                         SEQUENCE LISTING

<110>  Moss, Marcia
 
<120>  METHODS AND COMPOSITIONS FOR INHIBITING ADAM8 BIOLOGICAL 
       ACTIVITIES

<130>  722-02-PCT

<150>  62/845,544
<151>  2019-05-09

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  2
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  3
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(149)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Xaa Arg Leu Pro Gly Pro Xaa Val Xaa Xaa Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Xaa Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Xaa Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Gly Thr Xaa Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  4
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  4

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Ala Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  5
<211>  180
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  5

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Lys Val Arg Lys Leu Pro Ser 
            20                  25                  30          


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
        35                  40                  45              


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
    50                  55                  60                  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
65                  70                  75                  80  


Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val Glu 
                85                  90                  95      


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu Arg 
            100                 105                 110         


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
        115                 120                 125             


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
    130                 135                 140                 


Leu Gln Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly Ser 
145                 150                 155                 160 


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
                165                 170                 175     


Ser Leu Pro Ser 
            180 


<210>  6
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Lys Val Lys Lys Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  7
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Lys Val Lys Lys Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Ala Ala Ala His 
    130                 135                 140                 


Leu Leu Ala Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  8
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Lys Val Lys Lys Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Asn Ala Asn His 
    130                 135                 140                 


Leu Leu Asn Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  9
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Ala Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Asn Ala Asn His 
    130                 135                 140                 


Leu Leu Asn Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  10
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide

<400>  10

Gly Ser Cys Gly Ser 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Ser Gly Ser Cys 
1               5   


<210>  12
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Leu Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  13
<211>  824
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Xaa Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  14
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  14

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  15
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  15

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Gly Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  16
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  16

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Cys Leu Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  17
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  17

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Trp Arg Leu Pro Gly Pro Lys Val Arg Lys Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Ser Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Ser Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Ser Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  18
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Xaa Arg Leu Pro Gly Pro Xaa Val Xaa Xaa Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Xaa Xaa Asn Xaa Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Xaa Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Xaa Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    130                 135                 140                 


Leu Leu Gln Thr Ala Gly Thr Xaa Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  19
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(149)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Xaa Arg Leu Pro Gly Pro Xaa Val Xaa Xaa Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Phe Thr Leu His Leu Xaa Xaa Asn Xaa Asp Leu Leu 
    50                  55                  60                  


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Thr Glu Gln Pro Arg Gly Gln Asp His Xaa Phe Tyr Gln Gly His Val 
                85                  90                  95      


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Xaa Ala Gly Leu 
            100                 105                 110         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        115                 120                 125             


Asp Glu Gly Gly Glu Gly Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Gly Thr Xaa Gly Val Ser Asp Asp Ser Leu Gly 
145                 150                 155                 160 


Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly 
                165                 170                 175     


Asp Ser Leu Pro Ser 
            180     


<210>  20
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (138)..(150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Met Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val 
1               5                   10                  15      


Val Leu Pro Xaa Arg Leu Pro Gly Pro Xaa Val Xaa Xaa Ala Leu Pro 
            20                  25                  30          


Ser His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        35                  40                  45              


Thr Gly His Asn Xaa Phe Thr Leu His Leu Xaa Xaa Asn Xaa Asp Leu 
    50                  55                  60                  


Leu Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Xaa Gly Ser Glu 
65                  70                  75                  80  


Val Thr Glu Gln Pro Arg Gly Gln Asp His Xaa Phe Tyr Gln Gly His 
                85                  90                  95      


Val Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Xaa Ala Gly 
            100                 105                 110         


Leu Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro 
        115                 120                 125             


Leu Asp Glu Gly Gly Glu Gly Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr Xaa Gly Val Ser Asp Asp Ser Leu 
145                 150                 155                 160 


Gly Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro 
                165                 170                 175     


Gly Asp Ser Leu Pro Ser 
            180         


<210>  21
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  21
atgattgccc ccagccggcc ctgggccctc atggagcagt atgaggtcgt gttgccgcgg       60

cgtctgccag gcccccgagt ccgccgagct ctgccctccc acttgggcct gcacccagag      120

agggtgagct acgtccttgg ggccacaggg cacaacttca ccctccacct gcggaagaac      180

agggacctgc tgggttccgg ctacacagag acctatacgg ctgccaatgg ctccgaggtg      240

acggagcagc ctcgcgggca ggaccactgc ttataccagg gccacgtaga ggggtacccg      300

gactcagccg ccagcctcag cacctgtgcc ggcctcaggg gtttcttcca ggtggggtca      360

gacctgcacc tgatcgagcc cctggatgaa ggtggcgagg gcggacggca cgccgtgtac      420

caggctgagc acctgctgca gacggccggg acctgcgggg tcagcgacga cagcctgggc      480

agcctcctgg gaccccggac ggcagccgtc ttcaggcctc ggcccgggga ctctctgcca      540

tccggatctg gatctcatca tcatcatcat cattaa                                576


<210>  22
<211>  576
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  22
atgattgccc ccagccggcc ctgggccctc atggagcagt atgaggtcgt gttgccgcgg       60

cgtctgccag gcccccgagt ccgcgctgct ctgccctccc acttgggcct gcacccagag      120

agggtgagct acgtccttgg ggccacaggg cacaacttca ccctccacct gcggaagaac      180

agggacctgc tgggttccgg ctacacagag acctatacgg ctgccaatgg ctccgaggtg      240

acggagcagc ctcgcgggca ggaccactct ttctaccagg gccacgtaga ggggtacccg      300

gactcagccg ccagcctcag cacctctgcc ggcctcaggg gtttcttcca ggtggggtca      360

gacctgcacc tgatcgagcc cctggatgaa ggtggcgagg gcggacggca cgccgtgtac      420

caggctgagc acctgctgca gacggccggg acctctgggg tcagcgacga cagcctgggc      480

agcctcctgg gaccccggac ggcagccgtc ttcaggcctc ggcccgggga ctctctgcca      540

tccggatctg gatctcatca tcatcatcat cattaa                                576


<210>  23
<211>  591
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  23

Ala Thr Gly Gly Gly Cys Thr Cys Gly Thr Gly Thr Gly Gly Cys Thr 
1               5                   10                  15      


Cys Cys Ala Thr Thr Gly Cys Gly Cys Cys Gly Ala Gly Cys Cys Gly 
            20                  25                  30          


Thr Cys Cys Gly Thr Gly Gly Gly Cys Gly Cys Thr Gly Ala Thr Gly 
        35                  40                  45              


Gly Ala Ala Cys Ala Gly Thr Ala Thr Gly Ala Ala Gly Thr Gly Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ala Cys Cys Ala Thr Gly Gly Cys Gly Gly Cys Thr 
65                  70                  75                  80  


Gly Cys Cys Cys Gly Gly Thr Cys Cys Gly Ala Ala Ala Gly Thr Gly 
                85                  90                  95      


Cys Gly Cys Ala Ala Ala Gly Cys Gly Cys Thr Gly Cys Cys Gly Thr 
            100                 105                 110         


Cys Gly Cys Ala Thr Cys Thr Gly Gly Gly Thr Cys Thr Gly Cys Ala 
        115                 120                 125             


Cys Cys Cys Thr Gly Ala Gly Cys Gly Thr Gly Thr Gly Ala Gly Cys 
    130                 135                 140                 


Thr Ala Thr Gly Thr Gly Cys Thr Gly Gly Gly Cys Gly Cys Gly Ala 
145                 150                 155                 160 


Cys Cys Gly Gly Cys Cys Ala Thr Ala Ala Cys Thr Thr Cys Ala Cys 
                165                 170                 175     


Ala Thr Thr Gly Cys Ala Thr Cys Thr Thr Cys Gly Thr Ala Ala Ala 
            180                 185                 190         


Ala Ala Thr Cys Gly Thr Gly Ala Thr Thr Thr Ala Cys Thr Gly Gly 
        195                 200                 205             


Gly Cys Thr Cys Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Gly Ala 
    210                 215                 220                 


Ala Ala Cys Cys Thr Ala Thr Ala Cys Gly Gly Cys Cys Gly Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Gly Gly Thr Ala Gly Cys Gly Ala Ala Gly Thr Gly Ala 
                245                 250                 255     


Cys Cys Gly Ala Ala Cys Ala Gly Cys Cys Gly Cys Gly Thr Gly Gly 
            260                 265                 270         


Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr Ala Gly Cys Thr Thr Thr 
        275                 280                 285             


Thr Ala Cys Cys Ala Gly Gly Gly Cys Cys Ala Thr Gly Thr Gly Gly 
    290                 295                 300                 


Ala Ala Gly Gly Gly Thr Ala Thr Cys Cys Thr Gly Ala Thr Ala Gly 
305                 310                 315                 320 


Cys Gly Cys Gly Gly Cys Ala Ala Gly Cys Cys Thr Gly Ala Gly Cys 
                325                 330                 335     


Ala Cys Ala Thr Cys Gly Gly Cys Thr Gly Gly Cys Cys Thr Gly Cys 
            340                 345                 350         


Gly Gly Gly Gly Cys Thr Thr Thr Thr Thr Thr Cys Ala Gly Gly Thr 
        355                 360                 365             


Gly Gly Gly Ala Ala Gly Cys Gly Ala Cys Thr Thr Gly Cys Ala Cys 
    370                 375                 380                 


Cys Thr Gly Ala Thr Thr Gly Ala Ala Cys Cys Gly Cys Thr Gly Gly 
385                 390                 395                 400 


Ala Thr Gly Ala Ala Gly Gly Cys Gly Gly Cys Gly Ala Ala Gly Gly 
                405                 410                 415     


Thr Gly Gly Gly Cys Gly Thr Cys Ala Thr Gly Cys Gly Gly Thr Gly 
            420                 425                 430         


Thr Ala Thr Cys Ala Gly Gly Cys Gly Gly Ala Ala Cys Ala Thr Cys 
        435                 440                 445             


Thr Gly Thr Thr Gly Cys Ala Gly Ala Cys Ala Gly Cys Gly Gly Gly 
    450                 455                 460                 


Cys Ala Cys Ala Ala Gly Cys Gly Gly Cys Gly Thr Cys Ala Gly Cys 
465                 470                 475                 480 


Gly Ala Cys Gly Ala Thr Thr Cys Cys Cys Thr Thr Gly Gly Cys Ala 
                485                 490                 495     


Gly Cys Cys Thr Thr Cys Thr Gly Gly Gly Ala Cys Cys Ala Cys Gly 
            500                 505                 510         


Thr Ala Cys Cys Gly Cys Gly Gly Cys Ala Gly Thr Thr Thr Thr Thr 
        515                 520                 525             


Cys Gly Thr Cys Cys Gly Cys Gly Thr Cys Cys Gly Gly Gly Cys Gly 
    530                 535                 540                 


Ala Cys Ala Gly Cys Cys Thr Gly Cys Cys Thr Ala Gly Cys Gly Gly 
545                 550                 555                 560 


Cys Thr Cys Thr Gly Gly Gly Ala Gly Cys Cys Ala Thr Cys Ala Cys 
                565                 570                 575     


Cys Ala Cys Cys Ala Thr Cys Ala Thr Cys Ala Cys Thr Ala Ala 
            580                 585                 590     


<210>  24
<211>  576
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  24
atgatagcgc caagccgtcc ctgggcgctg atggaacagt atgaagtggt gctgccgtgg       60

cgtctgccag gtccacgtgt gcgtcgtgcg ttgccgtctc atctgggcct gcaccctgaa      120

cgtgtgagct atgtgttagg cgcgaccggc cataatttca ccctgcatct tcgtaaaaat      180

cgtgatctgc tgggcagcgg ctataccgag acctacacag cggccaatgg cagcgaagtg      240

accgaacagc cgcgtggcca agatcattgc ttttatcagg gccatgtgga aggatacccg      300

gattcagcgg cgagcctgag cacttgcgcc ggtttacggg gcttttttca ggtggggagc      360

gatttgcatc tgattgaacc gctggatgaa ggaggggagg gaggccgcca tgcggtgtat      420

caagcggagc atcttttaca aaccgcggga acctgcggcg tgagcgatga cagcctgggg      480

tctttgttgg gaccacgtac cgcagcggtc tttcgtccgc gtccgggcga tagcttaccg      540

tccggctcgg ggtcccatca tcaccaccat cattga                                576


<210>  25
<211>  579
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  25
atgatcgcgc cgtctcgtcc gtgggcgctg atggaacagt atgaagtggt gctgccccgt       60

cgtctgccgg gtccccgtgt gcgtggcgcc ctgccgagcc atctgggcct gcatccggaa      120

cgtgtgagct atgtgctggg tgcgaccggc cacaatttta ccctgcacct gcgtaaaaat      180

cgtgatctgc tgggctcagg atataccgaa acctatacag cggccaacgg ctcagaggtg      240

accgaacagc cgcgtggcca ggaccatagc ttctatcagg gccatgtgga aggttacccc      300

gactcagcag cgagcctgag cacaagcgcg ggattgcgtg gattttttca ggtgggcagc      360

gatctgcatc tgattgaacc gctggatgaa gggggcgaag gaggccgtca tgcggtgtat      420

caggcggaac acttgctgca gaccgcgggt acctctggcg tcagcgatga cagcctgggt      480

agcctgttgg gaccgcgtac cgcggcagta tttcgtccgc gtccgggcga tagccttccg      540

agcggtagct gcggctccca tcatcaccac catcattaa                             579


<210>  26
<211>  576
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  26
atgattgccc cgagccgtcc gtgggcgctg atggaacagt atgaagtggt gctgccgcgt       60

cgtctgccgg gaccgcgtgt gcgtcgtgcg ctgccgagcc atctgggcct gcatccggaa      120

cgtgtgagct atgtgcttgg cgcgaccggc cataatttca cgttgcatct gcgtaaaaat      180

cgtgatctgc tgggcagcgg ctataccgaa acctacacag ctgccaatgg cagcgaagtg      240

accgaacagc cgcgtggcca ggatcattgc ttttatcagg gccatgtgga ggggtatcca      300

gatagtgccg cgagcctgag cacctgtgcg ggcttgcgtg gcttttttca ggtggggagc      360

gatctgcatc ttattgaacc gctggatgaa gggggcgaag gtggccgtca tgccgtgtat      420

caagcggaac atttactgca gaccgcgggt acctgcggcg tgagcgatga ttccctgggt      480

agcctgttgg ggcctcgtac cgctgcggtg tttcgtccgc gtccgggcga tagtctgcct      540

agcggtagcg ggtcgcatca tcaccaccat cactaa                                576


<210>  27
<211>  540
<212>  DNA
<213>  homo sapiens

<400>  27
attgccccca gccggccctg ggccctcatg gagcagtatg aggtcgtgtt gccgtggcgt       60

ctgccaggcc cccgagtccg ccgagctctg ccctcccact tgggcctgca cccagagagg      120

gtgagctacg tccttggggc cacagggcac aacttcaccc tccacctgcg gaagaacagg      180

gacctgctgg gctccggcta cacagagacc tatacggctg ccaatggctc cgaggtgacg      240

gagcagcctc gcgggcagga ccactgcttc taccagggcc acgtagaggg gtacccggac      300

tcagccgcca gcctcagcac ctgtgccggc ctcaggggtt tcttccaggt ggggtcagac      360

ctgcacctga tcgagcccct ggatgaaggt ggcgagggcg gacggcacgc cgtgtaccag      420

gctgagcacc tgctgcagac ggccgggacc tgcggggtca gcgacgacag cctgggcagc      480

ctcctgggac cccggacggc agccgtcttc aggcctcggc ccggggactc tctgccatcc      540


