattgtt tgtatctggg tattaccaga tcagcagaga     2160

agagttgcct tggagcagct gcagttcatt agatagtaac taggccatgt caactccctt     2220

gtagtgaaga ttgtactggt acctttctgt aaatattgtg tagatcaatc accacctcaa     2280

cccagtggct gccaaattac aataattcac tactactaag ataatctact agttcgatca     2340

catacttcct actgtcttca gcattgtgct tctgattata attgtccaga gtgaacatgt     2400

ctattcttcc actgtacaca ctaatggatt gtaatattgg gtaaattcat gtccttacac     2460

atgtagtagt tatgagccca tgtccctaga atgagtaata accttggttg aatagtcaag     2520

aatgctgaaa ttcttctaac agcagaaggg aaggcaagca agtgttactg ataagatgaa     2580

tctactatta gctttaatta tacatttagg aatattgcat cagtaactca taaggctgtt     2640

atcctgagtt aacacaaatt atccaaggag atctgctttg aggtgtgagt gtatctgatg     2700

ccaactagca attccagaag tttggaatta aattatggtt tatctattgt tatacctcaa     2760

ttatatcatg tttgctgtgc tctcggctca ctctagccac cgactccctc tgagccttgc     2820

agggtagaga caggattggc caggatggtc tccatcatga tcggcctcgt gggagccact     2880

acgcctggcc atagactcac ttccattaag tcttgtttgg acccacgaac attgtcttta     2940

agatggagtt tcacgttgcc cagactgtag tgcaatggtg caatctcagc tcactgcaac     3000

caattctcct cccgagtagc tggaattaca ggcgcccgcc accacggtgt ttcaccggcc     3060

atgatccgcc cacctcagcc tcgtgtgagc caccgcatct ggccaacatg tcttcctaga     3120

cttaagcaca gatgatgaat tgatgtgtct tagcttggat taacttgctt actgtaaaga     3180

taatatagct tgacatgaag gccattatta cagatgtgac gtgcataatt attagtatta     3240

catgggtcag tctggcaatt atgaagaata atgccagaca tttcagtaat cgattatagc     3300

gtattgacag tccagacgtc agaatttctc aatactcttt cagattaatg tacctgtagc     3360

gatatcattc acaagtatat cacaagtaag ttagaatttg agaactgtgt tctagagatg     3420

cagtcagatt tctgaactgt ctcagcaaat ggagagctag taattaataa cctgtccttt     3480

gatttctgat tcagccaaga atggccatat ttgggaagga gagtaaccac gcattcattt     3540

accacagagc tctcagctta aagccataca ggaccgtgat ctgttctagc catatgtagc     3600

atttatgtcc tagtgtgatg gtatttggag acagggcctt tggaaggtaa ttgaagtggg     3660

cccaggtctg attggattag tgcgggcgca caaggccaat cacgaggtca gccagcctgg     3720

ccaatgtagt gaaacaccaa cattagctgg gtgtggtagc gggctcctgt catccaagct     3780

acgaggcatg agaatcggga cagattgtgc cactgtgggt gactcaagag acaccagaga     3840

gcttgttaga agaggtcatg tgagcacgac cttcaagcca aagaagaggc ctgagattga     3900

aacctacctt gcaggtattc cgtgagaaat aagtttctgt taagtcactc agtctgtggt     3960

agttatggca gcctgagcag gtagttgttc tttcagaagg tgttgataat caga           4014


<210>  46
<211>  1053
<212>  PRT
<213>  S. aureus


<220>
<221>  misc_feature
<222>  (1)..(1053)
<223>  Wild-type  S. aureus Cas9

<400>  46

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  47
<211>  1053
<212>  PRT
<213>  S. aureus


<220>
<221>  misc_feature
<222>  (1)..(1053)
<223>  S. aureus Cas9 D10 variant

<400>  47

Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  48
<211>  1053
<212>  PRT
<213>  S. aureus


<220>
<221>  misc_feature
<222>  (1)..(1053)
<223>  S. aureus N580A variant

<400>  48

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  49
<211>  1053
<212>  PRT
<213>  S. aureus


<220>
<221>  misc_feature
<222>  (1)..(1053)
<223>  S. aureus D10 & N580A variant

<400>  49

Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  50
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: R42BS

<400>  50
gtgttattac ttgctactgc agagagt                                           27


<210>  51
<211>  595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CMV Promoter

<400>  51
ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt       60

agtcagcaac cacgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      120

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      180

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      240

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      300

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      360

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      420

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      480

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      540

cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgt           595


<210>  52
<211>  3225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: SaCas9

<400>  52
atggccccaa agaagaagcg gaaggtcgga tccggaaagc ggaactatat cctgggactg       60

gacatcggaa ttacctccgt gggatacggc atcatcgatt acgagactag ggacgtgatt      120

gacgccggcg tgagactctt taaggaggcc aacgtggaaa acaacgaagg tcgcagatcc      180

aagcggggtg caagacgcct gaagcgccgg aggagacatc ggatacagcg cgtgaagaag      240

ctccttttcg actacaacct cctcactgac cactcggaat tgtccggtat caacccctac      300

gaagcccgcg tgaaaggcct gagccagaag ctgtccgaag aggagtttag cgcagccctg      360

ctgcacctgg ctaagcgaag gggggtgcac aacgtgaacg aggtggagga ggacactggc      420

aacgaactgt ccaccaagga gcagatttca cggaactcga aggcgctgga agagaaatat      480

gtggccgagc tgcagctgga gaggctcaag aaggatggcg aagtccgggg gagcatcaat      540

cgcttcaaga cctcggacta cgtgaaggaa gccaaacagc tgttgaaggt gcagaaggcc      600

taccaccaac tggaccaatc attcattgac acttacatcg atctgcttga aaccaggcgc      660

acctactacg agggtcctgg agaaggcagc cctttcggat ggaaggacat caaggagtgg      720

tatgagatgc tgatgggtca ttgcacctac tttccggaag aactgcgctc agtgaagtac      780

gcgtacaacg ctgacctcta caacgctctc aacgatctga acaacctcgt gatcacccgg      840

gacgagaacg aaaagctgga gtactacgaa aagttccaga ttatcgaaaa cgtgttcaag      900

cagaagaaga agcccaccct gaagcagatt gcaaaggaga tccttgtgaa cgaggaggat      960

attaagggct accgggtcac ctccaccggg aaaccagagt tcactaatct caaggtgtac     1020

catgacatta aggacattac tgcccgcaag gagatcattg aaaacgcgga actgctggac     1080

caaatcgcga agatcctgac catctatcag agctccgagg atatccagga ggaacttact     1140

aacctcaatt ccgagctgac gcaggaagaa atcgagcaaa ttagcaacct gaagggttac     1200

actggaaccc acaacctcag cttgaaagcg attaacctta ttttggatga actttggcac     1260

actaatgaca atcagatcgc cattttcaac cggctgaaac tggtgccgaa gaaggtggac     1320

ctgagccaac agaaggaaat cccgaccacc cttgtggacg atttcatcct gtcacctgtg     1380

gtgaagagga gcttcatcca gtcgatcaag gtcatcaacg ccatcataaa gaagtacggc     1440

cttcccaacg acatcatcat cgaactggcc cgcgagaaga actccaaaga tgcccagaag     1500

atgatcaacg agatgcagaa gcgaaaccgg cagacgaacg aacggatcga ggagatcatc     1560

cggaccaccg ggaaggaaaa cgcgaagtac ctgatcgaga aaatcaagct gcatgatatg     1620

caggaaggga agtgtctcta ctccctggag gccattccgc tggaggattt gctgaacaac     1680

cctttcaact acgaagtcga tcatatcatt cctcgctccg tgtccttcga taactccttc     1740

aacaataagg tcctcgtgaa gcaggaggag aactcgaaga agggcaacag aaccccgttc     1800

cagtacctct cgtcgtccga ctccaagatc agctacgaaa ctttcaagaa gcacattctg     1860

aacctggcca agggcaaagg gagaattagc aagaccaaga aggaatacct cctggaagag     1920

agagacatca accgcttctc ggtgcaaaag gatttcatca accgcaacct ggtcgatacc     1980

agatacgcca ccaggggact gatgaacctc ctgcggtcct acttccgggt caacaatctg     2040

gacgtgaagg tcaaatccat caacgggggc tttacttctt tcctgcgccg gaagtggaag     2100

ttcaagaagg aacggaacaa gggatacaag caccacgctg aagatgccct gattattgcc     2160

aacgccgact tcatctttaa ggaatggaaa aagctggaca aggctaagaa ggtcatggag     2220

aaccagatgt tcgaagaaaa gcaggccgag tccatgcccg aaatcgaaac cgagcaggaa     2280

tacaaggaga tcttcatcac accgcaccaa atcaagcaca tcaaggactt caaggattac     2340

aagtacagcc accgggtgga caagaagcct aacagagagc ttatcaacga caccctgtac     2400

tccacgcgca aggacgacaa gggaaacaca ttgatcgtga acaacctgaa cggactgtat     2460

gacaaggaca atgacaaact gaagaagctg atcaacaaat cgccggaaaa gctcctgatg     2520

taccatcacg accctcaaac ctaccagaaa ctgaagctca tcatggagca gtacggcgac     2580

gaaaagaatc ccctgtacaa atactacgag gagactggaa attacctgac taagtactcc     2640

aagaaggata acggccccgt gatcaagaag attaagtact acggaaacaa actgaacgca     2700

catctcgaca tcaccgatga ttatccaaac tcccgcaaca aagtcgtgaa gctctccctc     2760

aaaccgtacc gcttcgacgt gtacctggat aatggggtgt acaagttcgt gaccgtgaag     2820

aacctggacg tcattaagaa ggaaaactac tacgaagtga actcaaagtg ctacgaggaa     2880

gccaagaagc tcaagaagat cagcaaccag gccgagttca tcgcatcgtt ttacaacaat     2940

gacctcatta agattaatgg agaactgtac agagtgatcg gcgtgaacaa cgacctcctg     3000

aaccggattg aagtgaacat gatcgatatt acctaccggg agtatctgga gaacatgaac     3060

gacaagcgcc caccgagaat catcaaaact attgcctcca agacccaatc cattaagaaa     3120

tactccaccg acatcctggg caacctgtac gaggtcaagt cgaagaagca cccccagatt     3180

atcaagaagg gaaagcttgc cccaaagaag aagcggaagg tctaa                     3225


<210>  53
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Intron

<400>  53
gtaagtatca aggttacaag acagcttgtc gagacagaga agactcttgc gtttctgata       60

ggcacctatt ggtcttactg acatccactt tgcctttctc tccacag                    107


<210>  54
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Intron

<400>  54
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  55
<211>  70
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(70)
<223>  BCL11A intron 2

<400>  55
gtatgtctac atttctctta ggtaaacatc taaggcattt cgagaacaca gaaaaggttt       60

tgagtttgag                                                              70


<210>  56
<211>  45
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Retinoblastoma intron 16

<400>  56
gttaatattt cataaatagt tacttttttt ttcattttta ggaag                       45


<210>  57
<211>  3359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: SaCas9 with intron containing R32BS

<400>  57
atggccccaa agaagaagcg gaaggtcgga tccggaaagc ggaactatat cctgggactg       60

gacatcggaa ttacctccgt gggatacggc atcatcgatt acgagactag ggacgtgatt      120

gacgccggcg tgagactctt taaggaggcc aacgtggaaa acaacgaagg tcgcagatcc      180

aagcggggtg caagacgcct gaagcgccgg aggagacatc ggatacagcg cgtgaagaag      240

ctccttttcg actacaacct cctcactgac cactcggaat tgtccggtat caacccctac      300

gaagcccgcg tgaaaggcct gagccagaag ctgtccgaag aggagtttag cgcagccctg      360

ctgcacctgg ctaagcgaag gggggtgcac aacgtgaacg aggtggagga ggacactggc      420

aacgaactgt ccaccaagga gcagatttca cggaactcga aggcgctgga agagaaatat      480

gtggccgagc tgcagctgga gaggctcaag aaggatggcg aagtccgggg gagcatcaat      540

cgcttcaaga cctcggacta cgtgaaggaa gccaaacagc tgttgaaggt gcagaaggcc      600

taccaccaac tggaccaatc attcattgac acttacatcg atctgcttga aaccaggcgc      660

acctactacg agggtcctgg agaaggcagc cctttcggat ggaaggacat caaggagtgg      720

tatgagatgc tgatgggtca ttgcacctac tttccggaag aactgcgctc agtgaagtac      780

gcgtacaacg ctgacctcta caacgctctc aacgatctga acaacctcgt gatcacccgg      840

gacgagaacg aaaagctgga gtactacgaa aagttccaga ttatcgaaaa cgtgttcaag      900

cagaagaaga agcccaccct gaagcagatt gcaaaggaga tccttgtgaa cgaggaggat      960

attaagggct accgggtcac ctccaccggg aaaccagagt tcactaatct caaggtgtac     1020

catgacatta aggacattac tgcccgcaag gagatcattg aaaacgcgga actgctggac     1080

caaatcgcga agatcctgac catctatcag agctccgagg atatccagga ggaacttact     1140

aacctcaatt ccgagctgac gcaggaagaa atcgagcaaa ttagcaacct gaagggttac     1200

actggaaccc acaacctcag cttgaaagcg attaacctta ttttggatga actttggcac     1260

actaatgaca atcagatcgc cattttcaac cggctgaaac tggtgccgaa gaaggtggac     1320

ctgagccaac agaaggaaat cccgaccacc cttgtggacg atttcatcct gtcacctgtg     1380

gtgaagagga gcttcatcca gtcgatcaag gtcatcaacg ccatcataaa gaagtacggc     1440

cttcccaacg acatcatcat cgaactggcc cgcgagaaga actccaaaga tgcccagaag     1500

atgatcaacg agatgcagaa gcgaaaccgg cagacgaacg aacggatcga ggagatcatc     1560

cggaccaccg ggaaggaaaa cgcgaagtac ctgatcgaga aaatcaagct gcatgatatg     1620

caggaaggga agtgtctcta ctccctggag gccattccgc tggaggattt gctgaacaac     1680

cctttcaact acgaagtcga tcatatcatt cctcgctccg tgtccttcga taactccttc     1740

aacaataagg tcctcgtgaa gcaggaggag aagtaagtat caaggttaca agacagctat     1800

tctgagtaca gagcatacag agtcttgtcg agacagagaa gactcttgcg tttctgatag     1860

gcacctattg gtcttactga catccacttt gcctttctct ccacagctcg aagaagggca     1920

acagaacccc gttccagtac ctctcgtcgt ccgactccaa gatcagctac gaaactttca     1980

agaagcacat tctgaacctg gccaagggca aagggagaat tagcaagacc aagaaggaat     2040

acctcctgga agagagagac atcaaccgct tctcggtgca aaaggatttc atcaaccgca     2100

acctggtcga taccagatac gccaccaggg gactgatgaa cctcctgcgg tcctacttcc     2160

gggtcaacaa tctggacgtg aaggtcaaat ccatcaacgg gggctttact tctttcctgc     2220

gccggaagtg gaagttcaag aaggaacgga acaagggata caagcaccac gctgaagatg     2280

ccctgattat tgccaacgcc gacttcatct ttaaggaatg gaaaaagctg gacaaggcta     2340

agaaggtcat ggagaaccag atgttcgaag aaaagcaggc cgagtccatg cccgaaatcg     2400

aaaccgagca ggaatacaag gagatcttca tcacaccgca ccaaatcaag cacatcaagg     2460

acttcaagga ttacaagtac agccaccggg tggacaagaa gcctaacaga gagcttatca     2520

acgacaccct gtactccacg cgcaaggacg acaagggaaa cacattgatc gtgaacaacc     2580

tgaacggact gtatgacaag gacaatgaca aactgaagaa gctgatcaac aaatcgccgg     2640

aaaagctcct gatgtaccat cacgaccctc aaacctacca gaaactgaag ctcatcatgg     2700

agcagtacgg cgacgaaaag aatcccctgt acaaatacta cgaggagact ggaaattacc     2760

tgactaagta ctccaagaag gataacggcc ccgtgatcaa gaagattaag tactacggaa     2820

acaaactgaa cgcacatctc gacatcaccg atgattatcc aaactcccgc aacaaagtcg     2880

tgaagctctc cctcaaaccg taccgcttcg acgtgtacct ggataatggg gtgtacaagt     2940

tcgtgaccgt gaagaacctg gacgtcatta agaaggaaaa ctactacgaa gtgaactcaa     3000

agtgctacga ggaagccaag aagctcaaga agatcagcaa ccaggccgag ttcatcgcat     3060

cgttttacaa caatgacctc attaagatta atggagaact gtacagagtg atcggcgtga     3120

acaacgacct cctgaaccgg attgaagtga acatgatcga tattacctac cgggagtatc     3180

tggagaacat gaacgacaag cgcccaccga gaatcatcaa aactattgcc tccaagaccc     3240

aatccattaa gaaatactcc accgacatcc tgggcaacct gtacgaggtc aagtcgaaga     3300

agcaccccca gattatcaag aagggaaagc ttgccccaaa gaagaagcgg aaggtctaa      3359


<210>  58
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Poly A

<400>  58
aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtg                   49


<210>  59
<211>  4860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-212

<400>  59
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtgtg gaaagtcccc aggctcccca gcaggcagaa      180

gtatgcaaag catgcatctc aattagtcag caaccacgtt acataactta cggtaaatgg      240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      600

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      660

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      720

agctcgttta gtgaaccgtc accggtgtat tgcttgtact actcactgaa tgccaccatg      780

gccccaaaga agaagcggaa ggtcggatcc ggaaagcgga actatatcct gggactggac      840

atcggaatta cctccgtggg atacggcatc atcgattacg agactaggga cgtgattgac      900

gccggcgtga gactctttaa ggaggccaac gtggaaaaca acgaaggtcg cagatccaag      960

cggggtgcaa gacgcctgaa gcgccggagg agacatcgga tacagcgcgt gaagaagctc     1020

cttttcgact acaacctcct cactgaccac tcggaattgt ccggtatcaa cccctacgaa     1080

gcccgcgtga aaggcctgag ccagaagctg tccgaagagg agtttagcgc agccctgctg     1140

cacctggcta agcgaagggg ggtgcacaac gtgaacgagg tggaggagga cactggcaac     1200

gaactgtcca ccaaggagca gatttcacgg aactcgaagg cgctggaaga gaaatatgtg     1260

gccgagctgc agctggagag gctcaagaag gatggcgaag tccgggggag catcaatcgc     1320

ttcaagacct cggactacgt gaaggaagcc aaacagctgt tgaaggtgca gaaggcctac     1380

caccaactgg accaatcatt cattgacact tacatcgatc tgcttgaaac caggcgcacc     1440

tactacgagg gtcctggaga aggcagccct ttcggatgga aggacatcaa ggagtggtat     1500

gagatgctga tgggtcattg cacctacttt ccggaagaac tgcgctcagt gaagtacgcg     1560

tacaacgctg acctctacaa cgctctcaac gatctgaaca acctcgtgat cacccgggac     1620

gagaacgaaa agctggagta ctacgaaaag ttccagatta tcgaaaacgt gttcaagcag     1680

aagaagaagc ccaccctgaa gcagattgca aaggagatcc ttgtgaacga ggaggatatt     1740

aagggctacc gggtcacctc caccgggaaa ccagagttca ctaatctcaa ggtgtaccat     1800

gacattaagg acattactgc ccgcaaggag atcattgaaa acgcggaact gctggaccaa     1860

atcgcgaaga tcctgaccat ctatcagagc tccgaggata tccaggagga acttactaac     1920

ctcaattccg agctgacgca ggaagaaatc gagcaaatta gcaacctgaa gggttacact     1980

ggaacccaca acctcagctt gaaagcgatt aaccttattt tggatgaact ttggcacact     2040

aatgacaatc agatcgccat tttcaaccgg ctgaaactgg tgccgaagaa ggtggacctg     2100

agccaacaga aggaaatccc gaccaccctt gtggacgatt tcatcctgtc acctgtggtg     2160

aagaggagct tcatccagtc gatcaaggtc atcaacgcca tcataaagaa gtacggcctt     2220

cccaacgaca tcatcatcga actggcccgc gagaagaact ccaaagatgc ccagaagatg     2280

atcaacgaga tgcagaagcg aaaccggcag acgaacgaac ggatcgagga gatcatccgg     2340

accaccggga aggaaaacgc gaagtacctg atcgagaaaa tcaagctgca tgatatgcag     2400

gaagggaagt gtctctactc cctggaggcc attccgctgg aggatttgct gaacaaccct     2460

ttcaactacg aagtcgatca tatcattcct cgctccgtgt ccttcgataa ctccttcaac     2520

aataaggtcc tcgtgaagca ggaggagaag taagtatcaa ggttacaaga caggtgtatt     2580

gcttgtacta ctcactgaat cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2640

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2700

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2760

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2820

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2880

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2940

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     3000

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     3060

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     3120

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     3180

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     3240

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3300

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3360

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3420

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3480

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3540

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3600

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3660

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3720

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3780

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3840

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3900

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3960

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     4020

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     4080

acccccagat tatcaagaag ggaaagcttg ccccaaagaa gaagcggaag gtcggtacta     4140

gtgagggcag gggaagtctg ctaacatgcg gggacgtgga ggaaaatccc ggccccatgg     4200

ctaagacttc cgaacagagg gtgaacattg ctacactgct gacagaaaat aagaagaaaa     4260

tcgtggataa ggcttcccag gatctgtggc ggagacaccc agacctgatc gcaccaggag     4320

gaattgcttt ctctcagagg gaccgcgctc tgtgcctgcg agattacggc tggttcctgc     4380

atctgatcac cttttgtctg ctggccggag ataagggccc catcgagtct attgggctga     4440

tcagtattcg agaaatgtat aactcactgg gagtgcccgt ccctgcaatg atggagagca     4500

ttagatgcct gaaagaagcc agcctgtccc tgctggacga agaggacgcc aacgagaccg     4560

caccctactt tgattacatt attaaggcta tgagctaagc gctgtgttat tacttgctac     4620

tgcagagagt aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtgg     4680

taaccacgtg cggaccgagg ctgcagcgtc gtcctcccta ggaaccccta gtgatggagt     4740

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4800

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg     4860


<210>  60
<211>  4833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-214

<400>  60
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtgtg gaaagtcccc aggctcccca gcaggcagaa      180

gtatgcaaag catgcatctc aattagtcag caaccacgtt acataactta cggtaaatgg      240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      600

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      660

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      720

agctcgttta gtgaaccgtc accggtgtat tgcttgtact actcactgaa tgccaccatg      780

gccccaaaga agaagcggaa ggtcggatcc ggaaagcgga actatatcct gggactggac      840

atcggaatta cctccgtggg atacggcatc atcgattacg agactaggga cgtgattgac      900

gccggcgtga gactctttaa ggaggccaac gtggaaaaca acgaaggtcg cagatccaag      960

cggggtgcaa gacgcctgaa gcgccggagg agacatcgga tacagcgcgt gaagaagctc     1020

cttttcgact acaacctcct cactgaccac tcggaattgt ccggtatcaa cccctacgaa     1080

gcccgcgtga aaggcctgag ccagaagctg tccgaagagg agtttagcgc agccctgctg     1140

cacctggcta agcgaagggg ggtgcacaac gtgaacgagg tggaggagga cactggcaac     1200

gaactgtcca ccaaggagca gatttcacgg aactcgaagg cgctggaaga gaaatatgtg     1260

gccgagctgc agctggagag gctcaagaag gatggcgaag tccgggggag catcaatcgc     1320

ttcaagacct cggactacgt gaaggaagcc aaacagctgt tgaaggtgca gaaggcctac     1380

caccaactgg accaatcatt cattgacact tacatcgatc tgcttgaaac caggcgcacc     1440

tactacgagg gtcctggaga aggcagccct ttcggatgga aggacatcaa ggagtggtat     1500

gagatgctga tgggtcattg cacctacttt ccggaagaac tgcgctcagt gaagtacgcg     1560

tacaacgctg acctctacaa cgctctcaac gatctgaaca acctcgtgat cacccgggac     1620

gagaacgaaa agctggagta ctacgaaaag ttccagatta tcgaaaacgt gttcaagcag     1680

aagaagaagc ccaccctgaa gcagattgca aaggagatcc ttgtgaacga ggaggatatt     1740

aagggctacc gggtcacctc caccgggaaa ccagagttca ctaatctcaa ggtgtaccat     1800

gacattaagg acattactgc ccgcaaggag atcattgaaa acgcggaact gctggaccaa     1860

atcgcgaaga tcctgaccat ctatcagagc tccgaggata tccaggagga acttactaac     1920

ctcaattccg agctgacgca ggaagaaatc gagcaaatta gcaacctgaa gggttacact     1980

ggaacccaca acctcagctt gaaagcgatt aaccttattt tggatgaact ttggcacact     2040

aatgacaatc agatcgccat tttcaaccgg ctgaaactgg tgccgaagaa ggtggacctg     2100

agccaacaga aggaaatccc gaccaccctt gtggacgatt tcatcctgtc acctgtggtg     2160

aagaggagct tcatccagtc gatcaaggtc atcaacgcca tcataaagaa gtacggcctt     2220

cccaacgaca tcatcatcga actggcccgc gagaagaact ccaaagatgc ccagaagatg     2280

atcaacgaga tgcagaagcg aaaccggcag acgaacgaac ggatcgagga gatcatccgg     2340

accaccggga aggaaaacgc gaagtacctg atcgagaaaa tcaagctgca tgatatgcag     2400

gaagggaagt gtctctactc cctggaggcc attccgctgg aggatttgct gaacaaccct     2460

ttcaactacg aagtcgatca tatcattcct cgctccgtgt ccttcgataa ctccttcaac     2520

aataaggtcc tcgtgaagca ggaggagaag taagtatcaa ggttacaaga caggtgttat     2580

tacttgctac tgcagagagt cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2640

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2700

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2760

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2820

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2880

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2940

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     3000

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     3060

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     3120

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     3180

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     3240

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3300

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3360

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3420

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3480

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3540

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3600

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3660

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3720

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3780

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3840

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3900

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3960

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     4020

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     4080

acccccagat tatcaagaag ggaaagcttg ccccaaagaa gaagcggaag gtcggtacta     4140

gtgagggcag gggaagtctg ctaacatgcg gggacgtgga ggaaaatccc ggccccatgg     4200

ctaagacttc cgaacagagg gtgaacattg ctacactgct gacagaaaat aagaagaaaa     4260

tcgtggataa ggcttcccag gatctgtggc ggagacaccc agacctgatc gcaccaggag     4320

gaattgcttt ctctcagagg gaccgcgctc tgtgcctgcg agattacggc tggttcctgc     4380

atctgatcac cttttgtctg ctggccggag ataagggccc catcgagtct attgggctga     4440

tcagtattcg agaaatgtat aactcactgg gagtgcccgt ccctgcaatg atggagagca     4500

ttagatgcct gaaagaagcc agcctgtccc tgctggacga agaggacgcc aacgagaccg     4560

caccctactt tgattacatt attaaggcta tgagctaagc gctaataaaa tatctttatt     4620

ttcattacat ctgtgtgttg gttttttgtg tggtaaccac gtgcggaccg aggctgcagc     4680

gtcgtcctcc ctaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4740

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4800

cagtgagcga gcgagcgcgc agctgcctgc agg                                  4833


<210>  61
<211>  4972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-217

<400>  61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtgtg gaaagtcccc aggctcccca gcaggcagaa      180

gtatgcaaag catgcatctc aattagtcag caaccacgtt acataactta cggtaaatgg      240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      600

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      660

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      720

agctcgttta gtgaaccgtc accggtgtat tgcttgtact actcactgaa tgccaccatg      780

gccccaaaga agaagcggaa ggtcggatcc ggaaagcgga actatatcct gggactgggt      840

aagtgtattg cttgtactac tcactgaatc accatcgggc gcgaaggggg agacctgtag      900

tcagagcccc cgggcagcac acactgacat ccactccctt cctattgttt cagacatcgg      960

aattacctcc gtgggatacg gcatcatcga ttacgagact agggacgtga ttgacgccgg     1020

cgtgagactc tttaaggagg ccaacgtgga aaacaacgaa ggtcgcagat ccaagcgggg     1080

tgcaagacgc ctgaagcgcc ggaggagaca tcggatacag cgcgtgaaga agctcctttt     1140

cgactacaac ctcctcactg accactcgga attgtccggt atcaacccct acgaagcccg     1200

cgtgaaaggc ctgagccaga agctgtccga agaggagttt agcgcagccc tgctgcacct     1260

ggctaagcga aggggggtgc acaacgtgaa cgaggtggag gaggacactg gcaacgaact     1320

gtccaccaag gagcagattt cacggaactc gaaggcgctg gaagagaaat atgtggccga     1380

gctgcagctg gagaggctca agaaggatgg cgaagtccgg gggagcatca atcgcttcaa     1440

gacctcggac tacgtgaagg aagccaaaca gctgttgaag gtgcagaagg cctaccacca     1500

actggaccaa tcattcattg acacttacat cgatctgctt gaaaccaggc gcacctacta     1560

cgagggtcct ggagaaggca gccctttcgg atggaaggac atcaaggagt ggtatgagat     1620

gctgatgggt cattgcacct actttccgga agaactgcgc tcagtgaagt acgcgtacaa     1680

cgctgacctc tacaacgctc tcaacgatct gaacaacctc gtgatcaccc gggacgagaa     1740

cgaaaagctg gagtactacg aaaagttcca gattatcgaa aacgtgttca agcagaagaa     1800

gaagcccacc ctgaagcaga ttgcaaagga gatccttgtg aacgaggagg atattaaggg     1860

ctaccgggtc acctccaccg ggaaaccaga gttcactaat ctcaaggtgt accatgacat     1920

taaggacatt actgcccgca aggagatcat tgaaaacgcg gaactgctgg accaaatcgc     1980

gaagatcctg accatctatc agagctccga ggatatccag gaggaactta ctaacctcaa     2040

ttccgagctg acgcaggaag aaatcgagca aattagcaac ctgaagggtt acactggaac     2100

ccacaacctc agcttgaaag cgattaacct tattttggat gaactttggc acactaatga     2160

caatcagatc gccattttca accggctgaa actggtgccg aagaaggtgg acctgagcca     2220

acagaaggaa atcccgacca cccttgtgga cgatttcatc ctgtcacctg tggtgaagag     2280

gagcttcatc cagtcgatca aggtcatcaa cgccatcata aagaagtacg gccttcccaa     2340

cgacatcatc atcgaactgg cccgcgagaa gaactccaaa gatgcccaga agatgatcaa     2400

cgagatgcag aagcgaaacc ggcagacgaa cgaacggatc gaggagatca tccggaccac     2460

cgggaaggaa aacgcgaagt acctgatcga gaaaatcaag ctgcatgata tgcaggaagg     2520

gaagtgtctc tactccctgg aggccattcc gctggaggat ttgctgaaca accctttcaa     2580

ctacgaagtc gatcatatca ttcctcgctc cgtgtccttc gataactcct tcaacaataa     2640

ggtcctcgtg aagcaggagg agaagtaagt atcaaggtta caagacaggt gttattactt     2700

gctactgcag agagtcttgt cgagacagag aagactcttg cgtttctgat aggcacctat     2760

tggtcttact gacatccact ttgcctttct ctccacagct cgaagaaggg caacagaacc     2820

ccgttccagt acctctcgtc gtccgactcc aagatcagct acgaaacttt caagaagcac     2880

attctgaacc tggccaaggg caaagggaga attagcaaga ccaagaagga atacctcctg     2940

gaagagagag acatcaaccg cttctcggtg caaaaggatt tcatcaaccg caacctggtc     3000

gataccagat acgccaccag gggactgatg aacctcctgc ggtcctactt ccgggtcaac     3060

aatctggacg tgaaggtcaa atccatcaac gggggcttta cttctttcct gcgccggaag     3120

tggaagttca agaaggaacg gaacaaggga tacaagcacc acgctgaaga tgccctgatt     3180

attgccaacg ccgacttcat ctttaaggaa tggaaaaagc tggacaaggc taagaaggtc     3240

atggagaacc agatgttcga agaaaagcag gccgagtcca tgcccgaaat cgaaaccgag     3300

caggaataca aggagatctt catcacaccg caccaaatca agcacatcaa ggacttcaag     3360

gattacaagt acagccaccg ggtggacaag aagcctaaca gagagcttat caacgacacc     3420

ctgtactcca cgcgcaagga cgacaaggga aacacattga tcgtgaacaa cctgaacgga     3480

ctgtatgaca aggacaatga caaactgaag aagctgatca acaaatcgcc ggaaaagctc     3540

ctgatgtacc atcacgaccc tcaaacctac cagaaactga agctcatcat ggagcagtac     3600

ggcgacgaaa agaatcccct gtacaaatac tacgaggaga ctggaaatta cctgactaag     3660

tactccaaga aggataacgg ccccgtgatc aagaagatta agtactacgg aaacaaactg     3720

aacgcacatc tcgacatcac cgatgattat ccaaactccc gcaacaaagt cgtgaagctc     3780

tccctcaaac cgtaccgctt cgacgtgtac ctggataatg gggtgtacaa gttcgtgacc     3840

gtgaagaacc tggacgtcat taagaaggaa aactactacg aagtgaactc aaagtgctac     3900

gaggaagcca agaagctcaa gaagatcagc aaccaggccg agttcatcgc atcgttttac     3960

aacaatgacc tcattaagat taatggagaa ctgtacagag tgatcggcgt gaacaacgac     4020

ctcctgaacc ggattgaagt gaacatgatc gatattacct accgggagta tctggagaac     4080

atgaacgaca agcgcccacc gagaatcatc aaaactattg cctccaagac ccaatccatt     4140

aagaaatact ccaccgacat cctgggcaac ctgtacgagg tcaagtcgaa gaagcacccc     4200

cagattatca agaagggaaa gcttgcccca aagaagaagc ggaaggtcgg tactagtgag     4260

ggcaggggaa gtctgctaac atgcggggac gtggaggaaa atcccggccc cgctaagact     4320

tccgaacaga gggtgaacat tgctacactg ctgacagaaa ataagaagaa aatcgtggat     4380

aaggcttccc aggatctgtg gcggagacac ccagacctga tcgcaccagg aggaattgct     4440

ttctctcaga gggaccgcgc tctgtgcctg cgagattacg gctggttcct gcatctgatc     4500

accttttgtc tgctggccgg agataagggc cccatcgagt ctattgggct gatcagtatt     4560

cgagaaatgt ataactcact gggagtgccc gtccctgcaa tgatggagag cattagatgc     4620

ctgaaagaag ccagcctgtc cctgctggac gaagaggacg ccaacgagac cgcaccctac     4680

tttgattaca ttattaaggc tatgagctaa gcgctgtgtt attacttgct actgcagaga     4740

gtaataaaat atctttattt tcattacatc tgtgtgttgg ttttttgtgt ggtaaccacg     4800

tgcggaccga ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact     4860

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4920

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca gg             4972


<210>  62
<211>  4952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-506

<400>  62
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgcttaga ggtcttctac atacagttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggtgt ggaaagtccc caggctcccc      540

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccacgt tacataactt      600

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg      660

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      720

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      780

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg      840

gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg      900

ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc      960

caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa     1020

tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc     1080

tatataagca gagctcgttt agtgaaccgt caccggtgcc accatggccc caaagaagaa     1140

gcggaaggtc ggatccggaa agcggaacta tatcctggga ctggacatcg gaattacctc     1200

cgtgggatac ggcatcatcg attacgagac tagggacgtg attgacgccg gcgtgagact     1260

ctttaaggag gccaacgtgg aaaacaacga aggtcgcaga tccaagcggg gtgcaagacg     1320

cctgaagcgc cggaggagac atcggataca gcgcgtgaag aagctccttt tcgactacaa     1380

cctcctcact gaccactcgg aattgtccgg tatcaacccc tacgaagccc gcgtgaaagg     1440

cctgagccag aagctgtccg aagaggagtt tagcgcagcc ctgctgcacc tggctaagcg     1500

aaggggggtg cacaacgtga acgaggtgga ggaggacact ggcaacgaac tgtccaccaa     1560

ggagcagatt tcacggaact cgaaggcgct ggaagagaaa tatgtggccg agctgcagct     1620

ggagaggctc aagaaggatg gcgaagtccg ggggagcatc aatcgcttca agacctcgga     1680

ctacgtgaag gaagccaaac agctgttgaa ggtgcagaag gcctaccacc aactggacca     1740

atcattcatt gacacttaca tcgatctgct tgaaaccagg cgcacctact acgagggtcc     1800

tggagaaggc agccctttcg gatggaagga catcaaggag tggtatgaga tgctgatggg     1860

tcattgcacc tactttccgg aagaactgcg ctcagtgaag tacgcgtaca acgctgacct     1920

ctacaacgct ctcaacgatc tgaacaacct cgtgatcacc cgggacgaga acgaaaagct     1980

ggagtactac gaaaagttcc agattatcga aaacgtgttc aagcagaaga agaagcccac     2040

cctgaagcag attgcaaagg agatccttgt gaacgaggag gatattaagg gctaccgggt     2100

cacctccacc gggaaaccag agttcactaa tctcaaggtg taccatgaca ttaaggacat     2160

tactgcccgc aaggagatca ttgaaaacgc ggaactgctg gaccaaatcg cgaagatcct     2220

gaccatctat cagagctccg aggatatcca ggaggaactt actaacctca attccgagct     2280

gacgcaggaa gaaatcgagc aaattagcaa cctgaagggt tacactggaa cccacaacct     2340

cagcttgaaa gcgattaacc ttattttgga tgaactttgg cacactaatg acaatcagat     2400

cgccattttc aaccggctga aactggtgcc gaagaaggtg gacctgagcc aacagaagga     2460

aatcccgacc acccttgtgg acgatttcat cctgtcacct gtggtgaaga ggagcttcat     2520

ccagtcgatc aaggtcatca acgccatcat aaagaagtac ggccttccca acgacatcat     2580

catcgaactg gcccgcgaga agaactccaa agatgcccag aagatgatca acgagatgca     2640

gaagcgaaac cggcagacga acgaacggat cgaggagatc atccggacca ccgggaagga     2700

aaacgcgaag tacctgatcg agaaaatcaa gctgcatgat atgcaggaag ggaagtgtct     2760

ctactccctg gaggccattc cgctggagga tttgctgaac aaccctttca actacgaagt     2820

cgatcatatc attcctcgct ccgtgtcctt cgataactcc ttcaacaata aggtcctcgt     2880

gaagcaggag gagaactcga agaagggcaa cagaaccccg ttccagtacc tctcgtcgtc     2940

cgactccaag atcagctacg aaactttcaa gaagcacatt ctgaacctgg ccaagggcaa     3000

agggagaatt agcaagacca agaaggaata cctcctggaa gagagagaca tcaaccgctt     3060

ctcggtgcaa aaggatttca tcaaccgcaa cctggtcgat accagatacg ccaccagggg     3120

actgatgaac ctcctgcggt cctacttccg ggtcaacaat ctggacgtga aggtcaaatc     3180

catcaacggg ggctttactt ctttcctgcg ccggaagtgg aagttcaaga aggaacggaa     3240

caagggatac aagcaccacg ctgaagatgc cctgattatt gccaacgccg acttcatctt     3300

taaggaatgg aaaaagctgg acaaggctaa gaaggtcatg gagaaccaga tgttcgaaga     3360

aaagcaggcc gagtccatgc ccgaaatcga aaccgagcag gaatacaagg agatcttcat     3420

cacaccgcac caaatcaagc acatcaagga cttcaaggat tacaagtaca gccaccgggt     3480

ggacaagaag cctaacagag agcttatcaa cgacaccctg tactccacgc gcaaggacga     3540

caagggaaac acattgatcg tgaacaacct gaacggactg tatgacaagg acaatgacaa     3600

actgaagaag ctgatcaaca aatcgccgga aaagctcctg atgtaccatc acgaccctca     3660

aacctaccag aaactgaagc tcatcatgga gcagtacggc gacgaaaaga atcccctgta     3720

caaatactac gaggagactg gaaattacct gactaagtac tccaagaagg ataacggccc     3780

cgtgatcaag aagattaagt actacggaaa caaactgaac gcacatctcg acatcaccga     3840

tgattatcca aactcccgca acaaagtcgt gaagctctcc ctcaaaccgt accgcttcga     3900

cgtgtacctg gataatgggg tgtacaagtt cgtgaccgtg aagaacctgg acgtcattaa     3960

gaaggaaaac tactacgaag tgaactcaaa gtgctacgag gaagccaaga agctcaagaa     4020

gatcagcaac caggccgagt tcatcgcatc gttttacaac aatgacctca ttaagattaa     4080

tggagaactg tacagagtga tcggcgtgaa caacgacctc ctgaaccgga ttgaagtgaa     4140

catgatcgat attacctacc gggagtatct ggagaacatg aacgacaagc gcccaccgag     4200

aatcatcaaa actattgcct ccaagaccca atccattaag aaatactcca ccgacatcct     4260

gggcaacctg tacgaggtca agtcgaagaa gcacccccag attatcaaga agggaaagct     4320

tgccccaaag aagaagcgga aggtctaagg tactagtaat aaaatatctt tattttcatt     4380

acatctgtgt gttggttttt tgtgtgagcg ctgagggcct atttcccatg attccttcat     4440

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     4500

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     4560

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     4620

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgctattctg agtacagagc     4680

atagtttaag tactctgtgc tggaaacagc acagaatcta cttaaacaag gcaaaatgcc     4740

gtgtttatct cgtcaacttg ttggcgagat ttttttggta accggaccga ggctgcagcg     4800

tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     4860

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     4920

agtgagcgag cgagcgcgca gctgcctgca gg                                   4952


<210>  63
<211>  4956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-507

<400>  63
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgttctga ctgtaagtac actatgttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggtgt ggaaagtccc caggctcccc      540

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccacgt tacataactt      600

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg      660

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      720

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      780

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg      840

gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg      900

ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc      960

caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa     1020

tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc     1080

tatataagca gagctcgttt agtgaaccgt caccggtgcc accatggccc caaagaagaa     1140

gcggaaggtc ggatccggaa agcggaacta tatcctggga ctggacatcg gaattacctc     1200

cgtgggatac ggcatcatcg attacgagac tagggacgtg attgacgccg gcgtgagact     1260

ctttaaggag gccaacgtgg aaaacaacga aggtcgcaga tccaagcggg gtgcaagacg     1320

cctgaagcgc cggaggagac atcggataca gcgcgtgaag aagctccttt tcgactacaa     1380

cctcctcact gaccactcgg aattgtccgg tatcaacccc tacgaagccc gcgtgaaagg     1440

cctgagccag aagctgtccg aagaggagtt tagcgcagcc ctgctgcacc tggctaagcg     1500

aaggggggtg cacaacgtga acgaggtgga ggaggacact ggcaacgaac tgtccaccaa     1560

ggagcagatt tcacggaact cgaaggcgct ggaagagaaa tatgtggccg agctgcagct     1620

ggagaggctc aagaaggatg gcgaagtccg ggggagcatc aatcgcttca agacctcgga     1680

ctacgtgaag gaagccaaac agctgttgaa ggtgcagaag gcctaccacc aactggacca     1740

atcattcatt gacacttaca tcgatctgct tgaaaccagg cgcacctact acgagggtcc     1800

tggagaaggc agccctttcg gatggaagga catcaaggag tggtatgaga tgctgatggg     1860

tcattgcacc tactttccgg aagaactgcg ctcagtgaag tacgcgtaca acgctgacct     1920

ctacaacgct ctcaacgatc tgaacaacct cgtgatcacc cgggacgaga acgaaaagct     1980

ggagtactac gaaaagttcc agattatcga aaacgtgttc aagcagaaga agaagcccac     2040

cctgaagcag attgcaaagg agatccttgt gaacgaggag gatattaagg gctaccgggt     2100

cacctccacc gggaaaccag agttcactaa tctcaaggtg taccatgaca ttaaggacat     2160

tactgcccgc aaggagatca ttgaaaacgc ggaactgctg gaccaaatcg cgaagatcct     2220

gaccatctat cagagctccg aggatatcca ggaggaactt actaacctca attccgagct     2280

gacgcaggaa gaaatcgagc aaattagcaa cctgaagggt tacactggaa cccacaacct     2340

cagcttgaaa gcgattaacc ttattttgga tgaactttgg cacactaatg acaatcagat     2400

cgccattttc aaccggctga aactggtgcc gaagaaggtg gacctgagcc aacagaagga     2460

aatcccgacc acccttgtgg acgatttcat cctgtcacct gtggtgaaga ggagcttcat     2520

ccagtcgatc aaggtcatca acgccatcat aaagaagtac ggccttccca acgacatcat     2580

catcgaactg gcccgcgaga agaactccaa agatgcccag aagatgatca acgagatgca     2640

gaagcgaaac cggcagacga acgaacggat cgaggagatc atccggacca ccgggaagga     2700

aaacgcgaag tacctgatcg agaaaatcaa gctgcatgat atgcaggaag ggaagtgtct     2760

ctactccctg gaggccattc cgctggagga tttgctgaac aaccctttca actacgaagt     2820

cgatcatatc attcctcgct ccgtgtcctt cgataactcc ttcaacaata aggtcctcgt     2880

gaagcaggag gagaactcga agaagggcaa cagaaccccg ttccagtacc tctcgtcgtc     2940

cgactccaag atcagctacg aaactttcaa gaagcacatt ctgaacctgg ccaagggcaa     3000

agggagaatt agcaagacca agaaggaata cctcctggaa gagagagaca tcaaccgctt     3060

ctcggtgcaa aaggatttca tcaaccgcaa cctggtcgat accagatacg ccaccagggg     3120

actgatgaac ctcctgcggt cctacttccg ggtcaacaat ctggacgtga aggtcaaatc     3180

catcaacggg ggctttactt ctttcctgcg ccggaagtgg aagttcaaga aggaacggaa     3240

caagggatac aagcaccacg ctgaagatgc cctgattatt gccaacgccg acttcatctt     3300

taaggaatgg aaaaagctgg acaaggctaa gaaggtcatg gagaaccaga tgttcgaaga     3360

aaagcaggcc gagtccatgc ccgaaatcga aaccgagcag gaatacaagg agatcttcat     3420

cacaccgcac caaatcaagc acatcaagga cttcaaggat tacaagtaca gccaccgggt     3480

ggacaagaag cctaacagag agcttatcaa cgacaccctg tactccacgc gcaaggacga     3540

caagggaaac acattgatcg tgaacaacct gaacggactg tatgacaagg acaatgacaa     3600

actgaagaag ctgatcaaca aatcgccgga aaagctcctg atgtaccatc acgaccctca     3660

aacctaccag aaactgaagc tcatcatgga gcagtacggc gacgaaaaga atcccctgta     3720

caaatactac gaggagactg gaaattacct gactaagtac tccaagaagg ataacggccc     3780

cgtgatcaag aagattaagt actacggaaa caaactgaac gcacatctcg acatcaccga     3840

tgattatcca aactcccgca acaaagtcgt gaagctctcc ctcaaaccgt accgcttcga     3900

cgtgtacctg gataatgggg tgtacaagtt cgtgaccgtg aagaacctgg acgtcattaa     3960

gaaggaaaac tactacgaag tgaactcaaa gtgctacgag gaagccaaga agctcaagaa     4020

gatcagcaac caggccgagt tcatcgcatc gttttacaac aatgacctca ttaagattaa     4080

tggagaactg tacagagtga tcggcgtgaa caacgacctc ctgaaccgga ttgaagtgaa     4140

catgatcgat attacctacc gggagtatct ggagaacatg aacgacaagc gcccaccgag     4200

aatcatcaaa actattgcct ccaagaccca atccattaag aaatactcca ccgacatcct     4260

gggcaacctg tacgaggtca agtcgaagaa gcacccccag attatcaaga agggaaagct     4320

tgccccaaag aagaagcgga aggtctaagg tactagtaat aaaatatctt tattttcatt     4380

acatctgtgt gttggttttt tgtgtgagcg ctgagggcct atttcccatg attccttcat     4440

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     4500

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     4560

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     4620

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgctattctg agtacagagc     4680

atagtttaag tactctgtgc tggaaacagc acagaatcta cttaaacaag gcaaaatgcc     4740

gtgtttatct cgtcaacttg ttggcgagat ttttttggta accggaccga ggctgcagcg     4800

tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     4860

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     4920

agtgagcgag cgagcgcgca gagagggagt ggccaa                               4956


<210>  64
<211>  4705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-603

<400>  64
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgactatg attaaatgct tgatagttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggtgt ggaaagtccc caggctcccc      540

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccacgt tacataactt      600

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg      660

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      720

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      780

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg      840

gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg      900

ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc      960

caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa     1020

tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc     1080

tatataagca gagctcgttt agtgaaccgt caccggtgcc accatggccc caaagaagaa     1140

gcggaaggtc ggatccgaga gcgacgagag cggcctgccc gccatggaga tcgagtgccg     1200

catcaccggc accctgaacg gcgtggagtt cgagctggtg ggcggcggag agggcacccc     1260

cgagcagggc cgcatgacca acaagatgaa gagcaccaaa ggcgccctga ccttcagccc     1320

ctacctgctg agccacgtga tgggctacgg cttctaccac ttcggcacct accccagcgg     1380

ctacgagaac cccttcctgc acgccatcaa caacggcggc tacaccaaca cccgcatcga     1440

gaagtacgag gacggcggcg tgctgcacgt gagcttcagc taccgctacg aggccggccg     1500

cgtgatcggc gacttcaagg tgatgggcac cggcttcccc gaggacagcg tgatcttcac     1560

cgacaagatc atccgcagca acgccaccgt ggagcacctg caccccatgg gcgataacga     1620

tctggatggc agcttcaccc gcaccttcag cctgcgcgac ggcggctact acagctccgt     1680

ggtggacagc cacatgcact tcaagagcgc catccacccc agcatcctgc agaacggggg     1740

ccccatgttc gccttccgcc gcgtggagga ggatcacagc aacaccgagc tgggcatcgt     1800

ggagtaccag cacgccttca agaccccgga tgcagatgcc ggtgaagaat aagcgctaat     1860

aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtgagaa aacgccagta     1920

agtgacagag tcacaaatga ctgcacagag tccttggtga acaggcgacc atgcttttca     1980

gctctggaag tcgtgaaaac atacgttccc aaagagtttt gaactgaaaa cttcaccttc     2040

catgcagata tatgcacact ttctgagaag gagagacaaa tcaagaaaca aactgcactt     2100

gttgagcttg tgaaacacaa gcccaaggca acaaaagagc aactgaaagc tgtttgagat     2160

gatttcgcag cttttgtaga gaagtgctgc aaggctgacg ataaggagac ctgctttgcc     2220

gaggagggta aaaaacttgt tgctgcaagt caagctgcct taggcttata acatctacat     2280

ttaaaagact ctcagcctac ctgaagaata agagaaagaa atgaaagatc aaaagcttat     2340

tcatctgttt tctttttcgt tggtgtaaag ccaacaccct gtctaaaaaa cataaatttc     2400

tttaatcatt ttgcctcttt tctctgtgct tcaattaata aaaaatggaa agaatctaat     2460

agagtggtac agcactgtta tttttcaaag atgtgttgct atcctgaaaa ttctgtaggt     2520

tctgtggaag ttccagtgtt ctctcttatt ccacttcggt agaggatttc tagtttctgt     2580

gggctaatta aataaatcac taatactctt ctaagttaag tttgcagaag tttccaagtt     2640

agtgacagat cttaccaaag tccacacgga atgctgcctg agagatctgc ttgaatgtgc     2700

tgatgacagg gcggaccttg ccaagtatat ctgtgaaaat caggattcga tctccagtaa     2760

actgaaggaa tgctgtgaaa aacctctgtt ggaaaaatcc cactgcattg ccgaagtgga     2820

aaatgatgag tgacctgctg acttgcctta cttagctgct gattttgttg aaagtaaggt     2880

gatttgcaaa aacttgactg aggcaaagga tgtcttcctg ggctgatttt tgtatgaata     2940

tgcaagaagg actcctgatt actctgtcgt gctgctgctg agacttgcca agaactatga     3000

aaccacagat ctgaagtgct gtgccgctgc agatcctact gaatgctatg ccaaagtgtt     3060

cgatgaattt aaacctcttg tggaagagcc tcagaattta atcaaacaaa actgtgagct     3120

ttttgagcag cttggagagt acaaattcca gaatgcgcta ttagttcgtt acaccaagaa     3180

agtaccccaa gtgtcaactc caactcttgt agaggtctca agaaacctcg gaaaagtggg     3240

cagcaaatgt tgtaaacatc ctgaagcaaa aagatgaccc tgtgcagaag actatctatc     3300

cgtggtcctg aaccagttat gtgtgttgca tgaggatgtc ttctggcaat ttcatataag     3360

tattttttca aaatgatctc ttctgtcaac cccacgcctt tggcacatga aagtgggtaa     3420

cctttatttc ccttcttttt ctctttagct cggcttattc caggggtgtg tttcgtcgag     3480

atgcacacaa gagtgaggtt gctactcggt ttaaagattt gggagaagaa aatttcaaag     3540

ccttggtgtt gattgccttt gctcagtatc ttcagcagtg tccatttgaa gatactgtaa     3600

aattagtgaa tgaagtaact gaatttgcaa aaaactgtgt agctgtgaag tcagctgaaa     3660

attgtgacaa atcacttcat accctttttg gagacaaatt atgcacagtt gcaactcttc     3720

gtgaaacctt gagtgaatga gctgactgct gtgcaaaaca agaacctgag agatgaaaat     3780

gcttcttgca acacaaagtg aacaacccaa acctcccccg attggtcaga ccagaggttg     3840

atgtgtgatg cactgctttt actgacaatg aagagacatt tttgaaaaaa tacttattga     3900

aaattgccag aagaactcct tactttttga ccccggaact ccttttcttt gctaaaaggt     3960

ataaagctgc ttttacagaa tgttgccaag ctgctgataa agctgcctgc ctgttgccaa     4020

agctcgtgaa acttcgggtg aaagggaagg cttcgtctgc caaacagaga ctctgaaatg     4080

ccagtctcca aaaatttgga gaaagagctt tcaaagcatg ggcagtggct cgcctgagcc     4140

agagatttcc caaagctgag ctagcgaggg cctatttccc atgattcctt catatttgca     4200

tatacgatac aaggctgtta gagagataat tggaattaat ttgactgtaa acacaaagat     4260

attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg cagttttaaa     4320

attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt tcgatttctt     4380

ggctttatat atcttgtgga aaggacgaaa caccgcttaa aggcttcata taaggggttt     4440

aagtactctg tgctggaaac agcacagaat ctacttaaac aaggcaaaat gccgtgttta     4500

tctcgtcaac ttgttggcga gatttttttg gtaaccggac cgaggctgca gcgtcgtcct     4560

ccctaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4620

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4680

gagcgagcgc gcagctgcct gcagg                                           4705


<210>  65
<211>  4197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-1074

<400>  65
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgtggagc agtacggcga cgaagtttaa      420

gtactctgtg ctggaaacag cacagaatct acttaaacaa ggcaaaatgc cgtgtttatc      480

tcgtcaactt gttggcgaga tttttttcac cggtggcaca cactgtagtt catctttaca      540

tggcctcatt gaagactaca gctctggtat gcgtataagg aactagcatt aggtcatttc      600

aagccgatgc tagaatccag attccatgct gaccgatgag gatatagtga gaatctttca      660

agaacattct taaccgttgg tatcttagct ccaccctcac tggttcttcc ggccaagctg      720

ctggcctccc tcctcaaccg ttctgatcat gcttgcttag tcggccagtt aagcctgatt      780

atgacctggt tacctgttgt ctaagggcag gaatcaccgc cgtaactcta gcacttagca      840

cagtacttgg cttgtaagag gtcctcgatg atgtgaatac attaaataat taacctaaga      900

aagatttcat attaggcatt gtaatgactt aaggtaaaga gcagtgctat taacaatcca      960

gcttgtttgg gctattgtgg ctgtgggcac ctctctgggt gtatatctga ggtgctggct     1020

acctcttgga ggattataag acaatcagca acccttgcat ggtggcaaca gtaataatag     1080

ccatccttac atagtcctac agccctgtag caatggtcca acagatgagg aacctttgaa     1140

gcctcagaga ggctaacaga cagaccctag gtcatacagt tattaagaga aggcgaacct     1200

ctctcgagta ataccagtta ataggctaca caaatggtag tggctgttgt attcagttgc     1260

tgaggaatgc taaacataat tctgccaatt tccgcacccg acttcccggg ctcgggtgat     1320

tctagggctg tgtcatttgt atacgctctt gttgcccggg ctggagtaca gtggcctcag     1380

tgctcccggg ttccctacct catgcgcctg tataatagag acgaggtttc acaggctacc     1440

tgatccagtg aatatttgta ttgtagagat ggtggccatg ttcctgagct caagcgatct     1500

gcccgcctct ggccaccgtg cctggcctag gtagacgcag cgtgatgcct gagtatatag     1560

tgatgctaga gctggctgtt tgttagcttt gaacataaga tactcattgt agtttgcaaa     1620

tccctcttcc taatttcttt cccttaaatt gtttgcatgt tagcgcttaa atggtgctat     1680

gtgctagaag ccttaaatta cacaaatcag agaggtgccc aactttgaac ctaagctgct     1740

cttaatctct aaacaagtta gtagtgacaa tagtaggata cttaactatg aggcatagca     1800

ggcattatca ccctaaagtg taccctttag gtaagtatat acttgcccaa tatcacttat     1860

caaatgtgtc tgatacaacc caaactatcg aaactgccag ggtaaacttg gacacacttg     1920

agctaagaat taagtcctag aaatgtaatc ctgccctagc cgagcttacc ctgcagaatt     1980

ggtcggagca ccgtccttgg ccacactgtt atcaacaggg tgtcaatctg taggaattac     2040

tctttgtgac caccaggaaa tagagcagtt cagttcattt ctttctcact gtgacctgca     2100

tactacaagt ctactttgct atccattgtt tgtatctggg tattaccaga tcagcagaga     2160

agagttgcct tggagcagct gcagttcatt agatagtaac taggccatgt caactccctt     2220

gtagtgaaga ttgtactggt acctttctgt aaatattgtg tagatcaatc accacctcaa     2280

cccagtggct gccaaattac aataattcac tactactaag ataatctact agttcgatca     2340

catacttcct actgtcttca gcattgtgct tctgattata attgtccaga gtgaacatgt     2400

ctattcttcc actgtacaca ctaatggatt gtaatattgg gtaaattcat gtccttacac     2460

atgtagtagt tatgagccca tgtccctaga atgagtaata accttggttg aatagtcaag     2520

aatgctgaaa ttcttctaac agcagaaggg aaggcaagca agtgttactg ataagatgaa     2580

tctactatta gctttaatta tacatttagg aatattgcat cagtaactca taaggctgtt     2640

atcctgagtt aacacaaatt atccaaggag atctgctttg aggtgtgagt gtatctgatg     2700

ccaactagca attccagaag tttggaatta aattatggtt tatctattgt tatacctcaa     2760

ttatatcatg tttgctgtgc tctcggctca ctctagccac cgactccctc tgagccttgc     2820

agggtagaga caggattggc caggatggtc tccatcatga tcggcctcgt gggagccact     2880

acgcctggcc atagactcac ttccattaag tcttgtttgg acccacgaac attgtcttta     2940

agatggagtt tcacgttgcc cagactgtag tgcaatggtg caatctcagc tcactgcaac     3000

caattctcct cccgagtagc tggaattaca ggcgcccgcc accacggtgt ttcaccggcc     3060

atgatccgcc cacctcagcc tcgtgtgagc caccgcatct ggccaacatg tcttcctaga     3120

cttaagcaca gatgatgaat tgatgtgtct tagcttggat taacttgctt actgtaaaga     3180

taatatagct tgacatgaag gccattatta cagatgtgac gtgcataatt attagtatta     3240

catgggtcag tctggcaatt atgaagaata atgccagaca tttcagtaat cgattatagc     3300

gtattgacag tccagacgtc agaatttctc aatactcttt cagattaatg tacctgtagc     3360

gatatcattc acaagtatat cacaagtaag ttagaatttg agaactgtgt tctagagatg     3420

cagtcagatt tctgaactgt ctcagcaaat ggagagctag taattaataa cctgtccttt     3480

gatttctgat tcagccaaga atggccatat ttgggaagga gagtaaccac gcattcattt     3540

accacagagc tctcagctta aagccataca ggaccgtgat ctgttctagc catatgtagc     3600

atttatgtcc tagtgtgatg gtatttggag acagggcctt tggaaggtaa ttgaagtggg     3660

cccaggtctg attggattag tgcgggcgca caaggccaat cacgaggtca gccagcctgg     3720

ccaatgtagt gaaacaccaa cattagctgg gtgtggtagc gggctcctgt catccaagct     3780

acgaggcatg agaatcggga cagattgtgc cactgtgggt gactcaagag acaccagaga     3840

gcttgttaga agaggtcatg tgagcacgac cttcaagcca aagaagaggc ctgagattga     3900

aacctacctt gcaggtattc cgtgagaaat aagtttctgt taagtcactc agtctgtggt     3960

agttatggca gcctgagcag gtagttgttc tttcagaagg tgttgataat cagatgctag     4020

cggtaaccgg accgaggctg cagcgtcgtc ctccctagga acccctagtg atggagttgg     4080

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     4140

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg        4197


<210>  66
<211>  3354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-769

<400>  66
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgcgttgg agcggggaga aggccgttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggtgt ggaaagtccc caggctcccc      540

agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccacgt tacataactt      600

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg      660

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      720

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      780

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg      840

gactttccta cttggcagta catctacgct aataaaatat ctttattttc attacatctg      900

tgtgttggtt ttttgtgtga gaaaacgcca gtaagtgaca gagtcacaaa tgactgcaca      960

gagtccttgg tgaacaggcg accatgcttt tcagctctgg aagtcgtgaa aacatacgtt     1020

cccaaagagt tttgaactga aaacttcacc ttccatgcag atatatgcac actttctgag     1080

aaggagagac aaatcaagaa acaaactgca cttgttgagc ttgtgaaaca caagcccaag     1140

gcaacaaaag agcaactgaa agctgtttga gatgatttcg cagcttttgt agagaagtgc     1200

tgcaaggctg acgataagga gacctgcttt gccgaggagg gtaaaaaact tgttgctgca     1260

agtcaagctg ccttaggctt ataacatcta catttaaaag actctcagcc tacctgaaga     1320

ataagagaaa gaaatgaaag atcaaaagct tattcatctg ttttcttttt cgttggtgta     1380

aagccaacac cctgtctaaa aaacataaat ttctttaatc attttgcctc ttttctctgt     1440

gcttcaatta ataaaaaatg gaaagaatct aatagagtgg tacagcactg ttatttttca     1500

aagatgtgtt gctatcctga aaattctgta ggttctgtgg aagttccagt gttctctctt     1560

attccacttc ggtagaggat ttctagtttc tgtgggctaa ttaaataaat cactaatact     1620

cttctaagtt aagtttgcag aagtttccaa gttagtgaca gatcttacca aagtccacac     1680

ggaatgctgc ctgagagatc tgcttgaatg tgctgatgac agggcggacc ttgccaagta     1740

tatctgtgaa aatcaggatt cgatctccag taaactgaag gaatgctgtg aaaaacctct     1800

gttggaaaaa tcccactgca ttgccgaagt ggaaaatgat gagtgacctg ctgacttgcc     1860

ttacttagct gctgattttg ttgaaagtaa ggtgatttgc aaaaacttga ctgaggcaaa     1920

ggatgtcttc ctgggctgat ttttgtatga atatgcaaga aggactcctg attactctgt     1980

cgtgctgctg ctgagacttg ccaagaacta tgaaaccaca gatctgaagt gctgtgccgc     2040

tgcagatcct actgaatgct atgccaaagt gttcgatgaa tttaaacctc ttgtggaaga     2100

gcctcagaat ttaatcaaac aaaactgtga gctttttgag cagcttggag agtacaaatt     2160

ccagaatgcg ctattagttc gttacaccaa gaaagtaccc caagtgtcaa ctccaactct     2220

tgtagaggtc tcaagaaacc tcggaaaagt gggcagcaaa tgttgtaaac atcctgaagc     2280

aaaaagatga ccctgtgcag aagactatct atccgtggtc ctgaaccagt tatgtgtgtt     2340

gcatgaggat gtcttctggc aatttcatat aagtattttt tcaaaatgat ctcttctgtc     2400

aaccccacgc ctttggcaca tgaaagtggg taacctttat ttcccttctt tttctcttta     2460

gctcggctta ttccaggggt gtgtttcgtc gagatgcaca caagagtgag gttgctactc     2520

ggtttaaaga tttgggagaa gaaaatttca aagccttggt gttgattgcc tttgctcagt     2580

atcttcagca gtgtccattt gaagatactg taaaattagt gaatgaagta actgaatttg     2640

caaaaaactg tgtagctgtg aagtcagctg aaaattgtga caaatcactt catacccttt     2700

ttggagacaa attatgcaca gttgcaactc ttcgtgaaac cttgagtgaa tgagctgact     2760

gctgtgcaaa acaagaacct gagagatgaa aatgcttctt gcaacacaaa gtgaacaacc     2820

caaacctccc ccgattggtc agaccagagg ttgatgtgtg atgcactgct tttactgaca     2880

atgaagagac atttttgaaa aaatacttat tgaaaattgc cagaagaact ccttactttt     2940

tgaccccgga actccttttc tttgctaaaa ggtataaagc tgcttttaca gaatgttgcc     3000

aagctgctga taaagctgcc tgcctgttgc caaagctcgt gaaacttcgg gtgaaaggga     3060

aggcttcgtc tgccaaacag agactctgaa atgccagtct ccaaaaattt ggagaaagag     3120

ctttcaaagc atgggcagtg gctcgcctga gccagagatt tcccaaagct gagctagcgg     3180

tacccggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     3240

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3300

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg           3354


<210>  67
<211>  4311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-1047

<400>  67
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgaattc cgttacataa cttacggtaa atggcccgcc      180

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      240

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      300

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      360

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      420

gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa      480

tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa      540

tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc      600

cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctcg      660

tttagtgaac cgtgctagca ctcattgtat gtagaagacc tctaaggcca ccatggcccc      720

aaagaagaag cggaaggtcg gatccggaaa gcggaactat atcctgggac tggacatcgg      780

aattacctcc gtgggatacg gcatcatcga ttacgagact agggacgtga ttgacgccgg      840

cgtgagactc tttaaggagg ccaacgtgga aaacaacgaa ggtcgcagat ccaagcgggg      900

tgcaagacgc ctgaagcgcc ggaggagaca tcggatacag cgcgtgaaga agctcctttt      960

cgactacaac ctcctcactg accactcgga attgtccggt atcaacccct acgaagcccg     1020

cgtgaaaggc ctgagccaga agctgtccga agaggagttt agcgcagccc tgctgcacct     1080

ggctaagcga aggggggtgc acaacgtgaa cgaggtggag gaggacactg gcaacgaact     1140

gtccaccaag gagcagattt cacggaactc gaaggcgctg gaagagaaat atgtggccga     1200

gctgcagctg gagaggctca agaaggatgg cgaagtccgg gggagcatca atcgcttcaa     1260

gacctcggac tacgtgaagg aagccaaaca gctgttgaag gtgcagaagg cctaccacca     1320

actggaccaa tcattcattg acacttacat cgatctgctt gaaaccaggc gcacctacta     1380

cgagggtcct ggagaaggca gccctttcgg atggaaggac atcaaggagt ggtatgagat     1440

gctgatgggt cattgcacct actttccgga agaactgcgc tcagtgaagt acgcgtacaa     1500

cgctgacctc tacaacgctc tcaacgatct gaacaacctc gtgatcaccc gggacgagaa     1560

cgaaaagctg gagtactacg aaaagttcca gattatcgaa aacgtgttca agcagaagaa     1620

gaagcccacc ctgaagcaga ttgcaaagga gatccttgtg aacgaggagg atattaaggg     1680

ctaccgggtc acctccaccg ggaaaccaga gttcactaat ctcaaggtgt accatgacat     1740

taaggacatt actgcccgca aggagatcat tgaaaacgcg gaactgctgg accaaatcgc     1800

gaagatcctg accatctatc agagctccga ggatatccag gaggaactta ctaacctcaa     1860

ttccgagctg acgcaggaag aaatcgagca aattagcaac ctgaagggtt acactggaac     1920

ccacaacctc agcttgaaag cgattaacct tattttggat gaactttggc acactaatga     1980

caatcagatc gccattttca accggctgaa actggtgccg aagaaggtgg acctgagcca     2040

acagaaggaa atcccgacca cccttgtgga cgatttcatc ctgtcacctg tggtgaagag     2100

gagcttcatc cagtcgatca aggtcatcaa cgccatcata aagaagtacg gccttcccaa     2160

cgacatcatc atcgaactgg cccgcgagaa gaactccaaa gatgcccaga agatgatcaa     2220

cgagatgcag aagcgaaacc ggcagacgaa cgaacggatc gaggagatca tccggaccac     2280

cgggaaggaa aacgcgaagt acctgatcga gaaaatcaag ctgcatgata tgcaggaagg     2340

gaagtgtctc tactccctgg aggccattcc gctggaggat ttgctgaaca accctttcaa     2400

ctacgaagtc gatcatatca ttcctcgctc cgtgtccttc gataactcct tcaacaataa     2460

ggtcctcgtg aagcaggagg agaagtaagt atcaaggtta caagacagct attctgagta     2520

cagagcatac agagtcttgt cgagacagag aagactcttg cgtttctgat aggcacctat     2580

tggtcttact gacatccact ttgcctttct ctccacagct cgaagaaggg caacagaacc     2640

ccgttccagt acctctcgtc gtccgactcc aagatcagct acgaaacttt caagaagcac     2700

attctgaacc tggccaaggg caaagggaga attagcaaga ccaagaagga atacctcctg     2760

gaagagagag acatcaaccg cttctcggtg caaaaggatt tcatcaaccg caacctggtc     2820

gataccagat acgccaccag gggactgatg aacctcctgc ggtcctactt ccgggtcaac     2880

aatctggacg tgaaggtcaa atccatcaac gggggcttta cttctttcct gcgccggaag     2940

tggaagttca agaaggaacg gaacaaggga tacaagcacc acgctgaaga tgccctgatt     3000

attgccaacg ccgacttcat ctttaaggaa tggaaaaagc tggacaaggc taagaaggtc     3060

atggagaacc agatgttcga agaaaagcag gccgagtcca tgcccgaaat cgaaaccgag     3120

caggaataca aggagatctt catcacaccg caccaaatca agcacatcaa ggacttcaag     3180

gattacaagt acagccaccg ggtggacaag aagcctaaca gagagcttat caacgacacc     3240

ctgtactcca cgcgcaagga cgacaaggga aacacattga tcgtgaacaa cctgaacgga     3300

ctgtatgaca aggacaatga caaactgaag aagctgatca acaaatcgcc ggaaaagctc     3360

ctgatgtacc atcacgaccc tcaaacctac cagaaactga agctcatcat ggagcagtac     3420

ggcgacgaaa agaatcccct gtacaaatac tacgaggaga ctggaaatta cctgactaag     3480

tactccaaga aggataacgg ccccgtgatc aagaagatta agtactacgg aaacaaactg     3540

aacgcacatc tcgacatcac cgatgattat ccaaactccc gcaacaaagt cgtgaagctc     3600

tccctcaaac cgtaccgctt cgacgtgtac ctggataatg gggtgtacaa gttcgtgacc     3660

gtgaagaacc tggacgtcat taagaaggaa aactactacg aagtgaactc aaagtgctac     3720

gaggaagcca agaagctcaa gaagatcagc aaccaggccg agttcatcgc atcgttttac     3780

aacaatgacc tcattaagat taatggagaa ctgtacagag tgatcggcgt gaacaacgac     3840

ctcctgaacc ggattgaagt gaacatgatc gatattacct accgggagta tctggagaac     3900

atgaacgaca agcgcccacc gagaatcatc aaaactattg cctccaagac ccaatccatt     3960

aagaaatact ccaccgacat cctgggcaac ctgtacgagg tcaagtcgaa gaagcacccc     4020

cagattatca agaagggaaa gcttgcccca aagaagaagc ggaaggtcta aggtactagt     4080

aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtga gcgctggtaa     4140

ccggaccgag gctgcagcgt cgtcctccct aggaacccct agtgatggag ttggccactc     4200

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4260

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4311


<210>  68
<211>  4562
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-1070

<400>  68
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgcttaga ggtcttctac atacagttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggcac acactgtagt tcatctttac      540

atggcctcat tgaagactac agctctggta tgcgtataag gaactagcat taggtcattt      600

caagccgatg ctagaatcca gattccatgc tgaccgatga ggatatagtg agaatctttc      660

aagaacattc ttaaccgttg gtatcttagc tccaccctca ctggttcttc cggccaagct      720

gctggcctcc ctcctcaacc gttctgatca tgcttgctta gtcggccagt taagcctgat      780

tatgacctgg ttacctgttg tctaagggca ggaatcaccg ccgtaactct agcacttagc      840

acagtacttg gcttgtaaga ggtcctcgat gatgtgaata cattaaataa ttaacctaag      900

aaagatttca tattaggcat tgtaatgact taaggtaaag agcagtgcta ttaacaatcc      960

agcttgtttg ggctattgtg gctgtgggca cctctctggg tgtatatctg aggtgctggc     1020

tacctcttgg aggattataa gacaatcagc aacccttgca tggtggcaac agtaataata     1080

gccatcctta catagtccta cagccctgta gcaatggtcc aacagatgag gaacctttga     1140

agcctcagag aggctaacag acagacccta ggtcatacag ttattaagag aaggcgaacc     1200

tctctcgagt aataccagtt aataggctac acaaatggta gtggctgttg tattcagttg     1260

ctgaggaatg ctaaacataa ttctgccaat ttccgcaccc gacttcccgg gctcgggtga     1320

ttctagggct gtgtcatttg tatacgctct tgttgcccgg gctggagtac agtggcctca     1380

gtgctcccgg gttccctacc tcatgcgcct gtataataga gacgaggttt cacaggctac     1440

ctgatccagt gaatatttgt attgtagaga tggtggccat gttcctgagc tcaagcgatc     1500

tgcccgcctc tggccaccgt gcctggccta ggtagacgca gcgtgatgcc tgagtatata     1560

gtgatgctag agctggctgt ttgttagctt tgaacataag atactcattg tagtttgcaa     1620

atccctcttc ctaatttctt tcccttaaat tgtttgcatg ttagcgctta aatggtgcta     1680

tgtgctagaa gccttaaatt acacaaatca gagaggtgcc caactttgaa cctaagctgc     1740

tcttaatctc taaacaagtt agtagtgaca atagtaggat acttaactat gaggcatagc     1800

aggcattatc accctaaagt gtacccttta ggtaagtata tacttgccca atatcactta     1860

tcaaatgtgt ctgatacaac ccaaactatc gaaactgcca gggtaaactt ggacacactt     1920

gagctaagaa ttaagtccta gaaatgtaat cctgccctag ccgagcttac cctgcagaat     1980

tggtcggagc accgtccttg gccacactgt tatcaacagg gtgtcaatct gtaggaatta     2040

ctctttgtga ccaccaggaa atagagcagt tcagttcatt tctttctcac tgtgacctgc     2100

atactacaag tctactttgc tatccattgt ttgtatctgg gtattaccag atcagcagag     2160

aagagttgcc ttggagcagc tgcagttcat tagatagtaa ctaggccatg tcaactccct     2220

tgtagtgaag attgtactgg tacctttctg taaatattgt gtagatcaat caccacctca     2280

acccagtggc tgccaaatta caataattca ctactactaa gataatctac tagttcgatc     2340

acatacttcc tactgtcttc agcattgtgc ttctgattat aattgtccag agtgaacatg     2400

tctattcttc cactgtacac actaatggat tgtaatattg ggtaaattca tgtccttaca     2460

catgtagtag ttatgagccc atgtccctag aatgagtaat aaccttggtt gaatagtcaa     2520

gaatgctgaa attcttctaa cagcagaagg gaaggcaagc aagtgttact gataagatga     2580

atctactatt agctttaatt atacatttag gaatattgca tcagtaactc ataaggctgt     2640

tatcctgagt taacacaaat tatccaagga gatctgcttt gaggtgtgag tgtatctgat     2700

gccaactagc aattccagaa gtttggaatt aaattatggt ttatctattg ttatacctca     2760

attatatcat gtttgctgtg ctctcggctc actctagcca ccgactccct ctgagccttg     2820

cagggtagag acaggattgg ccaggatggt ctccatcatg atcggcctcg tgggagccac     2880

tacgcctggc catagactca cttccattaa gtcttgtttg gacccacgaa cattgtcttt     2940

aagatggagt ttcacgttgc ccagactgta gtgcaatggt gcaatctcag ctcactgcaa     3000

ccaattctcc tcccgagtag ctggaattac aggcgcccgc caccacggtg tttcaccggc     3060

catgatccgc ccacctcagc ctcgtgtgag ccaccgcatc tggccaacat gtcttcctag     3120

acttaagcac agatgatgaa ttgatgtgtc ttagcttgga ttaacttgct tactgtaaag     3180

ataatatagc ttgacatgaa ggccattatt acagatgtga cgtgcataat tattagtatt     3240

acatgggtca gtctggcaat tatgaagaat aatgccagac atttcagtaa tcgattatag     3300

cgtattgaca gtccagacgt cagaatttct caatactctt tcagattaat gtacctgtag     3360

cgatatcatt cacaagtata tcacaagtaa gttagaattt gagaactgtg ttctagagat     3420

gcagtcagat ttctgaactg tctcagcaaa tggagagcta gtaattaata acctgtcctt     3480

tgatttctga ttcagccaag aatggccata tttgggaagg agagtaacca cgcattcatt     3540

taccacagag ctctcagctt aaagccatac aggaccgtga tctgttctag ccatatgtag     3600

catttatgtc ctagtgtgat ggtatttgga gacagggcct ttggaaggta attgaagtgg     3660

gcccaggtct gattggatta gtgcgggcgc acaaggccaa tcacgaggtc agccagcctg     3720

gccaatgtag tgaaacacca acattagctg ggtgtggtag cgggctcctg tcatccaagc     3780

tacgaggcat gagaatcggg acagattgtg ccactgtggg tgactcaaga gacaccagag     3840

agcttgttag aagaggtcat gtgagcacga ccttcaagcc aaagaagagg cctgagattg     3900

aaacctacct tgcaggtatt ccgtgagaaa taagtttctg ttaagtcact cagtctgtgg     3960

tagttatggc agcctgagca ggtagttgtt ctttcagaag gtgttgataa tcagatgcta     4020

gcgagggcct atttcccatg attccttcat atttgcatat acgatacaag gctgttagag     4080

agataattgg aattaatttg actgtaaaca caaagatatt agtacaaaat acgtgacgta     4140

gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa atggactatc     4200

atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag     4260

gacgaaacac cgctattctg agtacagagc atagtttaag tactctgtgc tggaaacagc     4320

acagaatcta cttaaacaag gcaaaatgcc gtgtttatct cgtcaacttg ttggcgagat     4380

ttttttggta accggaccga ggctgcagcg tcgtcctccc taggaacccc tagtgatgga     4440

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4500

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     4560

gg                                                                    4562


<210>  69
<211>  4833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-525

<400>  69
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtgtg gaaagtcccc aggctcccca gcaggcagaa      180

gtatgcaaag catgcatctc aattagtcag caaccacgtt acataactta cggtaaatgg      240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      600

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      660

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      720

agctcgttta gtgaaccgtc accgactatg attaaatgct tgatattgag tgccaccatg      780

gccccaaaga agaagcggaa ggtcggatcc ggaaagcgga actatatcct gggactggac      840

atcggaatta cctccgtggg atacggcatc atcgattacg agactaggga cgtgattgac      900

gccggcgtga gactctttaa ggaggccaac gtggaaaaca acgaaggtcg cagatccaag      960

cggggtgcaa gacgcctgaa gcgccggagg agacatcgga tacagcgcgt gaagaagctc     1020

cttttcgact acaacctcct cactgaccac tcggaattgt ccggtatcaa cccctacgaa     1080

gcccgcgtga aaggcctgag ccagaagctg tccgaagagg agtttagcgc agccctgctg     1140

cacctggcta agcgaagggg ggtgcacaac gtgaacgagg tggaggagga cactggcaac     1200

gaactgtcca ccaaggagca gatttcacgg aactcgaagg cgctggaaga gaaatatgtg     1260

gccgagctgc agctggagag gctcaagaag gatggcgaag tccgggggag catcaatcgc     1320

ttcaagacct cggactacgt gaaggaagcc aaacagctgt tgaaggtgca gaaggcctac     1380

caccaactgg accaatcatt cattgacact tacatcgatc tgcttgaaac caggcgcacc     1440

tactacgagg gtcctggaga aggcagccct ttcggatgga aggacatcaa ggagtggtat     1500

gagatgctga tgggtcattg cacctacttt ccggaagaac tgcgctcagt gaagtacgcg     1560

tacaacgctg acctctacaa cgctctcaac gatctgaaca acctcgtgat cacccgggac     1620

gagaacgaaa agctggagta ctacgaaaag ttccagatta tcgaaaacgt gttcaagcag     1680

aagaagaagc ccaccctgaa gcagattgca aaggagatcc ttgtgaacga ggaggatatt     1740

aagggctacc gggtcacctc caccgggaaa ccagagttca ctaatctcaa ggtgtaccat     1800

gacattaagg acattactgc ccgcaaggag atcattgaaa acgcggaact gctggaccaa     1860

atcgcgaaga tcctgaccat ctatcagagc tccgaggata tccaggagga acttactaac     1920

ctcaattccg agctgacgca ggaagaaatc gagcaaatta gcaacctgaa gggttacact     1980

ggaacccaca acctcagctt gaaagcgatt aaccttattt tggatgaact ttggcacact     2040

aatgacaatc agatcgccat tttcaaccgg ctgaaactgg tgccgaagaa ggtggacctg     2100

agccaacaga aggaaatccc gaccaccctt gtggacgatt tcatcctgtc acctgtggtg     2160

aagaggagct tcatccagtc gatcaaggtc atcaacgcca tcataaagaa gtacggcctt     2220

cccaacgaca tcatcatcga actggcccgc gagaagaact ccaaagatgc ccagaagatg     2280

atcaacgaga tgcagaagcg aaaccggcag acgaacgaac ggatcgagga gatcatccgg     2340

accaccggga aggaaaacgc gaagtacctg atcgagaaaa tcaagctgca tgatatgcag     2400

gaagggaagt gtctctactc cctggaggcc attccgctgg aggatttgct gaacaaccct     2460

ttcaactacg aagtcgatca tatcattcct cgctccgtgt ccttcgataa ctccttcaac     2520

aataaggtcc tcgtgaagca ggaggagaag taagtatcaa ggttacaaga cagcttaaag     2580

gcttcatata agggtggaat cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2640

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2700

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2760

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2820

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2880

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2940

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     3000

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     3060

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     3120

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     3180

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     3240

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3300

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3360

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3420

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3480

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3540

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3600

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3660

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3720

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3780

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3840

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3900

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3960

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     4020

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     4080

acccccagat tatcaagaag ggaaagcttg ccccaaagaa gaagcggaag gtcggtacta     4140

gtgagggcag gggaagtctg ctaacatgcg gggacgtgga ggaaaatccc ggccccatgg     4200

ctaagacttc cgaacagagg gtgaacattg ctacactgct gacagaaaat aagaagaaaa     4260

tcgtggataa ggcttcccag gatctgtggc ggagacaccc agacctgatc gcaccaggag     4320

gaattgcttt ctctcagagg gaccgcgctc tgtgcctgcg agattacggc tggttcctgc     4380

atctgatcac cttttgtctg ctggccggag ataagggccc catcgagtct attgggctga     4440

tcagtattcg agaaatgtat aactcactgg gagtgcccgt ccctgcaatg atggagagca     4500

ttagatgcct gaaagaagcc agcctgtccc tgctggacga agaggacgcc aacgagaccg     4560

caccctactt tgattacatt attaaggcta tgagctaagc gctaataaaa tatctttatt     4620

ttcattacat ctgtgtgttg gttttttgtg tggtaaccac gtgcggaccg aggctgcagc     4680

gtcgtcctcc ctaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4740

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4800

cagtgagcga gcgagcgcgc agctgcctgc agg                                  4833


<210>  70
<211>  4311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-1048

<400>  70
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgaattc cgttacataa cttacggtaa atggcccgcc      180

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      240

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      300

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      360

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      420

gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa      480

tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa      540

tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc      600

cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctcg      660

tttagtgaac cgtgctagca tccacatagt gtacttacag tcagaagcca ccatggcccc      720

aaagaagaag cggaaggtcg gatccggaaa gcggaactat atcctgggac tggacatcgg      780

aattacctcc gtgggatacg gcatcatcga ttacgagact agggacgtga ttgacgccgg      840

cgtgagactc tttaaggagg ccaacgtgga aaacaacgaa ggtcgcagat ccaagcgggg      900

tgcaagacgc ctgaagcgcc ggaggagaca tcggatacag cgcgtgaaga agctcctttt      960

cgactacaac ctcctcactg accactcgga attgtccggt atcaacccct acgaagcccg     1020

cgtgaaaggc ctgagccaga agctgtccga agaggagttt agcgcagccc tgctgcacct     1080

ggctaagcga aggggggtgc acaacgtgaa cgaggtggag gaggacactg gcaacgaact     1140

gtccaccaag gagcagattt cacggaactc gaaggcgctg gaagagaaat atgtggccga     1200

gctgcagctg gagaggctca agaaggatgg cgaagtccgg gggagcatca atcgcttcaa     1260

gacctcggac tacgtgaagg aagccaaaca gctgttgaag gtgcagaagg cctaccacca     1320

actggaccaa tcattcattg acacttacat cgatctgctt gaaaccaggc gcacctacta     1380

cgagggtcct ggagaaggca gccctttcgg atggaaggac atcaaggagt ggtatgagat     1440

gctgatgggt cattgcacct actttccgga agaactgcgc tcagtgaagt acgcgtacaa     1500

cgctgacctc tacaacgctc tcaacgatct gaacaacctc gtgatcaccc gggacgagaa     1560

cgaaaagctg gagtactacg aaaagttcca gattatcgaa aacgtgttca agcagaagaa     1620

gaagcccacc ctgaagcaga ttgcaaagga gatccttgtg aacgaggagg atattaaggg     1680

ctaccgggtc acctccaccg ggaaaccaga gttcactaat ctcaaggtgt accatgacat     1740

taaggacatt actgcccgca aggagatcat tgaaaacgcg gaactgctgg accaaatcgc     1800

gaagatcctg accatctatc agagctccga ggatatccag gaggaactta ctaacctcaa     1860

ttccgagctg acgcaggaag aaatcgagca aattagcaac ctgaagggtt acactggaac     1920

ccacaacctc agcttgaaag cgattaacct tattttggat gaactttggc acactaatga     1980

caatcagatc gccattttca accggctgaa actggtgccg aagaaggtgg acctgagcca     2040

acagaaggaa atcccgacca cccttgtgga cgatttcatc ctgtcacctg tggtgaagag     2100

gagcttcatc cagtcgatca aggtcatcaa cgccatcata aagaagtacg gccttcccaa     2160

cgacatcatc atcgaactgg cccgcgagaa gaactccaaa gatgcccaga agatgatcaa     2220

cgagatgcag aagcgaaacc ggcagacgaa cgaacggatc gaggagatca tccggaccac     2280

cgggaaggaa aacgcgaagt acctgatcga gaaaatcaag ctgcatgata tgcaggaagg     2340

gaagtgtctc tactccctgg aggccattcc gctggaggat ttgctgaaca accctttcaa     2400

ctacgaagtc gatcatatca ttcctcgctc cgtgtccttc gataactcct tcaacaataa     2460

ggtcctcgtg aagcaggagg agaagtaagt atcaaggtta caagacagct attctgagta     2520

cagagcatac agagtcttgt cgagacagag aagactcttg cgtttctgat aggcacctat     2580

tggtcttact gacatccact ttgcctttct ctccacagct cgaagaaggg caacagaacc     2640

ccgttccagt acctctcgtc gtccgactcc aagatcagct acgaaacttt caagaagcac     2700

attctgaacc tggccaaggg caaagggaga attagcaaga ccaagaagga atacctcctg     2760

gaagagagag acatcaaccg cttctcggtg caaaaggatt tcatcaaccg caacctggtc     2820

gataccagat acgccaccag gggactgatg aacctcctgc ggtcctactt ccgggtcaac     2880

aatctggacg tgaaggtcaa atccatcaac gggggcttta cttctttcct gcgccggaag     2940

tggaagttca agaaggaacg gaacaaggga tacaagcacc acgctgaaga tgccctgatt     3000

attgccaacg ccgacttcat ctttaaggaa tggaaaaagc tggacaaggc taagaaggtc     3060

atggagaacc agatgttcga agaaaagcag gccgagtcca tgcccgaaat cgaaaccgag     3120

caggaataca aggagatctt catcacaccg caccaaatca agcacatcaa ggacttcaag     3180

gattacaagt acagccaccg ggtggacaag aagcctaaca gagagcttat caacgacacc     3240

ctgtactcca cgcgcaagga cgacaaggga aacacattga tcgtgaacaa cctgaacgga     3300

ctgtatgaca aggacaatga caaactgaag aagctgatca acaaatcgcc ggaaaagctc     3360

ctgatgtacc atcacgaccc tcaaacctac cagaaactga agctcatcat ggagcagtac     3420

ggcgacgaaa agaatcccct gtacaaatac tacgaggaga ctggaaatta cctgactaag     3480

tactccaaga aggataacgg ccccgtgatc aagaagatta agtactacgg aaacaaactg     3540

aacgcacatc tcgacatcac cgatgattat ccaaactccc gcaacaaagt cgtgaagctc     3600

tccctcaaac cgtaccgctt cgacgtgtac ctggataatg gggtgtacaa gttcgtgacc     3660

gtgaagaacc tggacgtcat taagaaggaa aactactacg aagtgaactc aaagtgctac     3720

gaggaagcca agaagctcaa gaagatcagc aaccaggccg agttcatcgc atcgttttac     3780

aacaatgacc tcattaagat taatggagaa ctgtacagag tgatcggcgt gaacaacgac     3840

ctcctgaacc ggattgaagt gaacatgatc gatattacct accgggagta tctggagaac     3900

atgaacgaca agcgcccacc gagaatcatc aaaactattg cctccaagac ccaatccatt     3960

aagaaatact ccaccgacat cctgggcaac ctgtacgagg tcaagtcgaa gaagcacccc     4020

cagattatca agaagggaaa gcttgcccca aagaagaagc ggaaggtcta aggtactagt     4080

aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtga gcgctggtaa     4140

ccggaccgag gctgcagcgt cgtcctccct aggaacccct agtgatggag ttggccactc     4200

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4260

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4311


<210>  71
<211>  4562
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTX-1075

<400>  71
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat      180

atacgataca aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata      240

ttagtacaaa atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa      300

ttatgtttta aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg      360

gctttatata tcttgtggaa aggacgaaac accgttctga ctgtaagtac actatgttta      420

agtactctgt gctggaaaca gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat      480

ctcgtcaact tgttggcgag atttttttca ccggtggcac acactgtagt tcatctttac      540

atggcctcat tgaagactac agctctggta tgcgtataag gaactagcat taggtcattt      600

caagccgatg ctagaatcca gattccatgc tgaccgatga ggatatagtg agaatctttc      660

aagaacattc ttaaccgttg gtatcttagc tccaccctca ctggttcttc cggccaagct      720

gctggcctcc ctcctcaacc gttctgatca tgcttgctta gtcggccagt taagcctgat      780

tatgacctgg ttacctgttg tctaagggca ggaatcaccg ccgtaactct agcacttagc      840

acagtacttg gcttgtaaga ggtcctcgat gatgtgaata cattaaataa ttaacctaag      900

aaagatttca tattaggcat tgtaatgact taaggtaaag agcagtgcta ttaacaatcc      960

agcttgtttg ggctattgtg gctgtgggca cctctctggg tgtatatctg aggtgctggc     1020

tacctcttgg aggattataa gacaatcagc aacccttgca tggtggcaac agtaataata     1080

gccatcctta catagtccta cagccctgta gcaatggtcc aacagatgag gaacctttga     1140

agcctcagag aggctaacag acagacccta ggtcatacag ttattaagag aaggcgaacc     1200

tctctcgagt aataccagtt aataggctac acaaatggta gtggctgttg tattcagttg     1260

ctgaggaatg ctaaacataa ttctgccaat ttccgcaccc gacttcccgg gctcgggtga     1320

ttctagggct gtgtcatttg tatacgctct tgttgcccgg gctggagtac agtggcctca     1380

gtgctcccgg gttccctacc tcatgcgcct gtataataga gacgaggttt cacaggctac     1440

ctgatccagt gaatatttgt attgtagaga tggtggccat gttcctgagc tcaagcgatc     1500

tgcccgcctc tggccaccgt gcctggccta ggtagacgca gcgtgatgcc tgagtatata     1560

gtgatgctag agctggctgt ttgttagctt tgaacataag atactcattg tagtttgcaa     1620

atccctcttc ctaatttctt tcccttaaat tgtttgcatg ttagcgctta aatggtgcta     1680

tgtgctagaa gccttaaatt acacaaatca gagaggtgcc caactttgaa cctaagctgc     1740

tcttaatctc taaacaagtt agtagtgaca atagtaggat acttaactat gaggcatagc     1800

aggcattatc accctaaagt gtacccttta ggtaagtata tacttgccca atatcactta     1860

tcaaatgtgt ctgatacaac ccaaactatc gaaactgcca gggtaaactt ggacacactt     1920

gagctaagaa ttaagtccta gaaatgtaat cctgccctag ccgagcttac cctgcagaat     1980

tggtcggagc accgtccttg gccacactgt tatcaacagg gtgtcaatct gtaggaatta     2040

ctctttgtga ccaccaggaa atagagcagt tcagttcatt tctttctcac tgtgacctgc     2100

atactacaag tctactttgc tatccattgt ttgtatctgg gtattaccag atcagcagag     2160

aagagttgcc ttggagcagc tgcagttcat tagatagtaa ctaggccatg tcaactccct     2220

tgtagtgaag attgtactgg tacctttctg taaatattgt gtagatcaat caccacctca     2280

acccagtggc tgccaaatta caataattca ctactactaa gataatctac tagttcgatc     2340

acatacttcc tactgtcttc agcattgtgc ttctgattat aattgtccag agtgaacatg     2400

tctattcttc cactgtacac actaatggat tgtaatattg ggtaaattca tgtccttaca     2460

catgtagtag ttatgagccc atgtccctag aatgagtaat aaccttggtt gaatagtcaa     2520

gaatgctgaa attcttctaa cagcagaagg gaaggcaagc aagtgttact gataagatga     2580

atctactatt agctttaatt atacatttag gaatattgca tcagtaactc ataaggctgt     2640

tatcctgagt taacacaaat tatccaagga gatctgcttt gaggtgtgag tgtatctgat     2700

gccaactagc aattccagaa gtttggaatt aaattatggt ttatctattg ttatacctca     2760

attatatcat gtttgctgtg ctctcggctc actctagcca ccgactccct ctgagccttg     2820

cagggtagag acaggattgg ccaggatggt ctccatcatg atcggcctcg tgggagccac     2880

tacgcctggc catagactca cttccattaa gtcttgtttg gacccacgaa cattgtcttt     2940

aagatggagt ttcacgttgc ccagactgta gtgcaatggt gcaatctcag ctcactgcaa     3000

ccaattctcc tcccgagtag ctggaattac aggcgcccgc caccacggtg tttcaccggc     3060

catgatccgc ccacctcagc ctcgtgtgag ccaccgcatc tggccaacat gtcttcctag     3120

acttaagcac agatgatgaa ttgatgtgtc ttagcttgga ttaacttgct tactgtaaag     3180

ataatatagc ttgacatgaa ggccattatt acagatgtga cgtgcataat tattagtatt     3240

acatgggtca gtctggcaat tatgaagaat aatgccagac atttcagtaa tcgattatag     3300

cgtattgaca gtccagacgt cagaatttct caatactctt tcagattaat gtacctgtag     3360

cgatatcatt cacaagtata tcacaagtaa gttagaattt gagaactgtg ttctagagat     3420

gcagtcagat ttctgaactg tctcagcaaa tggagagcta gtaattaata acctgtcctt     3480

tgatttctga ttcagccaag aatggccata tttgggaagg agagtaacca cgcattcatt     3540

taccacagag ctctcagctt aaagccatac aggaccgtga tctgttctag ccatatgtag     3600

catttatgtc ctagtgtgat ggtatttgga gacagggcct ttggaaggta attgaagtgg     3660

gcccaggtct gattggatta gtgcgggcgc acaaggccaa tcacgaggtc agccagcctg     3720

gccaatgtag tgaaacacca acattagctg ggtgtggtag cgggctcctg tcatccaagc     3780

tacgaggcat gagaatcggg acagattgtg ccactgtggg tgactcaaga gacaccagag     3840

agcttgttag aagaggtcat gtgagcacga ccttcaagcc aaagaagagg cctgagattg     3900

aaacctacct tgcaggtatt ccgtgagaaa taagtttctg ttaagtcact cagtctgtgg     3960

tagttatggc agcctgagca ggtagttgtt ctttcagaag gtgttgataa tcagatgcta     4020

gcgagggcct atttcccatg attccttcat atttgcatat acgatacaag gctgttagag     4080

agataattgg aattaatttg actgtaaaca caaagatatt agtacaaaat acgtgacgta     4140

gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa atggactatc     4200

atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag     4260

gacgaaacac cgctattctg agtacagagc atagtttaag tactctgtgc tggaaacagc     4320

acagaatcta cttaaacaag gcaaaatgcc gtgtttatct cgtcaacttg ttggcgagat     4380

ttttttggta accggaccga ggctgcagcg tcgtcctccc taggaacccc tagtgatgga     4440

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4500

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     4560

gg                                                                    4562


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SV40 NLS

<400>  72

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SV40 NLS

<400>  73

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS of nucleoplasmin

<400>  74

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L22BS

<400>  75
gtgtattgct tgtactactc actgaat                                           27


