                         SEQUENCE LISTING

<110>  Valneva SE
 
<120>  A SUBUNIT VACCINE FOR TREATMENT OR PREVENTION OF A RESPIRATORY 
       TRACT INFECTION

<130>  EP19175413.4

<140>  PAT040/PCT
<141>  2020-05-15

<150>  EP/19175413.4
<151>  2019-05-20

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  1

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Thr Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Asn 
    530                 535                 


<210>  2
<211>  84
<212>  PRT
<213>  Human metapneumovirus

<400>  2

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu 
            20                  25                  30          


Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro 
65                  70                  75                  80  


Arg Gln Ser Arg 
                


<210>  3
<211>  437
<212>  PRT
<213>  Human metapneumovirus

<400>  3

Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala Ala Ala Val 
1               5                   10                  15      


Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val 
            20                  25                  30          


Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala Val Ser Thr 
        35                  40                  45              


Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg Glu Leu Lys 
    50                  55                  60                  


Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys Asn Lys Cys 
65                  70                  75                  80  


Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg 
                85                  90                  95      


Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr 
            100                 105                 110         


Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala 
        115                 120                 125             


Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu 
    130                 135                 140                 


Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu Ile Gly Val 
145                 150                 155                 160 


Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val 
                165                 170                 175     


Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Gly 
            180                 185                 190         


Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr 
        195                 200                 205             


Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys 
    210                 215                 220                 


Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala Gly Ile Asn 
225                 230                 235                 240 


Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn 
                245                 250                 255     


Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser Met Val Ala 
            260                 265                 270         


Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys 
        275                 280                 285             


Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly 
    290                 295                 300                 


Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn 
305                 310                 315                 320 


Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His Val Ile Lys 
                325                 330                 335     


Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp 
            340                 345                 350         


Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser 
        355                 360                 365             


Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser Ala Glu Lys 
    370                 375                 380                 


Gly Asn Thr Gly Phe Ile Ile Val Ile Ile Leu Ile Ala Val Leu Gly 
385                 390                 395                 400 


Ser Thr Met Ile Leu Val Ser Val Phe Ile Ile Ile Lys Lys Thr Lys 
                405                 410                 415     


Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser Gly Val Thr Asn Asn Gly 
            420                 425                 430         


Phe Ile Pro His Asn 
        435         


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial

<400>  4

Cys Gly Ala Gly Ala 
1               5   


<210>  5
<211>  523
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  5

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gln Pro Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala 
            100                 105                 110         


Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn 
        115                 120                 125             


Ala Leu Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val 
    130                 135                 140                 


Arg Val Leu Ala Thr Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu 
                165                 170                 175     


Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val 
            180                 185                 190         


Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu 
        195                 200                 205             


Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro 
    210                 215                 220                 


Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val 
225                 230                 235                 240 


Arg Arg Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val 
                245                 250                 255     


Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys 
            260                 265                 270         


Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr 
        275                 280                 285             


Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly 
    290                 295                 300                 


Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp 
305                 310                 315                 320 


His Val Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser 
                325                 330                 335     


Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val 
            340                 345                 350         


Ser Thr Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly 
        355                 360                 365             


Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn 
    370                 375                 380                 


Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr 
385                 390                 395                 400 


Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu 
                405                 410                 415     


Ser Lys Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser 
            420                 425                 430         


Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala 
        435                 440                 445             


Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp 
    450                 455                 460                 


Gln Ser Asn Arg Ile Leu Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg 
465                 470                 475                 480 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                485                 490                 495     


Thr Phe Leu Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            500                 505                 510         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        515                 520             


<210>  6
<211>  529
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  6

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gln Pro Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala 
            100                 105                 110         


Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn 
        115                 120                 125             


Ala Leu Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val 
    130                 135                 140                 


Arg Val Leu Ala Phe Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Arg Ala Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu 
                165                 170                 175     


Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val 
            180                 185                 190         


Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu 
        195                 200                 205             


Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro 
    210                 215                 220                 


Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val 
225                 230                 235                 240 


Arg Arg Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val 
                245                 250                 255     


Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys 
            260                 265                 270         


Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr 
        275                 280                 285             


Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly 
    290                 295                 300                 


Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp 
305                 310                 315                 320 


His Val Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser 
                325                 330                 335     


Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val 
            340                 345                 350         


Ser Thr Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly 
        355                 360                 365             


Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn 
    370                 375                 380                 


Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr 
385                 390                 395                 400 


Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu 
                405                 410                 415     


Ser Lys Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser 
            420                 425                 430         


Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala 
        435                 440                 445             


Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp 
    450                 455                 460                 


Gln Ser Asn Arg Ile Leu Ser Ser Ala Glu Ser Ala Ile Gly Gly Tyr 
465                 470                 475                 480 


Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly 
                485                 490                 495     


Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly Leu Val Pro Arg Gly 
            500                 505                 510         


Ser His His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu 
        515                 520                 525             


Lys 
    


<210>  7
<211>  523
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  7

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Met Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Leu Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gln Pro Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala 
            100                 105                 110         


Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn 
        115                 120                 125             


Ala Leu Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val 
    130                 135                 140                 


Arg Val Leu Ala Thr Met Val Arg Glu Leu Lys Asp Phe Val Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu 
                165                 170                 175     


Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val 
            180                 185                 190         


Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu 
        195                 200                 205             


Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro 
    210                 215                 220                 


Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val 
225                 230                 235                 240 


Arg Arg Lys Gly Phe Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val 
                245                 250                 255     


Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys 
            260                 265                 270         


Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr 
        275                 280                 285             


Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly 
    290                 295                 300                 


Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp 
305                 310                 315                 320 


His Val Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser 
                325                 330                 335     


Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val 
            340                 345                 350         


Ser Thr Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly 
        355                 360                 365             


Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn 
    370                 375                 380                 


Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr 
385                 390                 395                 400 


Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu 
                405                 410                 415     


Ser Lys Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser 
            420                 425                 430         


Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala 
        435                 440                 445             


Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp 
    450                 455                 460                 


Gln Ser Asn Arg Ile Leu Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg 
465                 470                 475                 480 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                485                 490                 495     


Thr Phe Leu Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            500                 505                 510         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        515                 520             


<210>  8
<211>  523
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  8

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Met Leu Cys Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Leu Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gln Pro Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala 
            100                 105                 110         


Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn 
        115                 120                 125             


Ala Leu Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val 
    130                 135                 140                 


Arg Val Leu Ala Thr Met Val Arg Glu Leu Cys Asp Phe Val Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu 
                165                 170                 175     


Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val 
            180                 185                 190         


Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu 
        195                 200                 205             


Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro 
    210                 215                 220                 


Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val 
225                 230                 235                 240 


Arg Arg Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Asp Val 
                245                 250                 255     


Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys 
            260                 265                 270         


Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr 
        275                 280                 285             


Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly 
    290                 295                 300                 


Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp 
305                 310                 315                 320 


His Val Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser 
                325                 330                 335     


Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val 
            340                 345                 350         


Ser Thr Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly 
        355                 360                 365             


Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn 
    370                 375                 380                 


Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr 
385                 390                 395                 400 


Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu 
                405                 410                 415     


Ser Lys Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser 
            420                 425                 430         


Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala 
        435                 440                 445             


Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp 
    450                 455                 460                 


Gln Ser Asn Arg Cys Cys Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg 
465                 470                 475                 480 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                485                 490                 495     


Thr Phe Leu Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            500                 505                 510         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        515                 520             


<210>  9
<211>  529
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  9

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Met Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gln Pro Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala 
            100                 105                 110         


Ile Ala Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Trp Lys Asn 
        115                 120                 125             


Ala Leu Lys Lys Thr Asn Glu Val Val Ser Thr Leu Gly Asn Gly Val 
    130                 135                 140                 


Arg Val Leu Val Thr Met Val Arg Glu Leu Lys Asp Phe Val Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Arg Ala Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu 
                165                 170                 175     


Lys Met Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val 
            180                 185                 190         


Val Arg Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu 
        195                 200                 205             


Asp Leu Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro 
    210                 215                 220                 


Thr Ser Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val 
225                 230                 235                 240 


Arg Arg Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val 
                245                 250                 255     


Ile Tyr Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys 
            260                 265                 270         


Trp Ile Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr 
        275                 280                 285             


Ala Cys Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly 
    290                 295                 300                 


Ser Thr Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp 
305                 310                 315                 320 


His Val Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser 
                325                 330                 335     


Lys Glu Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val 
            340                 345                 350         


Ser Thr Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly 
        355                 360                 365             


Ala Leu Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn 
    370                 375                 380                 


Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr 
385                 390                 395                 400 


Asn Gln Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu 
                405                 410                 415     


Ser Lys Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser 
            420                 425                 430         


Ser Ser Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala 
        435                 440                 445             


Leu Asp Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp 
    450                 455                 460                 


Gln Ser Asn Arg Ile Leu Ser Ser Ala Glu Ser Ala Ile Gly Gly Tyr 
465                 470                 475                 480 


Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly 
                485                 490                 495     


Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly Leu Val Pro Arg Gly 
            500                 505                 510         


Ser His His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu 
        515                 520                 525             


Lys 
    


<210>  10
<211>  27
<212>  PRT
<213>  T4 bacteriophage

<400>  10

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  11
<211>  8
<212>  PRT
<213>  Artificiial

<400>  11

Gly Ser His His His His His His 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  12

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  13
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  13

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Thr Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  14
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  14

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  15
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  15

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Ser Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Pro Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ala Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Arg Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  16
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  16

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Gln Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Arg Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asn Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Trp Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Val Ile 
                485                 490                 495     


Leu Val Ala Val Leu Gly Leu Thr Met Ile Ser Val Ser Ile Ile Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Arg Lys Pro Thr Gly Ala Pro Pro Glu Leu Asn 
        515                 520                 525             


Gly Val Thr Asn Gly Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  17
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  17

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Thr Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Asn 
    530                 535                 


<210>  18
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  18

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Lys Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Leu Thr Met Ile Ser Val Ser Ile Ile Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Arg Lys Pro Thr Gly Ala Pro Pro Glu Leu Asn 
        515                 520                 525             


Gly Val Thr Asn Gly Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  19
<211>  1590
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  19
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcaccctg gaagtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgat caagaccgag ctggacctga ccaagtctgc cctgagagaa      240

ctgaggaccg tgtctgccga tcagctggcc agagaggaac agatcgagca gcctagacag      300

tccggatgtg gtgctggtgc tacagctggc gtggccattg ccaagaccat ccggctggaa      360

tctgaagtga ccgccatcaa gaacgccctg aaaaagacca acgaggccgt gtctaccctc      420

ggcaatggcg ttagagtgct ggcctttgct gtgcgcgagc tgaaggactt cgtgtccaag      480

aacctgacca gggctctgaa caagaacaag tgtgatatcg ccgacctgaa gatggccgtg      540

tcctttagcc agttcaaccg gcggttcctg aacgtcgtgc ggcagttctc tgataacgcc      600

ggcatcaccc ctgccatcag cctggatctg atgaccgatg ccgagctggc tagagccgtg      660

tccaacatgc ctacctctgc cggccagatc aagctgatgc tggaaaacag agccatggtc      720

cgacggaaag gcttcggctt tctgatcggc gtgtacggct cctccgtgat ctacatggtg      780

cagctgccta tcttcggcgt gatcgacacc ccttgctgga tcgtgaaggc cgctcctagc      840

tgctctgaga agaagggcaa ctacgcctgc ctgctgagag aggaccaagg ctggtactgt      900

cagaacgccg gctccaccgt gtactacccc aacgagaagg actgcgagac aagaggcgac      960

cacgtgttct gcgatacctg cgctggcatc aatgtggccg agcagtccaa agagtgcaac     1020

atcaacatct ccaccaccaa ctatccctgc aaggtgtcca ccggcaggca ccctatttcc     1080

atggtggctc tgtctccact gggcgccctg gtggcttgtt ataagggcgt gtcctgctcc     1140

atcggctcca acagagtggg catcatcaag cagctgaaca agggctgcag ctacatcacc     1200

aaccaggacg ccgataccgt gaccatcgac aataccgtgt atcagctgtc caaggtggaa     1260

ggcgagcagc acgtgatcaa gggcagacct gtgtcctcca gcttcgaccc cgtgaagttc     1320

cctgaggatc agttcaacgt ggccctggac caggtgttcg agtccatcga gaactctcag     1380

gctctggtgg accagtccaa ccggatcctg tcctctgccg agtctgctat cggcggctat     1440

atccccgagg ctcctagaga tggccaggcc tatgttcgga aggatggcga atgggtgctg     1500

ctgtctacct tcctcggagg cctggtgcct agaggctctc accaccatca tcaccactcc     1560

gcttggtccc atccacagtt cgagaagtga                                      1590


<210>  20
<211>  1572
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  20
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcaccctg gaagtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgat caagaccgag ctggacctga ccaagtctgc cctgagagaa      240

ctgaggaccg tgtctgccga tcagctggcc agagaggaac agatcgagca gcctagacag      300

tccggatgtg gtgctggtgc tacagctggc gtggccattg ccaagaccat ccggctggaa      360

tctgaagtga ccgccatcaa gaacgccctg aaaaagacca acgaggccgt gtctaccctc      420

ggcaatggcg ttagagtgct ggccacagcc gtgcgcgagc tgaaggattt cgtgtccaag      480

aacctgacca gggccatcaa caagaacaag tgtgatatcg ccgacctgaa gatggccgtg      540

tccttcagcc agttcaaccg gcggttcctg aatgtcgtgc ggcagttctc tgacaacgcc      600

ggcatcaccc ctgccatcag cctggatctg atgaccgatg ccgagctggc tagagccgtg      660

tccaacatgc ctacctctgc cggccagatc aagctgatgc tggaaaacag agccatggtc      720

cgacggaaag gcttcggctt tctgatcggc gtgtacggct cctccgtgat ctacatggtg      780

cagctgccta tcttcggcgt gatcgacacc ccttgctgga tcgtgaaggc cgctcctagc      840

tgctctgaga agaagggcaa ctacgcctgc ctgctgagag aggaccaagg ctggtactgt      900

cagaacgccg gctccaccgt gtactacccc aacgagaagg actgcgagac aagaggcgac      960

cacgtgttct gcgatacctg cgctggcatc aatgtggccg agcagtccaa agagtgcaac     1020

atcaacatct ccaccaccaa ctatccctgc aaggtgtcca ccggcaggca ccctatttcc     1080

atggtggctc tgtctccact gggcgccctg gtggcttgtt ataagggcgt gtcctgctcc     1140

atcggctcca acagagtggg catcatcaag cagctgaaca agggctgcag ctacatcacc     1200

aaccaggacg ccgataccgt gaccatcgac aataccgtgt atcagctgtc caaggtggaa     1260

ggcgagcagc acgtgatcaa gggcagacct gtgtcctcca gcttcgaccc cgtgaagttc     1320

cctgaggatc agttcaacgt ggccctggac caggtgttcg agtccatcga gaactctcag     1380

gctctggtgg accagtccaa ccggattctg tctgccggct acatccccga ggctcctaga     1440

gatggacagg cctacgtcag aaaggacggc gaatgggtgc tgctgtctac ctttctcgga     1500

ggcctggtgc ctagaggctc tcaccaccat catcaccact ccgcttggtc ccatccacag     1560

ttcgagaagt ga                                                         1572


<210>  21
<211>  1572
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  21
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcatgctg gaagtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgct gaaaacagag ctggacctga ccaagagcgc cctgagaaat      240

ctgaggaccg tgtctgccga tcagctggcc agagaggaac agatcgagca gcctagacag      300

tccggatgtg gtgctggtgc tacagctggc gtggccattg ccaagaccat ccggctggaa      360

tctgaagtga ccgccatcaa gaatgccctg aaaaagacca acgaggccgt gtctaccctc      420

ggcaatggcg ttagagtgct ggccacaatg gtccgagagc tgaaggactt cgtgtccaag      480

aacctgacca gggccatcaa caagaacaag tgtgatatcg ccgacctgaa gatggccgtg      540

tcctttagcc agttcaaccg gcggttcctg aacgtcgtgc ggcagttctc tgataacgcc      600

ggcatcaccc ctgccatcag cctggatctg atgaccgatg ccgagctggc tagagccgtg      660

tccaacatgc ctacctctgc cggccagatc aagctgatgc tcgagaacag agctatggtc      720

cgacggaaag gcttcggcat cctgatcggc gtgtacggct cctccgtgat ctacatggtg      780

cagctgccta tcttcggcgt gatcgacacc ccttgctgga tcgtgaaggc cgctcctagc      840

tgctctgaga agaagggcaa ctacgcctgc ctgctgagag aggaccaagg ctggtactgt      900

cagaacgccg gctccaccgt gtactacccc aacgagaagg actgcgagac aagaggcgac      960

cacgtgttct gcgatacctg cgctggcatc aatgtggccg agcagtccaa agagtgcaac     1020

atcaacatct ccaccaccaa ctatccctgc aaggtgtcca ccggcaggca ccctatttcc     1080

atggtggctc tgtctccact gggcgccctg gtggcttgtt ataagggcgt gtcctgctcc     1140

atcggctcca acagagtggg catcatcaag cagctgaaca agggctgcag ctacatcacc     1200

aaccaggacg ccgataccgt gaccatcgac aataccgtgt atcagctgtc caaggtggaa     1260

ggcgagcagc acgtgatcaa gggcagacct gtgtcctcca gcttcgaccc cgtgaagttc     1320

cctgaggatc agttcaacgt ggccctggac caggtgttcg agtccatcga gaactctcag     1380

gctctggtgg accagtccaa ccggattctg tctgccggct acatccccga ggctcctaga     1440

gatggacagg cctacgtcag aaaggacggc gaatgggtgc tgctgtctac ctttctcgga     1500

ggcctggtgc ctagaggctc tcaccaccat catcaccact ccgcttggtc ccatcctcag     1560

ttcgagaagt ga                                                         1572


<210>  22
<211>  1572
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  22
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcatgctg tgtgtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgct gaaaacagag ctggacctga ccaagagcgc cctgagagaa      240

ctgaggaccg tgtctgcaga tcagctggcc agagaggaac agatcgagca gcctagacag      300

tccggatgtg gtgctggtgc tacagctggc gtggccattg ccaagaccat ccggctggaa      360

tctgaagtga ccgccatcaa gaatgccctg aaaaagacca acgaggccgt gtctaccctc      420

ggcaatggcg ttagagtgct ggccacaatg gtccgagagc tgtgcgactt cgtgtccaag      480

aatctgaccc gggccatcaa caagaacaag tgtgatatcg ccgacctgaa gatggccgtg      540

tccttcagcc agttcaaccg gcggttcctg aatgtcgtgc ggcagttctc tgacaacgcc      600

ggcatcaccc ctgccatcag cctggatctg atgaccgatg ccgagctggc tagagccgtg      660

tccaacatgc ctacctctgc cggccagatc aagctgatgc tcgagaacag agctatggtc      720

cgacggaaag gcttcggctt cctgatcggc gtgtacggct ctgacgtgat ctacatggtg      780

cagctgccta tcttcggcgt gatcgacacc ccttgctgga tcgtgaaggc cgctcctagc      840

tgctctgaga agaagggcaa ctacgcctgc ctgctgagag aggaccaagg ctggtactgt      900

cagaacgccg gctccaccgt gtactacccc aacgagaagg actgcgagac aagaggcgac      960

cacgtgttct gcgatacctg cgctggcatc aatgtggccg agcagtccaa agagtgcaac     1020

atcaacatct ccaccaccaa ctatccctgc aaggtgtcca ccggcagaca ccccatttcc     1080

atggtggctc tgtctccact gggtgccctg gtggcttgtt ataagggcgt gtcctgctcc     1140

atcggctcca acagagtggg catcatcaag cagctgaaca agggctgcag ctacatcacc     1200

aaccaggacg ccgataccgt gaccatcgac aataccgtgt atcagctgtc caaggtggaa     1260

ggcgagcagc acgtgatcaa gggcagacct gtgtcctcca gcttcgaccc cgtgaagttc     1320

cctgaggatc agttcaacgt ggccctggac caggtgttcg agtccatcga gaactctcag     1380

gctctggtgg accagtccaa cagatgctgt tccgccggct acatccccga ggctcctaga     1440

gatggacagg cctacgtcag aaaggacggc gaatgggtgc tgctgtctac ctttctcgga     1500

ggcctggtgc ctagaggctc tcaccaccat catcaccact ccgcttggtc ccatccacag     1560

ttcgagaagt ga                                                         1572


<210>  23
<211>  1590
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  23
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcatgctg gaagtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgat caagaccgag ctggacctga ccaagtctgc cctgagagaa      240

ctgaggaccg tgtctgccga tcagctggcc agagaggaac agatcgagca gcctagacag      300

tccggatgtg gtgctggtgc tacagctggc gtggccattg ccaagaccat ccggctggaa      360

tctgaagtga ccgcctggaa gaacgccctg aaaaagacca acgaggtggt gtctaccctc      420

ggcaacggcg tcagagtgct ggtcacaatg gtccgagagc tgaaggactt cgtgtccaag      480

aacctgacca gggctctgaa caagaacaag tgtgatatcg ccgacctgaa gatggccgtg      540

tctttcagcc agttcaaccg gcggttcctg aacgtcgtgc ggcagttctc tgataacgcc      600

ggcatcaccc ctgccatcag cctggatctg atgaccgatg ccgagctggc tagagccgtg      660

tccaacatgc ctacctctgc cggccagatc aagctgatgc tggaaaacag agccatggtc      720

cgacggaaag gcttcggctt tctgatcggc gtgtacggct cctccgtgat ctacatggtg      780

cagctgccta tcttcggcgt gatcgacacc ccttgctgga tcgtgaaggc cgctcctagc      840

tgctctgaga agaagggcaa ctacgcctgc ctgctgagag aggaccaagg ctggtactgt      900

cagaacgccg gctccaccgt gtactacccc aacgagaagg actgcgagac aagaggcgac      960

cacgtgttct gcgatacctg cgctggcatc aatgtggccg agcagtccaa agagtgcaac     1020

atcaacatct ccaccaccaa ctatccctgc aaggtgtcca ccggcaggca ccctatttcc     1080

atggtggctc tgtctccact gggcgccctg gtggcttgtt ataagggcgt gtcctgctcc     1140

atcggctcca acagagtggg catcatcaag cagctgaaca agggctgcag ctacatcacc     1200

aaccaggacg ccgataccgt gaccatcgac aataccgtgt atcagctgtc caaggtggaa     1260

ggcgagcagc acgtgatcaa gggcagacct gtgtcctcca gcttcgaccc cgtgaagttc     1320

cctgaggatc agttcaacgt ggccctggac caggtgttcg agtccatcga gaactctcag     1380

gctctggtgg accagtccaa ccggatcctg tcctctgccg agtctgctat cggcggctat     1440

atccccgagg ctcctagaga tggccaggcc tatgttcgga aggatggcga atgggtgctg     1500

ctgtctacct tcctcggagg cctggtgcct agaggctctc accaccatca tcaccactcc     1560

gcttggtccc atccacagtt cgagaagtga                                      1590


<210>  24
<211>  487
<212>  PRT
<213>  artificial

<220>
<223>  Artificial

<400>  24

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu 
            20                  25                  30          


Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gln Pro 
65                  70                  75                  80  


Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala Ile Ala 
                85                  90                  95      


Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu 
            100                 105                 110         


Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val 
        115                 120                 125             


Leu Ala Phe Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu 
    130                 135                 140                 


Thr Arg Ala Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met 
145                 150                 155                 160 


Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg 
                165                 170                 175     


Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu 
            180                 185                 190         


Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser 
        195                 200                 205             


Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg 
    210                 215                 220                 


Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr 
225                 230                 235                 240 


Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile 
                245                 250                 255     


Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys 
            260                 265                 270         


Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr 
        275                 280                 285             


Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val 
    290                 295                 300                 


Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu 
305                 310                 315                 320 


Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr 
                325                 330                 335     


Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu 
            340                 345                 350         


Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val 
        355                 360                 365             


Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln 
    370                 375                 380                 


Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys 
385                 390                 395                 400 


Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser 
                405                 410                 415     


Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp 
            420                 425                 430         


Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser 
        435                 440                 445             


Asn Arg Ile Leu Ser Ser Ala Glu Ser Ala Ile Gly Gly Tyr Ile Pro 
    450                 455                 460                 


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
465                 470                 475                 480 


Val Leu Leu Ser Thr Phe Leu 
                485         


<210>  25
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  25

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu 
            20                  25                  30          


Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gln Pro 
65                  70                  75                  80  


Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala Ile Ala 
                85                  90                  95      


Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu 
            100                 105                 110         


Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val 
        115                 120                 125             


Leu Ala Thr Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu 
    130                 135                 140                 


Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met 
145                 150                 155                 160 


Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg 
                165                 170                 175     


Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu 
            180                 185                 190         


Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser 
        195                 200                 205             


Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg 
    210                 215                 220                 


Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr 
225                 230                 235                 240 


Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile 
                245                 250                 255     


Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys 
            260                 265                 270         


Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr 
        275                 280                 285             


Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val 
    290                 295                 300                 


Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu 
305                 310                 315                 320 


Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr 
                325                 330                 335     


Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu 
            340                 345                 350         


Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val 
        355                 360                 365             


Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln 
    370                 375                 380                 


Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys 
385                 390                 395                 400 


Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser 
                405                 410                 415     


Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp 
            420                 425                 430         


Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser 
        435                 440                 445             


Asn Arg Ile Leu Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    450                 455                 460                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
465                 470                 475                 480 


Leu 
    


<210>  26
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  26

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Met Leu 
            20                  25                  30          


Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Leu Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Asn Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gln Pro 
65                  70                  75                  80  


Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala Ile Ala 
                85                  90                  95      


Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu 
            100                 105                 110         


Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val 
        115                 120                 125             


Leu Ala Thr Met Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu 
    130                 135                 140                 


Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met 
145                 150                 155                 160 


Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg 
                165                 170                 175     


Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu 
            180                 185                 190         


Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser 
        195                 200                 205             


Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg 
    210                 215                 220                 


Lys Gly Phe Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr 
225                 230                 235                 240 


Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile 
                245                 250                 255     


Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys 
            260                 265                 270         


Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr 
        275                 280                 285             


Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val 
    290                 295                 300                 


Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu 
305                 310                 315                 320 


Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr 
                325                 330                 335     


Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu 
            340                 345                 350         


Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val 
        355                 360                 365             


Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln 
    370                 375                 380                 


Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys 
385                 390                 395                 400 


Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser 
                405                 410                 415     


Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp 
            420                 425                 430         


Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser 
        435                 440                 445             


Asn Arg Ile Leu Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    450                 455                 460                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
465                 470                 475                 480 


Leu 
    


<210>  27
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  27

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Met Leu 
            20                  25                  30          


Cys Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Leu Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gln Pro 
65                  70                  75                  80  


Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala Ile Ala 
                85                  90                  95      


Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu 
            100                 105                 110         


Lys Lys Thr Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val 
        115                 120                 125             


Leu Ala Thr Met Val Arg Glu Leu Cys Asp Phe Val Ser Lys Asn Leu 
    130                 135                 140                 


Thr Arg Ala Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met 
145                 150                 155                 160 


Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg 
                165                 170                 175     


Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu 
            180                 185                 190         


Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser 
        195                 200                 205             


Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg 
    210                 215                 220                 


Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Asp Val Ile Tyr 
225                 230                 235                 240 


Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile 
                245                 250                 255     


Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys 
            260                 265                 270         


Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr 
        275                 280                 285             


Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val 
    290                 295                 300                 


Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu 
305                 310                 315                 320 


Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr 
                325                 330                 335     


Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu 
            340                 345                 350         


Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val 
        355                 360                 365             


Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln 
    370                 375                 380                 


Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys 
385                 390                 395                 400 


Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser 
                405                 410                 415     


Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp 
            420                 425                 430         


Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser 
        435                 440                 445             


Asn Arg Cys Cys Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    450                 455                 460                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
465                 470                 475                 480 


Leu 
    


<210>  28
<211>  487
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  28

Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly 
1               5                   10                  15      


Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Met Leu 
            20                  25                  30          


Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu 
        35                  40                  45              


Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg 
    50                  55                  60                  


Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gln Pro 
65                  70                  75                  80  


Arg Gln Ser Gly Cys Gly Ala Gly Ala Thr Ala Gly Val Ala Ile Ala 
                85                  90                  95      


Lys Thr Ile Arg Leu Glu Ser Glu Val Thr Ala Trp Lys Asn Ala Leu 
            100                 105                 110         


Lys Lys Thr Asn Glu Val Val Ser Thr Leu Gly Asn Gly Val Arg Val 
        115                 120                 125             


Leu Val Thr Met Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu 
    130                 135                 140                 


Thr Arg Ala Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met 
145                 150                 155                 160 


Ala Val Ser Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg 
                165                 170                 175     


Gln Phe Ser Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu 
            180                 185                 190         


Met Thr Asp Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser 
        195                 200                 205             


Ala Gly Gln Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg 
    210                 215                 220                 


Lys Gly Phe Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr 
225                 230                 235                 240 


Met Val Gln Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile 
                245                 250                 255     


Val Lys Ala Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys 
            260                 265                 270         


Leu Leu Arg Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr 
        275                 280                 285             


Val Tyr Tyr Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val 
    290                 295                 300                 


Phe Cys Asp Thr Cys Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu 
305                 310                 315                 320 


Cys Asn Ile Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr 
                325                 330                 335     


Gly Arg His Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu 
            340                 345                 350         


Val Ala Cys Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val 
        355                 360                 365             


Gly Ile Ile Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln 
    370                 375                 380                 


Asp Ala Asp Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys 
385                 390                 395                 400 


Val Glu Gly Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser 
                405                 410                 415     


Phe Asp Pro Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp 
            420                 425                 430         


Gln Val Phe Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser 
        435                 440                 445             


Asn Arg Ile Leu Ser Ser Ala Glu Ser Ala Ile Gly Gly Tyr Ile Pro 
    450                 455                 460                 


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
465                 470                 475                 480 


Val Leu Leu Ser Thr Phe Leu 
                485         


<210>  29
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  29

Gly Tyr Ile Pro Glu Ala Pro Arg Asn Gly Thr Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  30
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  30

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asn Gly Thr Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  31
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  31

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Asn Trp Thr Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  32
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  32

Gly Tyr Ile Pro Glu Ala Pro Arg Asn Gly Thr Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asn Gly Thr Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  33
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  33

Gly Tyr Ile Pro Glu Ala Pro Arg Asn Gly Thr Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Asn Trp Thr Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  34
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  34

Ile Leu Ser Ala 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  35

Cys Cys Ser Ala 
1               


<210>  36
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  36

Cys Cys Lys Gln Thr Asn Glu Cys Cys Lys Asn Leu Glu Arg Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  37
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  37

Cys Cys Arg Glu Leu Lys Glu Cys Cys Lys Asn Leu Glu Asn Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  38
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  38

Cys Cys Arg Glu Leu Lys Asp Cys Cys Lys Asn Leu Glu Asn Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  39
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  39

Cys Cys Arg Glu Leu Lys Asp Cys Cys Lys Asn Leu Glu Arg Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  40
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  40

Cys Cys Arg Glu Leu Lys Asp Cys Cys Lys Gln Leu Asn Lys Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  41
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  41

Cys Cys Arg Glu Leu Lys Glu Cys Cys Lys Gln Leu Asn Lys Ala Val 
1               5                   10                  15      


Ser Ala 
        


<210>  42
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  42

Leu Val Pro Arg Gly Ser 
1               5       


<210>  43
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  43

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  44
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  44

Ile Glu Gly Arg 
1               


<210>  45
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  45

Cys Cys Lys Gln Thr Asn Glu Cys Cys Lys Asn Leu Glu Arg Ala Val 
1               5                   10                  15      


Ser 
    


<210>  46
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  46

Cys Cys Lys Gln Thr Asn Glu Cys Cys Lys Asn Leu Glu Arg Ala Val 
1               5                   10                  15      


Ser 
    


<210>  47
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  47

Cys Cys Lys Gln Thr Asn Glu Cys Cys Lys Asn Leu Glu Arg Ala Val 
1               5                   10                  15      


Ser 
    


<210>  48
<211>  17
<212>  PRT
<213>  Artficial

<400>  48

Cys Cys Arg Glu Leu Lys Glu Cys Cys Lys Asn Leu Glu Asn Ala Val 
1               5                   10                  15      


Ser 
    


<210>  49
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  49

Cys Cys Arg Glu Leu Lys Glu Cys Cys Lys Asn Leu Glu Asn Ala Val 
1               5                   10                  15      


Ser 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  50

Cys Cys Arg Glu Leu Lys Glu Cys Cys Lys Asn Leu Glu Asn Ala Val 
1               5                   10                  15      


Ser 
    


<210>  51
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  51

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro 
                485                 490                 495     


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
            500                 505                 510         


Ser Thr Phe Leu Gly Gly Leu Val Pro Arg Gly Ser His His His His 
        515                 520                 525             


His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    530                 535                 540 


<210>  52
<211>  1623
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  52
atgtcttgga aggtggtcat catcttctcc ctgctgatca cccctcagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgaga      120

accggctggt acaccaacgt gttcaccctg gaagtgggcg acgtggaaaa cctgacctgt      180

gctgatggcc ccagcctgat caagaccgag ctggacctga ccaagtctgc cctgagagaa      240

ctgaggaccg tgtctgccga tcagctggcc agagaggaac agatcgagaa ccctcggcag      300

tccagattcg tgctgggagc tattgctctg ggcgtgtgta cagccgctgc tgtgacagct      360

ggtgtcgcta tcgccaagac catccggctg gaatctgaag tgaccgccat caagaacgcc      420

ctgaaaaaga ccaacgaggc cgtgtccaca ctcggcaatg gcgttagagt gctggccttt      480

gctgtgcgcg agctgaagga cttcgtgtcc aagaacctga ccagggctct gaacaagaac      540

aagtgtgata tcgccgacct gaagatggcc gtgtctttca gccagttcaa ccggcggttc      600

ctgaacgtcg tgcggcagtt ctctgataac gccggcatca cccctgccat cagcctggat      660

ctgatgaccg atgccgagct ggctagagcc gtgtctaaca tgcctacctc tgccggccag      720

atcaagctga tgctggaaaa cagagccatg gtccgacgga aaggcttcgg ctttctgatc      780

ggcgtgtacg gctcctccgt gatctacatg gtgcagctgc ctatcttcgg cgtgatcgac      840

accccttgct ggatcgtgaa ggccgctcct agctgctctg agaagaaggg caactacgcc      900

tgcctgctga gagaggacca aggctggtac tgtcagaacg ccggctccac cgtgtactac      960

cccaacgaga aggactgcga gacaagaggc gaccacgtgt tctgcgatac cgcctgtggc     1020

atcaatgtgg ccgagcagtc caaagagtgc aacatcaaca tctccaccac caactatccc     1080

tgcaaggtgt ccaccggcag gcaccctatt tccatggtgg ctctgtctcc actgggcgcc     1140

ctggtggctt gttataaggg cgtgtcctgc tccatcggct ccaacagagt gggcatcatc     1200

aagcagctga acaagggctg cagctacatc accaaccagg acgccgatac cgtgaccatc     1260

gacaataccg tgtatcagct gtccaaggtg gaaggcgagc agcacgtgat caagggcaga     1320

cctgtgtcct ccagcttcga ccccgtgaag ttccctgagg atcagttcaa cgtggccctg     1380

gaccaggtgt tcgagtccat cgagaactct caggctctgg tggaccagtc caaccggatc     1440

ctgtcctctg ccgagtctgc tatcggcggc tatatccccg aggctcctag agatggccag     1500

gcctatgttc ggaaggatgg cgaatgggtg ctgctgtcta ccttcctcgg aggcctggtg     1560

cctagaggct ctcaccacca tcatcaccac tccgcttggt cccatccaca gttcgagaag     1620

tga                                                                   1623


<210>  53
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  53

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Lys Lys Arg Lys Arg Arg Val Ala Thr Ala Ala 
            100                 105                 110         


Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu Ser 
        115                 120                 125             


Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala Val 
    130                 135                 140                 


Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg Glu 
145                 150                 155                 160 


Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys Asn 
                165                 170                 175     


Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln Phe 
            180                 185                 190         


Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala Gly 
        195                 200                 205             


Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu Ala 
    210                 215                 220                 


Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu Met 
225                 230                 235                 240 


Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu Ile 
                245                 250                 255     


Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile Phe 
            260                 265                 270         


Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser Cys 
        275                 280                 285             


Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln Gly 
    290                 295                 300                 


Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu Lys 
305                 310                 315                 320 


Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala Gly 
                325                 330                 335     


Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser Thr 
            340                 345                 350         


Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser Met 
        355                 360                 365             


Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly Val 
    370                 375                 380                 


Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn 
385                 390                 395                 400 


Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr Ile 
                405                 410                 415     


Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His Val 
            420                 425                 430         


Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe Pro 
        435                 440                 445             


Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile Glu 
    450                 455                 460                 


Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Lys Gly Asn Thr Ser Gly Arg Glu Asn Leu Tyr Phe Gln Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
            500                 505                 510         


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly 
        515                 520                 525             


Ile Glu Gly Arg His His His His His His 
    530                 535             


<210>  54
<211>  1617
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial

<400>  54
atgtcctgga aggtcgtgat catcttctcc ctgctgatca ccccccagca cggcctgaaa       60

gagtcctacc tggaagagag ctgctccacc atcaccgagg gctacctgtc tgtgctgcgg      120

accggctggt acaccaacgt gttcaccctg gaagtgggcg acgtggaaaa cctgacctgc      180

gccgatggcc ccagcctgat caagaccgag ctggacctga ccaagtccgc cctgcgggaa      240

ctgagaaccg tgtctgccga tcagctggcc agagaggaac agatcgagaa cccccggcag      300

tccaagaaac ggaagcggag agtggccacc gccgctgctg tgacagctgg cgtggccatt      360

gccaagacca tccggctgga atccgaagtg accgccatca agaacgccct gaaaaagacc      420

aacgaggccg tgtctaccct gggcaatggc gtgcgagtgc tggctacagc tgtgcgcgag      480

ctgaaggact tcgtgtccaa gaacctgacc cgggccatca acaagaacaa gtgtgatatc      540

gccgacctga agatggccgt gtcctttagc cagttcaacc ggcggttcct gaacgtcgtg      600

cggcagttct ctgacaacgc cggcatcacc cctgccatct ccctggatct gatgaccgac      660

gccgagctgg ctagagccgt gtccaacatg cctacctctg ccggccagat caagctgatg      720

ctggaaaacc gggccatggt gcgacggaag ggcttcggct ttctgatcgg cgtgtacggc      780

tcctccgtga tctacatggt gcagctgcct atcttcggcg tgatcgacac cccctgctgg      840

atcgtgaagg ccgctcctag ctgctccgag aagaagggca actacgcctg cctgctgaga      900

gaggaccagg gctggtactg tcagaacgcc ggctccaccg tgtactaccc caacgagaag      960

gactgcgaga cacggggcga ccacgtgttc tgtgataccg ctgctggcat caacgtggcc     1020

gagcagtcca aagagtgcaa catcaacatc tccaccacca actacccctg caaggtgtcc     1080

accggcaggc accccatctc tatggtggcc ctgtctcctc tgggcgccct ggtggcttgt     1140

tacaagggcg tgtcctgctc catcggctcc aacagagtgg gcatcatcaa gcagctgaac     1200

aagggctgca gctacatcac caaccaggac gccgacaccg tgaccatcga caataccgtg     1260

tatcagctgt ccaaggtgga aggcgagcag cacgtgatca agggcagacc cgtgtcctcc     1320

agcttcgacc ccgtgaagtt ccccgaggat cagttcaatg tggccctgga ccaggtgttc     1380

gagtccatcg agaactccca ggctctggtg gaccagtcca accggatcct gtcctctgcc     1440

gagaagggaa acacctccgg cagagagaac ctgtattttc aaggcggcgg aggctccggc     1500

tacatccctg aggctcctag agatggccag gcctacgtgc ggaaggatgg cgaatgggtg     1560

ctgctgtcca ccttcctggg cggcatcgag ggcagacacc accatcatca ccactga        1617


