                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Zika Virus Constructs and Therapeutic Compositions Thereof

<130>  034044204WO1

<150>  US 62/850,759
<151>  2019-05-21

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E protein of ZIKV having N154X substitution


<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  Wherein Xaa is any amino acid residue other than Asn

<400>  1

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Xaa Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Leu Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  2
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E protein of wild-type ZIKV

<400>  2

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Leu Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  3
<211>  273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding human CCL5

<400>  3
atgaaggtct ccgcggcagc cctcgctgtc atcctcattg ctactgccct ctgcgctcct       60

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc      120

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca      180

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg      240

gttcgggagt acatcaactc tttggagatg agc                                   273


<210>  4
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding human IL18

<400>  4
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac       60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag      120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa      180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg      240

accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc      300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag      360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga      420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt      480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg      540

ggggatagat ctataatgtt cactgttcaa aacgaagac                             579


<210>  5
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding human IL2

<400>  5
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgact                             459


<210>  6
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding human TNFS14

<400>  6
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca       60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggtgggtctg      120

ggtctcttgc tgttgctgat gggggccggg ctggccgtcc aaggctggtt cctcctgcag      180

ctgcactggc gtctaggaga gatggtcacc cgcctgcctg acggacctgc aggctcctgg      240

gagcagctga tacaagagcg aaggtctcac gaggtcaacc cagcagcgca tctcacaggg      300

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg      360

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac      420

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc      480

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg      540

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc      600

agcttcctgg gtggtgtggt acacctggag gctggggaga aggtggtcgt ccgtgtgctg      660

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg      720


<210>  7
<211>  14020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika Vector sequence

<400>  7
gaattctcaa tattggccat tagccatatt attcattggt tatatagcat aaatcaatat       60

tggctattgg ccattgcata cgttgtatct atatcataat atgtacattt atattggctc      120

atgtccaata tgaccgccat gttggcattg attattgact agttattaat agtaatcaat      180

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      240

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      300

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      360

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtccgcccc ctattgacgt      420

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttac gggactttcc      480

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca      540

gtacaccaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat      600

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa      660

taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      720

cagagctcgt ttagtgaacc gagttgttga tctgtgtgaa tcagactgcg acagttcgag      780

tttgaagcga aagctagcaa cagtatcaac aggttttatt ttggatttgg aaacgagagt      840

ttctggtcat gaaaaaccca aaaaagaaat ccggaggatt ccggattgtc aatatgctaa      900

aacgcggagt agcccgtgtg agccgtacga gtgggctgaa cacaaagaat ggatctattt      960

cccttatgtg cttggcctta gggggagtgt tgatcttctt atccacagcc gtctctgctg     1020

atgtggggtg ctcggtggac ttctcaaaga aggagacgag atgcggtacc ggggtgttcg     1080

tctataacga cgttgaagcc tggagggaca ggtacaagta ccatcctgac tccccccgta     1140

gattggcagc agcagtcaag caagcctggg aagatggtat ctgcgggatc tcctctgttt     1200

caagaatgga aaacatcatg tggagatcag tagaagggga gctcaacgca atcctggaag     1260

agaatggagt tcaactgacg gtcgttgtgg gatctgtaaa aaaccccatg gggagaggtc     1320

cacagagatt gcccgtgcct gtgaacgagc tgccccacgg ctggaaggct tgggggaaat     1380

cgtatttcgt cagagcagca aagacaaata acagctttgt cgtggatggt gacacactga     1440

aggaatgccc actcaaacat agagcatgga acagctttct tgtggaggat catgggttcg     1500

gggtatttca cactagtgtc tggctcaagg ttagagaaga ttattcatta gagtgtgatc     1560

cagccgttat tggaacagct gttaagggaa aggaggctgt acacagtgat ctaggctact     1620

ggattgagag tgagaagaat gacacatgga ggctgaagag ggcccatctg atcgagatga     1680

aaacatgtga atggccaaag tcccacacat tgtggacaga tggaatagaa gagagtgatc     1740

tgatcatacc caagtcttta gctgggccac tcagccatca caataccaga gagggctaca     1800

ggacccaaat gaaagggcca tggcacagtg aagagcttga aattcggttt gaggaatgcc     1860

caggcactaa ggtccacgtg gaggaaacat gtggaacaag aggaccatct ctgagatcaa     1920

ccactgcaag cggaagggtg atcgaggaat ggtgctgcag ggagtgcaca atgcccccac     1980

tgtcgttccg ggctaaagat ggctgttggt atggaatgga gataaggccc aggaaagaac     2040

cagaaagcaa cttagtaagg tcaatggtga ctgcaggatc aactgatcac atggaccact     2100

tctcccttgg agtgcttgtg atcctgctca tggtgcagga agggctgaag aagagaatga     2160

ccacaaagat catcataagc acatcaatgg cagtgctggt agctatgatc ctgggaggat     2220

tttcaatgag tgacctggct aagcttgcaa ttttgatggg tgccaccttc gcggaaatga     2280

acactggagg agatgtagct catctggcgc tgatagcggc attcaaagtc agaccagcgt     2340

tgctggtatc tttcatcttc agagctaatt ggacaccccg tgaaagcatg ctgctggcct     2400

tggcctcgtg tcttttgcaa actgcgatct ccgccttgga aggcgacctg atggttctca     2460

tcaatggttt tgctttggcc tggttggcaa tacgagcgat ggttgttcca cgcactgata     2520

acatcacctt ggcaatcctg gctgctctga caccactggc ccggggcaca ctgcttgtgg     2580

cgtggagagc aggccttgct acttgcgggg ggtttatgct cctctctctg aagggaaaag     2640

gcagtgtgaa gaagaactta ccatttgtca tggccctggg actaaccgct gtgaggctgg     2700

tcgaccccat caacgtggtg ggactgctgt tgctcacaag gagtgggaag cggagctggc     2760

cccctagcga agtactcaca gctgttggcc tgatatgcgc attggctgga gggttcgcca     2820

aggcagatat agagatggct gggcccatgg ccgcggtcgg tctgctaatt gtcagttacg     2880

tggtctcagg aaagagtgtg gacatgtaca ttgaaagagc aggtgacatc acatgggaaa     2940

aagatgcgga agtcactgga aacagtcccc ggctcgatgt ggcgctagat gagagtggtg     3000

atttctccct ggtggaggat gacggtcccc ccatgagaga gatcatactc aaggtggtcc     3060

tgatgaccat ctgtggcatg aacccaatag ccataccctt tgcagctgga gcgtggtacg     3120

tatacgtgaa gactggaaaa aggagtggtg ctctatggga tgtgcctgct cccaaggaag     3180

taaaaaaggg ggagaccaca gatggagtgt acagagtaat gacgcgtaga ctgctaggtt     3240

caacacaagt tggagtggga gttatgcaag agggggtctt tcacactatg tggcacgtca     3300

caaaaggatc cgcgctgaga agcggtgaag ggagacttga tccatactgg ggagatgtca     3360

agcaggatct ggtgtcatac tgtggtccat ggaagctaga tgccgcctgg gatgggcaca     3420

gcgaggtgca gctcttggcc gtgccccccg gagagagagc gaggaacatc cagactctgc     3480

ccggaatatt taagacaaag gatggggaca ttggagcggt tgcgctggat tacccagcag     3540

gaacttcagg atctccaatc ctagacaagt gtgggagagt gataggactt tatggcaatg     3600

gggtcgtgat caaaaacggg agttatgtta gtgccatcac ccaagggagg agggaggaag     3660

agactcctgt tgagtgcttc gagccctcga tgctgaagaa gaagcagcta actgtcttag     3720

acttgcatcc tggagctggg aaaaccagga gagttcttcc tgaaatagtc cgtgaagcca     3780

taaaaacaag actccgtact gtgatcttag ctccaaccag ggttgtcgct gctgaaatgg     3840

aggaggccct tagagggctt ccagtgcgtt atatgacaac agcagtcaat gtcacccact     3900

ctggaacaga aatcgtcgac ttaatgtgcc atgccacctt cacttcacgt ctactacagc     3960

caatcagagt ccccaactat aatctgtata ttatggatga ggcccacttc acagatccct     4020

caagtatagc agcaagagga tacatttcaa caagggttga gatgggcgag gcggctgcca     4080

tcttcatgac cgccacgcca ccaggaaccc gtgacgcatt tccggactcc aactcaccaa     4140

ttatggacac cgaagtggaa gtcccagaga gagcctggag ctcaggcttt gattgggtga     4200

cggatcattc tggaaaaaca gtttggtttg ttccaagcgt gaggaacggc aatgagatcg     4260

cagcttgtct gacaaaggct ggaaaacggg tcatacagct cagcagaaag acttttgaga     4320

cagagttcca gaaaacaaaa catcaagagt gggactttgt cgtgacaact gacatttcag     4380

agatgggcgc caactttaaa gctgaccgtg tcatagattc caggagatgc ctaaagccgg     4440

tcatacttga tggcgagaga gtcattctgg ctggacccat gcctgtcaca catgccagcg     4500

ctgcccagag gagggggcgc ataggcagga atcccaacaa acctggagat gagtatctgt     4560

atggaggtgg gtgcgcagag actgacgaag accatgcaca ctggcttgaa gcaagaatgc     4620

tccttgacaa tatttacctc caagatggcc tcatagcctc gctctatcga cctgaggccg     4680

acaaagtagc agccattgag ggagagttca agcttaggac ggagcaaagg aagacctttg     4740

tggaactcat gaaaagagga gatcttcctg tttggctggc ctatcaggtt gcatctgccg     4800

gaataaccta cacagataga agatggtgct ttgatggcac gaccaacaac accataatgg     4860

aagacagtgt gccggcagag gtgtggacca gacacggaga gaaaagagtg ctcaaaccga     4920

ggtggatgga cgccagagtt tgttcagatc atgcggccct gaagtcattc aaggagtttg     4980

ccgctgggaa aagaggagcg gcttttggag tgatggaagc cctgggaaca ctgccaggac     5040

acatgacaga gagattccag gaagccattg acaacctcgc tgtgctcatg cgggcagaga     5100

ctggaagcag gccttacaaa gccgcggcgg cccaattgcc ggagacccta gagaccataa     5160

tgcttttggg gttgctggga acagtctcgc tgggaatctt cttcgtcttg atgaggaaca     5220

agggcatagg gaagatgggc tttggaatgg tgactcttgg ggccagcgca tggctcatgt     5280

ggctctcgga aattgagcca gccagaattg catgtgtcct cattgttgtg ttcctattgc     5340

tggtggtgct catacctgag ccagaaaagc aaagatctcc ccaggacaac caaatggcaa     5400

tcatcatcat ggtagcagta ggtcttctgg gcttgattac cgccaatgaa ctcggatggt     5460

tggagagaac aaagagtgac ctaagccatc taatgggaag gagagaggag ggggcaacca     5520

taggattctc aatggacatt gacctgcggc cagcctcagc ttgggccatc tatgctgcct     5580

tgacaacttt cattacccca gccgtccaac atgcagtgac cacctcatac aacaactact     5640

ccttaatggc gatggccacg caagctggag tgttgtttgg catgggcaaa gggatgccat     5700

tctacgcatg ggactttgga gtcccgctgc taatgatagg ttgctactca caattaacac     5760

ccctgaccct aatagtggcc atcattttgc tcgtggcgca ctacatgtac ttgatcccag     5820

gcctgcaggc agcagctgcg cgtgctgccc agaagagaac ggcagctggc atcatgaaga     5880

accctgttgt ggatggaata gtggtgactg acattgacac aatgacaatt gacccccaag     5940

tggagaaaaa gatgggacag gtgctactca tagcagtagc cgtctccagc gccatactgt     6000

cgcggaccgc ctgggggtgg ggggaggctg gggctctgat cacagccgca acttccactt     6060

tgtgggaagg ctctccgaac aagtactgga actcctctac agccacttca ctgtgtaaca     6120

tttttagggg aagttacttg gctggagctt ctctaatcta cacagtaaca agaaacgctg     6180

gcttggtcaa gagacgtggg ggtggaacag gagagaccct gggagagaaa tggaaggccc     6240

gcttgaacca gatgtcggcc ctggagttct actcctacaa aaagtcaggc atcaccgagg     6300

tgtgcagaga agaggcccgc cgcgccctca aggacggtgt ggcaacggga ggccatgctg     6360

tgtcccgagg aagtgcaaag ctgagatggt tggtggagcg gggatacctg cagccctatg     6420

gaaaggtcat tgatcttgga tgtggcagag ggggctggag ttactacgtc gccaccatcc     6480

gcaaagttca agaagtgaaa ggatacacaa aaggaggccc tggtcatgaa gaacccgtgt     6540

tggtgcaaag ctatgggtgg aacatagtcc gtcttaagag tggggtggac gtctttcata     6600

tggcggctga gccgtgtgac acgttgctgt gtgacatagg tgagtcatca tctagtcctg     6660

aagtggaaga agcacggacg ctcagagtcc tctccatggt gggggattgg cttgaaaaaa     6720

gaccaggagc cttttgtata aaagtgttgt gcccatacac cagcactatg atggaaaccc     6780

tggagcgact gcagcgtagg tatgggggag gactggtcag agtgccactc tcccgcaact     6840

ctacacatga gatgtactgg gtctctggag cgaaaagcaa caccataaaa agtgtgtcca     6900

ccacgagcca gctcctcttg gggcgcatgg acgggcctag gaggccagtg aaatatgagg     6960

aggatgtgaa tctcggctct ggcacgcggg ctgtggtaag ctgcgctgaa gctcccaaca     7020

tgaagatcat tggtaaccgc attgaaagga tccgcagtga gcacgcggaa acgtggttct     7080

ttgacgagaa ccacccatat aggacatggg cttaccatgg aagctatgag gcccccacac     7140

aagggtcagc gtcctctcta ataaacgggg ttgtcaggct cctgtcaaaa ccctgggatg     7200

tggtgactgg agtcacagga atagccatga ccgacaccac accgtatggt cagcaaagag     7260

ttttcaagga aaaagtggac actagggtgc cagaccccca agaaggcact cgtcaggtta     7320

tgagcatggt ctcttcctgg ttgtggaaag agctaggcaa acacaaacgg ccacgagtct     7380

gcaccaaaga agagttcatc aacaaggttc gtagcaatgc agcattaggg gcaatatttg     7440

aagaggaaaa agagtggaag actgcagtgg aagctgtgaa cgatccaagg ttctgggctc     7500

tagtggacaa ggaaagagag caccacctga gaggagagtg ccagagctgt gtgtacaaca     7560

tgatgggaaa aagagaaaag aaacaagggg aatttggaaa ggccaagggc agccgcgcca     7620

tctggtatat gtggctaggg gctagatttc tagagtttga agcccttgga ttcttgaacg     7680

aggatcactg gatggggaga gagaactcag gaggtggtgt tgaagggctg ggattacaaa     7740

gactcggata tgtcctagaa gagatgagtc gtataccagg aggaaggatg tatgcagatg     7800

acactgctgg ctgggacacc cgcattagca ggtttgatct ggagaatgaa gctctaatca     7860

ccaaccaaat ggagaaaggg cacagggcct tggcattggc cataatcaag tacacatacc     7920

aaaacaaagt ggtaaaggtc cttagaccag ctgaaaaagg gaaaacagtt atggacatta     7980

tttcgagaca agaccaaagg gggagcggac aagttgtcac ttacgctctt aacacattta     8040

ccaacctagt ggtgcaactc attcggaata tggaggctga ggaagttcta gagatgcaag     8100

acttgtggct gctgcggagg tcagagaaag tgaccaactg gttgcagagc aacggatggg     8160

ataggctcaa acgaatggca gtcagtggag atgattgcgt tgtgaagcca attgatgata     8220

ggtttgcaca tgccctcagg ttcttgaatg atatgggaaa agttaggaag gacacacaag     8280

agtggaaacc ctcaactgga tgggacaact gggaagaagt tccgttttgc tcccaccact     8340

tcaacaagct ccatctcaag gacgggaggt ccattgtggt tccctgccgc caccaagatg     8400

aactgattgg ccgggcccgc gtctctccag gggcgggatg gagcatccgg gagactgctt     8460

gcctagcaaa atcatatgcg caaatgtggc agctccttta tttccacaga agggacctcc     8520

gactgatggc caatgccatt tgttcatctg tgccagttga ctgggttcca actgggagaa     8580

ctacctggtc aatccatgga aagggagaat ggatgaccac tgaagacatg cttgtggtgt     8640

ggaacagagt gtggattgag gagaacgacc acatggaaga caagacccca gttacgaaat     8700

ggacagacat tccctatttg ggaaaaaggg aagacttgtg gtgtggatct ctcatagggc     8760

acagaccgcg caccacctgg gctgagaaca ttaaaaacac agtcaacatg gtgcgcagga     8820

tcataggtga tgaagaaaag tacatggact acctatccac ccaagttcgc tacttgggtg     8880

aagaagggtc tacacctgga gtgctgtaag caccaatctt aatgttgtca ggcctgctag     8940

tcagccacag cttggggaaa gctgtgcagc ctgtgacccc cccaggagaa gctgggaaac     9000

caagcctata gtcaggccga gaacgccatg gcacggaaga agccatgctg cctgtgagcc     9060

cctcagagga cactgagtca aaaaacccca cgcgcttgga ggcgcaggat gggaaaagaa     9120

ggtggcgacc ttccccaccc ttcaatctgg ggcctgaact ggagatcagc tgtggatctc     9180

cagaagaggg actagtggtt agaggagacc ccccggaaaa cgcaaaacag catattgacg     9240

ctgggaaaga ccagagactc catgagtttc caccacgctg gccgccaggc acagatcgcc     9300

gaatagcggc ggccggtgtg gggaaatcca tgggtctggg tcggcatggc atctccacct     9360

cctcgcggtc cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga     9420

gttcgaatct catgtttgac agcttattaa ttaagactcg cgacagacat gataagatac     9480

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa     9540

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     9600

aacaattgca ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc     9660

aagtaaaacc tctacaaatg tgtcatcgat aagctttaat gcggtagttt atcacagtta     9720

aattgctaac gcagtcaggc accgtgtatg aaatctaaca atgcgctcat cgtcatcctc     9780

ggcaccgtca ccctggatgc tgtaggcata ggcttggtta tgccggtact gccgggcctc     9840

ttgcgggata tcgtccattc cgacagcatc gccagtcact atggcgtgct gctagcgcta     9900

tatgcgttga tgcaatttct atgcgcaccc gttctcggag cactgtccga ccgctttggc     9960

cgccgcccag tcctgctcgc ttcgctactt ggagccacta tcgactacgc gatcatggcg    10020

accacacccg tcctgtggat cctctacgcc ggacgcatcg tggccggcat caccggcgcc    10080

acaggtgcgg ttgctggcgc ctatatcgcc gacatcaccg atggggaaga tcgggctcgc    10140

cacttcgggc tcatgagcgc ttgtttcggc gtgggtatgg tggcaggccc cgtggccggg    10200

ggactgttgg gcgccatctc cttgcatgca ccattccttg cggcggcggt gctcaacggc    10260

ctcaacctac tactgggctg cttcctaatg caggagtcgc ataagggaga gcgtcgaccg    10320

atgcccttga gagccttcaa cccagtcagc tccttccggt gggcgcgggg catgactatc    10380

gtcgccgcac ttatgactgt cttctttatc atgcaactcg taggacaggt gccggcagcg    10440

ctctgggtca ttttcggcga ggaccgcttt cgctggagcg cgacgatgat cggcctgtcg    10500

cttgcggtat tcggaatctt gcacgccctc gctcaagcct tcgtcactgg tcccgccacc    10560

aaacgtttcg gcgagaagca ggccattatc gccggcatgg cggccgacgc gctgggctac    10620

gtcttgctgg cgttcgcgac gcgaggctgg atggccttcc ccattatgat tcttctcgct    10680

tccggcggca tcgggatgcc cgcgttgcag gccatgctgt ccaggcaggt agatgacgac    10740

catcagggac agcttcaagg atcgctcgcg gctcttacca gcctaacttc gatcactgga    10800

ccgctgatcg tcacggcgat ttatgccgcc tcggcgagca catggaacgg gttggcatgg    10860

attgtaggcg ccgccctata ccttgtctgc ctccccgcgt tgcgtcgcgg tgcatggagc    10920

cgggccacct cgacctgaat ggaagccggc ggcacctcgc taacggattc accactccaa    10980

gaattggagc caatcaattc ttgcggagaa ctgtgaatgc gcaaaccaac ccttggcaga    11040

acatatccat cgcgtccgcc atctccagca gccgcacgcg gcgcatctcg ggcagcgttg    11100

ggtcctggcc acgggtgcgc atgatcgtgc tcctgtcgtt gaggacccgg ctaggctggc    11160

ggggttgcct tactggttag cagaatgaat caccgatacg cgagcgaacg tgaagcgact    11220

gctgctgcaa aacgtctgcg acctgagcaa caacatgaat ggtcttcggt ttccgtgttt    11280

cgtaaagtct ggaaacgcgg aagtcagcgc cctgcaccat tatgttccgg atctgcatcg    11340

caggatgctg ctggctaccc tgtggaacac ctacatctgt attaacgaag cgctggcatt    11400

gaccctgagt gatttttctc tggtcccgcc gcatccatac cgccagttgt ttaccctcac    11460

aacgttccag taaccgggca tgttcatcat cagtaacccg tatcgtgagc atcctctctc    11520

gtttcatcgg tatcattacc cccatgaaca gaaatccccc ttacacggag gcatcagtga    11580

ccaaacagga aaaaaccgcc cttaacatgg cccgctttat cagaagccag acattaacgc    11640

ttctggagaa actcaacgag ctggacgcgg atgaacaggc agacatctgt gaatcgcttc    11700

acgaccacgc tgatgagctt taccgcagct gcctcgcgcg tttcggtgat gacggtgaaa    11760

acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga    11820

gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc gcagccatga    11880

cccagtcacg tagcgatagc ggagtgtata ctggcttaac tatgcggcat cagagcagat    11940

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata    12000

ccgcatcagg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct    12060

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga    12120

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc    12180

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg    12240

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg    12300

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt    12360

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt    12420

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg    12480

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact    12540

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt    12600

cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct    12660

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac    12720

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc    12780

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg    12840

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta    12900

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca    12960

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc    13020

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc    13080

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc    13140

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat    13200

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt    13260

tgccattgct gcaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc    13320

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag    13380

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt    13440

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac    13500

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg    13560

cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat    13620

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc    13680

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc    13740

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa    13800

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg    13860

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg    13920

cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac    13980

ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa                          14020


<210>  8
<211>  8947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-CCL5 construct

<400>  8
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcatgaaggt ctccgcggca gccctcgctg tcatcctcat tgctactgcc ctctgcgctc      240

ctgcatctgc ctccccatat tcctcggaca ccacaccctg ctgctttgcc tacattgccc      300

gcccactgcc ccgtgcccac atcaaggagt atttctacac cagtggcaag tgctccaacc      360

cagcagtcgt ctttgtcacc cgaaagaacc gccaagtgtg tgccaaccca gagaagaaat      420

gggttcggga gtacatcaac tctttggaga tgagcagtgg gggctccggc gtgaaacaga      480

ctttgaattt tgaccttctc aagttggccg gagacgtcga gtccaaccct gggcccgcgg      540

ccgccctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt      600

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga      660

aggagacgag atgcggtacc ggggtgttcg tctataacga cgttgaagcc tggagggaca      720

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg      780

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag      840

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg      900

gatctgtaaa aaaccccatg gggagaggtc cacagagatt gcccgtgcct gtgaacgagc      960

tgccccacgg ctggaaggct tgggggaaat cgtatttcgt cagagcagca aagacaaata     1020

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     1080

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     1140

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     1200

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     1260

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     1320

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     1380

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     1440

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     1500

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     1560

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     1620

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     1680

ctgcaggatc aactgatcac atggaccact tctcccttgg agtgcttgtg atcctgctca     1740

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     1800

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     1860

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     1920

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     1980

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     2040

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     2100

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     2160

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     2220

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     2280

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     2340

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     2400

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     2460

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     2520

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     2580

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     2640

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     2700

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     2760

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     2820

acagagtaat gacgcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     2880

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     2940

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     3000

ggaagctaga tgccgcctgg gatgggcaca gcgaggtgca gctcttggcc gtgccccccg     3060

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     3120

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     3180

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaacggg agttatgtta     3240

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccctcga     3300

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     3360

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     3420

ctccaaccag ggttgtcgct gctgaaatgg aggaggccct tagagggctt ccagtgcgtt     3480

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     3540

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     3600

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     3660

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     3720

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     3780

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     3840

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     3900

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     3960

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     4020

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     4080

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     4140

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     4200

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     4260

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     4320

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     4380

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     4440

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     4500

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     4560

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     4620

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     4680

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     4740

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     4800

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     4860

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     4920

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     4980

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     5040

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     5100

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     5160

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     5220

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     5280

tgttgtttgg catgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     5340

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     5400

tcgtggcgca ctacatgtac ttgatcccag gcctgcaggc agcagctgcg cgtgctgccc     5460

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     5520

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     5580

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     5640

gggctctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     5700

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     5760

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     5820

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     5880

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     5940

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     6000

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     6060

ggggctggag ttactacgtc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     6120

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     6180

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     6240

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     6300

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     6360

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     6420

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     6480

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     6540

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     6600

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     6660

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     6720

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     6780

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     6840

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     6900

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     6960

agctaggcaa acacaaacgg ccacgagtct gcaccaaaga agagttcatc aacaaggttc     7020

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     7080

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     7140

gaggagagtg ccagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     7200

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     7260

tagagtttga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     7320

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     7380

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     7440

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     7500

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     7560

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     7620

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     7680

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     7740

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     7800

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     7860

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     7920

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     7980

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     8040

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     8100

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg     8160

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat     8220

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc     8280

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg     8340

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca     8400

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact     8460

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag     8520

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc     8580

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg     8640

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca     8700

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg     8760

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc     8820

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc     8880

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca     8940

tgggtct                                                               8947


<210>  9
<211>  9253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-IL18 construct

<400>  9
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcatggctgc tgaaccagta gaagacaatt gcatcaactt tgtggcaatg aaatttattg      240

acaatacgct ttactttata gctgaagatg atgaaaacct ggaatcagat tactttggca      300

agcttgaatc taaattatca gtcataagaa atttgaatga ccaagttctc ttcattgacc      360

aaggaaatcg gcctctattt gaagatatga ctgattctga ctgtagagat aatgcacccc      420

ggaccatatt tattataagt atgtataaag atagccagcc tagaggtatg gctgtaacta      480

tctctgtgaa gtgtgagaaa atttcaactc tctcctgtga gaacaaaatt atttccttta      540

aggaaatgaa tcctcctgat aacatcaagg atacaaaaag tgacatcata ttctttcaga      600

gaagtgtccc aggacatgat aataagatgc aatttgaatc ttcatcatac gaaggatact      660

ttctagcttg tgaaaaagag agagaccttt ttaaactcat tttgaaaaaa gaggatgaat      720

tgggggatag atctataatg ttcactgttc aaaacgaaga cagtgggggc tccggcgtga      780

aacagacttt gaattttgac cttctcaagt tggccggaga cgtcgagtcc aaccctgggc      840

ccgcggccgc cctgaacaca aagaatggat ctatttccct tatgtgcttg gccttagggg      900

gagtgttgat cttcttatcc acagccgtct ctgctgatgt ggggtgctcg gtggacttct      960

caaagaagga gacgagatgc ggtaccgggg tgttcgtcta taacgacgtt gaagcctgga     1020

gggacaggta caagtaccat cctgactccc cccgtagatt ggcagcagca gtcaagcaag     1080

cctgggaaga tggtatctgc gggatctcct ctgtttcaag aatggaaaac atcatgtgga     1140

gatcagtaga aggggagctc aacgcaatcc tggaagagaa tggagttcaa ctgacggtcg     1200

ttgtgggatc tgtaaaaaac cccatgggga gaggtccaca gagattgccc gtgcctgtga     1260

acgagctgcc ccacggctgg aaggcttggg ggaaatcgta tttcgtcaga gcagcaaaga     1320

caaataacag ctttgtcgtg gatggtgaca cactgaagga atgcccactc aaacatagag     1380

catggaacag ctttcttgtg gaggatcatg ggttcggggt atttcacact agtgtctggc     1440

tcaaggttag agaagattat tcattagagt gtgatccagc cgttattgga acagctgtta     1500

agggaaagga ggctgtacac agtgatctag gctactggat tgagagtgag aagaatgaca     1560

catggaggct gaagagggcc catctgatcg agatgaaaac atgtgaatgg ccaaagtccc     1620

acacattgtg gacagatgga atagaagaga gtgatctgat catacccaag tctttagctg     1680

ggccactcag ccatcacaat accagagagg gctacaggac ccaaatgaaa gggccatggc     1740

acagtgaaga gcttgaaatt cggtttgagg aatgcccagg cactaaggtc cacgtggagg     1800

aaacatgtgg aacaagagga ccatctctga gatcaaccac tgcaagcgga agggtgatcg     1860

aggaatggtg ctgcagggag tgcacaatgc ccccactgtc gttccgggct aaagatggct     1920

gttggtatgg aatggagata aggcccagga aagaaccaga aagcaactta gtaaggtcaa     1980

tggtgactgc aggatcaact gatcacatgg accacttctc ccttggagtg cttgtgatcc     2040

tgctcatggt gcaggaaggg ctgaagaaga gaatgaccac aaagatcatc ataagcacat     2100

caatggcagt gctggtagct atgatcctgg gaggattttc aatgagtgac ctggctaagc     2160

ttgcaatttt gatgggtgcc accttcgcgg aaatgaacac tggaggagat gtagctcatc     2220

tggcgctgat agcggcattc aaagtcagac cagcgttgct ggtatctttc atcttcagag     2280

ctaattggac accccgtgaa agcatgctgc tggccttggc ctcgtgtctt ttgcaaactg     2340

cgatctccgc cttggaaggc gacctgatgg ttctcatcaa tggttttgct ttggcctggt     2400

tggcaatacg agcgatggtt gttccacgca ctgataacat caccttggca atcctggctg     2460

ctctgacacc actggcccgg ggcacactgc ttgtggcgtg gagagcaggc cttgctactt     2520

gcggggggtt tatgctcctc tctctgaagg gaaaaggcag tgtgaagaag aacttaccat     2580

ttgtcatggc cctgggacta accgctgtga ggctggtcga ccccatcaac gtggtgggac     2640

tgctgttgct cacaaggagt gggaagcgga gctggccccc tagcgaagta ctcacagctg     2700

ttggcctgat atgcgcattg gctggagggt tcgccaaggc agatatagag atggctgggc     2760

ccatggccgc ggtcggtctg ctaattgtca gttacgtggt ctcaggaaag agtgtggaca     2820

tgtacattga aagagcaggt gacatcacat gggaaaaaga tgcggaagtc actggaaaca     2880

gtccccggct cgatgtggcg ctagatgaga gtggtgattt ctccctggtg gaggatgacg     2940

gtccccccat gagagagatc atactcaagg tggtcctgat gaccatctgt ggcatgaacc     3000

caatagccat accctttgca gctggagcgt ggtacgtata cgtgaagact ggaaaaagga     3060

gtggtgctct atgggatgtg cctgctccca aggaagtaaa aaagggggag accacagatg     3120

gagtgtacag agtaatgacg cgtagactgc taggttcaac acaagttgga gtgggagtta     3180

tgcaagaggg ggtctttcac actatgtggc acgtcacaaa aggatccgcg ctgagaagcg     3240

gtgaagggag acttgatcca tactggggag atgtcaagca ggatctggtg tcatactgtg     3300

gtccatggaa gctagatgcc gcctgggatg ggcacagcga ggtgcagctc ttggccgtgc     3360

cccccggaga gagagcgagg aacatccaga ctctgcccgg aatatttaag acaaaggatg     3420

gggacattgg agcggttgcg ctggattacc cagcaggaac ttcaggatct ccaatcctag     3480

acaagtgtgg gagagtgata ggactttatg gcaatggggt cgtgatcaaa aacgggagtt     3540

atgttagtgc catcacccaa gggaggaggg aggaagagac tcctgttgag tgcttcgagc     3600

cctcgatgct gaagaagaag cagctaactg tcttagactt gcatcctgga gctgggaaaa     3660

ccaggagagt tcttcctgaa atagtccgtg aagccataaa aacaagactc cgtactgtga     3720

tcttagctcc aaccagggtt gtcgctgctg aaatggagga ggcccttaga gggcttccag     3780

tgcgttatat gacaacagca gtcaatgtca cccactctgg aacagaaatc gtcgacttaa     3840

tgtgccatgc caccttcact tcacgtctac tacagccaat cagagtcccc aactataatc     3900

tgtatattat ggatgaggcc cacttcacag atccctcaag tatagcagca agaggataca     3960

tttcaacaag ggttgagatg ggcgaggcgg ctgccatctt catgaccgcc acgccaccag     4020

gaacccgtga cgcatttccg gactccaact caccaattat ggacaccgaa gtggaagtcc     4080

cagagagagc ctggagctca ggctttgatt gggtgacgga tcattctgga aaaacagttt     4140

ggtttgttcc aagcgtgagg aacggcaatg agatcgcagc ttgtctgaca aaggctggaa     4200

aacgggtcat acagctcagc agaaagactt ttgagacaga gttccagaaa acaaaacatc     4260

aagagtggga ctttgtcgtg acaactgaca tttcagagat gggcgccaac tttaaagctg     4320

accgtgtcat agattccagg agatgcctaa agccggtcat acttgatggc gagagagtca     4380

ttctggctgg acccatgcct gtcacacatg ccagcgctgc ccagaggagg gggcgcatag     4440

gcaggaatcc caacaaacct ggagatgagt atctgtatgg aggtgggtgc gcagagactg     4500

acgaagacca tgcacactgg cttgaagcaa gaatgctcct tgacaatatt tacctccaag     4560

atggcctcat agcctcgctc tatcgacctg aggccgacaa agtagcagcc attgagggag     4620

agttcaagct taggacggag caaaggaaga cctttgtgga actcatgaaa agaggagatc     4680

ttcctgtttg gctggcctat caggttgcat ctgccggaat aacctacaca gatagaagat     4740

ggtgctttga tggcacgacc aacaacacca taatggaaga cagtgtgccg gcagaggtgt     4800

ggaccagaca cggagagaaa agagtgctca aaccgaggtg gatggacgcc agagtttgtt     4860

cagatcatgc ggccctgaag tcattcaagg agtttgccgc tgggaaaaga ggagcggctt     4920

ttggagtgat ggaagccctg ggaacactgc caggacacat gacagagaga ttccaggaag     4980

ccattgacaa cctcgctgtg ctcatgcggg cagagactgg aagcaggcct tacaaagccg     5040

cggcggccca attgccggag accctagaga ccataatgct tttggggttg ctgggaacag     5100

tctcgctggg aatcttcttc gtcttgatga ggaacaaggg catagggaag atgggctttg     5160

gaatggtgac tcttggggcc agcgcatggc tcatgtggct ctcggaaatt gagccagcca     5220

gaattgcatg tgtcctcatt gttgtgttcc tattgctggt ggtgctcata cctgagccag     5280

aaaagcaaag atctccccag gacaaccaaa tggcaatcat catcatggta gcagtaggtc     5340

ttctgggctt gattaccgcc aatgaactcg gatggttgga gagaacaaag agtgacctaa     5400

gccatctaat gggaaggaga gaggaggggg caaccatagg attctcaatg gacattgacc     5460

tgcggccagc ctcagcttgg gccatctatg ctgccttgac aactttcatt accccagccg     5520

tccaacatgc agtgaccacc tcatacaaca actactcctt aatggcgatg gccacgcaag     5580

ctggagtgtt gtttggcatg ggcaaaggga tgccattcta cgcatgggac tttggagtcc     5640

cgctgctaat gataggttgc tactcacaat taacacccct gaccctaata gtggccatca     5700

ttttgctcgt ggcgcactac atgtacttga tcccaggcct gcaggcagca gctgcgcgtg     5760

ctgcccagaa gagaacggca gctggcatca tgaagaaccc tgttgtggat ggaatagtgg     5820

tgactgacat tgacacaatg acaattgacc cccaagtgga gaaaaagatg ggacaggtgc     5880

tactcatagc agtagccgtc tccagcgcca tactgtcgcg gaccgcctgg gggtgggggg     5940

aggctggggc tctgatcaca gccgcaactt ccactttgtg ggaaggctct ccgaacaagt     6000

actggaactc ctctacagcc acttcactgt gtaacatttt taggggaagt tacttggctg     6060

gagcttctct aatctacaca gtaacaagaa acgctggctt ggtcaagaga cgtgggggtg     6120

gaacaggaga gaccctggga gagaaatgga aggcccgctt gaaccagatg tcggccctgg     6180

agttctactc ctacaaaaag tcaggcatca ccgaggtgtg cagagaagag gcccgccgcg     6240

ccctcaagga cggtgtggca acgggaggcc atgctgtgtc ccgaggaagt gcaaagctga     6300

gatggttggt ggagcgggga tacctgcagc cctatggaaa ggtcattgat cttggatgtg     6360

gcagaggggg ctggagttac tacgtcgcca ccatccgcaa agttcaagaa gtgaaaggat     6420

acacaaaagg aggccctggt catgaagaac ccgtgttggt gcaaagctat gggtggaaca     6480

tagtccgtct taagagtggg gtggacgtct ttcatatggc ggctgagccg tgtgacacgt     6540

tgctgtgtga cataggtgag tcatcatcta gtcctgaagt ggaagaagca cggacgctca     6600

gagtcctctc catggtgggg gattggcttg aaaaaagacc aggagccttt tgtataaaag     6660

tgttgtgccc atacaccagc actatgatgg aaaccctgga gcgactgcag cgtaggtatg     6720

ggggaggact ggtcagagtg ccactctccc gcaactctac acatgagatg tactgggtct     6780

ctggagcgaa aagcaacacc ataaaaagtg tgtccaccac gagccagctc ctcttggggc     6840

gcatggacgg gcctaggagg ccagtgaaat atgaggagga tgtgaatctc ggctctggca     6900

cgcgggctgt ggtaagctgc gctgaagctc ccaacatgaa gatcattggt aaccgcattg     6960

aaaggatccg cagtgagcac gcggaaacgt ggttctttga cgagaaccac ccatatagga     7020

catgggctta ccatggaagc tatgaggccc ccacacaagg gtcagcgtcc tctctaataa     7080

acggggttgt caggctcctg tcaaaaccct gggatgtggt gactggagtc acaggaatag     7140

ccatgaccga caccacaccg tatggtcagc aaagagtttt caaggaaaaa gtggacacta     7200

gggtgccaga cccccaagaa ggcactcgtc aggttatgag catggtctct tcctggttgt     7260

ggaaagagct aggcaaacac aaacggccac gagtctgcac caaagaagag ttcatcaaca     7320

aggttcgtag caatgcagca ttaggggcaa tatttgaaga ggaaaaagag tggaagactg     7380

cagtggaagc tgtgaacgat ccaaggttct gggctctagt ggacaaggaa agagagcacc     7440

acctgagagg agagtgccag agctgtgtgt acaacatgat gggaaaaaga gaaaagaaac     7500

aaggggaatt tggaaaggcc aagggcagcc gcgccatctg gtatatgtgg ctaggggcta     7560

gatttctaga gtttgaagcc cttggattct tgaacgagga tcactggatg gggagagaga     7620

actcaggagg tggtgttgaa gggctgggat tacaaagact cggatatgtc ctagaagaga     7680

tgagtcgtat accaggagga aggatgtatg cagatgacac tgctggctgg gacacccgca     7740

ttagcaggtt tgatctggag aatgaagctc taatcaccaa ccaaatggag aaagggcaca     7800

gggccttggc attggccata atcaagtaca cataccaaaa caaagtggta aaggtcctta     7860

gaccagctga aaaagggaaa acagttatgg acattatttc gagacaagac caaaggggga     7920

gcggacaagt tgtcacttac gctcttaaca catttaccaa cctagtggtg caactcattc     7980

ggaatatgga ggctgaggaa gttctagaga tgcaagactt gtggctgctg cggaggtcag     8040

agaaagtgac caactggttg cagagcaacg gatgggatag gctcaaacga atggcagtca     8100

gtggagatga ttgcgttgtg aagccaattg atgataggtt tgcacatgcc ctcaggttct     8160

tgaatgatat gggaaaagtt aggaaggaca cacaagagtg gaaaccctca actggatggg     8220

acaactggga agaagttccg ttttgctccc accacttcaa caagctccat ctcaaggacg     8280

ggaggtccat tgtggttccc tgccgccacc aagatgaact gattggccgg gcccgcgtct     8340

ctccaggggc gggatggagc atccgggaga ctgcttgcct agcaaaatca tatgcgcaaa     8400

tgtggcagct cctttatttc cacagaaggg acctccgact gatggccaat gccatttgtt     8460

catctgtgcc agttgactgg gttccaactg ggagaactac ctggtcaatc catggaaagg     8520

gagaatggat gaccactgaa gacatgcttg tggtgtggaa cagagtgtgg attgaggaga     8580

acgaccacat ggaagacaag accccagtta cgaaatggac agacattccc tatttgggaa     8640

aaagggaaga cttgtggtgt ggatctctca tagggcacag accgcgcacc acctgggctg     8700

agaacattaa aaacacagtc aacatggtgc gcaggatcat aggtgatgaa gaaaagtaca     8760

tggactacct atccacccaa gttcgctact tgggtgaaga agggtctaca cctggagtgc     8820

tgtaagcacc aatcttaatg ttgtcaggcc tgctagtcag ccacagcttg gggaaagctg     8880

tgcagcctgt gaccccccca ggagaagctg ggaaaccaag cctatagtca ggccgagaac     8940

gccatggcac ggaagaagcc atgctgcctg tgagcccctc agaggacact gagtcaaaaa     9000

accccacgcg cttggaggcg caggatggga aaagaaggtg gcgaccttcc ccacccttca     9060

atctggggcc tgaactggag atcagctgtg gatctccaga agagggacta gtggttagag     9120

gagacccccc ggaaaacgca aaacagcata ttgacgctgg gaaagaccag agactccatg     9180

agtttccacc acgctggccg ccaggcacag atcgccgaat agcggcggcc ggtgtgggga     9240

aatccatggg tct                                                        9253


<210>  10
<211>  9133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-IL2 construct

<400>  10
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca      240

gtgcacctac ttcaagttct acaaagaaaa cacagctaca actggagcat ttactgctgg      300

atttacagat gattttgaat ggaattaata attacaagaa tcccaaactc accaggatgc      360

tcacatttaa gttttacatg cccaagaagg ccacagaact gaaacatctt cagtgtctag      420

aagaagaact caaacctctg gaggaagtgc taaatttagc tcaaagcaaa aactttcact      480

taagacccag ggacttaatc agcaatatca acgtaatagt tctggaacta aagggatctg      540

aaacaacatt catgtgtgaa tatgctgatg agacagcaac cattgtagaa tttctgaaca      600

gatggattac cttttgtcaa agcatcatct caacactgac tagtgggggc tccggcgtga      660

aacagacttt gaattttgac cttctcaagt tggccggaga cgtcgagtcc aaccctgggc      720

ccgcggccgc cctgaacaca aagaatggat ctatttccct tatgtgcttg gccttagggg      780

gagtgttgat cttcttatcc acagccgtct ctgctgatgt ggggtgctcg gtggacttct      840

caaagaagga gacgagatgc ggtaccgggg tgttcgtcta taacgacgtt gaagcctgga      900

gggacaggta caagtaccat cctgactccc cccgtagatt ggcagcagca gtcaagcaag      960

cctgggaaga tggtatctgc gggatctcct ctgtttcaag aatggaaaac atcatgtgga     1020

gatcagtaga aggggagctc aacgcaatcc tggaagagaa tggagttcaa ctgacggtcg     1080

ttgtgggatc tgtaaaaaac cccatgggga gaggtccaca gagattgccc gtgcctgtga     1140

acgagctgcc ccacggctgg aaggcttggg ggaaatcgta tttcgtcaga gcagcaaaga     1200

caaataacag ctttgtcgtg gatggtgaca cactgaagga atgcccactc aaacatagag     1260

catggaacag ctttcttgtg gaggatcatg ggttcggggt atttcacact agtgtctggc     1320

tcaaggttag agaagattat tcattagagt gtgatccagc cgttattgga acagctgtta     1380

agggaaagga ggctgtacac agtgatctag gctactggat tgagagtgag aagaatgaca     1440

catggaggct gaagagggcc catctgatcg agatgaaaac atgtgaatgg ccaaagtccc     1500

acacattgtg gacagatgga atagaagaga gtgatctgat catacccaag tctttagctg     1560

ggccactcag ccatcacaat accagagagg gctacaggac ccaaatgaaa gggccatggc     1620

acagtgaaga gcttgaaatt cggtttgagg aatgcccagg cactaaggtc cacgtggagg     1680

aaacatgtgg aacaagagga ccatctctga gatcaaccac tgcaagcgga agggtgatcg     1740

aggaatggtg ctgcagggag tgcacaatgc ccccactgtc gttccgggct aaagatggct     1800

gttggtatgg aatggagata aggcccagga aagaaccaga aagcaactta gtaaggtcaa     1860

tggtgactgc aggatcaact gatcacatgg accacttctc ccttggagtg cttgtgatcc     1920

tgctcatggt gcaggaaggg ctgaagaaga gaatgaccac aaagatcatc ataagcacat     1980

caatggcagt gctggtagct atgatcctgg gaggattttc aatgagtgac ctggctaagc     2040

ttgcaatttt gatgggtgcc accttcgcgg aaatgaacac tggaggagat gtagctcatc     2100

tggcgctgat agcggcattc aaagtcagac cagcgttgct ggtatctttc atcttcagag     2160

ctaattggac accccgtgaa agcatgctgc tggccttggc ctcgtgtctt ttgcaaactg     2220

cgatctccgc cttggaaggc gacctgatgg ttctcatcaa tggttttgct ttggcctggt     2280

tggcaatacg agcgatggtt gttccacgca ctgataacat caccttggca atcctggctg     2340

ctctgacacc actggcccgg ggcacactgc ttgtggcgtg gagagcaggc cttgctactt     2400

gcggggggtt tatgctcctc tctctgaagg gaaaaggcag tgtgaagaag aacttaccat     2460

ttgtcatggc cctgggacta accgctgtga ggctggtcga ccccatcaac gtggtgggac     2520

tgctgttgct cacaaggagt gggaagcgga gctggccccc tagcgaagta ctcacagctg     2580

ttggcctgat atgcgcattg gctggagggt tcgccaaggc agatatagag atggctgggc     2640

ccatggccgc ggtcggtctg ctaattgtca gttacgtggt ctcaggaaag agtgtggaca     2700

tgtacattga aagagcaggt gacatcacat gggaaaaaga tgcggaagtc actggaaaca     2760

gtccccggct cgatgtggcg ctagatgaga gtggtgattt ctccctggtg gaggatgacg     2820

gtccccccat gagagagatc atactcaagg tggtcctgat gaccatctgt ggcatgaacc     2880

caatagccat accctttgca gctggagcgt ggtacgtata cgtgaagact ggaaaaagga     2940

gtggtgctct atgggatgtg cctgctccca aggaagtaaa aaagggggag accacagatg     3000

gagtgtacag agtaatgacg cgtagactgc taggttcaac acaagttgga gtgggagtta     3060

tgcaagaggg ggtctttcac actatgtggc acgtcacaaa aggatccgcg ctgagaagcg     3120

gtgaagggag acttgatcca tactggggag atgtcaagca ggatctggtg tcatactgtg     3180

gtccatggaa gctagatgcc gcctgggatg ggcacagcga ggtgcagctc ttggccgtgc     3240

cccccggaga gagagcgagg aacatccaga ctctgcccgg aatatttaag acaaaggatg     3300

gggacattgg agcggttgcg ctggattacc cagcaggaac ttcaggatct ccaatcctag     3360

acaagtgtgg gagagtgata ggactttatg gcaatggggt cgtgatcaaa aacgggagtt     3420

atgttagtgc catcacccaa gggaggaggg aggaagagac tcctgttgag tgcttcgagc     3480

cctcgatgct gaagaagaag cagctaactg tcttagactt gcatcctgga gctgggaaaa     3540

ccaggagagt tcttcctgaa atagtccgtg aagccataaa aacaagactc cgtactgtga     3600

tcttagctcc aaccagggtt gtcgctgctg aaatggagga ggcccttaga gggcttccag     3660

tgcgttatat gacaacagca gtcaatgtca cccactctgg aacagaaatc gtcgacttaa     3720

tgtgccatgc caccttcact tcacgtctac tacagccaat cagagtcccc aactataatc     3780

tgtatattat ggatgaggcc cacttcacag atccctcaag tatagcagca agaggataca     3840

tttcaacaag ggttgagatg ggcgaggcgg ctgccatctt catgaccgcc acgccaccag     3900

gaacccgtga cgcatttccg gactccaact caccaattat ggacaccgaa gtggaagtcc     3960

cagagagagc ctggagctca ggctttgatt gggtgacgga tcattctgga aaaacagttt     4020

ggtttgttcc aagcgtgagg aacggcaatg agatcgcagc ttgtctgaca aaggctggaa     4080

aacgggtcat acagctcagc agaaagactt ttgagacaga gttccagaaa acaaaacatc     4140

aagagtggga ctttgtcgtg acaactgaca tttcagagat gggcgccaac tttaaagctg     4200

accgtgtcat agattccagg agatgcctaa agccggtcat acttgatggc gagagagtca     4260

ttctggctgg acccatgcct gtcacacatg ccagcgctgc ccagaggagg gggcgcatag     4320

gcaggaatcc caacaaacct ggagatgagt atctgtatgg aggtgggtgc gcagagactg     4380

acgaagacca tgcacactgg cttgaagcaa gaatgctcct tgacaatatt tacctccaag     4440

atggcctcat agcctcgctc tatcgacctg aggccgacaa agtagcagcc attgagggag     4500

agttcaagct taggacggag caaaggaaga cctttgtgga actcatgaaa agaggagatc     4560

ttcctgtttg gctggcctat caggttgcat ctgccggaat aacctacaca gatagaagat     4620

ggtgctttga tggcacgacc aacaacacca taatggaaga cagtgtgccg gcagaggtgt     4680

ggaccagaca cggagagaaa agagtgctca aaccgaggtg gatggacgcc agagtttgtt     4740

cagatcatgc ggccctgaag tcattcaagg agtttgccgc tgggaaaaga ggagcggctt     4800

ttggagtgat ggaagccctg ggaacactgc caggacacat gacagagaga ttccaggaag     4860

ccattgacaa cctcgctgtg ctcatgcggg cagagactgg aagcaggcct tacaaagccg     4920

cggcggccca attgccggag accctagaga ccataatgct tttggggttg ctgggaacag     4980

tctcgctggg aatcttcttc gtcttgatga ggaacaaggg catagggaag atgggctttg     5040

gaatggtgac tcttggggcc agcgcatggc tcatgtggct ctcggaaatt gagccagcca     5100

gaattgcatg tgtcctcatt gttgtgttcc tattgctggt ggtgctcata cctgagccag     5160

aaaagcaaag atctccccag gacaaccaaa tggcaatcat catcatggta gcagtaggtc     5220

ttctgggctt gattaccgcc aatgaactcg gatggttgga gagaacaaag agtgacctaa     5280

gccatctaat gggaaggaga gaggaggggg caaccatagg attctcaatg gacattgacc     5340

tgcggccagc ctcagcttgg gccatctatg ctgccttgac aactttcatt accccagccg     5400

tccaacatgc agtgaccacc tcatacaaca actactcctt aatggcgatg gccacgcaag     5460

ctggagtgtt gtttggcatg ggcaaaggga tgccattcta cgcatgggac tttggagtcc     5520

cgctgctaat gataggttgc tactcacaat taacacccct gaccctaata gtggccatca     5580

ttttgctcgt ggcgcactac atgtacttga tcccaggcct gcaggcagca gctgcgcgtg     5640

ctgcccagaa gagaacggca gctggcatca tgaagaaccc tgttgtggat ggaatagtgg     5700

tgactgacat tgacacaatg acaattgacc cccaagtgga gaaaaagatg ggacaggtgc     5760

tactcatagc agtagccgtc tccagcgcca tactgtcgcg gaccgcctgg gggtgggggg     5820

aggctggggc tctgatcaca gccgcaactt ccactttgtg ggaaggctct ccgaacaagt     5880

actggaactc ctctacagcc acttcactgt gtaacatttt taggggaagt tacttggctg     5940

gagcttctct aatctacaca gtaacaagaa acgctggctt ggtcaagaga cgtgggggtg     6000

gaacaggaga gaccctggga gagaaatgga aggcccgctt gaaccagatg tcggccctgg     6060

agttctactc ctacaaaaag tcaggcatca ccgaggtgtg cagagaagag gcccgccgcg     6120

ccctcaagga cggtgtggca acgggaggcc atgctgtgtc ccgaggaagt gcaaagctga     6180

gatggttggt ggagcgggga tacctgcagc cctatggaaa ggtcattgat cttggatgtg     6240

gcagaggggg ctggagttac tacgtcgcca ccatccgcaa agttcaagaa gtgaaaggat     6300

acacaaaagg aggccctggt catgaagaac ccgtgttggt gcaaagctat gggtggaaca     6360

tagtccgtct taagagtggg gtggacgtct ttcatatggc ggctgagccg tgtgacacgt     6420

tgctgtgtga cataggtgag tcatcatcta gtcctgaagt ggaagaagca cggacgctca     6480

gagtcctctc catggtgggg gattggcttg aaaaaagacc aggagccttt tgtataaaag     6540

tgttgtgccc atacaccagc actatgatgg aaaccctgga gcgactgcag cgtaggtatg     6600

ggggaggact ggtcagagtg ccactctccc gcaactctac acatgagatg tactgggtct     6660

ctggagcgaa aagcaacacc ataaaaagtg tgtccaccac gagccagctc ctcttggggc     6720

gcatggacgg gcctaggagg ccagtgaaat atgaggagga tgtgaatctc ggctctggca     6780

cgcgggctgt ggtaagctgc gctgaagctc ccaacatgaa gatcattggt aaccgcattg     6840

aaaggatccg cagtgagcac gcggaaacgt ggttctttga cgagaaccac ccatatagga     6900

catgggctta ccatggaagc tatgaggccc ccacacaagg gtcagcgtcc tctctaataa     6960

acggggttgt caggctcctg tcaaaaccct gggatgtggt gactggagtc acaggaatag     7020

ccatgaccga caccacaccg tatggtcagc aaagagtttt caaggaaaaa gtggacacta     7080

gggtgccaga cccccaagaa ggcactcgtc aggttatgag catggtctct tcctggttgt     7140

ggaaagagct aggcaaacac aaacggccac gagtctgcac caaagaagag ttcatcaaca     7200

aggttcgtag caatgcagca ttaggggcaa tatttgaaga ggaaaaagag tggaagactg     7260

cagtggaagc tgtgaacgat ccaaggttct gggctctagt ggacaaggaa agagagcacc     7320

acctgagagg agagtgccag agctgtgtgt acaacatgat gggaaaaaga gaaaagaaac     7380

aaggggaatt tggaaaggcc aagggcagcc gcgccatctg gtatatgtgg ctaggggcta     7440

gatttctaga gtttgaagcc cttggattct tgaacgagga tcactggatg gggagagaga     7500

actcaggagg tggtgttgaa gggctgggat tacaaagact cggatatgtc ctagaagaga     7560

tgagtcgtat accaggagga aggatgtatg cagatgacac tgctggctgg gacacccgca     7620

ttagcaggtt tgatctggag aatgaagctc taatcaccaa ccaaatggag aaagggcaca     7680

gggccttggc attggccata atcaagtaca cataccaaaa caaagtggta aaggtcctta     7740

gaccagctga aaaagggaaa acagttatgg acattatttc gagacaagac caaaggggga     7800

gcggacaagt tgtcacttac gctcttaaca catttaccaa cctagtggtg caactcattc     7860

ggaatatgga ggctgaggaa gttctagaga tgcaagactt gtggctgctg cggaggtcag     7920

agaaagtgac caactggttg cagagcaacg gatgggatag gctcaaacga atggcagtca     7980

gtggagatga ttgcgttgtg aagccaattg atgataggtt tgcacatgcc ctcaggttct     8040

tgaatgatat gggaaaagtt aggaaggaca cacaagagtg gaaaccctca actggatggg     8100

acaactggga agaagttccg ttttgctccc accacttcaa caagctccat ctcaaggacg     8160

ggaggtccat tgtggttccc tgccgccacc aagatgaact gattggccgg gcccgcgtct     8220

ctccaggggc gggatggagc atccgggaga ctgcttgcct agcaaaatca tatgcgcaaa     8280

tgtggcagct cctttatttc cacagaaggg acctccgact gatggccaat gccatttgtt     8340

catctgtgcc agttgactgg gttccaactg ggagaactac ctggtcaatc catggaaagg     8400

gagaatggat gaccactgaa gacatgcttg tggtgtggaa cagagtgtgg attgaggaga     8460

acgaccacat ggaagacaag accccagtta cgaaatggac agacattccc tatttgggaa     8520

aaagggaaga cttgtggtgt ggatctctca tagggcacag accgcgcacc acctgggctg     8580

agaacattaa aaacacagtc aacatggtgc gcaggatcat aggtgatgaa gaaaagtaca     8640

tggactacct atccacccaa gttcgctact tgggtgaaga agggtctaca cctggagtgc     8700

tgtaagcacc aatcttaatg ttgtcaggcc tgctagtcag ccacagcttg gggaaagctg     8760

tgcagcctgt gaccccccca ggagaagctg ggaaaccaag cctatagtca ggccgagaac     8820

gccatggcac ggaagaagcc atgctgcctg tgagcccctc agaggacact gagtcaaaaa     8880

accccacgcg cttggaggcg caggatggga aaagaaggtg gcgaccttcc ccacccttca     8940

atctggggcc tgaactggag atcagctgtg gatctccaga agagggacta gtggttagag     9000

gagacccccc ggaaaacgca aaacagcata ttgacgctgg gaaagaccag agactccatg     9060

agtttccacc acgctggccg ccaggcacag atcgccgaat agcggcggcc ggtgtgggga     9120

aatccatggg tct                                                        9133


<210>  11
<211>  9394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-TNFSF14 construct

<400>  11
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcatggagga gagtgtcgta cggccctcag tgtttgtggt ggatggacag accgacatcc      240

cattcacgag gctgggacga agccaccgga gacagtcgtg cagtgtggcc cgggtgggtc      300

tgggtctctt gctgttgctg atgggggccg ggctggccgt ccaaggctgg ttcctcctgc      360

agctgcactg gcgtctagga gagatggtca cccgcctgcc tgacggacct gcaggctcct      420

gggagcagct gatacaagag cgaaggtctc acgaggtcaa cccagcagcg catctcacag      480

gggccaactc cagcttgacc ggcagcgggg ggccgctgtt atgggagact cagctgggcc      540

tggccttcct gaggggcctc agctaccacg atggggccct tgtggtcacc aaagctggct      600

actactacat ctactccaag gtgcagctgg gcggtgtggg ctgcccgctg ggcctggcca      660

gcaccatcac ccacggcctc tacaagcgca caccccgcta ccccgaggag ctggagctgt      720

tggtcagcca gcagtcaccc tgcggacggg ccaccagcag ctcccgggtc tggtgggaca      780

gcagcttcct gggtggtgtg gtacacctgg aggctgggga gaaggtggtc gtccgtgtgc      840

tggatgaacg cctggttcga ctgcgtgatg gtacccggtc ttacttcggg gctttcatgg      900

tgagtggggg ctccggcgtg aaacagactt tgaattttga ccttctcaag ttggccggag      960

acgtcgagtc caaccctggg cccgcggccg ccctgaacac aaagaatgga tctatttccc     1020

ttatgtgctt ggccttaggg ggagtgttga tcttcttatc cacagccgtc tctgctgatg     1080

tggggtgctc ggtggacttc tcaaagaagg agacgagatg cggtaccggg gtgttcgtct     1140

ataacgacgt tgaagcctgg agggacaggt acaagtacca tcctgactcc ccccgtagat     1200

tggcagcagc agtcaagcaa gcctgggaag atggtatctg cgggatctcc tctgtttcaa     1260

gaatggaaaa catcatgtgg agatcagtag aaggggagct caacgcaatc ctggaagaga     1320

atggagttca actgacggtc gttgtgggat ctgtaaaaaa ccccatgggg agaggtccac     1380

agagattgcc cgtgcctgtg aacgagctgc cccacggctg gaaggcttgg gggaaatcgt     1440

atttcgtcag agcagcaaag acaaataaca gctttgtcgt ggatggtgac acactgaagg     1500

aatgcccact caaacataga gcatggaaca gctttcttgt ggaggatcat gggttcgggg     1560

tatttcacac tagtgtctgg ctcaaggtta gagaagatta ttcattagag tgtgatccag     1620

ccgttattgg aacagctgtt aagggaaagg aggctgtaca cagtgatcta ggctactgga     1680

ttgagagtga gaagaatgac acatggaggc tgaagagggc ccatctgatc gagatgaaaa     1740

catgtgaatg gccaaagtcc cacacattgt ggacagatgg aatagaagag agtgatctga     1800

tcatacccaa gtctttagct gggccactca gccatcacaa taccagagag ggctacagga     1860

cccaaatgaa agggccatgg cacagtgaag agcttgaaat tcggtttgag gaatgcccag     1920

gcactaaggt ccacgtggag gaaacatgtg gaacaagagg accatctctg agatcaacca     1980

ctgcaagcgg aagggtgatc gaggaatggt gctgcaggga gtgcacaatg cccccactgt     2040

cgttccgggc taaagatggc tgttggtatg gaatggagat aaggcccagg aaagaaccag     2100

aaagcaactt agtaaggtca atggtgactg caggatcaac tgatcacatg gaccacttct     2160

cccttggagt gcttgtgatc ctgctcatgg tgcaggaagg gctgaagaag agaatgacca     2220

caaagatcat cataagcaca tcaatggcag tgctggtagc tatgatcctg ggaggatttt     2280

caatgagtga cctggctaag cttgcaattt tgatgggtgc caccttcgcg gaaatgaaca     2340

ctggaggaga tgtagctcat ctggcgctga tagcggcatt caaagtcaga ccagcgttgc     2400

tggtatcttt catcttcaga gctaattgga caccccgtga aagcatgctg ctggccttgg     2460

cctcgtgtct tttgcaaact gcgatctccg ccttggaagg cgacctgatg gttctcatca     2520

atggttttgc tttggcctgg ttggcaatac gagcgatggt tgttccacgc actgataaca     2580

tcaccttggc aatcctggct gctctgacac cactggcccg gggcacactg cttgtggcgt     2640

ggagagcagg ccttgctact tgcggggggt ttatgctcct ctctctgaag ggaaaaggca     2700

gtgtgaagaa gaacttacca tttgtcatgg ccctgggact aaccgctgtg aggctggtcg     2760

accccatcaa cgtggtggga ctgctgttgc tcacaaggag tgggaagcgg agctggcccc     2820

ctagcgaagt actcacagct gttggcctga tatgcgcatt ggctggaggg ttcgccaagg     2880

cagatataga gatggctggg cccatggccg cggtcggtct gctaattgtc agttacgtgg     2940

tctcaggaaa gagtgtggac atgtacattg aaagagcagg tgacatcaca tgggaaaaag     3000

atgcggaagt cactggaaac agtccccggc tcgatgtggc gctagatgag agtggtgatt     3060

tctccctggt ggaggatgac ggtcccccca tgagagagat catactcaag gtggtcctga     3120

tgaccatctg tggcatgaac ccaatagcca taccctttgc agctggagcg tggtacgtat     3180

acgtgaagac tggaaaaagg agtggtgctc tatgggatgt gcctgctccc aaggaagtaa     3240

aaaaggggga gaccacagat ggagtgtaca gagtaatgac gcgtagactg ctaggttcaa     3300

cacaagttgg agtgggagtt atgcaagagg gggtctttca cactatgtgg cacgtcacaa     3360

aaggatccgc gctgagaagc ggtgaaggga gacttgatcc atactgggga gatgtcaagc     3420

aggatctggt gtcatactgt ggtccatgga agctagatgc cgcctgggat gggcacagcg     3480

aggtgcagct cttggccgtg ccccccggag agagagcgag gaacatccag actctgcccg     3540

gaatatttaa gacaaaggat ggggacattg gagcggttgc gctggattac ccagcaggaa     3600

cttcaggatc tccaatccta gacaagtgtg ggagagtgat aggactttat ggcaatgggg     3660

tcgtgatcaa aaacgggagt tatgttagtg ccatcaccca agggaggagg gaggaagaga     3720

ctcctgttga gtgcttcgag ccctcgatgc tgaagaagaa gcagctaact gtcttagact     3780

tgcatcctgg agctgggaaa accaggagag ttcttcctga aatagtccgt gaagccataa     3840

aaacaagact ccgtactgtg atcttagctc caaccagggt tgtcgctgct gaaatggagg     3900

aggcccttag agggcttcca gtgcgttata tgacaacagc agtcaatgtc acccactctg     3960

gaacagaaat cgtcgactta atgtgccatg ccaccttcac ttcacgtcta ctacagccaa     4020

tcagagtccc caactataat ctgtatatta tggatgaggc ccacttcaca gatccctcaa     4080

gtatagcagc aagaggatac atttcaacaa gggttgagat gggcgaggcg gctgccatct     4140

tcatgaccgc cacgccacca ggaacccgtg acgcatttcc ggactccaac tcaccaatta     4200

tggacaccga agtggaagtc ccagagagag cctggagctc aggctttgat tgggtgacgg     4260

atcattctgg aaaaacagtt tggtttgttc caagcgtgag gaacggcaat gagatcgcag     4320

cttgtctgac aaaggctgga aaacgggtca tacagctcag cagaaagact tttgagacag     4380

agttccagaa aacaaaacat caagagtggg actttgtcgt gacaactgac atttcagaga     4440

tgggcgccaa ctttaaagct gaccgtgtca tagattccag gagatgccta aagccggtca     4500

tacttgatgg cgagagagtc attctggctg gacccatgcc tgtcacacat gccagcgctg     4560

cccagaggag ggggcgcata ggcaggaatc ccaacaaacc tggagatgag tatctgtatg     4620

gaggtgggtg cgcagagact gacgaagacc atgcacactg gcttgaagca agaatgctcc     4680

ttgacaatat ttacctccaa gatggcctca tagcctcgct ctatcgacct gaggccgaca     4740

aagtagcagc cattgaggga gagttcaagc ttaggacgga gcaaaggaag acctttgtgg     4800

aactcatgaa aagaggagat cttcctgttt ggctggccta tcaggttgca tctgccggaa     4860

taacctacac agatagaaga tggtgctttg atggcacgac caacaacacc ataatggaag     4920

acagtgtgcc ggcagaggtg tggaccagac acggagagaa aagagtgctc aaaccgaggt     4980

ggatggacgc cagagtttgt tcagatcatg cggccctgaa gtcattcaag gagtttgccg     5040

ctgggaaaag aggagcggct tttggagtga tggaagccct gggaacactg ccaggacaca     5100

tgacagagag attccaggaa gccattgaca acctcgctgt gctcatgcgg gcagagactg     5160

gaagcaggcc ttacaaagcc gcggcggccc aattgccgga gaccctagag accataatgc     5220

ttttggggtt gctgggaaca gtctcgctgg gaatcttctt cgtcttgatg aggaacaagg     5280

gcatagggaa gatgggcttt ggaatggtga ctcttggggc cagcgcatgg ctcatgtggc     5340

tctcggaaat tgagccagcc agaattgcat gtgtcctcat tgttgtgttc ctattgctgg     5400

tggtgctcat acctgagcca gaaaagcaaa gatctcccca ggacaaccaa atggcaatca     5460

tcatcatggt agcagtaggt cttctgggct tgattaccgc caatgaactc ggatggttgg     5520

agagaacaaa gagtgaccta agccatctaa tgggaaggag agaggagggg gcaaccatag     5580

gattctcaat ggacattgac ctgcggccag cctcagcttg ggccatctat gctgccttga     5640

caactttcat taccccagcc gtccaacatg cagtgaccac ctcatacaac aactactcct     5700

taatggcgat ggccacgcaa gctggagtgt tgtttggcat gggcaaaggg atgccattct     5760

acgcatggga ctttggagtc ccgctgctaa tgataggttg ctactcacaa ttaacacccc     5820

tgaccctaat agtggccatc attttgctcg tggcgcacta catgtacttg atcccaggcc     5880

tgcaggcagc agctgcgcgt gctgcccaga agagaacggc agctggcatc atgaagaacc     5940

ctgttgtgga tggaatagtg gtgactgaca ttgacacaat gacaattgac ccccaagtgg     6000

agaaaaagat gggacaggtg ctactcatag cagtagccgt ctccagcgcc atactgtcgc     6060

ggaccgcctg ggggtggggg gaggctgggg ctctgatcac agccgcaact tccactttgt     6120

gggaaggctc tccgaacaag tactggaact cctctacagc cacttcactg tgtaacattt     6180

ttaggggaag ttacttggct ggagcttctc taatctacac agtaacaaga aacgctggct     6240

tggtcaagag acgtgggggt ggaacaggag agaccctggg agagaaatgg aaggcccgct     6300

tgaaccagat gtcggccctg gagttctact cctacaaaaa gtcaggcatc accgaggtgt     6360

gcagagaaga ggcccgccgc gccctcaagg acggtgtggc aacgggaggc catgctgtgt     6420

cccgaggaag tgcaaagctg agatggttgg tggagcgggg atacctgcag ccctatggaa     6480

aggtcattga tcttggatgt ggcagagggg gctggagtta ctacgtcgcc accatccgca     6540

aagttcaaga agtgaaagga tacacaaaag gaggccctgg tcatgaagaa cccgtgttgg     6600

tgcaaagcta tgggtggaac atagtccgtc ttaagagtgg ggtggacgtc tttcatatgg     6660

cggctgagcc gtgtgacacg ttgctgtgtg acataggtga gtcatcatct agtcctgaag     6720

tggaagaagc acggacgctc agagtcctct ccatggtggg ggattggctt gaaaaaagac     6780

caggagcctt ttgtataaaa gtgttgtgcc catacaccag cactatgatg gaaaccctgg     6840

agcgactgca gcgtaggtat gggggaggac tggtcagagt gccactctcc cgcaactcta     6900

cacatgagat gtactgggtc tctggagcga aaagcaacac cataaaaagt gtgtccacca     6960

cgagccagct cctcttgggg cgcatggacg ggcctaggag gccagtgaaa tatgaggagg     7020

atgtgaatct cggctctggc acgcgggctg tggtaagctg cgctgaagct cccaacatga     7080

agatcattgg taaccgcatt gaaaggatcc gcagtgagca cgcggaaacg tggttctttg     7140

acgagaacca cccatatagg acatgggctt accatggaag ctatgaggcc cccacacaag     7200

ggtcagcgtc ctctctaata aacggggttg tcaggctcct gtcaaaaccc tgggatgtgg     7260

tgactggagt cacaggaata gccatgaccg acaccacacc gtatggtcag caaagagttt     7320

tcaaggaaaa agtggacact agggtgccag acccccaaga aggcactcgt caggttatga     7380

gcatggtctc ttcctggttg tggaaagagc taggcaaaca caaacggcca cgagtctgca     7440

ccaaagaaga gttcatcaac aaggttcgta gcaatgcagc attaggggca atatttgaag     7500

aggaaaaaga gtggaagact gcagtggaag ctgtgaacga tccaaggttc tgggctctag     7560

tggacaagga aagagagcac cacctgagag gagagtgcca gagctgtgtg tacaacatga     7620

tgggaaaaag agaaaagaaa caaggggaat ttggaaaggc caagggcagc cgcgccatct     7680

ggtatatgtg gctaggggct agatttctag agtttgaagc ccttggattc ttgaacgagg     7740

atcactggat ggggagagag aactcaggag gtggtgttga agggctggga ttacaaagac     7800

tcggatatgt cctagaagag atgagtcgta taccaggagg aaggatgtat gcagatgaca     7860

ctgctggctg ggacacccgc attagcaggt ttgatctgga gaatgaagct ctaatcacca     7920

accaaatgga gaaagggcac agggccttgg cattggccat aatcaagtac acataccaaa     7980

acaaagtggt aaaggtcctt agaccagctg aaaaagggaa aacagttatg gacattattt     8040

cgagacaaga ccaaaggggg agcggacaag ttgtcactta cgctcttaac acatttacca     8100

acctagtggt gcaactcatt cggaatatgg aggctgagga agttctagag atgcaagact     8160

tgtggctgct gcggaggtca gagaaagtga ccaactggtt gcagagcaac ggatgggata     8220

ggctcaaacg aatggcagtc agtggagatg attgcgttgt gaagccaatt gatgataggt     8280

ttgcacatgc cctcaggttc ttgaatgata tgggaaaagt taggaaggac acacaagagt     8340

ggaaaccctc aactggatgg gacaactggg aagaagttcc gttttgctcc caccacttca     8400

acaagctcca tctcaaggac gggaggtcca ttgtggttcc ctgccgccac caagatgaac     8460

tgattggccg ggcccgcgtc tctccagggg cgggatggag catccgggag actgcttgcc     8520

tagcaaaatc atatgcgcaa atgtggcagc tcctttattt ccacagaagg gacctccgac     8580

tgatggccaa tgccatttgt tcatctgtgc cagttgactg ggttccaact gggagaacta     8640

cctggtcaat ccatggaaag ggagaatgga tgaccactga agacatgctt gtggtgtgga     8700

acagagtgtg gattgaggag aacgaccaca tggaagacaa gaccccagtt acgaaatgga     8760

cagacattcc ctatttggga aaaagggaag acttgtggtg tggatctctc atagggcaca     8820

gaccgcgcac cacctgggct gagaacatta aaaacacagt caacatggtg cgcaggatca     8880

taggtgatga agaaaagtac atggactacc tatccaccca agttcgctac ttgggtgaag     8940

aagggtctac acctggagtg ctgtaagcac caatcttaat gttgtcaggc ctgctagtca     9000

gccacagctt ggggaaagct gtgcagcctg tgaccccccc aggagaagct gggaaaccaa     9060

gcctatagtc aggccgagaa cgccatggca cggaagaagc catgctgcct gtgagcccct     9120

cagaggacac tgagtcaaaa aaccccacgc gcttggaggc gcaggatggg aaaagaaggt     9180

ggcgaccttc cccacccttc aatctggggc ctgaactgga gatcagctgt ggatctccag     9240

aagagggact agtggttaga ggagaccccc cggaaaacgc aaaacagcat attgacgctg     9300

ggaaagacca gagactccat gagtttccac cacgctggcc gccaggcaca gatcgccgaa     9360

tagcggcggc cggtgtgggg aaatccatgg gtct                                 9394


<210>  12
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VAX2B construct

<400>  12
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaacaata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacca      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagcg gccgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttctgac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttacag     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccga     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cctgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggagttacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtacc ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg gggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtatttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggaccact tctcccttgg agtgcttgtg atcctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gacgcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gatgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaacggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccctcga     5160

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaggccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg catgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag gcctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggctctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgtc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gcaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  13
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BsiWI linker

<400>  13
cgtacgagtg gg                                                           12


<210>  14
<211>  14821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VAXR1 construct

<400>  14
gaattctcaa tattggccat tagccatatt attcattggt tatatagcat aaatcaatat       60

tggctattgg ccattgcata cgttgtatct atatcataat atgtacattt atattggctc      120

atgtccaata tgaccgccat gttggcattg attattgact agttattaat agtaatcaat      180

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      240

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      300

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      360

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtccgcccc ctattgacgt      420

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttac gggactttcc      480

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca      540

gtacaccaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat      600

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa      660

taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      720

cagagctcgt ttagtgaacc gagttgttga tctgtgtgaa tcagactgcg acagttcgag      780

tttgaagcga aagctagcaa cagtatcaac aggttttatt ttggatttgg aaacgagagt      840

ttctggtcat gaaaaaccca aaaaagaaat ccggaggatt ccggattgtc aatatgctaa      900

aacgcggagt agcccgtgtg agccgtacga tggtgagcaa gggcgaggag ctgttcaccg      960

gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt     1020

ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca     1080

ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt     1140

gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg     1200

aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg     1260

ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact     1320

tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg     1380

tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca     1440

acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg     1500

acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag     1560

accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca     1620

ctctcggcat ggacgagctg tacaagagtg ggggctccgg cgtgaaacag actttgaatt     1680

ttgaccttct caagttggcc ggagacgtcg agtccaaccc tgggcccgcg gccgccctga     1740

acacaaagaa tggatctatt tcccttatgt gcttggcctt agggggagtg ttgatcttct     1800

tatccacagc cgtctctgct gatgtggggt gctcggtgga cttctcaaag aaggagacga     1860

gatgcggtac cggggtgttc gtctataacg acgttgaagc ctggagggac aggtacaagt     1920

accatcctga ctccccccgt agattggcag cagcagtcaa gcaagcctgg gaagatggta     1980

tctgcgggat ctcctctgtt tcaagaatgg aaaacatcat gtggagatca gtagaagggg     2040

agctcaacgc aatcctggaa gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa     2100

aaaaccccat ggggagaggt ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg     2160

gctggaaggc ttgggggaaa tcgtatttcg tcagagcagc aaagacaaat aacagctttg     2220

tcgtggatgg tgacacactg aaggaatgcc cactcaaaca tagagcatgg aacagctttc     2280

ttgtggagga tcatgggttc ggggtatttc acactagtgt ctggctcaag gttagagaag     2340

attattcatt agagtgtgat ccagccgtta ttggaacagc tgttaaggga aaggaggctg     2400

tacacagtga tctaggctac tggattgaga gtgagaagaa tgacacatgg aggctgaaga     2460

gggcccatct gatcgagatg aaaacatgtg aatggccaaa gtcccacaca ttgtggacag     2520

atggaataga agagagtgat ctgatcatac ccaagtcttt agctgggcca ctcagccatc     2580

acaataccag agagggctac aggacccaaa tgaaagggcc atggcacagt gaagagcttg     2640

aaattcggtt tgaggaatgc ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa     2700

gaggaccatc tctgagatca accactgcaa gcggaagggt gatcgaggaa tggtgctgca     2760

gggagtgcac aatgccccca ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg     2820

agataaggcc caggaaagaa ccagaaagca acttagtaag gtcaatggtg actgcaggat     2880

caactgatca catggaccac ttctcccttg gagtgcttgt gatcctgctc atggtgcagg     2940

aagggctgaa gaagagaatg accacaaaga tcatcataag cacatcaatg gcagtgctgg     3000

tagctatgat cctgggagga ttttcaatga gtgacctggc taagcttgca attttgatgg     3060

gtgccacctt cgcggaaatg aacactggag gagatgtagc tcatctggcg ctgatagcgg     3120

cattcaaagt cagaccagcg ttgctggtat ctttcatctt cagagctaat tggacacccc     3180

gtgaaagcat gctgctggcc ttggcctcgt gtcttttgca aactgcgatc tccgccttgg     3240

aaggcgacct gatggttctc atcaatggtt ttgctttggc ctggttggca atacgagcga     3300

tggttgttcc acgcactgat aacatcacct tggcaatcct ggctgctctg acaccactgg     3360

cccggggcac actgcttgtg gcgtggagag caggccttgc tacttgcggg gggtttatgc     3420

tcctctctct gaagggaaaa ggcagtgtga agaagaactt accatttgtc atggccctgg     3480

gactaaccgc tgtgaggctg gtcgacccca tcaacgtggt gggactgctg ttgctcacaa     3540

ggagtgggaa gcggagctgg ccccctagcg aagtactcac agctgttggc ctgatatgcg     3600

cattggctgg agggttcgcc aaggcagata tagagatggc tgggcccatg gccgcggtcg     3660

gtctgctaat tgtcagttac gtggtctcag gaaagagtgt ggacatgtac attgaaagag     3720

caggtgacat cacatgggaa aaagatgcgg aagtcactgg aaacagtccc cggctcgatg     3780

tggcgctaga tgagagtggt gatttctccc tggtggagga tgacggtccc cccatgagag     3840

agatcatact caaggtggtc ctgatgacca tctgtggcat gaacccaata gccataccct     3900

ttgcagctgg agcgtggtac gtatacgtga agactggaaa aaggagtggt gctctatggg     3960

atgtgcctgc tcccaaggaa gtaaaaaagg gggagaccac agatggagtg tacagagtaa     4020

tgacgcgtag actgctaggt tcaacacaag ttggagtggg agttatgcaa gagggggtct     4080

ttcacactat gtggcacgtc acaaaaggat ccgcgctgag aagcggtgaa gggagacttg     4140

atccatactg gggagatgtc aagcaggatc tggtgtcata ctgtggtcca tggaagctag     4200

atgccgcctg ggatgggcac agcgaggtgc agctcttggc cgtgcccccc ggagagagag     4260

cgaggaacat ccagactctg cccggaatat ttaagacaaa ggatggggac attggagcgg     4320

ttgcgctgga ttacccagca ggaacttcag gatctccaat cctagacaag tgtgggagag     4380

tgataggact ttatggcaat ggggtcgtga tcaaaaacgg gagttatgtt agtgccatca     4440

cccaagggag gagggaggaa gagactcctg ttgagtgctt cgagccctcg atgctgaaga     4500

agaagcagct aactgtctta gacttgcatc ctggagctgg gaaaaccagg agagttcttc     4560

ctgaaatagt ccgtgaagcc ataaaaacaa gactccgtac tgtgatctta gctccaacca     4620

gggttgtcgc tgctgaaatg gaggaggccc ttagagggct tccagtgcgt tatatgacaa     4680

cagcagtcaa tgtcacccac tctggaacag aaatcgtcga cttaatgtgc catgccacct     4740

tcacttcacg tctactacag ccaatcagag tccccaacta taatctgtat attatggatg     4800

aggcccactt cacagatccc tcaagtatag cagcaagagg atacatttca acaagggttg     4860

agatgggcga ggcggctgcc atcttcatga ccgccacgcc accaggaacc cgtgacgcat     4920

ttccggactc caactcacca attatggaca ccgaagtgga agtcccagag agagcctgga     4980

gctcaggctt tgattgggtg acggatcatt ctggaaaaac agtttggttt gttccaagcg     5040

tgaggaacgg caatgagatc gcagcttgtc tgacaaaggc tggaaaacgg gtcatacagc     5100

tcagcagaaa gacttttgag acagagttcc agaaaacaaa acatcaagag tgggactttg     5160

tcgtgacaac tgacatttca gagatgggcg ccaactttaa agctgaccgt gtcatagatt     5220

ccaggagatg cctaaagccg gtcatacttg atggcgagag agtcattctg gctggaccca     5280

tgcctgtcac acatgccagc gctgcccaga ggagggggcg cataggcagg aatcccaaca     5340

aacctggaga tgagtatctg tatggaggtg ggtgcgcaga gactgacgaa gaccatgcac     5400

actggcttga agcaagaatg ctccttgaca atatttacct ccaagatggc ctcatagcct     5460

cgctctatcg acctgaggcc gacaaagtag cagccattga gggagagttc aagcttagga     5520

cggagcaaag gaagaccttt gtggaactca tgaaaagagg agatcttcct gtttggctgg     5580

cctatcaggt tgcatctgcc ggaataacct acacagatag aagatggtgc tttgatggca     5640

cgaccaacaa caccataatg gaagacagtg tgccggcaga ggtgtggacc agacacggag     5700

agaaaagagt gctcaaaccg aggtggatgg acgccagagt ttgttcagat catgcggccc     5760

tgaagtcatt caaggagttt gccgctggga aaagaggagc ggcttttgga gtgatggaag     5820

ccctgggaac actgccagga cacatgacag agagattcca ggaagccatt gacaacctcg     5880

ctgtgctcat gcgggcagag actggaagca ggccttacaa agccgcggcg gcccaattgc     5940

cggagaccct agagaccata atgcttttgg ggttgctggg aacagtctcg ctgggaatct     6000

tcttcgtctt gatgaggaac aagggcatag ggaagatggg ctttggaatg gtgactcttg     6060

gggccagcgc atggctcatg tggctctcgg aaattgagcc agccagaatt gcatgtgtcc     6120

tcattgttgt gttcctattg ctggtggtgc tcatacctga gccagaaaag caaagatctc     6180

cccaggacaa ccaaatggca atcatcatca tggtagcagt aggtcttctg ggcttgatta     6240

ccgccaatga actcggatgg ttggagagaa caaagagtga cctaagccat ctaatgggaa     6300

ggagagagga gggggcaacc ataggattct caatggacat tgacctgcgg ccagcctcag     6360

cttgggccat ctatgctgcc ttgacaactt tcattacccc agccgtccaa catgcagtga     6420

ccacctcata caacaactac tccttaatgg cgatggccac gcaagctgga gtgttgtttg     6480

gcatgggcaa agggatgcca ttctacgcat gggactttgg agtcccgctg ctaatgatag     6540

gttgctactc acaattaaca cccctgaccc taatagtggc catcattttg ctcgtggcgc     6600

actacatgta cttgatccca ggcctgcagg cagcagctgc gcgtgctgcc cagaagagaa     6660

cggcagctgg catcatgaag aaccctgttg tggatggaat agtggtgact gacattgaca     6720

caatgacaat tgacccccaa gtggagaaaa agatgggaca ggtgctactc atagcagtag     6780

ccgtctccag cgccatactg tcgcggaccg cctgggggtg gggggaggct ggggctctga     6840

tcacagccgc aacttccact ttgtgggaag gctctccgaa caagtactgg aactcctcta     6900

cagccacttc actgtgtaac atttttaggg gaagttactt ggctggagct tctctaatct     6960

acacagtaac aagaaacgct ggcttggtca agagacgtgg gggtggaaca ggagagaccc     7020

tgggagagaa atggaaggcc cgcttgaacc agatgtcggc cctggagttc tactcctaca     7080

aaaagtcagg catcaccgag gtgtgcagag aagaggcccg ccgcgccctc aaggacggtg     7140

tggcaacggg aggccatgct gtgtcccgag gaagtgcaaa gctgagatgg ttggtggagc     7200

ggggatacct gcagccctat ggaaaggtca ttgatcttgg atgtggcaga gggggctgga     7260

gttactacgt cgccaccatc cgcaaagttc aagaagtgaa aggatacaca aaaggaggcc     7320

ctggtcatga agaacccgtg ttggtgcaaa gctatgggtg gaacatagtc cgtcttaaga     7380

gtggggtgga cgtctttcat atggcggctg agccgtgtga cacgttgctg tgtgacatag     7440

gtgagtcatc atctagtcct gaagtggaag aagcacggac gctcagagtc ctctccatgg     7500

tgggggattg gcttgaaaaa agaccaggag ccttttgtat aaaagtgttg tgcccataca     7560

ccagcactat gatggaaacc ctggagcgac tgcagcgtag gtatggggga ggactggtca     7620

gagtgccact ctcccgcaac tctacacatg agatgtactg ggtctctgga gcgaaaagca     7680

acaccataaa aagtgtgtcc accacgagcc agctcctctt ggggcgcatg gacgggccta     7740

ggaggccagt gaaatatgag gaggatgtga atctcggctc tggcacgcgg gctgtggtaa     7800

gctgcgctga agctcccaac atgaagatca ttggtaaccg cattgaaagg atccgcagtg     7860

agcacgcgga aacgtggttc tttgacgaga accacccata taggacatgg gcttaccatg     7920

gaagctatga ggcccccaca caagggtcag cgtcctctct aataaacggg gttgtcaggc     7980

tcctgtcaaa accctgggat gtggtgactg gagtcacagg aatagccatg accgacacca     8040

caccgtatgg tcagcaaaga gttttcaagg aaaaagtgga cactagggtg ccagaccccc     8100

aagaaggcac tcgtcaggtt atgagcatgg tctcttcctg gttgtggaaa gagctaggca     8160

aacacaaacg gccacgagtc tgcaccaaag aagagttcat caacaaggtt cgtagcaatg     8220

cagcattagg ggcaatattt gaagaggaaa aagagtggaa gactgcagtg gaagctgtga     8280

acgatccaag gttctgggct ctagtggaca aggaaagaga gcaccacctg agaggagagt     8340

gccagagctg tgtgtacaac atgatgggaa aaagagaaaa gaaacaaggg gaatttggaa     8400

aggccaaggg cagccgcgcc atctggtata tgtggctagg ggctagattt ctagagtttg     8460

aagcccttgg attcttgaac gaggatcact ggatggggag agagaactca ggaggtggtg     8520

ttgaagggct gggattacaa agactcggat atgtcctaga agagatgagt cgtataccag     8580

gaggaaggat gtatgcagat gacactgctg gctgggacac ccgcattagc aggtttgatc     8640

tggagaatga agctctaatc accaaccaaa tggagaaagg gcacagggcc ttggcattgg     8700

ccataatcaa gtacacatac caaaacaaag tggtaaaggt ccttagacca gctgaaaaag     8760

ggaaaacagt tatggacatt atttcgagac aagaccaaag ggggagcgga caagttgtca     8820

cttacgctct taacacattt accaacctag tggtgcaact cattcggaat atggaggctg     8880

aggaagttct agagatgcaa gacttgtggc tgctgcggag gtcagagaaa gtgaccaact     8940

ggttgcagag caacggatgg gataggctca aacgaatggc agtcagtgga gatgattgcg     9000

ttgtgaagcc aattgatgat aggtttgcac atgccctcag gttcttgaat gatatgggaa     9060

aagttaggaa ggacacacaa gagtggaaac cctcaactgg atgggacaac tgggaagaag     9120

ttccgttttg ctcccaccac ttcaacaagc tccatctcaa ggacgggagg tccattgtgg     9180

ttccctgccg ccaccaagat gaactgattg gccgggcccg cgtctctcca ggggcgggat     9240

ggagcatccg ggagactgct tgcctagcaa aatcatatgc gcaaatgtgg cagctccttt     9300

atttccacag aagggacctc cgactgatgg ccaatgccat ttgttcatct gtgccagttg     9360

actgggttcc aactgggaga actacctggt caatccatgg aaagggagaa tggatgacca     9420

ctgaagacat gcttgtggtg tggaacagag tgtggattga ggagaacgac cacatggaag     9480

acaagacccc agttacgaaa tggacagaca ttccctattt gggaaaaagg gaagacttgt     9540

ggtgtggatc tctcataggg cacagaccgc gcaccacctg ggctgagaac attaaaaaca     9600

cagtcaacat ggtgcgcagg atcataggtg atgaagaaaa gtacatggac tacctatcca     9660

cccaagttcg ctacttgggt gaagaagggt ctacacctgg agtgctgtaa gcaccaatct     9720

taatgttgtc aggcctgcta gtcagccaca gcttggggaa agctgtgcag cctgtgaccc     9780

ccccaggaga agctgggaaa ccaagcctat agtcaggccg agaacgccat ggcacggaag     9840

aagccatgct gcctgtgagc ccctcagagg acactgagtc aaaaaacccc acgcgcttgg     9900

aggcgcagga tgggaaaaga aggtggcgac cttccccacc cttcaatctg gggcctgaac     9960

tggagatcag ctgtggatct ccagaagagg gactagtggt tagaggagac cccccggaaa    10020

acgcaaaaca gcatattgac gctgggaaag accagagact ccatgagttt ccaccacgct    10080

ggccgccagg cacagatcgc cgaatagcgg cggccggtgt ggggaaatcc atgggtctgg    10140

gtcggcatgg catctccacc tcctcgcggt ccgacctggg catccgaagg aggacgcacg    10200

tccactcgga tggctaaggg agttcgaatc tcatgtttga cagcttatta attaagactc    10260

gcgacagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga    10320

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc    10380

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag    10440

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtgtcatcga taagctttaa    10500

tgcggtagtt tatcacagtt aaattgctaa cgcagtcagg caccgtgtat gaaatctaac    10560

aatgcgctca tcgtcatcct cggcaccgtc accctggatg ctgtaggcat aggcttggtt    10620

atgccggtac tgccgggcct cttgcgggat atcgtccatt ccgacagcat cgccagtcac    10680

tatggcgtgc tgctagcgct atatgcgttg atgcaatttc tatgcgcacc cgttctcgga    10740

gcactgtccg accgctttgg ccgccgccca gtcctgctcg cttcgctact tggagccact    10800

atcgactacg cgatcatggc gaccacaccc gtcctgtgga tcctctacgc cggacgcatc    10860

gtggccggca tcaccggcgc cacaggtgcg gttgctggcg cctatatcgc cgacatcacc    10920

gatggggaag atcgggctcg ccacttcggg ctcatgagcg cttgtttcgg cgtgggtatg    10980

gtggcaggcc ccgtggccgg gggactgttg ggcgccatct ccttgcatgc accattcctt    11040

gcggcggcgg tgctcaacgg cctcaaccta ctactgggct gcttcctaat gcaggagtcg    11100

cataagggag agcgtcgacc gatgcccttg agagccttca acccagtcag ctccttccgg    11160

tgggcgcggg gcatgactat cgtcgccgca cttatgactg tcttctttat catgcaactc    11220

gtaggacagg tgccggcagc gctctgggtc attttcggcg aggaccgctt tcgctggagc    11280

gcgacgatga tcggcctgtc gcttgcggta ttcggaatct tgcacgccct cgctcaagcc    11340

ttcgtcactg gtcccgccac caaacgtttc ggcgagaagc aggccattat cgccggcatg    11400

gcggccgacg cgctgggcta cgtcttgctg gcgttcgcga cgcgaggctg gatggccttc    11460

cccattatga ttcttctcgc ttccggcggc atcgggatgc ccgcgttgca ggccatgctg    11520

tccaggcagg tagatgacga ccatcaggga cagcttcaag gatcgctcgc ggctcttacc    11580

agcctaactt cgatcactgg accgctgatc gtcacggcga tttatgccgc ctcggcgagc    11640

acatggaacg ggttggcatg gattgtaggc gccgccctat accttgtctg cctccccgcg    11700

ttgcgtcgcg gtgcatggag ccgggccacc tcgacctgaa tggaagccgg cggcacctcg    11760

ctaacggatt caccactcca agaattggag ccaatcaatt cttgcggaga actgtgaatg    11820

cgcaaaccaa cccttggcag aacatatcca tcgcgtccgc catctccagc agccgcacgc    11880

ggcgcatctc gggcagcgtt gggtcctggc cacgggtgcg catgatcgtg ctcctgtcgt    11940

tgaggacccg gctaggctgg cggggttgcc ttactggtta gcagaatgaa tcaccgatac    12000

gcgagcgaac gtgaagcgac tgctgctgca aaacgtctgc gacctgagca acaacatgaa    12060

tggtcttcgg tttccgtgtt tcgtaaagtc tggaaacgcg gaagtcagcg ccctgcacca    12120

ttatgttccg gatctgcatc gcaggatgct gctggctacc ctgtggaaca cctacatctg    12180

tattaacgaa gcgctggcat tgaccctgag tgatttttct ctggtcccgc cgcatccata    12240

ccgccagttg tttaccctca caacgttcca gtaaccgggc atgttcatca tcagtaaccc    12300

gtatcgtgag catcctctct cgtttcatcg gtatcattac ccccatgaac agaaatcccc    12360

cttacacgga ggcatcagtg accaaacagg aaaaaaccgc ccttaacatg gcccgcttta    12420

tcagaagcca gacattaacg cttctggaga aactcaacga gctggacgcg gatgaacagg    12480

cagacatctg tgaatcgctt cacgaccacg ctgatgagct ttaccgcagc tgcctcgcgc    12540

gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt    12600

gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg    12660

ggtgtcgggg cgcagccatg acccagtcac gtagcgatag cggagtgtat actggcttaa    12720

ctatgcggca tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca    12780

cagatgcgta aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc    12840

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg    12900

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa    12960

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga    13020

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag    13080

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct    13140

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg    13200

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc    13260

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt    13320

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta    13380

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac    13440

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc    13500

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat    13560

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc    13620

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt    13680

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta    13740

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct    13800

atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg    13860

cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga    13920

tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt    13980

atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt    14040

taatagtttg cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt    14100

tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat    14160

gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc    14220

cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc    14280

cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat    14340

gcggcgaccg agttgctctt gcccggcgtc aacacgggat aataccgcgc cacatagcag    14400

aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt    14460

accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc    14520

ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa    14580

gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg    14640

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa    14700

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac    14760

cattattatc atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtcttca    14820

a                                                                    14821


<210>  15
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eGFP

<400>  15
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  16
<211>  2382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Packaging vector

<400>  16
atgaaaaacc caaaaaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga       60

gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt      120

catgggccca tcaggatggt cttggcgatt ctagcctttt tgagattcac ggcaatcaag      180

ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaaca      240

ataaagaagt tcaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag      300

aagaagagac gaggcgcaga tactagtgtc ggaattgttg gcctcctgct gaccacagct      360

atggcagcgg aggtcactag acgtgggagt gcatactata tgtacttgga cagaaacgat      420

gctggggagg ccatatcttt tccaaccaca ttggggatga ataagtgtta tatacagatc      480

atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gctggatgag      540

ggggtggaac cagatgacgt cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac      600

ggaacctgcc atcacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctcccc      660

tcccattcca ccaggaagct gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac      720

acaaagcact tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca      780

gcggccgcca tcgcttggct tttgggaagc tcaacgagcc aaaaagtcat atacttggtc      840

atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac      900

tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt      960

gtcaccgtaa tggcacagga caaaccgact gtcgacatag agctggttac aacaacagtc     1020

agcaacatgg cggaggtaag atcctactgc tatgaggcat caatatcaga catggcttct     1080

gacagccgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat     1140

gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa     1200

gggagcctgg tgacatgcgc taagtttgca tgctccaaga aaatgaccgg gaagagcatc     1260

cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg     1320

atgatcgtta atgacacagg acatgaaact gatgagaata gagcgaaagt tgagataacg     1380

cccaattcac cgagagccga agccaccctg gggggttttg gaagcctagg acttgattgt     1440

gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac     1500

tggttggttc acaaggagtg gttccacgac attccattac cttggcacgc tggggcagac     1560

accggaactc cacactggaa caacaaagaa gcactggtag agttcaagga cgcacatgcc     1620

aaaaggcaaa ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct     1680

ggagctctgg aggctgagat ggatggtgca aagggaaggc tgtcctctgg ccacctgaaa     1740

tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtactgca     1800

gcgttcacat tcaccaagat cccggctgaa acactgcacg ggacagtcac agtggagtta     1860

cagtacgcag ggacagatgg accttgcaag gttccagctc agatggcggt ggacatgcaa     1920

actctgaccc cagttgggag gttgataacc gctaaccccg taatcactga aagcactgag     1980

aactctaaga tgatgctgga acttgatcca ccatttgggg actcttacat tgtcatagga     2040

gtcggggaga agaagatcac ccaccactgg cacaggagtg gcagcaccat tggaaaagca     2100

tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggac     2160

tttggatcag ttggaggcgc tctcaactca ttgggcaagg gcatccatca aatttttgga     2220

gcagctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg     2280

ttgctgatgt ggttgggtct gaacacaaag aatggatcta tttcccttat gtgcttggcc     2340

ttagggggag tgttgatctt cttatccaca gccgtctctg ct                        2382


<210>  17
<211>  794
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Packaging vector

<400>  17

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Thr 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Leu Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala 
785                 790                 


<210>  18
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2A

<400>  18
ggctccggcg tgaaacagac tttgaatttt gaccttctca agttggccgg agacgtcgag       60

tccaaccctg ggccc                                                        75


