               SEQUENCE LISTING

<110> AC Immune S.A

<120> Anti-TDP-43 binding molecules and uses thereof

<130> P215020WO00

<160> 159

<170> BiSSAP 1.3.6

<210> 1
<211> 414
<212> PRT
<213> Artificial Sequence


<220> 
<223> Q13148

<400> 1
Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      
Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          
Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              
Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  
Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  
Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      
Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         
Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             
Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 
Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 
Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     
Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         
Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             
Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 
Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 
Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     
Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         
Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             
Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 
Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 
Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     
Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         
Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             
Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 
Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 
Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 

<210> 2
<400> 2
000

<210> 3
<400> 3
000

<210> 4
<400> 4
000

<210> 5
<400> 5
000

<210> 6
<400> 6
000

<210> 7
<400> 7
000

<210> 8
<400> 8
000

<210> 9
<400> 9
000

<210> 10
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VH

<400> 10
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Ser Ile His Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Gly Ile Asn Pro Asp Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     

<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VH CDR1

<400> 11
Glu Tyr Ser Ile His 
1               5   

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VH CDR2

<400> 12
Gly Ile Asn Pro Asp Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VH CDR3

<400> 13
Glu Ser Xaa Xaa Xaa 
1               5   

<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-AB1 VL

<400> 14
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Arg Ile Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-AB1 VL CDR1

<400> 15
Lys Ser Ser Gln Ser Leu Leu Asn Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-AB1 VL CDR2

<400> 16
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VL CDR3

<400> 17
Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   

<210> 18
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VH

<400> 18
gaggtccagc tgcaacagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcctgcaaga cttctggata cacattcact gaatactcca tacactgggt gaaacagagc     120

catggagaga gccttgagtg gattggaggt attaatcctg acaatggtgg tactaggtac     180

aaccagaagt tcaagggcaa ggcgacattg actgtagaca agtcctccag cacagcctac     240

atggacctcc gcagcctgac atctgaggat tctgcagttt attattgtgc aagagagtcc     300

tggggccaag gcaccactct cacagtctcc tct                                  333


<210> 19
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-631B2-Ab1 VL

<400> 19
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta aatagtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctagaatcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cacacgttcg gttctgggac caagctggag ctgaaa                               336


<210> 20
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VH

<400> 20
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Glu Tyr 
            20                  25                  30          
Ser Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VH CDR1

<400> 21
Glu Tyr Ser Met His 
1               5   

<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VH CDR2

<400> 22
Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VH CDR3

<400> 23
Glu Ser Xaa Xaa Xaa 
1               5   

<210> 24
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VL

<400> 24
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Arg Ile Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VL CDR1

<400> 25
Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 26
<400> 26
000

<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VL CDR3

<400> 27
Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   

<210> 28
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VH

<400> 28
gaggtccagc tgcaacagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcctgcaaga cttctggatt cacattcact gaatactcca tgcactgggt gaaacagagc     120

catggaaaga gccttgagtg gattggaggt attaatccta acaatggtgg tactagctac     180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac     240

atggagctcc gcagcctaac atctgaggat tctgcagtct attactgtgc aagagagtcc     300

tggggccaag gcaccactct cacagtctcc tca                                  333


<210> 29
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-633B12-Ab1 VL

<400> 29
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta catagtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctagaatcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cacacgttcg gtgctgggac caagctggag ctgaaa                               336


<210> 30
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VH

<400> 30
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Ser Asn Thr Lys Phe Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Tyr Gly Gly Ser His Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VH CDR1

<400> 31
Asp Thr Tyr Met His 
1               5   

<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VH CDR2

<400> 32
Arg Ile Asp Pro Ala Asn Ser Asn Thr Lys Phe Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VH CDR3

<400> 33
Phe Tyr Gly Gly Ser His Trp Tyr Phe Asp Val 
1               5                   10      

<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VL

<400> 34
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln His Lys Pro Trp Lys Ser Pro Lys Ala Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln Gln Gly Glu Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VL CDR1

<400> 35
Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      

<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VL CDR2

<400> 36
Tyr Ala Thr Ser Leu Ala Asp 
1               5           

<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VL CDR3

<400> 37
Leu Gln Gln Gly Glu Ser Pro Tyr Thr 
1               5                   

<210> 38
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VH

<400> 38
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaggttg      60

tcctgcacag cttctggctt caacattaaa gacacctata tgcactgggt gaagcagagg     120

cctgaacagg gcctggaatg gattggaagg attgatcctg cgaatagtaa tactaaattt     180

gacccgaagt tccagggcaa ggccactata acatcagaca catcctccaa cacagcctac     240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagattctac     300

ggtggtagcc actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca     360


<210> 39
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-634H10-Ab2 VL

<400> 39
gacatcaaga tgacccagtc tccatcctcc atgtatgcat cgttgggaga gagagtcact      60

atcacttgca aggcgagtca ggacattaaa agctatttaa gctggtacca gcataaacca     120

tggaaatctc ctaaggccct gatctattat gctacaagct tggcagatgg ggtcccatca     180

agattcagtg gcagtggatc tgggcaagat tattctctaa ccatcagcag cctggagtct     240

gacgatacag caacttacta ctgtctacag caaggtgaga gcccgtacac gttcggaggg     300

gggaccaagc tggaaataaa a                                               321


<210> 40
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VH

<400> 40
Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Met Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Lys Tyr Ile Asn Tyr Leu Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Tyr Gly Ser Gly Trp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 

<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VH CDR1

<400> 41
Asn Tyr Gly Met Ser 
1               5   

<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VH CDR2

<400> 42
Thr Ile Ser Ser Gly Gly Lys Tyr Ile Asn Tyr Leu Asp Ser Leu Lys 
1               5                   10                  15      
Gly 
    

<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VH CDR3

<400> 43
Asp Tyr Gly Ser Gly Trp Ala Trp Phe Ala Tyr 
1               5                   10      

<210> 44
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VL

<400> 44
Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      
Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          
Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              
Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  
Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      
Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         
Thr Val Leu 
        115 

<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VL CDR1

<400> 45
Thr Leu Ser Ser Gln His Ser Thr Tyr Thr Ile Glu 
1               5                   10          

<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VL CDR2

<400> 46
Gly Ser His Ser Thr Gly Asp 
1               5           

<210> 47
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VL CDR3

<400> 47
Gly Val Gly Asp Thr Ile Lys Glu Gln Phe Val Tyr Val 
1               5                   10              

<210> 48
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VH

<400> 48
gaggtacatc tggtggagtc tgggggagac ttagtgatgc ctggagggtc cctgaagctc      60

tcctgtgcag cctctggatt cactttcagt aactatggca tgtcttgggt tcgccagact     120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtaaata tatcaactac     180

ttagacagtt tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctatac     240

ctgcaaatga gcagtctgaa gtctgaggat acagccatgt attactgtgc aaaagactac     300

ggtagtggct gggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca     360


<210> 49
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-636E5-Ab1 VL

<400> 49
caacttgtgc tcactcagtc atcttcagcc tctttctccc tgggagcctc agcaaaactc      60

acgtgcacct tgagtagtca gcacagtacg tacaccattg aatggtatca gcaacagcca     120

ctcaagcctc ctaagtatgt gatggagctt aagaaagatg gaagccacag cacaggtgat     180

gggattcctg atcgcttctc tggatccagc tctggtgctg atcgctacct tagcatttcc     240

aacatccagc ctgaagatga agcaatatac atctgtggtg tgggtgatac aattaaggaa     300

caatttgtgt atgttttcgg cggtggaacc aaggtcactg tccta                     345


<210> 50
<400> 50
000

<210> 51
<400> 51
000

<210> 52
<400> 52
000

<210> 53
<400> 53
000

<210> 54
<400> 54
000

<210> 55
<400> 55
000

<210> 56
<400> 56
000

<210> 57
<400> 57
000

<210> 58
<400> 58
000

<210> 59
<400> 59
000

<210> 60
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VH

<400> 60
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Leu Met Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      
Ile Tyr Arg Thr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VH CDR1

<400> 61
Asn Tyr Gly Val His 
1               5   

<210> 62
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VH CDR2

<400> 62
Leu Met Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      



<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VH CDR3

<400> 63
Tyr Arg Thr Gly Phe Ala Tyr 
1               5           

<210> 64
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VL

<400> 64
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Thr 
            20                  25                  30          
Ile Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 65
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VL CDR1

<400> 65
Arg Ser Ser Gln Ser Ile Val His Thr Ile Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VL CDR2

<400> 66
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VL CDR3

<400> 67
Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   

<210> 68
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VH

<400> 68
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acttgtactg tctctgggtt ttcattaacc aactatggtg tacactgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggacta atgtgggctg gtggaagcac aaattataat     180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagtca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgtcat ctataggacg     300

gggtttgctt actggggcca agggactctg gtcactgtct ctgca                     345


<210> 69
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-641H1-Ab2 VL

<400> 69
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catactattg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccggttt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcca     300

ttcactttcg gctcggggac aaagttggaa ataaaa                               336


<210> 70
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VH

<400> 70
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 71
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VH CDR1

<400> 71
Lys Tyr Trp Met His 
1               5   

<210> 72
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VH CDR2

<400> 72
Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Ser 
    

<210> 73
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VH CDR3

<400> 73
Tyr Met Asp Tyr 
1               

<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VL

<400> 74
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asp Arg 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 75
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VL CDR1

<400> 75
Lys Ser Ser Gln Ser Leu Phe Asp Arg Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 76
<400> 76
000

<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VL CDR3

<400> 77
Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   

<210> 78
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VH

<400> 78
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcacc aagtactgga tgcactgggt gaagcagagg     120

cctggacaag gccttgagtg gattggagag attaatccta gcaacggtcg tactaactac     180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac     240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagatatatg     300

gactactggg gtcaaggaac ctcagtcacc gtctcctca                            339


<210> 79
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-642A10-ab1 VL

<400> 79
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctcttt gatcgtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 80
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VH

<400> 80
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Pro 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Arg Pro Lys Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asp Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Val Ala Tyr 
65                  70                  75                  80  
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Tyr Gly Ser Ser His Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VH CDR1

<400> 81
Asp Pro Tyr Met His 
1               5   

<210> 82
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VH CDR2

<400> 82
Arg Ile Asp Pro Ala Asp Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 83
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VH CDR3

<400> 83
Phe Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10      

<210> 84
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VL

<400> 84
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Arg Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Ile Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Thr Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gln Gly Glu Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 85
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VL CDR1

<400> 85
Lys Ala Ser Gln Asp Ile Lys Arg Tyr Leu Ser 
1               5                   10      

<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VL CDR2

<400> 86
Tyr Ala Thr Ser Leu Ala Asp 
1               5           

<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VL CDR3

<400> 87
Leu Gln Gln Gly Glu Ser Pro Tyr Thr 
1               5                   

<210> 88
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VH

<400> 88
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc cgggggcctc agtcaggttg      60

tcctgcacag cttctggctt caacattaaa gacccctata tgcactgggt caggcagagg     120

cctaaacagg gcctggagtg gattggaagg attgatcctg cggatggtaa tactaaatat     180

gacccgaagt tccagggcaa ggccacttta acagcagaca catcctccaa tgtagcctac     240

ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtgc tagattctac     300

ggtagtagcc actggtattt cgatgtgtgg ggcgcaggga ccacggtcac cgtctcctca     360


<210> 89
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-642D12-Ab1 VL

<400> 89
gacatcaaga tgacccagtc tccatcctcc atgtatgcat cgttgggaga gagagtcact      60

atcacttgca aggcgagtca ggacattaaa aggtatttaa gctggtacca gcagaaacca     120

tggaaatctc ctaagatcct gatctattat gcaacaagct tggcagatgg ggtcccatca     180

agattcagtg gcactggatc tggacaagat tattctctaa ccatcagcag cctggagtct     240

gacgatgtag caacttacta ctgtctacag caaggtgaga gcccgtacac gttcggaggg     300

gggaccaagc tggaaataaa a                                               321


<210> 90
<400> 90
000

<210> 91
<400> 91
000

<210> 92
<400> 92
000

<210> 93
<400> 93
000

<210> 94
<400> 94
000

<210> 95
<400> 95
000

<210> 96
<400> 96
000

<210> 97
<400> 97
000

<210> 98
<400> 98
000

<210> 99
<400> 99
000

<210> 100
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VH

<400> 100
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Ile Met Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      
Ile Tyr Lys Thr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210> 101
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VH CDR1

<400> 101
Asn Phe Gly Val His 
1               5   

<210> 102
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VH CDR2

<400> 102
Ile Met Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      



<210> 103
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VH CDR3

<400> 103
Tyr Lys Thr Gly Phe Ala Tyr 
1               5           

<210> 104
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VL

<400> 104
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ala 
            20                  25                  30          
Ile Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 105
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VL CDR1

<400> 105
Arg Ser Ser Gln Ser Ile Val His Ala Ile Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VL CDR2

<400> 106
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VL CDR2

<400> 107
Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   

<210> 108
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VH

<400> 108
caggtgcaac tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acttgtactg tctctggatt ttcattaacc aactttggtg tacactgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggaata atgtgggctg gtggaagcac aaattataat     180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagtca agttttctta     240

aaaatgaaca gtctccaaac tgatgacaca gccatgtact actgtgtcat ctataagacg     300

gggtttgctt actggggcca agggactctg gtcactgtct ctgca                     345


<210> 109
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7069-646B7-Ab1 VL

<400> 109
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catgctattg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccggttt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcca     300

ttcacgttcg gctcggggac aaagttggaa ataaaa                               336


<210> 110
<400> 110
000

<210> 111
<400> 111
000

<210> 112
<400> 112
000

<210> 113
<400> 113
000

<210> 114
<400> 114
000

<210> 115
<400> 115
000

<210> 116
<400> 116
000

<210> 117
<400> 117
000

<210> 118
<400> 118
000

<210> 119
<400> 119
000

<210> 120
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VH

<400> 120
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Ala Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Ile His Trp Ile Lys Gln Lys Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Phe His Pro Glu Asn Asp Asn Ile Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Gly Thr Ser Gly Tyr Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 121
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VH CDR1

<400> 121
Glu Tyr Thr Ile His 
1               5   

<210> 122
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VH CDR2

<400> 122
Trp Phe His Pro Glu Asn Asp Asn Ile Lys Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 123
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VH CDR3

<400> 123
Thr Ser Gly Tyr Gly Asp Tyr 
1               5           

<210> 124
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VL

<400> 124
Asp Val Val Met Thr Gln Ile Pro Leu Thr Leu Ser Ile Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Pro Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 125
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VL CDR1

<400> 125
Lys Ser Ser Gln Ser Leu Leu Pro Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 126
<400> 126
000

<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VL CDR3

<400> 127
Trp Gln Gly Thr His Phe Pro Pro Thr 
1               5                   

<210> 128
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VH

<400> 128
caggtccagc tgcagcagtc tggagctgag ctggtgaaac ccgggacatc agtgaagctg      60

tcctgtaagg cttctgccta caccttcact gaatatacta tacactggat aaagcagaaa     120

tctggacagg gtcttgagtg gattgggtgg tttcaccctg aaaatgataa tataaagtac     180

aatgagaatt tcaaggacaa ggccacattg actgcggaca gatcctccag cacagtctat     240

atggaactta gtagattgac atctgaagac tctgcggtct atttctgtgc agggacgtca     300

ggctacggag actactgggg ccaaggcacc actctcacag tctcttca                  348


<210> 129
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-712A6-Ab1 VL

<400> 129
gatgttgtga tgacccagat tccactcact ttgtcgatta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta cctagtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgacga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cctacgttcg gtgctgggac caagctggaa ctgaaa                               336


<210> 130
<400> 130
000

<210> 131
<400> 131
000

<210> 132
<400> 132
000

<210> 133
<400> 133
000

<210> 134
<400> 134
000

<210> 135
<400> 135
000

<210> 136
<400> 136
000

<210> 137
<400> 137
000

<210> 138
<400> 138
000

<210> 139
<400> 139
000

<210> 140
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VH

<400> 140
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Lys Phe Thr Asp Tyr 
            20                  25                  30          
Ser Met His Trp Val Lys Gln Ser His Thr Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Ser Thr Tyr Tyr Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Ile Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Tyr Gly Asn Phe Pro Ala Ser Phe Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 141
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VH CDR1

<400> 141
Asp Tyr Ser Met His 
1               5   

<210> 142
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VH CDR2

<400> 142
Val Ile Ser Thr Tyr Tyr Gly Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 143
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VH CDR3

<400> 143
Tyr Gly Asn Phe Pro Ala Ser Phe Ser Tyr 
1               5                   10  

<210> 144
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VL

<400> 144
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 145
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VL CDR1

<400> 145
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      



<210> 146
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VL CDR2

<400> 146
Arg Met Ser Asn Leu Ala Ser 
1               5           

<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VL CDR3

<400> 147
Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   

<210> 148
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VH

<400> 148
caggtccagc tgcagcagtc tggggctgag ctggtgaggc ctggggtctc agtgaagatt      60

tcctgcaagg gttctggcta caaattcact gattattcta tgcactgggt gaaacagagt     120

catacaaaga gtctagagtg gattggagtt attagtactt actatggtga tactacctac     180

aaccagaaat tcaagggcaa ggccacaatc actgtagaca aatcctccag cacagcctat     240

atggaacttg ccagactgac atctgaggat tctgccatct attactgtgc aacgtacggt     300

aacttcccgg cctcattttc ttactggggc caagggactc tggtcactgt ctctgca        357


<210> 149
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-809D9-Ab2 VL

<400> 149
gatattgtga tgactcaggc tgcaccctct atacctgtca ctcctggaga gtcagtatcc      60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg     120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc     180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc     240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca     300

ttcacgttcg gctcggggac aaagttggaa ataaaa                               336


<210> 150
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VH

<400> 150
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Arg Asn 
            20                  25                  30          
Gly Val Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Pro Gly Gly Ser Thr Asn Cys Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu His Thr Asp Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Val Gly Gly Asn Tyr Val Trp Asp Tyr Asn Asn Tyr Ala Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     

<210> 151
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VH CDR1

<400> 151
Arg Asn Gly Val Gln 
1               5   

<210> 152
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VH CDR2

<400> 152
Val Ile Trp Pro Gly Gly Ser Thr Asn Cys Asn Ser Ala Leu Met Ser 
1               5                   10                  15      



<210> 153
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VH CDR3

<400> 153
Val Gly Gly Asn Tyr Val Trp Asp Tyr Asn Asn Tyr Ala 
1               5                   10              

<210> 154
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VL

<400> 154
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          
Ile Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         



<210> 155
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VL CDR1

<400> 155
Arg Ser Ser Gln Asn Ile Val His Ser Ile Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 156
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VL CDR2

<400> 156
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 157
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VL CDR3

<400> 157
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 158
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VH

<400> 158
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acttgcactg tctctgggtt ttcgttaaac agaaatggtg tacagtgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggagta atatggcctg gcggaagcac aaattgtaat     180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagtca agttttctta     240

aaaatgaaca gtctgcacac tgatgacaca ggcatatatt actgtgccag agtagggggt     300

aactacgtgt gggactataa taactacgcc tggggccaag ggactctggt cactgtctct     360

gca                                                                   363


<210> 159
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7071-809F12-Ab1 VL

<400> 159
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaggcctcc      60

atctcttgca gatctagtca gaacattgta catagtattg gaaacaccta tttagagtgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg     300

tacacgttcg gaggggggac caagctagaa ataaga                               336


