                         SEQUENCE LISTING

<110>  ACADEMIA SINICA
 
<120>  LAMA2, PLXDC2 AND MLL4 AS NOVEL BIOMARKERS FOR PREDIABETES AND 
       DIABETES

<130>  10011-060PCT

<150>  62849118
<151>  2019-05-16

<150>  62849118
<151>  2019-05-16

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  2715
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ala Ala Gly Gly Gly Ser Cys Pro Gly Pro Gly Ser Ala 
1               5                   10                  15      


Arg Gly Arg Phe Pro Gly Arg Pro Arg Gly Ala Gly Gly Gly Gly Gly 
            20                  25                  30          


Arg Gly Gly Arg Gly Asn Gly Ala Glu Arg Val Arg Val Ala Leu Arg 
        35                  40                  45              


Arg Gly Gly Gly Ala Thr Gly Pro Gly Gly Ala Glu Pro Gly Glu Asp 
    50                  55                  60                  


Thr Ala Leu Leu Arg Leu Leu Gly Leu Arg Arg Gly Leu Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Leu Trp Ala Gly Pro Arg Val Gln Arg Gly Arg Gly Arg Gly 
                85                  90                  95      


Arg Gly Arg Gly Trp Gly Pro Ser Arg Gly Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ser Ser Asp Gly Glu Ser Asp Glu Glu Glu Phe Gln Gly Phe His Ser 
        115                 120                 125             


Asp Glu Asp Val Ala Pro Ser Ser Leu Arg Ser Ala Leu Arg Ser Gln 
    130                 135                 140                 


Arg Gly Arg Ala Pro Arg Gly Arg Gly Arg Lys His Lys Thr Thr Pro 
145                 150                 155                 160 


Leu Pro Pro Pro Arg Leu Ala Asp Val Ala Pro Thr Pro Pro Lys Thr 
                165                 170                 175     


Pro Ala Arg Lys Arg Gly Glu Glu Gly Thr Glu Arg Met Val Gln Ala 
            180                 185                 190         


Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln Ala Pro Arg Ser 
        195                 200                 205             


Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg Gly Arg Pro Pro 
    210                 215                 220                 


Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln Ala Val Val Val 
225                 230                 235                 240 


Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro Pro Pro Pro Val 
                245                 250                 255     


Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys Lys Glu Gly Pro 
            260                 265                 270         


Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln Ser Ser Arg Gly 
        275                 280                 285             


Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly Leu Pro Phe Val 
    290                 295                 300                 


Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met Gly Gln Leu Ser 
305                 310                 315                 320 


Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His Glu Glu Ser Trp 
                325                 330                 335     


Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln Gly Gly Ser Pro 
            340                 345                 350         


Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu Glu Glu Glu Lys 
        355                 360                 365             


Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu Lys Glu Glu Arg 
    370                 375                 380                 


Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys Glu Glu Ala Lys 
385                 390                 395                 400 


Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser Pro Pro Pro Pro 
                405                 410                 415     


Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu Cys Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro Pro Pro Pro Pro 
        435                 440                 445             


Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val Val Pro Ala Thr 
    450                 455                 460                 


Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro Ser Gln Arg Ala 
465                 470                 475                 480 


Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr Ser Pro Pro Thr 
                485                 490                 495     


Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu Asp Ser Pro Thr 
            500                 505                 510         


Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile Arg Gln Phe Ile 
        515                 520                 525             


Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile Lys Thr Pro Arg 
    530                 535                 540                 


Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys Val Glu Val Ser 
545                 550                 555                 560 


Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro Val Pro Gln Glu 
                565                 570                 575     


Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr Pro Pro Ser Thr 
            580                 585                 590         


Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu Arg Glu Pro Thr 
        595                 600                 605             


Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro Pro Pro Pro Ala 
    610                 615                 620                 


Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala Pro Ala Thr Ser 
625                 630                 635                 640 


Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe Thr Pro Ser Glu 
                645                 650                 655     


Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro Pro Pro Leu Gly 
            660                 665                 670         


Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala Asp Asp Ser Pro 
        675                 680                 685             


Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn His Leu Ser Leu 
    690                 695                 700                 


Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys Ala Glu Val Ser 
705                 710                 715                 720 


Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln Thr Gln Ala Gln 
                725                 730                 735     


Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu Leu Pro Gln Ala 
            740                 745                 750         


Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro Ser Pro Gln Gln 
        755                 760                 765             


Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val Gly Ser Leu Pro 
    770                 775                 780                 


Leu Ser Gly Val Glu Glu Lys Met Phe Ser Leu Leu Lys Arg Ala Lys 
785                 790                 795                 800 


Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln Lys Val Ala Ala 
                805                 810                 815     


Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu Val Ala Gly Ala 
            820                 825                 830         


Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser Glu Asp Glu Ser 
        835                 840                 845             


Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu Ser Pro Val Gln 
    850                 855                 860                 


Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala Val Ala Leu Gly 
865                 870                 875                 880 


Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg Leu Ser Ala Leu 
                885                 890                 895     


Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp Thr Ser Ser Ala 
            900                 905                 910         


Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg Gly Lys Val Glu 
        915                 920                 925             


Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly Ser Gly Gly Thr 
    930                 935                 940                 


Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His His Gly Lys Lys 
945                 950                 955                 960 


Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys Leu Arg Val Gln 
                965                 970                 975     


Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro Lys Phe Gly Gly 
            980                 985                 990         


Pro Asn Thr Lys Lys Gln Cys Cys  Val Tyr Arg Lys Cys  Asp Lys Ile 
        995                 1000                 1005             


Glu Ala  Arg Lys Met Glu Arg  Leu Ala Lys Lys Gly  Arg Thr Ile 
    1010                 1015                 1020             


Val Lys  Thr Leu Leu Pro Trp  Asp Ser Asp Glu Ser  Pro Glu Ala 
    1025                 1030                 1035             


Ser Pro  Gly Pro Pro Gly Pro  Arg Arg Gly Ala Gly  Ala Gly Gly 
    1040                 1045                 1050             


Pro Arg  Glu Glu Val Val Ala  His Pro Gly Pro Glu  Glu Gln Asp 
    1055                 1060                 1065             


Ser Leu  Leu Gln Arg Lys Ser  Ala Arg Arg Cys Val  Lys Gln Arg 
    1070                 1075                 1080             


Pro Ser  Tyr Asp Ile Phe Glu  Asp Ser Asp Asp Ser  Glu Pro Gly 
    1085                 1090                 1095             


Gly Pro  Pro Ala Pro Arg Arg  Arg Thr Pro Arg Glu  Asn Glu Leu 
    1100                 1105                 1110             


Pro Leu  Pro Glu Pro Glu Glu  Gln Ser Arg Pro Arg  Lys Pro Thr 
    1115                 1120                 1125             


Leu Gln  Pro Val Leu Gln Leu  Lys Ala Arg Arg Arg  Leu Asp Lys 
    1130                 1135                 1140             


Asp Ala  Leu Ala Pro Gly Pro  Phe Ala Ser Phe Pro  Asn Gly Trp 
    1145                 1150                 1155             


Thr Gly  Lys Gln Lys Ser Pro  Asp Gly Val His Arg  Val Arg Val 
    1160                 1165                 1170             


Asp Phe  Lys Glu Asp Cys Asp  Leu Glu Asn Val Trp  Leu Met Gly 
    1175                 1180                 1185             


Gly Leu  Ser Val Leu Thr Ser  Val Pro Gly Gly Pro  Pro Met Val 
    1190                 1195                 1200             


Cys Leu  Leu Cys Ala Ser Lys  Gly Leu His Glu Leu  Val Phe Cys 
    1205                 1210                 1215             


Gln Val  Cys Cys Asp Pro Phe  His Pro Phe Cys Leu  Glu Glu Ala 
    1220                 1225                 1230             


Glu Arg  Pro Leu Pro Gln His  His Asp Thr Trp Cys  Cys Arg Arg 
    1235                 1240                 1245             


Cys Lys  Phe Cys His Val Cys  Gly Arg Lys Gly Arg  Gly Ser Lys 
    1250                 1255                 1260             


His Leu  Leu Glu Cys Glu Arg  Cys Arg His Ala Tyr  His Pro Ala 
    1265                 1270                 1275             


Cys Leu  Gly Pro Ser Tyr Pro  Thr Arg Ala Thr Arg  Lys Arg Arg 
    1280                 1285                 1290             


His Trp  Ile Cys Ser Ala Cys  Val Arg Cys Lys Ser  Cys Gly Ala 
    1295                 1300                 1305             


Thr Pro  Gly Lys Asn Trp Asp  Val Glu Trp Ser Gly  Asp Tyr Ser 
    1310                 1315                 1320             


Leu Cys  Pro Arg Cys Thr Gln  Leu Tyr Glu Lys Gly  Asn Tyr Cys 
    1325                 1330                 1335             


Pro Ile  Cys Thr Arg Cys Tyr  Glu Asp Asn Asp Tyr  Glu Ser Lys 
    1340                 1345                 1350             


Met Met  Gln Cys Ala Gln Cys  Asp His Trp Val His  Ala Lys Cys 
    1355                 1360                 1365             


Glu Gly  Leu Ser Asp Glu Asp  Tyr Glu Ile Leu Ser  Gly Leu Pro 
    1370                 1375                 1380             


Asp Ser  Val Leu Tyr Thr Cys  Gly Pro Cys Ala Gly  Ala Ala Gln 
    1385                 1390                 1395             


Pro Arg  Trp Arg Glu Ala Leu  Ser Gly Ala Leu Gln  Gly Gly Leu 
    1400                 1405                 1410             


Arg Gln  Val Leu Gln Gly Leu  Leu Ser Ser Lys Val  Val Gly Pro 
    1415                 1420                 1425             


Leu Leu  Leu Cys Thr Gln Cys  Gly Pro Asp Gly Lys  Gln Leu His 
    1430                 1435                 1440             


Pro Gly  Pro Cys Gly Leu Gln  Ala Val Ser Gln Arg  Phe Glu Asp 
    1445                 1450                 1455             


Gly His  Tyr Lys Ser Val His  Ser Phe Met Glu Asp  Met Val Gly 
    1460                 1465                 1470             


Ile Leu  Met Arg His Ser Glu  Glu Gly Glu Thr Pro  Asp Arg Arg 
    1475                 1480                 1485             


Ala Gly  Gly Gln Met Lys Gly  Leu Leu Leu Lys Leu  Leu Glu Ser 
    1490                 1495                 1500             


Ala Phe  Gly Trp Phe Asp Ala  His Asp Pro Lys Tyr  Trp Arg Arg 
    1505                 1510                 1515             


Ser Thr  Arg Leu Pro Asn Gly  Val Leu Pro Asn Ala  Val Leu Pro 
    1520                 1525                 1530             


Pro Ser  Leu Asp His Val Tyr  Ala Gln Trp Arg Gln  Gln Glu Pro 
    1535                 1540                 1545             


Glu Thr  Pro Glu Ser Gly Gln  Pro Pro Gly Asp Pro  Ser Ala Ala 
    1550                 1555                 1560             


Phe Gln  Gly Lys Asp Pro Ala  Ala Phe Ser His Leu  Glu Asp Pro 
    1565                 1570                 1575             


Arg Gln  Cys Ala Leu Cys Leu  Lys Tyr Gly Asp Ala  Asp Ser Lys 
    1580                 1585                 1590             


Glu Ala  Gly Arg Leu Leu Tyr  Ile Gly Gln Asn Glu  Trp Thr His 
    1595                 1600                 1605             


Val Asn  Cys Ala Ile Trp Ser  Ala Glu Val Phe Glu  Glu Asn Asp 
    1610                 1615                 1620             


Gly Ser  Leu Lys Asn Val His  Ala Ala Val Ala Arg  Gly Arg Gln 
    1625                 1630                 1635             


Met Arg  Cys Glu Leu Cys Leu  Lys Pro Gly Ala Thr  Val Gly Cys 
    1640                 1645                 1650             


Cys Leu  Ser Ser Cys Leu Ser  Asn Phe His Phe Met  Cys Ala Arg 
    1655                 1660                 1665             


Ala Ser  Tyr Cys Ile Phe Gln  Asp Asp Lys Lys Val  Phe Cys Gln 
    1670                 1675                 1680             


Lys His  Thr Asp Leu Leu Asp  Gly Lys Glu Ile Val  Asn Pro Asp 
    1685                 1690                 1695             


Gly Phe  Asp Val Leu Arg Arg  Val Tyr Val Asp Phe  Glu Gly Ile 
    1700                 1705                 1710             


Asn Phe  Lys Arg Lys Phe Leu  Thr Gly Leu Glu Pro  Asp Ala Ile 
    1715                 1720                 1725             


Asn Val  Leu Ile Gly Ser Ile  Arg Ile Asp Ser Leu  Gly Thr Leu 
    1730                 1735                 1740             


Ser Asp  Leu Ser Asp Cys Glu  Gly Arg Leu Phe Pro  Ile Gly Tyr 
    1745                 1750                 1755             


Gln Cys  Ser Arg Leu Tyr Trp  Ser Thr Val Asp Ala  Arg Arg Arg 
    1760                 1765                 1770             


Cys Trp  Tyr Arg Cys Arg Ile  Leu Glu Tyr Arg Pro  Trp Gly Pro 
    1775                 1780                 1785             


Arg Glu  Glu Pro Ala His Leu  Glu Ala Ala Glu Glu  Asn Gln Thr 
    1790                 1795                 1800             


Ile Val  His Ser Pro Ala Pro  Ser Ser Glu Pro Pro  Gly Gly Glu 
    1805                 1810                 1815             


Asp Pro  Pro Leu Asp Thr Asp  Val Leu Val Pro Gly  Ala Pro Glu 
    1820                 1825                 1830             


Arg His  Ser Pro Ile Gln Asn  Leu Asp Pro Pro Leu  Arg Pro Asp 
    1835                 1840                 1845             


Ser Gly  Ser Ala Pro Pro Pro  Ala Pro Arg Ser Phe  Ser Gly Ala 
    1850                 1855                 1860             


Arg Ile  Lys Val Pro Asn Tyr  Ser Pro Ser Arg Arg  Pro Leu Gly 
    1865                 1870                 1875             


Gly Val  Ser Phe Gly Pro Leu  Pro Ser Pro Gly Ser  Pro Ser Ser 
    1880                 1885                 1890             


Leu Thr  His His Ile Pro Thr  Val Gly Asp Pro Asp  Phe Pro Ala 
    1895                 1900                 1905             


Pro Pro  Arg Arg Ser Arg Arg  Pro Ser Pro Leu Ala  Pro Arg Pro 
    1910                 1915                 1920             


Pro Pro  Ser Arg Trp Ala Ser  Pro Pro Leu Lys Thr  Ser Pro Gln 
    1925                 1930                 1935             


Leu Arg  Val Pro Pro Pro Thr  Ser Val Val Thr Ala  Leu Thr Pro 
    1940                 1945                 1950             


Thr Ser  Gly Glu Leu Ala Pro  Pro Gly Pro Ala Pro  Ser Pro Pro 
    1955                 1960                 1965             


Pro Pro  Glu Asp Leu Gly Pro  Asp Phe Glu Asp Met  Glu Val Val 
    1970                 1975                 1980             


Ser Gly  Leu Ser Ala Ala Asp  Leu Asp Phe Ala Ala  Ser Leu Leu 
    1985                 1990                 1995             


Gly Thr  Glu Pro Phe Gln Glu  Glu Ile Val Ala Ala  Gly Ala Met 
    2000                 2005                 2010             


Gly Ser  Ser His Gly Gly Pro  Gly Asp Ser Ser Glu  Glu Glu Ser 
    2015                 2020                 2025             


Ser Pro  Thr Ser Arg Tyr Ile  His Phe Pro Val Thr  Val Val Ser 
    2030                 2035                 2040             


Ala Pro  Gly Leu Ala Pro Ser  Ala Thr Pro Gly Ala  Pro Arg Ile 
    2045                 2050                 2055             


Glu Gln  Leu Asp Gly Val Asp  Asp Gly Thr Asp Ser  Glu Ala Glu 
    2060                 2065                 2070             


Ala Val  Gln Gln Pro Arg Gly  Gln Gly Thr Pro Pro  Ser Gly Pro 
    2075                 2080                 2085             


Gly Val  Val Arg Ala Gly Val  Leu Gly Ala Ala Gly  Asp Arg Ala 
    2090                 2095                 2100             


Arg Pro  Pro Glu Asp Leu Pro  Ser Glu Ile Val Asp  Phe Val Leu 
    2105                 2110                 2115             


Lys Asn  Leu Gly Gly Pro Gly  Asp Gly Gly Ala Gly  Pro Arg Glu 
    2120                 2125                 2130             


Glu Ser  Leu Pro Pro Ala Pro  Pro Leu Ala Asn Gly  Ser Gln Pro 
    2135                 2140                 2145             


Ser Gln  Gly Leu Thr Ala Ser  Pro Ala Asp Pro Thr  Arg Thr Phe 
    2150                 2155                 2160             


Ala Trp  Leu Pro Gly Ala Pro  Gly Val Arg Val Leu  Ser Leu Gly 
    2165                 2170                 2175             


Pro Ala  Pro Glu Pro Pro Lys  Pro Ala Thr Ser Lys  Ile Ile Leu 
    2180                 2185                 2190             


Val Asn  Lys Leu Gly Gln Val  Phe Val Lys Met Ala  Gly Glu Gly 
    2195                 2200                 2205             


Glu Pro  Val Pro Pro Pro Val  Lys Gln Pro Pro Leu  Pro Pro Thr 
    2210                 2215                 2220             


Ile Ser  Pro Thr Ala Pro Thr  Ser Trp Thr Leu Pro  Pro Gly Pro 
    2225                 2230                 2235             


Leu Leu  Gly Val Leu Pro Val  Val Gly Val Val Arg  Pro Ala Pro 
    2240                 2245                 2250             


Pro Pro  Pro Pro Pro Pro Leu  Thr Leu Val Leu Ser  Ser Gly Pro 
    2255                 2260                 2265             


Ala Ser  Pro Pro Arg Gln Ala  Ile Arg Val Lys Arg  Val Ser Thr 
    2270                 2275                 2280             


Phe Ser  Gly Arg Ser Pro Pro  Ala Pro Pro Pro Tyr  Lys Ala Pro 
    2285                 2290                 2295             


Arg Leu  Asp Glu Asp Gly Glu  Ala Ser Glu Asp Thr  Pro Gln Val 
    2300                 2305                 2310             


Pro Gly  Leu Gly Ser Gly Gly  Phe Ser Arg Val Arg  Met Lys Thr 
    2315                 2320                 2325             


Pro Thr  Val Arg Gly Val Leu  Asp Leu Asp Arg Pro  Gly Glu Pro 
    2330                 2335                 2340             


Ala Gly  Glu Glu Ser Pro Gly  Pro Leu Gln Glu Arg  Ser Pro Leu 
    2345                 2350                 2355             


Leu Pro  Leu Pro Glu Asp Gly  Pro Pro Gln Val Pro  Asp Gly Pro 
    2360                 2365                 2370             


Pro Asp  Leu Leu Leu Glu Ser  Gln Trp His His Tyr  Ser Gly Glu 
    2375                 2380                 2385             


Ala Ser  Ser Ser Glu Glu Glu  Pro Pro Ser Pro Asp  Asp Lys Glu 
    2390                 2395                 2400             


Asn Gln  Ala Pro Lys Arg Thr  Gly Pro His Leu Arg  Phe Glu Ile 
    2405                 2410                 2415             


Ser Ser  Glu Asp Gly Phe Ser  Val Glu Ala Glu Ser  Leu Glu Gly 
    2420                 2425                 2430             


Ala Trp  Arg Thr Leu Ile Glu  Lys Val Gln Glu Ala  Arg Gly His 
    2435                 2440                 2445             


Ala Arg  Leu Arg His Leu Ser  Phe Ser Gly Met Ser  Gly Ala Arg 
    2450                 2455                 2460             


Leu Leu  Gly Ile His His Asp  Ala Val Ile Phe Leu  Ala Glu Gln 
    2465                 2470                 2475             


Leu Pro  Gly Ala Gln Arg Cys  Gln His Tyr Lys Phe  Arg Tyr His 
    2480                 2485                 2490             


Gln Gln  Gly Glu Gly Gln Glu  Glu Pro Pro Leu Asn  Pro His Gly 
    2495                 2500                 2505             


Ala Ala  Arg Ala Glu Val Tyr  Leu Arg Lys Cys Thr  Phe Asp Met 
    2510                 2515                 2520             


Phe Asn  Phe Leu Ala Ser Gln  His Arg Val Leu Pro  Glu Gly Ala 
    2525                 2530                 2535             


Thr Cys  Asp Glu Glu Glu Asp  Glu Val Gln Leu Arg  Ser Thr Arg 
    2540                 2545                 2550             


Arg Ala  Thr Ser Leu Glu Leu  Pro Met Ala Met Arg  Phe Arg His 
    2555                 2560                 2565             


Leu Lys  Lys Thr Ser Lys Glu  Ala Val Gly Val Tyr  Arg Ser Ala 
    2570                 2575                 2580             


Ile His  Gly Arg Gly Leu Phe  Cys Lys Arg Asn Ile  Asp Ala Gly 
    2585                 2590                 2595             


Glu Met  Val Ile Glu Tyr Ser  Gly Ile Val Ile Arg  Ser Val Leu 
    2600                 2605                 2610             


Thr Asp  Lys Arg Glu Lys Phe  Tyr Asp Gly Lys Gly  Ile Gly Cys 
    2615                 2620                 2625             


Tyr Met  Phe Arg Met Asp Asp  Phe Asp Val Val Asp  Ala Thr Met 
    2630                 2635                 2640             


His Gly  Asn Ala Ala Arg Phe  Ile Asn His Ser Cys  Glu Pro Asn 
    2645                 2650                 2655             


Cys Phe  Ser Arg Val Ile His  Val Glu Gly Gln Lys  His Ile Val 
    2660                 2665                 2670             


Ile Phe  Ala Leu Arg Arg Ile  Leu Arg Gly Glu Glu  Leu Thr Tyr 
    2675                 2680                 2685             


Asp Tyr  Lys Phe Pro Ile Glu  Asp Ala Ser Asn Lys  Leu Pro Cys 
    2690                 2695                 2700             


Asn Cys  Gly Ala Lys Arg Cys  Arg Arg Phe Leu Asn  
    2705                 2710                 2715 


<210>  2
<211>  3122
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Ala Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210>  3
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu 
1               5                   10                  15      


Leu Cys His Phe Phe Thr Asp Gln Phe Gln Phe Ala Asp Gly Lys Pro 
            20                  25                  30          


Gly Asp Gln Ile Leu Asp Trp Gln Tyr Gly Val Thr Gln Ala Phe Pro 
        35                  40                  45              


His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg 
    50                  55                  60                  


Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala 
65                  70                  75                  80  


Ser Val Gly Gln Asp Ser Pro Glu Pro Arg Ser Phe Thr Asp Leu Leu 
                85                  90                  95      


Leu Asp Asp Gly Gln Asp Asn Asn Thr Gln Ile Glu Arg Val Asn Leu 
            100                 105                 110         


Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu Ile Thr Val 
        115                 120                 125             


Ala Thr Gly Gly Phe Ile Tyr Thr Gly Glu Val Val His Arg Met Leu 
    130                 135                 140                 


Thr Ala Thr Gln Tyr Ile Ala Pro Leu Met Ala Asn Phe Asp Pro Ser 
145                 150                 155                 160 


Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala Leu 
                165                 170                 175     


Val Val Gln Trp Asp His Val His Leu Gln Asp Asn Tyr Asn Leu Gly 
            180                 185                 190         


Ser Phe Thr Phe Gln Ala Thr Leu Leu Met Asp Gly Arg Ile Ile Phe 
        195                 200                 205             


Gly Tyr Lys Glu Ile Pro Val Leu Val Thr Gln Ile Ser Ser Thr Asn 
    210                 215                 220                 


His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His Arg 
225                 230                 235                 240 


Ile Gln Gln Ile Pro Asn Val Arg Arg Arg Thr Ile Tyr Glu Tyr His 
                245                 250                 255     


Arg Val Glu Leu Gln Met Ser Lys Ile Thr Asn Ile Ser Ala Val Glu 
            260                 265                 270         


Met Thr Pro Leu Pro Thr Cys Leu Gln Phe Asn Arg Cys Gly Pro Cys 
        275                 280                 285             


Val Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu Gln 
    290                 295                 300                 


Arg Cys Ser Ser Gly Phe Asp Arg His Arg Gln Asp Trp Val Asp Ser 
305                 310                 315                 320 


Gly Cys Pro Glu Glu Ser Lys Glu Lys Met Cys Glu Asn Thr Glu Pro 
                325                 330                 335     


Val Glu Thr Ser Ser Arg Thr Thr Thr Thr Val Gly Ala Thr Thr Thr 
            340                 345                 350         


Gln Phe Arg Val Leu Thr Thr Thr Arg Arg Ala Val Thr Ser Gln Phe 
        355                 360                 365             


Pro Thr Ser Leu Pro Thr Glu Asp Asp Thr Lys Ile Ala Leu His Leu 
    370                 375                 380                 


Lys Asp Asn Gly Ala Ser Thr Asp Asp Ser Ala Ala Glu Lys Lys Gly 
385                 390                 395                 400 


Gly Thr Leu His Ala Gly Leu Ile Ile Gly Ile Leu Ile Leu Val Leu 
                405                 410                 415     


Ile Val Ala Thr Ala Ile Leu Val Thr Val Tyr Met Tyr His His Pro 
            420                 425                 430         


Thr Ser Ala Ala Ser Ile Phe Phe Ile Glu Arg Arg Pro Ser Arg Trp 
        435                 440                 445             


Pro Ala Met Lys Phe Arg Arg Gly Ser Gly His Pro Ala Tyr Ala Glu 
    450                 455                 460                 


Val Glu Pro Val Gly Glu Lys Glu Gly Phe Ile Val Ser Glu Gln Cys 
465                 470                 475                 480 


