                               SEQUENCE LISTING

<110> MODERNATX, INC.
 
<120> COMPOSITIONS FOR SKIN AND WOUNDS AND METHODS OF USE THEREOF

<130> 45817-0054WO1

<140>
<141>

<150> 62/845,134
<151> 2019-05-08

<160> 273   

<170> PatentIn version 3.5

<210> 1
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucug       60

cugucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccaugc caaguggucc      120

caggcugcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gaugucuauc agcgcagcua cugccaucca aucgagaccc ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggg      300

ggcugcugca augacgaggg ccuggagugu gugcccacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 2
<211> 846
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
ggaggaaaua agagagaaaa gaagaguaag aagaaauaua agagccacca ugaacuuucu       60

gcugucuugg gugcauugga gccuugccuu gcugcucuac cuccaccaug ccaagugguc      120

ccaggcugca cccauggcag aaggaggagg gcagaaucau cacgaagugg ugaaguucau      180

ggaugucuau cagcgcagcu acugccaucc aaucgagacc cugguggaca ucuuccagga      240

guacccugau gagaucgagu acaucuucaa gccauccugu gugccccuga ugcgaugcgg      300

gggcugcugc aaugacgagg gccuggagug ugugcccacu gaggagucca acaucaccau      360

gcagauuaug cggaucaaac cucaccaagg ccagcacaua ggagagauga gcuuccuaca      420

gcacaacaaa ugugaaugca gaccaaagaa agauagagca agacaagaaa aucccugugg      480

gccuugcuca gagcggagaa agcauuuguu uguacaagau ccgcagacgu guaaauguuc      540

cugcaaaaac acagacucgc guugcaaggc gaggcagcuu gaguuaaacg aacguacuug      600

cagaugugac aagccgaggc ggugauaaua ggcuggagcc ucgguggcca ugcuucuugc      660

cccuugggcc uccccccagc cccuccuccc cuuccugcac ccguaccccc guggucuuug      720

aauaaagucu gagugggcgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aucuag                                                                 846


<210> 3
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 4
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 5
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucuc       60

cuuucuuggg ugcauuggag ccuugccuug uuacucuacc uccaccacgc caaguggucc      120

caggccgcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gacgucuauc agcgcagcua cugccaucca aucgagacac ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggc      300

ggcugcugca augacgaggg ccuggagugu gugccuacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagagaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaagaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 6
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
gaggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucug       60

cugucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccaugc caaguggucc      120

caggcugcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gaugucuauc agcgcagcua cugccaucca aucgagaccc ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggg      300

ggcugcugca augacgaggg ccuggagugu gugcccacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 7
<211> 840
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccac gaacuuugug       60

cucucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccacgc caaguggucc      120

caggccgcac ccacggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucacg      180

gacgucuauc agcgcagcua cugccaucca aucgagaccc ucguggacau cuuccaggag      240

uacccucacg agaucgagua caucuucaag ccauccugug ugccccugac gcgacgcggg      300

ggcugcugca acgacgaggg ccucgagugu gugcccaccg aggaguccaa caccaccacg      360

cagauuacgc ggaucaaacc ucaccaaggc cagcacauag gagagacgag cuuccuacag      420

cacaacaaac gugaacgcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaacguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agacgugaca agccgaggcg gugauaauag guuggagccu cgguggccac gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840


<210> 8
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Gly Gly Gly Ser 
1               


<210> 9
<211> 252
<212> PRT
<213> Homo sapiens

<400> 9
Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210> 10
<211> 349
<212> PRT
<213> Homo sapiens

<400> 10
Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210> 11
<211> 1207
<212> PRT
<213> Homo sapiens

<400> 11
Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210> 12
<211> 154
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu 
                85                  90                  95      


His Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile 
            100                 105                 110         


Ala Ile Gly Ile Gly Val Gly Leu Leu Leu Ser Gly Phe Leu Val Ile 
        115                 120                 125             


Phe Tyr Cys Tyr Ile Arg Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr 
    130                 135                 140                 


Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
145                 150                 


<210> 13
<211> 112
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu 
                85                  90                  95      


Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
            100                 105                 110         


<210> 14
<211> 103
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                  70                  75                  80  


Tyr Thr Gly Glu Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                  90                  95      


Ser Gly Glu Arg Arg Pro Leu 
            100             


<210> 15
<211> 103
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                  90                  95      


Ser Gly Glu Arg Arg Pro Leu 
            100             


<210> 16
<211> 94
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Leu Lys Leu 
65                  70                  75                  80  


Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
                85                  90                  


<210> 17
<211> 169
<212> PRT
<213> Homo sapiens

<400> 17
Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210> 18
<211> 155
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210> 19
<211> 288
<212> PRT
<213> Homo sapiens

<400> 19
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210> 20
<211> 194
<212> PRT
<213> Homo sapiens

<400> 20
Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210> 21
<211> 208
<212> PRT
<213> Homo sapiens

<400> 21
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210> 22
<211> 208
<212> PRT
<213> Homo sapiens

<400> 22
Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210> 23
<211> 158
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210> 24
<211> 137
<212> PRT
<213> Homo sapiens

<400> 24
Met Ile Thr Pro Thr Val Lys Met His Thr Met Ser Ser Ser His Leu 
1               5                   10                  15      


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
            20                  25                  30          


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
        35                  40                  45              


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
    50                  55                  60                  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
65                  70                  75                  80  


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
                85                  90                  95      


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
            100                 105                 110         


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
        115                 120                 125             


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
    130                 135         


<210> 25
<211> 195
<212> PRT
<213> Homo sapiens

<400> 25
Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 
145                 150                 155                 160 


Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 
                165                 170                 175     


Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 
            180                 185                 190         


Lys Gly Lys 
        195 


<210> 26
<211> 153
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210> 27
<211> 180
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210> 28
<211> 236
<212> PRT
<213> Homo sapiens

<400> 28
Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210> 29
<211> 382
<212> PRT
<213> Homo sapiens

<400> 29
Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
1               5                   10                  15      


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
            20                  25                  30          


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
        35                  40                  45              


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
    50                  55                  60                  


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
65                  70                  75                  80  


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
                85                  90                  95      


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
            100                 105                 110         


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
        115                 120                 125             


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
    130                 135                 140                 


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
145                 150                 155                 160 


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
                165                 170                 175     


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
            180                 185                 190         


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
        195                 200                 205             


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
    210                 215                 220                 


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
225                 230                 235                 240 


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
                245                 250                 255     


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
            260                 265                 270         


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
        275                 280                 285             


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
    290                 295                 300                 


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
305                 310                 315                 320 


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
                325                 330                 335     


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
            340                 345                 350         


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
        355                 360                 365             


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    370                 375                 380         


<210> 30
<211> 640
<212> PRT
<213> Homo sapiens

<400> 30
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210> 31
<211> 382
<212> PRT
<213> Homo sapiens

<400> 31
Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
1               5                   10                  15      


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
            20                  25                  30          


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
        35                  40                  45              


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
    50                  55                  60                  


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
65                  70                  75                  80  


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
                85                  90                  95      


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
            100                 105                 110         


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
        115                 120                 125             


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
    130                 135                 140                 


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
145                 150                 155                 160 


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
                165                 170                 175     


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
            180                 185                 190         


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
        195                 200                 205             


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
    210                 215                 220                 


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
225                 230                 235                 240 


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
                245                 250                 255     


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
            260                 265                 270         


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
        275                 280                 285             


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
    290                 295                 300                 


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
305                 310                 315                 320 


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
                325                 330                 335     


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
            340                 345                 350         


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
        355                 360                 365             


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    370                 375                 380         


<210> 32
<211> 422
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      


Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          


Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              


Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  


Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  


Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      


Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         


Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             


Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 


Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 


Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     


Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         


Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             


Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 


Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu 
                245                 250                 255     


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
            260                 265                 270         


Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn 
        275                 280                 285             


Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln 
    290                 295                 300                 


Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp 
                325                 330                 335     


Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Ala Thr Ser Thr 
            340                 345                 350         


Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys 
        355                 360                 365             


Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser 
    370                 375                 380                 


Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp 
385                 390                 395                 400 


Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro 
                405                 410                 415     


Phe Leu Ser Leu Pro Glu 
            420         


<210> 33
<211> 645
<212> PRT
<213> Homo sapiens

<400> 33
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210> 34
<211> 624
<212> PRT
<213> Homo sapiens

<400> 34
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr 
    130                 135                 140                 


Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys 
145                 150                 155                 160 


Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
                165                 170                 175     


Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            180                 185                 190         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe 
        195                 200                 205             


Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln 
    210                 215                 220                 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
225                 230                 235                 240 


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
                245                 250                 255     


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
            260                 265                 270         


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
        275                 280                 285             


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
    290                 295                 300                 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
305                 310                 315                 320 


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
                325                 330                 335     


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
            340                 345                 350         


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
        355                 360                 365             


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
    370                 375                 380                 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
385                 390                 395                 400 


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
                405                 410                 415     


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
            420                 425                 430         


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
        435                 440                 445             


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
    450                 455                 460                 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
465                 470                 475                 480 


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
                485                 490                 495     


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
            500                 505                 510         


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
        515                 520                 525             


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
    530                 535                 540                 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
545                 550                 555                 560 


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
                565                 570                 575     


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
            580                 585                 590         


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
        595                 600                 605             


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    610                 615                 620                 


<210> 35
<211> 607
<212> PRT
<213> Homo sapiens

<400> 35
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
145                 150                 155                 160 


Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn 
                165                 170                 175     


Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr 
            180                 185                 190         


Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys 
        195                 200                 205             


Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
    210                 215                 220                 


Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
225                 230                 235                 240 


Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
                245                 250                 255     


Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
            260                 265                 270         


Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
        275                 280                 285             


His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
    290                 295                 300                 


Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
305                 310                 315                 320 


Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
                325                 330                 335     


Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
            340                 345                 350         


Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
        355                 360                 365             


Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
    370                 375                 380                 


Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
385                 390                 395                 400 


Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
                405                 410                 415     


Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
            420                 425                 430         


Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
        435                 440                 445             


Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
    450                 455                 460                 


Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
465                 470                 475                 480 


Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
                485                 490                 495     


Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
            500                 505                 510         


Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
        515                 520                 525             


Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
    530                 535                 540                 


Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
545                 550                 555                 560 


Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
                565                 570                 575     


Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
            580                 585                 590         


Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
        595                 600                 605         


<210> 36
<211> 590
<212> PRT
<213> Homo sapiens

<400> 36
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
        115                 120                 125             


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
    130                 135                 140                 


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
145                 150                 155                 160 


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
                165                 170                 175     


His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
            180                 185                 190         


Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
        195                 200                 205             


Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
    210                 215                 220                 


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
225                 230                 235                 240 


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
                245                 250                 255     


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
            260                 265                 270         


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
        275                 280                 285             


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
    290                 295                 300                 


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
305                 310                 315                 320 


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
                325                 330                 335     


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
            340                 345                 350         


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
        355                 360                 365             


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
    370                 375                 380                 


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
385                 390                 395                 400 


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
                405                 410                 415     


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
            420                 425                 430         


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
        435                 440                 445             


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
    450                 455                 460                 


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
465                 470                 475                 480 


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
                485                 490                 495     


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
            500                 505                 510         


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
        515                 520                 525             


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
    530                 535                 540                 


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
545                 550                 555                 560 


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
                565                 570                 575     


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
            580                 585                 590 


<210> 37
<211> 637
<212> PRT
<213> Homo sapiens

<400> 37
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            420                 425                 430         


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        435                 440                 445             


Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    450                 455                 460                 


Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
465                 470                 475                 480 


Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                485                 490                 495     


Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            500                 505                 510         


Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        515                 520                 525             


Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    530                 535                 540                 


Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
545                 550                 555                 560 


Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                565                 570                 575     


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            580                 585                 590         


Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        595                 600                 605             


Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    610                 615                 620                 


Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635         


<210> 38
<211> 420
<212> PRT
<213> Homo sapiens

<400> 38
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg 
            420 


<210> 39
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccacc          57


<210> 40
<211> 54
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cacc             54


<210> 41
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
gccrcc                                                                   6


<210> 42
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
gccgcc                                                                   6


<210> 43
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
ccccggcgcc                                                              10


<210> 44
<211> 7
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
ccccggc                                                                  7


<210> 45
<211> 241
<212> PRT
<213> Homo sapiens

<400> 45
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro 
225                 230                 235                 240 


Glu 
    


<210> 46
<211> 207
<212> PRT
<213> Homo sapiens

<400> 46
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 


Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 


Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     


Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met 
            180                 185                 190         


Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
        195                 200                 205         


<210> 47
<211> 211
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys 
    210     


<210> 48
<211> 194
<212> PRT
<213> Homo sapiens

<400> 48
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser 
145                 150                 155                 160 


His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
                165                 170                 175     


Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
            180                 185                 190         


Cys Lys 
        


<210> 49
<211> 177
<212> PRT
<213> Homo sapiens

<400> 49
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 


Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 


Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     


Lys 
    


<210> 50
<211> 522
<212> PRT
<213> Homo sapiens

<400> 50
Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu 
        275                 280                 285             


Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu 
    290                 295                 300                 


Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys 
305                 310                 315                 320 


Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp 
                325                 330                 335     


Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile 
            340                 345                 350         


Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu 
        355                 360                 365             


Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val 
    370                 375                 380                 


Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser 
                405                 410                 415     


Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val 
            420                 425                 430         


Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro 
        435                 440                 445             


Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe 
    450                 455                 460                 


Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His 
465                 470                 475                 480 


Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg Asn Lys Ala His 
                485                 490                 495     


Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr His Leu Arg Ser 
            500                 505                 510         


Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
        515                 520         


<210> 51
<211> 483
<212> PRT
<213> Homo sapiens

<400> 51
Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu 
        275                 280                 285             


Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu 
    290                 295                 300                 


Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys 
305                 310                 315                 320 


Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp 
                325                 330                 335     


Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile 
            340                 345                 350         


Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu 
        355                 360                 365             


Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val 
    370                 375                 380                 


Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser 
                405                 410                 415     


Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val 
            420                 425                 430         


Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro 
        435                 440                 445             


Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe 
    450                 455                 460                 


Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His 
465                 470                 475                 480 


Ser Glu Arg 
            


<210> 52
<211> 700
<212> PRT
<213> Homo sapiens

<400> 52
Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu 
        275                 280                 285             


Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu 
    290                 295                 300                 


Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys 
305                 310                 315                 320 


Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp 
                325                 330                 335     


Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile 
            340                 345                 350         


Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu 
        355                 360                 365             


Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val 
    370                 375                 380                 


Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser 
                405                 410                 415     


Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val 
            420                 425                 430         


Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro 
        435                 440                 445             


Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe 
    450                 455                 460                 


Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His 
465                 470                 475                 480 


Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser Pro 
                485                 490                 495     


Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu Met 
            500                 505                 510         


Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala Val 
        515                 520                 525             


Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro Pro 
    530                 535                 540                 


Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser Ser 
545                 550                 555                 560 


Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser Pro 
                565                 570                 575     


Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu 
            580                 585                 590         


Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala Lys 
        595                 600                 605             


Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp Ser 
    610                 615                 620                 


Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu 
625                 630                 635                 640 


Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala 
                645                 650                 655     


Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg Thr 
            660                 665                 670         


Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg Leu 
        675                 680                 685             


Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    690                 695                 700 


<210> 53
<211> 462
<212> PRT
<213> Homo sapiens

<400> 53
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg 
            420                 425                 430         


Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr 
        435                 440                 445             


His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 460         


<210> 54
<211> 459
<212> PRT
<213> Homo sapiens

<400> 54
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg Asn Lys Ala 
            420                 425                 430         


His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr His Leu Arg 
        435                 440                 445             


Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 


<210> 55
<211> 308
<212> PRT
<213> Homo sapiens

<400> 55
Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly 
    50                  55                  60                  


Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys 
65                  70                  75                  80  


Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
                85                  90                  95      


Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            100                 105                 110         


Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu 
        115                 120                 125             


Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His 
    130                 135                 140                 


Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser 
145                 150                 155                 160 


Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr 
                165                 170                 175     


Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr 
            180                 185                 190         


Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser 
        195                 200                 205             


Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn 
    210                 215                 220                 


Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly 
225                 230                 235                 240 


Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu 
                245                 250                 255     


Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg His Asn Leu 
            260                 265                 270         


Ile Ala Glu Leu Arg Arg Asn Lys Ala His Arg Ser Lys Cys Met Gln 
        275                 280                 285             


Ile Gln Leu Ser Ala Thr His Leu Arg Ser Ser Ser Ile Pro His Leu 
    290                 295                 300                 


Gly Phe Ile Leu 
305             


<210> 56
<211> 296
<212> PRT
<213> Homo sapiens

<400> 56
Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser 
        275                 280                 285             


Thr Pro Phe Leu Ser Leu Pro Glu 
    290                 295     


<210> 57
<211> 483
<212> PRT
<213> Homo sapiens

<400> 57
Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly 
    50                  55                  60                  


Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys Ala Glu Glu 
65                  70                  75                  80  


Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu 
                85                  90                  95      


Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys 
            100                 105                 110         


Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu 
        115                 120                 125             


Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro 
    130                 135                 140                 


Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val 
145                 150                 155                 160 


Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser 
                165                 170                 175     


Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln 
            180                 185                 190         


Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser 
        195                 200                 205             


Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His 
    210                 215                 220                 


Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly 
225                 230                 235                 240 


Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp 
                245                 250                 255     


Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr 
            260                 265                 270         


Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro 
        275                 280                 285             


Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val 
    290                 295                 300                 


Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro 
305                 310                 315                 320 


Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His 
                325                 330                 335     


His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser 
            340                 345                 350         


Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr 
        355                 360                 365             


Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu 
    370                 375                 380                 


Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala 
385                 390                 395                 400 


Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser 
                405                 410                 415     


Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu 
            420                 425                 430         


Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe 
        435                 440                 445             


Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln 
    450                 455                 460                 


Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro 
465                 470                 475                 480 


Ile Ala Val 
            


<210> 58
<211> 170
<212> PRT
<213> Homo sapiens

<400> 58
Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro 
    130                 135                 140                 


Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys 
145                 150                 155                 160 


His Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 170 


<210> 59
<211> 149
<212> PRT
<213> Homo sapiens

<400> 59
Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Cys Gly Asp 
    130                 135                 140                 


Ala Val Pro Arg Arg 
145                 


<210> 60
<211> 169
<212> PRT
<213> Homo sapiens

<400> 60
Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Trp Ala Leu Ser Ala Gly Asn 
            20                  25                  30          


Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg 
        35                  40                  45              


Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr 
    50                  55                  60                  


Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu 
65                  70                  75                  80  


Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro Val 
                85                  90                  95      


Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp 
            100                 105                 110         


Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu 
        115                 120                 125             


Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro Lys 
    130                 135                 140                 


Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys His 
145                 150                 155                 160 


Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 


<210> 61
<211> 1089
<212> PRT
<213> Homo sapiens

<400> 61
Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210> 62
<211> 807
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Gly Trp Ala Gly Gly Val Gly Thr Arg Cys 
    770                 775                 780                 


Gln Arg Asn Leu Ser His Ala Gln Ala Gln Ala Leu Leu Ala Gly Arg 
785                 790                 795                 800 


Pro Leu Leu Ser Gly Leu Pro 
                805         


<210> 63
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 63
Met Leu Pro Arg Leu Val Leu Asn Ser Trp Ala Gln Met Ile Cys Leu 
1               5                   10                  15      


Pro Gln Leu Pro Lys Phe Pro Arg Ala Met Gly Thr Ser His Pro Ala 
            20                  25                  30          


Phe Leu Val Leu Gly Cys Leu Leu Thr Gly Leu Ser Leu Ile Leu Cys 
        35                  40                  45              


Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
    50                  55                  60                  


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
65                  70                  75                  80  


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
                85                  90                  95      


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
            100                 105                 110         


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
        115                 120                 125             


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
    130                 135                 140                 


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
145                 150                 155                 160 


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
                165                 170                 175     


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
            180                 185                 190         


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
        195                 200                 205             


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
    210                 215                 220                 


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp 
225                 230                 235                 240 


Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile 
                245                 250                 255     


Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp 
            260                 265                 270         


Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu 
        275                 280                 285             


Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
    290                 295                 300                 


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
305                 310                 315                 320 


Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser Val His Glu 
                325                 330                 335     


Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
            340                 345                 350         


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
        355                 360                 365             


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
    370                 375                 380                 


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
385                 390                 395                 400 


Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
                405                 410                 415     


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
            420                 425                 430         


Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp 
        435                 440                 445             


His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly 
    450                 455                 460                 


Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys 
465                 470                 475                 480 


Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn 
                485                 490                 495     


Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg 
            500                 505                 510         


Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala 
        515                 520                 525             


Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro 
    530                 535                 540                 


Thr Leu Arg Ser Glu Leu Thr Val Ala Ala Ala Val Leu Val Leu Leu 
545                 550                 555                 560 


Val Ile Val Ile Ile Ser Leu Ile Val Leu Val Val Ile Trp Lys Gln 
                565                 570                 575     


Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile Glu Ser Ile Ser Pro 
            580                 585                 590         


Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp 
        595                 600                 605             


Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val Leu Gly Arg Val Leu 
    610                 615                 620                 


Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly Thr Ala Tyr Gly Leu 
625                 630                 635                 640 


Ser Arg Ser Gln Pro Val Met Lys Val Ala Val Lys Met Leu Lys Pro 
                645                 650                 655     


Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile 
            660                 665                 670         


Met Thr His Leu Gly Pro His Leu Asn Ile Val Asn Leu Leu Gly Ala 
        675                 680                 685             


Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Phe Tyr 
    690                 695                 700                 


Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg Asp Ser Phe Leu Ser 
705                 710                 715                 720 


His His Pro Glu Lys Pro Lys Lys Glu Leu Asp Ile Phe Gly Leu Asn 
                725                 730                 735     


Pro Ala Asp Glu Ser Thr Arg Ser Tyr Val Ile Leu Ser Phe Glu Asn 
            740                 745                 750         


Asn Gly Asp Tyr Met Asp Met Lys Gln Ala Asp Thr Thr Gln Tyr Val 
        755                 760                 765             


Pro Met Leu Glu Arg Lys Glu Val Ser Lys Tyr Ser Asp Ile Gln Arg 
    770                 775                 780                 


Ser Leu Tyr Asp Arg Pro Ala Ser Tyr Lys Lys Lys Ser Met Leu Asp 
785                 790                 795                 800 


Ser Glu Val Lys Asn Leu Leu Ser Asp Asp Asn Ser Glu Gly Leu Thr 
                805                 810                 815     


Leu Leu Asp Leu Leu Ser Phe Thr Tyr Gln Val Ala Arg Gly Met Glu 
            820                 825                 830         


Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Leu Ala Gln Gly Lys Ile Val Lys Ile Cys Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Asp Ile Met His Asp Ser Asn Tyr Val Ser Lys Gly Ser Thr 
865                 870                 875                 880 


Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Asn Leu 
                885                 890                 895     


Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
            900                 905                 910         


Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly Met Met Val Asp Ser 
        915                 920                 925             


Thr Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg Met Ala Lys Pro Asp 
    930                 935                 940                 


His Ala Thr Ser Glu Val Tyr Glu Ile Met Val Lys Cys Trp Asn Ser 
945                 950                 955                 960 


Glu Pro Glu Lys Arg Pro Ser Phe Tyr His Leu Ser Glu Ile Val Glu 
                965                 970                 975     


Asn Leu Leu Pro Gly Gln Tyr Lys Lys Ser Tyr Glu Lys Ile His Leu 
            980                 985                 990         


Asp Phe Leu Lys Ser Asp His Pro  Ala Val Ala Arg Met  Arg Val Asp 
        995                 1000                 1005             


Ser Asp  Asn Ala Tyr Ile Gly  Val Thr Tyr Lys Asn  Glu Glu Asp 
    1010                 1015                 1020             


Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp Glu Gln  Arg Leu Ser 
    1025                 1030                 1035             


Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro Asp Ile  Asp Pro Val 
    1040                 1045                 1050             


Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn Arg His  Ser Ser Gln 
    1055                 1060                 1065             


Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly Ser Ser  Ser Ser Thr 
    1070                 1075                 1080             


Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu Asp Ile  Asp Met Met 
    1085                 1090                 1095             


Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu Val Glu  Asp Ser Phe 
    1100                 1105                 1110             


Leu 
    


<210> 64
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 64
Met Gly Phe Ala Glu Thr Ile Arg Lys Phe Pro Arg Ala Met Gly Thr 
1               5                   10                  15      


Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr Gly Leu Ser 
            20                  25                  30          


Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn 
        35                  40                  45              


Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly 
    50                  55                  60                  


Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser 
65                  70                  75                  80  


Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr 
                85                  90                  95      


Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr 
            100                 105                 110         


Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg 
        115                 120                 125             


His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu 
    130                 135                 140                 


Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile 
145                 150                 155                 160 


Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn 
                165                 170                 175     


Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn 
            180                 185                 190         


Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly 
        195                 200                 205             


Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr 
    210                 215                 220                 


Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser 
225                 230                 235                 240 


Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val 
                245                 250                 255     


Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr 
            260                 265                 270         


Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu 
        275                 280                 285             


Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala 
    290                 295                 300                 


Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile 
305                 310                 315                 320 


Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln 
                325                 330                 335     


Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val Val Glu Val 
            340                 345                 350         


Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr 
        355                 360                 365             


Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln 
    370                 375                 380                 


Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu 
385                 390                 395                 400 


Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys 
                405                 410                 415     


Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp 
            420                 425                 430         


Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys 
        435                 440                 445             


Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys 
    450                 455                 460                 


Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn 
465                 470                 475                 480 


Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr 
                485                 490                 495     


Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val 
            500                 505                 510         


Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys 
        515                 520                 525             


Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala Ala Ala Val 
    530                 535                 540                 


Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val Leu Val Val 
545                 550                 555                 560 


Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile Glu 
                565                 570                 575     


Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln 
            580                 585                 590         


Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val Leu 
        595                 600                 605             


Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly Thr 
    610                 615                 620                 


Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val Ala Val Lys 
625                 630                 635                 640 


Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser 
                645                 650                 655     


Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn Ile Val Asn 
            660                 665                 670         


Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr Glu 
        675                 680                 685             


Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg Asp 
    690                 695                 700                 


Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu Leu Asp Ile 
705                 710                 715                 720 


Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr Val Ile Leu 
                725                 730                 735     


Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln Ala Asp Thr 
            740                 745                 750         


Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser Lys Tyr Ser 
        755                 760                 765             


Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr Lys Lys Lys 
    770                 775                 780                 


Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp Asp Asn Ser 
785                 790                 795                 800 


Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr Gln Val Ala 
                805                 810                 815     


Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu 
            820                 825                 830         


Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val Lys Ile Cys 
        835                 840                 845             


Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn Tyr Val Ser 
    850                 855                 860                 


Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile 
865                 870                 875                 880 


Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly Ile 
                885                 890                 895     


Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly Met 
            900                 905                 910         


Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg Met 
        915                 920                 925             


Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile Met Val Lys 
    930                 935                 940                 


Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr His Leu Ser 
945                 950                 955                 960 


Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys Ser Tyr Glu 
                965                 970                 975     


Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala Val Ala Arg 
            980                 985                 990         


Met Arg Val Asp Ser Asp Asn Ala  Tyr Ile Gly Val Thr  Tyr Lys Asn 
        995                 1000                 1005             


Glu Glu  Asp Lys Leu Lys Asp  Trp Glu Gly Gly Leu  Asp Glu Gln 
    1010                 1015                 1020             


Arg Leu  Ser Ala Asp Ser Gly  Tyr Ile Ile Pro Leu  Pro Asp Ile 
    1025                 1030                 1035             


Asp Pro  Val Pro Glu Glu Glu  Asp Leu Gly Lys Arg  Asn Arg His 
    1040                 1045                 1050             


Ser Ser  Gln Thr Ser Glu Glu  Ser Ala Ile Glu Thr  Gly Ser Ser 
    1055                 1060                 1065             


Ser Ser  Thr Phe Ile Lys Arg  Glu Asp Glu Thr Ile  Glu Asp Ile 
    1070                 1075                 1080             


Asp Met  Met Asp Asp Ile Gly  Ile Asp Ser Ser Asp  Leu Val Glu 
    1085                 1090                 1095             


Asp Ser  Phe Leu 
    1100         


<210> 65
<211> 241
<212> PRT
<213> Homo sapiens

<400> 65
Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210> 66
<211> 226
<212> PRT
<213> Homo sapiens

<400> 66
Met Phe Ile Met Gly Leu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu 
1               5                   10                  15      


Met Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu 
            20                  25                  30          


Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn 
        35                  40                  45              


Met Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly 
    50                  55                  60                  


Arg Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala 
65                  70                  75                  80  


Glu Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile 
                85                  90                  95      


Asp Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val 
            100                 105                 110         


Gln Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro 
        115                 120                 125             


Thr Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val 
    130                 135                 140                 


Arg Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His 
145                 150                 155                 160 


Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg 
                165                 170                 175     


Ser Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg 
            180                 185                 190         


Val Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His 
        195                 200                 205             


Arg Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu 
    210                 215                 220                 


Gly Ala 
225     


<210> 67
<211> 160
<212> PRT
<213> Homo sapiens

<400> 67
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210> 68
<211> 159
<212> PRT
<213> Homo sapiens

<400> 68
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210> 69
<211> 165
<212> PRT
<213> Homo sapiens

<400> 69
Met Phe Lys Ile Gly Arg Gly Ala Leu Asp Leu Phe Ser Glu Leu Leu 
1               5                   10                  15      


Ser Phe Gly Gly Ile Val Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser 
            20                  25                  30          


Thr Ser Pro Leu Ser Ala Asp Pro Pro Val Ala Ala Ala Val Val Ser 
        35                  40                  45              


His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys Phe His Gly 
    50                  55                  60                  


Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
65                  70                  75                  80  


Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala Val 
                85                  90                  95      


Val Ala Ala Ser Gln Lys Lys Gln Ala Ile Thr Ala Leu Val Val Val 
            100                 105                 110         


Ser Ile Val Ala Leu Ala Val Leu Ile Ile Thr Cys Val Leu Ile His 
        115                 120                 125             


Cys Cys Gln Val Arg Lys His Cys Glu Trp Cys Arg Ala Leu Ile Cys 
    130                 135                 140                 


Arg His Glu Lys Pro Ser Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys 
145                 150                 155                 160 


His Ser Glu Thr Val 
                165 


<210> 70
<211> 165
<212> PRT
<213> Homo sapiens

<400> 70
Met Phe Lys Ile Gly Arg Gly Ala Leu Asp Leu Phe Ser Glu Leu Leu 
1               5                   10                  15      


Ser Phe Gly Gly Ile Val Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser 
            20                  25                  30          


Thr Ser Pro Leu Ser Asp Pro Pro Val Ala Ala Ala Val Val Ser His 
        35                  40                  45              


Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys Phe His Gly Thr 
    50                  55                  60                  


Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser 
65                  70                  75                  80  


Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala Val Val 
                85                  90                  95      


Ala Ala Ser Gln Lys Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser 
            100                 105                 110         


Ile Val Ala Leu Ala Val Leu Ile Ile Thr Cys Val Leu Ile His Cys 
        115                 120                 125             


Cys Gln Val Arg Lys His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg 
    130                 135                 140                 


His Glu Lys Pro Ser Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His 
145                 150                 155                 160 


Ser Glu Thr Val Val 
                165 


<210> 71
<211> 390
<212> PRT
<213> Homo sapiens

<400> 71
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 72
<211> 442
<212> PRT
<213> Homo sapiens

<400> 72
Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210> 73
<211> 414
<212> PRT
<213> Homo sapiens

<400> 73
Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210> 74
<211> 419
<212> PRT
<213> Homo sapiens

<400> 74
Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
145                 150                 155                 160 


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
                165                 170                 175     


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
            180                 185                 190         


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
        195                 200                 205             


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
    210                 215                 220                 


Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn 
225                 230                 235                 240 


Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys 
                245                 250                 255     


Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser 
            260                 265                 270         


Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu 
        275                 280                 285             


Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys 
    290                 295                 300                 


Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys 
305                 310                 315                 320 


Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu 
                325                 330                 335     


Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro 
            340                 345                 350         


Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys 
        355                 360                 365             


Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr 
    370                 375                 380                 


Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser 
385                 390                 395                 400 


Tyr Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro 
                405                 410                 415     


Gln Met Ser 
            


<210> 75
<211> 132
<212> PRT
<213> Homo sapiens

<400> 75
Met Lys Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly 
1               5                   10                  15      


Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala 
            20                  25                  30          


Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys Lys 
        35                  40                  45              


Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg Cys Cys 
    50                  55                  60                  


Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp Thr Pro Asn 
65                  70                  75                  80  


Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val Thr Tyr Gly Gln Cys 
                85                  90                  95      


Leu Met Leu Asn Pro Pro Asn Phe Cys Glu Met Asp Gly Gln Cys Lys 
            100                 105                 110         


Arg Asp Leu Lys Cys Cys Met Gly Met Cys Gly Lys Ser Cys Val Ser 
        115                 120                 125             


Pro Val Lys Ala 
    130         


<210> 76
<211> 207
<212> PRT
<213> Homo sapiens

<400> 76
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210> 77
<211> 204
<212> PRT
<213> Homo sapiens

<400> 77
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210> 78
<211> 171
<212> PRT
<213> Homo sapiens

<400> 78
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 
            100                 105                 110         


Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210> 79
<211> 168
<212> PRT
<213> Homo sapiens

<400> 79
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr 
                85                  90                  95      


Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 
            100                 105                 110         


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 
        115                 120                 125             


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
    130                 135                 140                 


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 
145                 150                 155                 160 


Val Leu Arg His Leu Ala Gln Pro 
                165             


<210> 80
<211> 144
<212> PRT
<213> Homo sapiens

<400> 80
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 81
<211> 728
<212> PRT
<213> Homo sapiens

<400> 81
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210> 82
<211> 290
<212> PRT
<213> Homo sapiens

<400> 82
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Glu Thr 
    290 


<210> 83
<211> 723
<212> PRT
<213> Homo sapiens

<400> 83
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met 
        275                 280                 285             


Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln 
    290                 295                 300                 


Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro 
305                 310                 315                 320 


Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro 
                325                 330                 335     


Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg 
        355                 360                 365             


Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln 
    370                 375                 380                 


Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln 
385                 390                 395                 400 


Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp 
                405                 410                 415     


Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys 
    450                 455                 460                 


Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile 
465                 470                 475                 480 


Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr 
                485                 490                 495     


Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His 
            500                 505                 510         


Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg 
        515                 520                 525             


Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly 
    530                 535                 540                 


Ile His Asp Val His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu 
545                 550                 555                 560 


Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu 
                565                 570                 575     


Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile 
            580                 585                 590         


Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser 
        595                 600                 605             


Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu 
    610                 615                 620                 


Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His 
625                 630                 635                 640 


His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala 
                645                 650                 655     


Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu 
            660                 665                 670         


Val Cys Glu Gln His Lys Met Arg Met Val Leu Gly Val Ile Val Pro 
        675                 680                 685             


Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val 
    690                 695                 700                 


Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val 
705                 710                 715                 720 


Pro Gln Ser 
            


<210> 84
<211> 285
<212> PRT
<213> Homo sapiens

<400> 84
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Glu Thr 
        275                 280                 285 


<210> 85
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 85
gggaaauaag agagaaaaga agaguaagaa gaaauauaag a                           41


<210> 86
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Gly Gly Gly Gly Ser 
1               5   


<210> 87
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
ccrccaugg                                                                9


<210> 88
<211> 92
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
ucaagcuuuu ggacccucgu acagaagcua auacgacuca cuauagggaa auaagagaga       60

aaagaagagu aagaagaaau auaagagcca cc                                     92


<210> 89
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 90
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210> 91
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 92
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 92
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210> 93
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 93
gggaauuaac agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 94
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 94
gggaaauuag acagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 95
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 95
gggaaauaag agaguaaaga acaguaagaa gaaauauaag agccacc                     47


<210> 96
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 96
gggaaaaaag agagaaaaga agacuaagaa gaaauauaag agccacc                     47


<210> 97
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 97
gggaaauaag agagaaaaga agaguaagaa gauauauaag agccacc                     47


<210> 98
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 98
gggaaauaag agacaaaaca agaguaagaa gaaauauaag agccacc                     47


<210> 99
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 99
gggaaauuag agaguaaaga acaguaagua gaauuaaaag agccacc                     47


<210> 100
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 100
gggaaauaag agagaauaga agaguaagaa gaaauauaag agccacc                     47


<210> 101
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 101
gggaaauaag agagaaaaga agaguaagaa gaaaauuaag agccacc                     47


<210> 102
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 102
gggaaauaag agagaaaaga agaguaagaa gaaauuuaag agccacc                     47


<210> 103

<400> 103
000


<210> 104
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 104
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 105
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 105
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 106
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 106
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuuccauaaa guaggaaaca       60

cuacaugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 107
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 107
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagucc       60

auaaaguagg aaacacuaca ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 108
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 108
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu ucuccauaaa guaggaaaca cuacacugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 109
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 109
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 110
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 110
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaaguucca uaaaguagga      120

aacacuacac ugagugggcg gc                                               142


<210> 111
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 111
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 112
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 112
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 113

<400> 113
000


<210> 114
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 114
gacagugcag ucacccauaa aguagaaagc acuacuaaca gcacuggagg guguaguguu       60

uccuacuuua uggaugagug uacugug                                           87


<210> 115
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 115
uguaguguuu ccuacuuuau gga                                               23


<210> 116
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 116
uccauaaagu aggaaacacu aca                                               23


<210> 117
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 117
cauaaaguag aaagcacuac u                                                 21


<210> 118
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 118
aguagugcuu ucuacuuuau g                                                 21


<210> 119
<211> 85
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 119
cgcuggcgac gggacauuau uacuuuuggu acgcgcugug acacuucaaa cucguaccgu       60

gaguaauaau gcgccgucca cggca                                             85


<210> 120
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 120
ucguaccgug aguaauaaug cg                                                22


<210> 121
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 121
cgcauuauua cucacgguac ga                                                22


<210> 122
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 122
cauuauuacu uuugguacgc g                                                 21


<210> 123
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 123
cgcguaccaa aaguaauaau g                                                 21


<210> 124
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 124
ugauaauag                                                                9


<210> 125
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 125
ugauaguaa                                                                9


<210> 126
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 126
uaaugauag                                                                9


<210> 127
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 127
ugauaauaa                                                                9


<210> 128
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 128
ugauaguag                                                                9


<210> 129
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 129
uaaugauga                                                                9


<210> 130
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 130
uaauaguag                                                                9


<210> 131
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 131
ugaugauga                                                                9


<210> 132
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 132
uaauaauaa                                                                9


<210> 133
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 133
uaguaguag                                                                9


<210> 134
<211> 133
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 134
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccu ccauaaagua ggaaacacua caguggucuu ugaauaaagu      120

cugagugggc ggc                                                         133


<210> 135
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 135
ccucugaaau ucaguucuuc ag                                                22


<210> 136
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 136
ugagaacuga auuccauggg uu                                                22


<210> 137
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 137
cuccuacaua uuagcauuaa ca                                                22


<210> 138
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 138
uuaaugcuaa ucgugauagg ggu                                               23


<210> 139
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 139
ccaguauuaa cugugcugcu ga                                                22


<210> 140
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 140
uagcagcacg uaaauauugg cg                                                22


<210> 141
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 141
caacaccagu cgaugggcug u                                                 21


<210> 142
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 142
uagcuuauca gacugauguu ga                                                22


<210> 143
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 143
ugucaguuug ucaaauaccc ca                                                22


<210> 144
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 144
cguguauuug acaagcugag uu                                                22


<210> 145
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 145
uggcucaguu cagcaggaac ag                                                22


<210> 146
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 146
ugccuacuga gcugauauca gu                                                22


<210> 147
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 147
uucacagugg cuaaguuccg c                                                 21


<210> 148
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 148
agggcuuagc ugcuugugag ca                                                22


<210> 149
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 149
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guaccccccg cauuauuacu cacgguacga guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 150
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 150
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210> 151
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 151
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 152
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 152
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 153
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 153
uuaaugcuaa uugugauagg ggu                                               23


<210> 154
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 154
accccuauca caauuagcau uaa                                               23


<210> 155
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 155
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccuccaua aaguaggaaa cacuacagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 156
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 156
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccag uagugcuuuc uacuuuaugg uggucuuuga      120

auaaagucug agugggcggc                                                  140


<210> 157
<211> 182
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 157
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggcca guagugcuuu cuacuuuaug uccccccagc cccuccuccc cuuccugcac      120

ccguaccccc aguagugcuu ucuacuuuau gguggucuuu gaauaaaguc ugagugggcg      180

gc                                                                     182


<210> 158
<211> 184
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 158
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggccu ccauaaagua ggaaacacua caucccccca gccccuccuc cccuuccugc      120

acccguaccc ccaguagugc uuucuacuuu augguggucu uugaauaaag ucugaguggg      180

cggc                                                                   184


<210> 159
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 159
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccac cccuaucaca auuagcauua aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 160
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 160
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc augcuucuug       60

ccccuugggc caccccuauc acaauuagca uuaauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 161
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 161
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 162
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 162
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 163
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 163
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 164
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 164
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cauaaaguag       60

gaaacacuac auccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 165
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 165
gggaaauaag aguccauaaa guaggaaaca cuacaagaaa agaagaguaa gaagaaauau       60

aagagccacc                                                              70


<210> 166
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 166
gggaaauaag agagaaaaga agaguaaucc auaaaguagg aaacacuaca gaagaaauau       60

aagagccacc                                                              70


<210> 167
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 167
gggaaauaag agagaaaaga agaguaagaa gaaauauaau ccauaaagua ggaaacacua       60

cagagccacc                                                              70


<210> 168
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 168
accccuauca caauuagcau uaa                                               23


<210> 169
<211> 181
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 169
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggcca guagugcuuu cuacuuuaug uccccccagc cccucucccc uuccugcacc      120

cguaccccca guagugcuuu cuacuuuaug guggucuuug aauaaagucu gagugggcgg      180

c                                                                      181


<210> 170
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 170
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuuccauaaa guaggaaaca       60

cuacaugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 171
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 171
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagucc       60

auaaaguagg aaacacuaca ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 172
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 172
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu ucuccauaaa guaggaaaca cuacacugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 173
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 173
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaaguucca uaaaguagga      120

aacacuacac ugagugggcg gc                                               142


<210> 174
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 174
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 175
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 175
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210> 176
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 176
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 177
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 177
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guaccccccg cauuauuacu cacgguacga guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 178
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 178
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccuccaua aaguaggaaa cacuacagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 179
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 179
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 180
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 180
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 181
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 181
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cauaaaguag       60

gaaacacuac auccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 182
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 182
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccac cccuaucaca auuagcauua aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 183
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 183
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc caccccuauc acaauuagca uuaauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 184
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 184
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 185
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 185
attgggcacc cgtaaggg                                                     18


<210> 186
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 186
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 187
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 187
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 188
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 188
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 189
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 189
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 190
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20) 
<223> /note="This sequence may encompass 2-5 'Gly Gly Gly Ser'
      repeating units"

<400> 190
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 191
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 191
ggaagcggag cuacuaacuu cagccugcug aagcaggcug gagacgugga ggagaacccu       60

ggaccu                                                                  66


<210> 192
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 192
uccggacuca gauccgggga ucucaaaauu gucgcuccug ucaaacaaac ucuuaacuuu       60

gauuuacuca aacuggctgg ggauguagaa agcaauccag gtccacuc                   108


<210> 193
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 193
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 194
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 194
aggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccacc          57


<210> 195
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 195
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccca aacaccauug ucacacucca guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 196
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 196
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccca aacaccauug ucacacucca guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 197
<211> 210
<212> PRT
<213> Homo sapiens

<400> 197
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Gly Lys 
    210 


<210> 198
<211> 271
<212> PRT
<213> Homo sapiens

<400> 198
Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210> 199
<211> 269
<212> PRT
<213> Homo sapiens

<400> 199
Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210> 200
<211> 212
<212> PRT
<213> Homo sapiens

<400> 200
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210> 201
<211> 136
<212> PRT
<213> Homo sapiens

<400> 201
Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
1               5                   10                  15      


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            20                  25                  30          


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        35                  40                  45              


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    50                  55                  60                  


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
65                  70                  75                  80  


Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn 
                85                  90                  95      


Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp 
            100                 105                 110         


Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Ser Leu Arg Ala Leu Arg Gln Met 
    130                 135     


<210> 202
<211> 99
<212> PRT
<213> Homo sapiens

<400> 202
Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210> 203
<211> 95
<212> PRT
<213> Homo sapiens

<400> 203
Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg 
                85                  90                  95  


<210> 204
<211> 178
<212> PRT
<213> Homo sapiens

<400> 204
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 205
<211> 233
<212> PRT
<213> Homo sapiens

<400> 205
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210> 206
<211> 99
<212> PRT
<213> Homo sapiens

<400> 206
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210> 207
<211> 89
<212> PRT
<213> Homo sapiens

<400> 207
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  


<210> 208
<211> 93
<212> PRT
<213> Homo sapiens

<400> 208
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210> 209
<211> 140
<212> PRT
<213> Homo sapiens

<400> 209
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Asn Leu Ile Ser Ala Ala Pro Ala 
                85                  90                  95      


Gly Lys Arg Val Ile Ala Gly Ala Arg Ala Leu His Pro Ser Pro Pro 
            100                 105                 110         


Arg Ala Cys Pro Thr Ala Arg Ala Leu Cys Glu Ile Arg Leu Trp Pro 
        115                 120                 125             


Pro Pro Glu Trp Ser Trp Pro Ser Pro Gly Asp Val 
    130                 135                 140 


<210> 210
<211> 119
<212> PRT
<213> Homo sapiens

<400> 210
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val 
                85                  90                  95      


Gly Lys Lys Glu Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys 
            100                 105                 110         


Ala Ala Gln Lys Arg Lys Asn 
        115                 


<210> 211
<211> 103
<212> PRT
<213> Homo sapiens

<400> 211
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Tyr Cys Thr Cys Leu Ile Arg Val Ser Phe 
        35                  40                  45              


His Gly Ala Thr Pro Leu Thr Gln Gly Ser Trp Val Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Cys Ala Gly Gly Glu Thr Gly Leu Arg Glu Pro Gly Pro Met Val 
65                  70                  75                  80  


Ser Pro Arg Val Glu Ser His Gln Glu Gly Arg Leu Gly Val Pro Gly 
                85                  90                  95      


Pro Val Asn Leu Gly Lys Ala 
            100             


<210> 212
<211> 191
<212> PRT
<213> Homo sapiens

<400> 212
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210> 213
<211> 1069
<212> PRT
<213> Homo sapiens

<400> 213
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr 
    


<210> 214
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 214
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210> 215
<211> 1466
<212> PRT
<213> Homo sapiens

<400> 215
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val His 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210> 216
<211> 1669
<212> PRT
<213> Homo sapiens

<400> 216
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Thr  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Thr Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Thr  Pro Gly Pro 
    1130                 1135                 1140             


Thr Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Thr Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Thr Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Thr Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Thr Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Thr Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Thr Arg  His Ser Gln Thr Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Thr Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Thr Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Thr  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Thr Pro Ser Thr Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Thr His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Thr 
    


<210> 217
<211> 1712
<212> PRT
<213> Homo sapiens

<400> 217
Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210> 218
<211> 1838
<212> PRT
<213> Homo sapiens

<400> 218
Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210> 219
<211> 1838
<212> PRT
<213> Homo sapiens

<400> 219
Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ser  Lys Met Ala Arg Trp  Pro Lys Glu 
    1685                 1690                 1695             


Gln Pro  Ser Thr Trp Tyr Ser  Gln Tyr Lys Arg Gly  Ser Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210> 220
<211> 1499
<212> PRT
<213> Homo sapiens

<400> 220
Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
1               5                   10                  15      


Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
            20                  25                  30          


Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
        35                  40                  45              


Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
    50                  55                  60                  


Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
65                  70                  75                  80  


Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                85                  90                  95      


Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
            100                 105                 110         


Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
        115                 120                 125             


Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
    130                 135                 140                 


Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
145                 150                 155                 160 


Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                165                 170                 175     


Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
            180                 185                 190         


Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
        195                 200                 205             


Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
    210                 215                 220                 


Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
225                 230                 235                 240 


Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                245                 250                 255     


Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
            260                 265                 270         


Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
        275                 280                 285             


Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
    290                 295                 300                 


Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
305                 310                 315                 320 


Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                325                 330                 335     


Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
            340                 345                 350         


Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
        355                 360                 365             


Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
    370                 375                 380                 


Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
385                 390                 395                 400 


Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                405                 410                 415     


Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly 
            420                 425                 430         


Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
        435                 440                 445             


Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg 
    450                 455                 460                 


Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro 
                485                 490                 495     


Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val 
            500                 505                 510         


Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
        515                 520                 525             


Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu 
    530                 535                 540                 


Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro 
545                 550                 555                 560 


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                565                 570                 575     


Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala 
            580                 585                 590         


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg 
        595                 600                 605             


Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln 
625                 630                 635                 640 


Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val 
                645                 650                 655     


Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly 
            660                 665                 670         


Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
        675                 680                 685             


Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val 
    690                 695                 700                 


Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly 
705                 710                 715                 720 


Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly 
                725                 730                 735     


His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro 
            740                 745                 750         


Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
        755                 760                 765             


Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu 
    770                 775                 780                 


Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro 
785                 790                 795                 800 


Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly 
                805                 810                 815     


Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn 
            820                 825                 830         


Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala 
        835                 840                 845             


Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly 
    850                 855                 860                 


Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu 
865                 870                 875                 880 


Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys 
                885                 890                 895     


Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
            900                 905                 910         


Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro 
        915                 920                 925             


Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg 
    930                 935                 940                 


Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln 
                965                 970                 975     


Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg 
            980                 985                 990         


Gly Ile Val Gly Met Pro Gly Gln  Arg Gly Glu Arg Gly  Met Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Pro Ala Gly Thr  Pro Gly Lys Val Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Thr  Gly Asp Lys Gly Pro  Pro Gly Pro Val Gly  Pro Pro Gly 
    1025                 1030                 1035             


Ser Asn  Gly Pro Val Gly Glu  Pro Gly Pro Glu Gly  Pro Ala Gly 
    1040                 1045                 1050             


Asn Asp  Gly Thr Pro Gly Arg  Asp Gly Ala Val Gly  Glu Arg Gly 
    1055                 1060                 1065             


Asp Arg  Gly Asp Pro Gly Pro  Ala Gly Leu Pro Gly  Ser Gln Gly 
    1070                 1075                 1080             


Ala Pro  Gly Thr Pro Gly Pro  Val Gly Ala Pro Gly  Asp Ala Gly 
    1085                 1090                 1095             


Gln Arg  Gly Asp Pro Gly Ser  Arg Gly Pro Ile Gly  Pro Pro Gly 
    1100                 1105                 1110             


Arg Ala  Gly Lys Arg Gly Leu  Pro Gly Pro Gln Gly  Pro Arg Gly 
    1115                 1120                 1125             


Asp Lys  Gly Asp His Gly Asp  Arg Gly Asp Arg Gly  Gln Lys Gly 
    1130                 1135                 1140             


His Arg  Gly Phe Thr Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly 
    1145                 1150                 1155             


Pro Asn  Gly Glu Gln Gly Ser  Ala Gly Ile Pro Gly  Pro Phe Gly 
    1160                 1165                 1170             


Pro Arg  Gly Pro Pro Gly Pro  Val Gly Pro Ser Gly  Lys Glu Gly 
    1175                 1180                 1185             


Asn Pro  Gly Pro Leu Gly Pro  Ile Gly Pro Pro Gly  Val Arg Gly 
    1190                 1195                 1200             


Ser Val  Gly Glu Ala Gly Pro  Glu Gly Pro Pro Gly  Glu Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly His Leu Thr  Ala Ala Leu 
    1220                 1225                 1230             


Gly Asp  Ile Met Gly His Tyr  Asp Glu Ser Met Pro  Asp Pro Leu 
    1235                 1240                 1245             


Pro Glu  Phe Thr Glu Asp Gln  Ala Ala Pro Asp Asp  Lys Asn Lys 
    1250                 1255                 1260             


Thr Asp  Pro Gly Val His Ala  Thr Leu Lys Ser Leu  Ser Ser Gln 
    1265                 1270                 1275             


Ile Glu  Thr Met Arg Ser Pro  Asp Gly Ser Lys Lys  His Pro Ala 
    1280                 1285                 1290             


Arg Thr  Cys Asp Asp Leu Lys  Leu Cys His Ser Ala  Lys Gln Ser 
    1295                 1300                 1305             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Ser Val  Glu Asp Ala 
    1310                 1315                 1320             


Ile Lys  Val Tyr Cys Asn Met  Glu Thr Gly Glu Thr  Cys Ile Ser 
    1325                 1330                 1335             


Ala Asn  Pro Ser Ser Val Pro  Arg Lys Thr Trp Trp  Ala Ser Lys 
    1340                 1345                 1350             


Ser Pro  Asp Asn Lys Pro Val  Trp Tyr Gly Leu Asp  Met Asn Arg 
    1355                 1360                 1365             


Gly Ser  Gln Phe Ala Tyr Gly  Asp His Gln Ser Pro  Asn Thr Ala 
    1370                 1375                 1380             


Ile Thr  Gln Met Thr Phe Leu  Arg Leu Leu Ser Lys  Glu Ala Ser 
    1385                 1390                 1395             


Gln Asn  Ile Thr Tyr Ile Cys  Lys Asn Ser Val Gly  Tyr Met Asp 
    1400                 1405                 1410             


Asp Gln  Ala Lys Asn Leu Lys  Lys Ala Val Val Leu  Lys Gly Ala 
    1415                 1420                 1425             


Asn Asp  Leu Asp Ile Lys Ala  Glu Gly Asn Ile Arg  Phe Arg Tyr 
    1430                 1435                 1440             


Ile Val  Leu Gln Asp Thr Cys  Ser Lys Arg Asn Gly  Asn Val Gly 
    1445                 1450                 1455             


Lys Thr  Val Phe Glu Tyr Arg  Thr Gln Asn Val Ala  Arg Leu Pro 
    1460                 1465                 1470             


Ile Ile  Asp Leu Ala Pro Val  Asp Val Gly Gly Thr  Asp Gln Glu 
    1475                 1480                 1485             


Phe Gly  Val Glu Ile Gly Pro  Val Cys Phe Val 
    1490                 1495                 


<210> 221
<211> 1028
<212> PRT
<213> Homo sapiens

<400> 221
Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210> 222
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 222
Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Glu Leu Ser Val Ala Gln Cys Thr Gln Arg Pro Val 
            820                 825                 830         


Asp Ile Val Phe Leu Leu Asp Gly Ser Glu Arg Leu Gly Glu Gln Asn 
        835                 840                 845             


Phe His Lys Ala Arg Arg Phe Val Glu Gln Val Ala Arg Arg Leu Thr 
    850                 855                 860                 


Leu Ala Arg Arg Asp Asp Asp Pro Leu Asn Ala Arg Val Ala Leu Leu 
865                 870                 875                 880 


Gln Phe Gly Gly Pro Gly Glu Gln Gln Val Ala Phe Pro Leu Ser His 
                885                 890                 895     


Asn Leu Thr Ala Ile His Glu Ala Leu Glu Thr Thr Gln Tyr Leu Asn 
            900                 905                 910         


Ser Phe Ser His Val Gly Ala Gly Val Val His Ala Ile Asn Ala Ile 
        915                 920                 925             


Val Arg Ser Pro Arg Gly Gly Ala Arg Arg His Ala Glu Leu Ser Phe 
    930                 935                 940                 


Val Phe Leu Thr Asp Gly Val Thr Gly Asn Asp Ser Leu His Glu Ser 
945                 950                 955                 960 


Ala His Ser Met Arg Lys Gln Asn Val Val Pro Thr Val Leu Ala Leu 
                965                 970                 975     


Gly Ser Asp Val Asp Met Asp Val Leu Thr Thr Leu Ser Leu Gly Asp 
            980                 985                 990         


Arg Ala Ala Val Phe His Glu Lys  Asp Tyr Asp Ser Leu  Ala Gln Pro 
        995                 1000                 1005             


Gly Phe  Phe Asp Arg Phe Ile  Arg Trp Ile Cys 
    1010                 1015                 


<210> 223
<211> 918
<212> PRT
<213> Homo sapiens

<400> 223
Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Asp Ala Pro Trp Pro Gly Gly Glu Pro Pro Val Thr 
            820                 825                 830         


Phe Leu Arg Thr Glu Glu Gly Pro Asp Ala Thr Phe Pro Arg Thr Ile 
        835                 840                 845             


Pro Leu Ile Gln Gln Leu Leu Asn Ala Thr Glu Leu Thr Gln Asp Pro 
    850                 855                 860                 


Ala Ala Tyr Ser Gln Leu Val Ala Val Leu Val Tyr Thr Ala Glu Arg 
865                 870                 875                 880 


Ala Lys Phe Ala Thr Gly Val Glu Arg Gln Asp Trp Met Glu Leu Phe 
                885                 890                 895     


Ile Asp Thr Phe Lys Leu Val His Arg Asp Ile Val Gly Asp Pro Glu 
            900                 905                 910         


Thr Ala Leu Ala Leu Cys 
        915             


<210> 224
<211> 828
<212> PRT
<213> Homo sapiens

<400> 224
Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Gly Leu Asp Gly Ala Val Leu Cys 
            820                 825             


<210> 225
<211> 2944
<212> PRT
<213> Homo sapiens

<400> 225
Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 
1               5                   10                  15      


Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 
            20                  25                  30          


Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 
    50                  55                  60                  


Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 
65                  70                  75                  80  


Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 
                85                  90                  95      


Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 
            100                 105                 110         


Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 
        115                 120                 125             


His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 
    130                 135                 140                 


Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 
145                 150                 155                 160 


Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 
                165                 170                 175     


Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 
            180                 185                 190         


Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 
        195                 200                 205             


Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 
    210                 215                 220                 


Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 
225                 230                 235                 240 


Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 
                245                 250                 255     


Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 
            260                 265                 270         


Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 
        275                 280                 285             


Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 
    290                 295                 300                 


Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 
305                 310                 315                 320 


Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 
                325                 330                 335     


Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 
            340                 345                 350         


Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 
        355                 360                 365             


Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 
    370                 375                 380                 


Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 
385                 390                 395                 400 


Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 
                405                 410                 415     


Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 
            420                 425                 430         


Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 
        435                 440                 445             


Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 
    450                 455                 460                 


Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 
465                 470                 475                 480 


Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 
                485                 490                 495     


Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 
            500                 505                 510         


Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 
        515                 520                 525             


Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 
    530                 535                 540                 


Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 
545                 550                 555                 560 


Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 
                565                 570                 575     


Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 
            580                 585                 590         


Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 
        595                 600                 605             


Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 
    610                 615                 620                 


Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 
625                 630                 635                 640 


Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 
                645                 650                 655     


Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 
            660                 665                 670         


Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 
        675                 680                 685             


Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 
    690                 695                 700                 


Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 
705                 710                 715                 720 


Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 
                725                 730                 735     


Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 
            740                 745                 750         


Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 
        755                 760                 765             


Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 
    770                 775                 780                 


Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 
785                 790                 795                 800 


Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 
                805                 810                 815     


Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 
            820                 825                 830         


Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 
        835                 840                 845             


Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 
    850                 855                 860                 


Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 
865                 870                 875                 880 


His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 
                885                 890                 895     


Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 
            900                 905                 910         


Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 
        915                 920                 925             


Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 
    930                 935                 940                 


Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 
945                 950                 955                 960 


Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 
                965                 970                 975     


Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 
            980                 985                 990         


Arg Gly Pro Gly Gln Glu Val Pro  Gly Ser Pro Gln Thr  Leu Pro Gly 
        995                 1000                 1005             


Ile Ser  Ser Ser Gln Arg Val  Thr Gly Leu Glu Pro  Gly Val Ser 
    1010                 1015                 1020             


Tyr Ile  Phe Ser Leu Thr Pro  Val Leu Asp Gly Val  Arg Gly Pro 
    1025                 1030                 1035             


Glu Ala  Ser Val Thr Gln Thr  Pro Val Cys Pro Arg  Gly Leu Ala 
    1040                 1045                 1050             


Asp Val  Val Phe Leu Pro His  Ala Thr Gln Asp Asn  Ala His Arg 
    1055                 1060                 1065             


Ala Glu  Ala Thr Arg Arg Val  Leu Glu Arg Leu Val  Leu Ala Leu 
    1070                 1075                 1080             


Gly Pro  Leu Gly Pro Gln Ala  Val Gln Val Gly Leu  Leu Ser Tyr 
    1085                 1090                 1095             


Ser His  Arg Pro Ser Pro Leu  Phe Pro Leu Asn Gly  Ser His Asp 
    1100                 1105                 1110             


Leu Gly  Ile Ile Leu Gln Arg  Ile Arg Asp Met Pro  Tyr Met Asp 
    1115                 1120                 1125             


Pro Ser  Gly Asn Asn Leu Gly  Thr Ala Val Val Thr  Ala His Arg 
    1130                 1135                 1140             


Tyr Met  Leu Ala Pro Asp Ala  Pro Gly Arg Arg Gln  His Val Pro 
    1145                 1150                 1155             


Gly Val  Met Val Leu Leu Val  Asp Glu Pro Leu Arg  Gly Asp Ile 
    1160                 1165                 1170             


Phe Ser  Pro Ile Arg Glu Ala  Gln Ala Ser Gly Leu  Asn Val Val 
    1175                 1180                 1185             


Met Leu  Gly Met Ala Gly Ala  Asp Pro Glu Gln Leu  Arg Arg Leu 
    1190                 1195                 1200             


Ala Pro  Gly Met Asp Ser Val  Gln Thr Phe Phe Ala  Val Asp Asp 
    1205                 1210                 1215             


Gly Pro  Ser Leu Asp Gln Ala  Val Ser Gly Leu Ala  Thr Ala Leu 
    1220                 1225                 1230             


Cys Gln  Ala Ser Phe Thr Thr  Gln Pro Arg Pro Glu  Pro Cys Pro 
    1235                 1240                 1245             


Val Tyr  Cys Pro Lys Gly Gln  Lys Gly Glu Pro Gly  Glu Met Gly 
    1250                 1255                 1260             


Leu Arg  Gly Gln Val Gly Pro  Pro Gly Asp Pro Gly  Leu Pro Gly 
    1265                 1270                 1275             


Arg Thr  Gly Ala Pro Gly Pro  Gln Gly Pro Pro Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ala Lys  Gly Glu Arg Gly Phe  Pro Gly Ala Asp Gly  Arg Pro Gly 
    1295                 1300                 1305             


Ser Pro  Gly Arg Ala Gly Asn  Pro Gly Thr Pro Gly  Ala Pro Gly 
    1310                 1315                 1320             


Leu Lys  Gly Ser Pro Gly Leu  Pro Gly Pro Arg Gly  Asp Pro Gly 
    1325                 1330                 1335             


Glu Arg  Gly Pro Arg Gly Pro  Lys Gly Glu Pro Gly  Ala Pro Gly 
    1340                 1345                 1350             


Gln Val  Ile Gly Gly Glu Gly  Pro Gly Leu Pro Gly  Arg Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Pro Ser Gly Pro  Pro Gly Pro Arg Gly  Pro Leu Gly 
    1370                 1375                 1380             


Asp Pro  Gly Pro Arg Gly Pro  Pro Gly Leu Pro Gly  Thr Ala Met 
    1385                 1390                 1395             


Lys Gly  Asp Lys Gly Asp Arg  Gly Glu Arg Gly Pro  Pro Gly Pro 
    1400                 1405                 1410             


Gly Glu  Gly Gly Ile Ala Pro  Gly Glu Pro Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Ser Pro Gly Pro Gln  Gly Pro Val Gly Pro  Pro Gly Lys 
    1430                 1435                 1440             


Lys Gly  Glu Lys Gly Asp Ser  Glu Asp Gly Ala Pro  Gly Leu Pro 
    1445                 1450                 1455             


Gly Gln  Pro Gly Ser Pro Gly  Glu Gln Gly Pro Arg  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Ile Gly Pro Lys Gly  Asp Arg Gly Phe Pro  Gly Pro Leu 
    1475                 1480                 1485             


Gly Glu  Ala Gly Glu Lys Gly  Glu Arg Gly Pro Pro  Gly Pro Ala 
    1490                 1495                 1500             


Gly Ser  Arg Gly Leu Pro Gly  Val Ala Gly Arg Pro  Gly Ala Lys 
    1505                 1510                 1515             


Gly Pro  Glu Gly Pro Pro Gly  Pro Thr Gly Arg Gln  Gly Glu Lys 
    1520                 1525                 1530             


Gly Glu  Pro Gly Arg Pro Gly  Asp Pro Ala Val Val  Gly Pro Ala 
    1535                 1540                 1545             


Val Ala  Gly Pro Lys Gly Glu  Lys Gly Asp Val Gly  Pro Ala Gly 
    1550                 1555                 1560             


Pro Arg  Gly Ala Thr Gly Val  Gln Gly Glu Arg Gly  Pro Pro Gly 
    1565                 1570                 1575             


Leu Val  Leu Pro Gly Asp Pro  Gly Pro Lys Gly Asp  Pro Gly Asp 
    1580                 1585                 1590             


Arg Gly  Pro Ile Gly Leu Thr  Gly Arg Ala Gly Pro  Pro Gly Asp 
    1595                 1600                 1605             


Ser Gly  Pro Pro Gly Glu Lys  Gly Asp Pro Gly Arg  Pro Gly Pro 
    1610                 1615                 1620             


Pro Gly  Pro Val Gly Pro Arg  Gly Arg Asp Gly Glu  Val Gly Glu 
    1625                 1630                 1635             


Lys Gly  Asp Glu Gly Pro Pro  Gly Asp Pro Gly Leu  Pro Gly Lys 
    1640                 1645                 1650             


Ala Gly  Glu Arg Gly Leu Arg  Gly Ala Pro Gly Val  Arg Gly Pro 
    1655                 1660                 1665             


Val Gly  Glu Lys Gly Asp Gln  Gly Asp Pro Gly Glu  Asp Gly Arg 
    1670                 1675                 1680             


Asn Gly  Ser Pro Gly Ser Ser  Gly Pro Lys Gly Asp  Arg Gly Glu 
    1685                 1690                 1695             


Pro Gly  Pro Pro Gly Pro Pro  Gly Arg Leu Val Asp  Thr Gly Pro 
    1700                 1705                 1710             


Gly Ala  Arg Glu Lys Gly Glu  Pro Gly Asp Arg Gly  Gln Glu Gly 
    1715                 1720                 1725             


Pro Arg  Gly Pro Lys Gly Asp  Pro Gly Leu Pro Gly  Ala Pro Gly 
    1730                 1735                 1740             


Glu Arg  Gly Ile Glu Gly Phe  Arg Gly Pro Pro Gly  Pro Gln Gly 
    1745                 1750                 1755             


Asp Pro  Gly Val Arg Gly Pro  Ala Gly Glu Lys Gly  Asp Arg Gly 
    1760                 1765                 1770             


Pro Pro  Gly Leu Asp Gly Arg  Ser Gly Leu Asp Gly  Lys Pro Gly 
    1775                 1780                 1785             


Ala Ala  Gly Pro Ser Gly Pro  Asn Gly Ala Ala Gly  Lys Ala Gly 
    1790                 1795                 1800             


Asp Pro  Gly Arg Asp Gly Leu  Pro Gly Leu Arg Gly  Glu Gln Gly 
    1805                 1810                 1815             


Leu Pro  Gly Pro Ser Gly Pro  Pro Gly Leu Pro Gly  Lys Pro Gly 
    1820                 1825                 1830             


Glu Asp  Gly Lys Pro Gly Leu  Asn Gly Lys Asn Gly  Glu Pro Gly 
    1835                 1840                 1845             


Asp Pro  Gly Glu Asp Gly Arg  Lys Gly Glu Lys Gly  Asp Ser Gly 
    1850                 1855                 1860             


Ala Ser  Gly Arg Glu Gly Arg  Asp Gly Pro Lys Gly  Glu Arg Gly 
    1865                 1870                 1875             


Ala Pro  Gly Ile Leu Gly Pro  Gln Gly Pro Pro Gly  Leu Pro Gly 
    1880                 1885                 1890             


Pro Val  Gly Pro Pro Gly Gln  Gly Phe Pro Gly Val  Pro Gly Gly 
    1895                 1900                 1905             


Thr Gly  Pro Lys Gly Asp Arg  Gly Glu Thr Gly Ser  Lys Gly Glu 
    1910                 1915                 1920             


Gln Gly  Leu Pro Gly Glu Arg  Gly Leu Arg Gly Glu  Pro Gly Ser 
    1925                 1930                 1935             


Val Pro  Asn Val Asp Arg Leu  Leu Glu Thr Ala Gly  Ile Lys Ala 
    1940                 1945                 1950             


Ser Ala  Leu Arg Glu Ile Val  Glu Thr Trp Asp Glu  Ser Ser Gly 
    1955                 1960                 1965             


Ser Phe  Leu Pro Val Pro Glu  Arg Arg Arg Gly Pro  Lys Gly Asp 
    1970                 1975                 1980             


Ser Gly  Glu Gln Gly Pro Pro  Gly Lys Glu Gly Pro  Ile Gly Phe 
    1985                 1990                 1995             


Pro Gly  Glu Arg Gly Leu Lys  Gly Asp Arg Gly Asp  Pro Gly Pro 
    2000                 2005                 2010             


Gln Gly  Pro Pro Gly Leu Ala  Leu Gly Glu Arg Gly  Pro Pro Gly 
    2015                 2020                 2025             


Pro Ser  Gly Leu Ala Gly Glu  Pro Gly Lys Pro Gly  Ile Pro Gly 
    2030                 2035                 2040             


Leu Pro  Gly Arg Ala Gly Gly  Val Gly Glu Ala Gly  Arg Pro Gly 
    2045                 2050                 2055             


Glu Arg  Gly Glu Arg Gly Glu  Lys Gly Glu Arg Gly  Glu Gln Gly 
    2060                 2065                 2070             


Arg Asp  Gly Pro Pro Gly Leu  Pro Gly Thr Pro Gly  Pro Pro Gly 
    2075                 2080                 2085             


Pro Pro  Gly Pro Lys Val Ser  Val Asp Glu Pro Gly  Pro Gly Leu 
    2090                 2095                 2100             


Ser Gly  Glu Gln Gly Pro Pro  Gly Leu Lys Gly Ala  Lys Gly Glu 
    2105                 2110                 2115             


Pro Gly  Ser Asn Gly Asp Gln  Gly Pro Lys Gly Asp  Arg Gly Val 
    2120                 2125                 2130             


Pro Gly  Ile Lys Gly Asp Arg  Gly Glu Pro Gly Pro  Arg Gly Gln 
    2135                 2140                 2145             


Asp Gly  Asn Pro Gly Leu Pro  Gly Glu Arg Gly Met  Ala Gly Pro 
    2150                 2155                 2160             


Glu Gly  Lys Pro Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    2165                 2170                 2175             


Val Gly  Gly His Gly Asp Pro  Gly Pro Pro Gly Ala  Pro Gly Leu 
    2180                 2185                 2190             


Ala Gly  Pro Ala Gly Pro Gln  Gly Pro Ser Gly Leu  Lys Gly Glu 
    2195                 2200                 2205             


Pro Gly  Glu Thr Gly Pro Pro  Gly Arg Gly Leu Thr  Gly Pro Thr 
    2210                 2215                 2220             


Gly Ala  Val Gly Leu Pro Gly  Pro Pro Gly Pro Ser  Gly Leu Val 
    2225                 2230                 2235             


Gly Pro  Gln Gly Ser Pro Gly  Leu Pro Gly Gln Val  Gly Glu Thr 
    2240                 2245                 2250             


Gly Lys  Pro Gly Ala Pro Gly  Arg Asp Gly Ala Ser  Gly Lys Asp 
    2255                 2260                 2265             


Gly Asp  Arg Gly Ser Pro Gly  Val Pro Gly Ser Pro  Gly Leu Pro 
    2270                 2275                 2280             


Gly Pro  Val Gly Pro Lys Gly  Glu Pro Gly Pro Thr  Gly Ala Pro 
    2285                 2290                 2295             


Gly Gln  Ala Val Val Gly Leu  Pro Gly Ala Lys Gly  Glu Lys Gly 
    2300                 2305                 2310             


Ala Pro  Gly Gly Leu Ala Gly  Asp Leu Val Gly Glu  Pro Gly Ala 
    2315                 2320                 2325             


Lys Gly  Asp Arg Gly Leu Pro  Gly Pro Arg Gly Glu  Lys Gly Glu 
    2330                 2335                 2340             


Ala Gly  Arg Ala Gly Glu Pro  Gly Asp Pro Gly Glu  Asp Gly Gln 
    2345                 2350                 2355             


Lys Gly  Ala Pro Gly Pro Lys  Gly Phe Lys Gly Asp  Pro Gly Val 
    2360                 2365                 2370             


Gly Val  Pro Gly Ser Pro Gly  Pro Pro Gly Pro Pro  Gly Val Lys 
    2375                 2380                 2385             


Gly Asp  Leu Gly Leu Pro Gly  Leu Pro Gly Ala Pro  Gly Val Val 
    2390                 2395                 2400             


Gly Phe  Pro Gly Gln Thr Gly  Pro Arg Gly Glu Met  Gly Gln Pro 
    2405                 2410                 2415             


Gly Pro  Ser Gly Glu Arg Gly  Leu Ala Gly Pro Pro  Gly Arg Glu 
    2420                 2425                 2430             


Gly Ile  Pro Gly Pro Leu Gly  Pro Pro Gly Pro Pro  Gly Ser Val 
    2435                 2440                 2445             


Gly Pro  Pro Gly Ala Ser Gly  Leu Lys Gly Asp Lys  Gly Asp Pro 
    2450                 2455                 2460             


Gly Val  Gly Leu Pro Gly Pro  Arg Gly Glu Arg Gly  Glu Pro Gly 
    2465                 2470                 2475             


Ile Arg  Gly Glu Asp Gly Arg  Pro Gly Gln Glu Gly  Pro Arg Gly 
    2480                 2485                 2490             


Leu Thr  Gly Pro Pro Gly Ser  Arg Gly Glu Arg Gly  Glu Lys Gly 
    2495                 2500                 2505             


Asp Val  Gly Ser Ala Gly Leu  Lys Gly Asp Lys Gly  Asp Ser Ala 
    2510                 2515                 2520             


Val Ile  Leu Gly Pro Pro Gly  Pro Arg Gly Ala Lys  Gly Asp Met 
    2525                 2530                 2535             


Gly Glu  Arg Gly Pro Arg Gly  Leu Asp Gly Asp Lys  Gly Pro Arg 
    2540                 2545                 2550             


Gly Asp  Asn Gly Asp Pro Gly  Asp Lys Gly Ser Lys  Gly Glu Pro 
    2555                 2560                 2565             


Gly Asp  Lys Gly Ser Ala Gly  Leu Pro Gly Leu Arg  Gly Leu Leu 
    2570                 2575                 2580             


Gly Pro  Gln Gly Gln Pro Gly  Ala Ala Gly Ile Pro  Gly Asp Pro 
    2585                 2590                 2595             


Gly Ser  Pro Gly Lys Asp Gly  Val Pro Gly Ile Arg  Gly Glu Lys 
    2600                 2605                 2610             


Gly Asp  Val Gly Phe Met Gly  Pro Arg Gly Leu Lys  Gly Glu Arg 
    2615                 2620                 2625             


Gly Val  Lys Gly Ala Cys Gly  Leu Asp Gly Glu Lys  Gly Asp Lys 
    2630                 2635                 2640             


Gly Glu  Ala Gly Pro Pro Gly  Arg Pro Gly Leu Ala  Gly His Lys 
    2645                 2650                 2655             


Gly Glu  Met Gly Glu Pro Gly  Val Pro Gly Gln Ser  Gly Ala Pro 
    2660                 2665                 2670             


Gly Lys  Glu Gly Leu Ile Gly  Pro Lys Gly Asp Arg  Gly Phe Asp 
    2675                 2680                 2685             


Gly Gln  Pro Gly Pro Lys Gly  Asp Gln Gly Glu Lys  Gly Glu Arg 
    2690                 2695                 2700             


Gly Thr  Pro Gly Ile Gly Gly  Phe Pro Gly Pro Ser  Gly Asn Asp 
    2705                 2710                 2715             


Gly Ser  Ala Gly Pro Pro Gly  Pro Pro Gly Ser Val  Gly Pro Arg 
    2720                 2725                 2730             


Gly Pro  Glu Gly Leu Gln Gly  Gln Lys Gly Glu Arg  Gly Pro Pro 
    2735                 2740                 2745             


Gly Glu  Arg Val Val Gly Ala  Pro Gly Val Pro Gly  Ala Pro Gly 
    2750                 2755                 2760             


Glu Arg  Gly Glu Gln Gly Arg  Pro Gly Pro Ala Gly  Pro Arg Gly 
    2765                 2770                 2775             


Glu Lys  Gly Glu Ala Ala Leu  Thr Glu Asp Asp Ile  Arg Gly Phe 
    2780                 2785                 2790             


Val Arg  Gln Glu Met Ser Gln  His Cys Ala Cys Gln  Gly Gln Phe 
    2795                 2800                 2805             


Ile Ala  Ser Gly Ser Arg Pro  Leu Pro Ser Tyr Ala  Ala Asp Thr 
    2810                 2815                 2820             


Ala Gly  Ser Gln Leu His Ala  Val Pro Val Leu Arg  Val Ser His 
    2825                 2830                 2835             


Ala Glu  Glu Glu Glu Arg Val  Pro Pro Glu Asp Asp  Glu Tyr Ser 
    2840                 2845                 2850             


Glu Tyr  Ser Glu Tyr Ser Val  Glu Glu Tyr Gln Asp  Pro Glu Ala 
    2855                 2860                 2865             


Pro Trp  Asp Ser Asp Asp Pro  Cys Ser Leu Pro Leu  Asp Glu Gly 
    2870                 2875                 2880             


Ser Cys  Thr Ala Tyr Thr Leu  Arg Trp Tyr His Arg  Ala Val Thr 
    2885                 2890                 2895             


Gly Ser  Thr Glu Ala Cys His  Pro Phe Val Tyr Gly  Gly Cys Gly 
    2900                 2905                 2910             


Gly Asn  Ala Asn Arg Phe Gly  Thr Arg Glu Ala Cys  Glu Arg Arg 
    2915                 2920                 2925             


Cys Pro  Pro Arg Val Val Gln  Ser Gln Gly Thr Gly  Thr Ala Gln 
    2930                 2935                 2940             


Asp 
    


<210> 226
<211> 744
<212> PRT
<213> Homo sapiens

<400> 226
Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly 
        195                 200                 205             


Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp 
    210                 215                 220                 


Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
225                 230                 235                 240 


Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro 
                245                 250                 255     


Pro Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            260                 265                 270         


Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys 
        275                 280                 285             


Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
    290                 295                 300                 


Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln 
305                 310                 315                 320 


Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln 
                325                 330                 335     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys 
            340                 345                 350         


Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly 
    370                 375                 380                 


Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro 
385                 390                 395                 400 


Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
                405                 410                 415     


Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly 
            420                 425                 430         


Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro 
        435                 440                 445             


Pro Gly Met Arg Gly Leu Pro Gly Pro Ile Gly Pro Lys Gly Glu Ala 
    450                 455                 460                 


Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro 
                485                 490                 495     


Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            500                 505                 510         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
        515                 520                 525             


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro 
    530                 535                 540                 


Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro 
                565                 570                 575     


Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile 
            580                 585                 590         


Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn 
        595                 600                 605             


Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala 
    610                 615                 620                 


Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr 
625                 630                 635                 640 


Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu 
                645                 650                 655     


Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly 
            660                 665                 670         


Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr 
        675                 680                 685             


Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala 
    690                 695                 700                 


Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser 
705                 710                 715                 720 


Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe 
                725                 730                 735     


Ser Gly Tyr Leu Leu Tyr Pro Met 
            740                 


<210> 227
<211> 703
<212> PRT
<213> Homo sapiens

<400> 227
Met Leu Gly Thr Leu Thr Pro Leu Ser Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Leu Gly Cys Gly Pro Arg Ala Ser Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Ala Ala Gly Tyr Ala Pro Val Lys Tyr Ile Gln Pro Met Gln 
        35                  40                  45              


Lys Gly Pro Val Gly Pro Pro Phe Arg Glu Gly Lys Gly Gln Tyr Leu 
    50                  55                  60                  


Glu Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe 
                85                  90                  95      


Pro Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly 
            100                 105                 110         


Pro Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro 
        115                 120                 125             


Gly Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly 
    130                 135                 140                 


Glu Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly 
                165                 170                 175     


Ala Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro 
            180                 185                 190         


Gln Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn 
        195                 200                 205             


Gly Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala 
    210                 215                 220                 


Pro Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly 
225                 230                 235                 240 


Leu Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro 
                245                 250                 255     


Pro Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys 
            260                 265                 270         


Gly Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu 
        275                 280                 285             


Pro Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu 
                325                 330                 335     


Gly Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly 
            340                 345                 350         


Pro Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu 
        355                 360                 365             


Pro Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly 
    370                 375                 380                 


Gly Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly 
385                 390                 395                 400 


Leu Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala 
                405                 410                 415     


His Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr 
            420                 425                 430         


Gly Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly 
        435                 440                 445             


Asp Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile 
    450                 455                 460                 


Pro Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro 
465                 470                 475                 480 


Gly Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg 
                485                 490                 495     


Ala Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro 
            500                 505                 510         


Gly Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        515                 520                 525             


Pro Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu 
    530                 535                 540                 


His Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly 
545                 550                 555                 560 


Lys Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala 
                565                 570                 575     


Phe Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val 
            580                 585                 590         


Lys Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala 
        595                 600                 605             


Thr Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr 
    610                 615                 620                 


His Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn 
625                 630                 635                 640 


Asn Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu 
                645                 650                 655     


Asp Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln 
            660                 665                 670         


Val Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr 
        675                 680                 685             


Glu Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
    690                 695                 700             


<210> 228
<211> 638
<212> PRT
<213> Homo sapiens

<400> 228
Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly Pro 
1               5                   10                  15      


Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe Pro 
            20                  25                  30          


Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly Pro 
        35                  40                  45              


Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro Gly 
    50                  55                  60                  


Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly Glu 
65                  70                  75                  80  


Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro Pro 
                85                  90                  95      


Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly Ala 
            100                 105                 110         


Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro Gln 
        115                 120                 125             


Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn Gly 
    130                 135                 140                 


Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala Pro 
145                 150                 155                 160 


Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly Leu 
                165                 170                 175     


Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Pro 
            180                 185                 190         


Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys Gly 
        195                 200                 205             


Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu Pro 
    210                 215                 220                 


Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg Gly 
225                 230                 235                 240 


Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu Pro 
                245                 250                 255     


Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu Gly 
            260                 265                 270         


Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly Pro 
        275                 280                 285             


Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu Pro 
    290                 295                 300                 


Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly Gly 
305                 310                 315                 320 


Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly Leu 
                325                 330                 335     


Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala His 
            340                 345                 350         


Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr Gly 
        355                 360                 365             


Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly Asp 
    370                 375                 380                 


Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile Pro 
385                 390                 395                 400 


Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro Gly 
                405                 410                 415     


Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg Ala 
            420                 425                 430         


Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro Gly 
        435                 440                 445             


Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu His 
465                 470                 475                 480 


Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly Lys 
                485                 490                 495     


Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala Phe 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val Lys 
        515                 520                 525             


Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala Thr 
    530                 535                 540                 


Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr His 
545                 550                 555                 560 


Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn Asn 
                565                 570                 575     


Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu Asp 
            580                 585                 590         


Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln Val 
        595                 600                 605             


Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr Glu 
    610                 615                 620                 


Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
625                 630                 635             


<210> 229
<211> 1899
<212> PRT
<213> Homo sapiens

<400> 229
Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Gly Met Glu Cys Leu Thr Arg Ala 
            20                  25                  30          


Glu Ala Asp Ile Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg 
        35                  40                  45              


Ala Asn Phe Arg Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val 
    50                  55                  60                  


Phe Asp Ile Gly Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser 
65                  70                  75                  80  


Gly Asp Pro Arg Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys 
                85                  90                  95      


Ser Leu Leu Gln Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr 
            100                 105                 110         


Leu Thr Gly Met Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr 
        115                 120                 125             


Gln Ala Gly Met Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr 
    130                 135                 140                 


Asp Gly Lys Ser Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys 
145                 150                 155                 160 


Asp Glu Gly Val Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu 
                165                 170                 175     


Val Glu Leu Lys Met Ile Ala Thr Asp Pro Asp Asp Thr His Ala Tyr 
            180                 185                 190         


Asn Val Ala Asp Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr 
        195                 200                 205             


Ile Asn Leu Cys Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro 
    210                 215                 220                 


Ser Asn Leu Val Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser 
225                 230                 235                 240 


Trp Thr Pro Pro Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr 
                245                 250                 255     


Pro Val Ser Gly Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu 
            260                 265                 270         


Thr Ser Thr Val Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val 
        275                 280                 285             


Asn Val Tyr Ser Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly 
    290                 295                 300                 


Thr Glu Lys Thr Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp 
305                 310                 315                 320 


Val Gly Pro Thr Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala 
                325                 330                 335     


Thr Gly Tyr Ile Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr 
            340                 345                 350         


Arg Pro Lys Glu Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu 
        355                 360                 365             


Thr Asp Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val 
    370                 375                 380                 


Leu His Asp Leu Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu 
385                 390                 395                 400 


Pro Leu Pro Arg Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser 
                405                 410                 415     


Thr Met Asn Val Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr 
            420                 425                 430         


Ile Val Arg Tyr Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val 
        435                 440                 445             


Asp Arg Ser Glu Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr 
    450                 455                 460                 


Leu Tyr Thr Val Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro 
465                 470                 475                 480 


Pro Val Thr Ala Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn 
                485                 490                 495     


Leu Lys Ile Thr Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp 
            500                 505                 510         


His Gly Ala Ser Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala Pro Phe 
        515                 520                 525             


Gly Ser Ser Asp Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr 
    530                 535                 540                 


Leu Val Phe Glu Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile 
545                 550                 555                 560 


Thr Ala Ile Tyr Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser 
                565                 570                 575     


Glu Arg Thr Leu Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro 
            580                 585                 590         


Arg Asn Leu Gln Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys 
        595                 600                 605             


Trp Asp Pro Ala Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln 
    610                 615                 620                 


Pro Ser Thr Gly Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg 
625                 630                 635                 640 


Gln Asn Ser Val Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr 
                645                 650                 655     


Ile Thr Val Ser Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr 
            660                 665                 670         


Gly Arg Gly Lys Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val 
        675                 680                 685             


Tyr Asp Pro Ser Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu 
    690                 695                 700                 


Gly Asn Pro Arg Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly 
705                 710                 715                 720 


Pro Glu Glu Leu Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu 
                725                 730                 735     


Arg Asn Leu Gln Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val 
            740                 745                 750         


Tyr Thr Glu Gly Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu 
        755                 760                 765             


Met Arg Gly Leu Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn 
    770                 775                 780                 


Ser Leu Asp Val Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr 
785                 790                 795                 800 


Arg Val Val Tyr Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile 
                805                 810                 815     


Val Val Pro Gly Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro 
            820                 825                 830         


Asp Thr Leu Tyr Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu 
        835                 840                 845             


Gly Asn Pro Ser Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro 
    850                 855                 860                 


Arg Asn Leu Arg Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala 
865                 870                 875                 880 


Trp Asp His Ala Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser 
                885                 890                 895     


Pro Thr Val Gly Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg 
            900                 905                 910         


Arg Asn Asn Val Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys 
        915                 920                 925             


Ile Thr Val Ile Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr 
    930                 935                 940                 


Gly Asn Gly Arg Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile 
945                 950                 955                 960 


Ser Asp Glu Trp Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro 
                965                 970                 975     


Ser Pro Val Leu Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn 
            980                 985                 990         


Glu Pro Met Glu Ala Phe Val Gly  Glu Met Thr Ser Tyr  Thr Leu His 
        995                 1000                 1005             


Asn Leu  Asn Pro Ser Thr Thr  Tyr Asp Val Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Tyr Asp  Ser Gly Leu Ser Val  Pro Leu Thr Asp Gln  Gly Thr Thr 
    1025                 1030                 1035             


Leu Tyr  Leu Asn Val Thr Asp  Leu Lys Thr Tyr Gln  Ile Gly Trp 
    1040                 1045                 1050             


Asp Thr  Phe Cys Val Lys Trp  Ser Pro His Arg Ala  Ala Thr Ser 
    1055                 1060                 1065             


Tyr Arg  Leu Lys Leu Ser Pro  Ala Asp Gly Thr Arg  Gly Gln Glu 
    1070                 1075                 1080             


Ile Thr  Val Arg Gly Ser Glu  Thr Ser His Cys Phe  Thr Gly Leu 
    1085                 1090                 1095             


Ser Pro  Asp Thr Asp Tyr Gly  Val Thr Val Phe Val  Gln Thr Pro 
    1100                 1105                 1110             


Asn Leu  Glu Gly Pro Gly Val  Ser Val Lys Glu His  Thr Thr Val 
    1115                 1120                 1125             


Lys Pro  Thr Glu Ala Pro Thr  Glu Pro Pro Thr Pro  Pro Pro Pro 
    1130                 1135                 1140             


Pro Thr  Ile Pro Pro Ala Arg  Asp Val Cys Lys Gly  Ala Lys Ala 
    1145                 1150                 1155             


Asp Ile  Val Phe Leu Thr Asp  Ala Ser Trp Ser Ile  Gly Asp Asp 
    1160                 1165                 1170             


Asn Phe  Asn Lys Val Val Lys  Phe Ile Phe Asn Thr  Val Gly Gly 
    1175                 1180                 1185             


Phe Asp  Glu Ile Ser Pro Ala  Gly Ile Gln Val Ser  Phe Val Gln 
    1190                 1195                 1200             


Tyr Ser  Asp Glu Val Lys Ser  Glu Phe Lys Leu Asn  Thr Tyr Asn 
    1205                 1210                 1215             


Asp Lys  Ala Leu Ala Leu Gly  Ala Leu Gln Asn Ile  Arg Tyr Arg 
    1220                 1225                 1230             


Gly Gly  Asn Thr Arg Thr Gly  Lys Ala Leu Thr Phe  Ile Lys Glu 
    1235                 1240                 1245             


Lys Val  Leu Thr Trp Glu Ser  Gly Met Arg Lys Asn  Val Pro Lys 
    1250                 1255                 1260             


Val Leu  Val Val Val Thr Asp  Gly Arg Ser Gln Asp  Glu Val Lys 
    1265                 1270                 1275             


Lys Ala  Ala Leu Val Ile Gln  Gln Ser Gly Phe Ser  Val Phe Val 
    1280                 1285                 1290             


Val Gly  Val Ala Asp Val Asp  Tyr Asn Glu Leu Ala  Asn Ile Ala 
    1295                 1300                 1305             


Ser Lys  Pro Ser Glu Arg His  Val Phe Ile Val Asp  Asp Phe Glu 
    1310                 1315                 1320             


Ser Phe  Glu Lys Ile Glu Asp  Asn Leu Ile Thr Phe  Val Cys Glu 
    1325                 1330                 1335             


Thr Ala  Thr Ser Ser Cys Pro  Leu Ile Tyr Leu Asp  Gly Tyr Thr 
    1340                 1345                 1350             


Ser Pro  Gly Phe Lys Met Leu  Glu Ala Tyr Asn Leu  Thr Glu Lys 
    1355                 1360                 1365             


Asn Phe  Ala Ser Val Gln Gly  Val Ser Leu Glu Ser  Gly Ser Phe 
    1370                 1375                 1380             


Pro Ser  Tyr Ser Ala Tyr Arg  Ile Gln Lys Asn Ala  Phe Val Asn 
    1385                 1390                 1395             


Gln Pro  Thr Ala Asp Leu His  Pro Asn Gly Leu Pro  Pro Ser Tyr 
    1400                 1405                 1410             


Thr Ile  Ile Leu Leu Phe Arg  Leu Leu Pro Glu Thr  Pro Ser Asp 
    1415                 1420                 1425             


Pro Phe  Ala Ile Trp Gln Ile  Thr Asp Arg Asp Tyr  Lys Pro Gln 
    1430                 1435                 1440             


Val Gly  Val Ile Ala Asp Pro  Ser Ser Lys Thr Leu  Ser Phe Phe 
    1445                 1450                 1455             


Asn Lys  Asp Thr Arg Gly Glu  Val Gln Thr Val Thr  Phe Asp Thr 
    1460                 1465                 1470             


Glu Glu  Val Lys Thr Leu Phe  Tyr Gly Ser Phe His  Lys Val His 
    1475                 1480                 1485             


Ile Val  Val Thr Ser Lys Ser  Val Lys Ile Tyr Ile  Asp Cys Tyr 
    1490                 1495                 1500             


Glu Ile  Ile Glu Lys Asp Ile  Lys Glu Ala Gly Asn  Ile Thr Thr 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Ile Leu Gly  Lys Leu Leu Lys Gly  Glu Arg Lys 
    1520                 1525                 1530             


Ser Ala  Ala Phe Gln Ile Gln  Ser Phe Asp Ile Val  Cys Ser Pro 
    1535                 1540                 1545             


Val Trp  Thr Ser Arg Asp Arg  Cys Cys Asp Ile Pro  Ser Arg Arg 
    1550                 1555                 1560             


Asp Glu  Gly Lys Cys Pro Ala  Phe Pro Asn Ser Cys  Thr Cys Thr 
    1565                 1570                 1575             


Gln Asp  Ser Val Gly Pro Pro  Gly Pro Pro Gly Pro  Ala Gly Gly 
    1580                 1585                 1590             


Pro Gly  Ala Lys Gly Pro Arg  Gly Glu Arg Gly Ile  Ser Gly Ala 
    1595                 1600                 1605             


Ile Gly  Pro Pro Gly Pro Arg  Gly Asp Ile Gly Pro  Pro Gly Pro 
    1610                 1615                 1620             


Gln Gly  Pro Pro Gly Pro Gln  Gly Pro Asn Gly Leu  Ser Ile Pro 
    1625                 1630                 1635             


Gly Glu  Gln Gly Arg Gln Gly  Met Lys Gly Asp Ala  Gly Glu Pro 
    1640                 1645                 1650             


Gly Leu  Pro Gly Arg Thr Gly  Thr Pro Gly Leu Pro  Gly Pro Pro 
    1655                 1660                 1665             


Gly Pro  Met Gly Pro Pro Gly  Asp Arg Gly Phe Thr  Gly Lys Asp 
    1670                 1675                 1680             


Gly Ala  Met Gly Pro Arg Gly  Pro Pro Gly Pro Pro  Gly Ser Pro 
    1685                 1690                 1695             


Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly Lys Pro  Gly Lys Pro 
    1700                 1705                 1710             


Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly Leu Lys  Gly Glu Lys 
    1715                 1720                 1725             


Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn Met Met  Arg Ala Val 
    1730                 1735                 1740             


Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser Gly Gln  Met Asn Arg 
    1745                 1750                 1755             


Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn Asp Tyr  Gln Ser Ser 
    1760                 1765                 1770             


Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ser 
    1775                 1780                 1785             


Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly Gly Arg  Pro Gly Phe 
    1790                 1795                 1800             


Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro Gly Glu  Arg Gly Leu 
    1805                 1810                 1815             


Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly Ser Ser  Gly Pro Arg 
    1820                 1825                 1830             


Gly Leu  Pro Gly Pro Pro Gly  Pro Gln Gly Glu Ser  Arg Thr Gly 
    1835                 1840                 1845             


Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1850                 1855                 1860             


Arg Pro  Gly Asn Ser Gly Ile  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1865                 1870                 1875             


Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile Pro Tyr  Asn Gly Gln 
    1880                 1885                 1890             


Gly Tyr  Pro Gly Ser Gly 
    1895                 


<210> 230
<211> 3063
<212> PRT
<213> Homo sapiens

<400> 230
Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Arg  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Gly Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210> 231
<211> 477
<212> PRT
<213> Homo sapiens

<400> 231
Met Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys 
1               5                   10                  15      


Gly Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Leu Leu Pro Leu 
            20                  25                  30          


Leu Asn Ser Val Arg Leu Ala Pro Pro Pro Val Ile Lys Arg Arg Thr 
        35                  40                  45              


Phe Gln Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro 
65                  70                  75                  80  


Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly 
                85                  90                  95      


Asp Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met 
            100                 105                 110         


Pro Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala 
        115                 120                 125             


Val Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu 
    130                 135                 140                 


Lys Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys 
145                 150                 155                 160 


Gly Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu 
                165                 170                 175     


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala 
            180                 185                 190         


Gly Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly 
        195                 200                 205             


Glu Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser 
    210                 215                 220                 


Lys Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile 
225                 230                 235                 240 


Asn Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro 
                245                 250                 255     


Gly Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly 
            260                 265                 270         


Gln Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu 
        275                 280                 285             


Lys Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln 
    290                 295                 300                 


Gly Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly 
305                 310                 315                 320 


His Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln 
                325                 330                 335     


Ala Gly Ser Pro Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly 
            340                 345                 350         


Pro Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu 
        355                 360                 365             


Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg 
    370                 375                 380                 


Gly Pro Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly 
385                 390                 395                 400 


Pro Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met 
                405                 410                 415     


Thr Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro 
            420                 425                 430         


Gly Asp Lys Gly Asn Arg Gly His Arg Gly Phe Lys Gly Glu Lys Gly 
        435                 440                 445             


Glu Pro Gly Leu Pro Gly Leu Asp Gly Leu Asp Ala Pro Cys Pro Leu 
    450                 455                 460                 


Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
465                 470                 475         


<210> 232
<211> 651
<212> PRT
<213> Homo sapiens

<400> 232
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Val Lys Gly Gln Pro Gly Glu Lys Gly Ser 
    130                 135                 140                 


Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly 
145                 150                 155                 160 


Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu 
                165                 170                 175     


Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr 
            180                 185                 190         


Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly 
        195                 200                 205             


Gln Cys Gly Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val 
    210                 215                 220                 


Arg Leu Ala Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu 
225                 230                 235                 240 


Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly 
            260                 265                 270         


Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile 
        275                 280                 285             


Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro 
    290                 295                 300                 


Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu 
                325                 330                 335     


Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly 
            340                 345                 350         


Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro 
        355                 360                 365             


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly 
    370                 375                 380                 


Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala 
385                 390                 395                 400 


Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro 
                405                 410                 415     


Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu 
            420                 425                 430         


Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly 
        435                 440                 445             


Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu 
    450                 455                 460                 


Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg 
465                 470                 475                 480 


Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                485                 490                 495     


Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser 
            500                 505                 510         


Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro 
        515                 520                 525             


Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly 
    530                 535                 540                 


Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro 
545                 550                 555                 560 


Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala 
                565                 570                 575     


Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly 
            580                 585                 590         


Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp 
        595                 600                 605             


Lys Gly Asn Arg Gly His Arg Gly Phe Lys Gly Glu Lys Gly Glu Pro 
    610                 615                 620                 


Gly Leu Pro Gly Leu Asp Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu 
625                 630                 635                 640 


Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
                645                 650     


<210> 233
<211> 728
<212> PRT
<213> Homo sapiens

<400> 233
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Val Lys Gly Gln Pro Gly Glu Lys Gly Ser Pro Gly Asp Ala 
145                 150                 155                 160 


Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly Gln Pro Gly Thr 
                165                 170                 175     


Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys Pro 
            180                 185                 190         


Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro Gly 
        195                 200                 205             


Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly Glu 
    210                 215                 220                 


Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala Pro 
225                 230                 235                 240 


Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala 
                245                 250                 255     


Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly 
            260                 265                 270         


Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly Leu 
        275                 280                 285             


Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr His 
    290                 295                 300                 


Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His Gly 
305                 310                 315                 320 


Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu Pro 
                325                 330                 335     


Gly Ile Pro Gly Thr Lys Gly Asp Pro Gly Ala Glu Gly Lys Pro Gly 
            340                 345                 350         


Pro Pro Gly Leu Leu Gly Lys Arg Gly Gln Arg Gly Glu Lys Gly Ala 
        355                 360                 365             


Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys 
    370                 375                 380                 


Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp 
                405                 410                 415     


Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly 
            420                 425                 430         


Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu 
        435                 440                 445             


Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala 
    450                 455                 460                 


Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly 
                485                 490                 495     


Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro 
            500                 505                 510         


Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro 
        515                 520                 525             


Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly 
    530                 535                 540                 


Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Glu Lys Gly Glu Ala Gly Glu Lys Gly Asn Pro Gly Ala Glu 
                565                 570                 575     


Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu 
            580                 585                 590         


Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys 
        595                 600                 605             


Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly 
    610                 615                 620                 


Leu Pro Gly Ala Ser Gly Leu Asp Gly Arg Pro Gly Pro Pro Gly Thr 
625                 630                 635                 640 


Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg 
                645                 650                 655     


Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly 
            660                 665                 670         


Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly Glu 
        675                 680                 685             


Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly Asp Lys Gly Asp Gln 
    690                 695                 700                 


Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp Gly Leu 
705                 710                 715                 720 


Pro Val Gln Gly Cys Trp Asn Lys 
                725             


<210> 234
<211> 680
<212> PRT
<213> Homo sapiens

<400> 234
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Val Lys Gly Gln Pro Gly Glu Lys Gly Ser Pro Gly Asp Ala 
145                 150                 155                 160 


Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly Gln Pro Gly Thr 
                165                 170                 175     


Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys Pro 
            180                 185                 190         


Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro Gly 
        195                 200                 205             


Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly Glu 
    210                 215                 220                 


Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala Pro 
225                 230                 235                 240 


Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala 
                245                 250                 255     


Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly 
            260                 265                 270         


Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly Leu 
        275                 280                 285             


Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr His 
    290                 295                 300                 


Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His Gly 
305                 310                 315                 320 


Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu Pro 
                325                 330                 335     


Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu Gly Ser Pro Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly Asp Ala Gly Asn 
        355                 360                 365             


Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly 
    370                 375                 380                 


Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly Gln Val Gly Pro 
385                 390                 395                 400 


Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala Ala Gly Glu Gln 
                405                 410                 415     


Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro Gly Lys Gly Glu 
            420                 425                 430         


Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu Gln Glu Ile Arg 
        435                 440                 445             


Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly Gln Ile Gly Pro 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu Ile Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg Gly Lys Pro Gly 
                485                 490                 495     


Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly Pro 
            500                 505                 510         


Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser Pro Gly Glu Lys 
        515                 520                 525             


Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro Val Pro Gly Leu 
    530                 535                 540                 


Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Val Pro 
545                 550                 555                 560 


Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly 
                565                 570                 575     


Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu Pro Gly Thr 
            580                 585                 590         


Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg 
        595                 600                 605             


Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly 
    610                 615                 620                 


Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly Glu 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly Asp Lys Gly Asp Gln 
                645                 650                 655     


Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp Gly Leu 
            660                 665                 670         


Pro Val Gln Gly Cys Trp Asn Lys 
        675                 680 


<210> 235
<211> 657
<212> PRT
<213> Homo sapiens

<400> 235
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Ser Pro Gly 
        115                 120                 125             


Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly Gln Pro 
    130                 135                 140                 


Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly 
145                 150                 155                 160 


Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro 
                165                 170                 175     


Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys 
            180                 185                 190         


Gly Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu 
        195                 200                 205             


Ala Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser 
    210                 215                 220                 


Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro 
                245                 250                 255     


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly 
            260                 265                 270         


Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys 
        275                 280                 285             


His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly 
    290                 295                 300                 


Glu Pro Gly Ile Pro Gly Thr Lys Gly Asp Pro Gly Ala Glu Gly Lys 
305                 310                 315                 320 


Pro Gly Pro Pro Gly Leu Leu Gly Lys Arg Gly Gln Arg Gly Glu Lys 
                325                 330                 335     


Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly 
            340                 345                 350         


Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro 
        355                 360                 365             


Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly 
    370                 375                 380                 


Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu 
385                 390                 395                 400 


Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys 
                405                 410                 415     


Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn 
            420                 425                 430         


Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly 
        435                 440                 445             


Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln 
    450                 455                 460                 


Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys 
465                 470                 475                 480 


Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly 
                485                 490                 495     


Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His 
            500                 505                 510         


Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala 
        515                 520                 525             


Gly Ser Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly 
    530                 535                 540                 


Leu Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp 
545                 550                 555                 560 


Arg Gly Pro Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro 
                565                 570                 575     


Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly 
            580                 585                 590         


Met Thr Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro 
        595                 600                 605             


Pro Gly Asp Lys Gly Asn Arg Gly Glu Arg Gly Lys Lys Gly Ser Arg 
    610                 615                 620                 


Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Ala Pro Gly Leu Asp Ala 
625                 630                 635                 640 


Pro Cys Pro Leu Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn 
                645                 650                 655     


Lys 
    


<210> 236
<211> 619
<212> PRT
<213> Homo sapiens

<400> 236
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Gln Pro Gly 
        115                 120                 125             


Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys 
    130                 135                 140                 


Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly 
                165                 170                 175     


Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala 
            180                 185                 190         


Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln 
        195                 200                 205             


Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser 
    210                 215                 220                 


Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly 
225                 230                 235                 240 


Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr 
                245                 250                 255     


His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His 
            260                 265                 270         


Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu 
        275                 280                 285             


Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu Gly Ser Pro 
    290                 295                 300                 


Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly Asp Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro 
                325                 330                 335     


Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly Gln Val Gly 
            340                 345                 350         


Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala Ala Gly Glu 
        355                 360                 365             


Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro Gly Lys Gly 
    370                 375                 380                 


Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu Gln Glu Ile 
385                 390                 395                 400 


Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly Gln Ile Gly 
                405                 410                 415     


Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu Ile Gly Leu 
            420                 425                 430         


Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg Gly Lys Pro 
        435                 440                 445             


Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly 
    450                 455                 460                 


Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser Pro Gly Glu 
465                 470                 475                 480 


Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro Gly Glu Lys 
                485                 490                 495     


Gly Glu Ala Gly Glu Lys Gly Asn Pro Gly Ala Glu Val Pro Gly Leu 
            500                 505                 510         


Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Val Pro 
        515                 520                 525             


Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly 
    530                 535                 540                 


Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu Pro Gly Thr 
545                 550                 555                 560 


Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg 
                565                 570                 575     


Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly 
            580                 585                 590         


Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly Glu 
        595                 600                 605             


Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
    610                 615                 


<210> 237
<211> 625
<212> PRT
<213> Homo sapiens

<400> 237
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe 
    130                 135                 140                 


Pro Gly Pro Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys 
145                 150                 155                 160 


Gly Asp Met Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly 
                165                 170                 175     


Gln Lys Gly Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Leu Leu 
            180                 185                 190         


Pro Leu Leu Asn Ser Val Arg Leu Ala Pro Pro Pro Val Ile Lys Arg 
        195                 200                 205             


Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro 
    210                 215                 220                 


Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly 
225                 230                 235                 240 


Leu Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro 
                245                 250                 255     


Lys Gly Asp Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg 
            260                 265                 270         


Gly Met Pro Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly 
        275                 280                 285             


Ile Ala Val Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys 
    290                 295                 300                 


Gly Glu Lys Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly 
305                 310                 315                 320 


Gln Lys Gly Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg 
                325                 330                 335     


Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly 
            340                 345                 350         


Glu Ala Gly Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp 
        355                 360                 365             


Lys Gly Glu Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys 
    370                 375                 380                 


Gly Ser Lys Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly 
385                 390                 395                 400 


Asn Ile Asn Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly 
                405                 410                 415     


Pro Pro Gly Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile 
            420                 425                 430         


Pro Gly Gln Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp 
        435                 440                 445             


Gly Glu Lys Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly 
    450                 455                 460                 


Pro Gln Gly Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu 
465                 470                 475                 480 


Asn Gly His Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr 
                485                 490                 495     


Gly Gln Ala Gly Ser Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly 
            500                 505                 510         


Glu Ala Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu 
        515                 520                 525             


Lys Gly Asp Arg Gly Pro Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile 
    530                 535                 540                 


Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly 
545                 550                 555                 560 


Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu 
                565                 570                 575     


His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly His Arg Gly Phe Lys 
            580                 585                 590         


Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Leu Asp Gly Leu Asp Ala 
        595                 600                 605             


Pro Cys Pro Leu Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn 
    610                 615                 620                 


Lys 
625 


<210> 238
<211> 628
<212> PRT
<213> Homo sapiens

<400> 238
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Gln Pro Gly 
        115                 120                 125             


Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys 
    130                 135                 140                 


Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly 
                165                 170                 175     


Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala 
            180                 185                 190         


Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln 
        195                 200                 205             


Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser 
    210                 215                 220                 


Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly 
225                 230                 235                 240 


Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr 
                245                 250                 255     


His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His 
            260                 265                 270         


Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu 
        275                 280                 285             


Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu Gly Ser Pro 
    290                 295                 300                 


Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly Asp Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro 
                325                 330                 335     


Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly Gln Val Gly 
            340                 345                 350         


Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala Ala Gly Glu 
        355                 360                 365             


Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro Gly Lys Gly 
    370                 375                 380                 


Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu Gln Glu Ile 
385                 390                 395                 400 


Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly Gln Ile Gly 
                405                 410                 415     


Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu Ile Gly Leu 
            420                 425                 430         


Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg Gly Lys Pro 
        435                 440                 445             


Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly 
    450                 455                 460                 


Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser Pro Gly Glu 
465                 470                 475                 480 


Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro Gly Leu Gln 
                485                 490                 495     


Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly 
            500                 505                 510         


Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu 
        515                 520                 525             


Pro Gly Ala Ser Gly Leu Asp Gly Arg Pro Gly Pro Pro Gly Thr Pro 
    530                 535                 540                 


Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly Leu 
                565                 570                 575     


Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly His Arg 
            580                 585                 590         


Gly Phe Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Leu Asp Gly 
        595                 600                 605             


Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp Gly Leu Pro Val Gln Gly 
    610                 615                 620                 


Cys Trp Asn Lys 
625             


<210> 239
<211> 666
<212> PRT
<213> Homo sapiens

<400> 239
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Val Lys Gly Gln Pro Gly Glu Lys Gly Ser Pro Gly Asp Ala 
145                 150                 155                 160 


Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly Gln Pro Gly Thr 
                165                 170                 175     


Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys Pro 
            180                 185                 190         


Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro Gly 
        195                 200                 205             


Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly Glu 
    210                 215                 220                 


Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala Pro 
225                 230                 235                 240 


Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala 
                245                 250                 255     


Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly 
            260                 265                 270         


Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly Leu 
        275                 280                 285             


Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr His 
    290                 295                 300                 


Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His Gly 
305                 310                 315                 320 


Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu Pro 
                325                 330                 335     


Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu Gly Ser Pro Gly 
            340                 345                 350         


Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly Asp Ala Gly Asn 
        355                 360                 365             


Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly 
    370                 375                 380                 


Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly Gln Val Gly Pro 
385                 390                 395                 400 


Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala Ala Gly Glu Gln 
                405                 410                 415     


Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro Gly Lys Gly Glu 
            420                 425                 430         


Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu Gln Glu Ile Arg 
        435                 440                 445             


Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly Gln Ile Gly Pro 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu Ile Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg Gly Lys Pro Gly 
                485                 490                 495     


Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly Pro 
            500                 505                 510         


Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser Pro Gly Glu Lys 
        515                 520                 525             


Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro Gly Leu Gln Gly 
    530                 535                 540                 


Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly Glu 
545                 550                 555                 560 


Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu Pro 
                565                 570                 575     


Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly 
            580                 585                 590         


Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala 
        595                 600                 605             


Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg 
    610                 615                 620                 


Gly Glu Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly Asp Lys Gly 
625                 630                 635                 640 


Asp Gln Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp 
                645                 650                 655     


Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
            660                 665     


<210> 240
<211> 684
<212> PRT
<213> Homo sapiens

<400> 240
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Val Lys Gly Gln Pro Gly Glu Lys Gly Ser 
    130                 135                 140                 


Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly Pro Pro Gly 
145                 150                 155                 160 


Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu 
                165                 170                 175     


Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr 
            180                 185                 190         


Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly 
        195                 200                 205             


Gln Cys Gly Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val 
    210                 215                 220                 


Arg Leu Ala Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu 
225                 230                 235                 240 


Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly 
            260                 265                 270         


Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile 
        275                 280                 285             


Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro 
    290                 295                 300                 


Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Asp Pro Gly Ala Glu 
                325                 330                 335     


Gly Lys Pro Gly Pro Pro Gly Leu Leu Gly Lys Arg Gly Gln Arg Gly 
            340                 345                 350         


Glu Lys Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln 
        355                 360                 365             


Lys Gly Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly 
    370                 375                 380                 


Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu 
385                 390                 395                 400 


Ala Gly Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys 
                405                 410                 415     


Gly Glu Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly 
            420                 425                 430         


Ser Lys Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn 
        435                 440                 445             


Ile Asn Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro 
    450                 455                 460                 


Pro Gly Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro 
465                 470                 475                 480 


Gly Gln Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly 
                485                 490                 495     


Glu Lys Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro 
            500                 505                 510         


Gln Gly Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn 
        515                 520                 525             


Gly His Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly 
    530                 535                 540                 


Gln Ala Gly Ser Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu 
545                 550                 555                 560 


Ala Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys 
                565                 570                 575     


Gly Asp Arg Gly Pro Leu Gly Leu Pro Gly Ala Ser Gly Leu Asp Gly 
            580                 585                 590         


Arg Pro Gly Pro Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro 
        595                 600                 605             


Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr 
    610                 615                 620                 


Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly 
625                 630                 635                 640 


Asp Lys Gly Asn Arg Gly His Arg Gly Phe Lys Gly Glu Lys Gly Glu 
                645                 650                 655     


Pro Gly Leu Pro Gly Leu Asp Gly Leu Asp Ala Pro Cys Pro Leu Gly 
            660                 665                 670         


Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
        675                 680                 


<210> 241
<211> 645
<212> PRT
<213> Homo sapiens

<400> 241
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Gln Pro Gly 
        115                 120                 125             


Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro Ile Gly Leu Asp Gly Lys 
    130                 135                 140                 


Pro Gly His Pro Gly Pro Lys Gly Asp Met Gly Leu Thr Gly Pro Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly Glu Lys Gly Gln Cys Gly 
                165                 170                 175     


Glu Tyr Pro His Arg Leu Leu Pro Leu Leu Asn Ser Val Arg Leu Ala 
            180                 185                 190         


Pro Pro Pro Val Ile Lys Arg Arg Thr Phe Gln Gly Glu Gln Ser Gln 
        195                 200                 205             


Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser 
    210                 215                 220                 


Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly Pro Pro Gly 
225                 230                 235                 240 


Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile Gln Gly Tyr 
                245                 250                 255     


His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro Gly Lys His 
            260                 265                 270         


Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met Lys Gly Glu 
        275                 280                 285             


Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu Gly Ser Pro 
    290                 295                 300                 


Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly Asp Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro 
                325                 330                 335     


Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly Gln Val Gly 
            340                 345                 350         


Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala Ala Gly Glu 
        355                 360                 365             


Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro Gly Lys Gly 
    370                 375                 380                 


Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu Gln Glu Ile 
385                 390                 395                 400 


Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly Gln Ile Gly 
                405                 410                 415     


Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu Ile Gly Leu 
            420                 425                 430         


Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg Gly Lys Pro 
        435                 440                 445             


Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly 
    450                 455                 460                 


Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser Pro Gly Glu 
465                 470                 475                 480 


Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro Val Pro Gly 
                485                 490                 495     


Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Val 
            500                 505                 510         


Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly Glu Lys 
        515                 520                 525             


Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu Pro Gly 
    530                 535                 540                 


Ala Ser Gly Leu Asp Gly Arg Pro Gly Pro Pro Gly Thr Pro Gly Pro 
545                 550                 555                 560 


Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys 
                565                 570                 575     


Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly 
            580                 585                 590         


Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly Glu Arg Gly Lys 
        595                 600                 605             


Lys Gly Ser Arg Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Ala Pro 
    610                 615                 620                 


Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp Gly Leu Pro Val Gln 
625                 630                 635                 640 


Gly Cys Trp Asn Lys 
                645 


<210> 242
<211> 686
<212> PRT
<213> Homo sapiens

<400> 242
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Ser Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly 
145                 150                 155                 160 


Pro Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro 
                165                 170                 175     


Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met 
            180                 185                 190         


Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly 
        195                 200                 205             


Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Leu Leu Pro Leu Leu 
    210                 215                 220                 


Asn Ser Val Arg Leu Ala Pro Pro Pro Val Ile Lys Arg Arg Thr Phe 
225                 230                 235                 240 


Gln Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly 
            260                 265                 270         


Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp 
        275                 280                 285             


Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro 
    290                 295                 300                 


Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val 
305                 310                 315                 320 


Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys 
                325                 330                 335     


Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly 
            340                 345                 350         


Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro 
        355                 360                 365             


Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly 
    370                 375                 380                 


Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu 
385                 390                 395                 400 


Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys 
                405                 410                 415     


Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn 
            420                 425                 430         


Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly 
        435                 440                 445             


Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln 
    450                 455                 460                 


Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys 
465                 470                 475                 480 


Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly 
                485                 490                 495     


Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His 
            500                 505                 510         


Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala 
        515                 520                 525             


Gly Ser Pro Gly Glu Lys Gly Glu Ala Gly Glu Lys Gly Asn Pro Gly 
    530                 535                 540                 


Ala Glu Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro 
545                 550                 555                 560 


Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly 
                565                 570                 575     


Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro 
            580                 585                 590         


Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala 
        595                 600                 605             


Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly 
    610                 615                 620                 


Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp 
625                 630                 635                 640 


Lys Gly Asn Arg Gly Glu Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys 
                645                 650                 655     


Gly Asp Lys Gly Asp Gln Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro 
            660                 665                 670         


Leu Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
        675                 680                 685     


<210> 243
<211> 668
<212> PRT
<213> Homo sapiens

<400> 243
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Ser Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly 
145                 150                 155                 160 


Pro Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro 
                165                 170                 175     


Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met 
            180                 185                 190         


Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly 
        195                 200                 205             


Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Glu Cys Leu Ser Ser 
    210                 215                 220                 


Met Pro Ala Ala Leu Arg Ser Ser Gln Ile Ile Ala Leu Lys Gly Glu 
225                 230                 235                 240 


Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly 
            260                 265                 270         


Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile 
        275                 280                 285             


Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro 
    290                 295                 300                 


Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu 
                325                 330                 335     


Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly 
            340                 345                 350         


Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro 
        355                 360                 365             


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly 
    370                 375                 380                 


Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala 
385                 390                 395                 400 


Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro 
                405                 410                 415     


Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu 
            420                 425                 430         


Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly 
        435                 440                 445             


Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu 
    450                 455                 460                 


Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg 
465                 470                 475                 480 


Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                485                 490                 495     


Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser 
            500                 505                 510         


Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro 
        515                 520                 525             


Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu 
    530                 535                 540                 


Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys 
545                 550                 555                 560 


Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly 
                565                 570                 575     


Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro 
            580                 585                 590         


Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr 
        595                 600                 605             


Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly 
    610                 615                 620                 


Asn Arg Gly Glu Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly Asp 
625                 630                 635                 640 


Lys Gly Asp Gln Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu Gly 
                645                 650                 655     


Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
            660                 665             


<210> 244
<211> 610
<212> PRT
<213> Homo sapiens

<400> 244
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe 
    130                 135                 140                 


Pro Gly Pro Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys 
145                 150                 155                 160 


Gly Asp Met Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly 
                165                 170                 175     


Gln Lys Gly Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Glu Cys 
            180                 185                 190         


Leu Ser Ser Met Pro Ala Ala Leu Arg Ser Ser Gln Ile Ile Ala Leu 
        195                 200                 205             


Lys Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro 
    210                 215                 220                 


Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly 
225                 230                 235                 240 


Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp 
                245                 250                 255     


Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro 
            260                 265                 270         


Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val 
        275                 280                 285             


Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro 
                325                 330                 335     


Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly 
            340                 345                 350         


Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu 
        355                 360                 365             


Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys 
    370                 375                 380                 


Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn 
385                 390                 395                 400 


Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly 
                405                 410                 415     


Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln 
            420                 425                 430         


Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys 
        435                 440                 445             


Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly 
    450                 455                 460                 


Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His 
465                 470                 475                 480 


Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala 
                485                 490                 495     


Gly Ser Pro Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro 
            500                 505                 510         


Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp 
        515                 520                 525             


Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly 
    530                 535                 540                 


Pro Leu Gly Leu Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr 
                565                 570                 575     


Gly Pro Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly 
            580                 585                 590         


Asp Lys Gly Asn Arg Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp 
        595                 600                 605             


Asn Lys 
    610 


<210> 245
<211> 695
<212> PRT
<213> Homo sapiens

<400> 245
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Ser Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly 
145                 150                 155                 160 


Pro Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro 
                165                 170                 175     


Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met 
            180                 185                 190         


Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly 
        195                 200                 205             


Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Glu Cys Leu Ser Ser 
    210                 215                 220                 


Met Pro Ala Ala Leu Arg Ser Ser Gln Ile Ile Ala Leu Lys Gly Glu 
225                 230                 235                 240 


Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ser Gly Pro Leu Gly His Pro Gly Leu Pro Gly Pro Met Gly 
            260                 265                 270         


Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ile 
        275                 280                 285             


Gln Gly Tyr His Gly Arg Lys Gly Glu Arg Gly Met Pro Gly Met Pro 
    290                 295                 300                 


Gly Lys His Gly Ala Lys Gly Ala Pro Gly Ile Ala Val Ala Gly Met 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys Gly Glu Lys Gly Ala Glu 
                325                 330                 335     


Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly Gln Lys Gly Glu Lys Gly 
            340                 345                 350         


Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg Gly Glu Pro Gly Pro Pro 
        355                 360                 365             


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Val Asp Gly 
    370                 375                 380                 


Gln Val Gly Pro Pro Gly Gln Pro Gly Asp Lys Gly Glu Arg Gly Ala 
385                 390                 395                 400 


Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys Gly Ser Lys Gly Glu Pro 
                405                 410                 415     


Gly Lys Gly Glu Met Val Asp Tyr Asn Gly Asn Ile Asn Glu Ala Leu 
            420                 425                 430         


Gln Glu Ile Arg Thr Leu Ala Leu Met Gly Pro Pro Gly Leu Pro Gly 
        435                 440                 445             


Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile Pro Gly Gln Lys Gly Glu 
    450                 455                 460                 


Ile Gly Leu Pro Gly Pro Pro Gly His Asp Gly Glu Lys Gly Pro Arg 
465                 470                 475                 480 


Gly Lys Pro Gly Asp Met Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                485                 490                 495     


Lys Asp Gly Pro Pro Gly Val Lys Gly Glu Asn Gly His Pro Gly Ser 
            500                 505                 510         


Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr Gly Gln Ala Gly Ser Pro 
        515                 520                 525             


Gly Glu Lys Gly Glu Ala Gly Glu Lys Gly Asn Pro Gly Ala Glu Val 
    530                 535                 540                 


Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro Gly Pro Pro Gly Leu Gln 
545                 550                 555                 560 


Gly Val Pro Gly Pro Lys Gly Glu Ala Gly Leu Asp Gly Ala Lys Gly 
                565                 570                 575     


Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp Arg Gly Pro Leu Gly Leu 
            580                 585                 590         


Pro Gly Ala Ser Gly Leu Asp Gly Arg Pro Gly Pro Pro Gly Thr Pro 
        595                 600                 605             


Gly Pro Ile Gly Val Pro Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly 
    610                 615                 620                 


Ser Lys Gly Asp Pro Gly Met Thr Gly Pro Thr Gly Ala Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Leu His Gly Pro Pro Gly Asp Lys Gly Asn Arg Gly Glu Arg 
                645                 650                 655     


Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly 
            660                 665                 670         


Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu Gly Glu Asp Gly Leu Pro 
        675                 680                 685             


Val Gln Gly Cys Trp Asn Lys 
    690                 695 


<210> 246
<211> 717
<212> PRT
<213> Homo sapiens

<400> 246
Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Ser Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly 
145                 150                 155                 160 


Pro Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro 
                165                 170                 175     


Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met 
            180                 185                 190         


Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly 
        195                 200                 205             


Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Glu Cys Leu Ser Ser 
    210                 215                 220                 


Met Pro Ala Ala Leu Arg Ser Ser Gln Ile Ile Ala Leu Lys Leu Leu 
225                 230                 235                 240 


Pro Leu Leu Asn Ser Val Arg Leu Ala Pro Pro Pro Val Ile Lys Arg 
                245                 250                 255     


Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly 
        275                 280                 285             


Leu Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Met Pro Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly 
                325                 330                 335     


Ile Ala Val Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys 
            340                 345                 350         


Gly Glu Lys Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly 
        355                 360                 365             


Gln Lys Gly Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg 
    370                 375                 380                 


Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly 
385                 390                 395                 400 


Glu Ala Gly Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp 
                405                 410                 415     


Lys Gly Glu Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys 
            420                 425                 430         


Gly Ser Lys Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly 
        435                 440                 445             


Asn Ile Asn Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly 
    450                 455                 460                 


Pro Pro Gly Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile 
465                 470                 475                 480 


Pro Gly Gln Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp 
                485                 490                 495     


Gly Glu Lys Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly 
            500                 505                 510         


Pro Gln Gly Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu 
        515                 520                 525             


Asn Gly His Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr 
    530                 535                 540                 


Gly Gln Ala Gly Ser Pro Gly Glu Lys Gly Glu Ala Gly Glu Lys Gly 
545                 550                 555                 560 


Asn Pro Gly Ala Glu Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro 
                565                 570                 575     


Gly Pro Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly 
            580                 585                 590         


Leu Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp 
        595                 600                 605             


Arg Gly Pro Leu Gly Leu Pro Gly Ala Ser Gly Leu Asp Gly Arg Pro 
    610                 615                 620                 


Gly Pro Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly 
625                 630                 635                 640 


Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro 
                645                 650                 655     


Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys 
            660                 665                 670         


Gly Asn Arg Gly Glu Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly 
        675                 680                 685             


Asp Lys Gly Asp Gln Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu 
    690                 695                 700                 


Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
705                 710                 715         


<210> 247
<211> 1796
<212> PRT
<213> Homo sapiens

<400> 247
Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Ala Pro His 
    1760                 1765                 1770             


Pro Asp  Gln Pro Glu Phe Thr  Pro Val Gln Asp Glu  Leu Glu Ala 
    1775                 1780                 1785             


Met Glu  Leu Trp Gly Pro Gly  Val 
    1790                 1795     


<210> 248
<211> 1604
<212> PRT
<213> Homo sapiens

<400> 248
Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Thr Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr 
            100                 105                 110         


His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Thr Ala Cys Pro Ser Leu Gln Gly Thr Val Thr Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Thr Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Thr 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly Thr Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Ala Pro Gly Leu Trp 
                885                 890                 895     


Met Gly Ser Ser Trp Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro 
            900                 905                 910         


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Gly Val Pro Gly 
        915                 920                 925             


Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Thr Ala Glu Leu Gly Ser 
    930                 935                 940                 


Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile Cys Gly Asp Cys Val 
945                 950                 955                 960 


Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val Glu Lys Gly Glu Lys 
                965                 970                 975     


Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu Asp Asn Cys Ala Gln 
            980                 985                 990         


Cys Phe Leu Ser Leu Glu Arg Pro  Arg Ala Glu Glu Ala  Arg Gly Asp 
        995                 1000                 1005             


Asn Ser  Glu Gly Asp Pro Gly  Cys Val Gly Ser Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Leu Pro Gly  Gln Arg Gly Glu Glu  Gly Pro Pro 
    1025                 1030                 1035             


Gly Met  Arg Gly Ser Pro Gly  Pro Pro Gly Pro Ile  Gly Pro Pro 
    1040                 1045                 1050             


Gly Phe  Pro Gly Ala Val Gly  Ser Pro Gly Leu Pro  Gly Leu Gln 
    1055                 1060                 1065             


Gly Glu  Arg Gly Leu Thr Gly  Leu Thr Gly Asp Lys  Gly Glu Pro 
    1070                 1075                 1080             


Gly Pro  Pro Gly Gln Pro Gly  Tyr Pro Gly Ala Thr  Gly Pro Pro 
    1085                 1090                 1095             


Gly Leu  Pro Gly Ile Lys Gly  Glu Arg Gly Tyr Thr  Gly Ser Ala 
    1100                 1105                 1110             


Gly Glu  Lys Gly Glu Pro Gly  Pro Pro Gly Ser Glu  Gly Leu Pro 
    1115                 1120                 1125             


Gly Pro  Pro Gly Pro Ala Gly  Pro Arg Gly Glu Arg  Gly Pro Gln 
    1130                 1135                 1140             


Gly Asn  Ser Gly Glu Lys Gly  Asp Gln Gly Phe Gln  Gly Gln Pro 
    1145                 1150                 1155             


Gly Phe  Pro Gly Pro Pro Gly  Pro Pro Gly Phe Pro  Gly Lys Val 
    1160                 1165                 1170             


Gly Ser  Pro Gly Pro Pro Gly  Pro Gln Ala Glu Lys  Gly Ser Glu 
    1175                 1180                 1185             


Gly Ile  Arg Gly Pro Ser Gly  Leu Pro Gly Ser Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Ile Gln Gly  Pro Ala Gly Leu Asp  Gly Leu Asp 
    1205                 1210                 1215             


Gly Lys  Asp Gly Lys Pro Gly  Leu Arg Gly Asp Pro  Gly Pro Ala 
    1220                 1225                 1230             


Gly Pro  Pro Gly Leu Met Gly  Pro Pro Gly Phe Lys  Gly Lys Thr 
    1235                 1240                 1245             


Gly His  Pro Gly Leu Pro Gly  Pro Lys Gly Asp Cys  Gly Lys Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Ser Thr Gly  Arg Pro Gly Ala Glu  Gly Glu Pro 
    1265                 1270                 1275             


Gly Ala  Met Gly Pro Gln Gly  Arg Pro Gly Pro Pro  Gly His Val 
    1280                 1285                 1290             


Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly Pro Ala  Gly Ile Ser 
    1295                 1300                 1305             


Ala Val  Gly Leu Lys Gly Asp  Arg Gly Ala Thr Gly  Glu Arg Gly 
    1310                 1315                 1320             


Leu Ala  Gly Leu Pro Gly Gln  Pro Gly Pro Pro Gly  His Pro Gly 
    1325                 1330                 1335             


Pro Pro  Gly Glu Pro Gly Thr  Asp Gly Ala Ala Gly  Lys Glu Gly 
    1340                 1345                 1350             


Pro Pro  Gly Lys Gln Gly Phe  Tyr Gly Pro Pro Gly  Pro Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Ala Ala Gly Gln  Lys Gly Gln Ala Gly  Glu Lys Gly 
    1370                 1375                 1380             


Arg Ala  Gly Met Pro Gly Gly  Pro Gly Lys Ser Gly  Ser Met Gly 
    1385                 1390                 1395             


Pro Val  Gly Pro Pro Gly Pro  Ala Gly Glu Arg Gly  His Pro Gly 
    1400                 1405                 1410             


Ala Pro  Gly Pro Ser Gly Ser  Pro Gly Leu Pro Gly  Val Pro Gly 
    1415                 1420                 1425             


Ser Met  Gly Asp Met Val Asn  Tyr Asp Glu Ile Lys  Arg Phe Ile 
    1430                 1435                 1440             


Arg Gln  Glu Ile Ile Lys Met  Phe Asp Glu Arg Met  Ala Tyr Tyr 
    1445                 1450                 1455             


Thr Ser  Arg Met Gln Phe Pro  Met Glu Met Ala Ala  Ala Pro Gly 
    1460                 1465                 1470             


Arg Pro  Gly Pro Pro Gly Lys  Asp Gly Ala Pro Gly  Arg Pro Gly 
    1475                 1480                 1485             


Ala Pro  Gly Ser Pro Gly Leu  Pro Gly Gln Ile Gly  Arg Glu Gly 
    1490                 1495                 1500             


Arg Gln  Gly Leu Pro Gly Val  Arg Gly Leu Pro Gly  Thr Lys Gly 
    1505                 1510                 1515             


Glu Lys  Gly Asp Ile Gly Ile  Gly Ile Ala Gly Glu  Asn Gly Leu 
    1520                 1525                 1530             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Tyr  Gly Lys Met 
    1535                 1540                 1545             


Gly Ala  Thr Gly Pro Met Gly  Gln Gln Gly Ile Pro  Gly Ile Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Met Gly  Gln Pro Gly Lys Ala  Gly His Cys 
    1565                 1570                 1575             


Asn Pro  Ser Asp Cys Phe Gly  Ala Met Pro Met Glu  Gln Gln Tyr 
    1580                 1585                 1590             


Pro Pro  Met Lys Thr Met Lys  Gly Pro Phe Gly 
    1595                 1600                 


<210> 249
<211> 1497
<212> PRT
<213> Homo sapiens

<400> 249
Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu 
1               5                   10                  15      


Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro 
            20                  25                  30          


Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly 
        35                  40                  45              


Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr 
    50                  55                  60                  


Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr 
65                  70                  75                  80  


Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser 
                85                  90                  95      


Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser 
            100                 105                 110         


Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser 
        115                 120                 125             


Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val 
    130                 135                 140                 


Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp 
145                 150                 155                 160 


Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr 
                165                 170                 175     


Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu 
            180                 185                 190         


Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp 
        195                 200                 205             


Ala Thr Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr 
    210                 215                 220                 


Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr 
225                 230                 235                 240 


Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val 
                245                 250                 255     


Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro 
            260                 265                 270         


Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala 
    290                 295                 300                 


Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr 
305                 310                 315                 320 


Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp 
                325                 330                 335     


Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr 
            340                 345                 350         


Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly 
        355                 360                 365             


Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser 
    370                 375                 380                 


Glu Asp Thr Leu Lys Lys Glu Lys Gln Ala Ala Tyr Asn Ala Asp Ser 
385                 390                 395                 400 


Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys 
                405                 410                 415     


Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Gly Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro 
        435                 440                 445             


Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp 
    450                 455                 460                 


Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly 
465                 470                 475                 480 


Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys 
                485                 490                 495     


Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr 
            500                 505                 510         


Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala 
        515                 520                 525             


Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser 
    530                 535                 540                 


Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln 
545                 550                 555                 560 


Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly 
                565                 570                 575     


Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile 
            580                 585                 590         


Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys 
        595                 600                 605             


Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly 
    610                 615                 620                 


Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser 
625                 630                 635                 640 


Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly 
                645                 650                 655     


Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser 
            660                 665                 670         


Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg 
        675                 680                 685             


Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu 
705                 710                 715                 720 


Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro 
                725                 730                 735     


Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly 
            740                 745                 750         


Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro 
        755                 760                 765             


Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln 
    770                 775                 780                 


Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly 
785                 790                 795                 800 


Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met 
                805                 810                 815     


Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro 
            820                 825                 830         


Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly 
        835                 840                 845             


His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe 
                885                 890                 895     


Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
        915                 920                 925             


Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser 
    930                 935                 940                 


Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly 
945                 950                 955                 960 


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile 
                965                 970                 975     


Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser 
            980                 985                 990         


Gly Pro Pro Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Ser Ile Ser 
        995                 1000                 1005             


Ser Ser  Gly Gln Glu Ile Gln  Gln Tyr Ile Ser Glu  Tyr Met Gln 
    1010                 1015                 1020             


Ser Asp  Ser Ile Arg Ser Tyr  Leu Ser Gly Val Gln  Gly Pro Pro 
    1025                 1030                 1035             


Gly Pro  Pro Gly Pro Pro Gly  Pro Val Thr Thr Ile  Thr Gly Glu 
    1040                 1045                 1050             


Thr Phe  Asp Tyr Ser Glu Leu  Ala Ser His Val Val  Ser Tyr Leu 
    1055                 1060                 1065             


Arg Thr  Ser Gly Tyr Gly Val  Ser Leu Phe Ser Ser  Ser Ile Ser 
    1070                 1075                 1080             


Ser Glu  Asp Ile Leu Ala Val  Leu Gln Arg Asp Asp  Val Arg Gln 
    1085                 1090                 1095             


Tyr Leu  Arg Gln Tyr Leu Met  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Ser Gly Asp Gly  Ser Leu Leu Ser Leu  Asp Tyr Ala 
    1115                 1120                 1125             


Glu Leu  Ser Ser Arg Ile Leu  Ser Tyr Met Ser Ser  Ser Gly Ile 
    1130                 1135                 1140             


Ser Ile  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly 
    1145                 1150                 1155             


Thr Ser  Tyr Glu Glu Leu Leu  Ser Leu Leu Arg Gly  Ser Glu Phe 
    1160                 1165                 1170             


Arg Gly  Ile Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ile 
    1175                 1180                 1185             


Pro Gly  Asn Val Trp Ser Ser  Ile Ser Val Glu Asp  Leu Ser Ser 
    1190                 1195                 1200             


Tyr Leu  His Thr Ala Gly Leu  Ser Phe Ile Pro Gly  Pro Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro Pro Gly  Val Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Thr Tyr Ala Ala  Glu Asn Ser Asp Ser  Phe Arg Ser 
    1235                 1240                 1245             


Glu Leu  Ile Ser Tyr Leu Thr  Ser Pro Asp Val Arg  Ser Phe Ile 
    1250                 1255                 1260             


Val Gly  Pro Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Asp 
    1265                 1270                 1275             


Ser Arg  Leu Leu Ser Thr Asp  Ala Ser His Ser Arg  Gly Ser Ser 
    1280                 1285                 1290             


Ser Ser  Ser His Ser Ser Ser  Val Arg Arg Gly Ser  Ser Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Met Ser Thr Gly Gly  Gly Gly Ala Gly Ser  Leu Gly Ala 
    1310                 1315                 1320             


Gly Gly  Ala Phe Gly Glu Ala  Ala Gly Asp Arg Gly  Pro Tyr Gly 
    1325                 1330                 1335             


Thr Asp  Ile Gly Pro Gly Gly  Gly Tyr Gly Ala Ala  Ala Glu Gly 
    1340                 1345                 1350             


Gly Met  Tyr Ala Gly Asn Gly  Gly Leu Leu Gly Ala  Asp Phe Ala 
    1355                 1360                 1365             


Gly Asp  Leu Asp Tyr Asn Glu  Leu Ala Val Arg Val  Ser Glu Ser 
    1370                 1375                 1380             


Met Gln  Arg Gln Gly Leu Leu  Gln Gly Met Ala Tyr  Thr Val Gln 
    1385                 1390                 1395             


Gly Pro  Pro Gly Gln Pro Gly  Pro Gln Gly Pro Pro  Gly Ile Ser 
    1400                 1405                 1410             


Lys Val  Phe Ser Ala Tyr Ser  Asn Val Thr Ala Asp  Leu Met Asp 
    1415                 1420                 1425             


Phe Phe  Gln Thr Tyr Gly Ala  Ile Gln Gly Pro Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Thr Pro Gly  Pro Lys Gly Asp Arg  Gly Pro Ala 
    1445                 1450                 1455             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Pro Arg  Gly His Lys 
    1460                 1465                 1470             


Gly Glu  Lys Gly Asp Lys Gly  Asp Gln Val Tyr Ala  Gly Arg Arg 
    1475                 1480                 1485             


Arg Arg  Arg Ser Ile Ala Val  Lys Pro 
    1490                 1495         


<210> 250
<211> 1516
<212> PRT
<213> Homo sapiens

<400> 250
Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 
    1115                 1120                 1125             


Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 
    1145                 1150                 1155             


Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1190                 1195                 1200             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1205                 1210                 1215             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1220                 1225                 1230             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1235                 1240                 1245             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1250                 1255                 1260             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1265                 1270                 1275             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1280                 1285                 1290             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1295                 1300                 1305             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1310                 1315                 1320             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1325                 1330                 1335             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1340                 1345                 1350             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1355                 1360                 1365             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1370                 1375                 1380             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1385                 1390                 1395             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1400                 1405                 1410             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1415                 1420                 1425             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1430                 1435                 1440             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1445                 1450                 1455             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1460                 1465                 1470             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1475                 1480                 1485             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1490                 1495                 1500             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1505                 1510                 1515     


<210> 251
<211> 1336
<212> PRT
<213> Homo sapiens

<400> 251
Met Ala Pro Arg Cys Pro Trp Pro Trp Pro Arg Arg Arg Arg Leu Leu 
1               5                   10                  15      


Asp Val Leu Ala Pro Leu Val Leu Leu Leu Gly Val Arg Ala Ala Ser 
            20                  25                  30          


Ala Glu Pro Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 
        35                  40                  45              


Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 
    50                  55                  60                  


Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 
65                  70                  75                  80  


Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 
                85                  90                  95      


His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr 
            100                 105                 110         


Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val 
        115                 120                 125             


Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala 
    130                 135                 140                 


Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly 
145                 150                 155                 160 


Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu 
                165                 170                 175     


Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 
            180                 185                 190         


Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 
        195                 200                 205             


Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 
    210                 215                 220                 


Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu 
225                 230                 235                 240 


Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly 
                245                 250                 255     


Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro 
            260                 265                 270         


Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly 
        275                 280                 285             


Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 
    290                 295                 300                 


Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser 
305                 310                 315                 320 


Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly 
                325                 330                 335     


Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly 
            340                 345                 350         


Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu 
        355                 360                 365             


Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr 
    370                 375                 380                 


Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr 
385                 390                 395                 400 


Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro 
                405                 410                 415     


Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 
            420                 425                 430         


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro 
        435                 440                 445             


Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu 
465                 470                 475                 480 


Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro 
                485                 490                 495     


Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser 
            500                 505                 510         


Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu 
        515                 520                 525             


Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    530                 535                 540                 


Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 
545                 550                 555                 560 


Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala 
                565                 570                 575     


Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro Gly Pro Ala Gly 
            580                 585                 590         


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Leu Pro 
        595                 600                 605             


Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro Phe Trp Ser Thr 
    610                 615                 620                 


Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Leu 
625                 630                 635                 640 


Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala Lys Gly Glu Val 
                645                 650                 655     


Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 
            660                 665                 670         


Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu 
        675                 680                 685             


Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu Pro Gly 
    690                 695                 700                 


Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu Gln Asp Gly 
705                 710                 715                 720 


Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly Phe Ala Gly 
                725                 730                 735     


Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly Ser Lys Gly Glu 
            740                 745                 750         


Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro Gly Ser Ile 
        755                 760                 765             


Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys Gly Ala Lys 
    770                 775                 780                 


Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 
785                 790                 795                 800 


Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly Met 
                805                 810                 815     


Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala Ser Leu Gly 
            820                 825                 830         


Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
        835                 840                 845             


Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe Ala Glu Ser 
    850                 855                 860                 


Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln Gly Pro Pro Gly 
865                 870                 875                 880 


Pro Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Gln 
                885                 890                 895     


Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys Gly Glu Lys 
            900                 905                 910         


Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 
        915                 920                 925             


Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro 
    930                 935                 940                 


Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly Glu Ser Ile 
945                 950                 955                 960 


Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Gly 
                965                 970                 975     


Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Ser Phe Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1010                 1015                 1020             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1025                 1030                 1035             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1040                 1045                 1050             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1055                 1060                 1065             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1070                 1075                 1080             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1085                 1090                 1095             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1100                 1105                 1110             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1115                 1120                 1125             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1130                 1135                 1140             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1145                 1150                 1155             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1160                 1165                 1170             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1175                 1180                 1185             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1190                 1195                 1200             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1205                 1210                 1215             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1220                 1225                 1230             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1235                 1240                 1245             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1250                 1255                 1260             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1265                 1270                 1275             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1280                 1285                 1290             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1295                 1300                 1305             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1310                 1315                 1320             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1325                 1330                 1335     


<210> 252
<211> 1751
<212> PRT
<213> Homo sapiens

<400> 252
Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Gly Arg Ala Ser Leu Ser Ser Leu Leu 
    210                 215                 220                 


Gly Gly Ala Pro Pro Trp Gly Ser Leu Gln Asp Pro Asp Ser Gln Gly 
225                 230                 235                 240 


Leu Ser Pro Ala Ala Ala Ala Pro Ser Gln Gln Leu Gln Arg Pro Asp 
                245                 250                 255     


Val Arg Leu Arg Thr Pro Leu Leu His Pro Leu Val Met Gly Ser Leu 
            260                 265                 270         


Gly Lys His Ala Ala Pro Ser Ala Phe Ser Ser Gly Leu Pro Gly Ala 
        275                 280                 285             


Leu Ser Gln Val Ala Val Thr Thr Leu Thr Arg Asp Ser Gly Ala Trp 
    290                 295                 300                 


Val Ser His Val Ala Asn Ser Val Gly Pro Gly Leu Ala Asn Asn Ser 
305                 310                 315                 320 


Ala Leu Leu Gly Ala Asp Pro Glu Ala Pro Ala Gly Arg Cys Leu Pro 
                325                 330                 335     


Leu Pro Pro Ser Leu Pro Val Cys Gly His Leu Gly Ile Ser Arg Phe 
            340                 345                 350         


Trp Leu Pro Asn His Leu His His Glu Ser Gly Glu Gln Val Arg Ala 
        355                 360                 365             


Gly Ala Arg Ala Trp Gly Gly Leu Leu Gln Thr His Cys His Pro Phe 
    370                 375                 380                 


Leu Ala Trp Phe Phe Cys Leu Leu Leu Val Pro Pro Cys Gly Ser Val 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Pro Pro Cys Cys Gln Phe Cys Glu Ala Leu Gln 
                405                 410                 415     


Asp Ala Cys Trp Ser Arg Leu Gly Gly Gly Arg Leu Pro Val Ala Cys 
            420                 425                 430         


Ala Ser Leu Pro Thr Gln Glu Asp Gly Tyr Cys Val Leu Ile Gly Pro 
        435                 440                 445             


Ala Ala Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu Gly 
    450                 455                 460                 


Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val Gly 
465                 470                 475                 480 


Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala Arg 
                485                 490                 495     


Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe His 
            500                 505                 510         


Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr Asp 
        515                 520                 525             


Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val Gln 
    530                 535                 540                 


Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala Gly 
545                 550                 555                 560 


Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly Gln 
                565                 570                 575     


Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu Tyr 
            580                 585                 590         


Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser Arg 
        595                 600                 605             


Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala Gly 
    610                 615                 620                 


Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys Val 
625                 630                 635                 640 


Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu Gly 
                645                 650                 655     


Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly Asp 
            660                 665                 670         


Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro Arg 
        675                 680                 685             


Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly Ser 
    690                 695                 700                 


Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr Val 
705                 710                 715                 720 


Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser Thr 
                725                 730                 735     


Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly Gly 
            740                 745                 750         


Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly Arg 
        755                 760                 765             


Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu Pro 
    770                 775                 780                 


Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr Val 
785                 790                 795                 800 


Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr Pro 
                805                 810                 815     


Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro Gly 
            820                 825                 830         


Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly Pro 
        835                 840                 845             


Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp Lys 
865                 870                 875                 880 


Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu Glu 
                885                 890                 895     


Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser Ser 
        915                 920                 925             


Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu Gly 
    930                 935                 940                 


Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Arg 
945                 950                 955                 960 


Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu Ala 
                965                 970                 975     


Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala Gly 
            980                 985                 990         


Ala Arg Gly Glu Ser Gly Leu Ala  Gly Ala Pro Gly Pro  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Gly Leu Pro 
    1010                 1015                 1020             


Ala Gly  Phe Asp Asp Met Glu  Gly Ser Gly Gly Pro  Phe Trp Ser 
    1025                 1030                 1035             


Thr Ala  Arg Ser Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Leu  Lys Gly Asp Pro Gly  Val Pro Gly Leu Pro  Gly Ala Lys 
    1055                 1060                 1065             


Gly Glu  Val Gly Ala Asp Gly  Val Pro Gly Phe Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Glu Gly Ile Ala Gly  Pro Gln Gly Pro Lys  Gly Asp Arg 
    1085                 1090                 1095             


Gly Ser  Arg Gly Glu Lys Gly  Asp Pro Gly Lys Asp  Gly Val Gly 
    1100                 1105                 1110             


Gln Pro  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Val Val 
    1115                 1120                 1125             


Tyr Val  Ser Glu Gln Asp Gly  Ser Val Leu Ser Val  Pro Gly Pro 
    1130                 1135                 1140             


Glu Gly  Arg Pro Gly Phe Ala  Gly Phe Pro Gly Pro  Ala Gly Pro 
    1145                 1150                 1155             


Lys Gly  Asn Leu Gly Ser Lys  Gly Glu Arg Gly Ser  Pro Gly Pro 
    1160                 1165                 1170             


Lys Gly  Glu Lys Gly Glu Pro  Gly Ser Ile Phe Ser  Pro Asp Gly 
    1175                 1180                 1185             


Gly Ala  Leu Gly Pro Ala Gln  Lys Gly Ala Lys Gly  Glu Pro Gly 
    1190                 1195                 1200             


Phe Arg  Gly Pro Pro Gly Pro  Tyr Gly Arg Pro Gly  Tyr Lys Gly 
    1205                 1210                 1215             


Glu Ile  Gly Phe Pro Gly Arg  Pro Gly Arg Pro Gly  Met Asn Gly 
    1220                 1225                 1230             


Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp Ala Ser  Leu Gly Phe 
    1235                 1240                 1245             


Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser Asn Val  Phe Ala Glu 
    1265                 1270                 1275             


Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro Gly Asn  Gln Gly Pro 
    1280                 1285                 1290             


Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln Leu Glu  Ala Glu Met 
    1310                 1315                 1320             


Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe Gly Ser  Ser Leu Pro 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Tyr Pro  Gly Ile Pro 
    1355                 1360                 1365             


Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln Pro Gly  Pro Pro Gly 
    1370                 1375                 1380             


Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu Gly Arg  Gln Gly Pro 
    1385                 1390                 1395             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Ser Phe  Pro Gly Pro 
    1400                 1405                 1410             


His Arg  Gln Thr Ile Ser Val  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala Ser Ser  Gly Val Arg 
    1430                 1435                 1440             


Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly Gln Val  His Glu Val 
    1445                 1450                 1455             


Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu Gln Glu  Glu Leu Tyr 
    1460                 1465                 1470             


Val Arg  Val Gln Asn Gly Phe  Arg Lys Val Gln Leu  Glu Ala Arg 
    1475                 1480                 1485             


Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu Val Ala  Ala Leu Gln 
    1490                 1495                 1500             


Pro Pro  Val Val Gln Leu His  Asp Ser Asn Pro Tyr  Pro Arg Arg 
    1505                 1510                 1515             


Glu His  Pro His Pro Thr Ala  Arg Pro Trp Arg Ala  Asp Asp Ile 
    1520                 1525                 1530             


Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro Gln Pro  Tyr Pro Gly 
    1535                 1540                 1545             


Ala Pro  His His Ser Ser Tyr  Val His Leu Arg Pro  Ala Arg Pro 
    1550                 1555                 1560             


Thr Ser  Pro Pro Ala His Ser  His Arg Asp Phe Gln  Pro Val Leu 
    1565                 1570                 1575             


His Leu  Val Ala Leu Asn Ser  Pro Leu Ser Gly Gly  Met Arg Gly 
    1580                 1585                 1590             


Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln Gln Ala  Arg Ala Val 
    1595                 1600                 1605             


Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu Ser Ser  Arg Leu Gln 
    1610                 1615                 1620             


Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp Arg Ala  Ala Val Pro 
    1625                 1630                 1635             


Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe Pro Ser  Trp Glu Ala 
    1640                 1645                 1650             


Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys Pro Gly  Ala Arg Ile 
    1655                 1660                 1665             


Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg His Pro  Thr Trp Pro 
    1670                 1675                 1680             


Gln Lys  Ser Val Trp His Gly  Ser Asp Pro Asn Gly  Arg Arg Leu 
    1685                 1690                 1695             


Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr Glu Ala  Pro Ser Ala 
    1700                 1705                 1710             


Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly Arg Leu  Leu Gly Gln 
    1715                 1720                 1725             


Ser Ala  Ala Ser Cys His His  Ala Tyr Ile Val Leu  Cys Ile Glu 
    1730                 1735                 1740             


Asn Ser  Phe Met Thr Ala Ser  Lys 
    1745                 1750     


<210> 253
<211> 1142
<212> PRT
<213> Homo sapiens

<400> 253
Met Arg Leu Thr Gly Pro Trp Lys Leu Trp Leu Trp Met Ser Ile Phe 
1               5                   10                  15      


Leu Leu Pro Ala Ser Thr Ser Val Thr Val Arg Asp Lys Thr Glu Glu 
            20                  25                  30          


Ser Cys Pro Ile Leu Arg Ile Glu Gly His Gln Leu Thr Tyr Asp Asn 
        35                  40                  45              


Ile Asn Lys Leu Glu Val Ser Gly Phe Asp Leu Gly Asp Ser Phe Ser 
    50                  55                  60                  


Leu Arg Arg Ala Phe Cys Glu Ser Asp Lys Thr Cys Phe Lys Leu Gly 
65                  70                  75                  80  


Ser Ala Leu Leu Ile Arg Asp Thr Ile Lys Ile Phe Pro Lys Gly Leu 
                85                  90                  95      


Pro Glu Glu Tyr Ser Val Ala Ala Met Phe Arg Val Arg Arg Asn Ala 
            100                 105                 110         


Lys Lys Glu Arg Trp Phe Leu Trp Gln Val Leu Asn Gln Gln Asn Ile 
        115                 120                 125             


Pro Gln Ile Ser Ile Val Val Asp Gly Gly Lys Lys Val Val Glu Phe 
    130                 135                 140                 


Met Phe Gln Ala Thr Glu Gly Asp Val Leu Asn Tyr Ile Phe Arg Asn 
145                 150                 155                 160 


Arg Glu Leu Arg Pro Leu Phe Asp Arg Gln Trp His Lys Leu Gly Ile 
                165                 170                 175     


Ser Ile Gln Ser Gln Val Ile Ser Leu Tyr Met Asp Cys Asn Leu Ile 
            180                 185                 190         


Ala Arg Arg Gln Thr Asp Glu Lys Asp Thr Val Asp Phe His Gly Arg 
        195                 200                 205             


Thr Val Ile Ala Thr Arg Ala Ser Asp Gly Lys Pro Val Asp Ile Glu 
    210                 215                 220                 


Leu His Gln Leu Lys Ile Tyr Cys Ser Ala Asn Leu Ile Ala Gln Glu 
225                 230                 235                 240 


Thr Cys Cys Glu Ile Ser Asp Thr Lys Cys Pro Glu Gln Asp Gly Phe 
                245                 250                 255     


Gly Asn Ile Ala Ser Ser Trp Val Thr Ala His Ala Ser Lys Met Ser 
            260                 265                 270         


Ser Tyr Leu Pro Ala Lys Gln Glu Leu Lys Asp Gln Cys Gln Cys Ile 
        275                 280                 285             


Pro Asn Lys Gly Glu Ala Gly Leu Pro Gly Ala Pro Gly Ser Pro Gly 
    290                 295                 300                 


Gln Lys Gly His Lys Gly Glu Pro Gly Glu Asn Gly Leu His Gly Ala 
305                 310                 315                 320 


Pro Gly Phe Pro Gly Gln Lys Gly Glu Gln Gly Phe Glu Gly Ser Lys 
                325                 330                 335     


Gly Glu Thr Gly Glu Lys Gly Glu Gln Gly Glu Lys Gly Asp Pro Ala 
            340                 345                 350         


Leu Ala Gly Leu Asn Gly Glu Asn Gly Leu Lys Gly Asp Leu Gly Pro 
        355                 360                 365             


His Gly Pro Pro Gly Pro Lys Gly Glu Lys Gly Asp Thr Gly Pro Pro 
    370                 375                 380                 


Gly Pro Pro Ala Leu Pro Gly Ser Leu Gly Ile Gln Gly Pro Gln Gly 
385                 390                 395                 400 


Pro Pro Gly Lys Glu Gly Gln Arg Gly Arg Arg Gly Lys Thr Gly Pro 
                405                 410                 415     


Pro Gly Lys Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile Gln 
            420                 425                 430         


Gly Ile His Gln Thr Leu Gly Gly Tyr Tyr Asn Lys Asp Asn Lys Gly 
        435                 440                 445             


Asn Asp Glu His Glu Ala Gly Gly Leu Lys Gly Asp Lys Gly Glu Thr 
    450                 455                 460                 


Gly Leu Pro Gly Phe Pro Gly Ser Val Gly Pro Lys Gly Gln Lys Gly 
465                 470                 475                 480 


Glu Pro Gly Glu Pro Phe Thr Lys Gly Glu Lys Gly Asp Arg Gly Glu 
                485                 490                 495     


Pro Gly Val Ile Gly Ser Gln Gly Val Lys Gly Glu Pro Gly Asp Pro 
            500                 505                 510         


Gly Pro Pro Gly Leu Ile Gly Ser Pro Gly Leu Lys Gly Gln Gln Gly 
        515                 520                 525             


Ser Ala Gly Ser Met Gly Pro Arg Gly Pro Pro Gly Asp Val Gly Leu 
    530                 535                 540                 


Pro Gly Glu His Gly Ile Pro Gly Lys Gln Gly Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Gly Asp Pro Gly Gly Ile Ile Gly Pro Pro Gly Leu Pro Gly Pro Lys 
                565                 570                 575     


Gly Glu Ala Gly Pro Pro Gly Lys Ser Leu Pro Gly Glu Pro Gly Leu 
            580                 585                 590         


Asp Gly Asn Pro Gly Ala Pro Gly Pro Arg Gly Pro Lys Gly Glu Arg 
        595                 600                 605             


Gly Leu Pro Gly Val His Gly Ser Pro Gly Asp Ile Gly Pro Gln Gly 
    610                 615                 620                 


Ile Gly Ile Pro Gly Arg Thr Gly Ala Gln Gly Pro Ala Gly Glu Pro 
625                 630                 635                 640 


Gly Ile Gln Gly Pro Arg Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly 
                645                 650                 655     


Thr Pro Gly Asn Asp Gly Val Pro Gly Arg Asp Gly Lys Pro Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Gly Asp Pro Ile Ala Leu Pro Leu Leu Gly Asp Ile 
        675                 680                 685             


Gly Ala Leu Leu Lys Asn Phe Cys Gly Asn Cys Gln Ala Ser Val Pro 
    690                 695                 700                 


Gly Leu Lys Ser Asn Lys Gly Glu Glu Gly Gly Ala Gly Glu Pro Gly 
705                 710                 715                 720 


Lys Tyr Asp Ser Met Ala Arg Lys Gly Asp Ile Gly Pro Arg Gly Pro 
                725                 730                 735     


Pro Gly Ile Pro Gly Arg Glu Gly Pro Lys Gly Ser Lys Gly Glu Arg 
            740                 745                 750         


Gly Tyr Pro Gly Ile Pro Gly Glu Lys Gly Asp Glu Gly Leu Gln Gly 
        755                 760                 765             


Ile Pro Gly Ile Pro Gly Ala Pro Gly Pro Thr Gly Pro Pro Gly Leu 
    770                 775                 780                 


Met Gly Arg Thr Gly His Pro Gly Pro Thr Gly Ala Lys Gly Glu Lys 
785                 790                 795                 800 


Gly Ser Asp Gly Pro Pro Gly Lys Pro Gly Pro Pro Gly Pro Pro Gly 
                805                 810                 815     


Ile Pro Phe Asn Glu Arg Asn Gly Met Ser Ser Leu Tyr Lys Ile Lys 
            820                 825                 830         


Gly Gly Val Asn Val Pro Ser Tyr Pro Gly Pro Pro Gly Pro Pro Gly 
        835                 840                 845             


Pro Lys Gly Asp Pro Gly Pro Val Gly Glu Pro Gly Ala Met Gly Leu 
    850                 855                 860                 


Pro Gly Leu Glu Gly Phe Pro Gly Val Lys Gly Asp Arg Gly Pro Ala 
865                 870                 875                 880 


Gly Pro Pro Gly Ile Ala Gly Met Ser Gly Lys Pro Gly Ala Pro Gly 
                885                 890                 895     


Pro Pro Gly Val Pro Gly Glu Pro Gly Glu Arg Gly Pro Val Gly Asp 
            900                 905                 910         


Ile Gly Phe Pro Gly Pro Glu Gly Pro Ser Gly Lys Pro Gly Ile Asn 
        915                 920                 925             


Gly Lys Asp Gly Ile Pro Gly Ala Gln Gly Ile Met Gly Lys Pro Gly 
    930                 935                 940                 


Asp Arg Gly Pro Lys Gly Glu Arg Gly Asp Gln Gly Ile Pro Gly Asp 
945                 950                 955                 960 


Arg Gly Ser Gln Gly Glu Arg Gly Lys Pro Gly Leu Thr Gly Met Lys 
                965                 970                 975     


Gly Ala Ile Gly Pro Met Gly Pro Pro Gly Asn Lys Gly Ser Met Gly 
            980                 985                 990         


Ser Pro Gly His Gln Gly Pro Pro  Gly Ser Pro Gly Ile  Pro Gly Ile 
        995                 1000                 1005             


Pro Ala  Asp Ala Val Ser Phe  Glu Glu Ile Lys Lys  Tyr Ile Asn 
    1010                 1015                 1020             


Gln Glu  Val Leu Arg Ile Phe  Glu Glu Arg Met Ala  Val Phe Leu 
    1025                 1030                 1035             


Ser Gln  Leu Lys Leu Pro Ala  Ala Met Leu Ala Ala  Gln Ala Tyr 
    1040                 1045                 1050             


Gly Arg  Pro Gly Pro Pro Gly  Lys Asp Gly Leu Pro  Gly Pro Pro 
    1055                 1060                 1065             


Gly Asp  Pro Gly Pro Gln Gly  Tyr Arg Gly Gln Lys  Gly Glu Arg 
    1070                 1075                 1080             


Gly Glu  Pro Gly Ile Gly Leu  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1085                 1090                 1095             


Thr Ser  Ala Leu Gly Leu Pro  Gly Ser Pro Gly Ala  Pro Gly Pro 
    1100                 1105                 1110             


Gln Gly  Pro Pro Gly Pro Ser  Gly Arg Cys Asn Pro  Glu Asp Cys 
    1115                 1120                 1125             


Leu Tyr  Pro Val Ser His Ala  His Gln Arg Thr Gly  Gly Asn 
    1130                 1135                 1140         


<210> 254
<211> 1125
<212> PRT
<213> Homo sapiens

<400> 254
Met Trp Asn Arg Tyr Phe Val Phe Tyr Leu Leu Leu Leu Ser Ala Phe 
1               5                   10                  15      


Thr Ser Gln Thr Val Ser Gly Gln Arg Lys Lys Gly Pro Lys Ser Asn 
            20                  25                  30          


Leu Leu Ala Arg Lys Ser Asp Val Gln Gly Ser Ile Cys Phe Ile Asp 
        35                  40                  45              


Ile Val Phe Ile Val Asp Ser Ser Glu Ser Ser Lys Ile Ala Leu Phe 
    50                  55                  60                  


Asp Lys Gln Lys Asp Phe Val Asp Ser Leu Ser Asp Lys Ile Phe Gln 
65                  70                  75                  80  


Leu Thr Pro Gly Arg Ser Leu Glu Tyr Asp Ile Lys Leu Ala Ala Leu 
                85                  90                  95      


Gln Phe Ser Ser Ser Val Gln Ile Asp Pro Pro Phe Ser Ser Trp Lys 
            100                 105                 110         


Asp Leu Gln Thr Phe Lys Gln Lys Val Lys Ser Met Asn Leu Ile Gly 
        115                 120                 125             


Gln Gly Thr Phe Ser Tyr Tyr Ala Ile Ser Asn Ala Thr Arg Leu Leu 
    130                 135                 140                 


Lys Arg Glu Gly Arg Lys Asp Gly Val Lys Val Val Leu Leu Met Thr 
145                 150                 155                 160 


Asp Gly Ile Asp His Pro Lys Asn Pro Asp Val Gln Ser Ile Ser Glu 
                165                 170                 175     


Asp Ala Arg Ile Ser Gly Ile Ser Phe Ile Thr Ile Ala Leu Ser Thr 
            180                 185                 190         


Val Val Asn Glu Ala Lys Leu Arg Leu Ile Ser Gly Asp Ser Ser Ser 
        195                 200                 205             


Glu Pro Thr Leu Leu Leu Ser Asp Pro Thr Leu Val Asp Lys Ile Gln 
    210                 215                 220                 


Asp Arg Leu Asp Ile Leu Phe Glu Lys Lys Cys Glu Arg Lys Ile Cys 
225                 230                 235                 240 


Glu Cys Glu Lys Gly Asp Pro Gly Asp Pro Gly Pro Pro Gly Thr His 
                245                 250                 255     


Gly Asn Pro Gly Ile Lys Gly Glu Arg Gly Pro Lys Gly Asn Pro Gly 
            260                 265                 270         


Asn Ala Gln Lys Gly Glu Ala Gly Glu Arg Gly Pro Gly Gly Ile Pro 
        275                 280                 285             


Gly Tyr Lys Gly Asp Lys Gly Glu Arg Gly Glu Cys Gly Lys Pro Gly 
    290                 295                 300                 


Ile Lys Gly Asp Lys Gly Ser Pro Gly Pro Tyr Gly Pro Lys Gly Pro 
305                 310                 315                 320 


Arg Gly Ile Gln Gly Ile Thr Gly Pro Pro Gly Asp Pro Gly Pro Lys 
                325                 330                 335     


Gly Phe Gln Gly Asn Lys Gly Glu Pro Gly Pro Pro Gly Pro Tyr Gly 
            340                 345                 350         


Ser Pro Gly Ala Pro Gly Ile Gly Gln Gln Gly Ile Lys Gly Glu Arg 
        355                 360                 365             


Gly Gln Glu Gly Arg Pro Gly Ala Pro Gly Pro Ile Gly Val Gly Glu 
    370                 375                 380                 


Pro Gly Gln Pro Gly Pro Arg Gly Pro Glu Gly Val Pro Gly Glu Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Gly Phe Pro Gly Pro Lys Gly Glu Lys Gly Ser 
                405                 410                 415     


Glu Gly Pro Thr Gly Pro Gln Gly Leu Gln Gly Leu Ser Ile Lys Gly 
            420                 425                 430         


Glu Lys Gly Asp Ile Gly Pro Val Gly Pro Gln Gly Pro Met Gly Ile 
        435                 440                 445             


Pro Gly Ile Gly Ser Gln Gly Glu Gln Gly Ile Gln Gly Pro Ile Gly 
    450                 455                 460                 


Pro Pro Gly Pro Gln Gly Pro Ala Gly Gln Gly Leu Pro Gly Ser Lys 
465                 470                 475                 480 


Gly Glu Val Gly Gln Met Gly Pro Thr Gly Pro Arg Gly Pro Val Gly 
                485                 490                 495     


Ile Gly Val Gln Gly Pro Lys Gly Glu Pro Gly Ser Ile Gly Leu Pro 
            500                 505                 510         


Gly Gln Pro Gly Val Pro Gly Glu Asp Gly Ala Ala Gly Lys Lys Gly 
        515                 520                 525             


Glu Ala Gly Leu Pro Gly Ala Arg Gly Pro Glu Gly Pro Pro Gly Lys 
    530                 535                 540                 


Gly Gln Pro Gly Pro Lys Gly Asp Glu Gly Lys Lys Gly Ser Lys Gly 
545                 550                 555                 560 


Asn Gln Gly Gln Arg Gly Leu Pro Gly Pro Glu Gly Pro Lys Gly Glu 
                565                 570                 575     


Pro Gly Ile Met Gly Pro Phe Gly Met Pro Gly Thr Ser Ile Pro Gly 
            580                 585                 590         


Pro Pro Gly Pro Lys Gly Asp Arg Gly Gly Pro Gly Ile Pro Gly Phe 
        595                 600                 605             


Lys Gly Glu Pro Gly Leu Ser Ile Arg Gly Pro Lys Gly Val Gln Gly 
    610                 615                 620                 


Pro Arg Gly Pro Val Gly Ala Pro Gly Leu Lys Gly Asp Gly Tyr Pro 
625                 630                 635                 640 


Gly Val Pro Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Met Gly 
                645                 650                 655     


Leu Arg Gly Val Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Val Arg 
            660                 665                 670         


Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Val Gly Thr Gln Gly Pro 
        675                 680                 685             


Lys Gly Asp Thr Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro 
    690                 695                 700                 


Gly Tyr Gly Ser Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe 
705                 710                 715                 720 


Pro Gly Pro Lys Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly 
                725                 730                 735     


Glu His Gly Glu Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu 
            740                 745                 750         


Ile Gly Glu Pro Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys 
        755                 760                 765             


Gly Asp Leu Gly Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu 
    770                 775                 780                 


Ile Cys Gly Cys Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val 
785                 790                 795                 800 


Phe Val Ile Asp Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile 
                805                 810                 815     


Ile Lys Asn Phe Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu 
            820                 825                 830         


Ala Thr Ala Arg Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys 
        835                 840                 845             


Val Ala Asn Leu Lys Gln Phe Ser Ser Lys Asp Asp Phe Lys Leu Ala 
    850                 855                 860                 


Val Asp Asn Met Gln Tyr Leu Gly Glu Gly Thr Tyr Thr Ala Thr Ala 
865                 870                 875                 880 


Leu Gln Ala Ala Asn Asp Met Phe Glu Asp Ala Arg Pro Gly Val Lys 
                885                 890                 895     


Lys Val Ala Leu Val Ile Thr Asp Gly Gln Thr Asp Ser Arg Asp Lys 
            900                 905                 910         


Glu Lys Leu Thr Glu Val Val Lys Asn Ala Ser Asp Thr Asn Val Glu 
        915                 920                 925             


Ile Phe Val Ile Gly Val Val Lys Lys Asn Asp Pro Asn Phe Glu Ile 
    930                 935                 940                 


Phe His Lys Glu Met Asn Leu Ile Ala Thr Asp Pro Glu His Val Tyr 
945                 950                 955                 960 


Gln Phe Asp Asp Phe Phe Thr Leu Gln Asp Thr Leu Lys Gln Lys Leu 
                965                 970                 975     


Phe Gln Lys Ile Cys Glu Asp Phe Asp Ser Tyr Leu Val Gln Ile Phe 
            980                 985                 990         


Gly Ser Ser Ser Pro Gln Pro Gly  Phe Gly Met Ser Gly  Glu Glu Leu 
        995                 1000                 1005             


Ser Glu  Ser Thr Pro Glu Pro  Gln Lys Glu Ile Ser  Glu Ser Leu 
    1010                 1015                 1020             


Ser Val  Thr Arg Asp Gln Asp  Glu Asp Asp Lys Ala  Pro Glu Pro 
    1025                 1030                 1035             


Thr Trp  Ala Asp Asp Leu Pro  Ala Thr Thr Ser Ser  Glu Ala Thr 
    1040                 1045                 1050             


Thr Thr  Pro Arg Pro Leu Leu  Ser Thr Pro Val Asp  Gly Ala Glu 
    1055                 1060                 1065             


Asp Pro  Arg Cys Leu Glu Ala  Leu Lys Pro Gly Asn  Cys Gly Glu 
    1070                 1075                 1080             


Tyr Val  Val Arg Trp Tyr Tyr  Asp Lys Gln Val Asn  Ser Cys Ala 
    1085                 1090                 1095             


Arg Phe  Trp Phe Ser Gly Cys  Asn Gly Ser Gly Asn  Arg Phe Asn 
    1100                 1105                 1110             


Ser Glu  Lys Glu Cys Gln Glu  Thr Cys Ile Gln Gly  
    1115                 1120                 1125 


<210> 255
<211> 519
<212> PRT
<213> Homo sapiens

<400> 255
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Leu Leu Phe Gln Ile His Lys 
        515                 


<210> 256
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 256
Asn Pro Gly Pro 
1               


<210> 257
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(30) 
<223> /note="This sequence may encompass 1-10 'ccg'
      repeating units"

<400> 257
ccgccgccgc cgccgccgcc gccgccgccg                                        30


<210> 258
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(24) 
<223> /note="This sequence may encompass 2-8 'ccg'
      repeating units"

<400> 258
ccgccgccgc cgccgccgcc gccg                                              24


<210> 259
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(18) 
<223> /note="This sequence may encompass 3-6 'ccg'
      repeating units"

<400> 259
ccgccgccgc cgccgccg                                                     18


<210> 260
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(15) 
<223> /note="This sequence may encompass 4-5 'ccg'
      repeating units"

<400> 260
ccgccgccgc cgccg                                                        15


<210> 261
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(15) 
<223> /note="This sequence may encompass 1-5 'ccg'
      repeating units"

<400> 261
ccgccgccgc cgccg                                                        15


<210> 262
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 262
ccgccgccgc cg                                                           12


<210> 263
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 263
ccgccgccgc cgccg                                                        15


<210> 264
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(30) 
<223> /note="This sequence may encompass 1-10 'gcc'
      repeating units"

<400> 264
gccgccgccg ccgccgccgc cgccgccgcc                                        30


<210> 265
<211> 150
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(150) 
<223> /note="This sequence may encompass 50-150 nucleotides"

<400> 265
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       150


<210> 266
<211> 150
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(150) 
<223> /note="This sequence may encompass 75-150 nucleotides"

<400> 266
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       150


<210> 267
<211> 150
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(150) 
<223> /note="This sequence may encompass 85-150 nucleotides"

<400> 267
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       150


<210> 268
<211> 150
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(150) 
<223> /note="This sequence may encompass 90-150 nucleotides"

<400> 268
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       150


<210> 269
<211> 120
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(120) 
<223> /note="This sequence may encompass 90-120 nucleotides"

<400> 269
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


<210> 270
<211> 130
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(130) 
<223> /note="This sequence may encompass 90-130 nucleotides"

<400> 270
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa                                                             130


<210> 271
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 271
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      120


<210> 272
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 272
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210> 273
<211> 120
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 273
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


